Details of the Drug

General Information of Drug (ID: DMGCHW9)

Drug Name	Benzo(b)carbazol-11-one compound 2
Synonyms	PMID27646564-Compound-10-1
Drug Type	Small molecular drug
Structure	3D Structure is Not Available
Structure	3D MOL	2D MOL
Cross-matching ID	TTD ID D0O9JD

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proto-oncogene c-Ret (RET)	TT4DXQT	RET_HUMAN	Inhibitor	[1]
RET G691S mutant (RET G691S)	TTY0WT7	RET_HUMAN	Inhibitor	[1]
RET M918T mutant (RET M918T)	TT5XA6U	RET_HUMAN	Inhibitor	[1]
RET S891A mutant (RET S891A)	TT8BF4A	RET_HUMAN	Inhibitor	[1]
RET V804L mutant (RET V804L)	TT2RTDH	RET_HUMAN	Inhibitor	[1]
RET V804M mutant (RET V804M)	TTQV3NX	RET_HUMAN	Inhibitor	[1]
RET Y791F mutant (RET Y791F)	TTB0IO2	RET_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proto-oncogene c-Ret (RET)	DTT	RET	9.18E-01	-0.36	-0.48

Molecular Expression Atlas (MEA)

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References

1	RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99.