Details of the Drug

General Information of Drug (ID: DMH86KO)

Drug Name

PCSK9 Adnectin

Synonyms

PCSK9 Adnectin (cardiovascular); Adnectin program (cardiovascular disease), Adnexus/BMS; PCSK9 Adnectin (cardiovascular), Bristol-Myers Squibb

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Phase 1	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proprotein convertase subtilisin/kexin type 9 (PCSK9)	TTBRG7E	PCSK9_HUMAN	Modulator	[2]

Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Cardiovascular disease

ICD Disease Classification

BA00-BE2Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proprotein convertase subtilisin/kexin type 9 (PCSK9)	DTT	PCSK9	4.82E-02	-0.07	-0.3

Molecular Expression Atlas (MEA)

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References

1	Cholesterol-lowering blockbuster candidates speed into Phase III trials. Nat Rev Drug Discov. 2012 Nov;11(11):817-9.
2	Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering. J Pharmacol Exp Ther. 2014 Aug;350(2):412-24.