Details of the Drug

General Information of Drug (ID: DMI783H)

Drug Name
Vonvendi
Synonyms Vonicog alfa
Indication
Disease Entry ICD 11 Status REF
Von willebrand disease 3B12 Approved [1]
Affected Organisms
Humans
Drug Type
Recombinant protein
ADMET Property
Clearance
The clearance of drug is 0.029 L/h/kg [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 21.9 hours [2]
Vd
The volume of distribution (Vd) of drug is 0.80 L [2]
Cross-matching ID
UNII
5PKM8P0G5I
DrugBank ID
DB12872
TTD ID
D4Y0SB

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
von Willebrand factor (VWF) TT3SZBT VWF_HUMAN Replacement [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Von willebrand disease
ICD Disease Classification 3B12
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
von Willebrand factor (VWF) DTT VWF 2.96E-01 2.47 2.08
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of Vonvendi.
2 Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease. Blood. 2015 Oct 22;126(17):2038-46. doi: 10.1182/blood-2015-02-629873. Epub 2015 Aug 3.