Details of the Drug

General Information of Drug (ID: DMGP42V)

Drug Name

MK-7145

Synonyms

MK-7145; UNII-M371870BYL; M371870BYL; 1255204-84-2; SCHEMBL2894681; CHEMBL3696475; OCKGFTQIICXDQW-ZEQRLZLVSA-N; BDBM155921; AKOS032946121; DB11968; HY-18277; 5,5'-((1R,1'R)-Piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl))bis(4-methylisobenzofuran-1(3H)-one); 1(3H)-Isobenzofuranone, 5,5'-(1,4-piperazinediylbis((1R)-1-hydroxy-2,1-ethanediyl))bis(4-methyl-; US9018211, 2A; CS-0007374

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Phase 1	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C26H30N2O6
Canonical SMILES: CC1=C(C=CC2=C1COC2=O)C(CN3CCN(CC3)CC(C4=C(C5=C(C=C4)C(=O)OC5)C)O)O
InChI: 1S/C26H30N2O6/c1-15-17(3-5-19-21(15)13-33-25(19)31)23(29)11-27-7-9-28(10-8-27)12-24(30)18-4-6-20-22(16(18)2)14-34-26(20)32/h3-6,23-24,29-30H,7-14H2,1-2H3/t23-,24-/m0/s1
InChIKey: OCKGFTQIICXDQW-ZEQRLZLVSA-N

Cross-matching ID

PubChem CID: 59568713
CAS Number: 1255204-84-2
UNII: M371870BYL
DrugBank ID: DB11968
TTD ID: D0L9QM

References

1	ClinicalTrials.gov (NCT01370655) A Study of MK-7145 Compared to Placebo and Hydrochlorothiazide for Lowering Blood Pressure in Male Participants With Hypertension (MK-7145-009 AM1). U.S. National Institutes of Health.