Details of the Drug

General Information of Drug (ID: DMI9Q6L)

• Drug Name: Tefinostat
• Synonyms: CHR-2845; CHR-2847; CHR-2875; Small molecule inhibitor (hematological malignancies), Chroma

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• Drug Type: Small molecular drug
• Chemical Identifiers:
  Formula: C28H37N3O5
  Canonical SMILES: C1CCC(C1)OC(=O)C(C2=CC=CC=C2)NCC3=CC=C(C=C3)NC(=O)CCCCCCC(=O)NO
  InChI: 1S/C28H37N3O5/c32-25(14-6-1-2-7-15-26(33)31-35)30-23-18-16-21(17-19-23)20-29-27(22-10-4-3-5-11-22)28(34)36-24-12-8-9-13-24/h3-5,10-11,16-19,24,27,29,35H,1-2,6-9,12-15,20H2,(H,30,32)(H,31,33)/t27-/m0/s1
  InChIKey: GLNWREBYRLDPQP-MHZLTWQESA-N
• Cross-matching ID:
  PubChem CID: 15940949
  CAS Number: 914382-60-8
  UNII: ZAU91150SB
  DrugBank ID: DB15321
  TTD ID: D09TLE

References

• [1] ClinicalTrials.gov (NCT00820508) Safety and Tolerability of CHR-2845 to Treat Haematological Diseases or Lymphoid Malignancies. U.S. National Institutes of Health.