Details of the Drug

General Information of Drug (ID: DMH1KMT)

Drug Name
Polidocanol
Synonyms Asclera (TN)
Indication
Disease Entry ICD 11 Status REF
Reticular veins EF20 Approved [1]
Spider veins EF20 Approved [1]
Varicose veins BD74-BD75 Approved [2]
Affected Organisms
Humans and other mammals
ATC Code
C05BB02: Polidocanol
C05BB: Sclerosing agents for local injection
C05B: ANTIVARICOSE THERAPY
C05: VASOPROTECTIVES
C: CARDIOVASCULAR SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 582.8
Logarithm of the Partition Coefficient (xlogp) 3.9
Rotatable Bond Count (rotbonds) 37
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 10
ADMET Property
Clearance
The sytemic clearance of drug is 0.2-0.4 L/min []
Half-life
The concentration or amount of drug in body reduced by one-half in 1.5 hours [3]
Vd
The volume of distribution (Vd) of drug is 35-82 L []
Chemical Identifiers
Formula
C30H62O10
IUPAC Name
2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES
CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI
InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3
InChIKey
ONJQDTZCDSESIW-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
656641
ChEBI ID
CHEMBL46859
CAS Number
3055-99-0
UNII
0AWH8BFG9A
DrugBank ID
DB06811
TTD ID
D05ZPL
ACDINA ID
D01350
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endothelium of blood vessels (Endothelium) TTT6K3S NOUNIPROTAC Modulator [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Hydrochloric acid E00015 313 Acidulant
Potassium phosphate monobasic E00429 516951 Buffering agent
Ethanol E00023 702 Antimicrobial preservative; Penetration agent; Solvent
Sodium hydroxide E00234 14798 Alkalizing agent
Sodium phosphate dibasic dihydrate E00498 6451167 Buffering agent; Complexing agent
Water E00035 962 Solvent
⏷ Show the Full List of 6 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Polidocanol 180mg/18ml solution 180mg/18ml Solution Intravenous
Polidocanol 77.5mg/7.75ml solution 77.5mg/7.75ml Solution Intravenous
Polidocanol 10mg/2ml solution 10mg/2ml Solution Intravenous
Polidocanol 20mg/2ml solution 20mg/2ml Solution Intravenous
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
2 Polidocanol FDA Label
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015