Details of the Drug

General Information of Drug (ID: DMHYW5E)

Drug Name

ME-143

Synonyms

ME-143; 852536-39-1; VXHSDGZMRLGSEJ-UHFFFAOYSA-N; SCHEMBL243810; NV143; ME143; KB-145995; Z-3309; 3,4-bis(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C21H18O4
Canonical SMILES: C1C(C(C2=C(O1)C=C(C=C2)O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
InChI: 1S/C21H18O4/c22-15-5-1-13(2-6-15)19-12-25-20-11-17(24)9-10-18(20)21(19)14-3-7-16(23)8-4-14/h1-11,19,21-24H,12H2
InChIKey: VXHSDGZMRLGSEJ-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 11151778
TTD ID: D0O9LN

References

1	A first-in-human dose-escalation study of ME-143, a second generation NADH oxidase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2014; 32(1): 87-93.