Details of the Drug

General Information of Drug (ID: DMHU78R)

Drug Name
6-m-Tolyl-pteridine-2,4,7-triamine
Synonyms
6-(3-methylphenyl)pteridine-2,4,7-triamine; 2853-70-5; UNII-Y75RNL3DWL; Y75RNL3DWL; CHEMBL48189; NSC19443; NSC 19443; 6-m-Tolyl-pteridine-2,4,7-triamine; NSC 639358; AC1Q4WBT; AC1L5FLS; CTK4G1672; DTXSID00182754; ZINC1566881; 6-meta-tolylpteridine-2,7-triamine; NSC639358; NSC-19443; BDBM50127144; 6-(m-tolyl)pteridine-2,4,7-triamine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 267.29
Logarithm of the Partition Coefficient (xlogp) 1.3
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C13H13N7
IUPAC Name
6-(3-methylphenyl)pteridine-2,4,7-triamine
Canonical SMILES
CC1=CC(=CC=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
InChI
InChI=1S/C13H13N7/c1-6-3-2-4-7(5-6)8-10(14)18-12-9(17-8)11(15)19-13(16)20-12/h2-5H,1H3,(H6,14,15,16,18,19,20)
InChIKey
YCKFHKBIDNIARX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
227595
CAS Number
2853-70-5
TTD ID
D0A8HX

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Polypeptide deformylase (PDF) TT9SL3Q DEFM_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Polypeptide deformylase (PDF) DTT PDF 8.87E-16 -0.54 -0.86
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36.