Details of the Drug

General Information of Drug (ID: DMI1O54)

• Drug Name: 2,5-dideoxy-2,5-imino-D-altritol
• Synonyms: CHEMBL469844; 172823-15-3; CHEMBL10437; SCHEMBL2435520; CTK0A7803; DTXSID40437432; ZINC5766623; 2,5-Imino-2,5-dideoxy-D-altritol; BDBM50241865; BDBM50099008; (2R,3S,4S)-2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol; 2,5-Pyrrolidinedimethanol, 3,4-dihydroxy-, (2R,3R,4S,5R)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 163.17
  Logarithm of the Partition Coefficient (xlogp); -1.8
  Rotatable Bond Count (rotbonds); 2
  Hydrogen Bond Donor Count (hbonddonor); 5
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C6H13NO4
  IUPAC Name: (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
  Canonical SMILES: C([C@@H]1[C@H]([C@H]([C@H](N1)CO)O)O)O
  InChI: InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6+/m1/s1
  InChIKey: PFYHYHZGDNWFIF-KAZBKCHUSA-N
• Cross-matching ID:
  PubChem CID: 10261406
  ChEBI ID: CHEMBL469844
  CAS Number: 172823-15-3
  TTD ID: D0SQ1T
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alpha-galactosidase A (GLA)	TTIS03D	AGAL_HUMAN	Inhibitor	[1]
Lactase-phlorizin hydrolase (LCT)	TTA0OSE	LPH_HUMAN	Inhibitor	[1]

References

• [1] 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4.