Details of the Drug

General Information of Drug (ID: DMJ0936)

• Drug Name: PF-03772304
• Synonyms: MTOR inhibitors, Biotica; MTOR inhibitors, Wyeth; PF-04979064; PF-05017255; PF-05168899; WYE-125132; WYE-132; WYE-178; WYE-354; WYE-600; WYE-687; Imidazolo and pyrazolopyrimidine derivatives (cancer), Pfizer; Imidazolopyrimidine derivatives (cancer), Pfizer; Imidazolopyrimidine derivatives (cancer), Wyeth; Non-rapamycin mTOR/PI3K inhibitors (cancer); PI3K/mTOR signalling inhibitors (cancer), Wyeth; Non-rapamycin mTOR/PI3K inhibitors (cancer), Pfizer; 5H-pyrrolo[3,2-d]pyridimine analogs (cancer), Wyeth

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

• Cross-matching ID: TTD ID: D05RSS

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Inhibitor	[1]
Serine/threonine-protein kinase mTOR (mTOR)	TTCJG29	MTOR_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Solid tumour/cancer
• ICD Disease Classification: 2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
PI3-kinase gamma (PIK3CG)	DTT	PIK3CG	1.98E-01	-0.05	-0.55

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RPMI-3460/CS1	GDSC1	0.9617	10.6926	-2.4586	41.5822
A-673	GDSC1	-9.7318	3.3925	-10.9371	81.3822
EW-13	GDSC1	-5.7811	2.6581	-6.434	77.559
SK-ES-1	GDSC1	-5.581	1.9366	-6.0495	78.8414
ES7	GDSC1	-5.0304	2.4345	-5.5621	76.3639
H-EMC-SS	GDSC1	-4.9814	6.404	-6.7255	68.9928
ES8	GDSC1	-4.8464	1.3605	-5.1403	78.6522
ES5	GDSC1	-4.6551	1.5549	-4.969	77.5989
EW-1	GDSC1	-4.5754	-1.2347	-4.5918	86.4969
NOS-1 [Human HNSCC]	GDSC1	-4.4494	2.0959	-4.8542	75.5706
EW-7	GDSC1	-4.4413	-0.6206	-4.4801	83.875
U2OS	GDSC1	-4.3699	4.4254	-5.39	70.3568
ES4	GDSC1	-4.3196	0.3049	-4.4265	80.3367
ES1	GDSC1	-4.3036	0.5389	-4.4359	79.5352
EW-22	GDSC1	-4.1858	3.4867	-4.9106	71.5532
EW-18	GDSC1	-4.0722	0.9017	-4.2362	77.6322
MG-63	GDSC1	-3.9946	7.4465	-6.0621	64.8966
CADO-ES1	GDSC1	-3.7873	0.9411	-3.9376	76.4274
MHH-ES-1	GDSC1	-3.7525	0.8217	-3.8852	76.642
EW-3	GDSC1	-3.4349	2.269	-3.7891	71.3691
SK-PN-DW	GDSC1	-3.2424	1.1264	-3.3814	73.3847
ES6	GDSC1	-2.9211	13.1883	-7.4297	57.522
HOS	GDSC1	-2.6717	5.0987	-3.7688	62.7227
EW-16	GDSC1	-2.4753	2.8049	-2.8662	65.2085
G-292 clone A141B1	GDSC1	-2.2396	12.6604	-6.5072	55.6941
CHSA8926	GDSC1	-2	14.3589	-7.0636	54.4358
CAL-72	GDSC1	-1.9868	5.6211	-3.2191	58.6658
HuO9	GDSC1	-1.82	6.92	-3.5488	56.7876
TC-71	GDSC1	-1.2765	3.6192	-1.7738	55.6365
HuO-3N1	GDSC1	-0.1132	16.2558	-6.1724	48.2616
CAL-78	GDSC1	-0.0754	11.0463	-3.6225	47.3323
NY	GDSC1	0.1925	10.7586	-3.2262	45.895
SJSA-1	GDSC1	0.3337	9.7584	-2.6149	44.7009
SaOS-2	GDSC1	1.3136	14.6059	-4.0501	42.2538
EW-24	GDSC1	5.5215	9.6828	1.7633	6.4401

Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JM1	GDSC1	-0.6899	11.8063	-4.5802	50.1943
A4/Fukuda	GDSC1	-6.8689	-0.182	-7.0734	86.35
PL-21	GDSC1	-6.8438	6.4684	-8.7574	72.915
L-363	GDSC1	-6.6205	2.1615	-7.2303	80.168
SIG-M5	GDSC1	-6.2701	0.1616	-6.4808	84.7481
OCI-M1	GDSC1	-6.118	-1.0589	-6.192	88.2799
HH [Human lymphoma]	GDSC1	-6.0875	8.1869	-8.579	69.2902
CTB-1	GDSC1	-6.0304	8.3868	-8.5955	68.9464
SUP-B15	GDSC1	-5.7068	-0.3443	-5.8231	85.5149
BC-1	GDSC1	-5.6316	3.9834	-6.6307	74.5106
SR	GDSC1	-5.5385	2.1968	-6.0606	78.1186
SU-DHL-16	GDSC1	-5.5158	-3.1581	-5.5164	95.0782
KE-37	GDSC1	-5.5121	-0.0634	-5.6472	84.3235
EM-2	GDSC1	-5.4407	5.0598	-6.7581	72.1655
GDM-1	GDSC1	-5.4135	3.5782	-6.276	74.8014
DoHH2	GDSC1	-5.3996	-1.9215	-5.4121	90.5281
MHH-PREB-1	GDSC1	-5.3478	2.0781	-5.8268	77.9879
SU-DHL-6	GDSC1	-5.3326	-2.5436	-5.3353	92.7469
MY-M12	GDSC1	-5.2628	2.6686	-5.8716	76.3915
Ramos.2G6.4C10	GDSC1	-5.1219	-1.7595	-5.1338	89.5713
OCI-AML-2	GDSC1	-5.1194	0.9358	-5.3628	80.5215
RCH-ACV	GDSC1	-5.1076	1.2587	-5.4041	79.5788
CA46	GDSC1	-5.0863	4.7648	-6.2773	71.7874
LAMA-84	GDSC1	-4.9979	1.2804	-5.2896	79.2566
THP-1	GDSC1	-4.9809	1.1265	-5.2449	79.6486
OPM-2	GDSC1	-4.9082	-2.5493	-4.9092	92.2549
QIMR-WIL	GDSC1	-4.849	4.5629	-5.9548	71.5088
TUR	GDSC1	-4.8164	2.7961	-5.4164	74.9581
CESS	GDSC1	-4.8152	1.1516	-5.0707	79.1598
RPMI-8226	GDSC1	-4.7668	4.4764	-5.8381	71.4348
CCRF-CEM	GDSC1	-4.7611	1.9196	-5.1556	76.9272
SU-DHL-5	GDSC1	-4.744	-3.0461	-4.7441	93.9107
MV4-11	GDSC1	-4.6859	1.3962	-4.9734	78.1219
BC-3	GDSC1	-4.6827	8.1357	-7.0644	66.09
Karpas-620	GDSC1	-4.682	-0.98	-4.7103	85.8165
MOLM-13	GDSC1	-4.6599	2.6205	-5.2026	74.9221
HAL-01	GDSC1	-4.6015	1.3043	-4.8664	78.1421
A3/Kawakami	GDSC1	-4.6009	0.0967	-4.7019	81.8447
Ku812	GDSC1	-4.5894	0.1611	-4.6963	81.6014
JSC-1	GDSC1	-4.5081	2.9407	-5.1166	73.7432
JURL-MK1	GDSC1	-4.4033	1.8661	-4.7566	76.0194
MOLP-8	GDSC1	-4.3685	0.3372	-4.4817	80.3844
PF-382	GDSC1	-4.3377	2.908	-4.9223	73.2858
697	GDSC1	-4.3359	-0.4388	-4.3817	82.9122
MOLT-16	GDSC1	-4.3321	0.7867	-4.4979	78.856
WIL2 NS	GDSC1	-4.2914	2.2647	-4.7191	74.6487
OCI-Ly19	GDSC1	-4.2171	3.6381	-4.9874	71.3512
RS4;11	GDSC1	-4.1394	4.2227	-5.0761	69.9817
NU-DUL-1	GDSC1	-4.132	0.6181	-4.2634	78.7143
Reh	GDSC1	-4.1255	0.5261	-4.2456	78.9809
NALM-6	GDSC1	-3.9892	1.3111	-4.2085	76.1331
H9	GDSC1	-3.9831	1.6802	-4.266	75.0904
NK-92MI	GDSC1	-3.9575	2.2579	-4.3547	73.5107
BV-173	GDSC1	-3.9413	0.5358	-4.0517	78.277
Karpas-231	GDSC1	-3.8509	0.3922	-3.9412	78.3781
ML-2	GDSC1	-3.8482	6.0922	-5.3925	66.0824
KCL-22	GDSC1	-3.8417	2.6081	-4.3082	72.2428
LP-1	GDSC1	-3.8057	7.2155	-5.7711	64.5621
ALL-PO	GDSC1	-3.7892	6.0536	-5.315	65.9349
SU-DHL-8	GDSC1	-3.7586	2.5064	-4.1939	72.159
HEL	GDSC1	-3.6031	1.7101	-3.8609	73.5033
MEG-01	GDSC1	-3.5739	1.9024	-3.8653	72.8801
KMS-12-BM	GDSC1	-3.5692	8.5107	-6.0404	62.487
P30/OHK	GDSC1	-3.5337	4.8413	-4.6152	66.7703
Loucy	GDSC1	-3.5102	4.9551	-4.6278	66.5037
ATN-1	GDSC1	-3.5002	17.7493	-10.1276	57.23
VAL	GDSC1	-3.4369	9.2478	-6.2099	61.4356
MC116	GDSC1	-3.4168	-1.4026	-3.4179	82.0003
RPMI-8402	GDSC1	-3.3955	1.4053	-3.5858	73.3825
GR-ST	GDSC1	-3.3617	6.0953	-4.8708	64.3541
GA-10	GDSC1	-3.2583	3.3201	-3.8526	68.3049
OCI-AML-5	GDSC1	-3.2512	4.825	-4.3033	65.6735
DEL	GDSC1	-3.2497	8.4892	-5.6963	61.4567
Karpas-422	GDSC1	-3.2436	15.905	-9.0093	57.2783
DB	GDSC1	-3.2317	9.7473	-6.21	60.4039
TK [Human B-cell lymphoma]	GDSC1	-3.2252	7.2871	-5.1822	62.4987
LC4-1	GDSC1	-3.1048	9.7992	-6.1012	59.959
ST486	GDSC1	-3.0998	3.5076	-3.7314	67.2235
SU-DHL-10	GDSC1	-3.0933	-1.3268	-3.0939	79.2578
Karpas-45	GDSC1	-3.0249	3.1398	-3.5498	67.5661
L-540	GDSC1	-2.9071	9.7376	-5.8705	59.3473
HC-1	GDSC1	-2.8482	16.6347	-8.9653	56.0819
JJN-3	GDSC1	-2.8078	1.6696	-2.9967	69.575
K-562	GDSC1	-2.7677	5.4525	-3.9975	62.719
SUP-HD1	GDSC1	-2.7622	4.853	-3.7823	63.4769
Jurkat	GDSC1	-2.709	4.2656	-3.5319	64.0648
KOPN-8	GDSC1	-2.7017	5.3269	-3.8814	62.5738
Daudi	GDSC1	-2.6704	11.4218	-6.3742	57.5957
KG-1	GDSC1	-2.6522	11.1845	-6.249	57.6566
Farage	GDSC1	-2.639	4.0786	-3.3972	63.9932
MN-60	GDSC1	-2.5958	4.3623	-3.4396	63.3513
P32/ISH	GDSC1	-2.5831	3.7228	-3.2293	64.2556
P12-Ichikawa	GDSC1	-2.4221	4.1343	-3.1783	62.7578
ALL-SIL	GDSC1	-2.3733	3.6245	-2.9719	63.234
MOLT-4	GDSC1	-2.3185	5.1789	-3.4154	60.8764
KMOE-2	GDSC1	-2.2522	4.3199	-3.0523	61.5588
EoL-1	GDSC1	-2.176	5.1389	-3.2474	60.1683
Raji	GDSC1	-2.1067	19.7037	-9.7212	53.6289
RPMI-6666	GDSC1	-1.9842	11.8825	-5.8941	55.1211
NOMO-1	GDSC1	-1.8866	24.0064	-11.6083	52.6091
RPMI-8866	GDSC1	-1.8472	11.1943	-5.4416	54.8699
Mono-Mac-6	GDSC1	-1.7838	4.779	-2.6974	58.2657
Sc-1	GDSC1	-1.7552	9.1868	-4.4461	55.2787
HL-60	GDSC1	-1.6166	8.0348	-3.8022	55.1658
CTV-1	GDSC1	-1.4199	7.3255	-3.2966	54.4906
AMO1	GDSC1	-1.3518	5.9428	-2.6631	54.7546
EJM	GDSC1	-1.3181	8.5915	-3.7363	53.5051
L-1236	GDSC1	-1.2964	11.3516	-4.9646	52.7225
NKM-1	GDSC1	-1.1426	16.1678	-7.0991	51.5489
KY821	GDSC1	-1.1189	5.9668	-2.425	53.2693
SU-DHL-4	GDSC1	-1.0877	6.102	-2.4455	53.0203
YT	GDSC1	-1.0811	23.5323	-10.6326	50.9656
SK-MM-2	GDSC1	-0.9517	10.5306	-4.2424	51.4043
SUP-T1	GDSC1	-0.9261	6.2285	-2.3255	51.929
L-428	GDSC1	-0.7923	4.5354	-1.5403	51.257
BALL-1	GDSC1	-0.7403	10.6439	-4.0852	50.4436
NB4	GDSC1	-0.7307	8.1532	-2.9419	50.4973
ME1	GDSC1	-0.6713	37.3759	-17.1165	50.0395
ROS-50	GDSC1	-0.6553	12.7361	-4.9873	50.0453
U266B1	GDSC1	-0.4377	5.3945	-1.4764	48.3582
HT	GDSC1	-0.3843	11.1994	-3.9956	48.8251
BE-13	GDSC1	-0.279	6.4298	-1.7295	47.3795
SKM-1	GDSC1	-0.2666	9.6167	-3.1391	48.0324
DND-41	GDSC1	-0.2536	4.8185	-1.061	46.5919
MOLT-13	GDSC1	-0.2122	11.0989	-3.7804	48.0041
U-698-M	GDSC1	-0.0559	9.8585	-3.0436	46.9437
BL-41	GDSC1	0.2436	4.5012	-0.4101	41.4648
VL51	GDSC1	0.3413	16.6049	-5.9225	46.7557
Karpas-299	GDSC1	0.4707	12.1872	-3.6462	45.0225
OCI-AML-3	GDSC1	0.5504	10.5744	-2.7936	43.8741
SUP-M2	GDSC1	0.7481	11.0848	-2.8505	43.0611
HDLM-2	GDSC1	0.7507	10.2102	-2.4269	42.4913
Jiyoye	GDSC1	1.0015	14.3992	-4.2325	43.5212
Granta-519	GDSC1	1.3416	24.1245	-8.7512	45.2855
Hs 445	GDSC1	1.4589	27.7015	-10.4316	45.6502
KMS-11	GDSC1	1.691	16.3171	-4.5595	41.565
WSU-NHL	GDSC1	1.8994	10.5948	-1.5389	35.5634
EHEB	GDSC1	2.1436	9.6544	-0.853	32.3674
SCC-3	GDSC1	2.4978	10.4738	-0.9411	31.1946
DG-75	GDSC1	2.7221	10.8297	-0.9213	30.2281
RL	GDSC1	2.7257	9.675	-0.3429	27.8691
MLMA	GDSC1	2.8884	6.2358	1.51	16.2121
RC-K8	GDSC1	3.0242	10.3964	-0.4442	27.1331
P31/FUJ	GDSC1	3.1683	12.182	-1.2142	29.6122
JVM-3	GDSC1	3.5038	10.0227	0.1451	22.4878
IM-9	GDSC1	3.6088	14.7403	-2.1268	30.9941
EB2	GDSC1	3.7631	16.9242	-3.0918	32.9468
WSU-DLCL2	GDSC1	3.9925	5.2619	2.8669	2.0723
ARH-77	GDSC1	4.2785	11.7235	-0.0859	21.0453
SU-DHL-1	GDSC1	4.5676	13.5109	-0.7504	23.2209
KM-H2	GDSC1	5.3634	17.1999	-1.9724	25.5278
JVM-2	GDSC1	5.4703	17.6114	-2.0954	25.6465

Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
ESO-26	GDSC1	-3.6163	9.6312	-6.5591	61.6805
OACP4 C	GDSC1	-3.1206	6.9087	-4.9223	62.5048
KYAE-1	GDSC1	-2.4903	6.6634	-4.1559	60.1675
OACM5.1 C	GDSC1	-2.2895	11.6114	-6.0759	56.2626
TE-12	GDSC1	-0.6132	17.9935	-7.4863	49.911
FLO-1	GDSC1	-0.4335	18.4376	-7.5364	49.3986
SK-GT-4	GDSC1	1.0179	20.1018	-7.0371	45.3131
HCE-4	GDSC1	1.5588	19.0271	-6.0234	43.2567
KYSE-220	GDSC1	2.259	17.1202	-4.4603	39.717
KYSE-50	GDSC1	4.0715	21.897	-5.3251	36.123

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	GDSC1	-6.6921	9.3763	-9.6874	69.1692

Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NB1	GDSC1	-7.8667	15.7919	-13.6137	66.0036
GI-ME-N	GDSC1	-5.6441	20.9921	-13.7519	60.0805
SK-N-BE(2)-M17	GDSC1	-5.408	16.8557	-11.5984	61.4026
KP-N-YS	GDSC1	-5.3186	9.5199	-8.2938	66.2256
GOTO	GDSC1	-4.074	5.0387	-5.2673	68.375
SJNB-14	GDSC1	-4.0493	4.0372	-4.9214	70.0193
Kelly	GDSC1	-3.2081	6.7131	-4.9396	63.047
SiMa	GDSC1	-3.1288	7.6566	-5.2281	61.7855
SK-N-MC-IXC	GDSC1	-2.187	7.5468	-4.1918	58.0943
SJNB-7	GDSC1	-2.0031	4.0477	-2.6951	60.417
CHP-134	GDSC1	-1.7124	5.9365	-3.0448	56.888
SJNB-12	GDSC1	-1.3946	16.6121	-7.5531	52.2442
LA-N-6	GDSC1	-1.0014	8.8713	-3.5372	51.8668
NB(TU)1	GDSC1	-0.684	13.3981	-5.3307	50.1519
NB69	GDSC1	-0.6376	35.2931	-16.0516	49.9905
SJNB-17	GDSC1	-0.5373	16.7352	-6.8023	49.6682
IMR-5	GDSC1	-0.5364	20.9071	-8.8425	49.7286
KP-N-YN	GDSC1	-0.2109	9.2669	-2.9219	47.6578
SK-N-FI	GDSC1	0.166	45.5236	-20.4417	49.0225
MHH-NB-11	GDSC1	0.4896	11.3446	-3.2216	44.5788
NH-12	GDSC1	0.5946	31.0241	-12.8416	47.7812
SJNB-13	GDSC1	1.9765	10.2468	-1.2971	34.5437
CHP-212	GDSC1	2.2445	5.7805	1.1271	21.791
TGW	GDSC1	2.8989	7.0408	1.1201	18.9366
SJNB-6	GDSC1	3.7703	8.3263	1.2072	15.062
SJNB-10	GDSC1	3.8763	8.4852	1.2112	14.6764
SK-N-DZ	GDSC1	4.1895	14.6945	-1.6343	27.6952
SK-N-AS	GDSC1	4.4014	9.5659	1.0735	13.9328
SJNB-5	GDSC1	6.1267	26.3847	-5.9385	32.662
SK-N-SH	GDSC1	7.0053	17.9036	-1.1472	18.6165

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuCC-T1	GDSC1	-2.3221	4.2934	-3.1198	61.9865

Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HCC1500	GDSC1	-8.7776	4.3933	-10.1829	78.8272
EFM-19	GDSC1	-6.0355	9.6106	-9.0863	67.6707
MRK-nu-1	GDSC1	-5.8488	-4.0053	-5.8489	97.7624
MDA-MB-361	GDSC1	-5.745	10.8801	-9.3045	65.9133
HCC1599	GDSC1	-5.279	-1.0031	-5.3245	87.0721
MDA-MB-453	GDSC1	-5.2528	6.3872	-7.0117	69.6983
Hs 578T	GDSC1	-5.1723	5.0479	-6.4627	71.5297
ZR-75-30	GDSC1	-5.1455	19.7881	-12.6976	59.693
UACC-893	GDSC1	-5.0823	5.0434	-6.3634	71.308
OCUB-M	GDSC1	-4.9652	-2.4203	-4.967	91.8452
CAMA-1	GDSC1	-4.8678	8.1577	-7.2695	66.5437
HCC1419	GDSC1	-4.7298	9.4916	-7.6634	64.8512
MDA-MB-330	GDSC1	-4.375	18.9139	-11.5314	58.6119
HCC1187	GDSC1	-4.3342	6.4005	-6.0281	67.2033
BT-474	GDSC1	-4.3235	7.7749	-6.5407	65.5039
BT-483	GDSC1	-4.2913	20.9489	-12.4123	57.7953
MDA-MB-468	GDSC1	-4.1735	3.6656	-4.9477	71.1523
T-47D	GDSC1	-3.9492	26.1306	-14.5737	55.9652
DU4475	GDSC1	-3.6759	1.3556	-3.8791	74.7729
CAL-148	GDSC1	-3.5936	1.1888	-3.7653	74.8875
MFM-223	GDSC1	-3.0166	5.9401	-4.4428	63.1917
Evsa-T	GDSC1	-2.6183	22.2105	-11.4181	54.3125
HCC2157	GDSC1	-2.5913	8.291	-4.9249	59.2272
BT-549	GDSC1	-2.2914	7.8752	-4.4375	58.3128
CAL-120	GDSC1	-2.2654	10.2171	-5.4234	56.8139
HCC1954	GDSC1	-2.1475	7.1003	-3.9673	58.2441
HCC1569	GDSC1	-2.0455	9.7751	-5.0029	56.1986
YMB-1-E	GDSC1	-1.8399	24.3736	-11.7447	52.481
MDA-MB-175-VII	GDSC1	-1.8024	15.228	-7.2826	53.6498
HCC202	GDSC1	-1.7906	14.3036	-6.833	53.8121
AU565	GDSC1	-1.7703	9.9368	-4.7949	55.0342
CAL-51	GDSC1	-1.6199	20.763	-9.7766	52.3633
HCC1428	GDSC1	-1.0775	18.2229	-8.0325	51.2131
MDA-MB-415	GDSC1	-0.9814	31.6605	-14.5556	50.5646
COLO 824	GDSC1	-0.6393	6.3826	-2.0867	49.9682
MCF-7	GDSC1	-0.4293	6.4736	-1.9048	48.4919
HCC38	GDSC1	-0.191	9.0231	-2.7897	47.4898
HCC70	GDSC1	-0.1375	14.3792	-5.2822	48.1411
CAL-85-1	GDSC1	-0.0696	15.2375	-5.6353	47.9952
EFM-192A	GDSC1	0.5719	15.6656	-5.2492	45.7068
MDA-MB-231	GDSC1	0.8346	19.579	-6.9419	45.7551
MDA-MB-157	GDSC1	1.2799	12.1734	-2.8833	40.8908
HCC1806	GDSC1	1.7495	12.9412	-2.8333	38.9955
HDQ-P1	GDSC1	1.8621	11.737	-2.1364	37.1865
MDA-MB-436	GDSC1	1.9966	29.2448	-10.7378	44.7419
HCC2218	GDSC1	2.0759	34.1711	-13.1308	45.3872
HCC1937	GDSC1	2.3202	13.6687	-2.687	36.6453
UACC-812	GDSC1	2.6633	13.1014	-2.1053	34.0956
HCC1395	GDSC1	3.4067	16.482	-3.1647	34.1416
BT-20	GDSC1	3.4884	14.9919	-2.3519	31.9821

Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
D283 Med	GDSC1	-5.9286	4.8054	-7.2065	73.683
AM-38	GDSC1	-3.7529	7.7298	-5.9175	63.8342
YH-13	GDSC1	-3.5392	12.196	-7.6023	59.7302
GI-1	GDSC1	-2.8703	2.6509	-3.2601	67.758
MOG-G-CCM	GDSC1	-2.5721	8.3082	-4.9121	59.1396
PFSK-1	GDSC1	-2.481	15.085	-7.876	55.6048
YKG-1	GDSC1	-2.2281	3.7939	-2.8631	62.1284
GB-1	GDSC1	-1.6321	6.5373	-3.1958	56.0433
ONS-76	GDSC1	-1.5389	5.1319	-2.5579	56.4303
DK-MG	GDSC1	-1.5045	11.8176	-5.3871	53.4202
KS-1 [Human Krukenberg tumour]	GDSC1	-1.2614	7.4856	-3.1991	53.5761
U-118MG	GDSC1	-1.1174	20.6583	-9.2571	51.1783
SNB-75	GDSC1	-1.0464	11.8724	-4.9605	51.6479
D-263MG	GDSC1	-0.9259	8.433	-3.2652	51.5431
GaMG	GDSC1	-0.8543	11.5908	-4.6398	50.8919
SW1783	GDSC1	-0.6267	12.5824	-4.8865	49.9312
D-542MG	GDSC1	-0.6089	10.0247	-3.6678	49.8293
8-MG-BA	GDSC1	-0.5756	6.9009	-2.2377	49.5495
D-336MG	GDSC1	-0.4379	10.9996	-3.9539	49.0567
NMC-G1	GDSC1	-0.3558	5.6973	-1.5089	47.7664
D-423MG	GDSC1	-0.2591	11.007	-3.7827	48.2146
CAS-1	GDSC1	-0.1489	14.1596	-5.1866	48.1581
KINGS-1	GDSC1	-0.1189	11.724	-3.987	47.6727
M059J	GDSC1	0.1501	10.5208	-3.1544	46.0375
SF126	GDSC1	0.153	20.7518	-8.1368	47.9079
LN-405	GDSC1	0.3343	16.916	-6.0817	46.8376
U-251MG	GDSC1	0.4409	8.0707	-1.7212	42.9947
SW1088	GDSC1	0.4633	17.5478	-6.2744	46.5221
D-566MG	GDSC1	0.6744	8.886	-1.8707	41.9999
KALS-1	GDSC1	0.6919	7.7452	-1.3211	40.8543
SF539	GDSC1	0.7793	14.1326	-4.3059	44.3713
Daoy	GDSC1	0.9339	16.1739	-5.1686	44.4876
Onda 11	GDSC1	1.1438	13.1486	-3.4872	42.2278
D-392MG	GDSC1	1.1987	15.0959	-4.3962	42.9953
Becker	GDSC1	1.2164	14.3036	-3.9892	42.5271
KNS-81-FD	GDSC1	1.2343	18.5325	-6.0656	44.187
D-247MG	GDSC1	1.274	12.7421	-3.1679	41.3231
MOG-G-UVW	GDSC1	1.3264	15.3228	-4.3928	42.5658
42-MG-BA	GDSC1	1.3641	19.4606	-6.411	44.05
SF295	GDSC1	1.3754	9.6814	-1.5781	37.9849
LN-229	GDSC1	1.443	10.871	-2.0945	38.8298
D-502MG	GDSC1	1.4958	11.753	-2.4781	39.3501
LNZTA3WT4	GDSC1	1.5918	11.7854	-2.4061	38.8276
SF268	GDSC1	2.4052	16.2748	-3.9119	38.5148
LN-18	GDSC1	2.8067	13.9628	-2.4117	34.3534
Hs 683	GDSC1	3.1016	12.8623	-1.6106	31.1529
U-87MG ATCC	GDSC1	3.3765	26.2513	-8.0745	40.5753
DBTRG-05MG	GDSC1	3.4832	14.0948	-1.9076	30.7649
Onda 10	GDSC1	3.7611	17.7568	-3.5096	33.8395
SK-MG-1	GDSC1	4.3069	21.3554	-4.864	34.871
H4	GDSC1	4.6547	25.2022	-6.5045	36.3935
T98G	GDSC1	5.8075	13.4997	0.1532	15.4841
A-172	GDSC1	8.1332	28.871	-5.6723	28.5537
KNS-42	GDSC1	9.331	34.9986	-7.8042	30.0253

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
ETK-1	GDSC1	-2.818	5.0043	-3.8945	63.5296
TGBC24TKB	GDSC1	0.2263	9.3133	-2.5108	45.1292
TGBC1TKB	GDSC1	3.0507	15.6299	-3.0371	34.9542

Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
AN3-CA	GDSC1	-8.352	14.3021	-13.4681	67.6728
RL95-2	GDSC1	-6.6295	16.0812	-12.4793	63.9263
MFE-280	GDSC1	-3.2337	15.7829	-8.9424	57.2989
MFE-296	GDSC1	-2.6632	33.5887	-17.0291	53.0411
MFE-319	GDSC1	-2.0334	4.361	-2.8278	60.2302
EN	GDSC1	-1.1315	23.5164	-10.671	51.0752
ESS-1	GDSC1	0.3023	10.4577	-2.9769	45.1932
KLE	GDSC1	4.3562	31.8358	-10.0591	40.2161

Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SW156	GDSC1	-6.9262	-1.6083	-6.9944	90.4786
VMRC-RCZ	GDSC1	-3.6765	9.0013	-6.3563	62.385
769-P	GDSC1	-3.5375	7.3626	-5.5435	63.5141
KTCTL-140	GDSC1	-3.1524	6.3502	-4.7416	63.2469
KTCTL-21	GDSC1	-3.123	17.0955	-9.4509	56.5933
CAL-54	GDSC1	-2.9757	9.495	-5.8366	59.7449
HA7-RCC	GDSC1	-2.8741	9.1958	-5.603	59.6084
SW13	GDSC1	-2.6229	9.3311	-5.4012	58.6221
KTCTL-26A	GDSC1	-2.3038	13.62	-7.0159	55.5625
UO-31	GDSC1	-2.0984	24.0465	-11.8246	53.0238
786-O	GDSC1	-2.0403	7.3115	-3.9407	57.5925
ACHN	GDSC1	-1.9685	12.4055	-6.1198	54.8948
LB2241-RCC	GDSC1	-1.374	9.2373	-4.0795	53.5716
NCC021	GDSC1	-1.3077	13.923	-6.1833	52.3283
KTCTL-195	GDSC1	-0.556	14.2197	-5.6022	49.6828
TK-10	GDSC1	-0.4748	7.2661	-2.2903	48.9146
SN12C	GDSC1	-0.445	19.8433	-8.2359	49.4698
LB1047-RCC	GDSC1	-0.1502	9.0524	-2.7625	47.2611
KTCTL-13	GDSC1	-0.1497	18.3901	-7.2508	48.563
BB65-RCC	GDSC1	-0.0711	14.5227	-5.2893	47.9083
KTCTL-1M	GDSC1	0.2887	17.861	-6.5882	47.1471
Caki-1	GDSC1	0.5588	19.489	-7.1457	46.5769
OS-RC-2	GDSC1	1.1844	21.9121	-7.7885	45.2403
KMRC-1	GDSC1	1.5129	16.5118	-4.8146	42.3779
BFTC-909	GDSC1	3.1984	11.2447	-0.7204	27.6415
KMRC-20	GDSC1	3.4287	21.2934	-5.552	37.9604
LB996-RCC	GDSC1	3.5466	22.1518	-5.8834	38.0824
RCC10RGB	GDSC1	3.7028	26.2892	-7.8228	39.7076
A-704	GDSC1	5.0675	20.1465	-3.6589	30.7762
A-498	GDSC1	5.131	6.6382	2.8553	0.6219
VMRC-RCW	GDSC1	5.382	19.5662	-3.1287	28.772
RXF 393L	GDSC1	6.2818	18.4287	-1.9029	23.0365

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SNU-81	GDSC1	-3.0808	55.9175	-28.4643	52.2632
RKO	GDSC1	-2.6437	7.7076	-4.7377	59.8933
LoVo	GDSC1	-1.8214	14.7412	-7.0701	53.8092
CCK-81	GDSC1	-0.2651	15.9133	-6.1472	48.7448
LS513	GDSC1	-0.0173	8.1533	-2.2181	46.1587
SNU-175	GDSC1	0.0698	24.4426	-10.0371	48.4093
SW837	GDSC1	0.0941	7.8206	-1.9551	45.2672
NCI-H747	GDSC1	0.4477	21.6589	-8.3193	47.2158
SNU-C1	GDSC1	0.4997	27.5049	-11.1741	47.6958
HCT 15	GDSC1	0.5861	11.4841	-3.197	44.1418
SNU-C2B	GDSC1	1.2357	18.4558	-6.0263	44.1576
LS411N	GDSC1	1.2532	17.5052	-5.5392	43.7716
COLO205	GDSC1	1.463	24.0928	-8.6293	44.9662
CaR-1	GDSC1	1.6625	18.1803	-5.5107	42.5603
HT115	GDSC1	1.9844	17.6519	-4.9648	41.1126
HCT 116	GDSC1	2.0175	14.2754	-3.2557	38.7478
SNU-1040	GDSC1	2.3295	17.4884	-4.5827	39.6643
KM12	GDSC1	2.648	17.0074	-4.0683	38.0167
HT-55	GDSC1	2.6835	24.433	-7.7479	41.7832
SW1116	GDSC1	2.9365	14.4068	-2.5226	34.1813
LS180	GDSC1	3.1031	21.1963	-5.7757	39.0211
C2BBe1	GDSC1	3.1716	19.5904	-4.9153	37.778
COLO 320HSR	GDSC1	3.1955	15.7437	-2.972	34.3679
SW948	GDSC1	3.2811	14.5608	-2.3089	32.5285
SNU-407	GDSC1	3.797	19.2251	-4.214	35.0602
RCM-1 [Human ESC]	GDSC1	4.1688	16.7088	-2.6556	30.746
SW1417	GDSC1	4.8344	17.216	-2.3837	28.1736
SW626	GDSC1	4.9824	21.0476	-4.1735	32.0455
SW620	GDSC1	5.0096	17.7488	-2.513	28.0774
CL-11	GDSC1	5.0568	18.4191	-2.8093	28.7613
SW1463	GDSC1	5.3947	13.7854	-0.2726	18.7001
LS123	GDSC1	5.4933	11.6562	0.8236	12.4984
HT-29	GDSC1	5.6585	28.2188	-7.2124	35.2883
T84	GDSC1	5.6821	14.9188	-0.6201	19.5484
COLO 678	GDSC1	5.7005	11.036	1.2498	9.3685
SNU-61	GDSC1	5.8909	18.8999	-2.4178	25.5986
NCI-H716	GDSC1	5.953	17.4906	-1.6811	23.0617
GP5d	GDSC1	5.9559	26.6273	-6.1902	33.3695
LS1034	GDSC1	6.3367	19.2629	-2.2708	24.1031
HCC2998	GDSC1	6.3377	18.6668	-1.9791	23.161
SNU-C5	GDSC1	6.3442	20.5659	-2.9033	25.937
CW-2	GDSC1	6.7599	18.418	-1.5614	20.74
SW48	GDSC1	6.897	21.7609	-3.0882	25.2362
MDST8	GDSC1	7.0333	27.3317	-5.7222	30.5989

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MO-T	GDSC1	0.5047	12.3239	-3.6803	44.9121

Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JHH-2	GDSC1	-10.2585	6.8906	-12.5979	77.0009
JHH-4	GDSC1	-9.4696	1.4983	-10.1809	84.493
SNU-423	GDSC1	-8.1217	1.0104	-8.6163	84.4887
Hep 3B2.1-7	GDSC1	-7.5843	4.8572	-9.0247	76.5314
SNU-398	GDSC1	-7.2487	7.7409	-9.6534	71.9735
JHH-1	GDSC1	-6.0439	30.4948	-18.6679	58.0101
Huh-7	GDSC1	-5.7732	8.2898	-8.284	68.5139
SNU-387	GDSC1	-5.3379	19.935	-12.9556	59.967
SNU-475	GDSC1	-3.7413	5.8894	-5.2039	65.9923
SNU-449	GDSC1	-1.7598	6.9833	-3.5112	56.4418
HLE	GDSC1	0.8068	30.4342	-12.3619	47.3324
Hep-G2/C3A	GDSC1	1.0486	13.8685	-3.9284	43.0628
JHH-6	GDSC1	1.3082	149.8334	-71.5961	49.2783
JHH-7	GDSC1	2.8563	26.077	-8.4235	41.8889
HuH-1	GDSC1	4.5112	5.8095	2.9062	0.9781
SK-HEP-1	GDSC1	7.4349	37.3012	-10.3485	35.6586

Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H1581	GDSC1	-4.884	10.9079	-8.4197	64.0048
IST-SL2	GDSC1	-4.7391	10.1118	-7.9317	64.3202
BEN	GDSC1	-4.4016	16.7411	-10.5428	59.5093
LCLC-97TM1	GDSC1	-4.2047	15.7723	-9.8991	59.5205
NCI-H1648	GDSC1	-4.1834	5.8512	-5.6667	67.5005
HCC78	GDSC1	-3.7511	5.1272	-4.9471	67.1292
NCI-H1048	GDSC1	-3.7421	1.3154	-3.9438	75.1604
UMC-11	GDSC1	-3.6123	2.9762	-4.1484	70.5207
NCI-H211	GDSC1	-3.3895	10.476	-6.6886	60.3792
NCI-H69	GDSC1	-3.2667	5.3714	-4.5073	64.9432
NCI-H1876	GDSC1	-3.2656	2.082	-3.5666	71.0346
SBC-1	GDSC1	-3.0827	4.975	-4.1712	64.7439
Lu-139	GDSC1	-2.9137	6.9312	-4.7111	61.6802
Lu-99A	GDSC1	-2.6858	12.4532	-6.8576	57.1596
SBC-3	GDSC1	-2.66	2.2778	-2.9496	67.3461
NCI-H1793	GDSC1	-2.5874	27.6157	-14.0242	53.5043
DMS 114	GDSC1	-2.5839	8.0355	-4.8104	59.3924
NCI-H209	GDSC1	-2.378	3.968	-3.0789	62.7511
COR-L303	GDSC1	-2.2205	3.848	-2.871	62.0071
NCI-H2869	GDSC1	-2.1795	6.0261	-3.578	59.2989
NCI-H64	GDSC1	-2.0807	4.7937	-3.0239	60.0165
NCI-H524	GDSC1	-2.08	6.1379	-3.5145	58.6969
RERF-LC-Sq1	GDSC1	-2.0588	15.413	-7.6191	54.3464
NCI-H2803	GDSC1	-1.9581	7.8796	-4.0912	56.8457
NCI-H520	GDSC1	-1.7038	6.391	-3.2135	56.5267
CAL-12T	GDSC1	-1.6971	6.4135	-3.2152	56.4752
DMS 273	GDSC1	-1.6965	12.5731	-5.9284	53.9209
Calu-3	GDSC1	-1.6923	8.2011	-3.952	55.4459
HOP-62	GDSC1	-1.6365	3.1251	-2.0312	58.9502
NCI-H526	GDSC1	-1.5564	2.9139	-1.8911	58.543
NCI-H2818	GDSC1	-1.5454	8.3873	-3.8806	54.6711
NCI-H727	GDSC1	-1.4853	11.449	-5.1974	53.437
NCI-H847	GDSC1	-1.4809	7.0985	-3.2657	54.9205
NCI-H1623	GDSC1	-1.4476	8.14	-3.6726	54.2976
NCI-H1781	GDSC1	-1.43	9.2936	-4.1615	53.8087
NCI-H446	GDSC1	-1.3964	4.3437	-2.1302	56.0369
NCI-H2444	GDSC1	-1.3616	6.6074	-2.9385	54.4892
SBC-5	GDSC1	-1.3064	4.0196	-1.9277	55.5945
NCI-H2347	GDSC1	-1.2658	12.8174	-5.6196	52.3483
NCI-H2087	GDSC1	-0.9941	15.9668	-6.8611	51.1096
NCI-H720	GDSC1	-0.9829	4.8093	-1.8428	52.7118
EPLC-272H	GDSC1	-0.7696	14.3153	-5.8522	50.4455
NCI-H2795	GDSC1	-0.6786	31.6469	-14.2779	50.0586
RERF-LC-MS	GDSC1	-0.6697	4.7306	-1.4768	50.2167
NCI-H2722	GDSC1	-0.5201	14.4975	-5.7018	49.5597
NCI-H2373	GDSC1	-0.4867	43.8092	-20.1558	49.8057
NCI-H3255	GDSC1	-0.4815	11.1549	-4.0697	49.2682
Lu-135	GDSC1	-0.4343	8.6341	-2.8564	48.8219
NCI-H661	GDSC1	-0.416	14.6774	-5.6899	49.1934
NCI-H1770	GDSC1	-0.3923	12.96	-4.8408	49.0012
ABC-1	GDSC1	-0.3603	11.1089	-3.9296	48.7052
NCI-H2135	GDSC1	-0.3075	15.041	-5.7634	48.8283
NCI-H358	GDSC1	-0.261	8.2953	-2.5282	47.7389
PaCa-3	GDSC1	-0.2414	11.2576	-3.8839	48.1666
LK-2	GDSC1	-0.2356	14.511	-5.4387	48.5232
NCI-H1155	GDSC1	-0.2255	10.5898	-3.5532	47.986
NCI-H1568	GDSC1	-0.2144	10.977	-3.7249	47.9951
Ms-1	GDSC1	-0.1724	7.6321	-2.1411	46.9962
LB647-SCLC	GDSC1	-0.1585	7.2728	-1.968	46.783
NCI-H1666	GDSC1	-0.1238	15.2324	-5.6836	48.1898
COR-L105	GDSC1	-0.0591	19.6609	-7.7922	48.3982
COLO 668	GDSC1	-0.0508	9.8012	-3.0117	46.9
NCI-H650	GDSC1	-0.048	49.7574	-22.739	49.3445
NCI-H1792	GDSC1	-0.0223	7.3818	-1.8768	45.8715
COR-L23	GDSC1	-0.0146	10.7491	-3.4226	46.9594
CPC-N	GDSC1	0.0168	12.6244	-4.2883	47.2355
NCI-H226	GDSC1	0.0464	6.8484	-1.5718	45.1039
NCI-H2291	GDSC1	0.1256	93.2557	-44.3133	49.5465
NCI-H187	GDSC1	0.1383	8.7248	-2.3242	45.4038
EKVX	GDSC1	0.1608	11.4473	-3.5855	46.277
LC-2/ad	GDSC1	0.2305	11.8743	-3.7236	46.0683
NCI-H2196	GDSC1	0.2475	9.8765	-2.7547	45.2543
COR-L321	GDSC1	0.2796	12.385	-3.9229	45.9928
NCI-H2081	GDSC1	0.3947	6.769	-1.1797	42.2951
NCI-H2810	GDSC1	0.4287	8.7875	-2.0658	43.5694
NCI-H1734	GDSC1	0.4349	13.1473	-4.1455	45.5273
EMC-BAC-2	GDSC1	0.4479	24.5815	-9.7679	47.5441
NCI-H1694	GDSC1	0.4871	7.3062	-1.3259	42.0315
COR-L311	GDSC1	0.4986	10.162	-2.6464	43.9474
NCI-H2171	GDSC1	0.5884	13.0409	-3.9499	44.7974
PC-14	GDSC1	0.593	10.9906	-2.9526	43.858
NCI-H2591	GDSC1	0.638	12.8539	-3.8125	44.494
NCI-H146	GDSC1	0.677	13.2277	-3.9582	44.4662
NCI-H2141	GDSC1	0.7075	12.4683	-3.5596	43.9943
Calu-6	GDSC1	0.7364	20.4572	-7.465	46.2248
NCI-H2731	GDSC1	0.8224	11.6712	-3.0643	43.0007
NCI-H82	GDSC1	0.8494	8.8452	-1.6808	40.7603
NCI-H810	GDSC1	0.9119	8.4091	-1.4138	39.8756
NCI-H1975	GDSC1	0.9139	12.0178	-3.1471	42.7217
NCI-H1993	GDSC1	1.0796	19.6171	-6.7416	45.003
NCI-H3122	GDSC1	1.0864	24.832	-9.3274	46.0507
NCI-H596	GDSC1	1.1199	19.026	-6.4124	44.7147
NCI-H835	GDSC1	1.1349	14.428	-4.1248	42.9517
NCI-H1915	GDSC1	1.1987	12.9101	-3.3196	41.8128
NCI-H647	GDSC1	1.2134	8.8393	-1.3263	38.1363
NCI-H292	GDSC1	1.2295	19.5654	-6.5825	44.5146
HCC827	GDSC1	1.2629	15.0846	-4.3324	42.7178
NCI-H1573	GDSC1	1.369	10.5699	-2.0162	38.9902
NCI-H290	GDSC1	1.3806	15.2708	-4.3182	42.3103
NCI-H1688	GDSC1	1.4194	12.1224	-2.7299	40.0941
EMC-BAC-1	GDSC1	1.4499	15.3878	-4.3138	42.0763
NCI-H1304	GDSC1	1.4616	6.5226	0.0092	32.2032
NCI-H1869	GDSC1	1.5659	19.4289	-6.217	43.3771
NCI-H2110	GDSC1	1.6463	13.6389	-3.2715	40.0831
NCI-H1105	GDSC1	1.6566	13.7056	-3.2952	40.0814
NCI-H2029	GDSC1	1.853	10.5947	-1.5812	35.8741
NCI-H1836	GDSC1	1.9587	12.6986	-2.5253	37.6328
COR-L88	GDSC1	1.9589	9.941	-1.1626	34.2087
NCI-H1703	GDSC1	2.005	16.5719	-4.409	40.4201
NCI-H2228	GDSC1	2.101	12.1318	-2.1171	36.2064
LXF 289	GDSC1	2.1171	12.1206	-2.0972	36.0974
Lu-134-A	GDSC1	2.2429	9.1944	-0.5358	30.7304
Lu-165	GDSC1	2.375	10.2912	-0.9595	31.7633
IST-SL1	GDSC1	2.5556	14.2974	-2.7951	36.0561
NCI-H2342	GDSC1	2.6404	17.3991	-4.2703	38.3373
NCI-H322M	GDSC1	2.6528	13.6761	-2.401	34.8555
NCI-H2461	GDSC1	2.7049	19.9523	-5.4907	39.7057
COR-L95	GDSC1	2.795	9.4316	-0.161	26.7534
NCI-H1341	GDSC1	2.8747	11.7232	-1.2351	30.7551
NCI-H1755	GDSC1	2.9006	13.5274	-2.1139	33.2872
Lu-65	GDSC1	2.9268	22.2948	-6.4733	40.1707
NCI-H1435	GDSC1	2.9329	20.6951	-5.6685	39.3225
NCI-H510A	GDSC1	3.01	19.2134	-4.8627	38.1331
DMS 53	GDSC1	3.1029	12.098	-1.2275	29.8931
NCI-H2066	GDSC1	3.144	15.3365	-2.8117	34.1758
LCLC-103H	GDSC1	3.3086	26.4403	-8.2256	40.8292
NCI-H23	GDSC1	3.3921	13.9516	-1.9117	31.074
NCI-H2804	GDSC1	3.3934	15.5788	-2.7241	33.2004
NCI-H2405	GDSC1	3.4283	26.0752	-7.9433	40.3654
IA-LM	GDSC1	3.4417	20.2495	-5.0193	37.2265
NCI-H2369	GDSC1	3.4654	15.4822	-2.616	32.7203
EBC-1	GDSC1	3.4697	20.8423	-5.2925	37.5269
NCI-H1944	GDSC1	3.5399	15.1535	-2.3901	31.921
NCI-H1436	GDSC1	3.5452	13.9578	-1.788	30.2047
SW1271	GDSC1	3.6301	25.0254	-7.251	39.3423
NCI-H522	GDSC1	3.6486	26.9301	-8.188	40.121
HCC33	GDSC1	3.6969	12.9127	-1.1412	27.5278
NCI-H2009	GDSC1	3.718	20.3021	-4.8172	36.2371
NCI-H1563	GDSC1	4.0317	23.5485	-6.1828	37.3356
NCI-H2595	GDSC1	4.2146	17.0574	-2.7929	30.9651
NCI-H513	GDSC1	4.2503	15.9873	-2.2306	29.3582
RERF-LC-KJ	GDSC1	4.2666	19.1197	-3.7804	33.0323
A-427	GDSC1	4.3648	20.8167	-4.5484	34.2091
SHP-77	GDSC1	4.4306	11.7071	0.0388	19.9309
NCI-H1092	GDSC1	4.6919	17.7095	-2.74	29.5299
HARA [Human squamous cell lung carcinoma]	GDSC1	4.7498	21.2252	-4.4451	33.1062
NCI-H2030	GDSC1	4.8923	17.3942	-2.4273	28.1439
NCI-H2023	GDSC1	5.0085	12.0454	0.2997	16.8205
NCI-H1651	GDSC1	5.0233	16.032	-1.6517	25.3614
NCI-H2122	GDSC1	5.2062	9.6403	1.5896	8.2934
SW1573	GDSC1	5.2464	25.6729	-6.2687	34.8805
NCI-H1650	GDSC1	5.3161	17.5366	-2.1742	26.2863
NCI-H345	GDSC1	5.4046	18.1174	-2.3946	26.7242
NCI-H1299	GDSC1	5.7516	10.772	1.4034	8.2817
NCI-H838	GDSC1	5.8073	7.0895	2.9473	0.1085
KNS-62	GDSC1	5.9418	14.5231	-0.2471	17.1625
SK-MES-1	GDSC1	5.9834	8.086	2.6626	0.7443
HCC15	GDSC1	5.9948	16.6208	-1.2265	21.2788
SK-LU-1	GDSC1	6.0155	21.8013	-3.7548	28.7996
NCI-H2172	GDSC1	6.0835	7.4465	2.9224	0.0949
NCI-H1437	GDSC1	6.0877	14.2445	-0.0143	15.6566
LOU-NH91	GDSC1	6.0912	22.4903	-4.0382	29.263
NCI-H1355	GDSC1	6.1144	26.5297	-6.0198	32.8101
NCI-H841	GDSC1	7.0418	25.917	-5.0195	29.3221
NCI-H1838	GDSC1	7.1143	22.4526	-3.2702	25.266
NCI-H2170	GDSC1	7.2127	19.3847	-1.7165	20.307
A-549	GDSC1	7.2721	21.1193	-2.5115	22.796
NCI-H460	GDSC1	7.5185	17.2216	-0.4909	14.7565
NCI-H196	GDSC1	7.905	23.2695	-3.1118	23.2618
HCC44	GDSC1	8.465	20.1495	-1.2608	16.1131
NCI-H441	GDSC1	8.7731	24.417	-3.0739	21.5364
ChaGo-K-1	GDSC1	8.8139	23.8773	-2.7901	20.6443

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CBTCi002-A	GDSC1	-4.4692	5.9091	-5.9958	68.2818

Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE-5	GDSC1	-7.3404	1.9992	-7.9768	81.5209
KYSE-150	GDSC1	-4.6181	10.3466	-7.9047	63.8239
KYSE-140	GDSC1	-4.1287	3.6698	-4.9001	70.9942
KYSE-450	GDSC1	-3.3851	1.6298	-3.6115	72.7366
TE-15	GDSC1	-2.8896	7.4243	-4.8817	61.1085
TE-6	GDSC1	-2.1883	11.7392	-6.0326	55.8707
KYSE-270	GDSC1	-1.5756	7.1197	-3.3737	55.4117
TE-8	GDSC1	-0.8159	18.1588	-7.7562	50.4893
OE33	GDSC1	-0.5523	14.2663	-5.6211	49.6703
KYSE-520	GDSC1	-0.436	13.1893	-4.9925	49.1899
EC-GI-10	GDSC1	0.7679	16.3765	-5.4195	45.1737
TE-10	GDSC1	1.3778	11.1074	-2.2706	39.4541
KYSE-70	GDSC1	1.6984	10.3486	-1.6023	36.5942
OE21	GDSC1	1.8631	11.7067	-2.1205	37.1475
TE-4	GDSC1	1.8772	13.5981	-3.0441	38.889
KYSE-410	GDSC1	1.9898	14.6136	-3.4482	39.1499
KYSE-510	GDSC1	3.142	14.2651	-2.2778	32.9009
COLO 680N	GDSC1	3.3096	20.6257	-5.3174	37.9573
OE19	GDSC1	3.6811	23.5299	-6.4612	38.4325
TE-9	GDSC1	4.2865	23.6796	-6.041	36.5988
TE-1	GDSC1	4.982	10.0781	1.2346	11.2263
T.T	GDSC1	5.3284	16.1296	-1.4707	23.9016
KYSE-180	GDSC1	5.793	30.6702	-8.327	36.2893
TE-11	GDSC1	7.1887	18.7057	-1.4074	19.2267

Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TOV-112D	GDSC1	-6.2368	9.4961	-9.253	68.1852
A2780	GDSC1	-4.9274	9.7502	-7.9777	65.0972
TYK-nu	GDSC1	-3.4317	9.4483	-6.2895	61.2598
OV-90	GDSC1	-2.3661	16.5699	-8.4663	54.8927
RMG-I	GDSC1	-2.1966	15.0028	-7.5592	54.8391
JHOS-4	GDSC1	-2.1372	14.581	-7.3023	54.7823
ES-2	GDSC1	-1.7945	6.8775	-3.5046	56.6856
SK-OV-3	GDSC1	-1.5668	11.5218	-5.3121	53.7275
OVK18	GDSC1	-1.4073	14.637	-6.6192	52.5481
IGROV-1	GDSC1	-1.0878	16.9373	-7.4188	51.3265
EFO-27	GDSC1	-0.9704	11.8988	-4.8983	51.3417
DOV13	GDSC1	-0.3068	12.541	-4.5582	48.6131
Kuramochi	GDSC1	0.0059	20.7101	-8.2497	48.3021
OAW28	GDSC1	0.0874	12.9866	-4.3958	47.0048
OVCAR-4	GDSC1	0.2081	15.1104	-5.314	46.9514
OAW42	GDSC1	0.287	50.258	-22.6991	48.9795
OVCAR-3	GDSC1	1.1174	20.5336	-7.1629	45.1158
Caov-3	GDSC1	1.5087	9.098	-1.1696	36.279
OC 314	GDSC1	1.5455	18.1268	-5.5876	42.9585
OVCAR-8	GDSC1	1.7425	13.8543	-3.2917	39.7686
JHOS-2	GDSC1	1.9796	15.2127	-3.755	39.64
Caov-4	GDSC1	2.6193	12.6666	-1.9265	33.7865
TOV-21G	GDSC1	2.6811	17.1065	-4.0894	37.9511
OVCAR-5	GDSC1	2.9356	18.2805	-4.4593	37.7719
OVISE	GDSC1	2.944	36.5907	-13.6059	44.2018
EFO-21	GDSC1	2.9817	24.9678	-7.7633	41.1533
FU-OV-1	GDSC1	3.1283	15.6644	-2.9889	34.6117
OVKATE	GDSC1	5.3876	10.2141	1.4362	8.888
OVTOKO	GDSC1	5.8551	20.9492	-3.4545	28.4581
OV56	GDSC1	7.1217	17.7353	-0.9893	17.7261

Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
KP-4	GDSC1	-4.5663	-0.4918	-4.6173	83.7641
SUIT-2	GDSC1	-3.5598	3.7453	-4.3012	68.76
BxPC-3	GDSC1	-3.113	9.4052	-5.9403	60.2685
MZ-PC-1	GDSC1	-2.213	9.0233	-4.845	57.2535
SU.86.86	GDSC1	-1.4439	15.7331	-7.1781	52.5022
HuP-T4	GDSC1	-0.8878	6.745	-2.4975	51.5837
Panc 03.27	GDSC1	-0.3915	9.052	-3.0035	48.6298
PaTu 8902	GDSC1	-0.2851	22.3448	-9.3207	49.1402
Panc 04.03	GDSC1	-0.1625	8.9622	-2.7333	47.3097
QGP-1	GDSC1	0.32	30.248	-12.6968	48.2442
HPAF-II	GDSC1	0.7451	16.3927	-5.4482	45.2622
MIA PaCa-2	GDSC1	1.0634	18.0257	-5.9672	44.6121
KP-1N	GDSC1	1.0717	6.8337	-0.5231	36.5031
Panc 08.13	GDSC1	1.1903	18.9015	-6.2878	44.4478
CFPAC-1	GDSC1	1.7227	12.5511	-2.6647	38.7963
PaTu 8988t	GDSC1	1.7656	22.339	-7.4913	43.696
Capan-2	GDSC1	2.026	33.6739	-12.925	45.4085
HPAC	GDSC1	2.5296	38.0431	-14.6808	45.1317
PL4	GDSC1	2.6363	13.9496	-2.5518	35.2577
Capan-1	GDSC1	2.9925	18.1488	-4.3454	37.445
KP-3	GDSC1	3.9899	16.8941	-2.8922	31.8392
Hs 766T	GDSC1	5.2126	23.5035	-5.2153	33.3861
PSN1	GDSC1	6.0057	17.6214	-1.707	23.0238
HuP-T3	GDSC1	6.0834	29.0203	-7.28	34.5945
Panc 02.03	GDSC1	6.8469	29.965	-7.1629	33.0965
SW1990	GDSC1	7.1634	22.0433	-3.036	24.537
DAN-G	GDSC1	7.8655	21.5728	-2.3235	21.0047
YAPC	GDSC1	8.2342	25.7839	-4.0985	25.1455
AsPC-1	GDSC1	8.3487	26.2461	-4.2424	25.2707
Panc 10.05	GDSC1	8.6015	23.186	-2.6019	20.4665

Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MSTO-211H	GDSC1	-3.5929	17.8419	-10.2617	57.3993
NCI-H2052	GDSC1	-1.2603	24.4671	-11.2565	51.3032
IST-Mes1	GDSC1	1.0139	13.1487	-3.607	42.8549
NCI-H2452	GDSC1	1.4608	24.6603	-8.9139	45.0911
NCI-H28	GDSC1	2.1631	19.401	-5.681	41.3308
MPP 89	GDSC1	2.2489	12.9819	-2.408	36.3093

Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
22Rv1	GDSC1	-3.3235	5.2416	-4.5234	65.352
PC-3	GDSC1	-3.0869	10.483	-6.3807	59.4466
LNCaP clone FGC	GDSC1	-1.42	4.4139	-2.1792	56.1551
VCaP	GDSC1	-0.7315	11.0914	-4.2852	50.3895
DU145	GDSC1	1.5616	12.9072	-2.9865	39.9573

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A-253	GDSC1	9.2187	22.3901	-1.8318	16.8463

Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CHL-1	GDSC1	-9.1535	7.8205	-11.7311	74.6427
IPC-298	GDSC1	-9.0995	12.4068	-13.4535	70.1138
CP50-MEL-B	GDSC1	-8.6631	7.0325	-10.9213	74.964
SK-MEL-5	GDSC1	-8.5037	12.3738	-12.8142	69.3347
WM35	GDSC1	-8.3653	3.5116	-9.4786	79.8139
COLO 800	GDSC1	-8.0945	0.889	-8.5635	84.7355
G-361	GDSC1	-7.7549	8.8751	-10.6231	71.4968
A-431	GDSC1	-7.7399	4.0996	-8.9642	78.0071
Mel JuSo	GDSC1	-7.5694	12.0938	-11.7191	68.1749
RVH-421	GDSC1	-7.0789	25.0336	-17.0577	60.7691
IGR-1	GDSC1	-6.7721	1.5213	-7.2556	81.8661
Mel Ho	GDSC1	-6.6477	2.9839	-7.462	78.45
SK-MEL-28	GDSC1	-6.5078	16.9766	-12.759	63.2387
A-375	GDSC1	-6.4873	7.5664	-8.7715	70.82
HT-144	GDSC1	-6.4839	29.9965	-18.8473	58.6636
VMRC-MELG	GDSC1	-6.3899	15.2307	-11.856	64.0205
SK-MEL-2	GDSC1	-6.3686	7.1389	-8.4859	71.1289
MZ-MEL-7	GDSC1	-6.1366	7.7776	-8.4751	69.8706
MZ-MEL-2	GDSC1	-6.0112	16.1166	-11.8689	62.86
WM793	GDSC1	-5.9735	17.7302	-12.5649	61.9767
WM115	GDSC1	-5.4345	11.4602	-9.2268	64.7887
SK-MEL-30	GDSC1	-5.3973	10.1957	-8.655	65.7733
G-mel	GDSC1	-5.1822	7.2818	-7.2662	68.3502
IGR-37	GDSC1	-4.9775	10.2697	-8.2469	64.7544
SK-MEL-3	GDSC1	-4.9112	14.926	-10.2202	61.4251
WM1552C	GDSC1	-4.0943	35.3053	-19.1851	54.7762
RPMI-7951	GDSC1	-4.0576	15.4674	-9.612	59.3361
SH-4	GDSC1	-3.5761	21.8987	-12.1777	56.2285
COLO 792	GDSC1	-3.1731	4.1964	-4.0155	66.3421
COLO 679	GDSC1	-2.8241	7.1782	-4.7138	61.0826
451Lu	GDSC1	-2.6762	24.647	-12.6565	54.0422
IST-MEL1	GDSC1	-2.4322	21.9212	-11.1025	53.9822
Hs 938.T	GDSC1	-2.309	24.4714	-12.2281	53.38
MMAc-SF	GDSC1	-2.1393	28.7193	-14.1531	52.6417
M14	GDSC1	-1.3701	48.1569	-23.0953	50.8033
COLO 829	GDSC1	-0.6841	191.7584	-94.2327	50.0115
LOX-IMVI	GDSC1	-0.3949	28.2607	-12.3454	49.5265
SK-MEL-24	GDSC1	-0.0451	11.9062	-4.003	47.3681
Hs 940.T	GDSC1	0.2334	52.2252	-23.7271	49.0754
A101D	GDSC1	1.1864	52.2826	-22.9379	48.0383
A-388	GDSC1	1.2352	22.8715	-8.2209	45.3076
CP66-MEL	GDSC1	1.2801	17.6232	-5.5736	43.7173
DJM-1	GDSC1	1.3602	28.5272	-10.9291	45.9915
COLO 783	GDSC1	1.6666	21.6331	-7.2259	43.7762
HMV-II	GDSC1	1.9746	35.77	-14.016	45.7778
LB373-MEL-D	GDSC1	2.8653	37.45	-14.1015	44.4787
SK-MEL-1	GDSC1	3.1258	42.5216	-16.4188	44.7845
GAK	GDSC1	4.3583	26.2483	-7.2659	37.8578
UACC-257	GDSC1	4.8941	28.5883	-8.0023	37.5694
LB2518-MEL	GDSC1	5.4248	26.8507	-6.7148	35.1145
WT2-iPS	GDSC1	5.4827	7.0579	2.841	0.4501
A2058	GDSC1	7.5167	25.5603	-4.4985	27.3702
UACC-62	GDSC1	7.9906	21.9773	-2.4328	21.1033
WM278	GDSC1	8.1132	25.1606	-3.8812	24.8519
MeWo	GDSC1	10.0386	32.8824	-6.2771	26.5812

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuTu 80	GDSC1	2.0361	19.6091	-5.895	41.8648

Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
GCT	GDSC1	-8.6794	12.1933	-12.9242	69.7257
Hs 633.T	GDSC1	-8.6266	0.9137	-9.1443	85.0847
SK-UT-1	GDSC1	-7.4139	15.6092	-13.0695	65.4442
Rh41	GDSC1	-6.7097	-4.5242	-6.7098	98.5325
EW-8	GDSC1	-5.956	-2.3439	-5.9674	92.4336
G-402	GDSC1	-5.4274	8.2645	-7.9061	67.7743
Rh30	GDSC1	-4.6765	3.6466	-5.4912	72.7479
RD	GDSC1	-4.2457	27.0435	-15.2958	56.2494
G-401	GDSC1	-4.2007	7.4007	-6.2637	65.5694
SK-LMS-1	GDSC1	-3.0055	6.3638	-4.5896	62.6515
A-204	GDSC1	-2.8834	36.7895	-18.8081	53.0843
SW872	GDSC1	-2.7212	14.6856	-7.9248	56.3853
Rh18	GDSC1	-1.552	12.0745	-5.5534	53.5333
VA-ES-BJ	GDSC1	-0.0968	47.5441	-21.6774	49.3711
KYM-1	GDSC1	0.2142	11.9202	-3.7612	46.16
SW982	GDSC1	0.8729	25.9062	-10.0497	46.7102
RKN	GDSC1	1.3087	35.6384	-14.5214	46.8967
HT-1080	GDSC1	1.3771	11.9565	-2.6872	40.1928
SW684	GDSC1	1.3856	15.3486	-4.3522	42.3287
MFH-ino	GDSC1	3.4256	26.4544	-8.1351	40.5237
MES-SA	GDSC1	9.1413	22.3683	-1.87	17.1137

Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
AGS	GDSC1	-5.858	12.7181	-10.2063	64.6986
GCIY	GDSC1	-5.4474	7.6025	-7.6716	68.5877
HSC-39	GDSC1	-5.1171	7.0984	-7.1274	68.4198
23132/87	GDSC1	-5.0398	26.4542	-15.7654	57.5598
Fu97	GDSC1	-3.9337	12.1145	-7.9673	60.818
RERF-GC-1B	GDSC1	-2.7605	17.2575	-9.1752	55.6923
ECC10	GDSC1	-2.557	11.1488	-6.1365	57.3632
Hs 746.T	GDSC1	-1.9518	16.5976	-8.0797	53.7951
SNU-1	GDSC1	-1.9355	36.7484	-17.9318	51.8254
MKN7	GDSC1	-0.936	9.0261	-3.5403	51.5136
KATO III	GDSC1	-0.6788	21.2531	-9.1432	50.0864
TGBC11TKB	GDSC1	-0.48	12.7204	-4.8106	49.3425
IM95	GDSC1	-0.0316	44.3287	-20.0175	49.2443
MKN1	GDSC1	0.1162	26.5949	-11.0626	48.4381
SCH	GDSC1	1.032	16.3234	-5.1534	44.1665
OCUM-1	GDSC1	1.6881	42.4977	-17.6215	46.8772
RF-48	GDSC1	4.4607	14.9496	-1.5478	26.5948
SNU-16	GDSC1	4.7022	6.0267	2.9068	0.7675
NUGC-4	GDSC1	4.892	14.6103	-1.0478	23.4948
SNU-5	GDSC1	5.2822	6.845	2.8398	0.5737
NCI-N87	GDSC1	5.9223	15.0563	-0.5179	18.4785
HGC-27	GDSC1	6.2395	28.8525	-7.076	34.0555
NUGC-3	GDSC1	6.2563	34.9752	-10.1062	37.1935
MKN45	GDSC1	7.0368	23.187	-3.6843	26.4666
MKN28	GDSC1	7.5525	19.949	-1.7575	19.74
SNG-M	GDSC1	-1.1796	5.8709	-2.4518	53.7003

Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
8505C	GDSC1	-9.1049	8.3559	-11.874	73.9732
KMH-2	GDSC1	-8.6687	3.66	-9.8511	79.9009
K5	GDSC1	-8.3143	7.887	-10.8521	73.4466
IHH-4	GDSC1	-8.0259	7.71	-10.4772	73.2385
TT2609-C02	GDSC1	-7.736	13.0434	-12.2922	67.6868
HTC-C3	GDSC1	-7.2895	5.6775	-8.9695	74.8091
CAL-62	GDSC1	-5.7754	13.3908	-10.4148	64.0714
B-CPAP	GDSC1	-3.209	32.482	-16.9843	53.92
BHT-101	GDSC1	1.4249	19.2287	-6.2419	43.7756
CGTH-W-1	GDSC1	1.5826	10.3145	-1.6928	37.3274
ASH-3	GDSC1	2.6859	11.3069	-1.1907	31.3208
ML-1 [Human leukemia]	GDSC1	3.7344	16.3185	-2.8126	32.3863
8305C	GDSC1	4.8452	27.7849	-7.6406	37.2957
TT	GDSC1	5.7652	7.1864	2.9001	0.1927
WRO	GDSC1	7.3385	30.7633	-7.1867	32.2907
FTC-133	GDSC1	9.8644	25.8697	-3.049	19.5884

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SCC-15	GDSC1	-9.0874	6.9469	-11.3499	75.6125
SCC-25	GDSC1	-3.4352	21.5669	-11.8837	56.041
BHY	GDSC1	-3.2095	27.1961	-14.3971	54.5903
SCC-9	GDSC1	-2.943	25.5847	-13.3627	54.3812
NCI-H3118	GDSC1	-2.8223	17.7223	-9.4559	55.7126
PE/CA-PJ15	GDSC1	-2.2702	18.9105	-9.4941	54.1489
PCI-04B	GDSC1	-2.0182	13.3046	-6.5869	54.7817
OSC-20	GDSC1	-1.6285	66.5343	-32.4773	50.7923
BB30-HNC	GDSC1	-0.5565	41.6673	-19.1504	49.8868
Ca9-22	GDSC1	-0.2839	18.6602	-7.5071	48.9748
BICR 31	GDSC1	-0.1441	25.6399	-10.8221	48.9456
JHU-011	GDSC1	-0.1107	30.0582	-12.9838	49.0362
PCI-06A	GDSC1	0.6775	30.0144	-12.2662	47.5462
PCI-15A	GDSC1	1.4805	21.1922	-7.1695	44.202
DOK	GDSC1	1.9608	11.657	-2.0077	36.4987
CAL-33	GDSC1	2.6541	13.53	-2.3271	34.6764
SAT [Human HNSCC]	GDSC1	2.9727	10.6649	-0.6225	28.089
HO-1-N-1	GDSC1	3.3074	15.802	-2.9074	33.8831
BICR 22	GDSC1	3.6361	7.2975	1.6137	12.6172
Detroit 562	GDSC1	3.9413	7.8893	1.5568	12.0192
SKN-3	GDSC1	4.07	6.6636	2.2529	6.4212
HSC-2	GDSC1	4.4492	6.6715	2.4966	3.6923
BICR 10	GDSC1	4.5689	22.263	-5.1066	34.6436
HSC-3	GDSC1	4.8651	11.1433	0.6372	15.2981
SAS	GDSC1	5.1051	7.5597	2.4708	2.6477
PCI-30	GDSC1	5.3921	7.434	2.6615	1.2311
PCI-38	GDSC1	5.4936	7.0489	2.8484	0.4218
BICR 78	GDSC1	5.5628	7.6741	2.6429	1.1513
HO-1-u-1	GDSC1	5.6057	7.6714	2.6625	1.0273
HSC-4	GDSC1	5.7667	7.0856	2.9347	0.1341
BB49-HNC	GDSC1	5.8889	7.6375	2.7882	0.4044
FaDu	GDSC1	5.8953	7.3101	2.9036	0.1545
KON	GDSC1	5.9276	7.5021	2.8496	0.2442
KOSC-2	GDSC1	6.0115	18.6013	-2.1827	24.589
CAL-27	GDSC1	6.2467	14.3566	0.0382	15.0116
LB771-HNC	GDSC1	6.3451	17.7752	-1.5398	21.6143
OSC-19	GDSC1	6.5858	15.9181	-0.48	16.7175
SCC-4	GDSC1	6.9757	36.0883	-10.0999	36.1038
JHU-022	GDSC1	7.6916	17.9637	-0.7282	15.4452

Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RT-112	GDSC1	-3.3568	5.0946	-4.5089	65.6973
UM-UC-3	GDSC1	-2.3998	3.4908	-2.9628	63.5962
RT-4	GDSC1	-1.4319	20.3143	-9.3822	51.9629
SW1710	GDSC1	-0.4573	7.2264	-2.2551	48.7951
639V	GDSC1	0.1901	10.966	-3.3274	45.978
CAL-29	GDSC1	0.2349	9.3475	-2.5183	45.093
SW780	GDSC1	0.5045	21.5616	-8.2201	47.0505
5637	GDSC1	0.6978	13.5284	-4.0856	44.4922
T24	GDSC1	0.9364	11.9397	-3.088	42.5581
HT-1376	GDSC1	1.5796	7.8741	-0.5126	33.7566
HT-1197	GDSC1	1.7185	16.3448	-4.5488	41.4674
TCCSUP	GDSC1	2.1122	13.7139	-2.8927	37.7815
J82	GDSC1	2.1333	12.0296	-2.0376	35.8928
647V	GDSC1	2.4218	16.2533	-3.8867	38.4255
KU-19-19	GDSC1	4.4341	14.2839	-1.2374	25.5605
BFTC-905	GDSC1	4.7435	20.8388	-4.2576	32.7741

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Ca Ski	GDSC1	-8.8605	6.9181	-11.0946	75.3642
KGN	GDSC1	-7.0727	3.6043	-8.0939	77.9172
SKN	GDSC1	-6.2495	12.3642	-10.4587	65.703
ME-180	GDSC1	-6.02	14.795	-11.2853	63.632
C-33 A	GDSC1	-5.4875	5.4182	-6.9278	71.6971
NEC8	GDSC1	-4.051	5.168	-5.286	68.0952
BPH-1	GDSC1	-3.9256	2.0357	-4.273	73.9481
HEY	GDSC1	-3.8281	7.7082	-5.9885	64.0948
TC-YIK	GDSC1	-3.6546	10.5226	-6.9819	61.1224
UWB1.289	GDSC1	-3.582	5.7647	-4.9873	65.5984
DSH1	GDSC1	-2.806	17.2661	-9.2233	55.7984
OVCA433	GDSC1	-2.7666	8.5033	-5.1971	59.7325
OMC-1 [Human cervical carcinoma]	GDSC1	-2.5548	14.3712	-7.614	56.037
SW962	GDSC1	-2.3857	10.7303	-5.7749	56.9892
PA-1	GDSC1	-1.5328	6.4024	-3.0367	55.5719
NCC-IT	GDSC1	-1.2784	9.962	-4.309	52.9489
OVMIU	GDSC1	-0.5413	15.452	-6.1831	49.6562
NT2-D1	GDSC1	-0.4622	10.2917	-3.6464	49.1209
PWR-1E	GDSC1	-0.2453	9.0846	-2.8722	47.8139
JAR	GDSC1	0.0782	5.1237	-0.8217	43.6912
PEO1	GDSC1	0.2686	10.3814	-2.9732	45.3464
SW954	GDSC1	0.5709	9.7489	-2.3799	43.2767
JEG-3	GDSC1	1.5982	14.7596	-3.8696	41.069
ACC-OV7	GDSC1	2.0788	12.4295	-2.2846	36.6716
SiSo	GDSC1	2.1811	16.4558	-4.1969	39.6088
SiHa	GDSC1	2.4904	43.3561	-17.3698	45.813
LB831-BLC	GDSC1	2.5878	14.6714	-2.9539	36.2705
CAL-39	GDSC1	3.0878	12.4749	-1.4288	30.6239
JHOS-3	GDSC1	3.0923	15.1912	-2.7827	34.2742
OVCA420	GDSC1	3.633	21.0923	-5.2823	37.1122
HT-3	GDSC1	4.0485	15.1868	-1.9926	29.2536
OV17R	GDSC1	4.0739	21.7583	-5.2539	36.0153
C-4-I	GDSC1	4.5883	19.9359	-3.9306	32.5181
MS751	GDSC1	4.8948	13.7099	-0.6011	21.6112
DoTc2 4510	GDSC1	5.0005	7.2836	2.5343	2.426
HEC-1	GDSC1	5.363	34.0112	-10.3327	38.7654
SW756	GDSC1	6.8986	16.3442	-0.4761	15.9979
HeLa	GDSC1	7.7869	24.203	-3.6455	24.8886
SKG-IIIa	GDSC1	8.3931	21.4706	-1.926	18.6692

References

• [1] Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett. 2012 Nov 7;4(1):91-7.