Details of the Drug

General Information of Drug (ID: DMH4U87)

Drug Name
VX-366
Synonyms Isobutyramide; Isobutyramide, Vertex
Indication
Disease Entry ICD 11 Status REF
Constitutional neutropenia 4B00.0 Discontinued in Phase 2 [1]
Structure 3D Structure is Not Available
3D MOL 2D MOL
Cross-matching ID
UNII
82UOE7B38Z
DrugBank ID
DB17705
TTD ID
D0AL3O

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hemoglobin (HB) TTQO71U HBA_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006007)
2 A combination of hydroxyurea and isobutyramide to induce fetal hemoglobin in transgenic mice is more hematotoxic than the individual agents. Blood Cells Mol Dis. 1999 Jun-Aug;25(3-4):255-69.