Details of the Drug

General Information of Drug (ID: DMIWQ7G)

Drug Name
3-Methyl-1,2,3,4-tetrahydro-isoquinoline
Synonyms
3-Methyl-1,2,3,4-tetrahydroisoquinoline; 29726-60-1; 1,2,3,4-Tetrahydro-3-methylisoquinoline; Isoquinoline, 1,2,3,4-tetrahydro-3-methyl-; 3-Methyl-1,2,3,4-tetrahydro-isoquinoline; CHEMBL60434; UEKQPSAKUNXFHL-UHFFFAOYSA-N; BAS 03334621; AC1Q1HKS; AC1LC3M2; SCHEMBL1011182; SCHEMBL15334650; KS-00000JVD; MolPort-001-990-837; HMS1698C16; BDBM50023304; ANW-75096; AKOS016843414; AKOS000650337; AB30586; NE31770; MCULE-3517571472; NCGC00184271-01; DA-07231; KB-70931; BS-13528; TC-163841; ST24042290; FT-0729461; EN300-86328
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 147.22
Logarithm of the Partition Coefficient (xlogp) 1.8
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 1
Chemical Identifiers
Formula
C10H13N
IUPAC Name
3-methyl-1,2,3,4-tetrahydroisoquinoline
Canonical SMILES
CC1CC2=CC=CC=C2CN1
InChI
InChI=1S/C10H13N/c1-8-6-9-4-2-3-5-10(9)7-11-8/h2-5,8,11H,6-7H2,1H3
InChIKey
UEKQPSAKUNXFHL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
568974
TTD ID
D0Z7XI
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.