Details of the Drug

General Information of Drug (ID: DMIK6C9)

Drug Name
Zibotentan
Synonyms
ZD4054; ZD-4054; ZD4054, Zibotentan; Zibotentan (JAN/INN); Trans,trans-2(4-methoxyphenyl)-4-(1-3-benzodiazol-5-yl)-1-(dibutylaminocarbonylmethyl)pyrrolidine-3-carboxylic acid; N-(3-methoxy-5-methyl-pyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Discontinued in Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 424.4
Logarithm of the Partition Coefficient (xlogp) 1.4
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C19H16N6O4S
IUPAC Name
N-(3-methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
Canonical SMILES
CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4
InChI
InChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChIKey
FJHHZXWJVIEFGJ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9910224
ChEBI ID
CHEBI:94573
CAS Number
186497-07-4
UNII
8054MM4902
DrugBank ID
DB06629
TTD ID
D02HVW
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endothelin A receptor (EDNRA) TTKRD0G EDNRA_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Gene/Protein Processing [3]
Endothelin-converting enzyme 1 (ECE1) OTPFHC6F ECE1_HUMAN Gene/Protein Processing [3]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Prostate
The Studied Disease Prostate cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Endothelin A receptor (EDNRA) DTT EDNRA 3.19E-05 -2.69 -1.71
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 6.3217 8.8628 3.422 2.3589
CHSA8926 GDSC1 5.6096 8.5304 3.1695 5.3317
EW-24 GDSC1 5.6849 6.9153 3.9097 0.5885
ES6 GDSC1 6.0576 8.1845 3.5736 1.8626
SK-PN-DW GDSC1 6.0695 7.9804 3.6627 1.3674
EW-7 GDSC1 6.1576 10.4665 2.6115 7.9482
A-673 GDSC1 6.1906 7.4756 3.9047 0.2934
TC-71 GDSC1 6.2711 8.2783 3.6362 1.2776
CAL-72 GDSC1 6.3068 7.9097 3.7927 0.5812
ES8 GDSC1 6.334 8.5242 3.5669 1.5536
ES4 GDSC1 6.3743 10.049 2.934 5.3227
MG-63 GDSC1 6.4142 8.1046 3.7637 0.6137
SK-ES-1 GDSC1 6.4218 7.9487 3.8235 0.4131
NOS-1 [Human HNSCC] GDSC1 6.4888 9.1694 3.3772 2.3815
ES7 GDSC1 6.5159 11.083 2.5477 7.5673
EW-1 GDSC1 6.6302 8.9914 3.5161 1.4822
CAL-78 GDSC1 6.6371 8.4566 3.723 0.6135
U2OS GDSC1 6.6547 9.7513 3.2165 3.0685
CHSA0108 GDSC1 6.7249 8.7842 3.6369 0.8689
CHSA0011 GDSC1 6.7639 10.309 3.0351 3.9812
CADO-ES1 GDSC1 6.766 8.1455 3.8804 0.1584
SJSA-1 GDSC1 6.7717 8.6938 3.6894 0.6452
EW-18 GDSC1 6.7781 15.4141 0.6654 17.7431
H-EMC-SS GDSC1 6.8512 10.6938 2.9151 4.5692
G-292 clone A141B1 GDSC1 6.8629 8.5228 3.7853 0.3214
EW-11 GDSC1 6.9497 10.0563 3.2358 2.551
HuO9 GDSC1 6.9514 9.0588 3.6267 0.7489
EW-3 GDSC1 6.9647 10.894 2.8892 4.5355
ES5 GDSC1 6.9801 9.8459 3.3355 1.9922
EW-16 GDSC1 6.9958 9.2781 3.5631 0.9533
SaOS-2 GDSC1 6.9977 8.6373 3.7944 0.255
NY GDSC1 7.0229 8.7836 3.7528 0.3385
ES1 GDSC1 7.0246 8.7243 3.7741 0.2894
HOS GDSC1 7.0297 8.3568 3.8999 0.0848
HuO-3N1 GDSC1 7.2789 9.3007 3.6658 0.4535
EW-13 GDSC1 7.3044 9.239 3.6969 0.3658
MHH-ES-1 GDSC1 7.3707 9.3982 3.6655 0.416
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 144 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 6.8087 8.4931 3.7758 0.3667
L-428 GDSC1 2.6797 3.7046 2.6529 20.6975
LAMA-84 GDSC1 4.849 7.4497 3.1726 7.3139
ALL-SIL GDSC1 4.9623 12.3017 0.8524 22.1004
ST486 GDSC1 5.0413 9.4546 2.3277 12.9824
Farage GDSC1 5.076 8.0567 3.0396 7.6606
MC116 GDSC1 5.2833 6.2249 4.0027 0.5401
HT GDSC1 5.4321 7.2224 3.659 2.3217
SIG-M5 GDSC1 5.4787 6.9082 3.8182 1.2695
HAL-01 GDSC1 5.4957 8.5584 3.0838 6.2177
SCC-3 GDSC1 5.5099 6.7977 3.8783 0.9068
MOLP-8 GDSC1 5.6021 9.6642 2.6277 9.2232
SU-DHL-5 GDSC1 5.6165 6.846 3.907 0.6597
OCI-AML-5 GDSC1 5.6553 6.9045 3.9012 0.6505
MY-M12 GDSC1 5.6792 7.7607 3.5585 2.534
P31/FUJ GDSC1 5.6952 6.9387 3.9052 0.5989
OCI-AML-3 GDSC1 5.7126 7.4134 3.7238 1.4845
SU-DHL-10 GDSC1 5.7707 6.5746 4.0649 0.0863
A3/Kawakami GDSC1 5.7934 6.9671 3.9349 0.4119
HL-60 GDSC1 5.8045 7.0254 3.9178 0.4661
TUR GDSC1 5.8256 7.543 3.725 1.332
ML-2 GDSC1 5.8468 10.1494 2.56 9.0582
OPM-2 GDSC1 5.8509 7.5008 3.754 1.1513
WSU-DLCL2 GDSC1 5.8531 6.9128 3.9777 0.2468
Jiyoye GDSC1 5.855 7.8274 3.6218 1.869
Raji GDSC1 5.8603 7.4045 3.7965 0.9329
PF-382 GDSC1 5.8879 8.7753 3.2253 4.3449
Daudi GDSC1 5.9024 7.4408 3.8009 0.871
BL-41 GDSC1 5.9105 7.3566 3.8369 0.7052
Karpas-299 GDSC1 5.9269 7.803 3.6673 1.5159
EM-2 GDSC1 5.9277 11.6549 1.8921 13.2623
RPMI-8866 GDSC1 5.933 8.5211 3.3643 3.3363
VL51 GDSC1 5.9401 9.8513 2.7614 7.4328
AMO1 GDSC1 5.9594 7.4447 3.824 0.7182
NB4 GDSC1 5.9653 7.0036 3.9872 0.1796
CCRF-CEM GDSC1 5.9785 7.5024 3.8101 0.7611
697 GDSC1 5.991 7.5743 3.7878 0.8474
KY821 GDSC1 5.9977 7.826 3.6914 1.3029
Ramos.2G6.4C10 GDSC1 6.0029 7.4861 3.8266 0.672
RL GDSC1 6.0039 7.4527 3.8396 0.6192
Loucy GDSC1 6.0233 8.1613 3.5662 1.9512
OCI-M1 GDSC1 6.0237 7.3203 3.8966 0.4013
A4/Fukuda GDSC1 6.0387 8.3337 3.5016 2.3057
HEL GDSC1 6.039 13.0266 1.3043 16.4245
DB GDSC1 6.0442 10.3713 2.5839 8.405
THP-1 GDSC1 6.0617 7.9192 3.6836 1.2702
RC-K8 GDSC1 6.0736 7.4217 3.8792 0.4293
KMS-12-BM GDSC1 6.0844 8.0195 3.6539 1.3956
BE-13 GDSC1 6.0885 8.7889 3.3321 3.2689
ME1 GDSC1 6.0891 11.5312 2.0624 11.7509
SUP-M2 GDSC1 6.0892 7.3448 3.913 0.3171
KOPN-8 GDSC1 6.0894 8.2872 3.5466 1.9714
HH [Human lymphoma] GDSC1 6.0978 8.8886 3.2936 3.4979
KE-37 GDSC1 6.0983 7.8266 3.7366 0.9775
H9 GDSC1 6.1068 7.8263 3.7405 0.952
YT GDSC1 6.1156 7.7792 3.7625 0.8467
MLMA GDSC1 6.1159 8.6656 3.4001 2.7989
Karpas-422 GDSC1 6.1201 7.989 3.6825 1.2119
JVM-2 GDSC1 6.1248 9.1631 3.1874 4.1372
EB2 GDSC1 6.1468 7.9692 3.7023 1.0891
CA46 GDSC1 6.1494 8.1519 3.6309 1.4386
MOLM-13 GDSC1 6.1556 14.5284 0.6545 19.4442
BALL-1 GDSC1 6.1698 8.1004 3.6608 1.265
BC-3 GDSC1 6.19 9.6461 3.0085 5.1959
MOLT-4 GDSC1 6.1936 7.8108 3.7834 0.6964
HC-1 GDSC1 6.203 8.6763 3.4406 2.422
BV-173 GDSC1 6.2051 8.1636 3.6518 1.2716
OCI-AML-2 GDSC1 6.2118 7.2238 3.9989 0.0943
JJN-3 GDSC1 6.2148 7.7496 3.8149 0.5626
Hs 445 GDSC1 6.2154 7.7131 3.8286 0.514
K-562 GDSC1 6.2373 7.9237 3.7589 0.7602
SU-DHL-1 GDSC1 6.2491 7.6027 3.8816 0.33
CTV-1 GDSC1 6.2518 8.1659 3.6718 1.1278
SU-DHL-8 GDSC1 6.2619 13.2028 1.3759 15.416
EJM GDSC1 6.2626 9.2767 3.2138 3.7178
MOLT-13 GDSC1 6.2659 8.1002 3.7035 0.9702
WIL2 NS GDSC1 6.2744 8.3959 3.5908 1.4998
LP-1 GDSC1 6.2779 10.2256 2.797 6.429
P12-Ichikawa GDSC1 6.2788 7.5276 3.919 0.2236
Karpas-620 GDSC1 6.2829 7.5625 3.9083 0.2469
OCI-Ly19 GDSC1 6.2855 8.1466 3.6941 0.9939
U-698-M GDSC1 6.3054 8.0649 3.7339 0.8073
L-540 GDSC1 6.3436 8.1867 3.7037 0.9016
U266B1 GDSC1 6.3446 8.1649 3.7124 0.8643
KCL-22 GDSC1 6.3702 8.4916 3.5965 1.3659
Namalwa GDSC1 6.3811 8.021 3.7813 0.5731
RPMI-8226 GDSC1 6.3837 9.0694 3.3665 2.5907
P32/ISH GDSC1 6.3877 7.5962 3.9343 0.1588
SU-DHL-4 GDSC1 6.4069 7.7522 3.8875 0.2499
MHH-PREB-1 GDSC1 6.4114 7.945 3.8209 0.4266
KM-H2 GDSC1 6.4257 8.6569 3.556 1.5054
ARH-77 GDSC1 6.4388 8.7956 3.5064 1.7436
JURL-MK1 GDSC1 6.452 8.6912 3.5544 1.4849
SU-DHL-16 GDSC1 6.4562 7.8826 3.8599 0.2975
Karpas-45 GDSC1 6.4597 8.2727 3.7196 0.7456
Reh GDSC1 6.4624 14.9521 0.6678 18.5496
DEL GDSC1 6.4715 12.4835 1.8635 12.0186
SUP-T1 GDSC1 6.4757 8.2207 3.7455 0.6383
WSU-NHL GDSC1 6.4827 7.9656 3.8405 0.3365
CESS GDSC1 6.5 12.9699 1.6508 13.2189
L-363 GDSC1 6.5058 7.7553 3.9217 0.1512
SU-DHL-6 GDSC1 6.5136 8.2969 3.7325 0.6596
MN-60 GDSC1 6.5276 8.5914 3.6271 1.071
KMS-11 GDSC1 6.5286 8.7502 3.5656 1.3499
MOLT-16 GDSC1 6.5441 7.7727 3.9291 0.1302
Mono-Mac-6 GDSC1 6.5559 10.2581 2.9439 4.9121
P30/OHK GDSC1 6.5593 8.3118 3.7453 0.5856
JVM-3 GDSC1 6.5784 9.0392 3.4733 1.751
LC4-1 GDSC1 6.5883 9.7391 3.1874 3.342
DND-41 GDSC1 6.6071 14.2922 1.0887 16.0642
NU-DUL-1 GDSC1 6.6125 8.2698 3.7812 0.4419
SR GDSC1 6.6285 13.3457 1.5573 13.4387
HDLM-2 GDSC1 6.6378 8.2512 3.7975 0.3837
Granta-519 GDSC1 6.6708 8.2881 3.7968 0.3708
JSC-1 GDSC1 6.6837 8.8362 3.5999 1.0521
RPMI-8402 GDSC1 6.6939 9.0254 3.5311 1.347
NOMO-1 GDSC1 6.6988 7.9151 3.9344 0.0939
SUP-HD1 GDSC1 6.7019 8.518 3.7261 0.5646
RPMI-6666 GDSC1 6.7078 8.3124 3.8019 0.3415
TK [Human B-cell lymphoma] GDSC1 6.7113 7.9996 3.9106 0.1235
SK-MM-2 GDSC1 6.7284 8.5701 3.7175 0.5772
CTB-1 GDSC1 6.7621 8.6579 3.6987 0.6195
EoL-1 GDSC1 6.7812 8.1603 3.8807 0.1544
MV4-11 GDSC1 6.7893 8.4023 3.8005 0.313
VAL GDSC1 6.7958 8.6249 3.7238 0.5197
L-1236 GDSC1 6.8086 8.9481 3.6098 0.9116
ATN-1 GDSC1 6.8327 8.3259 3.8425 0.2086
PL-21 GDSC1 6.8437 10.3491 3.0598 3.7053
SUP-B15 GDSC1 6.8717 9.1714 3.5516 1.0968
DG-75 GDSC1 6.8768 10.5052 3.0103 3.9489
KMOE-2 GDSC1 6.8801 8.5485 3.7826 0.3213
QIMR-WIL GDSC1 6.9045 8.6768 3.7466 0.4022
ROS-50 GDSC1 6.9274 9.1222 3.5934 0.887
KG-1 GDSC1 6.9275 8.5121 3.8124 0.2399
Ku812 GDSC1 6.9307 8.8164 3.7068 0.5013
GDM-1 GDSC1 7.008 14.117 1.4413 13.1726
NKM-1 GDSC1 7.0839 9.0028 3.6983 0.4523
BC-1 GDSC1 7.1688 8.685 3.8381 0.1382
Sc-1 GDSC1 7.1831 8.4828 3.9096 0.0584
ALL-PO GDSC1 7.2964 10.3242 3.2894 1.8766
GR-ST GDSC1 7.5297 9.7021 3.6175 0.4726
RS4;11 GDSC1 8.149 19.3536 -0.2935 18.671
NALM-6 GDSC1 8.2146 17.1377 0.7947 13.8322
MEG-01 GDSC1 8.3056 24.1547 -2.5025 25.3191
⏷ Show the Full List of 144 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1 6.1274 8.0361 3.6671 1.2801
KYAE-1 GDSC1 6.2522 8.0197 3.7286 0.8735
KYSE-50 GDSC1 6.2649 7.9124 3.7746 0.6772
OACP4 C GDSC1 6.6654 9.949 3.1379 3.5183
SK-GT-4 GDSC1 6.6734 8.603 3.6836 0.7295
ESO-51 GDSC1 6.8195 8.614 3.7369 0.4686
KYSE-220 GDSC1 6.9987 9.2577 3.5719 0.9172
OACM5.1 C GDSC1 7.1147 14.6266 1.2698 13.8555
HCE-4 GDSC1 7.3251 8.8507 3.8361 0.1141
FLO-1 GDSC1 7.3897 10.094 3.419 1.2205
TE-12 GDSC1 7.4112 10.2242 3.3785 1.3696
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 5.9657 9.7077 2.8445 6.797
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1 5.4021 6.8548 3.8021 1.4736
Kelly GDSC1 5.4807 8.7289 2.9932 6.913
NH-12 GDSC1 5.5932 7.7822 3.5013 3.0643
CHP-212 GDSC1 5.7077 8.9788 3.0222 6.1504
LA-N-6 GDSC1 5.7603 7.4341 3.7383 1.3419
SiMa GDSC1 5.8778 8.5795 3.3074 3.8135
SJNB-5 GDSC1 5.8955 7.8362 3.6383 1.718
GOTO GDSC1 5.9954 8.0027 3.6184 1.6957
SK-N-FI GDSC1 6.0644 8.4587 3.4617 2.5054
SK-N-BE(2)-M17 GDSC1 6.2091 7.9456 3.7387 0.8678
SK-N-DZ GDSC1 6.2594 7.7092 3.8473 0.4264
KP-N-YN GDSC1 6.2916 8.7604 3.4498 2.2421
SK-N-SH GDSC1 6.3449 8.656 3.5187 1.7923
MHH-NB-11 GDSC1 6.3508 8.0484 3.7589 0.6747
IMR-5 GDSC1 6.3932 7.8532 3.8468 0.3599
CHP-134 GDSC1 6.3962 7.8646 3.8439 0.3667
NB69 GDSC1 6.4312 8.7223 3.5324 1.6183
SJNB-17 GDSC1 6.4676 9.1741 3.3647 2.4815
CHP-126 GDSC1 6.468 8.034 3.8106 0.4282
SJNB-6 GDSC1 6.5076 8.0784 3.8098 0.4106
SJNB-14 GDSC1 6.5577 8.0718 3.831 0.3295
SJNB-13 GDSC1 6.5646 8.3645 3.728 0.642
SJNB-10 GDSC1 6.576 8.3266 3.7465 0.5715
TGW GDSC1 6.6865 8.2802 3.8054 0.3415
SJNB-7 GDSC1 6.708 8.0947 3.8773 0.1779
NB(TU)1 GDSC1 6.7119 8.208 3.8398 0.2508
SJNB-12 GDSC1 6.7334 8.8258 3.6247 0.9101
NB1 GDSC1 6.8738 16.1582 0.372 18.8561
SK-N-AS GDSC1 6.8777 8.4184 3.8268 0.226
KP-N-YS GDSC1 7.0115 8.7401 3.7638 0.317
GI-ME-N GDSC1 7.3673 9.656 3.5723 0.6813
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 6.0276 7.9315 3.6628 1.4162
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 GDSC1 5.4731 8.4355 3.1272 5.9588
CAL-120 GDSC1 5.562 7.0284 3.8092 1.2092
HCC70 GDSC1 5.9027 10.6647 2.3515 10.3376
MRK-nu-1 GDSC1 5.9494 7.6403 3.7434 1.0957
MDA-MB-175-VII GDSC1 5.9802 7.8709 3.665 1.4615
BT-474 GDSC1 6.0615 14.0258 0.8323 18.841
EFM-19 GDSC1 6.081 11.667 1.9918 12.2214
DU4475 GDSC1 6.1028 7.507 3.8595 0.4778
CAL-148 GDSC1 6.1037 7.5488 3.8445 0.5299
HCC1500 GDSC1 6.1685 8.3609 3.5548 1.8198
MDA-MB-361 GDSC1 6.2023 8.2347 3.6221 1.4225
JIMT-1 GDSC1 6.2224 7.8534 3.7792 0.6909
Evsa-T GDSC1 6.2275 7.7872 3.8061 0.5858
HCC38 GDSC1 6.253 8.137 3.6837 1.0717
HCC1419 GDSC1 6.2912 7.8137 3.8217 0.4908
ZR-75-30 GDSC1 6.3091 8.3778 3.6139 1.3458
BT-549 GDSC1 6.3193 8.5467 3.551 1.6531
UACC-812 GDSC1 6.3254 8.3653 3.6263 1.2687
BT-20 GDSC1 6.3387 7.9581 3.7876 0.5785
CAMA-1 GDSC1 6.3723 7.9351 3.8093 0.4844
OCUB-M GDSC1 6.429 8.1501 3.7528 0.6431
MCF-7 GDSC1 6.4742 8.6249 3.5906 1.2869
HCC2157 GDSC1 6.5056 8.1226 3.7931 0.4614
HCC1428 GDSC1 6.5209 8.0609 3.8211 0.3721
MFM-223 GDSC1 6.5536 8.0291 3.8444 0.2972
HCC1599 GDSC1 6.5733 8.3031 3.754 0.5482
MDA-MB-468 GDSC1 6.5945 8.3719 3.7372 0.5914
Hs 578T GDSC1 6.6218 8.5887 3.6678 0.8257
HCC1187 GDSC1 6.6228 8.5851 3.6695 0.8182
HCC1569 GDSC1 6.6312 9.2915 3.396 2.092
MDA-MB-453 GDSC1 6.6609 8.511 3.7125 0.6348
HDQ-P1 GDSC1 6.6788 8.4889 3.7277 0.5729
MDA-MB-436 GDSC1 6.7045 8.7464 3.6427 0.8616
CAL-51 GDSC1 6.7676 8.5129 3.7533 0.4466
EFM-192A GDSC1 6.8053 13.0549 1.811 11.5279
COLO 824 GDSC1 6.8268 8.804 3.6708 0.6745
HCC1937 GDSC1 6.8541 8.8938 3.6486 0.7348
MDA-MB-415 GDSC1 6.8542 8.3037 3.8576 0.1756
UACC-893 GDSC1 6.9165 9.1945 3.5617 1.0193
HCC202 GDSC1 6.9284 11.3473 2.6701 5.9516
AU565 GDSC1 6.9295 9.49 3.4536 1.4753
MDA-MB-231 GDSC1 6.9527 8.7212 3.7488 0.3759
HCC1806 GDSC1 6.999 8.4593 3.8554 0.1467
BT-483 GDSC1 7.0403 9.7757 3.3908 1.658
MDA-MB-330 GDSC1 7.0425 9.0696 3.6586 0.5889
HCC1954 GDSC1 7.0728 8.8807 3.7372 0.3571
YMB-1-E GDSC1 7.1306 8.9818 3.723 0.369
CAL-85-1 GDSC1 7.332 9.8118 3.5011 0.9464
MDA-MB-157 GDSC1 7.3639 9.0532 3.7817 0.1821
HCC1395 GDSC1 7.4192 9.4176 3.6766 0.3711
T-47D GDSC1 7.5343 13.8847 1.8783 9.5389
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-247MG GDSC1 5.0561 8.6881 2.7164 10.1342
GaMG GDSC1 5.6716 8.8715 3.0495 6.0415
YKG-1 GDSC1 5.6771 8.815 3.0793 5.8169
NMC-G1 GDSC1 5.7098 8.5097 3.2405 4.6104
LN-18 GDSC1 5.7863 6.6222 4.0542 0.1002
U-251MG GDSC1 5.7865 8.1895 3.4292 3.1794
CAS-1 GDSC1 5.7966 10.6097 2.306 10.9254
Hs 683 GDSC1 5.8058 7.3162 3.8068 0.9392
U-118MG GDSC1 5.816 7.7796 3.6222 1.9231
SF126 GDSC1 5.8161 7.1366 3.8808 0.6006
SF295 GDSC1 5.825 7.0687 3.91 0.4805
YH-13 GDSC1 5.8262 7.7001 3.6607 1.6863
Becker GDSC1 5.8449 10.2891 2.4922 9.5299
ONS-76 GDSC1 5.8604 7.9276 3.5823 2.0938
D-263MG GDSC1 5.9154 7.5194 3.7759 0.9747
KNS-81-FD GDSC1 6.0704 7.8526 3.714 1.1111
Daoy GDSC1 6.1162 7.6555 3.8098 0.6513
D-566MG GDSC1 6.1636 8.0611 3.6736 1.2092
DK-MG GDSC1 6.202 7.851 3.7717 0.7364
GI-1 GDSC1 6.2141 8.2517 3.6207 1.4164
D-392MG GDSC1 6.2141 9.3577 3.1513 4.2067
LNZTA3WT4 GDSC1 6.2711 9.0936 3.2979 3.1766
AM-38 GDSC1 6.3239 9.3547 3.213 3.6167
SF539 GDSC1 6.3492 9.7154 3.0685 4.4933
H4 GDSC1 6.3598 8.4415 3.6116 1.3035
SK-MG-1 GDSC1 6.3629 8.0813 3.7516 0.6937
KNS-42 GDSC1 6.3865 7.8326 3.8516 0.3496
D-542MG GDSC1 6.4309 7.8754 3.8531 0.3258
SW1783 GDSC1 6.4752 8.5446 3.6224 1.1393
U-87MG ATCC GDSC1 6.5229 11.5422 2.3397 8.9025
D283 Med GDSC1 6.5533 7.9609 3.8681 0.2423
LN-229 GDSC1 6.5812 8.2738 3.7677 0.4995
SF268 GDSC1 6.5931 11.038 2.6147 6.9667
D-502MG GDSC1 6.6085 8.7702 3.593 1.1478
M059J GDSC1 6.6283 8.1158 3.8415 0.276
MOG-G-CCM GDSC1 6.6299 8.819 3.5834 1.171
PFSK-1 GDSC1 6.6911 8.924 3.5693 1.1775
LN-405 GDSC1 6.7069 8.1052 3.8733 0.1854
T98G GDSC1 6.726 8.9461 3.5758 1.1182
KINGS-1 GDSC1 6.8184 8.7796 3.6764 0.6606
DBTRG-05MG GDSC1 6.8229 8.6068 3.7407 0.4558
Onda 10 GDSC1 6.879 8.9316 3.6446 0.7325
D-423MG GDSC1 6.8999 9.7044 3.3552 1.9838
KALS-1 GDSC1 6.9273 9.1244 3.5926 0.8904
MOG-G-UVW GDSC1 6.9438 8.499 3.8227 0.2152
D-336MG GDSC1 6.9567 9.574 3.4328 1.5451
SW1088 GDSC1 6.9667 9.3111 3.5385 1.0733
A-172 GDSC1 6.9685 8.6882 3.7662 0.3272
42-MG-BA GDSC1 6.9688 8.7927 3.7296 0.4191
KS-1 [Human Krukenberg tumour] GDSC1 7.0083 9.4816 3.4911 1.2366
Onda 11 GDSC1 7.0597 8.973 3.6997 0.4594
GB-1 GDSC1 7.1706 16.2225 0.5457 17.336
SNB-75 GDSC1 7.3054 9.5403 3.5902 0.6591
8-MG-BA GDSC1 7.3074 9.1949 3.7133 0.3273
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 6.3816 8.3311 3.6644 1.0381
ETK-1 GDSC1 6.7468 8.5333 3.738 0.5023
TGBC1TKB GDSC1 6.9736 8.4263 3.8577 0.1485
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1 6.2348 8.6493 3.4679 2.2181
RL95-2 GDSC1 6.532 7.9306 3.8709 0.2433
EN GDSC1 6.6186 8.0704 3.8538 0.2517
KLE GDSC1 6.6466 9.0031 3.5189 1.4519
ESS-1 GDSC1 6.65 8.319 3.7779 0.4331
AN3-CA GDSC1 6.9641 9.0559 3.6328 0.7193
MFE-296 GDSC1 7.0385 8.6661 3.7991 0.2335
MFE-280 GDSC1 7.5085 9.8477 3.5577 0.6504
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB GDSC1 5.2558 8.9297 2.7423 9.3553
A-498 GDSC1 5.6063 7.2406 3.743 1.522
BFTC-909 GDSC1 6.0183 7.5133 3.8227 0.6754
KTCTL-1M GDSC1 6.0836 8.2139 3.5742 1.8243
SW13 GDSC1 6.0865 7.7576 3.7583 0.891
KTCTL-26A GDSC1 6.3495 8.0577 3.7549 0.6909
KTCTL-195 GDSC1 6.367 8.1842 3.7145 0.8372
HA7-RCC GDSC1 6.3914 8.4713 3.6141 1.2594
KMRC-1 GDSC1 6.3922 8.0228 3.7851 0.553
KMRC-20 GDSC1 6.4366 8.052 3.7919 0.5037
TK-10 GDSC1 6.4473 8.5417 3.6113 1.2171
A-704 GDSC1 6.4605 8.4563 3.6502 1.0298
OS-RC-2 GDSC1 6.4717 7.9303 3.8489 0.3193
KTCTL-13 GDSC1 6.5847 8.6825 3.6165 1.0662
LB2241-RCC GDSC1 6.5973 8.4693 3.7024 0.7125
SN12C GDSC1 6.6148 8.592 3.6637 0.8471
KTCTL-21 GDSC1 6.6186 9.8688 3.1478 3.5329
BB65-RCC GDSC1 6.6664 8.3637 3.7681 0.4534
VMRC-RCW GDSC1 6.6964 8.5228 3.7222 0.5806
UO-31 GDSC1 6.8555 8.8422 3.6681 0.6659
786-O GDSC1 6.8694 13.72 1.5386 12.9567
SW156 GDSC1 6.8879 8.8821 3.6663 0.6522
VMRC-RCZ GDSC1 6.8898 8.5662 3.78 0.3238
769-P GDSC1 6.9028 8.5396 3.794 0.2868
CAL-54 GDSC1 6.9703 9.1244 3.61 0.7957
LB996-RCC GDSC1 6.9735 8.914 3.6881 0.535
NCC021 GDSC1 7.0636 9.1409 3.6409 0.6329
ACHN GDSC1 7.1063 8.6566 3.8261 0.1689
LB1047-RCC GDSC1 7.115 9.374 3.5759 0.822
KTCTL-140 GDSC1 7.1762 9.0671 3.71 0.3832
Caki-1 GDSC1 7.3763 9.7803 3.5305 0.8133
RXF 393L GDSC1 7.9475 9.8948 3.7002 0.1837
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT115 GDSC1 5.2122 6.5017 3.854 1.4553
C2BBe1 GDSC1 5.4209 8.8272 2.9062 7.7018
COLO205 GDSC1 5.7021 7.2709 3.7771 1.2063
GP5d GDSC1 5.8189 8.3487 3.3768 3.4641
SNU-175 GDSC1 5.8385 8.0754 3.5076 2.5858
LS411N GDSC1 5.8672 7.6785 3.6896 1.4706
SW948 GDSC1 5.8927 7.7613 3.6679 1.5566
LS1034 GDSC1 5.9918 7.5282 3.8059 0.7677
SW1116 GDSC1 6.0815 7.5732 3.8264 0.6127
SW1463 GDSC1 6.0829 8.3496 3.5173 2.1488
LS123 GDSC1 6.1479 7.8531 3.7479 0.8814
SNU-61 GDSC1 6.1822 9.105 3.245 3.6597
HT-29 GDSC1 6.2123 7.5792 3.876 0.3638
HCT 116 GDSC1 6.2323 7.7272 3.8301 0.4982
SW48 GDSC1 6.2585 7.9738 3.7488 0.7843
SNU-407 GDSC1 6.2643 8.9913 3.3382 2.9404
MDST8 GDSC1 6.2836 10.6924 2.5852 7.8349
HT-55 GDSC1 6.3532 7.9253 3.8054 0.5083
SNU-1040 GDSC1 6.406 7.6118 3.9354 0.1521
KM12 GDSC1 6.4276 7.9234 3.8348 0.3775
SNU-C1 GDSC1 6.4428 8.1075 3.774 0.5595
LS513 GDSC1 6.55 8.1062 3.8159 0.3729
SW620 GDSC1 6.5556 8.7867 3.5633 1.3336
NCI-H716 GDSC1 6.5676 9.0792 3.4521 1.8732
COLO 678 GDSC1 6.5831 8.8492 3.551 1.364
SW626 GDSC1 6.584 8.566 3.6607 0.8829
SNU-81 GDSC1 6.6086 8.373 3.7424 0.5657
LS180 GDSC1 6.6301 8.1501 3.8302 0.3022
SW1417 GDSC1 6.6952 8.5123 3.7256 0.5701
SNU-C5 GDSC1 6.7161 8.5358 3.7252 0.5595
NCI-H747 GDSC1 6.78 8.9785 3.5864 1.0283
CaR-1 GDSC1 6.8041 8.5413 3.757 0.4189
T84 GDSC1 6.8234 9.5113 3.3973 1.8578
CCK-81 GDSC1 6.871 9.1419 3.5626 1.0521
HCC2998 GDSC1 6.8953 8.6389 3.7565 0.3799
COLO 320HSR GDSC1 6.9377 8.7537 3.7318 0.4272
LoVo GDSC1 7.0036 8.9747 3.6778 0.5505
RKO GDSC1 7.0664 8.8569 3.7432 0.3451
RCM-1 [Human ESC] GDSC1 7.0946 8.6782 3.8147 0.1902
CW-2 GDSC1 7.2579 9.3768 3.6308 0.5606
CL-11 GDSC1 7.2757 9.3222 3.657 0.4784
SW837 GDSC1 7.2815 9.1949 3.7039 0.3578
SNU-C2B GDSC1 8.0118 10.539 3.5017 0.5693
HCT 15 GDSC1 8.2728 18.0213 0.4184 15.4435
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 6.6301 8.2643 3.7899 0.4083
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-387 GDSC1 5.5832 8.42 3.2043 5.1444
JHH-6 GDSC1 5.6506 6.6612 3.9905 0.3114
HuH-1 GDSC1 6.017 7.3972 3.8657 0.5114
SK-HEP-1 GDSC1 6.1411 7.412 3.9087 0.3049
Hep 3B2.1-7 GDSC1 6.1411 7.6703 3.8145 0.615
SNU-398 GDSC1 6.168 8.3406 3.5629 1.7762
Hep-G2/C3A GDSC1 6.2128 7.6572 3.848 0.4504
JHH-1 GDSC1 6.2204 7.3721 3.9516 0.1729
Huh-7 GDSC1 6.3274 8.4987 3.5741 1.5247
SNU-475 GDSC1 6.3456 7.4512 3.9687 0.1117
JHH-2 GDSC1 6.4484 8.1431 3.7632 0.5933
HLE GDSC1 6.6048 8.4232 3.7224 0.6358
JHH-7 GDSC1 6.6773 8.3789 3.7669 0.4516
JHH-4 GDSC1 7.0996 8.5373 3.8637 0.1164
SNU-423 GDSC1 7.1208 8.7596 3.7963 0.2161
SNU-449 GDSC1 7.4047 9.2067 3.744 0.2362
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 170 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1781 GDSC1 4.3003 9.5551 1.6872 19.8122
Lu-139 GDSC1 4.8144 9.2217 2.2694 14.1294
NCI-H2444 GDSC1 5.0604 6.3857 3.8211 1.9429
BEN GDSC1 5.2679 7.1451 3.5991 3.0487
NCI-H1755 GDSC1 5.4912 7.3804 3.6221 2.4552
SBC-1 GDSC1 5.5006 7.2506 3.684 2.0417
NCI-H748 GDSC1 5.5875 8.0235 3.3892 3.837
SHP-77 GDSC1 5.6195 8.6141 3.1367 5.542
SBC-5 GDSC1 5.6221 6.6536 3.982 0.3568
NCI-H720 GDSC1 5.6436 6.996 3.8604 0.8497
NCI-H1876 GDSC1 5.6689 10.7266 2.1609 12.2478
NCI-H1092 GDSC1 5.6788 7.5104 3.6661 1.8679
COLO 668 GDSC1 5.761 10.2226 2.4676 9.9186
COR-L88 GDSC1 5.777 7.7173 3.6287 1.943
NCI-H2196 GDSC1 5.8344 7.9448 3.5615 2.2589
NCI-H661 GDSC1 5.873 8.5174 3.3323 3.6568
NCI-H1793 GDSC1 5.9557 7.5249 3.7916 0.863
HARA [Human squamous cell lung carcinoma] GDSC1 5.9941 8.0066 3.6161 1.7099
COR-L95 GDSC1 6.0236 7.7748 3.7237 1.1134
HCC44 GDSC1 6.0254 12.8038 1.4032 15.9086
NCI-H2291 GDSC1 6.0309 8.0541 3.6144 1.6712
NCI-H292 GDSC1 6.0334 7.5528 3.8141 0.6986
NCI-H1694 GDSC1 6.0428 8.0966 3.6027 1.7203
NCI-H1648 GDSC1 6.0549 8.5618 3.4126 2.8209
NCI-H1436 GDSC1 6.0795 7.7351 3.764 0.8722
NCI-H226 GDSC1 6.0804 7.4798 3.8607 0.4881
NCI-H1770 GDSC1 6.0928 7.8178 3.7377 0.978
NCI-H838 GDSC1 6.0934 7.5052 3.8565 0.4943
NCI-H2342 GDSC1 6.111 8.6436 3.407 2.7647
NCI-H345 GDSC1 6.111 7.2116 3.9677 0.1735
NCI-H1915 GDSC1 6.1189 8.1229 3.6283 1.4878
NCI-H2029 GDSC1 6.139 7.6295 3.8288 0.563
SK-LU-1 GDSC1 6.1408 7.8976 3.7276 0.9781
NCI-H526 GDSC1 6.1439 7.5744 3.8512 0.481
COR-L23 GDSC1 6.1494 7.6851 3.8123 0.6171
NCI-H1963 GDSC1 6.164 7.9299 3.7252 0.9671
ABC-1 GDSC1 6.1768 9.0649 3.2596 3.5764
NCI-H2369 GDSC1 6.1907 8.4538 3.5273 1.9425
NCI-H2135 GDSC1 6.1922 12.2116 1.806 13.084
NCI-H209 GDSC1 6.2271 8.3812 3.5746 1.6398
RERF-LC-KJ GDSC1 6.2364 8.0756 3.7003 1.012
LCLC-103H GDSC1 6.2385 7.6469 3.8617 0.3931
Lu-135 GDSC1 6.2407 8.08 3.7004 1.0072
NCI-H460 GDSC1 6.2443 7.4609 3.9296 0.2117
HCC33 GDSC1 6.2525 8.0322 3.724 0.8932
NCI-H187 GDSC1 6.2569 7.4818 3.9269 0.2133
COR-L321 GDSC1 6.264 7.9988 3.7416 0.8093
NCI-H2171 GDSC1 6.2683 7.6496 3.8721 0.3475
NCI-H2170 GDSC1 6.28 8.0602 3.725 0.8654
UMC-11 GDSC1 6.2954 7.9773 3.7628 0.7001
NCI-H2731 GDSC1 6.3024 8.3597 3.6181 1.3324
NCI-H520 GDSC1 6.3159 8.2056 3.6845 1.0091
EPLC-272H GDSC1 6.3218 8.723 3.4801 2.0311
NCI-H2009 GDSC1 6.3322 8.31 3.651 1.1455
NCI-H2085 GDSC1 6.3386 8.3379 3.6429 1.1766
DMS 53 GDSC1 6.3389 8.2778 3.6665 1.0682
NCI-H596 GDSC1 6.3398 8.4901 3.5833 1.4642
NCI-H2803 GDSC1 6.3476 8.5845 3.549 1.6299
NCI-H1693 GDSC1 6.3487 9.0122 3.3728 2.605
NCI-H64 GDSC1 6.3514 7.4959 3.9556 0.131
NCI-H2795 GDSC1 6.3563 8.8138 3.4594 2.1
COR-L303 GDSC1 6.3677 7.541 3.946 0.1432
NCI-H1975 GDSC1 6.3716 8.271 3.6833 0.9646
NCI-H3255 GDSC1 6.3773 8.5524 3.5756 1.4613
NCI-H2227 GDSC1 6.3918 8.0556 3.7728 0.5961
NCI-H196 GDSC1 6.3947 7.6054 3.9336 0.1582
NCI-H2722 GDSC1 6.4015 8.6094 3.5639 1.4927
Ms-1 GDSC1 6.4042 7.9623 3.8118 0.4583
DMS 273 GDSC1 6.4148 9.3132 3.2791 3.062
NCI-H2122 GDSC1 6.4311 8.1735 3.745 0.6703
NCI-H1836 GDSC1 6.4326 7.7428 3.9 0.2133
NCI-H522 GDSC1 6.4353 9.4138 3.2467 3.2252
NCI-H847 GDSC1 6.458 7.8829 3.8605 0.2954
Lu-165 GDSC1 6.4612 7.7109 3.9211 0.1634
SK-MES-1 GDSC1 6.4968 8.367 3.6995 0.7958
NCI-H2141 GDSC1 6.4982 7.9415 3.8548 0.2936
NCI-H1435 GDSC1 6.5024 8.0571 3.8154 0.3968
NCI-H841 GDSC1 6.5042 8.0076 3.8337 0.3452
NCI-H1568 GDSC1 6.5063 8.2796 3.736 0.6519
DMS 114 GDSC1 6.5066 8.0589 3.8164 0.3921
CPC-N GDSC1 6.5081 8.6694 3.5882 1.2642
LK-2 GDSC1 6.5142 8.4776 3.6649 0.9215
NCI-H1688 GDSC1 6.5211 8.4838 3.6655 0.9136
DMS 79 GDSC1 6.5275 14.3325 1.0143 16.657
HCC78 GDSC1 6.5301 8.4992 3.6634 0.9147
NCI-H810 GDSC1 6.5325 7.9141 3.8768 0.2303
Calu-6 GDSC1 6.5356 8.2865 3.7452 0.6007
NCI-H1573 GDSC1 6.5435 8.1781 3.7877 0.4579
SW1573 GDSC1 6.5553 8.7584 3.5743 1.2827
NCI-H1792 GDSC1 6.5632 8.3792 3.722 0.6644
NCI-H2405 GDSC1 6.5657 8.519 3.6708 0.8565
NCI-H1623 GDSC1 6.5711 8.3218 3.7463 0.5751
NCI-H1666 GDSC1 6.5722 8.452 3.6986 0.7441
CAL-12T GDSC1 6.5746 8.3623 3.7328 0.6188
NCI-H2804 GDSC1 6.5782 9.025 3.479 1.7225
NCI-H510A GDSC1 6.5803 8.2654 3.7704 0.4915
NCI-H2347 GDSC1 6.5909 8.733 3.5998 1.1338
HOP-62 GDSC1 6.5935 8.3284 3.7527 0.5407
NCI-H1993 GDSC1 6.6003 8.7806 3.5854 1.1892
ChaGo-K-1 GDSC1 6.6035 8.8248 3.5696 1.2577
EMC-BAC-1 GDSC1 6.6066 9.2102 3.4174 2.0089
LC-2/ad GDSC1 6.6088 13.3671 1.5339 13.6219
NCI-H2461 GDSC1 6.6342 9.155 3.4527 1.7923
NCI-H2373 GDSC1 6.6417 8.5528 3.6894 0.7299
NCI-H1563 GDSC1 6.6513 8.2588 3.7998 0.3711
Lu-99A GDSC1 6.6783 9.0267 3.5237 1.397
NCI-H1581 GDSC1 6.679 8.1248 3.8567 0.2257
NCI-H69 GDSC1 6.6878 8.7312 3.6415 0.8789
NCI-H2595 GDSC1 6.6895 8.9155 3.5719 1.1676
NCI-H647 GDSC1 6.696 8.8307 3.6072 1.011
NCI-H650 GDSC1 6.6975 8.8069 3.6169 0.9699
EBC-1 GDSC1 6.7009 8.4458 3.7519 0.4843
NCI-H446 GDSC1 6.7026 8.0306 3.8971 0.1457
RERF-LC-MS GDSC1 6.7051 8.36 3.7841 0.3896
NCI-H82 GDSC1 6.7156 8.0716 3.8878 0.1579
PC-14 GDSC1 6.722 8.4405 3.7618 0.4442
NCI-H1355 GDSC1 6.7308 8.6961 3.6722 0.732
NCI-H1437 GDSC1 6.7363 8.4704 3.7566 0.4525
NCI-H1304 GDSC1 6.7456 8.2023 3.8539 0.2114
COR-L311 GDSC1 6.7543 8.4933 3.7552 0.4475
IA-LM GDSC1 6.7568 8.5532 3.7347 0.5072
NCI-H1048 GDSC1 6.7593 8.3114 3.8212 0.2758
NCI-H513 GDSC1 6.7756 8.413 3.7917 0.3399
HCC827 GDSC1 6.7814 8.6927 3.6936 0.625
Lu-65 GDSC1 6.785 8.2811 3.8409 0.2255
NCI-H2818 GDSC1 6.7858 8.4806 3.7716 0.3874
LC-1/sq GDSC1 6.7873 8.8115 3.6522 0.7664
SW1271 GDSC1 6.7937 8.5514 3.7495 0.4449
Lu-134-A GDSC1 6.8168 8.9833 3.6 0.9442
NCI-H441 GDSC1 6.8199 8.8817 3.6393 0.7914
NCI-H1299 GDSC1 6.8236 10.1127 3.1498 3.207
NCI-H3122 GDSC1 6.8239 8.9843 3.6026 0.9284
NCI-H2110 GDSC1 6.8356 9.2844 3.4925 1.3876
NCI-H524 GDSC1 6.8384 8.7272 3.7033 0.5604
NCI-H2081 GDSC1 6.858 8.532 3.7803 0.3353
A-549 GDSC1 6.8715 8.7455 3.7095 0.5235
LOU-NH91 GDSC1 6.8722 8.2983 3.8657 0.1579
NCI-H358 GDSC1 6.8775 9.2756 3.5141 1.2521
NCI-H2172 GDSC1 6.898 8.439 3.827 0.2198
PaCa-3 GDSC1 6.9078 9.2922 3.5208 1.1967
NCI-H1734 GDSC1 6.9141 8.8231 3.698 0.5362
NCI-H2023 GDSC1 6.9142 8.5403 3.7979 0.2744
Calu-3 GDSC1 6.9142 8.7748 3.7154 0.4843
NCI-H1651 GDSC1 6.9193 8.8092 3.705 0.5124
NCI-H322M GDSC1 6.9262 8.91 3.6712 0.6136
LXF 289 GDSC1 6.9454 9.0216 3.638 0.7134
NCI-H2869 GDSC1 6.9663 11.1153 2.7936 5.1169
NCI-H1838 GDSC1 6.9744 8.6446 3.7835 0.2856
NCI-H23 GDSC1 6.9806 8.7357 3.7541 0.3517
NCI-H1869 GDSC1 7.0176 8.8152 3.7398 0.3722
NCI-H2030 GDSC1 7.0221 13.0233 1.9627 10.1277
NCI-H727 GDSC1 7.0316 8.5917 3.822 0.1933
LCLC-97TM1 GDSC1 7.0318 8.9762 3.6881 0.5057
NCI-H1155 GDSC1 7.0472 8.5409 3.8446 0.1529
NCI-H1703 GDSC1 7.0875 9.044 3.685 0.4875
IST-SL1 GDSC1 7.089 9.9335 3.3504 1.8002
A-427 GDSC1 7.1204 9.4674 3.5433 0.9378
NCI-H1944 GDSC1 7.1597 9.129 3.682 0.4626
EKVX GDSC1 7.161 9.6018 3.5096 1.0374
EMC-BAC-2 GDSC1 7.1799 9.1881 3.6686 0.4902
HCC15 GDSC1 7.1894 9.3465 3.6153 0.644
NCI-H2087 GDSC1 7.1913 9.5702 3.5339 0.9231
COR-L105 GDSC1 7.2924 11.1347 2.9568 3.6308
SBC-3 GDSC1 7.3129 8.9808 3.7884 0.1827
NCI-H2591 GDSC1 7.3136 9.4269 3.6341 0.5242
HOP-92 GDSC1 7.3633 9.6125 3.5865 0.6391
NCI-H1650 GDSC1 7.4276 9.1807 3.7608 0.2013
NCI-H211 GDSC1 7.4473 9.1529 3.777 0.1716
NCI-H2228 GDSC1 7.4916 10.0463 3.4785 0.9209
RERF-LC-Sq1 GDSC1 7.5182 9.9657 3.5186 0.7678
⏷ Show the Full List of 170 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 6.2616 14.093 0.9434 17.729
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-4 GDSC1 5.9393 7.7327 3.7018 1.3175
COLO 680N GDSC1 6.3269 7.9603 3.782 0.6061
TE-6 GDSC1 6.4085 8.4616 3.6255 1.1891
KYSE-450 GDSC1 6.4221 7.8633 3.8541 0.3269
KYSE-180 GDSC1 6.4276 8.2048 3.7318 0.7222
KYSE-510 GDSC1 6.4577 7.9251 3.8455 0.3342
OE19 GDSC1 6.5176 7.7099 3.9411 0.1176
OE33 GDSC1 6.6089 9.0671 3.4763 1.7014
TE-9 GDSC1 6.6309 8.1004 3.8479 0.2606
KYSE-150 GDSC1 6.6391 7.8313 3.9421 0.0941
KYSE-70 GDSC1 6.6738 8.4623 3.7354 0.5507
TE-10 GDSC1 6.7528 8.3897 3.7914 0.3498
TE-1 GDSC1 6.8397 8.5313 3.7738 0.3588
TE-5 GDSC1 6.884 8.4009 3.835 0.2085
KYSE-270 GDSC1 6.8888 8.8446 3.6804 0.6054
T.T GDSC1 6.953 8.5017 3.825 0.2083
TE-11 GDSC1 7.0267 8.4872 3.8555 0.1408
OE21 GDSC1 7.1306 9.0441 3.7012 0.4243
EC-GI-10 GDSC1 7.2506 9.0127 3.7557 0.2567
KYSE-520 GDSC1 7.426 9.8377 3.5291 0.7878
KYSE-140 GDSC1 7.4353 9.4165 3.6828 0.3512
TE-8 GDSC1 7.4661 9.36 3.7133 0.2771
TE-15 GDSC1 7.5343 9.4786 3.6969 0.2894
KYSE-410 GDSC1 7.5617 9.4867 3.7039 0.268
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES-2 GDSC1 4.4241 5.6034 3.7642 4.0421
DOV13 GDSC1 5.6518 7.2246 3.772 1.2971
TYK-nu GDSC1 5.8879 8.087 3.5287 2.375
OV56 GDSC1 5.9486 6.9568 3.9973 0.1632
TOV-21G GDSC1 5.9831 7.6351 3.7606 0.9787
OAW42 GDSC1 6.0863 7.7737 3.752 0.9193
EFO-21 GDSC1 6.2542 7.9971 3.7381 0.8319
OVCAR-3 GDSC1 6.2793 8.1434 3.6927 1.0062
OVISE GDSC1 6.3212 7.489 3.9474 0.1527
JHOS-2 GDSC1 6.4272 7.7774 3.8861 0.2458
OVCAR-5 GDSC1 6.4356 8.2718 3.71 0.8013
OVK18 GDSC1 6.445 8.5309 3.6145 1.2042
FU-OV-1 GDSC1 6.5264 8.4406 3.684 0.8343
RMG-I GDSC1 6.54 9.69 3.1832 3.4438
TOV-112D GDSC1 6.5666 8.8732 3.5342 1.4613
EFO-27 GDSC1 6.5695 11.7721 2.2618 9.2954
SK-OV-3 GDSC1 6.5977 8.5784 3.6617 0.8682
IGROV-1 GDSC1 6.6345 9.5488 3.2914 2.6654
Caov-3 GDSC1 6.6358 8.3134 3.7745 0.4502
Kuramochi GDSC1 6.7314 8.8624 3.61 0.9707
OV-90 GDSC1 6.7512 8.7178 3.6723 0.7178
OC 314 GDSC1 6.7753 7.9719 3.9415 0.0748
OVTOKO GDSC1 6.8205 8.9605 3.6101 0.9015
A2780 GDSC1 6.8307 9.2006 3.5229 1.2557
Caov-4 GDSC1 6.9845 8.9566 3.677 0.5631
OVCAR-4 GDSC1 7.1113 9.0425 3.6945 0.4505
OAW28 GDSC1 7.1489 9.5224 3.5344 0.9511
OVCAR-8 GDSC1 7.5822 14.8887 1.4453 11.8582
OVKATE GDSC1 9.3083 21.8628 -0.7226 17.9322
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaTu 8902 GDSC1 5.8628 7.1059 3.9115 0.4497
KP-4 GDSC1 5.8699 9.72 2.7781 7.4842
PaTu 8988t GDSC1 5.9578 7.5153 3.7962 0.8403
Panc 08.13 GDSC1 5.9808 8.5034 3.3982 3.0348
SU.86.86 GDSC1 6.1616 7.4551 3.9011 0.3164
MIA PaCa-2 GDSC1 6.2006 7.8246 3.7811 0.7001
HPAF-II GDSC1 6.2604 8.9034 3.3737 2.7323
Capan-1 GDSC1 6.2932 8.3955 3.5996 1.4341
Hs 766T GDSC1 6.2955 7.8692 3.8031 0.5517
PSN1 GDSC1 6.3452 8.1564 3.7159 0.8491
KP-2 GDSC1 6.4171 7.5754 3.9516 0.1226
DAN-G GDSC1 6.4443 8.1951 3.7423 0.6711
HPAC GDSC1 6.4719 8.0385 3.8104 0.4266
YAPC GDSC1 6.4813 8.1368 3.7785 0.5214
PL4 GDSC1 6.5928 8.1336 3.8223 0.3372
Capan-2 GDSC1 6.593 8.696 3.6149 1.0659
HuP-T4 GDSC1 6.5932 9.2951 3.3762 2.2475
Panc 04.03 GDSC1 6.6435 8.9959 3.5203 1.4482
HuP-T3 GDSC1 6.6567 8.9956 3.5263 1.4064
QGP-1 GDSC1 6.678 17.249 -0.2988 22.1343
SW1990 GDSC1 6.7239 8.6262 3.6952 0.6549
Panc 03.27 GDSC1 6.7367 8.0682 3.8963 0.1396
SUIT-2 GDSC1 6.8669 11.0284 2.7769 5.3975
Panc 02.03 GDSC1 6.9115 11.8713 2.4247 7.5228
CFPAC-1 GDSC1 6.9606 8.9407 3.6735 0.5872
AsPC-1 GDSC1 6.9822 10.5275 3.0554 3.52
MZ-PC-1 GDSC1 6.9931 9.9278 3.3087 2.1137
KP-3 GDSC1 7.0042 9.1403 3.6177 0.7464
Panc 10.05 GDSC1 7.0443 9.2481 3.594 0.804
BxPC-3 GDSC1 7.4805 10.1437 3.4378 1.0779
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 5.6931 7.7049 3.5902 2.3101
MSTO-211H GDSC1 6.2871 8.2976 3.6357 1.263
NCI-H2052 GDSC1 6.345 8.1148 3.7316 0.7854
IST-Mes1 GDSC1 6.5604 8.6224 3.6292 1.0329
NCI-H2452 GDSC1 6.9545 8.9179 3.6794 0.5719
NCI-H28 GDSC1 7.2227 9.0392 3.7366 0.3047
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PC-3 GDSC1 6.5403 9.0069 3.4686 1.82
VCaP GDSC1 6.5833 7.8433 3.9189 0.1376
LNCaP clone FGC GDSC1 7.2091 17.6358 -0.1094 20.0757
22Rv1 GDSC1 7.3514 9.1465 3.7457 0.2474
DU145 GDSC1 7.4197 8.8434 3.8701 0.0677
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 7.1841 9.1017 3.7007 0.4031
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-28 GDSC1 5.3216 6.3795 3.9589 0.711
IGR-1 GDSC1 5.3658 7.1216 3.6666 2.3938
UACC-62 GDSC1 5.4296 7.5271 3.5212 3.2524
Mel Ho GDSC1 5.5151 6.9791 3.8067 1.2853
LB2518-MEL GDSC1 5.6278 7.2543 3.748 1.4635
SK-MEL-24 GDSC1 5.6793 7.4177 3.7054 1.6357
CP66-MEL GDSC1 5.6805 7.6566 3.6044 2.2424
A2058 GDSC1 5.7448 6.7668 3.9887 0.2666
VMRC-MELG GDSC1 5.7765 7.4058 3.7576 1.2195
COLO 783 GDSC1 5.7824 7.1381 3.866 0.6911
IGR-37 GDSC1 5.8673 7.2342 3.8653 0.6229
Hs 938.T GDSC1 5.9367 7.5731 3.7643 1.0082
WT2-iPS GDSC1 5.9409 7.2911 3.8743 0.5322
SK-MEL-5 GDSC1 6.0164 7.3771 3.8729 0.4861
Hs 940.T GDSC1 6.0254 7.7391 3.7386 1.04
A101D GDSC1 6.0511 7.1219 3.9772 0.1728
SK-MEL-1 GDSC1 6.0533 7.6952 3.768 0.878
SK-MEL-30 GDSC1 6.0573 7.3838 3.8867 0.4143
WM1552C GDSC1 6.1102 7.9921 3.6767 1.2509
LB373-MEL-D GDSC1 6.119 7.505 3.8667 0.4439
CP50-MEL-B GDSC1 6.1571 7.6886 3.8142 0.6047
SK-MEL-2 GDSC1 6.1715 7.4064 3.922 0.2568
IPC-298 GDSC1 6.1846 7.2703 3.9738 0.1408
RVH-421 GDSC1 6.1929 8.0465 3.6925 1.0896
MZ-MEL-7 GDSC1 6.2238 7.8652 3.7754 0.7047
GAK GDSC1 6.2429 7.6063 3.8779 0.3432
G-mel GDSC1 6.2586 7.843 3.798 0.5943
G-361 GDSC1 6.2636 7.774 3.8254 0.4952
COLO 679 GDSC1 6.2705 8.0046 3.7422 0.8017
MeWo GDSC1 6.3433 7.7876 3.8513 0.371
MMAc-SF GDSC1 6.3467 7.7511 3.8656 0.3294
RPMI-7951 GDSC1 6.3665 7.8668 3.8317 0.417
CHL-1 GDSC1 6.4015 8.1464 3.743 0.6986
A-375 GDSC1 6.4029 8.0734 3.7707 0.5963
IST-MEL1 GDSC1 6.4041 8.2928 3.6888 0.9133
COLO 829 GDSC1 6.4086 8.2716 3.6988 0.8681
LOX-IMVI GDSC1 6.4168 7.9083 3.8361 0.3791
SK-MEL-3 GDSC1 6.4791 7.7706 3.9071 0.1848
A-431 GDSC1 6.5011 8.1117 3.7953 0.4571
WM115 GDSC1 6.5174 7.7625 3.9233 0.1456
COLO 800 GDSC1 6.5801 8.3832 3.7273 0.6346
COLO 792 GDSC1 6.5872 8.4157 3.7182 0.6623
HT-144 GDSC1 6.6092 8.2044 3.8033 0.3807
WM278 GDSC1 6.6346 11.682 2.3442 8.6228
DJM-1 GDSC1 6.6831 8.8724 3.5858 1.1128
Mel JuSo GDSC1 6.6926 8.3177 3.7944 0.3674
SH-4 GDSC1 6.7051 8.7866 3.6278 0.9201
WM793 GDSC1 6.9389 8.6593 3.7655 0.34
M14 GDSC1 6.9426 8.3907 3.8589 0.1531
MZ-MEL-2 GDSC1 7.0261 9.0319 3.6659 0.5752
451Lu GDSC1 7.0505 8.7177 3.7857 0.2566
HMV-II GDSC1 7.128 9.6466 3.4789 1.1871
A-388 GDSC1 7.1767 9.0148 3.7284 0.339
WM35 GDSC1 7.2267 12.1335 2.4889 6.5125
UACC-257 GDSC1 10.4978 23.4386 -0.7113 15.7662
EquiPSC Line K2 GDSC1 6.7769 9.3262 3.4498 1.6486
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 5.8834 7.8029 3.6462 1.6901
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN GDSC1 5.9287 7.2896 3.8699 0.5579
TE 441.T GDSC1 6.0787 7.4765 3.8612 0.4874
EW-8 GDSC1 6.0927 7.5544 3.838 0.5611
MES-SA GDSC1 6.1471 7.3192 3.9435 0.2143
SW684 GDSC1 6.2727 7.82 3.8121 0.5348
SK-LMS-1 GDSC1 6.3332 8.0089 3.7665 0.6588
Rh30 GDSC1 6.3423 8.0664 3.7487 0.7199
SW982 GDSC1 6.3538 8.2095 3.6993 0.9115
GCT GDSC1 6.4239 7.9479 3.8246 0.4089
HT-1080 GDSC1 6.4616 7.9003 3.8557 0.306
VA-ES-BJ GDSC1 6.6215 7.7684 3.957 0.0792
KYM-1 GDSC1 6.6425 8.2587 3.7965 0.384
Hs 633.T GDSC1 6.6448 8.2191 3.8114 0.3434
Rh41 GDSC1 6.8381 8.2787 3.8604 0.1747
RD GDSC1 6.9756 10.214 3.1833 2.8036
MFH-ino GDSC1 7.1093 8.7538 3.7942 0.223
SK-UT-1 GDSC1 7.1216 8.7003 3.8167 0.1806
G-401 GDSC1 7.1955 9.1646 3.6828 0.4447
SW872 GDSC1 7.3214 9.047 3.769 0.2131
A-204 GDSC1 7.5086 9.9193 3.5318 0.7308
G-402 GDSC1 7.6759 9.5617 3.7184 0.2133
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 746.T GDSC1 5.0648 6.6203 3.717 2.6569
MKN45 GDSC1 5.6028 6.3893 4.0688 0.1233
SCH GDSC1 5.8468 7.0916 3.9103 0.4644
23132/87 GDSC1 6.152 8.0211 3.6842 1.17
MKN1 GDSC1 6.1957 7.7391 3.8111 0.5893
NCI-N87 GDSC1 6.3021 8.5529 3.5403 1.7299
SNU-16 GDSC1 6.3881 7.5446 3.9519 0.1286
AGS GDSC1 6.5083 7.7418 3.9271 0.1414
NUGC-4 GDSC1 6.5177 8.3509 3.7141 0.7246
RERF-GC-1B GDSC1 6.5486 9.813 3.1348 3.7255
SNU-1 GDSC1 6.5538 8.8379 3.5423 1.4353
GCIY GDSC1 6.557 8.4472 3.6942 0.7718
SNU-5 GDSC1 6.6124 7.9492 3.8932 0.1743
OCUM-1 GDSC1 6.6453 8.9276 3.5479 1.3169
IM95 GDSC1 6.6459 8.848 3.5791 1.1752
HSC-39 GDSC1 6.6943 8.1449 3.8553 0.2239
ECC10 GDSC1 6.809 8.6801 3.709 0.5588
MKN7 GDSC1 6.8098 8.6206 3.7308 0.4914
HGC-27 GDSC1 6.8128 8.2793 3.8514 0.1974
MKN28 GDSC1 6.821 9.344 3.4627 1.5409
RF-48 GDSC1 6.9594 8.8772 3.6959 0.5189
TGBC11TKB GDSC1 6.9626 8.6469 3.7785 0.3009
NUGC-3 GDSC1 6.9825 8.8581 3.7115 0.4625
Fu97 GDSC1 6.9973 8.6544 3.7884 0.2676
TMK-1 GDSC1 7.0411 9.0426 3.6678 0.5613
SNG-M GDSC1 6.6021 8.2321 3.7907 0.4193
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-62 GDSC1 5.9067 7.306 3.8546 0.6349
8305C GDSC1 6.0856 7.5197 3.848 0.5297
WRO GDSC1 6.1705 7.7359 3.802 0.6412
B-CPAP GDSC1 6.1965 7.3992 3.9337 0.2192
ASH-3 GDSC1 6.3482 7.8788 3.8204 0.4624
FTC-133 GDSC1 6.3524 7.6307 3.9099 0.2184
CGTH-W-1 GDSC1 6.3528 8.2413 3.6866 0.9666
ML-1 [Human leukemia] GDSC1 6.3652 8.0637 3.7591 0.664
BHT-101 GDSC1 6.4457 7.8795 3.8571 0.3089
K5 GDSC1 6.4659 9.0187 3.4283 2.1278
TT2609-C02 GDSC1 6.485 9.0555 3.4224 2.135
IHH-4 GDSC1 6.5813 8.4846 3.6902 0.7696
TT GDSC1 6.5826 8.2924 3.7615 0.5185
8505C GDSC1 6.6704 10.473 2.9128 4.9005
KMH-2 GDSC1 6.7352 8.599 3.7097 0.5991
HTC-C3 GDSC1 7.0454 8.6239 3.8159 0.2004
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-25 GDSC1 5.5286 7.4242 3.6235 2.3798
Detroit 562 GDSC1 5.8488 7.8946 3.5904 2.063
KON GDSC1 5.867 8.3144 3.4187 3.1022
PCI-15A GDSC1 5.868 9.037 3.0943 5.2838
HSC-2 GDSC1 5.87 7.3093 3.8378 0.7364
SCC-9 GDSC1 5.9119 8.1473 3.5154 2.4183
CAL-27 GDSC1 6.0497 7.0597 3.998 0.1324
FaDu GDSC1 6.201 7.5382 3.8864 0.3392
SCC-4 GDSC1 6.2899 8.1706 3.6867 1.023
BICR 22 GDSC1 6.3114 7.7871 3.8393 0.4232
HSC-4 GDSC1 6.3289 7.776 3.85 0.3818
HO-1-N-1 GDSC1 6.4071 8.1068 3.7601 0.6316
PCI-30 GDSC1 6.4587 8.2718 3.7196 0.7464
BICR 10 GDSC1 6.4783 8.5516 3.621 1.1427
OSC-19 GDSC1 6.4914 8.34 3.7074 0.7692
BHY GDSC1 6.5679 8.2062 3.787 0.4474
BB49-HNC GDSC1 6.6097 8.6666 3.6333 0.9741
CAL-33 GDSC1 6.6113 8.4193 3.7265 0.6177
JHU-011 GDSC1 6.6708 8.7518 3.6266 0.9518
BB30-HNC GDSC1 6.6881 8.5554 3.707 0.6367
Ca9-22 GDSC1 6.7029 8.3985 3.7696 0.4311
SKN-3 GDSC1 6.7718 9.6255 3.3268 2.2868
NCI-H3118 GDSC1 6.7852 9.4678 3.3971 1.9024
OSC-20 GDSC1 6.7863 9.0267 3.5707 1.0885
SAS GDSC1 6.8181 8.5298 3.7663 0.3875
HSC-3 GDSC1 6.8218 8.3586 3.8274 0.2417
BICR 31 GDSC1 6.8333 8.8107 3.6709 0.6702
SCC-15 GDSC1 6.909 8.7226 3.732 0.4396
HO-1-u-1 GDSC1 6.9235 8.4732 3.8243 0.2178
PCI-38 GDSC1 6.9994 12.2748 2.2933 8.1608
LB771-HNC GDSC1 7.0275 9.0121 3.6735 0.5511
PCI-04B GDSC1 7.0934 8.9739 3.7121 0.4117
PCI-06A GDSC1 7.1181 9.1903 3.6442 0.5927
KOSC-2 GDSC1 7.1665 9.4177 3.5803 0.7733
BICR 78 GDSC1 7.2005 9.0871 3.7119 0.3692
JHU-022 GDSC1 7.2606 9.4705 3.5981 0.659
PE/CA-PJ15 GDSC1 7.3974 9.0058 3.8091 0.136
SAT [Human HNSCC] GDSC1 7.5813 10.2616 3.4349 1.0176
DOK GDSC1 7.7173 9.4689 3.7638 0.1398
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-29 GDSC1 5.45 7.5615 3.5177 3.235
BFTC-905 GDSC1 5.8971 7.3766 3.8235 0.7746
639V GDSC1 6.0072 7.0836 3.9746 0.1933
SW780 GDSC1 6.212 7.985 3.7248 0.9254
647V GDSC1 6.2892 7.8271 3.816 0.5111
HT-1197 GDSC1 6.3108 7.5165 3.9343 0.1805
KU-19-19 GDSC1 6.375 7.8527 3.8401 0.388
RT-112 GDSC1 6.5596 7.9882 3.8609 0.2561
SW1710 GDSC1 6.584 10.0122 3.0674 4.0831
RT-4 GDSC1 6.6069 8.5313 3.6832 0.7775
HT-1376 GDSC1 6.6716 8.7692 3.6203 0.9768
5637 GDSC1 6.6898 8.5381 3.714 0.6118
TCCSUP GDSC1 6.7257 8.4545 3.7583 0.4527
J82 GDSC1 6.7647 8.583 3.727 0.5267
T24 GDSC1 7.1216 8.9038 3.747 0.3163
UM-UC-3 GDSC1 7.941 15.3695 1.4435 11.1204
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC1 5.3669 8.2816 3.1306 6.1987
SiHa GDSC1 5.6659 6.8909 3.911 0.5989
HeLa GDSC1 5.9008 6.8488 4.0173 0.1371
SKG-IIIa GDSC1 6.0921 7.6682 3.7949 0.7297
JHOS-3 GDSC1 6.1309 8.6012 3.4354 2.5609
HEC-1 GDSC1 6.1636 7.8066 3.7724 0.7642
NCC-IT GDSC1 6.191 7.5881 3.8646 0.4097
SW756 GDSC1 6.2646 7.8683 3.791 0.6158
JEG-3 GDSC1 6.3346 8.0754 3.7421 0.7514
OVCA433 GDSC1 6.3468 8.3256 3.6514 1.1296
Ca Ski GDSC1 6.3893 9.2316 3.3006 2.972
C-4-I GDSC1 6.4259 7.9213 3.8349 0.3781
NEC8 GDSC1 6.4316 7.7335 3.9029 0.2076
LB831-BLC GDSC1 6.4492 8.695 3.5516 1.5017
DSH1 GDSC1 6.4645 8.3921 3.6765 0.9142
PEO1 GDSC1 6.4911 9.1327 3.3935 2.2867
JAR GDSC1 6.6681 8.4492 3.7379 0.5458
CAL-39 GDSC1 6.7088 8.9138 3.5809 1.1114
MS751 GDSC1 6.7415 8.3787 3.7911 0.3553
SKN GDSC1 6.7759 8.6044 3.7236 0.5313
KGN GDSC1 6.8002 9.0329 3.5742 1.0623
OVMIU GDSC1 6.809 11.1434 2.6931 6.0327
DoTc2 4510 GDSC1 6.8395 8.5413 3.7702 0.3682
OV17R GDSC1 6.8715 9.1477 3.5606 1.06
SW962 GDSC1 6.888 8.5213 3.795 0.2897
NT2-D1 GDSC1 6.9008 8.4893 3.8107 0.2517
ACC-OV7 GDSC1 6.9188 9.647 3.3868 1.8047
OMC-1 [Human cervical carcinoma] GDSC1 7.0262 8.917 3.7071 0.4546
HT-3 GDSC1 7.0305 8.7035 3.7834 0.2676
SW954 GDSC1 7.0606 8.8468 3.7446 0.344
OVCA420 GDSC1 7.0783 8.4642 3.8808 0.0991
C-33 A GDSC1 7.0858 8.768 3.781 0.2553
SiSo GDSC1 7.1231 8.865 3.7609 0.2853
ME-180 GDSC1 7.3648 9.5792 3.5991 0.6004
HEY GDSC1 7.4926 9.4218 3.7016 0.2926
UWB1.289 GDSC1 7.5396 18.1081 -0.1088 19.296
BPH-1 GDSC1 7.5529 9.7498 3.6093 0.484
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3539).
2 Clinical pipeline report, company report or official report of AstraZeneca (2009).
3 ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole. Breast Cancer Res Treat. 2010 Sep;123(2):345-57. doi: 10.1007/s10549-009-0644-2. Epub 2009 Nov 27.