Details of the Drug

General Information of Drug (ID: DMGH1LX)

Drug Name
BMS-509744
Synonyms
BMS-509744; 439575-02-7; BMS 509744; CHEMBL209148; N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide; GTPL9994; SCHEMBL14460651; KS-00001CVA; CHEBI:91404; MolPort-039-101-283; C32H41N5O4S2; BMS509744; BDBM50186460; 3499AH; compound 3 [PMID:16682193]; AKOS025142036; NCGC00229512-02; NCGC00229512-01
Indication
Disease Entry ICD 11 Status REF
Inflammation 1A00-CA43.1 Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 623.8
Logarithm of the Partition Coefficient (xlogp) 5.1
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C32H41N5O4S2
IUPAC Name
N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide
Canonical SMILES
CC1=CC(=C(C=C1SC2=CN=C(S2)NC(=O)C3=CC=C(C=C3)CNC(C)C(C)(C)C)C(=O)N4CCN(CC4)C(=O)C)OC
InChI
InChI=1S/C32H41N5O4S2/c1-20-16-26(41-7)25(30(40)37-14-12-36(13-15-37)22(3)38)17-27(20)42-28-19-34-31(43-28)35-29(39)24-10-8-23(9-11-24)18-33-21(2)32(4,5)6/h8-11,16-17,19,21,33H,12-15,18H2,1-7H3,(H,34,35,39)
InChIKey
ZHXNIYGJAOPMSO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11467730
ChEBI ID
CHEBI:91404
CAS Number
439575-02-7
TTD ID
D04PEI
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
T-cell-specific kinase (ITK) TT3C80U ITK_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 143 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.1773 5.1751 2.2936 9.0487
A4/Fukuda GDSC1 0.631 3.8754 0.2257 36.2594
MOLP-8 GDSC1 0.6906 9.0802 -1.9466 42.0453
Karpas-620 GDSC1 1.4641 3.518 1.245 25.0829
MOLM-13 GDSC1 1.6116 4.683 0.9774 26.0187
ALL-SIL GDSC1 1.753 3.5849 1.5391 21.4569
PL-21 GDSC1 1.7712 5.7647 0.6667 27.0914
ML-2 GDSC1 1.8759 3.7965 1.6021 20.3415
GA-10 GDSC1 2.0577 4.0228 1.7142 18.5765
OCI-AML-5 GDSC1 2.1586 4.3048 1.7075 18.1001
L-363 GDSC1 2.2416 5.4251 1.2914 20.6715
MOLT-16 GDSC1 2.2803 3.7936 2.0391 15.0869
SIG-M5 GDSC1 2.3077 3.2584 2.237 13.5654
697 GDSC1 2.3219 4.2852 1.8861 15.9758
RS4;11 GDSC1 2.3358 4.5416 1.7891 16.6187
ALL-PO GDSC1 2.4132 6.121 1.1264 21.0073
ATN-1 GDSC1 2.4562 5.9449 1.2522 19.9425
KMS-12-BM GDSC1 2.465 3.9879 2.1599 13.2541
CTV-1 GDSC1 2.466 4.0182 2.1486 13.3308
BE-13 GDSC1 2.4814 5.0368 1.709 16.5169
RPMI-8402 GDSC1 2.5312 4.831 1.8543 15.2012
Mono-Mac-6 GDSC1 2.5329 5.8477 1.3719 18.7485
NALM-6 GDSC1 2.5452 5.2915 1.6508 16.6563
BL-41 GDSC1 2.5483 8.1157 0.2736 25.6025
MV4-11 GDSC1 2.572 4.4504 2.0699 13.3916
SUP-M2 GDSC1 2.6299 3.4436 2.5381 9.6871
OCI-Ly19 GDSC1 2.6527 5.1138 1.8393 14.7596
Ku812 GDSC1 2.6664 4.3041 2.2313 11.7325
Karpas-231 GDSC1 2.7604 4.0105 2.4578 9.5865
SUP-T1 GDSC1 2.7846 7.2701 0.9046 20.8474
P32/ISH GDSC1 2.8333 3.8263 2.6128 8.0804
Karpas-45 GDSC1 2.8921 5.6941 1.781 14.1691
OPM-2 GDSC1 2.8956 5.5438 1.8582 13.5659
SR GDSC1 2.9033 3.987 2.6138 7.7315
OCI-AML-2 GDSC1 2.9177 4.5262 2.3749 9.4874
SU-DHL-6 GDSC1 3.017 4.4954 2.484 8.2141
NU-DUL-1 GDSC1 3.1224 7.724 0.9745 19.0126
MHH-PREB-1 GDSC1 3.1265 5.6231 2.026 11.3374
BC-1 GDSC1 3.156 6.2001 1.7642 13.2374
NKM-1 GDSC1 3.1684 6.0958 1.8269 12.7107
A3/Kawakami GDSC1 3.2176 4.2775 2.7754 5.1074
SU-DHL-8 GDSC1 3.2238 4.1313 2.8534 4.4716
Namalwa GDSC1 3.2445 6.4417 1.7194 13.2383
MOLT-4 GDSC1 3.2539 4.9412 2.4768 7.314
WIL2 NS GDSC1 3.2737 4.3797 2.7741 4.898
JSC-1 GDSC1 3.2752 5.1289 2.4014 7.8273
Loucy GDSC1 3.2837 5.3489 2.2988 8.6027
QIMR-WIL GDSC1 3.315 5.0948 2.4523 7.2784
DEL GDSC1 3.325 5.2792 2.3685 7.9008
BALL-1 GDSC1 3.3274 8.6363 0.6921 20.02
Karpas-422 GDSC1 3.3473 5.467 2.2933 8.4109
SU-DHL-16 GDSC1 3.3855 5.8565 2.1304 9.5501
ST486 GDSC1 3.4839 5.9661 2.156 9.0018
AMO1 GDSC1 3.4871 5.1939 2.544 5.9462
DG-75 GDSC1 3.5466 5.7747 2.3017 7.647
MY-M12 GDSC1 3.5609 9.3806 0.5128 20.2316
CCRF-CEM GDSC1 3.571 6.7504 1.8346 11.1824
SK-MM-2 GDSC1 3.5959 6.9896 1.7351 11.8495
SUP-HD1 GDSC1 3.605 7.1261 1.6744 12.2734
RL GDSC1 3.6151 7.9688 1.2619 15.2221
LAMA-84 GDSC1 3.6163 8.3756 1.0598 16.5988
DND-41 GDSC1 3.6228 6.6461 1.9278 10.2935
MC116 GDSC1 3.6476 4.7427 2.8882 2.7595
EM-2 GDSC1 3.6711 7.6988 1.4414 13.7543
Farage GDSC1 3.7009 5.7156 2.45 5.9899
DoHH2 GDSC1 3.7123 11.3798 -0.3629 24.2587
KOPN-8 GDSC1 3.7242 6.6397 2.0101 9.3251
HH [Human lymphoma] GDSC1 3.7604 8.3017 1.2116 15.0656
HEL GDSC1 3.7993 9.0259 0.8816 17.1265
KY821 GDSC1 3.8024 7.084 1.8498 10.2938
JJN-3 GDSC1 3.8082 5.7259 2.5236 5.098
SU-DHL-4 GDSC1 3.8141 5.4987 2.6383 4.2019
HL-60 GDSC1 3.8235 6.2338 2.2858 6.8861
MOLT-13 GDSC1 3.8317 7.0756 1.8764 9.9983
Ramos.2G6.4C10 GDSC1 3.8364 9.1436 0.8522 17.1869
HC-1 GDSC1 3.8389 6.4076 2.2117 7.4108
H9 GDSC1 3.8446 7.3811 1.7348 11.0207
RPMI-8866 GDSC1 3.8468 5.6663 2.5801 4.5553
IM-9 GDSC1 3.8657 8.639 1.1265 15.2887
GDM-1 GDSC1 3.8694 7.0192 1.9327 9.4518
KE-37 GDSC1 3.8969 8.389 1.2749 14.1682
Hs 445 GDSC1 3.899 6.4139 2.2527 6.9146
CTB-1 GDSC1 3.914 8.6054 1.1807 14.7594
BV-173 GDSC1 3.9211 10.0547 0.4652 19.2481
YT GDSC1 3.9246 6.9272 2.0194 8.6221
Reh GDSC1 3.933 11.8635 -0.4268 23.803
CA46 GDSC1 3.9371 9.0489 0.9783 16.0338
EoL-1 GDSC1 4.0149 12.7103 -0.7839 25.0843
MN-60 GDSC1 4.0212 6.0623 2.5091 4.6201
K-562 GDSC1 4.031 6.1182 2.489 4.7449
L-1236 GDSC1 4.0327 7.7936 1.6729 10.8831
SKM-1 GDSC1 4.0522 6.4519 2.343 5.7893
EJM GDSC1 4.0938 6.6882 2.2576 6.3199
Karpas-299 GDSC1 4.1225 7.5564 1.8554 9.2607
RPMI-6666 GDSC1 4.1316 7.3791 1.9486 8.5387
GR-ST GDSC1 4.1355 9.38 0.9665 15.4609
SCC-3 GDSC1 4.1719 5.7713 2.7417 2.5677
KG-1 GDSC1 4.1766 6.1472 2.5707 3.7765
U266B1 GDSC1 4.2004 8.0213 1.6843 10.2904
L-540 GDSC1 4.2117 9.4533 0.9879 15.0798
CESS GDSC1 4.2193 8.8857 1.2737 13.1445
U-698-M GDSC1 4.2321 7.1975 2.1074 7.0681
RPMI-8226 GDSC1 4.3037 11.4709 0.0589 20.2249
Jiyoye GDSC1 4.3112 6.6929 2.4007 4.6934
KMOE-2 GDSC1 4.3594 9.819 0.9179 15.069
OCI-M1 GDSC1 4.3652 6.1759 2.6719 2.6542
EB2 GDSC1 4.3825 8.3143 1.6716 9.8537
VL51 GDSC1 4.386 7.8492 1.8992 8.1887
DB GDSC1 4.3902 8.0825 1.7894 8.9788
PF-382 GDSC1 4.4392 9.6699 1.0501 13.972
KCL-22 GDSC1 4.4483 8.2554 1.7461 9.1317
LC4-1 GDSC1 4.4896 11.7421 0.0662 19.6051
L-428 GDSC1 4.5076 9.3915 1.2359 12.5351
Raji GDSC1 4.6014 8.7615 1.6077 9.7007
ROS-50 GDSC1 4.6351 8.8712 1.578 9.8177
THP-1 GDSC1 4.6477 9.424 1.3195 11.5688
P31/FUJ GDSC1 4.6701 7.2369 2.3706 4.1016
NK-92MI GDSC1 4.7089 6.8505 2.5659 2.714
NOMO-1 GDSC1 4.7238 9.9661 1.1099 12.7507
LP-1 GDSC1 4.7579 6.3059 2.8212 1.1286
Kasumi-1 GDSC1 4.7885 9.3197 1.4671 10.1751
ARH-77 GDSC1 4.8369 7.52 2.3404 3.9682
ME1 GDSC1 4.8753 9.0789 1.6402 8.7544
WSU-DLCL2 GDSC1 4.8858 5.9547 3.0086 0.2565
HAL-01 GDSC1 4.9528 9.1112 1.6756 8.3159
WSU-NHL GDSC1 4.96 9.8609 1.3238 10.6927
KM-H2 GDSC1 5.024 11.0515 0.7942 13.9086
JVM-2 GDSC1 5.0365 7.6262 2.4055 3.1691
TUR GDSC1 5.0587 7.3251 2.5467 2.2625
BC-3 GDSC1 5.1158 11.7983 0.4964 15.4168
MEG-01 GDSC1 5.1521 8.2748 2.1832 4.4034
EHEB GDSC1 5.2033 8.5165 2.1043 4.827
MLMA GDSC1 5.2612 11.2317 0.8706 12.8065
OCI-AML-3 GDSC1 5.2715 6.772 2.8624 0.5017
P30/OHK GDSC1 5.3056 13.4774 -0.1862 18.5216
Daudi GDSC1 5.352 14.2914 -0.5505 20.11
NB4 GDSC1 5.3689 7.524 2.6152 1.4813
JVM-3 GDSC1 5.373 7.2902 2.7091 1.0307
HT GDSC1 5.386 11.2582 0.9419 12.0481
Granta-519 GDSC1 5.4772 7.4514 2.6919 1.0126
SUP-B15 GDSC1 5.7019 14.3096 -0.3102 18.0719
HDLM-2 GDSC1 7.4828 17.7645 -0.7677 16.038
SU-DHL-1 GDSC1 7.8225 20.1764 -1.6864 18.9388
⏷ Show the Full List of 143 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 1.2558 5.4391 0.2867 32.0236
HCE-4 GDSC1 3.8819 7.1123 1.8962 9.6892
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.5859 7.5367 2.1803 5.6337
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GI-ME-N GDSC1 2.0705 7.2976 0.233 28.0024
NB69 GDSC1 2.3053 4.5821 1.7401 17.1283
LA-N-6 GDSC1 2.5482 5.2826 1.658 16.5895
KP-N-RT-BM-1 GDSC1 2.659 6.9342 0.9575 21.0398
NB(TU)1 GDSC1 3.1268 4.5896 2.5392 7.3245
TGW GDSC1 3.2011 4.9833 2.41 8.0421
SK-N-DZ GDSC1 3.422 4.6639 2.7563 4.4977
SK-N-BE(2)-M17 GDSC1 3.4559 5.0113 2.6102 5.5315
GOTO GDSC1 3.4673 8.5685 0.842 18.5601
SJNB-13 GDSC1 3.5257 5.3057 2.5188 6.0141
CHP-126 GDSC1 3.5481 6.9077 1.7377 11.9956
SJNB-14 GDSC1 3.6636 5.0292 2.7599 3.6988
Kelly GDSC1 3.7809 5.788 2.4735 5.5646
SJNB-17 GDSC1 3.8674 6.6782 2.0996 8.1849
IMR-5 GDSC1 3.946 9.1262 0.9468 16.2092
SJNB-7 GDSC1 3.9695 6.528 2.2477 6.746
NH-12 GDSC1 4.1804 6.5138 2.4002 5.0215
SJNB-5 GDSC1 4.2078 6.7123 2.3238 5.519
KP-N-YN GDSC1 4.2995 8.6892 1.4291 11.8216
SiMa GDSC1 4.7158 9.9159 1.1287 12.6504
SK-N-FI GDSC1 4.7225 7.1871 2.424 3.6297
MHH-NB-11 GDSC1 4.7987 7.2217 2.452 3.2957
SJNB-6 GDSC1 4.8893 9.6637 1.3705 10.5656
SJNB-10 GDSC1 5.3866 7.0198 2.8171 0.5862
NB1 GDSC1 6.2942 14.6663 -0.0776 15.4813
KP-N-YS GDSC1 6.4682 16.2895 -0.7368 18.1298
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NOS-1 [Human HNSCC] GDSC1 0.5919 3.0721 0.412 35.5862
EW-16 GDSC1 0.8408 3.9882 0.4157 33.9097
ES6 GDSC1 1.1457 4.5003 0.5573 31.2346
EW-1 GDSC1 1.6327 4.1107 1.2263 24.2565
SK-ES-1 GDSC1 2.0171 4.0911 1.6444 19.2854
ES4 GDSC1 2.0955 4.5338 1.545 19.589
SJSA-1 GDSC1 2.3389 4.1848 1.9462 15.4514
ES8 GDSC1 2.5257 9.5622 -0.4635 29.2186
ES1 GDSC1 2.8208 5.054 2.0282 12.5798
EW-3 GDSC1 2.9393 5.658 1.8417 13.5111
SK-PN-DW GDSC1 3.1023 5.4815 2.0752 11.05
EW-11 GDSC1 3.2673 7.1125 1.4034 15.4881
ES5 GDSC1 3.6868 7.4044 1.6005 12.5407
EW-18 GDSC1 3.7792 7.7537 1.4992 12.9693
EW-13 GDSC1 3.9866 7.4543 1.8058 10.0418
TC-71 GDSC1 4.4047 5.9937 2.7746 1.9051
ES7 GDSC1 4.46 9.9843 0.9109 14.8066
EW-12 GDSC1 4.7317 8.2189 1.9533 6.9075
EW-24 GDSC1 4.8319 6.2468 2.8781 0.7751
H-EMC-SS GDSC1 5.7007 7.8405 2.6382 1.0493
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1 2.5721 4.0648 2.2399 12.1283
Evsa-T GDSC1 3.5531 5.0372 2.6736 4.7105
CAL-148 GDSC1 4.2632 8.8379 1.3296 12.6243
MRK-nu-1 GDSC1 4.4201 8.3528 1.6794 9.6913
HCC2157 GDSC1 4.5322 7.1629 2.3208 4.7532
HCC1187 GDSC1 4.5772 7.3656 2.2546 5.1219
DU4475 GDSC1 4.9552 11.0635 0.7401 14.4276
BT-474 GDSC1 4.9653 6.6837 2.7656 1.1755
HCC1599 GDSC1 5.6441 12.7176 0.4176 14.4678
MFM-223 GDSC1 5.8429 7.4068 2.852 0.2664
COLO 824 GDSC1 6.3246 12.0583 1.1594 8.5869
HCC2218 GDSC1 6.6054 17.3902 -1.1723 19.6132
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KS-1 [Human Krukenberg tumour] GDSC1 0.4145 3.4 0.1337 38.2107
D-336MG GDSC1 2.3706 7.8261 0.2547 26.4919
SNB-75 GDSC1 2.6522 11.954 -1.5426 32.5728
NMC-G1 GDSC1 2.7218 9.2278 -0.1238 26.8768
GB-1 GDSC1 2.8659 4.4113 2.3797 9.6816
KALS-1 GDSC1 2.8735 4.9677 2.1197 11.6478
SF268 GDSC1 3.2541 6.5169 1.69 13.4237
8-MG-BA GDSC1 3.7431 6.0605 2.3114 6.9352
Onda 11 GDSC1 3.7658 8.626 1.0544 16.1127
KINGS-1 GDSC1 3.8487 9.7017 0.584 18.7976
Becker GDSC1 4.0055 5.9666 2.5444 4.3966
KNS-42 GDSC1 4.1337 11.4287 -0.0519 21.3405
AM-38 GDSC1 4.4801 6.1259 2.7578 1.8848
D-247MG GDSC1 4.4857 9.7032 1.0677 13.7175
ONS-76 GDSC1 4.5008 9.0792 1.3834 11.5488
D283 Med GDSC1 4.5567 10.8193 0.5717 16.5917
CAS-1 GDSC1 4.5986 8.0921 1.9263 7.4316
U-87MG ATCC GDSC1 4.7605 9.3971 1.4107 10.6365
SF126 GDSC1 4.8365 6.4304 2.8076 1.1078
D-263MG GDSC1 5.0623 11.8098 0.453 15.8129
GI-1 GDSC1 5.1547 16.3055 -1.6876 25.1294
KNS-81-FD GDSC1 5.4459 8.78 2.1241 4.2425
D-502MG GDSC1 5.5572 7.8841 2.5578 1.5597
Onda 10 GDSC1 6.4756 21.2826 -3.159 26.3307
SF539 GDSC1 7.2009 16.9334 -0.5581 15.7144
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.0594 4.5027 0.4644 32.2712
TGBC24TKB GDSC1 3.1504 5.986 1.8661 12.4804
TGBC1TKB GDSC1 3.6524 6.826 1.8615 10.7005
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 2.247 3.8434 1.9848 15.6495
KLE GDSC1 5.2585 10.3212 1.3028 10.0723
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OS-RC-2 GDSC1 2.6668 8.122 0.3769 24.5264
HA7-RCC GDSC1 2.7909 6.3164 1.3821 17.5506
LB1047-RCC GDSC1 2.9456 5.571 1.8904 13.1122
LB996-RCC GDSC1 3.2788 4.8677 2.535 6.762
RXF 393L GDSC1 3.5989 8.3123 1.0773 16.5433
TK-10 GDSC1 3.6992 5.6871 2.4627 5.8961
A-704 GDSC1 3.9616 6.3956 2.3067 6.3186
BB65-RCC GDSC1 4.5787 9.3329 1.3152 11.7932
LB2241-RCC GDSC1 5.1348 10.713 1.0337 12.1216
A-498 GDSC1 5.2973 6.7266 2.889 0.4013
RCC10RGB GDSC1 5.6096 20.3304 -3.3339 28.7346
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KM12 GDSC1 0.8062 2.3976 0.7646 32.1332
RKO GDSC1 1.2952 3.6589 1.0176 27.5547
NCI-H747 GDSC1 1.932 4.6762 1.3146 22.0525
LS411N GDSC1 1.9504 5.9971 0.7372 25.748
SNU-C2B GDSC1 2.1392 5.6963 1.0637 22.7256
LS1034 GDSC1 2.8379 5.6818 1.7375 14.7256
COLO 320HSR GDSC1 3.3474 4.7198 2.6671 5.4662
C2BBe1 GDSC1 3.7826 5.89 2.4247 5.9364
SNU-C1 GDSC1 3.9719 11.3367 -0.1333 22.2808
LS513 GDSC1 4.2607 6.5175 2.4508 4.4498
LS123 GDSC1 4.2881 8.0417 1.7374 9.6469
MDST8 GDSC1 4.5205 8.0517 1.8935 7.8706
NCI-H716 GDSC1 4.9192 11.0463 0.7231 14.6314
CL-11 GDSC1 4.9932 7.2951 2.5255 2.4906
CW-2 GDSC1 5.8792 7.8352 2.7133 0.6352
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 5.696 7.618 2.7202 0.7287
Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LC-2/ad GDSC1 1.4078 4.0432 1.0094 26.9538
NCI-H1975 GDSC1 2.0711 5.3669 1.1491 22.4855
IA-LM GDSC1 2.2105 5.2958 1.3207 20.6161
HOP-62 GDSC1 2.4005 7.4318 0.4758 25.141
LXF 289 GDSC1 2.4937 5.0685 1.7063 16.4807
NCI-H1355 GDSC1 2.6371 6.8805 0.9639 21.0929
Ms-1 GDSC1 2.8153 4.5856 2.2479 10.9174
NCI-H1648 GDSC1 3.0708 8.3045 0.6404 21.3295
NCI-H1876 GDSC1 3.318 4.9161 2.5442 6.5429
Lu-134-A GDSC1 3.3874 5.9507 2.0848 9.8991
CPC-N GDSC1 3.4271 5.5903 2.2977 8.0911
NCI-H847 GDSC1 3.4616 4.6572 2.7913 4.0872
NCI-H1436 GDSC1 3.5005 8.2786 1.0142 17.3191
LB647-SCLC GDSC1 3.6387 5.582 2.469 6.0367
COR-L95 GDSC1 3.6579 9.8687 0.3478 20.8299
NCI-H2171 GDSC1 3.7346 5.7469 2.4597 5.811
NCI-H1770 GDSC1 3.7596 9.755 0.4864 19.68
COLO 668 GDSC1 3.8235 6.6843 2.0637 8.5965
NCI-H1836 GDSC1 3.8309 5.5041 2.6474 4.086
NCI-H211 GDSC1 3.8391 7.9453 1.4506 13.1197
NCI-H1092 GDSC1 3.8804 6.1939 2.3469 6.2459
NCI-H1581 GDSC1 3.8838 5.7531 2.5638 4.5762
NCI-H526 GDSC1 3.8968 7.4967 1.7173 10.9833
NCI-H748 GDSC1 3.9202 9.8928 0.5452 18.784
NCI-H524 GDSC1 4.0121 7.6036 1.7512 10.3693
NCI-H187 GDSC1 4.0836 10.1568 0.5414 18.261
NCI-H23 GDSC1 4.124 6.4561 2.39 5.2432
NCI-H2135 GDSC1 4.1293 6.174 2.5277 4.2059
NCI-H510A GDSC1 4.1554 8.9236 1.2072 13.7977
IST-SL1 GDSC1 4.2046 7.1338 2.1191 7.0558
Lu-139 GDSC1 4.2271 7.9046 1.7606 9.6542
NCI-H64 GDSC1 4.2382 6.5537 2.4192 4.7363
DMS 114 GDSC1 4.3366 6.4846 2.5139 3.8175
NCI-H2141 GDSC1 4.3522 10.0141 0.8165 15.7322
NCI-H1694 GDSC1 4.3548 8.2667 1.6752 9.9067
NCI-H82 GDSC1 4.4198 9.8817 0.9318 14.7952
HCC33 GDSC1 4.5668 7.6504 2.1147 6.1517
IST-SL2 GDSC1 4.6372 9.7507 1.1534 12.7114
NCI-H2081 GDSC1 4.8336 7.245 2.4612 3.1703
NCI-H2196 GDSC1 4.8379 9.7035 1.3164 11.0668
NCI-H69 GDSC1 4.9396 10.0141 1.2365 11.3264
NCI-H720 GDSC1 4.9397 6.2987 2.904 0.5755
NCI-H209 GDSC1 4.953 6.9788 2.6389 1.8774
Lu-165 GDSC1 4.9548 7.2999 2.5032 2.6905
NCI-H1869 GDSC1 4.9783 6.6135 2.7994 0.9966
Calu-6 GDSC1 5.016 7.221 2.5689 2.1947
NCI-H1963 GDSC1 5.0717 11.0817 0.8128 13.6646
NCI-H1155 GDSC1 5.1695 6.6875 2.8527 0.6039
NCI-H322M GDSC1 5.3048 12.0717 0.4961 14.9067
EKVX GDSC1 5.3102 9.1104 1.8983 5.9847
NCI-H1304 GDSC1 5.5114 7.0514 2.8543 0.3955
COR-L88 GDSC1 5.5497 7.8761 2.5576 1.5692
DMS 79 GDSC1 5.5913 7.9223 2.5582 1.5212
NCI-H1838 GDSC1 5.6528 10.913 1.2771 9.3038
NCI-H1650 GDSC1 5.9069 8.4135 2.506 1.447
Lu-65 GDSC1 5.9627 14.6928 -0.3144 17.4326
SBC-1 GDSC1 6.0117 7.6974 2.8124 0.2963
NCI-H1666 GDSC1 6.0734 8.3609 2.5969 0.9229
NCI-H345 GDSC1 6.3201 17.3456 -1.3489 20.9632
SHP-77 GDSC1 6.4751 14.6229 0.0618 14.3635
NCI-H128 GDSC1 6.8177 17.1965 -0.9352 18.1712
NCI-H226 GDSC1 6.9496 16.5407 -0.5357 16.1552
NCI-H446 GDSC1 7.1545 24.3925 -4.1889 27.3977
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.6033 10.8997 0.5666 16.4815
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-8 GDSC1 2.0688 4.3158 1.6088 19.2693
TE-11 GDSC1 2.7292 4.7147 2.1032 12.4106
TE-15 GDSC1 3.002 4.4595 2.4873 8.253
TE-1 GDSC1 3.0543 8.0766 0.7399 20.7848
TE-10 GDSC1 3.1336 4.7613 2.4605 7.9129
TE-9 GDSC1 3.5071 5.4843 2.4151 6.8915
TE-6 GDSC1 4.1829 7.1884 2.0777 7.4264
TE-5 GDSC1 5.0468 10.2946 1.1747 11.4471
EC-GI-10 GDSC1 5.5147 7.2796 2.7725 0.661
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-4 GDSC1 3.1238 6.9266 1.3738 16.2544
Kuramochi GDSC1 3.9048 7.8528 1.547 12.2084
ES-2 GDSC1 4.359 5.7264 2.8656 1.4155
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 1.3894 2.9826 1.2991 25.164
MZ-PC-1 GDSC1 1.9304 4.8289 1.2471 22.5273
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 2.7137 3.8969 2.4584 9.8134
MPP 89 GDSC1 3.3536 8.5162 0.774 19.4133
MSTO-211H GDSC1 5.385 8.6337 2.1548 4.1556
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 2.2303 3.7437 2.0034 15.6068
LNCaP clone FGC GDSC1 4.806 7.9181 2.1404 5.412
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.8017 5.3091 2.7214 3.6037
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH-4 GDSC1 1.2822 4.7751 0.5932 30.2214
HT-144 GDSC1 1.898 4.7151 1.2627 22.5874
A101D GDSC1 2.4031 4.3517 1.9415 15.1658
MZ-MEL-2 GDSC1 2.4116 7.6668 0.3707 25.6798
IST-MEL1 GDSC1 2.6423 5.7145 1.5397 17.044
CP67-MEL GDSC1 2.8079 4.7809 2.1477 11.7185
MZ-MEL-7 GDSC1 3.0148 5.5772 1.9497 12.3733
UACC-257 GDSC1 3.4732 9.1647 0.5488 20.3397
MMAc-SF GDSC1 4.0481 9.0837 1.0466 15.2191
A-388 GDSC1 4.235 11.2233 0.1289 20.0761
LB373-MEL-D GDSC1 4.3763 8.8747 1.394 11.8382
LOX-IMVI GDSC1 4.3849 8.4992 1.5834 10.4789
GAK GDSC1 4.5562 8.5386 1.684 9.2818
DJM-1 GDSC1 4.5572 10.2404 0.8564 14.8587
LB2518-MEL GDSC1 4.6144 11.7783 0.1422 18.8244
CP66-MEL GDSC1 4.7467 8.5615 1.8011 7.951
SK-MEL-1 GDSC1 4.9169 8.049 2.1476 5.1208
COLO 800 GDSC1 5.5752 7.7217 2.6298 1.1987
COLO 829 GDSC1 5.7869 15.9805 -1.0628 21.1515
SK-MEL-2 GDSC1 6.4486 15.1617 -0.211 15.7728
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.832 3.2847 1.7117 19.8373
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFH-ino GDSC1 1.4067 3.7751 1.1011 26.3635
SW982 GDSC1 1.6721 3.2911 1.5356 21.9415
SW872 GDSC1 3.1528 4.7128 2.5016 7.5137
VA-ES-BJ GDSC1 3.4421 5.1086 2.5505 6.0496
SK-LMS-1 GDSC1 3.445 11.1255 -0.4547 25.6157
TE 441.T GDSC1 4.2122 6.44 2.4559 4.53
SK-UT-1 GDSC1 4.861 7.6307 2.3046 4.1627
EW-8 GDSC1 5.2424 11.8955 0.538 14.8342
SW684 GDSC1 6.6543 16.6139 -0.7664 17.8278
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1 GDSC1 2.9894 8.0068 0.7186 21.1773
GCIY GDSC1 3.3898 5.5681 2.2781 8.3777
HSC-39 GDSC1 3.5194 5.265 2.5341 5.9152
SNU-16 GDSC1 3.6085 9.5604 0.4617 20.3573
RF-48 GDSC1 4.2462 7.1543 2.1379 6.8029
SCH GDSC1 4.8124 6.6562 2.7036 1.7035
SNU-5 GDSC1 5.1364 7.4131 2.5489 2.1361
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 4.2765 6.2069 2.6052 3.3013
K5 GDSC1 5.991 12.3719 0.8094 11.3873
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 3.0084 6.455 1.5081 15.7363
LB771-HNC GDSC1 3.5002 9.6986 0.3041 21.6406
BB49-HNC GDSC1 3.5337 5.0768 2.639 5.0447
SCC-15 GDSC1 4.1808 9.2955 1.0426 14.8196
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 1.7336 2.8124 1.6988 20.5033
LB831-BLC GDSC1 2.1331 5.6778 1.0664 22.7379
SW954 GDSC1 2.7322 8.0237 0.4839 23.6423
SW962 GDSC1 2.7791 6.7154 1.1743 19.0654
KGN GDSC1 2.7926 6.0618 1.5091 16.6194
NCC-IT GDSC1 3.4484 4.8924 2.6635 5.1378
JAR GDSC1 3.5166 5.6225 2.3537 7.341
DSH1 GDSC1 4.297 6.1024 2.6653 2.8376
NEC8 GDSC1 4.8852 6.3725 2.8525 0.8409
OMC-1 [Human cervical carcinoma] GDSC1 5.6996 7.7274 2.6807 0.8761
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 Treatment of depersonalization with serotonin reuptake blockers. J Clin Psychopharmacol. 1990 Jun;10(3):200-3.