General Information of Drug (ID: DMH3RPO)

Drug Name
PT-630
Synonyms Non insulin dependent diabetes therapy, DARA BioSciences; Non insulin dependent diabetes therapy, Point Therapeutics
Indication
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Terminated [1]
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski):
0
Molecular Weight 244.06
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 5
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 6
Chemical Identifiers
Formula
C9H17BN2O5
IUPAC Name
(4S)-4-amino-5-[(2R)-2-boronopyrrolidin-1-yl]-5-oxopentanoic acid
Canonical SMILES
B([C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)N)(O)O
InChI
InChI=1S/C9H17BN2O5/c11-6(3-4-8(13)14)9(15)12-5-1-2-7(12)10(16)17/h6-7,16-17H,1-5,11H2,(H,13,14)/t6-,7-/m0/s1
InChIKey
DMTPQYQQHYOTQM-BQBZGAKWSA-N
Cross-matching ID
PubChem CID
11673176
TTD ID
D0F3TI

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dipeptidyl peptidase 4 (DPP-4) TTDIGC1 DPP4_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Type-2 diabetes
ICD Disease Classification 5A11
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dipeptidyl peptidase 4 (DPP-4) DTT DPP4 9.54E-01 -0.27 -1.85
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 7.1983 9.1876 4.3897 1.1632
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 7.1302 8.4953 4.6173 0.3109
LN-229 CTRP1 7.2034 12.0785 3.1346 9.7082
GaMG CTRP1 7.4335 8.6605 4.6678 0.1127
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-251 CTRP1 6.0654 7.6982 4.4536 2.4367
HEC-265 CTRP1 6.5695 7.6023 4.7237 0.2646
HEC-6 CTRP1 6.7106 8.0867 4.6028 0.6183
MFE-319 CTRP1 6.9047 8.6258 4.4797 1.0127
HEC-108 CTRP1 6.9386 8.099 4.6854 0.2116
JHUEM-2 CTRP1 7.0933 10.3593 3.8506 4.7651
HEC-59 CTRP1 7.1599 8.5425 4.6117 0.3134
HEC-151 CTRP1 7.2079 8.6252 4.6004 0.2831
KLE CTRP1 7.7481 9.6031 4.4564 0.4888
Ishikawa (Heraklio) 02 ER- CTRP1 6.517 7.4718 4.7501 0.2129
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NU-DUL-1 CTRP1 4.1054 13.0886 0.2242 35.7007
Ku812 CTRP1 5.4422 7.7012 4.042 7.6842
U-937 CTRP1 6.1199 9.5979 3.6012 9.2035
BL-70 CTRP1 6.4009 7.3808 4.7389 0.3068
OCI-AML-3 CTRP1 6.4934 13.0797 2.1721 18.1556
MC116 CTRP1 6.5329 7.3308 4.8041 0.0888
WSU-DLCL2 CTRP1 6.6705 8.137 4.567 0.8166
AMO1 CTRP1 6.7808 7.9696 4.6727 0.2749
PL21 CTRP1 6.8586 8.4614 4.523 0.8483
NOMO-1 CTRP1 6.8718 9.0361 4.3009 2.0713
EJM CTRP1 6.9072 8.3291 4.592 0.5168
SU-DHL-5 CTRP1 6.9285 7.8594 4.7626 0.0729
THP-1 CTRP1 6.9327 9.1401 4.2876 2.0641
SKM-1 CTRP1 6.9774 8.0207 4.7256 0.1183
HT CTRP1 6.9885 8.0674 4.7137 0.1365
SU-DHL-4 CTRP1 7.026 8.2072 4.6794 0.1953
P3HR-1 CTRP1 7.2347 8.5719 4.6286 0.2402
KE-97 CTRP1 7.2679 8.8023 4.5602 0.4133
LP-1 CTRP1 7.3143 8.6679 4.624 0.1954
MOLM-16 CTRP1 7.4272 9.1267 4.5049 0.5052
RPMI-8226 CTRP1 7.4392 8.8509 4.6057 0.223
GDM-1 CTRP1 7.5106 14.0597 2.401 13.7559
OCI-Ly10 CTRP1 7.7916 10.0649 4.3055 0.89
KMS-11 CTRP1 7.9175 9.7802 4.4569 0.3575
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.5195 9.066 4.5604 0.3003
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO205 CTRP1 4.6561 5.3532 4.5146 6.8762
C2BBe1 CTRP1 4.7891 7.2095 3.7512 12.9165
DLD-1 CTRP1 5.1314 8.299 3.4989 13.611
SNU-1040 CTRP1 5.8886 8.9894 3.7348 8.8282
SNU-81 CTRP1 6.1178 11.4805 2.6822 16.1575
SNU-C4 CTRP1 6.4756 7.792 4.6161 0.7688
HT-29 CTRP1 6.5057 7.8149 4.6202 0.7194
HT-55 CTRP1 6.5142 8.7613 4.2336 3.1506
LoVo CTRP1 6.5596 9.4608 3.9472 5.2198
SNU-61 CTRP1 6.6465 9.6013 3.9346 5.1128
MDST8 CTRP1 6.6828 8.0388 4.6093 0.6129
SNU-175 CTRP1 6.6868 8.3492 4.4917 1.1889
SW948 CTRP1 6.7019 8.2766 4.5268 0.9853
SW48 CTRP1 6.763 9.1137 4.2137 2.8245
NCI-H508 CTRP1 6.7853 8.3258 4.5436 0.8192
CW-2 CTRP1 6.8651 13.2089 2.3733 15.7654
CL-34 CTRP1 6.8922 9.8356 3.9699 4.3126
SW403 CTRP1 6.9826 8.9395 4.3916 1.3881
SK-CO-1 CTRP1 6.9879 8.7496 4.4678 0.9886
CL-40 CTRP1 7.0512 8.9755 4.4079 1.224
GP2d CTRP1 7.0627 8.6348 4.5415 0.603
HT115 CTRP1 7.0834 8.4797 4.6054 0.3678
LS513 CTRP1 7.1289 8.5688 4.5909 0.3894
LS411N CTRP1 7.1865 8.8046 4.5282 0.5694
SW620 CTRP1 7.272 8.853 4.5437 0.4637
KM12 CTRP1 7.2945 9.1102 4.4589 0.7636
HCT 8 CTRP1 7.3009 8.3337 4.7311 0.0567
RCM-1 [Human ESC] CTRP1 7.3076 8.7278 4.6009 0.2805
HCT 116 CTRP1 7.3415 8.9482 4.5361 0.4507
SNU-C5 CTRP1 7.3567 8.9171 4.5528 0.3914
LS123 CTRP1 7.3801 8.8312 4.5914 0.2766
COLO 678 CTRP1 7.4826 9.4281 4.4169 0.7933
LS180 CTRP1 7.605 9.0485 4.5967 0.1686
RKO CTRP1 7.7989 9.3938 4.5475 0.2352
SW480 CTRP1 7.9179 10.0529 4.3601 0.7129
COLO 320 CTRP1 7.993 10.6969 4.1504 1.5443
SNU-C2A CTRP1 8.2572 10.727 4.2475 0.9052
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2 CTRP1 6.1794 7.9455 4.4078 2.5437
JHH-6 CTRP1 6.2478 7.3712 4.6801 0.681
SNU-398 CTRP1 7.8177 9.898 4.3773 0.6252
SNU-449 CTRP1 8.3592 10.0406 4.5234 0.1454
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EPLC-272H CTRP1 4.8874 7.3656 3.7596 12.4014
NCI-H1299 CTRP1 4.9052 6.6626 4.1256 9.0679
BEN CTRP1 5.087 9.7136 2.7549 19.5993
NCI-H1930 CTRP1 5.1403 7.8397 3.7357 11.5375
ChaGo-K-1 CTRP1 5.1658 7.0065 4.1727 7.5531
NCI-H1105 CTRP1 5.4205 17.6318 -0.9288 33.7705
NCI-H727 CTRP1 5.4818 8.6645 3.5952 11.4188
COR-L51 CTRP1 5.7741 10.7766 2.7721 14.993
DV-90 CTRP1 5.7986 11.2228 2.5696 18.0528
HCC1359 CTRP1 6.1979 7.5189 4.5986 1.2033
NCI-H1781 CTRP1 6.2044 9.7703 3.5759 9.1499
NCI-H460 CTRP1 6.4574 8.0919 4.4886 1.5089
COLO 668 CTRP1 6.4761 8.8536 4.1719 3.6862
NCI-H2029 CTRP1 6.5181 8.2912 4.436 1.7495
NCI-H2126 CTRP1 6.5212 8.3662 4.4063 1.9363
NCI-H82 CTRP1 6.5947 9.402 3.9944 4.7733
Sq-1 CTRP1 6.6671 8.1983 4.542 0.944
CAL-12T CTRP1 6.6789 8.9225 4.2517 2.7123
NCI-H2081 CTRP1 6.6908 11.4976 3.0769 11.5329
SHP-77 CTRP1 6.7317 11.4985 3.1038 11.2172
NCI-H2122 CTRP1 6.8094 8.3645 4.5391 0.8184
NCI-H1876 CTRP1 6.8206 8.3878 4.5349 0.8273
LC-1/sq-SF CTRP1 6.8252 8.3341 4.5571 0.722
COR-L23 CTRP1 6.8926 9.3284 4.1892 2.766
SCLC-21H CTRP1 6.9281 8.3161 4.6048 0.3994
LCLC-103H CTRP1 6.9908 8.101 4.7032 0.156
NCI-H2141 CTRP1 7.0078 8.3842 4.6109 0.3413
NCI-H1435 CTRP1 7.0186 8.8157 4.4555 1.0183
DMS 273 CTRP1 7.0213 8.392 4.6132 0.3755
NCI-H1975 CTRP1 7.0268 8.8795 4.4345 1.114
Lu-99 CTRP1 7.0438 8.2648 4.6659 0.2201
NCI-H1963 CTRP1 7.0869 8.7827 4.4965 0.673
HCC15 CTRP1 7.1317 9.4246 4.2663 1.9141
NCI-H2172 CTRP1 7.1564 8.5715 4.6002 0.3477
HCC44 CTRP1 7.159 9.1106 4.4024 1.1396
NCI-H1694 CTRP1 7.1738 8.5307 4.6208 0.2827
RERF-LC-KJ CTRP1 7.1827 8.642 4.5851 0.3799
HCC2935 CTRP1 7.1841 8.7955 4.5306 0.5623
NCI-H1755 CTRP1 7.1849 10.0357 4.0393 3.274
T3M-10 CTRP1 7.1912 10.7697 3.7238 5.4759
COR-L279 CTRP1 7.1919 8.6518 4.585 0.3754
HCC2108 CTRP1 7.1941 9.4018 4.3041 1.6177
NCI-H650 CTRP1 7.2067 8.6048 4.607 0.3057
VMRC-LCD CTRP1 7.208 8.6963 4.5753 0.397
NCI-H2073 CTRP1 7.2133 10.8235 3.7123 5.512
NCI-H2286 CTRP1 7.2144 8.8107 4.5368 0.5208
NCI-H1573 CTRP1 7.2146 8.7403 4.5622 0.4351
NCI-H3255 CTRP1 7.2215 9.7407 4.1803 2.3071
EBC-1 CTRP1 7.257 8.9286 4.5107 0.5881
NCI-H1792 CTRP1 7.2597 8.8552 4.5382 0.489
NCI-H522 CTRP1 7.2808 8.8357 4.5532 0.4283
NCI-H2342 CTRP1 7.2816 12.2142 3.1203 9.609
NCI-H810 CTRP1 7.286 8.8097 4.5644 0.3913
NCI-H661 CTRP1 7.308 9.2811 4.4005 1.007
NCI-H2030 CTRP1 7.3166 8.9755 4.5168 0.529
NCI-H2009 CTRP1 7.322 9.3378 4.3849 1.0667
HCC33 CTRP1 7.3365 8.7172 4.615 0.2362
NCI-H1915 CTRP1 7.3638 9.0964 4.4914 0.5899
COLO 699 CTRP1 7.3729 11.9723 3.2873 8.2042
HCC4006 CTRP1 7.3752 8.8599 4.5796 0.3083
Calu-3 CTRP1 7.3866 9.3395 4.411 0.8926
HCC827 CTRP1 7.3932 9.228 4.4549 0.7072
NCI-H596 CTRP1 7.4425 9.0168 4.5495 0.3612
HARA [Human squamous cell lung carcinoma] CTRP1 7.4736 9.0231 4.5587 0.323
NCI-H1355 CTRP1 7.4822 9.3752 4.4362 0.7173
NCI-H1437 CTRP1 7.4845 9.3871 4.4328 0.7291
NCI-H1836 CTRP1 7.5128 8.9785 4.5881 0.2377
HCC1195 CTRP1 7.5131 9.0138 4.5761 0.2648
Lu-65 CTRP1 7.5283 9.6444 4.3549 1.0196
NCI-H1568 CTRP1 7.5299 8.9969 4.5879 0.2327
A-549 CTRP1 7.5599 9.6517 4.3652 0.9485
KNS-62 CTRP1 7.5739 9.0818 4.5744 0.2479
NCI-H841 CTRP1 7.5918 9.1334 4.5631 0.2675
NCI-H358 CTRP1 7.6303 9.5928 4.415 0.6974
COR-L88 CTRP1 7.6357 9.3626 4.4994 0.4152
HCC1833 CTRP1 7.6524 9.6954 4.3863 0.7918
HCC78 CTRP1 7.6598 9.4947 4.4617 0.5181
NCI-H441 CTRP1 7.7092 12.831 3.0964 8.7392
NCI-H1666 CTRP1 7.7515 9.8835 4.3565 0.8377
SK-LU-1 CTRP1 7.7662 9.4042 4.5323 0.2783
NCI-H1373 CTRP1 7.7708 14.6946 2.2702 13.8582
NCI-H23 CTRP1 7.773 9.797 4.3965 0.6734
NCI-H2405 CTRP1 7.7896 9.6989 4.438 0.5244
NCI-H1048 CTRP1 7.8138 9.3024 4.5835 0.1645
LXF 289 CTRP1 7.8305 9.5676 4.4991 0.334
Calu-6 CTRP1 7.8436 9.2967 4.5956 0.1391
NCI-H1793 CTRP1 7.9281 9.3782 4.5972 0.1212
LCLC-97TM1 CTRP1 7.969 9.8866 4.4385 0.4364
NCI-H2023 CTRP1 7.9815 9.4057 4.606 0.1014
NCI-H2110 CTRP1 8.0996 10.1971 4.3777 0.5523
NCI-H1944 CTRP1 8.2033 10.074 4.4582 0.299
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 CTRP1 6.7725 8.1568 4.6018 0.5741
KYSE-410 CTRP1 6.8801 8.6661 4.4533 1.1738
KYSE-140 CTRP1 7.7138 9.6463 4.428 0.5993
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COV318 CTRP1 6.4915 7.3851 4.771 0.169
Caov-3 CTRP1 6.6938 9.9281 3.8141 5.9273
A2780 CTRP1 6.771 9.0752 4.2343 2.3382
COV644 CTRP1 6.9073 9.1372 4.2765 2.1722
EFO-21 CTRP1 6.9905 8.2269 4.6598 0.2555
OVMANA CTRP1 7.0096 8.189 4.6798 0.1998
OV7 CTRP1 7.1832 10.1384 3.9947 3.5788
IGROV-1 CTRP1 7.1915 9.4951 4.2658 1.61
SK-OV-3 CTRP1 7.1916 8.5246 4.6294 0.254
OVK18 CTRP1 7.2261 8.8383 4.5314 0.5329
OVKATE CTRP1 7.2459 9.008 4.4772 0.6352
OAW42 CTRP1 7.2653 8.3733 4.7062 0.09
TYK-nu CTRP1 7.3111 9.026 4.4964 0.6055
EFO-27 CTRP1 7.3206 8.8846 4.5508 0.4154
JHOM-1 CTRP1 7.3736 8.8071 4.5973 0.2645
COV434 CTRP1 7.3925 10.0243 4.1462 2.2726
RMG-I CTRP1 7.4934 10.0487 4.1832 1.9262
HEY A8 CTRP1 7.4969 8.8525 4.6253 0.1678
COV362 CTRP1 7.5513 9.2642 4.5027 0.4462
JHOS-4 CTRP1 7.5706 9.0753 4.5755 0.2466
OV-90 CTRP1 7.6472 9.506 4.4529 0.5539
JHOC-5 CTRP1 7.7825 8.9846 4.6778 0.0536
OVCAR-8 CTRP1 7.8432 9.3676 4.5718 0.1553
RMUG-S CTRP1 7.977 10.545 4.2016 1.318
OVCAR-4 CTRP1 7.9959 9.93 4.4332 0.3844
SNU-840 CTRP1 8.2006 10.3405 4.3647 0.5415
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CFPAC-1 CTRP1 5.2736 8.5803 3.4737 13.2453
Panc 03.27 CTRP1 6.6394 8.0778 4.5765 0.801
QGP-1 CTRP1 7.0203 8.7949 4.4642 0.9747
PaTu 8902 CTRP1 7.0238 8.2927 4.649 0.2702
HPAC CTRP1 7.2927 9.3296 4.3756 1.1386
Capan-2 CTRP1 7.3888 9.2838 4.4326 0.7999
SUIT-2 CTRP1 7.5077 8.9391 4.5998 0.2144
HuP-T4 CTRP1 7.612 9.5032 4.4404 0.6173
KP-3 CTRP1 7.696 9.7747 4.3744 0.807
Panc 10.05 CTRP1 7.8788 9.4832 4.5451 0.2171
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP1 6.3038 10.2176 3.4288 10.0207
MSTO-211H CTRP1 7.3473 9.4179 4.365 1.137
NCI-H2052 CTRP1 7.533 9.3249 4.4742 0.5475
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 7.265 8.3553 4.712 0.0826
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-1 CTRP1 5.4796 7.2871 4.273 5.5191
COLO 741 CTRP1 5.9168 9.1197 3.6914 9.1002
SK-MEL-28 CTRP1 6.0389 6.9004 4.7713 0.442
Hs 936.T CTRP1 6.763 8.806 4.3429 1.9697
A-375 CTRP1 6.7712 9.1127 4.2184 2.7778
SK-MEL-5 CTRP1 6.8011 8.3183 4.5531 0.7611
G-361 CTRP1 7.0928 8.9313 4.4429 1.0074
Hs 944.T CTRP1 7.6344 9.1537 4.5713 0.2354
Hs 852.T CTRP1 7.6563 8.9375 4.6513 0.0963
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1080 CTRP1 6.8817 8.7873 4.4063 1.4284
RKN CTRP1 6.8897 8.1845 4.6374 0.3223
G-401 CTRP1 7.2812 10.237 4.0033 3.3495
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS CTRP1 6.5775 7.9128 4.6131 0.6001
MKN7 CTRP1 7.0193 8.8055 4.4597 0.9972
NUGC-4 CTRP1 7.1965 8.7692 4.5449 0.5034
SH-10-TC CTRP1 7.3904 8.2956 4.7726 0.0205
Fu97 CTRP1 7.4854 9.4811 4.3984 0.8671
MKN74 CTRP1 7.5124 10.0006 4.2109 1.7508
SNG-M CTRP1 7.2852 9.0958 4.4605 0.7643
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 CTRP1 7.3271 9.1598 4.4537 0.6655
HSC-2 CTRP1 7.6511 8.9895 4.6323 0.1226
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP1 5.1586 6.7539 4.293 6.5003
RT-4 CTRP1 5.2014 7.349 4.0303 8.6877
UM-UC-3 CTRP1 7.4305 8.9476 4.5692 0.3129
HT-1376 CTRP1 7.7581 9.414 4.5261 0.2955
KMBC-2 CTRP1 8.0922 9.6576 4.56 0.143

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022168)
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.