General Information of Drug (ID: DMI7CYZ)

Drug Name
Amiselimod
Synonyms
Amiselimod; 942399-20-4; Amiselimod [INN]; Amiselimod free base; Amiselimod(MT-1303) free base; 942399-20-4 (free base); 358M5150LY; 2-amino-2-(4-(heptyloxy)-3-(trifluoromethyl)phenethyl)propane-1,3-diol; 2-Amino-2-(2-(4-heptyloxy-3-trifluoromethylphenyl)ethyl)propane-1,3-diol; 2-amino-2-[2-[4-heptoxy-3-(trifluoromethyl)phenyl]ethyl]propane-1,3-diol; 2-Amino-2-{2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl}propane-1,3-diol; UNII-358M5150LY; Amiselimod,MT1303; Amiselimod (USAN/INN); AMISELIMOD [USAN]; AMISELIMOD [WHO-DD]; MT-1303 FREE BASE; GTPL9319; SCHEMBL2463680; CHEMBL3707375; JVCPIJKPAKAIIP-UHFFFAOYSA-N; DTXSID301141402; BCP24738; EX-A1427; MT1303; AKOS032971355; Example 1 [US20090137530]; D10905; MT-1303; MT1303; MT 1303; Q27256444; 1,3-PROPANEDIOL, 2-AMINO-2-(2-(4-(HEPTYLOXY)-3-(TRIFLUOROMETHYL)PHENYL)ETHYL)-; 2-Amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-1,3-propanediol
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Phase 2 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C19H30F3NO3
Canonical SMILES
CCCCCCCOC1=C(C=C(C=C1)CCC(CO)(CO)N)C(F)(F)F
InChI
InChI=1S/C19H30F3NO3/c1-2-3-4-5-6-11-26-17-8-7-15(12-16(17)19(20,21)22)9-10-18(23,13-24)14-25/h7-8,12,24-25H,2-6,9-11,13-14,23H2,1H3
InChIKey
JVCPIJKPAKAIIP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
16129483
UNII
358M5150LY
DrugBank ID
DB17074
TTD ID
D2E4CG

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine-1-phosphate receptor 2 (S1PR2) TTVSMOH S1PR2_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04857112) A Phase 2, Randomized, Double-Blinded, Placebo Controlled, Parallel Group Study Evaluating the Efficacy and Safety of Amiselimod (MT-1303) in Subjects With Mild to Moderate Ulcerative Colitis (UC). U.S.National Institutes of Health.
2 Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2017 Jan;174(1):15-27.