Details of the Drug

General Information of Drug (ID: DMGMF6V)

Drug Name
Capsaicin
Synonyms Capsaicin (transdermal patch formulation, neuropathic pain)
Indication
Disease Entry ICD 11 Status REF
Back pain ME84.Z Approved [1]
Neuropathic pain 8E43.0 Approved [2]
Pain MG30-MG3Z Approved [1]
Peripheral neuropathy 8C0Z Approved [1]
Polyneuropathy N.A. Approved [1]
Postherpetic neuralgia 1E91.5 Approved [1]
Type-1/2 diabetes 5A10-5A11 Approved [1]
Diabetic neuropathy 8C0Z Investigative [1]
Neuralgia N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Affected Organisms
Humans and other mammals
ATC Code
M02AB01: Capsaicin
M02AB: Capsaicin and similar agents
M02A: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M: MUSCULO-SKELETAL SYSTEM
N01BX04: Capsaicin
N01BX: Other local anesthetics
N01B: ANESTHETICS, LOCAL
N01: ANESTHETICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 305.4
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1 h [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [4]
Elimination
In vivo animal studies demonstrates that less than 10 % of an administered dose was found in faces after 48 h [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 24.9 +/- 5.0 minutes [3]
Metabolism
The drug is metabolized via the liver [3]
Water Solubility
The ability of drug to dissolve in water is measured as 0.06 mg/mL [4]
Chemical Identifiers
Formula
C18H27NO3
IUPAC Name
(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Canonical SMILES
CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey
YKPUWZUDDOIDPM-SOFGYWHQSA-N
Cross-matching ID
PubChem CID
1548943
ChEBI ID
CHEBI:3374
CAS Number
404-86-4
UNII
S07O44R1ZM
DrugBank ID
DB06774
TTD ID
D0U5CE
INTEDE ID
DR0268
ACDINA ID
D00911
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transient receptor potential cation channel V1 (TRPV1) TTMI6F5 TRPV1_HUMAN Agonist [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [6]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [6]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [6]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [6]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [6]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [6]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Post-Translational Modifications [7]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) OTU1KZPV AAPK2_HUMAN Post-Translational Modifications [7]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Gene/Protein Processing [8]
Albumin (ALB) OTVMM513 ALBU_HUMAN Gene/Protein Processing [9]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [10]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Gene/Protein Processing [11]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Gene/Protein Processing [11]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Gene/Protein Processing [11]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Gene/Protein Processing [12]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [13]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 8.4833 12.189 6.9916 20.6326
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 6.6968 9.4879 6.3523 35.9058
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 7.0903 8.2358 4.6922 0.1498
GaMG CTRP1 7.4238 12.236 3.1973 8.7164
LN-229 CTRP1 8.6554 11.6209 7.4279 16.3157
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP1 5.7214 8.2045 3.9981 7.1234
HEC-108 CTRP1 6.0378 7.7446 4.4174 2.7704
HEC-6 CTRP1 6.3193 11.2162 2.9569 13.5488
HEC-251 CTRP1 6.6347 10.3697 3.5737 7.9403
HEC-151 CTRP1 7.0429 8.5358 6.9763 29.2811
KLE CTRP1 7.1147 9.277 4.3176 1.6394
HEC-59 CTRP1 7.2941 10.4615 3.9143 3.9277
MFE-319 CTRP1 7.5216 13.7462 2.5561 12.7598
JHUEM-2 CTRP1 7.9783 14.1954 5.5425 31.7646
Ishikawa (Heraklio) 02 ER- CTRP1 6.0233 8.2014 4.2002 4.5355
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NU-DUL-1 CTRP1 2.0612 10.7407 0.9046 69.7322
Ku812 CTRP1 3.9157 5.8018 3.5518 19.1888
GDM-1 CTRP1 4.0366 10.8904 2.9876 60.9031
KE-97 CTRP1 5.1913 8.8817 3.2566 15.3626
BL-70 CTRP1 5.5612 7.2848 4.3316 4.7439
PL21 CTRP1 5.5658 8.9556 5.2745 49.9201
OCI-AML-3 CTRP1 5.6095 9.52 5.1592 49.4543
HT CTRP1 5.896 7.902 4.2597 4.3833
P3HR-1 CTRP1 6.1011 9.0869 3.8332 7.3528
MC116 CTRP1 6.2829 7.112 4.7901 0.2062
KMS-11 CTRP1 6.6044 8.1224 6.566 35.3286
THP-1 CTRP1 6.9801 11.3202 5.934 35.9023
U-937 CTRP1 7.0036 8.8156 6.8773 30.2682
LP-1 CTRP1 7.0534 8.4158 7.0064 28.9896
SKM-1 CTRP1 7.1781 11.2232 6.1797 33.3732
EJM CTRP1 7.3539 10.0751 6.8478 28.0947
SU-DHL-5 CTRP1 7.5814 8.4933 7.5584 21.2739
WSU-DLCL2 CTRP1 7.6116 9.4295 7.3646 22.557
NOMO-1 CTRP1 7.7368 8.6907 7.6974 19.1751
SU-DHL-4 CTRP1 7.9887 8.9686 7.9143 15.8422
MOLM-16 CTRP1 7.9936 10.7786 7.2049 21.5473
RPMI-8226 CTRP1 8.1827 12.2306 6.6944 24.3074
AMO1 CTRP1 8.4156 9.0342 8.3635 9.5792
OCI-Ly10 CTRP1 8.4778 12.2531 6.9549 20.9353
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB CTRP1 6.6517 10.7755 5.8235 38.7259
VMRC-RCW CTRP1 6.8952 10.2357 3.7933 5.6138
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320 CTRP1 6.945 12.7934 5.2311 38.7506
CW-2 CTRP1 7.2329 8.8725 7.1137 26.9604
SNU-C5 CTRP1 7.3141 8.9724 7.1776 25.9348
LS180 CTRP1 7.3171 8.0234 7.3143 24.903
KM12 CTRP1 7.6063 8.6245 7.5676 21.0334
SNU-C2A CTRP1 7.6158 10.2404 4.1627 1.8913
SNU-61 CTRP1 7.6355 8.827 7.5621 20.876
SNU-175 CTRP1 7.7992 8.6378 7.772 18.1935
SNU-C4 CTRP1 7.8755 8.9604 7.7929 17.5204
SNU-81 CTRP1 7.9266 9.014 7.8351 16.8592
SW403 CTRP1 7.9439 9.5089 4.559 0.1756
HT115 CTRP1 7.9758 9.1814 7.8413 16.4919
COLO 678 CTRP1 7.9869 9.7793 7.636 18.0797
HCT 116 CTRP1 8.0254 9.2961 7.8584 16.0427
SW948 CTRP1 8.0272 9.4243 7.8156 16.3746
RKO CTRP1 8.0849 8.9936 8.0131 14.4492
HT-55 CTRP1 8.2156 9.0079 8.152 12.5209
SNU-1040 CTRP1 8.2505 9.3994 8.0648 12.9916
RCM-1 [Human ESC] CTRP1 8.262 9.3437 8.0977 12.6552
NCI-H508 CTRP1 8.2906 9.2336 8.167 11.9216
SW620 CTRP1 8.3282 9.3008 8.1844 11.5489
HT-29 CTRP1 8.4136 8.855 8.3981 9.331
LoVo CTRP1 8.4172 9.8497 8.0534 12.1232
HCT 8 CTRP1 8.4756 9.0963 8.4117 8.8152
LS123 CTRP1 8.5835 10.6665 7.8312 13.1904
MDST8 CTRP1 8.6732 10.2996 8.0937 10.438
CL-40 CTRP1 8.6899 10.5035 8.01 11.0972
SW480 CTRP1 8.6943 11.128 7.7068 13.7453
CL-34 CTRP1 8.7204 9.9693 8.298 8.4003
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.017 9.7478 3.457 10.6996
SNU-398 CTRP1 7.4578 8.2517 7.4493 22.9333
SNU-449 CTRP1 7.5898 9.6811 4.3664 0.9195
Hep-G2 CTRP1 10.1289 12.8249 7.9755 6.0987
Cancer Drug Sensitivity Data Curated from 84 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H82 CTRP1 0.8991 3.4912 0.8317 58.4577
HCC33 CTRP1 4.5243 9.8942 2.1824 25.8321
NCI-H1963 CTRP1 5.1754 9.3672 4.7327 53.9636
NCI-H1568 CTRP1 5.3444 11.964 1.8413 24.1671
SCLC-21H CTRP1 5.485 8.587 5.2766 50.8919
NCI-H1930 CTRP1 5.5724 7.5776 4.1976 5.8743
NCI-H1694 CTRP1 5.633 8.9546 5.3481 49.1316
NCI-H2126 CTRP1 5.651 8.3806 3.8619 8.5312
NCI-H810 CTRP1 5.8029 9.0252 3.6564 9.767
COR-L279 CTRP1 5.8721 8.5532 3.9342 7.1951
SHP-77 CTRP1 5.8795 8.4121 4.007 6.5547
NCI-H2029 CTRP1 6.1034 8.9064 3.9204 6.6241
KNS-62 CTRP1 6.1075 8.9047 3.9239 6.5839
COLO 668 CTRP1 6.1502 9.7472 3.55 9.5246
NCI-H1048 CTRP1 6.184 9.9501 3.4756 10.018
Calu-6 CTRP1 6.2492 9.8213 3.5817 8.9679
Calu-3 CTRP1 6.3514 9.1044 3.9849 5.4325
BEN CTRP1 6.3528 7.5896 4.6411 0.7694
NCI-H1975 CTRP1 6.3865 8.6886 4.1946 3.7082
NCI-H2009 CTRP1 6.4237 11.5662 2.8606 13.9025
LXF 289 CTRP1 6.4307 10.2026 3.5208 8.921
LCLC-97TM1 CTRP1 6.4624 11.838 2.7558 14.5103
NCI-H1876 CTRP1 6.4726 11.5337 5.3181 41.698
NCI-H1355 CTRP1 6.4846 10.9611 3.1948 11.2745
NCI-H727 CTRP1 6.5048 9.5772 3.8608 6.0294
COR-L88 CTRP1 6.5448 8.7277 4.2647 2.867
NCI-H1573 CTRP1 6.5742 9.4649 3.9539 5.1328
DMS 273 CTRP1 6.5993 10.5752 3.4546 8.9589
NCI-H1437 CTRP1 6.6198 9.8724 3.7951 6.2554
VMRC-LCD CTRP1 6.6512 9.1158 4.1533 3.4628
NCI-H2286 CTRP1 6.6562 8.2417 4.5203 1.0691
HCC4006 CTRP1 6.6883 9.6187 6.2998 36.2591
NCI-H661 CTRP1 6.7035 10.2666 3.6646 7.0571
LC-1/sq-SF CTRP1 6.7154 12.3986 2.661 14.3641
Lu-65 CTRP1 6.7644 9.4269 4.0791 3.7765
EPLC-272H CTRP1 6.7961 9.2743 4.1623 3.1217
NCI-H2342 CTRP1 6.8176 8.3304 6.7664 32.3809
LCLC-103H CTRP1 6.8391 8.3232 4.5669 0.6678
NCI-H1944 CTRP1 6.9112 10.1208 3.8541 5.1249
ChaGo-K-1 CTRP1 6.9155 9.7914 4.0021 4.0319
RERF-LC-KJ CTRP1 6.9557 9.5067 4.146 2.9495
NCI-H23 CTRP1 6.9558 10.0241 3.9221 4.5296
NCI-H1836 CTRP1 6.9884 9.9856 6.4926 32.9221
NCI-H1915 CTRP1 7.0545 9.1674 4.3338 1.6232
HARA [Human squamous cell lung carcinoma] CTRP1 7.0552 9.387 4.2453 2.1476
NCI-H650 CTRP1 7.0783 10.5034 3.7784 5.3199
NCI-H1435 CTRP1 7.1117 11.7521 3.2291 9.2683
NCI-H2405 CTRP1 7.1416 9.8334 4.1026 2.9258
A-549 CTRP1 7.1769 9.1638 4.3896 1.1849
NCI-H1792 CTRP1 7.2469 12.8465 2.8026 11.886
HCC2935 CTRP1 7.2885 9.5205 6.9836 27.5474
CAL-12T CTRP1 7.3184 8.5656 7.2679 25.232
COLO 699 CTRP1 7.3475 8.8878 7.235 25.2792
COR-L51 CTRP1 7.406 8.3866 7.3845 23.7683
NCI-H2081 CTRP1 7.4199 8.9873 7.2893 24.3841
HCC44 CTRP1 7.4205 9.2904 4.4429 0.735
HCC2108 CTRP1 7.4522 8.5894 7.4077 23.2771
NCI-H1105 CTRP1 7.4537 8.2127 7.4471 22.979
NCI-H841 CTRP1 7.4567 9.1761 7.277 24.2337
HCC1359 CTRP1 7.4678 9.3607 7.2316 24.5088
HCC1833 CTRP1 7.4803 9.2255 7.2879 23.996
NCI-H2141 CTRP1 7.5781 8.1267 7.5768 21.1632
NCI-H1299 CTRP1 7.6695 11.7933 3.5379 5.7978
NCI-H3255 CTRP1 7.6801 9.7238 7.3318 22.3852
NCI-H1666 CTRP1 7.7062 10.6575 4.0374 2.4884
DV-90 CTRP1 7.8138 9.63 4.4713 0.414
NCI-H1755 CTRP1 7.9307 9.0221 7.8375 16.8142
NCI-H1781 CTRP1 7.9562 9.1127 7.8404 16.6253
HCC827 CTRP1 8.0455 9.5666 7.7822 16.5338
NCI-H2030 CTRP1 8.0478 9.1467 7.9302 15.3332
NCI-H596 CTRP1 8.0885 9.0456 8.0035 14.4996
NCI-H2122 CTRP1 8.0994 9.2791 7.9444 14.8939
HCC15 CTRP1 8.1703 9.4645 7.9545 14.3754
Sq-1 CTRP1 8.3105 9.3065 8.1633 11.8277
NCI-H2023 CTRP1 8.3268 10.003 7.8929 13.9894
NCI-H441 CTRP1 8.3391 9.3795 8.1674 11.6199
T3M-10 CTRP1 8.4624 9.4346 8.2773 9.9807
NCI-H2073 CTRP1 8.4814 12.7642 6.7053 22.7176
COR-L23 CTRP1 8.9004 10.792 8.057 9.7039
NCI-H2172 CTRP1 9.0464 12.0207 7.5676 13.383
SK-LU-1 CTRP1 9.5929 13.2697 7.3803 12.7953
NCI-H2110 CTRP1 9.7023 14.9476 6.6321 17.9911
NCI-H460 CTRP1 10.3009 12.3902 8.279 3.2534
HCC1195 CTRP1 10.4132 13.914 7.6459 7.98
⏷ Show the Full List of 84 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 CTRP1 5.062 7.9363 3.6228 12.8423
KYSE-450 CTRP1 6.3356 7.8062 4.547 1.3232
KYSE-410 CTRP1 7.8516 9.3927 4.5662 0.1851
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-4 CTRP1 6.1436 8.4369 6.023 42.239
OVCAR-8 CTRP1 6.3261 8.4274 6.2222 39.6454
RMG-I CTRP1 6.4368 10.3882 5.7496 40.675
SK-OV-3 CTRP1 6.7142 8.4394 4.4684 1.2854
JHOS-4 CTRP1 6.7217 13.796 1.9867 18.5009
COV434 CTRP1 6.7875 8.772 6.6521 33.3832
EFO-21 CTRP1 6.8728 9.0586 4.2921 2.125
OVKATE CTRP1 6.8878 8.9064 6.7294 32.1275
A2780 CTRP1 6.9538 9.4333 6.6494 32.1837
OVMANA CTRP1 7.0588 8.2755 4.6677 0.2107
COV318 CTRP1 7.143 12.5092 2.8945 11.5442
OVK18 CTRP1 7.2685 9.5787 6.9418 27.9853
HEY A8 CTRP1 7.278 9.3086 4.3774 1.1444
RMUG-S CTRP1 7.3947 12.2412 5.9324 33.2323
IGROV-1 CTRP1 7.6948 9.7305 7.345 22.1897
COV644 CTRP1 7.8504 8.9407 7.7703 17.8591
OV-90 CTRP1 8.0561 9.458 7.8344 16.0453
TYK-nu CTRP1 8.185 11.8103 6.901 22.8286
Caov-3 CTRP1 8.2039 9.1947 8.0854 13.116
SNU-840 CTRP1 8.4535 13.7195 6.2066 26.0319
OV7 CTRP1 9.1686 10.7842 8.2858 6.5261
COV362 CTRP1 9.3095 11.4978 8.0415 8.1741
OAW42 CTRP1 10.1756 11.7276 8.5001 1.888
JHOM-1 CTRP1 10.353 15.7352 6.7281 15.0543
EFO-27 CTRP1 10.5552 15.1382 7.1577 11.3403
JHOC-5 CTRP1 10.7585 14.5513 7.5668 7.6685
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 03.27 CTRP1 6.3243 9.5017 3.7827 7.1298
HuP-T4 CTRP1 6.5183 9.0916 4.0897 4.2172
QGP-1 CTRP1 6.5435 9.4748 3.9312 5.3824
PaTu 8902 CTRP1 6.6181 10.9274 3.3002 10.0858
KP-3 CTRP1 6.7405 9.0078 4.2471 2.6351
SUIT-2 CTRP1 7.0146 8.2871 4.6476 0.2778
Capan-2 CTRP1 7.0511 9.886 4.0337 3.5493
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 6.6088 10.2169 3.6288 7.5812
NCI-H28 CTRP1 7.5033 9.2384 4.4938 0.4992
NCI-H2052 CTRP1 7.5251 9.4997 4.4075 0.7997
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 7.8833 15.4924 1.9665 15.3032
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 852.T CTRP1 5.9673 11.8848 2.3703 18.734
G-361 CTRP1 6.7796 11.5675 3.1027 11.0879
Hs 944.T CTRP1 7.3913 9.5133 4.3472 1.1799
A-375 CTRP1 8.0826 9.2092 7.9489 14.9645
SK-MEL-5 CTRP1 8.1968 8.8098 8.1725 12.4926
SK-MEL-1 CTRP1 8.2353 8.9942 8.1769 12.2003
SK-MEL-28 CTRP1 8.9169 9.3496 8.7832 3.1425
Hs 936.T CTRP1 9.0307 17.9702 1.5367 14.789
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN CTRP1 4.2717 5.8002 4.2702 67.9948
G-401 CTRP1 6.5587 13.0357 2.2408 17.5317
HT-1080 CTRP1 8.7299 11.2286 7.689 13.7344
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 CTRP1 6.2145 10.2605 3.3468 10.9412
Fu97 CTRP1 6.3284 9.5995 3.7394 7.468
SH-10-TC CTRP1 6.5931 8.1977 4.5093 1.2042
MKN7 CTRP1 7.1011 10.8197 3.6499 6.2121
MKN74 CTRP1 7.1077 10.2728 3.8964 4.407
AGS CTRP1 7.3524 8.2495 7.3401 24.4673
SNG-M CTRP1 6.8105 8.6704 4.4203 1.4378
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.1917 8.7137 4.0671 5.1805
SCC-9 CTRP1 8.1205 9.0606 8.0343 14.0521
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 CTRP1 4.7121 8.2766 3.1526 18.292
HT-1376 CTRP1 6.1404 9.6249 3.6022 9.1314
UM-UC-3 CTRP1 6.3994 9.099 4.0165 5.0629
5637 CTRP1 6.8592 9.6598 4.029 3.9501
KMBC-2 CTRP1 7.0092 10.1062 3.9155 4.4679

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Diethylene glycol monoethyl ether E00169 8146 Solubilizing agent; Solvent
Butylhydroxyanisole E00308 24667 Antimicrobial preservative; Antioxidant
Edetate disodium E00186 8759 Complexing agent
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Sodium hydroxide E00234 14798 Alkalizing agent
Water E00035 962 Solvent
Silicone adhesive E00683 17317 Binding agent
Dimethicone 350 E00706 Not Available Antifoaming agent; Emollient; Water-repelling agent
Ethyl cellulose E00699 Not Available Coating agent; Microencapsulating agent; Binding agent; Diluent; Viscosity-controlling agent
⏷ Show the Full List of 9 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Capsaicin 8% Patch 8% Patch Topical
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Capsaicin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2486).
3 Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev. 2012 Oct;64(4):939-71. doi: 10.1124/pr.112.006163.
4 BDDCS applied to over 900 drugs
5 Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol. 2007;(179):155-71.
6 Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.
7 Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
8 Activation and modulation of recombinantly expressed serotonin receptor type 3A by terpenes and pungent substances. Biochem Biophys Res Commun. 2015 Nov 27;467(4):1090-6. doi: 10.1016/j.bbrc.2015.09.074. Epub 2015 Oct 9.
9 A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics. 2008 Nov;8(22):4748-67. doi: 10.1002/pmic.200800094.
10 Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells. FEBS Lett. 2009 Jan 5;583(1):141-7. doi: 10.1016/j.febslet.2008.11.038. Epub 2008 Dec 6.
11 Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
12 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
13 TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new "hot" cancer treatment. Biochim Biophys Acta. 2007 Apr;1773(4):565-76. doi: 10.1016/j.bbamcr.2007.01.001. Epub 2007 Jan 10.