Details of the Drug

General Information of Drug (ID: DMJ0A2R)

Drug Name
IU1
Synonyms
314245-33-5; 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone; 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one; IU-1; 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone; 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone; CHEMBL1410015; MFCD01917473; 1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethan-1-one; 1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone; Usp14 inhibitor; MLS001032847; GTPL8880; SCHEMBL6923146; ZINC38235; DTXSID80350196; HMS1726C11; HMS2742M13; HMS3653I09; HMS3743A07; AMY24153; BCP12722; EX-A2079; 2486AH; BDBM50437694; s7134; AKOS000811299; IU1, >=98% (HPLC); CCG-190730; CS-7546; MCULE-9620933012; NE48827; QC-8208; SB19054; NCGC00249377-01; NCGC00249377-04; NCGC00249377-08; AC-32694; DA-33458; HY-13817; SMR000363441; ST054127; AB0097167; FT-0716455; MLS001032847-02; SW219677-1; EN300-72884; SR-01000010584; J-018415; SR-01000010584-1; Z55133506; F1142-1244; 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidinylethan-1-one; 1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYLPYRROL-3-YL]-2-(PYRROLIDIN-1-YL)ETHANONE
Indication
Disease Entry ICD 11 Status REF
Neurodegenerative disorder 8A20-8A23 Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 300.4
Logarithm of the Partition Coefficient (xlogp) 3.5
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C18H21FN2O
IUPAC Name
1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
Canonical SMILES
CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
InChI
InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
InChIKey
JUWDSDKJBMFLHE-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
675434
CAS Number
314245-33-5
TTD ID
DW0Z1Y

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ubiquitin carboxyl-terminal hydrolase 14 (USP14) TTVSYP9 UBP14_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 136 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 5.0746 9.6579 3.3772 13.2184
MEC1 CTRP2 5.6344 6.4388 5.4505 3.4204
JM1 CTRP2 5.5017 6.3055 5.3649 4.1137
EoL-1 CTRP2 2.6322 4.9082 2.558 22.984
SU-DHL-8 CTRP2 4.5822 6.3273 3.9863 5.8155
NALM-6 CTRP2 4.6439 5.9562 4.5391 9.6947
AML-193 CTRP2 4.916 5.7503 4.879 7.644
KHM-1B CTRP2 4.9553 7.0692 4.4766 9.717
BL-70 CTRP2 4.9887 5.6915 4.9659 7.1104
Peer CTRP2 4.9945 6.6183 4.7032 8.0601
KMS-21-BM CTRP2 5.0245 6.3409 4.8383 7.4629
GA-10 CTRP2 5.0749 13.3278 1.5662 20.1937
Ku812 CTRP2 5.0854 6.7269 4.756 7.6062
NCO2 CTRP2 5.0974 6.6346 4.8061 7.3797
Kasumi-2 CTRP2 5.1009 6.0979 4.9997 6.6417
KMS-34 CTRP2 5.1711 6.3841 4.981 6.5054
Mono-Mac-1 CTRP2 5.2278 9.0003 3.2171 7.8543
F-36P CTRP2 5.233 7.2291 4.6897 7.482
MOLM-13 CTRP2 5.274 6.288 5.1264 5.6633
SU-DHL-6 CTRP2 5.2851 7.7921 3.8656 4.831
MOLT-13 CTRP2 5.289 8.2021 4.2858 8.9918
P12-Ichikawa CTRP2 5.3169 6.8236 4.9562 6.2044
Daudi CTRP2 5.348 6.3372 5.1883 5.2183
SEM CTRP2 5.3606 6.2622 5.2291 5.0283
MM1.S CTRP2 5.3649 7.4913 4.6984 7.1217
A4/Fukuda CTRP2 5.3695 6.3122 5.2206 5.0352
KMS-12-BM CTRP2 5.3985 6.8525 5.0268 5.7128
MOLM-16 CTRP2 5.3998 8.3518 3.6768 5.4619
Hs 611.T CTRP2 5.4019 6.3686 5.2341 4.8924
Ki-JK CTRP2 5.4579 7.0487 4.9971 5.6824
Ri-1 CTRP2 5.4777 8.9784 4.0819 9.411
LP-1 CTRP2 5.4818 6.6584 5.1978 4.818
CML-T1 CTRP2 5.4957 6.9953 5.0594 5.3371
MHH-CALL-4 CTRP2 5.5118 8.0725 3.9001 4.2637
DB CTRP2 5.5468 6.3211 5.4069 3.827
SU-DHL-1 CTRP2 5.5478 6.709 5.2426 4.4695
HuNS1 CTRP2 5.55 6.5806 5.302 4.2277
SUP-T11 CTRP2 5.5576 6.576 5.3118 4.1692
SUP-B15 CTRP2 5.5588 6.363 5.403 3.8091
GDM-1 CTRP2 5.5615 7.1511 5.0507 5.2129
KE-97 CTRP2 5.5624 6.4728 5.3612 3.9619
MOLP-8 CTRP2 5.5658 6.298 5.4362 3.6619
ALL-SIL CTRP2 5.569 7.5979 4.843 6.0492
Mino CTRP2 5.5797 5.9463 5.5603 3.1625
RS4;11 CTRP2 5.6113 6.8792 5.2276 4.3722
SUP-HD1 CTRP2 5.6281 7.5209 4.9359 5.5303
BV-173 CTRP2 5.6423 7.0275 5.1876 4.4608
NB4 CTRP2 5.6512 6.9856 5.2162 4.3224
EM-2 CTRP2 5.6803 7.2522 5.1155 4.6691
RPMI-8402 CTRP2 5.6865 7.1465 5.1726 4.4194
OCI-Ly3 CTRP2 5.6966 6.4452 5.5117 3.0153
THP-1 CTRP2 5.7402 7.7658 4.9187 5.3535
HuT 78 CTRP2 5.7595 9.2431 4.2019 8.3117
MOLT-16 CTRP2 5.7718 7.1642 5.2437 3.9315
OCI-AML-2 CTRP2 5.8028 6.5289 5.5799 2.475
RL CTRP2 5.8078 6.7041 5.5013 2.7847
Karpas-422 CTRP2 5.8379 6.4605 5.6464 2.1193
KMS-26 CTRP2 5.8643 7.1327 5.3437 3.3122
Granta-519 CTRP2 5.8786 6.7542 5.5433 2.4498
DND-41 CTRP2 5.8913 7.979 4.9467 4.9182
P31/FUJ CTRP2 5.8969 7.2645 5.3074 3.3948
RPMI-8226 CTRP2 5.9117 8.8348 4.5371 6.5965
KMS-20 CTRP2 5.9126 7.7514 5.0787 4.321
KMS-27 CTRP2 5.9354 8.1004 4.9242 4.9232
HL-60 CTRP2 5.9488 6.6664 5.6505 1.8498
K-562 CTRP2 5.9674 8.0117 4.9959 4.558
L-363 CTRP2 5.9749 6.7327 5.6407 1.836
RCH-ACV CTRP2 5.9828 9.3741 3.6029 4.7879
KE-37 CTRP2 5.9878 6.8276 5.6047 1.9603
KO52 CTRP2 6.0154 6.6805 5.7019 1.4967
M-07e CTRP2 6.0204 7.9284 5.0824 4.0902
JJN-3 CTRP2 6.0239 7.6368 5.2311 3.4584
WSU-DLCL2 CTRP2 6.0319 6.9271 5.5926 1.9231
HT CTRP2 6.0445 6.945 5.5942 1.8922
EJM CTRP2 6.0459 7.2091 5.4633 2.4395
MOLM-6 CTRP2 6.0598 8.259 4.1839 2.2104
JeKo-1 CTRP2 6.071 7.0017 5.5877 1.8689
U-937 CTRP2 6.0741 7.4432 5.3696 2.7796
Karpas-299 CTRP2 6.0909 9.0485 4.5809 6.0624
SU-DHL-4 CTRP2 6.0963 8.4025 4.14 2.3422
MOTN-1 CTRP2 6.0972 7.5703 5.325 2.9235
DEL CTRP2 6.1104 7.4254 5.4081 2.5501
TF-1 CTRP2 6.1136 6.9536 5.6461 1.5453
SIG-M5 CTRP2 6.1334 6.9234 5.6767 1.3823
MHH-CALL-3 CTRP2 6.1519 7.7114 5.2987 2.9332
EHEB CTRP2 6.1541 8.3855 4.9639 4.3343
Ci-1 CTRP2 6.1583 7.3094 5.5041 2.0604
OCI-AML-3 CTRP2 6.1585 7.2407 5.5385 1.9162
JURL-MK1 CTRP2 6.159 7.7386 5.2908 2.9534
SKM-1 CTRP2 6.1618 7.9031 5.211 3.2831
LAMA-84 CTRP2 6.2009 7.8179 5.2844 2.9048
KM-H2 CTRP2 6.2285 8.871 4.7815 4.9637
Kasumi-1 CTRP2 6.2386 7.6129 5.4155 2.2914
L-428 CTRP2 6.2449 7.8485 5.3035 2.7482
Jurkat CTRP2 6.2521 8.5981 4.9362 4.2724
OCI-Ly19 CTRP2 6.2626 7.7044 5.3885 2.3632
U266B1 CTRP2 6.2695 8.0092 5.2427 2.9597
OCI-AML-5 CTRP2 6.2809 7.2874 5.6072 1.4282
KCL-22 CTRP2 6.2843 8.9547 4.784 4.8526
KMS-11 CTRP2 6.3151 7.7753 5.3929 2.2584
TALL-1 [Human adult T-ALL] CTRP2 6.3305 9.7933 4.4027 6.3672
SR CTRP2 6.3523 7.8181 5.3992 2.1722
HDLM-2 CTRP2 6.3823 8.4985 5.0863 3.4202
SET-2 CTRP2 6.3858 7.7276 5.4675 1.8398
SU-DHL-10 CTRP2 6.4046 7.2989 4.7551 0.101
MC116 CTRP2 6.4171 7.1559 4.8085 0.0401
HEL 92.1.7 CTRP2 6.4839 7.6825 5.5563 1.3423
P3HR-1 CTRP2 6.5288 8.6838 4.2622 1.3928
HD-MY-Z CTRP2 6.5546 8.8509 5.0403 3.3319
OCI-Ly10 CTRP2 6.57 8.2996 5.3191 2.1712
NU-DHL-1 CTRP2 6.6342 8.6611 5.189 2.6039
AMO1 CTRP2 6.8171 8.0007 4.6611 0.1405
NU-DUL-1 CTRP2 6.8489 8.4613 4.505 0.4298
KYO-1 CTRP2 6.8645 8.7899 4.3837 0.7384
JVM-3 CTRP2 6.9189 9.6958 4.8861 3.6703
PL21 CTRP2 6.9224 9.9934 4.7451 3.9812
SUP-T1 CTRP2 6.9936 21.7206 -1.0174 23.953
HEL CTRP2 7.0032 8.529 5.4808 1.0375
L-540 CTRP2 7.1798 8.6057 4.5826 0.1693
KMS-18 CTRP2 7.2056 11.3996 3.4361 3.8036
KMS-28BM CTRP2 7.3265 10.8166 3.765 2.4173
ME1 CTRP2 7.5585 9.1567 5.4962 0.5695
CMK CTRP2 7.5836 8.8209 5.6361 0.2362
OCI-M1 CTRP2 7.6481 8.9321 5.6209 0.2425
MOLP-2 CTRP2 7.7367 9.5632 5.4156 0.6797
REC-1 CTRP2 7.7897 9.3869 4.5322 0.1175
EB1 CTRP2 7.8389 23.6175 -1.2951 23.157
RPMI-6666 CTRP2 7.9698 9.4799 5.5475 0.2699
OPM-2 CTRP2 8.1199 26.8969 -2.7067 25.737
Reh CTRP2 8.1808 9.6477 5.5681 0.1777
Raji CTRP2 8.1858 9.3749 5.6641 0.0683
KMM-1 CTRP2 8.2457 16.4026 2.5654 10.6434
MJ CTRP2 8.3034 10.7745 5.1918 0.9434
Karpas-620 CTRP2 8.3784 9.8482 5.5706 0.134
Pfeiffer CTRP2 8.5115 25.6158 -1.769 23.1569
HPB-ALL CTRP2 10.8024 21.1913 1.9734 9.3364
⏷ Show the Full List of 136 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 6.5759 9.0391 4.9636 3.6141
TE8 CTRP2 6.7358 9.898 4.659 4.6167
EC-GI-10 CTRP2 6.1474 7.3912 5.4548 2.2866
TE-11 CTRP2 6.2409 8.3598 5.0461 3.832
KYSE-30 CTRP2 6.2637 7.8339 5.3252 2.6253
TE-5 CTRP2 6.3344 7.7277 5.4305 2.0717
OE21 CTRP2 6.4846 8.5014 5.1607 2.9464
KYSE-150 CTRP2 6.489 8.4414 5.1932 2.8055
KYSE-140 CTRP2 6.5227 18.049 0.4359 20.8887
KYSE-70 CTRP2 6.552 8.2027 5.3534 2.0586
KYSE-410 CTRP2 6.6407 8.435 5.3021 2.1394
TE-6 CTRP2 6.6777 9.0832 5.0149 3.4877
TE-9 CTRP2 6.8201 9.4862 4.9192 3.4253
TE-4 CTRP2 6.9416 9.4372 5.0249 2.8316
COLO 680N CTRP2 7.0995 10.5233 4.6116 4.2645
TE-10 CTRP2 7.119 11.5702 4.1178 6.2399
KYSE-450 CTRP2 7.2332 9.7596 5.0592 2.3307
TE-14 CTRP2 7.3365 9.9506 5.0342 2.3052
KYSE-510 CTRP2 7.6696 9.4628 5.4248 0.6958
TE-1 CTRP2 7.7347 10.9112 4.8337 2.6049
OE19 CTRP2 7.8701 9.1368 5.6328 0.1585
KYSE-520 CTRP2 8.9198 11.1257 5.3203 0.3709
KYSE-180 CTRP2 11.2791 24.4008 0.776 12.5259
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.522 7.8147 5.5186 1.4404
MIA PaCa-2 CTRP2 5.9441 6.7655 5.5972 2.0828
KP-4 CTRP2 5.9775 8.0977 4.9615 4.6825
Panc 03.27 CTRP2 6.2526 8.7568 4.8576 4.6011
Panc 10.05 CTRP2 6.2928 8.3622 5.0854 3.5763
PaTu 8988s CTRP2 6.3849 8.1357 5.2671 2.6658
SNU-410 CTRP2 6.4664 8.6094 4.261 1.4565
HuP-T4 CTRP2 6.5127 8.343 5.2581 2.5031
QGP-1 CTRP2 6.5944 8.1277 5.4178 1.7422
L3.3 CTRP2 6.7155 9.3038 4.9345 3.5183
PK-59 CTRP2 6.8157 9.233 5.0381 2.9524
PSN1 CTRP2 6.8351 9.419 4.9619 3.2314
KP-3 CTRP2 6.9013 12.4335 3.5328 8.9835
KP-2 CTRP2 6.9055 8.5867 5.399 1.4327
SW1990 CTRP2 6.942 9.0474 5.2088 2.1108
Panc 05.04 CTRP2 7.0118 9.7737 4.9113 3.1874
YAPC CTRP2 7.0331 8.4931 5.5127 0.9013
Capan-2 CTRP2 7.0703 9.759 4.9567 2.9296
AsPC-1 CTRP2 7.0737 15.4204 2.1842 13.9762
CFPAC-1 CTRP2 7.1423 9.689 5.0356 2.5306
Hs 766T CTRP2 7.2883 10.0252 4.9704 2.6028
SNU-213 CTRP2 7.3012 8.8257 5.509 0.6997
HPAF-II CTRP2 7.369 11.569 4.2928 5.5425
Panc 08.13 CTRP2 7.4102 10.4956 4.8279 3
Panc 04.03 CTRP2 7.4261 11.9514 4.148 5.6611
BxPC-3 CTRP2 7.4677 12.9632 3.6874 7.4509
PaTu 8902 CTRP2 7.5854 9.0943 5.5329 0.4611
SU.86.86 CTRP2 7.6433 9.2743 5.488 0.5429
TCC-Pan2 CTRP2 7.6592 13.3363 3.6407 7.3519
HPAC CTRP2 7.6863 9.4578 5.4346 0.6588
HuP-T3 CTRP2 7.7179 10.0809 5.1911 1.3715
SUIT-2 CTRP2 7.7221 11.3157 4.6411 3.3379
PK-45H CTRP2 7.812 10.2562 5.1652 1.3767
Panc 02.03 CTRP2 8.6954 15.4815 3.31 7.2035
DAN-G CTRP2 10.138 24.1004 0.1584 15.8229
PaTu 8988t CTRP2 13.5024 31.5327 -1.1498 15.0838
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 6.2891 8.0587 5.2332 4.9527
COLO 792 CTRP2 5.1666 7.4678 4.5138 8.3559
WM266-4 CTRP2 5.3886 5.8602 5.3693 4.4347
WT2-iPS CTRP2 5.458 6.0097 5.4136 4.0608
UACC-62 CTRP2 5.6085 6.0925 5.5548 3.0937
CJM [Human melanoma] CTRP2 5.6242 6.0204 5.5922 2.9109
Hs 944.T CTRP2 5.6339 8.8867 3.5897 5.4279
WM88 CTRP2 5.7876 6.3891 5.6294 2.313
G-361 CTRP2 5.9247 7.6591 5.1353 4.0588
SK-MEL-1 CTRP2 5.9487 6.7725 5.5978 2.0705
WM115 CTRP2 5.9582 7.1366 5.4249 2.7751
SK-MEL-28 CTRP2 6.0224 6.7421 5.677 1.5872
Mel Ho CTRP2 6.134 7.7515 5.2643 3.1102
Hs 895.T CTRP2 6.1599 7.4198 5.4504 2.2825
SK-MEL-5 CTRP2 6.1973 7.5063 5.4366 2.2743
Hs 940.T CTRP2 6.2995 9.4076 4.5704 5.7204
RVH-421 CTRP2 6.3199 7.7819 5.3932 2.249
UACC-257 CTRP2 6.3331 7.9031 5.3433 2.4345
MeWo CTRP2 6.3715 8.3157 5.1685 3.0965
RPMI-7951 CTRP2 6.4812 8.0757 5.3657 2.1119
WM983B CTRP2 6.5003 7.983 5.4237 1.8491
Hs 934.T CTRP2 6.5219 8.3664 5.2532 2.5093
Hs 294T CTRP2 6.6058 7.6352 5.6538 0.8229
K029AX CTRP2 6.693 7.9699 5.5534 1.0971
SK-MEL-3 CTRP2 6.7305 8.0052 5.5596 1.0331
MDA-MB-435S CTRP2 6.7381 9.8248 4.6965 4.4587
A-375 CTRP2 6.8329 9.352 4.9926 3.1107
Mel JuSo CTRP2 6.8625 9.6312 4.8785 3.5285
Hs 839.T CTRP2 6.91 8.4027 5.4846 1.116
SK-MEL-2 CTRP2 6.9702 7.9591 5.7046 0.3606
HT-144 CTRP2 7.1111 11.1543 4.3146 5.4503
Hs 688(A).T CTRP2 7.1155 11.1215 4.3336 5.3663
IGR-37 CTRP2 7.1214 8.3863 5.6026 0.5494
SK-MEL-30 CTRP2 7.1219 10.2952 4.736 3.7344
Hs 852.T CTRP2 7.138 11.9162 3.9625 6.8435
WM793 CTRP2 7.18 10.962 4.4555 4.7779
IPC-298 CTRP2 7.2354 8.5494 5.5904 0.5098
IGR-39 CTRP2 7.3274 14.7005 2.7335 11.4549
LOX-IMVI CTRP2 7.4286 9.2376 5.4005 0.9362
WM1799 CTRP2 7.5883 11.9152 4.2745 4.931
COLO 800 CTRP2 7.8216 9.4472 5.4988 0.4271
Hs 936.T CTRP2 7.8261 8.9001 5.6992 0.084
SK-MEL-31 CTRP2 8.289 9.6441 5.6088 0.1066
COLO 829 CTRP2 11.7643 25.4318 0.602 12.4516
HMCB CTRP2 12.7043 30.2977 -1.0825 15.8285
A2058 CTRP2 12.8507 38.6407 -4.9889 23.4441
A101D CTRP2 13.0964 34.9644 -3.0446 19.688
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 6.1534 9.0402 4.6364 5.7112
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kelly CTRP2 5.8048 6.7042 5.4984 2.8037
IMR-32 CTRP2 5.8939 6.4998 5.6816 1.8426
SK-N-FI CTRP2 5.9484 11.2369 3.3677 11.4049
SK-N-BE(2) CTRP2 6.002 8.3067 4.8777 4.9864
NH-6 CTRP2 6.0438 8.1543 4.989 4.4373
SK-N-DZ CTRP2 6.1684 7.545 5.3947 2.5006
SiMa CTRP2 6.4521 8.7419 5.0185 3.5861
MHH-NB-11 CTRP2 6.4878 10.2015 4.3228 6.4235
NB1 CTRP2 6.635 9.2011 4.9271 3.672
KP-N-SI9s CTRP2 6.7856 10.8552 4.2253 6.3269
CHP-126 CTRP2 7.1454 9.1446 4.3696 0.6151
KP-N-YN CTRP2 7.2608 8.961 4.4863 0.3063
SK-N-SH CTRP2 12.502 33.3685 -2.6825 19.6554
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 6.194 12.08 3.1503 11.8172
SNU-478 CTRP2 6.8885 10.733 4.3609 5.6028
HuCC-T1 CTRP2 7.1837 9.9614 4.9345 2.8702
HuH-28 CTRP2 7.3322 8.8793 5.502 0.6986
SNU-869 CTRP2 7.3554 10.3318 4.8699 2.906
SNU-1196 CTRP2 7.4364 9.5702 5.2618 1.3841
SNU-308 CTRP2 7.709 9.4414 5.4515 0.6004
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 5.923 6.8357 5.5435 2.3521
A-673 CTRP2 5.9962 6.8229 5.6143 1.903
SK-ES-1 CTRP2 6.1598 8.0944 5.1139 3.6943
TC71 CTRP2 6.2279 8.7964 4.8182 4.8107
MG-63 CTRP2 6.3503 7.6764 5.4672 1.8956
CADO-ES1 CTRP2 6.3986 8.8725 4.9136 4.1118
U2OS CTRP2 6.5974 8.6225 5.1821 2.8854
SaOS-2 CTRP2 6.7109 10.1335 4.5252 5.2085
Hs 822.T CTRP2 6.8682 8.3861 5.4679 1.2199
HOS CTRP2 6.9017 11.5731 3.9579 7.2397
CAL-78 CTRP2 7.1732 9.2581 5.2523 1.6795
SW1353 CTRP2 7.226 11.6031 4.1776 5.8346
Hs 888.T CTRP2 7.2624 10.339 4.8075 3.2643
G-292 clone A141B1 CTRP2 7.6812 10.457 5.0067 2.0361
MHH-ES-1 CTRP2 7.9875 17.4361 1.8756 13.5597
SJSA-1 CTRP2 9.5338 19.5637 1.9249 11.1015
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AU565 CTRP2 1.6977 11.0163 -5.6981 16.6386
HCC2218 CTRP2 4.4959 6.9784 4.0318 12.02
DU4475 CTRP2 4.8019 60.2964 -22.1239 43.8769
HCC1500 CTRP2 5.641 16.0035 0.7248 21.7629
MDA-MB-468 CTRP2 5.6943 15.6899 0.9268 21.0119
EFM-192A CTRP2 5.7532 7.7456 4.9404 5.235
Hs 578T CTRP2 5.8046 7.289 5.2124 3.9893
ZR-75-30 CTRP2 5.8482 7.141 5.3251 3.4246
MDA-MB-453 CTRP2 5.9731 7.7796 5.1167 4.0392
KPL-1 CTRP2 6.11 9.0203 4.6107 5.9009
CAL-51 CTRP2 6.2418 7.6123 5.4183 2.2744
MDA-MB-361 CTRP2 6.2792 7.922 5.2934 2.7314
MCF-7 CTRP2 6.2833 8.1875 5.1648 3.261
CAL-85-1 CTRP2 6.4516 9.0363 4.8728 4.1925
BT-549 CTRP2 6.4658 8.1154 5.3356 2.2575
CAL-148 CTRP2 6.4701 10.2272 4.2963 6.5651
HMC-1-8 CTRP2 6.4928 13.2218 2.8222 12.5724
HCC1419 CTRP2 6.5663 7.9918 5.4637 1.5981
HCC1428 CTRP2 6.567 8.044 5.4394 1.6934
BT-474 CTRP2 6.6359 9.9086 4.5804 5.1018
BT-20 CTRP2 6.8395 8.6868 5.3124 1.838
T-47D CTRP2 6.8758 10.3892 4.5198 4.9702
HCC1143 CTRP2 6.9308 11.2477 4.1394 6.4462
ZR-75-1 CTRP2 6.9479 10.8303 4.3563 5.5288
HCC1954 CTRP2 6.9823 11.9812 3.8168 8.2491
HCC1806 CTRP2 7.0628 9.2996 5.1669 2.2813
HCC202 CTRP2 7.088 9.8302 4.9346 2.9934
CAMA-1 CTRP2 7.1809 9.5922 5.1044 2.2211
HCC1395 CTRP2 7.464 12.3245 3.9943 6.2235
MDA-MB-231 CTRP2 7.5071 11.6132 4.3644 4.6855
JIMT-1 CTRP2 7.5462 8.9995 5.5527 0.4329
CAL-120 CTRP2 7.7588 9.0046 5.6378 0.1793
HCC1937 CTRP2 7.8397 11.2614 4.7367 2.8467
HCC38 CTRP2 7.958 10.8423 4.99 1.83
HDQ-P1 CTRP2 8.003 10.48 5.1679 1.2174
BT 498 CTRP2 1.6207 52.4854 -20.9583 46.7059
BT 239 CTRP2 4.1387 5.0751 4.129 12.7284
BT 271 CTRP2 4.7709 6.756 4.4116 9.7994
BT 231 CTRP2 5.0097 7.6859 4.2569 9.7823
BT 330 CTRP2 5.7596 7.1223 5.253 3.9204
BT164 CTRP2 5.8393 6.5482 5.6062 2.2801
BT 228 CTRP2 5.8894 7.5735 5.1471 4.0818
BT 112 CTRP2 5.9171 7.3996 5.258 3.5597
BT 248 CTRP2 6.0691 7.7464 5.2139 3.4434
BT 359 CTRP2 6.0847 9.7126 4.2438 7.4901
BT 145 CTRP2 6.1388 7.2532 5.5168 2.0421
BT 232 CTRP2 6.1683 9.1522 4.5925 5.8677
BT 187 CTRP2 6.1834 8.5188 4.921 4.4604
BT 245 CTRP2 6.2346 8.18 5.1307 3.4891
BT 340 CTRP2 6.2751 7.6531 5.4233 2.1978
BT 131 CTRP2 6.2808 7.8444 5.333 2.5641
BT 504 CTRP2 6.2883 7.6692 5.4252 2.1682
BT 286 CTRP2 6.3131 9.5658 4.5023 5.9811
BT147 CTRP2 6.3213 13.4294 2.58 13.846
BT 172 CTRP2 6.3748 13.6409 2.5178 13.986
BT 422 CTRP2 6.487 8.6825 5.0736 3.3018
BT 428 CTRP2 6.4899 8.5682 5.1317 3.0572
BT 444 CTRP2 6.5482 8.826 5.0479 3.3109
BT 482 CTRP2 6.5511 8.0882 5.4077 1.8417
BT 216 CTRP2 6.5967 8.7009 5.1436 2.8441
BT 333 CTRP2 6.6116 9.2195 4.9012 3.815
BT 416 CTRP2 6.6183 9.7272 4.6566 4.8147
BT 159 CTRP2 6.6576 8.2107 5.4197 1.6514
BT 224 CTRP2 6.6902 8.5397 5.2852 2.1387
BT 440 CTRP2 6.7598 9.1697 5.0303 3.0637
BT 139 CTRP2 6.793 8.0698 5.5666 0.9428
BT 328 CTRP2 6.8633 8.9857 5.1874 2.2944
BT 179 CTRP2 6.9099 9.536 4.9566 3.147
BT 320 CTRP2 7.0701 8.7892 5.4031 1.2442
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.306 10.3005 4.8534 3.0306
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-251MG CTRP2 5.8753 6.9389 5.4494 2.8479
D283 Med CTRP2 6.1714 7.2647 5.5366 1.9016
CAS-1 CTRP2 6.2898 8.3829 5.0729 3.6338
SF268 CTRP2 6.3755 9.6041 4.5324 5.744
A-172 CTRP2 6.3827 7.6635 5.4965 1.7261
DK-MG CTRP2 6.441 8.4331 5.1623 3.0089
8-MG-BA CTRP2 6.4533 9.1513 4.8172 4.4208
LN-229 CTRP2 6.489 8.4506 5.1887 2.8242
KNS-60 CTRP2 6.5043 8.0961 5.372 2.0525
Hs 683 CTRP2 6.5207 8.2367 5.3154 2.2579
SW1783 CTRP2 6.5322 8.4698 5.2103 2.6692
ONS-76 CTRP2 6.5408 8.4981 5.2026 2.6877
Daoy CTRP2 6.5611 8.234 5.3445 2.0814
SF539 CTRP2 6.6132 8.9958 5.0117 3.3582
GMS-10 CTRP2 6.6665 8.2376 5.4128 1.6667
M059K CTRP2 6.8114 10.255 4.5391 4.9913
42-MG-BA CTRP2 6.8283 8.9341 5.1889 2.3344
T98G CTRP2 6.8708 9.8402 4.7833 3.9021
SF295 CTRP2 6.9609 8.4783 5.4797 1.0823
KNS-81 CTRP2 7.0052 8.4702 5.5076 0.9437
GB-1 CTRP2 7.0745 9.0974 5.2669 1.7338
SNU-1105 CTRP2 7.1156 14.5467 2.6496 12.9633
SNU-738 CTRP2 7.1399 9.402 5.1669 2.0333
GaMG CTRP2 7.1504 9.6292 5.0685 2.3943
LN-18 CTRP2 7.1527 9.2823 5.2293 1.7862
SF126 CTRP2 7.1622 9.2915 5.2307 1.7705
GOS-3 CTRP2 7.25 9.9346 4.9887 2.579
U-87MG ATCC CTRP2 7.3097 8.9714 5.4524 0.9308
CCF-STTG1 CTRP2 7.3521 10.3745 4.8479 2.9945
SNU-626 CTRP2 7.4473 8.923 5.5385 0.5223
SNB-75 CTRP2 7.4956 12.3549 4.0014 6.1491
SNU-489 CTRP2 7.5042 8.9677 5.5465 0.47
KG-1-C CTRP2 7.5283 9.2185 5.4573 0.6952
DBTRG-05MG CTRP2 7.5581 11.2106 4.5875 3.7441
YH-13 CTRP2 7.6363 12.9167 3.8274 6.6415
SW1088 CTRP2 7.8832 12.5241 4.1789 4.9167
NMC-G1 CTRP2 7.929 9.4317 5.5489 0.2808
KALS-1 CTRP2 7.94 10.4706 5.14 1.3531
SNU-201 CTRP2 8.086 16.2712 2.5164 11.0684
U-118MG CTRP2 8.9711 16.6034 2.9593 8.155
TM-31 CTRP2 9.5201 20.5224 1.4572 12.694
Becker CTRP2 9.5939 17.9639 2.7192 8.2339
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-251 CTRP2 5.3743 6.7064 5.0662 5.6196
HEC-265 CTRP2 5.5492 8.0254 4.616 7.0333
JHUEM-7 CTRP2 5.8562 6.7602 5.5197 2.5977
HEC-108 CTRP2 5.8695 7.4721 5.18 3.9858
KLE CTRP2 5.9068 9.4563 4.2225 7.9268
MFE-319 CTRP2 5.9556 7.914 5.0346 4.4189
HEC-59 CTRP2 5.9985 7.778 5.139 3.895
HEC-1-A CTRP2 6.027 8.578 4.763 5.4197
JHUEM-1 CTRP2 6.0314 6.7392 5.6861 1.5315
RL95-2 CTRP2 6.0686 8.7587 4.7074 5.5733
JHUEM-2 CTRP2 6.1079 9.2685 4.4849 6.4333
HEC-151 CTRP2 6.168 7.1992 5.5665 1.7827
HEC-1-B CTRP2 6.4185 8.4471 5.1387 3.143
AN3-CA CTRP2 6.4391 8.1582 5.2957 2.4623
HEC-6 CTRP2 6.5648 8.3266 5.3025 2.2458
MFE-296 CTRP2 6.8829 9.3559 5.0245 2.9128
ESS-1 CTRP2 6.9006 9.6817 4.8803 3.4664
EN CTRP2 6.9306 8.3667 5.5121 0.9984
HEC-50B CTRP2 7.1972 9.0574 4.4249 0.4576
EFE-184 CTRP2 7.7885 9.883 5.3101 0.9451
JHUEM-3 CTRP2 7.8224 9.74 5.3844 0.8232
Ishikawa (Heraklio) 02 ER- CTRP2 6.8416 9.0272 5.1536 2.4564
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 6.4028 8.918 4.8943 4.1853
786-O CTRP2 6.6682 8.1918 5.4354 1.5765
KMRC-2 CTRP2 6.8726 9.1923 5.0956 2.6441
TUHR10TKB CTRP2 7.0207 8.0935 4.7017 0.0604
KMRC-3 CTRP2 7.0254 10.1817 4.7252 3.9132
OS-RC-2 CTRP2 7.1 8.9756 5.337 1.4499
KMRC-1 CTRP2 7.1391 12.1161 3.8655 7.2377
A-498 CTRP2 7.2066 9.032 5.3719 1.221
VMRC-RCZ CTRP2 7.4352 11.9757 4.1425 5.6702
Caki-2 CTRP2 7.5111 10.9448 4.682 3.4371
769-P CTRP2 7.5382 11.0272 4.6606 3.7442
BFTC-909 CTRP2 7.5852 9.2455 5.473 0.6159
ACHN CTRP2 7.6311 10.9009 4.7765 2.9332
Caki-1 CTRP2 7.6396 10.2436 5.0779 1.8265
SNU-1272 CTRP2 7.6964 11.2155 4.6715 3.2532
KMRC-20 CTRP2 7.9676 9.8639 5.4009 0.5881
TUHR4TKB CTRP2 8.0477 9.5135 5.5656 0.2154
RCC10RGB CTRP2 8.0499 9.3226 5.6339 0.1192
VMRC-RCW CTRP2 8.3355 15.514 3.0561 8.6575
TUHR14TKB CTRP2 8.7349 28.32 -2.9383 25.2344
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 CTRP2 5.7563 23.2307 -2.79 29.9646
SNU-C1 CTRP2 5.8095 6.6654 5.5216 2.6974
COLO 320 CTRP2 5.8753 13.2535 2.298 15.8091
LoVo CTRP2 5.9139 10.0139 3.9499 9.0548
SNU-C5 CTRP2 5.9589 9.38 4.3048 7.478
GP2d CTRP2 6.0966 8.2158 5.0019 4.282
SW1417 CTRP2 6.1202 7.6028 5.3275 2.8704
RKO CTRP2 6.1292 7.9114 5.1806 3.4704
NCI-H747 CTRP2 6.2001 8.5942 4.8969 4.5312
SNU-407 CTRP2 6.2886 8.2553 5.1353 3.3749
CCK-81 CTRP2 6.29 10.6072 3.9643 8.2752
COLO201 CTRP2 6.3148 8.2424 5.1618 3.2194
SNU-61 CTRP2 6.3153 7.8696 5.3465 2.4503
LS123 CTRP2 6.3175 7.7167 5.4235 2.1277
COLO 678 CTRP2 6.3485 7.7904 5.41 2.1339
SW620 CTRP2 6.3606 8.0894 5.2719 2.6854
T84 CTRP2 6.4116 9.2563 4.7332 4.8419
SW1116 CTRP2 6.4676 8.4674 5.1649 3.4148
KM12 CTRP2 6.4778 7.8312 5.4813 1.6494
LS180 CTRP2 6.5311 8.409 5.2391 2.553
SW48 CTRP2 6.5564 8.8853 5.0248 3.3929
HT115 CTRP2 6.5601 9.0164 4.9632 3.6406
SK-CO-1 CTRP2 6.5974 9.157 4.9214 3.7541
OUMS-23 CTRP2 6.6525 8.3164 5.3664 1.8675
COLO205 CTRP2 6.8847 9.0391 5.1761 2.3109
HCT 8 CTRP2 6.9739 8.6815 5.3963 1.3678
LS1034 CTRP2 6.9776 8.4496 5.5016 0.9901
SNU-1033 CTRP2 7.0318 10.4665 4.5924 4.44
LS411N CTRP2 7.1335 10.0513 4.8597 3.228
C2BBe1 CTRP2 7.1584 9.298 5.2255 1.7938
LS513 CTRP2 7.1639 9.339 5.2101 1.8446
CW-2 CTRP2 7.2353 9.0221 4.4537 0.3797
HT-55 CTRP2 7.3124 8.995 5.4438 0.8913
SW948 CTRP2 7.4139 8.6614 5.626 0.3247
MDST8 CTRP2 7.4284 8.8982 5.5398 0.5301
NCI-H716 CTRP2 7.4503 9.349 5.3644 1.033
DLD-1 CTRP2 7.4878 8.4799 5.7223 0.1206
SNU-503 CTRP2 7.4948 9.5044 5.3213 1.1352
RCM-1 [Human ESC] CTRP2 7.5201 9.0429 5.524 0.5188
CL-11 CTRP2 7.6158 10.1573 5.1028 1.7628
SNU-C4 CTRP2 7.6324 10.7073 4.8658 2.599
HCT 15 CTRP2 7.7247 13.8095 3.4574 7.9829
HT-29 CTRP2 7.8455 9.2743 5.5736 0.2634
NCI-H508 CTRP2 7.8709 9.6875 5.4271 0.5738
HCT 116 CTRP2 7.948 12.0568 4.4376 3.8415
SNU-C2A CTRP2 8.5087 18.7832 1.5937 14.5446
HCC-56 CTRP2 11.3676 23.4642 1.27 10.9186
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-886 CTRP2 4.0989 13.5941 0.5468 25.792
HuH-6 CTRP2 5.0111 9.029 3.6227 12.3604
PLC/PRF/5 CTRP2 5.8005 6.569 5.5588 2.5662
SNU-182 CTRP2 5.9122 11.6517 3.1298 12.4503
SNU-398 CTRP2 5.9625 12.0806 2.2591 10.6753
JHH-5 CTRP2 6.0522 7.0786 5.5337 2.1315
JHH-4 CTRP2 6.1204 8.0648 5.0968 3.8389
SNU-423 CTRP2 6.1432 7.4409 5.4266 2.4123
HLF CTRP2 6.4267 7.5565 5.5783 1.3325
SNU-761 CTRP2 6.4641 9.0366 4.882 4.4395
JHH-1 CTRP2 6.6132 10.777 4.1338 6.9944
Hep-G2 CTRP2 6.7998 8.3835 5.4283 1.4434
SNU-387 CTRP2 6.8804 8.8596 5.2575 1.9993
SNU-878 CTRP2 6.985 9.49 5.0283 2.76
SK-HEP-1 CTRP2 6.9894 16.6023 1.5308 16.4749
Li-7 CTRP2 7.0756 9.5152 5.0746 2.4628
SNU-475 CTRP2 7.3294 9.5057 5.231 1.5942
JHH-6 CTRP2 7.3357 7.9867 5.8371 0.0251
SNU-449 CTRP2 7.3912 10.4881 4.8195 3.0557
Hep 3B2.1-7 CTRP2 7.7412 9.5568 5.4203 0.7137
JHH-2 CTRP2 9.483 21.8379 0.7973 14.8538
HuH-1 CTRP2 13.6002 38.5938 -4.445 21.6982
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 132 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1581 CTRP2 4.5847 6.3671 4.3529 10.552
NCI-H2106 CTRP2 4.7545 8.3772 3.6836 12.7274
NCI-H1694 CTRP2 4.8573 6.3148 4.6661 8.5912
NCI-H1341 CTRP2 5.2126 6.629 4.9299 6.5857
NCI-H211 CTRP2 5.3183 8.4778 4.1799 9.3605
NCI-H2029 CTRP2 5.5563 6.871 5.1771 4.7117
NCI-H810 CTRP2 5.5595 6.2412 5.4509 3.6238
NCI-H1184 CTRP2 5.6786 7.5691 4.9592 5.3201
NCI-H1092 CTRP2 5.6844 7.0737 5.2057 4.2877
COR-L95 CTRP2 5.7681 7.6834 4.9846 5.0186
NCI-H1105 CTRP2 5.7755 7.3644 5.1488 4.3179
NCI-H1568 CTRP2 5.8565 7.0754 5.365 3.2403
NCI-H2196 CTRP2 5.8897 8.1057 4.8822 5.1921
NCI-H1563 CTRP2 5.906 10.2151 3.8426 9.5191
COLO 668 CTRP2 5.9129 7.088 5.4093 2.9347
NCI-H1703 CTRP2 5.9779 8.3514 4.835 5.2133
HCC1833 CTRP2 5.9873 14.0041 2.0169 16.6392
VMRC-LCD CTRP2 5.9943 7.1122 5.4682 2.5206
DV-90 CTRP2 6.0075 7.1216 5.4747 2.4668
KNS-62 CTRP2 6.0405 6.9922 5.5672 2.0131
NCI-H23 CTRP2 6.0505 7.9848 5.0793 4.0448
DMS 53 CTRP2 6.0695 18.852 -0.3385 23.9623
DMS 273 CTRP2 6.0939 7.5284 5.3432 2.853
NCI-H2087 CTRP2 6.1126 9.0609 4.5926 5.9719
HCC827 CTRP2 6.1224 8.5328 4.8646 4.8105
EKVX CTRP2 6.1296 9.0316 4.6212 5.8198
LK2 CTRP2 6.203 9.7504 4.3219 6.9391
NCI-H2081 CTRP2 6.2033 7.6378 5.3759 2.5178
NCI-H1155 CTRP2 6.2184 8.1899 5.113 3.5916
HCC4006 CTRP2 6.22 9.528 4.4467 6.3839
NCI-H522 CTRP2 6.2211 7.5318 5.4423 2.2096
NCI-H2342 CTRP2 6.2267 8.9388 4.7461 5.1153
EPLC-272H CTRP2 6.263 7.8656 5.3089 2.6946
RERF-LC-MS CTRP2 6.2871 9.6927 4.4183 6.3803
T3M-10 CTRP2 6.344 7.7056 5.4483 1.9831
NCI-H2110 CTRP2 6.3537 8.7626 4.9337 4.1048
NCI-H520 CTRP2 6.3703 8.1809 5.2341 2.8264
NCI-H1755 CTRP2 6.3812 9.7134 4.4825 5.9431
NCI-H838 CTRP2 6.3815 7.6671 5.494 1.7383
PC-14 CTRP2 6.383 8.3723 5.1492 3.1576
NCI-H2444 CTRP2 6.4026 8.0626 5.316 2.6163
NCI-H889 CTRP2 6.4034 9.3247 3.9028 2.9167
NCI-H1395 CTRP2 6.416 8.2835 5.2174 2.8211
Lu-65 CTRP2 6.4179 7.88 5.4161 2.0012
NCI-H1623 CTRP2 6.4293 8.5554 5.0935 3.3127
NCI-H1944 CTRP2 6.4461 9.4867 4.6455 5.149
Calu-1 CTRP2 6.4615 8.3102 5.2375 2.6663
ChaGo-K-1 CTRP2 6.4629 8.5716 5.1103 3.1885
LXF 289 CTRP2 6.471 8.3805 5.21 2.7649
EBC-1 CTRP2 6.4809 8.3143 5.2495 2.5871
MOR/CPR CTRP2 6.4884 9.1081 4.865 4.1638
CAL-12T CTRP2 6.4935 8.4807 5.1772 2.8641
SK-MES-1 CTRP2 6.4937 8.0504 5.3866 2.0086
Calu-6 CTRP2 6.5521 9.0851 4.9236 3.8171
NCI-H1339 CTRP2 6.5542 8.2203 5.3464 2.0835
NCI-H446 CTRP2 6.595 10.9458 3.2644 5.3142
NCI-H2085 CTRP2 6.5978 9.0992 4.1184 1.8489
NCI-H727 CTRP2 6.6153 9.8876 4.5753 5.1567
NCI-H1666 CTRP2 6.6177 9.0712 4.9781 3.4891
NCI-H1734 CTRP2 6.6396 8.2268 5.4004 1.7503
HCC2108 CTRP2 6.6813 9.6911 4.7208 4.4483
HOP-62 CTRP2 6.6868 10.1604 4.4942 5.3758
DMS 454 CTRP2 6.6892 8.8964 5.1134 2.8298
NCI-H661 CTRP2 6.7149 9.2479 4.1173 1.7354
HCC44 CTRP2 6.7289 12.1128 3.5601 9.1667
NCI-H358 CTRP2 6.7337 9.7958 4.7075 4.4203
LUDLU-1 CTRP2 6.7642 9.3254 4.9581 3.3495
HCC1588 CTRP2 6.7651 14.3125 2.4945 13.3536
LOU-NH91 CTRP2 6.7925 10.411 4.4489 5.3925
NCI-H1793 CTRP2 6.8311 10.8288 4.272 6.0604
NCI-H526 CTRP2 6.8416 9.0066 5.1634 2.4175
HOP-92 CTRP2 6.8513 12.0777 3.671 8.5028
NCI-H1915 CTRP2 6.8607 8.6354 5.3495 1.6703
HCC2935 CTRP2 6.8742 8.9421 5.2149 2.1724
HARA [Human squamous cell lung carcinoma] CTRP2 6.8838 10.105 4.6639 4.3687
NCI-H1355 CTRP2 6.9011 9.0497 5.1816 2.268
DMS 114 CTRP2 6.9245 10.244 4.6252 4.4657
NCI-H2291 CTRP2 6.9366 13.2565 3.1522 10.4641
Sq-1 CTRP2 6.9389 13.0151 3.2735 9.9721
SK-LU-1 CTRP2 6.9501 9.3688 5.0628 2.6702
NCI-H292 CTRP2 6.9521 9.2568 5.117 2.4547
NCI-H1435 CTRP2 6.9763 11.3854 4.1051 6.5146
NCI-H1299 CTRP2 7.0569 9.0525 5.2769 1.7164
NCI-H2023 CTRP2 7.0588 9.0634 5.2731 1.7283
NCI-H650 CTRP2 7.0649 10.5953 4.5531 4.5507
Calu-3 CTRP2 7.0766 8.8611 5.3748 1.3382
NCI-H196 CTRP2 7.0799 10.905 4.4136 5.0943
RERF-LC-A1 CTRP2 7.0817 10.2302 4.7401 3.7738
SBC-5 CTRP2 7.0851 10.93 4.4051 5.1209
NCI-H1573 CTRP2 7.1209 11.9372 3.9399 6.9629
HCC1171 CTRP2 7.1223 14.5346 2.6608 12.0831
HCC78 CTRP2 7.151 9.634 5.0666 2.4008
NCI-H1650 CTRP2 7.1531 11.6503 3.2896 4.4534
SW1271 CTRP2 7.1686 9.6672 5.0621 2.3966
COR-L105 CTRP2 7.1804 9.6019 5.0997 2.2397
HCC15 CTRP2 7.2031 13.9036 3.0337 10.4861
Lu-99 CTRP2 7.2373 9.0114 5.3975 1.1059
NCI-H322 CTRP2 7.2447 8.6762 5.5431 0.6384
LC-1/sq-SF CTRP2 7.2461 8.8504 5.4711 0.8577
BEN CTRP2 7.3084 8.6957 5.5655 0.5329
RERF-LC-Ad1 CTRP2 7.3154 8.3896 5.6877 0.2334
NCI-H1792 CTRP2 7.3202 9.6314 5.1695 1.8242
NCI-H226 CTRP2 7.3257 8.829 5.5195 0.6517
NCI-H2172 CTRP2 7.3338 9.5462 5.2155 1.6447
NCI-H1651 CTRP2 7.3401 11.6304 4.2436 5.4009
NCI-H647 CTRP2 7.3603 9.6888 5.1669 1.7917
RERF-LC-Ad2 CTRP2 7.3718 9.1156 5.4231 0.9099
HCC1195 CTRP2 7.4123 14.7052 2.7944 11.0782
NCI-H2122 CTRP2 7.5003 10.9342 4.6801 3.4578
NCI-H2126 CTRP2 7.5171 9.1475 5.4808 0.6365
HCC95 CTRP2 7.5539 10.3051 5.0017 2.1857
NCI-H2009 CTRP2 7.5773 14.6033 2.9655 10.1459
SHP-77 CTRP2 7.5854 9.3754 5.4205 0.7623
HCC366 CTRP2 7.6398 9.7969 5.2717 1.1757
NCI-H1869 CTRP2 7.7341 12.3072 4.1844 5.0905
NCI-H2228 CTRP2 7.7454 11.4644 4.5867 3.5168
NCI-H2170 CTRP2 7.7494 11.3888 4.6241 3.3701
NCI-H441 CTRP2 7.8735 14.7194 3.1205 9.0836
NCI-H2405 CTRP2 7.8975 10.0845 5.28 0.9577
NCI-H1838 CTRP2 7.9121 9.9016 5.361 0.7219
COLO 699 CTRP2 7.931 14.681 3.1794 9.3826
LCLC-103H CTRP2 7.9978 9.3443 5.6071 0.1651
LCLC-97TM1 CTRP2 8.1856 9.9979 5.4425 0.3952
A-549 CTRP2 8.3314 15.4401 3.0887 8.5388
NCI-H2030 CTRP2 8.6125 13.3706 4.2356 3.8412
NCI-H460 CTRP2 8.8223 15.113 3.5631 6.091
HCC1438 CTRP2 8.8297 16.3037 3.0089 8.1573
NCI-H2286 CTRP2 9.0476 18.3893 2.1599 10.954
NCI-H1373 CTRP2 9.4992 15.668 3.7155 4.768
NCI-H841 CTRP2 10.8961 25.7119 -0.0989 15.5213
HCC2279 CTRP2 11.2965 26.3604 -0.1405 15.1182
Hs 888.Lu CTRP2 6.4585 7.9343 5.4183 1.9317
⏷ Show the Full List of 132 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 5.7395 7.1551 5.2182 4.1097
SYO-1 CTRP2 6.6367 8.6564 5.193 2.5842
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.0484 7.9243 5.1078 3.929
TOV-21G CTRP2 5.4343 6.1735 5.3393 4.4031
A2780 CTRP2 5.5151 7.5868 4.7974 6.3611
ONCO-DG-1 CTRP2 5.7012 8.6525 4.4444 7.4183
TYK-nu CTRP2 6.0658 7.4684 5.3502 2.8768
OVSAHO CTRP2 6.212 8.19 5.1079 3.6248
MCAS CTRP2 6.3126 8.5848 4.9902 3.9398
COV362 CTRP2 6.3445 9.7357 4.4425 6.1754
IGROV-1 CTRP2 6.358 8.6737 4.981 3.8999
OAW28 CTRP2 6.4225 9.0565 4.8407 4.3751
DOV13 CTRP2 6.4644 8.2424 5.2727 2.7038
OVCAR-5 CTRP2 6.4921 8.44 5.1961 2.7887
FU-OV-1 CTRP2 6.5294 9.6892 3.812 3.1263
SNU-119 CTRP2 6.5322 10.2107 4.3525 6.2232
OVK18 CTRP2 6.5357 10.7532 4.0858 7.3277
OV-90 CTRP2 6.5398 8.6621 5.1219 3.0194
OC 314 CTRP2 6.5422 8.1725 5.3612 2.0414
TOV-112D CTRP2 6.6278 9.0382 5.0015 3.3778
RMG-I CTRP2 6.6941 12.4996 3.341 10.1229
COV644 CTRP2 6.6955 8.2831 5.41 1.6407
JHOS-2 CTRP2 6.7356 8.0343 5.5494 1.065
ES2 CTRP2 6.7677 8.2443 5.4728 1.4107
HEY A8 CTRP2 6.7997 9.1708 5.0571 2.8987
Caov-3 CTRP2 6.8101 10.8321 4.2548 6.1652
Kuramochi CTRP2 7.1337 11.7984 4.0169 6.6285
EFO-21 CTRP2 7.1799 9.5589 5.1191 2.1668
OVISE CTRP2 7.2034 8.8042 5.4687 0.9667
OVCAR-8 CTRP2 7.2216 10.5739 4.6696 3.8621
OV56 CTRP2 7.2339 8.2502 5.7065 0.2268
EFO-27 CTRP2 7.3477 9.7851 5.1161 1.9893
OV7 CTRP2 7.3574 8.9888 5.469 0.7791
COV434 CTRP2 7.4131 25.7068 -2.6708 26.8152
OAW42 CTRP2 7.5352 8.9625 5.5622 0.4155
OVTOKO CTRP2 7.6579 11.9912 4.2842 4.7995
OVCAR-4 CTRP2 7.8876 19.5666 0.7512 17.4794
SNU-8 CTRP2 8.0117 9.0368 5.7176 0.0455
JHOC-5 CTRP2 8.1833 10.3467 5.3074 0.7075
SNU-840 CTRP2 8.6638 16.3471 2.8786 8.8692
SK-OV-3 CTRP2 9.7267 18.3269 2.6335 8.3741
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.3054 7.6671 5.439 2.0831
Aska-SS CTRP2 6.9848 8.7463 5.3733 1.44
HT-1080 CTRP2 5.7184 6.28 5.605 2.591
KYM-1 CTRP2 5.7261 7.3699 5.1007 4.6269
TE 441.T CTRP2 5.816 6.6738 5.5237 2.6735
Rh41 CTRP2 5.8339 8.7017 4.5365 6.7567
G-401 CTRP2 5.8889 7.8972 4.9854 4.7607
A-204 CTRP2 6.0057 9.5545 4.257 7.587
TTC-709 CTRP2 6.1266 7.4867 5.3905 2.5937
TE 617.T CTRP2 6.2083 8.2166 5.0917 3.6992
G-402 CTRP2 6.2278 8.3156 5.0578 3.8063
Hs 729.T CTRP2 6.2348 8.7994 4.8222 4.7815
RKN CTRP2 6.3356 7.3706 5.6055 1.3526
GCT CTRP2 6.3474 8.3633 5.1268 3.3104
SK-UT-1 CTRP2 6.4304 7.868 5.4308 1.9224
RD CTRP2 6.5351 8.1997 5.3433 2.1238
SK-LMS-1 CTRP2 6.5429 7.764 5.5561 1.2661
Rh18 CTRP2 6.5546 8.295 5.3107 2.2274
Tm87-16 CTRP2 6.7772 10.8224 4.2352 6.2994
BT-12 CTRP2 6.8282 7.9632 5.6326 0.6825
BT-16 CTRP2 7.4948 8.7067 5.6425 0.2559
SW982 CTRP2 7.9776 9.4285 5.5692 0.2294
MES-SA CTRP2 10.1114 27.2384 -1.3841 19.8863
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-MESO-1 CTRP2 5.9554 7.7763 5.1032 4.1315
NCI-H28 CTRP2 6.3349 8.2496 5.1735 3.1368
NCI-H2452 CTRP2 6.8438 10.6629 4.3627 5.6659
JL-1 CTRP2 6.9348 9.3571 5.0584 2.7081
MSTO-211H CTRP2 7.1404 9.6246 4.1755 1.1742
NCI-H2052 CTRP2 8.4983 10.4033 5.4182 0.3311
IST-Mes1 CTRP2 8.7353 17.8387 2.2112 11.2171
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 5.4938 6.2134 5.3902 4.0406
LNCaP clone FGC CTRP2 5.5995 7.8945 4.7267 6.4619
22Rv1 CTRP2 5.7687 8.3618 4.6486 6.8974
DU145 CTRP2 5.919 7.0296 5.4437 2.7778
PaCa-3 CTRP2 7.9003 12.4135 4.2418 4.6507
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 6.5925 8.5298 5.2236 2.5249
YD-15 CTRP2 6.7688 9.0617 5.0884 2.8167
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 CTRP2 4.8115 6.3835 4.5931 8.9966
NUGC-4 CTRP2 5.3067 7.1758 4.7878 6.9027
SNU-16 CTRP2 5.3441 6.2761 5.2063 5.1615
ECC10 CTRP2 5.5165 6.4636 5.3172 4.2569
GSS CTRP2 5.733 7.2925 5.145 4.4275
SNU-1 CTRP2 5.9292 7.2257 5.3552 3.1272
HuG1-N CTRP2 6.1858 8.1217 5.1211 3.6168
SNU-5 CTRP2 6.2279 8.7129 4.8598 4.6363
SNU-620 CTRP2 6.2312 7.354 5.538 1.7938
NUGC-3 CTRP2 6.2903 8.0273 5.2496 2.8951
23132/87 CTRP2 6.3364 8.3961 5.1021 3.4316
SNU-668 CTRP2 6.344 8.7338 4.9406 4.0927
MKN1 CTRP2 6.3741 8.5408 5.0592 3.5467
MKN74 CTRP2 6.4385 8.1434 5.3025 2.4353
SNU-601 CTRP2 6.4517 7.9181 5.4214 1.929
IM95 CTRP2 6.4842 8.2299 5.2929 2.4041
Hs 746.T CTRP2 6.5037 7.9416 5.4459 1.7551
KE-39 CTRP2 6.5945 12.3624 3.3313 10.339
GSU CTRP2 6.8644 7.4525 5.8527 0.0814
SNU-216 CTRP2 6.8783 9.1396 5.1244 2.5228
ECC12 CTRP2 6.8999 8.9475 5.2288 2.0859
MKN7 CTRP2 6.948 11.1643 4.1929 6.1992
AGS CTRP2 6.9833 10.3521 4.6139 4.4239
Fu97 CTRP2 7.085 9.8915 4.0359 1.6802
LMSU CTRP2 7.3931 11.2282 4.472 4.4134
MKN45 CTRP2 7.4569 8.4626 5.7168 0.1363
SH-10-TC CTRP2 7.4765 9.5978 5.2715 1.3152
SNU-719 CTRP2 8.6802 15.7555 3.1706 7.7495
SNU-1077 CTRP2 6.7388 9.98 4.621 4.7684
SNU-685 CTRP2 6.9268 8.5917 5.4093 1.3711
SNG-M CTRP2 7.2843 9.0818 5.3921 1.0822
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP CTRP2 5.5632 7.0717 5.09 5.0485
TT CTRP2 6.3247 17.054 0.7714 20.2389
SW579 CTRP2 6.5034 8.353 5.2467 2.5641
FTC-133 CTRP2 6.5678 9.1594 4.8986 3.8951
8505C CTRP2 6.6679 9.9053 4.6058 4.9446
CGTH-W-1 CTRP2 6.8457 9.2594 5.0457 2.88
ML-1 [Human leukemia] CTRP2 7.4228 9.143 5.4372 0.8274
BHT-101 CTRP2 7.5178 11.526 4.4128 4.4798
CAL-62 CTRP2 7.7059 9.1787 5.5522 0.3596
8305C CTRP2 7.7872 9.3297 5.5291 0.3752
TT2609-C02 CTRP2 7.9006 16.9463 2.0523 13.0671
FTC-238 CTRP2 10.2358 22.3476 1.0656 12.9751
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP2 5.4525 5.941 5.4235 4.0429
FaDu CTRP2 5.5055 5.9452 5.4801 3.6772
SNU-46 CTRP2 5.7136 10.5421 3.5143 11.2728
SNU-1214 CTRP2 5.7772 8.9867 4.345 7.6758
HSC-4 CTRP2 6.0751 7.6133 5.2854 3.1315
PE/CA-PJ15 CTRP2 6.2957 8.2813 5.1279 3.3939
HSC-3 CTRP2 6.2974 8.1198 5.2092 3.2777
YD-10B CTRP2 6.3108 9.26 4.6529 5.3547
PE/CA-PJ34 (clone C12) CTRP2 6.3512 7.777 5.4186 2.0943
SCC-25 CTRP2 6.421 8.0003 5.3598 2.2272
SCC-4 CTRP2 6.4324 8.387 5.1786 2.9553
BICR 22 CTRP2 6.4724 8.1278 5.3342 2.2533
PE/CA-PJ49 CTRP2 6.5609 7.9025 5.5024 1.4527
BICR 16 CTRP2 6.6817 8.5573 5.2712 2.2063
Detroit 562 CTRP2 6.7622 9.2484 4.994 3.2071
CAL-33 CTRP2 6.8053 8.6202 5.322 1.8438
BICR 6 CTRP2 6.8676 8.347 5.4852 1.1577
PE/CA-PJ41 (clone D2) CTRP2 6.8888 9.1779 5.1131 2.553
BHY CTRP2 6.9729 9.3418 5.0904 2.532
BICR 18 CTRP2 7.0428 8.9987 4.3814 0.6397
SNU-1076 CTRP2 7.0529 9.6711 4.9869 2.8339
SCC-9 CTRP2 7.4011 9.8879 5.1009 1.9875
SNU-1041 CTRP2 7.4419 10.3027 4.9365 2.5507
SNU-899 CTRP2 7.4501 15.6804 2.3418 12.7419
SNU-1066 CTRP2 7.4539 10.3322 4.9302 2.5604
BICR 56 CTRP2 7.7862 9.0832 5.62 0.2004
BICR 31 CTRP2 7.8238 9.3193 4.5669 0.0812
YD-8 CTRP2 11.6511 26.1805 -0.6566 12.7531
CAL-27 CTRP2 12.3633 27.1956 0.1566 13.0104
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1197 CTRP2 5.3571 6.6609 5.0679 5.6584
UM-UC-3 CTRP2 5.5102 13.4952 1.8649 18.1801
UM-UC-1 CTRP2 5.7071 6.9172 5.3027 3.836
SCaBER CTRP2 5.9413 6.6461 5.6538 1.8522
JMSU-1 CTRP2 5.9421 8.2199 4.8703 5.1363
5637 CTRP2 6.2411 14.9956 1.7316 17.1744
J82 CTRP2 6.2645 7.635 5.4242 2.2116
RT-4 CTRP2 6.3202 10.1693 4.207 7.2051
KU-19-19 CTRP2 6.5377 7.9231 5.4775 1.5819
BC-3C CTRP2 6.5623 8.2518 5.3368 2.111
U-BLC1 CTRP2 6.6314 10.0914 4.4869 5.497
KMBC-2 CTRP2 6.6507 9.4509 4.8162 4.1035
SW1710 CTRP2 6.6919 9.0912 5.021 3.2011
639V CTRP2 6.8252 9.2117 5.0547 2.8722
TCCSUP CTRP2 6.8683 10.0519 4.6788 4.3314
RT-112 CTRP2 6.8833 8.6159 5.3723 1.5577
HT-1376 CTRP2 7.1292 9.4876 5.1209 2.2198
253J CTRP2 7.4611 9.2382 5.4165 0.8621
BFTC-905 CTRP2 7.6554 8.9043 5.634 0.2162
CAL-29 CTRP2 7.6751 9.0116 5.6023 0.2685
VM-CUB-1 CTRP2 10.1311 20.5878 1.8312 10.6323
T24 CTRP2 10.7912 19.6268 2.6826 6.9796
647V CTRP2 11.9795 23.9179 1.4358 9.712
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.1657 9.2181 5.266 1.6378

References

1 Deubiquitylating enzymes and drug discovery: emerging opportunities. Nat Rev Drug Discov. 2018 Jan;17(1):57-78.
2 Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1157-1170.