Details of the Drug

General Information of Drug (ID: DMGF8MZ)

Drug Name
FPL-62064
Synonyms N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Indication
Disease Entry ICD 11 Status REF
Inflammation 1A00-CA43.1 Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 265.31
Logarithm of the Partition Coefficient (xlogp) 3.7
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C16H15N3O
IUPAC Name
N-(4-methoxyphenyl)-1-phenylpyrazol-3-amine
Canonical SMILES
COC1=CC=C(C=C1)NC2=NN(C=C2)C3=CC=CC=C3
InChI
InChI=1S/C16H15N3O/c1-20-15-9-7-13(8-10-15)17-16-11-12-19(18-16)14-5-3-2-4-6-14/h2-12H,1H3,(H,17,18)
InChIKey
WKLGNFJHVJIZPK-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
128268
ChEBI ID
CHEMBL4070705
CAS Number
103141-09-9
TTD ID
D02YEY
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Drug Pharmacogenomic Perturbation (DPP)NEW Click to Jump to the Detailed DPP Information of This Drug
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Inflammation
ICD Disease Classification 1A00-CA43.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Arachidonate 5-lipoxygenase (5-LOX) DTT ALOX5 4.15E-01 -0.06 -0.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42.