Details of the Drug

General Information of Drug (ID: DMJHWYP)

Drug Name
Spautin 1
Synonyms
Spautin-1; 1262888-28-7; 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine; 6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine; CHEMBL2391504; 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine; 4-Quinazolinamine, 6-fluoro-N-[(4-fluorophenyl)methyl]-; Spautin-1 analogue; MBCQ derivative C43; MLS006010730; SCHEMBL1068401; AOB5088; EX-A668; HMS3750O05; HMS3871D13; Spautin-1, >=98% (HPLC); BCP15695; BCP16463; BDBM50069761; MFCD16962292; s7888; ZINC41470892; AKOS016367939; CCG-267171; CS-4616; MCULE-4088585655; SB19056; NCGC00263555-02; NCGC00263555-05; NCGC00263555-07; AK161228; AS-69827; HY-12990; SMR004701692; DS-017062; B5873; FT-0700152; J-690113; Spautin 1 analogue;Spautin1 analogue;N-(4-chlorobenzyl)-6-fluoroquinazoline-4-amine; C43
Indication
Disease Entry ICD 11 Status REF
Inflammation 1A00-CA43.1 Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 271.26
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C15H11F2N3
IUPAC Name
6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine
Canonical SMILES
C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F
InChI
InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChIKey
AWIVHRPYFSSVOG-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
51037431
CAS Number
1262888-28-7
TTD ID
DB0V3R

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ubiquitin carboxyl-terminal hydrolase 10 (USP10) TT5IH09 UBP10_HUMAN Inhibitor [2]
Ubiquitin carboxyl-terminal hydrolase 13 (USP13) TTVJIO2 UBP13_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 1.8388 5.0742 1.6786 28.5601
MEC1 CTRP2 5.872 9.2106 4.3154 7.6066
JM1 CTRP2 5.9861 9.0799 4.4778 6.6982
Peer CTRP2 0.616 2.3092 0.6147 36.1692
MOLM-16 CTRP2 0.7401 3.6454 0.6931 35.4904
EoL-1 CTRP2 1.3604 3.0568 1.3568 31.2176
DEL CTRP2 1.8654 3.1348 1.8646 27.8437
A3/Kawakami CTRP2 1.8833 2.6546 1.8833 27.7218
HEL 92.1.7 CTRP2 1.9114 2.9865 1.9112 27.5352
OCI-AML-5 CTRP2 2.0913 2.9069 2.0912 26.3365
OCI-AML-3 CTRP2 2.0945 3.1511 2.0943 26.3156
BL-70 CTRP2 2.2066 3.9366 2.1947 25.6079
LP-1 CTRP2 2.2785 6.1021 1.9187 26.3313
Ku812 CTRP2 2.3211 6.9372 1.7063 26.9375
Jurkat CTRP2 2.4722 4.8595 2.394 24.0633
KMS-34 CTRP2 2.8362 7.1212 2.1996 23.6355
HEL CTRP2 2.8435 4.3133 2.8324 21.3618
SR CTRP2 2.9728 5.4858 2.8266 20.9659
MM1.S CTRP2 3.045 6.9326 2.4917 21.9558
Daudi CTRP2 3.1383 7.4062 2.4192 21.9512
Ri-1 CTRP2 3.2146 7.4229 2.4945 21.4535
SU-DHL-8 CTRP2 3.2278 6.4352 2.8555 20.0813
RL CTRP2 3.2982 7.0749 2.7141 20.3967
KCL-22 CTRP2 3.3046 6.4655 2.9297 19.581
L-540 CTRP2 3.3292 6.3341 2.9973 19.2602
MOLT-16 CTRP2 3.372 7.103 2.7832 19.9264
KMS-26 CTRP2 3.419 4.7552 3.4029 17.5447
L-1236 CTRP2 3.5479 7.468 2.8322 19.2429
KHM-1B CTRP2 3.6996 6.7461 3.2645 17.1828
LAMA-84 CTRP2 3.7926 8.1089 2.826 18.5939
OCI-Ly3 CTRP2 3.8676 10.5279 1.8041 22.233
KMS-28BM CTRP2 3.8942 7.6548 3.1228 17.1755
SUP-T11 CTRP2 4.0528 7.4408 3.3774 15.7604
AMO1 CTRP2 4.0785 5.7953 3.9614 13.5017
A4/Fukuda CTRP2 4.116 7.584 3.3846 15.5609
SU-DHL-1 CTRP2 4.1388 7.6053 3.3996 15.4409
F-36P CTRP2 4.1604 15.5068 -0.3359 28.0843
NU-DUL-1 CTRP2 4.1612 8.9475 2.8299 17.613
SU-DHL-6 CTRP2 4.1639 7.3194 3.5439 14.8134
TF-1 CTRP2 4.1646 7.9901 3.262 15.9093
JeKo-1 CTRP2 4.1653 8.4056 3.0794 16.624
M-07e CTRP2 4.2172 11.5255 1.664 21.8546
Pfeiffer CTRP2 4.2613 7.1395 3.7192 13.8702
GA-10 CTRP2 4.2745 7.5729 3.5548 14.4717
SU-DHL-4 CTRP2 4.3448 8.3186 3.3005 15.2893
L-363 CTRP2 4.3521 5.8703 4.242 11.6556
U266B1 CTRP2 4.3999 10.4559 2.3533 18.8675
CMK CTRP2 4.4344 7.4664 3.7664 13.2174
EJM CTRP2 4.4405 10.9697 2.1441 19.5613
KYO-1 CTRP2 4.5046 7.3561 3.886 12.5619
KE-97 CTRP2 4.5324 11.1784 2.1294 19.3963
BV-173 CTRP2 4.5457 8.419 3.4568 14.1577
U-937 CTRP2 4.5532 9.4018 3.0043 15.9492
SUP-T1 CTRP2 4.5824 24.4853 -4.421 34.6933
KMS-27 CTRP2 4.5979 7.8301 3.7762 12.7502
ST486 CTRP2 4.6275 9.5262 3.017 15.7192
NCO2 CTRP2 4.6292 7.9631 3.7483 12.7813
P12-Ichikawa CTRP2 4.7028 9.369 3.1645 14.9476
NALM-6 CTRP2 4.7494 9.9929 2.9089 15.8615
HH [Human lymphoma] CTRP2 4.7644 10.3515 2.7492 16.4604
Hs 611.T CTRP2 4.8177 10.0375 2.9518 15.5302
JVM-3 CTRP2 4.8346 7.5658 4.135 10.7138
Ki-JK CTRP2 4.8382 7.9061 3.9845 11.3073
Raji CTRP2 4.8413 8.633 3.6487 12.6572
Mino CTRP2 4.8791 8.6151 3.6938 12.3828
THP-1 CTRP2 5.0084 9.0184 3.6252 12.3566
SUP-M2 CTRP2 5.0128 8.4284 3.9122 11.1735
TALL-1 [Human adult T-ALL] CTRP2 5.0181 9.0176 3.6349 12.2944
NCI-H929 CTRP2 5.0264 6.5369 4.7686 7.7207
KMS-18 CTRP2 5.0365 11.5947 2.3902 17.2411
HPB-ALL CTRP2 5.0412 10.3896 2.988 14.8731
MV4-11 CTRP2 5.0423 6.552 4.7799 7.6333
RCH-ACV CTRP2 5.0559 11.6825 2.3644 17.2971
JJN-3 CTRP2 5.0799 10.3605 3.0379 14.5846
697 CTRP2 5.0833 8.6444 3.8767 11.152
MC116 CTRP2 5.1066 8.6144 3.9134 10.9468
NU-DHL-1 CTRP2 5.1641 11.3773 2.613 16.0908
MHH-CALL-4 CTRP2 5.178 7.3425 4.5828 8.0498
OCI-AML-2 CTRP2 5.1851 9.0742 3.7649 11.3759
Reh CTRP2 5.2435 7.6901 4.4861 8.2795
SET-2 CTRP2 5.2658 10.9776 2.9022 14.7191
K-562 CTRP2 5.3255 9.1609 3.8529 10.6969
KM-H2 CTRP2 5.3684 9.6625 3.6451 11.4619
RPMI-8402 CTRP2 5.3697 9.9755 3.4917 12.0922
CML-T1 CTRP2 5.4257 8.9543 4.0464 9.6725
Mono-Mac-1 CTRP2 5.4639 8.254 4.4251 8.0162
KMS-12-BM CTRP2 5.4836 10.0861 3.5391 11.6516
MOLT-3 CTRP2 5.5123 8.8041 4.1994 8.8466
RPMI-8226 CTRP2 5.5692 10.1649 3.5759 11.3177
EM-2 CTRP2 5.5717 12.5779 2.3758 16.1362
MOLP-8 CTRP2 5.7181 7.029 5.2594 3.9886
MHH-CALL-3 CTRP2 5.7279 9.3575 4.1172 8.7313
OPM-2 CTRP2 5.9069 9.2222 4.3395 7.4358
Granta-519 CTRP2 5.9201 18.7414 -0.408 24.4427
MOLP-2 CTRP2 5.9271 8.9112 4.5121 6.6704
SUP-HD1 CTRP2 5.9315 10.0409 3.9513 9.0139
Karpas-422 CTRP2 5.9453 7.0376 5.463 2.642
KMS-20 CTRP2 6.0201 16.111 0.9908 20.1399
OCI-Ly19 CTRP2 6.023 16.0418 1.0279 20.0132
SK-MM-2 CTRP2 6.0314 7.8241 5.1437 3.811
SU-DHL-10 CTRP2 6.063 8.0444 5.0599 4.1025
EB1 CTRP2 6.0884 11.1448 3.5308 10.459
DB CTRP2 6.0903 9.2841 4.4626 6.5604
RPMI-6666 CTRP2 6.2288 7.7487 5.3406 2.6209
MOTN-1 CTRP2 6.2378 9.112 4.6686 5.4203
CA46 CTRP2 6.2978 10.9784 3.7853 9.0069
HD-MY-Z CTRP2 6.3961 13.6227 2.5442 13.8435
RS4;11 CTRP2 6.4254 10.4979 4.1267 7.3518
SIG-M5 CTRP2 6.4548 9.2387 4.775 4.5941
MOLM-6 CTRP2 6.47 10.678 4.072 7.5007
HL-60 CTRP2 6.4702 9.956 4.4311 6.0018
KMM-1 CTRP2 6.518 9.1247 4.8789 4.0575
PF-382 CTRP2 6.5504 10.966 3.9916 7.6943
WSU-DLCL2 CTRP2 6.5907 8.4407 5.2653 2.3585
Kasumi-1 CTRP2 6.6139 8.7937 5.1106 2.9528
PL21 CTRP2 6.6176 13.1401 2.9622 11.7874
P31/FUJ CTRP2 6.6227 8.334 5.3383 2.0196
KMS-11 CTRP2 6.628 8.8028 5.1161 2.9093
OCI-M1 CTRP2 6.6527 9.9897 4.5529 5.1883
P3HR-1 CTRP2 6.7247 10.2637 4.4713 5.4087
L-428 CTRP2 6.7278 13.1211 3.0582 11.2054
EHEB CTRP2 6.7392 10.0327 4.5954 4.8732
HT CTRP2 6.8117 10.344 4.4957 5.1692
Namalwa CTRP2 6.8147 11.2574 4.0487 7.0085
SUP-B15 CTRP2 6.8666 10.8824 4.2718 6.0042
Ci-1 CTRP2 6.8809 7.8985 5.6868 0.4693
DoHH2 CTRP2 6.9399 8.5272 5.446 1.2237
REC-1 CTRP2 7.4808 10.8898 4.6886 3.4494
HuT 78 CTRP2 7.5654 10.9628 4.7076 3.2723
KO52 CTRP2 7.5779 12.6743 3.904 6.4199
ALL-SIL CTRP2 7.5874 16.1389 2.2183 12.9725
OCI-Ly10 CTRP2 7.5902 23.7008 -1.531 24.1229
AML-193 CTRP2 7.6062 16.2889 2.1583 13.162
SEM CTRP2 7.6477 8.8007 5.6684 0.1609
Kasumi-2 CTRP2 7.827 13.3036 3.7714 6.5923
ME1 CTRP2 7.8684 9.6766 5.4303 0.5672
Karpas-620 CTRP2 8.3505 9.69 5.6149 0.0914
HDLM-2 CTRP2 8.515 10.9427 5.221 0.7475
Toledo CTRP2 8.5383 19.1083 1.4562 14.1404
DND-41 CTRP2 8.8981 10.5535 5.5137 0.1124
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 5.6193 10.8727 3.2674 12.4842
TE8 CTRP2 6.9245 8.9681 5.2347 2.0323
KYSE-510 CTRP2 2.6655 4.6486 2.6237 22.6516
EC-GI-10 CTRP2 2.8022 7.8253 1.8993 24.8144
KYSE-150 CTRP2 3.279 5.4857 3.1586 18.8365
KYSE-30 CTRP2 3.8598 8.1161 2.8926 18.1568
KYSE-180 CTRP2 3.8778 5.8227 3.7366 14.9231
KYSE-450 CTRP2 5.005 8.7895 3.7322 11.927
OE21 CTRP2 5.441 8.4486 4.3087 8.5503
TE-9 CTRP2 5.48 10.2065 3.4761 11.9191
KYSE-70 CTRP2 5.8328 10.5252 3.6253 11.3444
TE-11 CTRP2 5.837 10.1828 3.7999 9.835
TE-4 CTRP2 5.8656 9.9477 3.9418 9.1852
TE-6 CTRP2 6.4596 10.5384 4.1334 7.2632
TE-1 CTRP2 6.834 11.3407 4.022 7.0868
TE-14 CTRP2 6.9624 15.0501 2.2818 13.8084
KYSE-410 CTRP2 6.9999 12.0442 3.7988 7.7327
COLO 680N CTRP2 7.023 9.5459 5.0265 2.7172
KYSE-140 CTRP2 7.0739 10.8279 4.4468 4.9684
TE-5 CTRP2 7.1063 14.1674 2.8304 11.4499
KYSE-520 CTRP2 7.22 15.525 2.2446 13.4965
OE33 CTRP2 7.4025 14.4044 2.9352 10.5457
TE-10 CTRP2 7.7329 10.9126 4.8319 2.6132
OE19 CTRP2 8.0269 13.6777 3.7266 6.4916
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.6152 11.6289 3.7125 8.7377
PSN1 CTRP2 2.8797 5.4995 2.7228 21.6231
L3.3 CTRP2 4.0089 7.4932 3.3098 16.141
HuP-T4 CTRP2 4.049 8.3327 2.9931 17.2649
HPAF-II CTRP2 4.3778 8.9726 3.034 16.2629
Panc 03.27 CTRP2 4.8795 10.9441 2.5669 16.9109
SNU-213 CTRP2 5.3138 9.5035 3.6737 11.4636
Capan-1 CTRP2 6.0065 11.2332 3.4184 11.0821
SUIT-2 CTRP2 6.1289 8.3086 4.9819 4.3056
KP-4 CTRP2 6.2964 10.086 4.2296 7.1541
PaTu 8988s CTRP2 6.5112 24.2051 -2.6499 28.3279
SW1990 CTRP2 6.7045 13.7739 2.7151 12.6074
MIA PaCa-2 CTRP2 6.7364 11.4261 3.9062 7.7282
PK-59 CTRP2 6.7448 11.7772 3.7388 8.4048
DAN-G CTRP2 6.8019 9.9746 4.6692 4.4717
SU.86.86 CTRP2 6.9327 10.9162 4.3032 5.7703
QGP-1 CTRP2 6.9411 10.053 4.7293 4.0181
Panc 05.04 CTRP2 6.9603 11.9055 3.8378 8.1957
TCC-Pan2 CTRP2 7.0371 12.4484 2.8423 6.9473
AsPC-1 CTRP2 7.1792 12.8892 3.5155 8.5953
YAPC CTRP2 7.2077 9.7278 5.0583 2.5398
Hs 766T CTRP2 7.2291 11.6075 4.1776 5.8299
SNU-410 CTRP2 7.2529 13.3868 3.3252 9.2426
PaTu 8988t CTRP2 7.2544 9.3525 5.2567 1.5786
HPAC CTRP2 7.2827 10.9631 4.5248 4.355
PaTu 8902 CTRP2 7.4479 9.6112 5.2502 1.4131
BxPC-3 CTRP2 7.5556 11.5092 4.4454 4.3013
PK-45H CTRP2 7.684 14.2681 3.2059 9.0369
Panc 02.03 CTRP2 7.8402 13.7529 3.5647 7.3897
Panc 10.05 CTRP2 7.9827 13.1728 3.9372 5.7282
KP-3 CTRP2 8.1393 10.2616 5.3212 0.6964
HuP-T3 CTRP2 8.1655 9.5614 5.5929 0.1476
Panc 04.03 CTRP2 8.2743 13.755 3.8513 5.6816
KP-2 CTRP2 8.5867 16.1028 2.9436 8.732
Capan-2 CTRP2 8.7297 17.2709 2.4807 10.2492
CFPAC-1 CTRP2 8.7735 23.5638 -0.558 19.8037
Panc 08.13 CTRP2 8.8175 18.4965 1.9506 12.0215
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 8.2075 22.611 -0.5125 20.588
UACC-62 CTRP2 2.1147 3.8388 2.1043 26.2147
WM266-4 CTRP2 2.3503 2.9201 2.3503 24.6105
CJM [Human melanoma] CTRP2 2.3745 3.4027 2.3741 24.4506
HMCB CTRP2 2.8166 6.0263 2.5268 22.5141
RVH-421 CTRP2 2.8777 4.5462 2.8546 21.1744
SK-MEL-28 CTRP2 3.1051 3.9853 3.1046 19.5839
MeWo CTRP2 3.1636 4.6397 3.1454 19.2535
SK-MEL-5 CTRP2 3.3807 5.6168 3.242 18.2235
SK-MEL-30 CTRP2 3.772 4.8476 3.7626 15.1704
SK-MEL-1 CTRP2 3.8472 6.5963 3.476 15.9655
COLO 792 CTRP2 3.9564 9.2431 2.4896 19.4558
WM115 CTRP2 4.1826 8.1693 3.202 16.0974
WM88 CTRP2 4.2294 8.7853 2.9725 16.8798
G-361 CTRP2 4.2367 7.9667 3.3464 15.3887
SK-MEL-31 CTRP2 4.4749 6.2865 4.2598 11.2191
Hs 944.T CTRP2 5.258 10.2996 3.2305 13.4077
COLO 741 CTRP2 5.6756 16.2305 0.6409 21.951
Hs 895.T CTRP2 6.0341 9.4656 4.3252 7.2458
WM983B CTRP2 6.0972 10.6743 3.7733 9.4349
RPMI-7951 CTRP2 6.3352 9.5898 4.5078 5.9187
Hs 852.T CTRP2 6.4203 12.0585 3.3446 10.6007
Malme-3M CTRP2 6.6118 11.4409 3.8032 8.3685
K029AX CTRP2 6.8071 9.8741 4.722 4.2477
IPC-298 CTRP2 6.9381 9.3854 5.0471 2.7483
SK-MEL-2 CTRP2 7.0182 8.48 5.5105 0.9223
Mel JuSo CTRP2 7.0259 8.9897 5.2871 1.7136
Hs 839.T CTRP2 7.2007 8.339 5.6582 0.3519
Hs 936.T CTRP2 7.2037 8.293 5.6774 0.3042
SK-MEL-3 CTRP2 7.2318 10.9568 4.4935 4.5513
MDA-MB-435S CTRP2 7.2729 12.1517 3.9441 6.7105
IGR-1 CTRP2 7.3698 13.5942 3.309 9.1193
Hs 940.T CTRP2 7.3699 15.0674 2.5843 11.9583
Hs 294T CTRP2 7.3882 10.6326 4.7501 3.3275
Hs 688(A).T CTRP2 7.396 8.2724 5.7613 0.0882
A-375 CTRP2 7.4265 9.2677 5.3866 0.9814
COLO 800 CTRP2 7.4346 11.2538 4.4872 4.2971
IGR-37 CTRP2 7.4536 9.466 5.3162 1.1866
A2058 CTRP2 7.4994 8.6348 5.671 0.2001
WM1799 CTRP2 7.5745 9.0407 5.549 0.4276
A101D CTRP2 7.5859 8.8765 5.6163 0.2738
SK-MEL-24 CTRP2 7.6275 13.3934 3.591 7.5968
LOX-IMVI CTRP2 7.8298 12.7154 4.0537 5.4762
WM793 CTRP2 7.8608 12.0374 4.3925 4.1191
IGR-39 CTRP2 7.9641 9.2972 5.6112 0.1673
Mel Ho CTRP2 8.2334 9.7842 5.5395 0.2069
COLO 829 CTRP2 8.3525 9.9768 5.5159 0.2123
HT-144 CTRP2 8.4523 17.2714 2.2889 11.353
UACC-257 CTRP2 9.4011 19.747 1.7484 11.886
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 5.6578 10.3365 3.5682 11.1645
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kelly CTRP2 5.4336 8.2657 4.3911 8.2257
SK-N-BE(2) CTRP2 5.5586 12.339 2.4836 15.747
CHP-212 CTRP2 5.5764 8.0074 4.65 6.8315
NH-6 CTRP2 5.5929 9.9026 3.7272 10.6403
NB1 CTRP2 5.9875 10.2503 3.8939 9.144
SK-N-FI CTRP2 6.3739 9.2718 4.6964 5.0609
CHP-126 CTRP2 6.6686 8.7495 5.1701 2.6308
SK-N-SH CTRP2 6.8946 9.7278 4.8541 3.5807
SK-N-AS CTRP2 7.0042 8.7082 5.4018 1.316
SK-N-DZ CTRP2 7.2333 8.3465 5.6695 0.3085
KP-N-YN CTRP2 7.8201 10.449 5.0866 1.6288
KP-N-SI9s CTRP2 8.6659 13.947 4.0052 4.6278
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 3.9665 10.2014 2.0546 21.0679
SNU-478 CTRP2 4.6303 7.8917 3.7817 12.6453
SNU-245 CTRP2 6.4129 10.4445 4.1434 7.3043
SNU-308 CTRP2 6.5648 12.718 3.1307 11.2064
SNU-1196 CTRP2 7.1772 16.8438 1.5573 16.0468
HuCC-T1 CTRP2 7.983 9.5354 5.5323 0.2934
SNU-869 CTRP2 8.0233 13.4409 3.8368 6.0661
HuH-28 CTRP2 8.2413 9.5983 5.6076 0.1157
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HOS CTRP2 2.3677 3.2361 2.3676 24.4951
MG-63 CTRP2 2.7706 4.5343 2.7439 21.9003
A-673 CTRP2 3.2283 5.6606 3.0668 19.3187
SK-N-MC CTRP2 3.2832 6.3571 2.9401 19.6068
U2OS CTRP2 4.4575 13.2046 1.0688 23.2981
TC71 CTRP2 6.2558 12.6003 2.9409 12.5442
MHH-ES-1 CTRP2 6.2608 9.7956 4.3459 6.7315
SK-ES-1 CTRP2 6.7972 14.5076 2.4226 13.571
Hs 822.T CTRP2 7.0245 7.8417 5.7735 0.1717
SJSA-1 CTRP2 7.3237 11.2289 4.4252 4.6958
G-292 clone A141B1 CTRP2 7.7091 14.4001 3.1595 9.1807
CAL-78 CTRP2 7.8108 10.7701 4.9407 2.1403
SaOS-2 CTRP2 7.8389 14.7525 3.0801 9.2932
SW1353 CTRP2 7.9439 10.75 5.0225 1.7333
Hs 888.T CTRP2 8.1658 9.9848 5.4393 0.4096
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 CTRP2 1.498 4.1228 1.446 30.4623
MDA-MB-453 CTRP2 3.4486 13.0063 0.2188 28.3819
HCC1500 CTRP2 3.4553 7.411 2.7559 19.7916
ZR-75-30 CTRP2 3.5172 8.5463 2.353 21.1373
MDA-MB-157 CTRP2 3.8865 9.8947 2.1193 21.0331
MDA-MB-468 CTRP2 4.4974 8.0779 3.5633 13.8553
BT-20 CTRP2 4.5015 9.0599 3.1153 15.6331
HCC1419 CTRP2 5.465 11.1457 2.9962 13.9119
Hs 578T CTRP2 5.5332 10.4331 3.4107 12.076
MDA-MB-361 CTRP2 5.6365 11.2188 3.1099 13.0916
DU4475 CTRP2 5.9484 9.495 4.2385 7.7771
ZR-75-1 CTRP2 6.0485 9.5151 4.3124 7.8095
HCC1954 CTRP2 6.1225 10.1378 4.0624 8.1783
KPL-1 CTRP2 6.2361 7.6873 5.3767 2.4575
MCF-7 CTRP2 6.2883 9.4933 4.5187 5.9572
HCC202 CTRP2 6.2903 11.4368 3.5503 9.9956
T-47D CTRP2 6.5193 16.2051 1.3542 17.9541
HCC1143 CTRP2 6.6122 11.4524 3.7978 8.3901
HCC1569 CTRP2 6.873 10.1202 4.6489 4.4462
HCC1395 CTRP2 6.962 11.7929 3.8945 7.4022
CAL-148 CTRP2 6.9648 10.0063 4.7682 3.8265
BT-474 CTRP2 6.9658 11.5347 4.0242 6.8637
CAMA-1 CTRP2 6.9707 11.7661 3.914 7.308
EFM-192A CTRP2 7.1288 11.7003 4.0614 6.4548
CAL-51 CTRP2 7.1595 11.6831 4.0917 6.2841
BT-549 CTRP2 7.1853 10.3174 4.7675 3.5231
CAL-120 CTRP2 7.3074 8.8552 5.4998 0.7226
MDA-MB-231 CTRP2 7.4598 12.6757 3.8214 6.9242
CAL-85-1 CTRP2 7.7453 16.7224 2.0481 13.3346
HMC-1-8 CTRP2 7.7475 13.6187 3.5655 7.521
HDQ-P1 CTRP2 7.7921 15.0537 2.9001 10.0629
HCC1806 CTRP2 7.7988 11.4334 4.6337 3.2761
HCC1428 CTRP2 7.9244 17.9044 1.599 14.63
HCC1937 CTRP2 7.9382 12.1115 4.4063 3.9722
JIMT-1 CTRP2 8.1249 17.8471 1.7743 13.6969
HCC38 CTRP2 8.2373 9.8542 5.5159 0.2429
AU565 CTRP2 8.4367 16.3717 2.7129 9.8106
BT 248 CTRP2 4.9051 12.8303 1.6608 20.2414
BT 231 CTRP2 5.2872 10.102 3.3545 12.8364
BT 416 CTRP2 5.509 9.4285 3.8878 10.1506
BT 145 CTRP2 5.6852 11.2704 3.1264 12.9236
BT 245 CTRP2 5.7335 12.0132 2.7971 14.1507
BT 172 CTRP2 6.0295 9.2811 4.4137 6.8829
BT147 CTRP2 6.2982 8.9792 4.7828 4.833
BT 359 CTRP2 6.4971 11.9461 3.4618 9.9804
BT164 CTRP2 6.5442 10.2198 4.3572 6.1826
BT 504 CTRP2 6.6348 8.931 5.0586 3.1335
BT 239 CTRP2 6.6492 9.1102 4.9817 3.4261
BT 112 CTRP2 6.655 10.1262 4.4874 5.4558
BT 330 CTRP2 6.77 10.1922 4.5397 5.0539
BT 422 CTRP2 6.7701 13.2071 3.0484 11.1698
BT 232 CTRP2 6.9187 12.3871 3.5689 8.807
BT 482 CTRP2 7.0008 10.6653 4.4743 4.9655
BT 139 CTRP2 7.1594 10.5553 4.6369 4.0783
BT 444 CTRP2 7.1871 11.4505 4.2243 5.7033
BT 333 CTRP2 7.2578 10.3991 4.7762 3.3929
BT 320 CTRP2 7.2593 8.3836 5.6664 0.3035
BT 216 CTRP2 7.281 9.1047 5.3805 1.1239
BT 286 CTRP2 7.4265 9.2872 5.3784 1.0074
BT 328 CTRP2 7.5184 12.3742 4.0077 6.0909
BT 224 CTRP2 7.657 12.8244 3.886 6.3784
BT 498 CTRP2 7.7292 13.0207 3.8408 6.4554
BT 440 CTRP2 7.7472 9.1597 5.5765 0.2927
BT 179 CTRP2 8.0072 14.3675 3.3832 7.8622
BT 340 CTRP2 8.2143 15.7053 2.8809 9.5003
BT 228 CTRP2 8.265 16.3857 2.5871 10.5334
BT 159 CTRP2 10.0138 21.3181 1.4084 12.1788
BT 187 CTRP2 12.2847 26.3059 0.5216 12.0777
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 6.7917 10.3952 4.456 5.3646
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 CTRP2 1.2658 2.4916 1.2656 31.8362
T98G CTRP2 1.6596 4.6756 1.5515 29.5753
TM-31 CTRP2 1.9174 2.8582 1.9173 27.4949
GB-1 CTRP2 2.0105 3.1201 2.0102 26.8754
SF126 CTRP2 2.1276 4.6096 2.0592 26.3254
Daoy CTRP2 2.2491 4.13 2.229 25.352
8-MG-BA CTRP2 2.4838 3.4711 2.4835 23.7223
42-MG-BA CTRP2 2.6761 4.1328 2.6679 22.4675
U-251MG CTRP2 2.7295 3.6047 2.7293 22.0851
U-87MG ATCC CTRP2 2.8716 4.3943 2.8575 21.1846
KNS-42 CTRP2 3.3044 4.7515 3.2842 18.3219
Becker CTRP2 3.4791 4.5785 3.4732 17.11
D283 Med CTRP2 3.6154 8.0952 2.6474 19.7574
SF295 CTRP2 6.0247 10.1735 3.9634 8.7807
Hs 683 CTRP2 6.2263 8.402 5.0135 3.9944
DBTRG-05MG CTRP2 6.2336 8.4453 4.9977 4.0478
M059K CTRP2 6.7233 8.1352 5.496 1.2773
SF539 CTRP2 6.7614 13.6454 2.8237 12.0784
KNS-60 CTRP2 6.8009 8.6859 5.2883 1.9799
GMS-10 CTRP2 6.8653 8.3403 5.4869 1.154
U-118MG CTRP2 6.9468 9.9378 4.7888 3.7694
GaMG CTRP2 6.9576 9.9764 4.7776 3.7988
SNU-626 CTRP2 6.9794 13.1733 3.226 10.0945
YKG-1 CTRP2 7.024 8.42 5.5394 0.8208
SNU-466 CTRP2 7.0338 8.6156 5.4597 1.0816
YH-13 CTRP2 7.1271 11.494 4.1607 6.0524
SW1088 CTRP2 7.1276 10.0609 4.8512 3.2693
SF268 CTRP2 7.2332 16.4679 1.7872 15.1401
SNU-489 CTRP2 7.3761 9.0313 5.4605 0.791
LN-18 CTRP2 7.3817 11.4662 4.3507 4.9122
KNS-81 CTRP2 7.501 8.7167 5.6413 0.256
SNU-1105 CTRP2 7.5406 8.7714 5.6371 0.2496
KALS-1 CTRP2 7.7003 10.556 4.9734 2.1354
SW1783 CTRP2 7.7041 15.34 2.6967 10.9831
KG-1-C CTRP2 7.7243 9.0957 5.591 0.2726
LN-229 CTRP2 7.7722 9.2563 5.5505 0.3358
CAS-1 CTRP2 7.8978 18.7493 1.1626 16.1436
GOS-3 CTRP2 8.2273 13.0692 4.1416 4.6302
SNB-75 CTRP2 8.2344 15.0577 3.2064 8.2244
DK-MG CTRP2 8.4603 14.9978 3.3855 7.2263
SNU-201 CTRP2 8.6461 16.7213 2.6877 9.6052
SNU-738 CTRP2 8.9653 19.3725 1.6297 12.9113
CCF-STTG1 CTRP2 9.4685 16.9952 3.0914 7.0469
A-172 CTRP2 11.5017 25.4759 0.4133 13.313
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP2 -0.151 2.4559 -0.1637 41.3124
HEC-50B CTRP2 1.4196 3.5063 1.4051 30.8593
HEC-6 CTRP2 2.5725 4.2316 2.5574 23.181
MFE-319 CTRP2 2.955 5.0166 2.8878 20.8097
HEC-251 CTRP2 3.0942 5.9669 2.8456 20.5213
JHUEM-1 CTRP2 3.4984 7.4112 2.8017 19.4975
HEC-108 CTRP2 3.5074 6.0397 3.277 17.7077
HEC-151 CTRP2 4.3799 8.1702 3.4026 14.7945
AN3-CA CTRP2 5.5968 10.0326 3.666 10.8864
HEC-1-A CTRP2 5.663 12.7954 2.346 16.0605
JHUEM-7 CTRP2 5.7417 9.8167 3.9004 9.6091
JHUEM-3 CTRP2 5.9279 13.3224 2.3079 15.6655
HEC-59 CTRP2 5.9828 10.0524 3.9888 8.7563
HEC-1-B CTRP2 6.0422 9.9751 4.0772 8.2701
ESS-1 CTRP2 6.1999 12.3019 3.0443 12.2351
KLE CTRP2 6.6455 10.734 4.1797 6.7489
EN CTRP2 6.8424 11.4781 3.9606 7.3264
MFE-296 CTRP2 6.9217 14.8893 2.3301 13.699
RL95-2 CTRP2 7.0674 10.2546 4.7188 3.8793
EFE-184 CTRP2 7.18 12.3734 3.7692 7.565
JHUEM-2 CTRP2 7.4733 9.1707 5.4504 0.7518
Ishikawa (Heraklio) 02 ER- CTRP2 2.4744 3.6465 2.4731 23.7882
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O CTRP2 1.9177 2.9474 1.9175 27.4934
ACHN CTRP2 3.3388 4.8665 3.3109 18.1189
SNU-1272 CTRP2 4.9001 8.0383 3.9852 11.1506
KMRC-20 CTRP2 5.19 9.5814 3.5216 12.3662
A-498 CTRP2 6.2642 10.2214 4.1361 7.6046
CAL-54 CTRP2 6.456 10.866 3.9675 7.9612
BFTC-909 CTRP2 6.5631 8.5776 5.1797 2.7472
TUHR4TKB CTRP2 6.6579 11.3843 3.867 8.0246
769-P CTRP2 6.7358 11.4751 3.8816 7.8311
KMRC-2 CTRP2 7.2042 9.8783 4.9862 2.6443
OS-RC-2 CTRP2 7.2616 9.5979 5.1503 1.9578
KMRC-3 CTRP2 7.3211 9.7279 5.1265 1.9803
VMRC-RCW CTRP2 7.3526 9.1663 5.3917 1.0254
Caki-2 CTRP2 7.4154 12.2345 4.0041 6.2551
UO-31 CTRP2 7.5292 17.4568 1.5235 15.5512
VMRC-RCZ CTRP2 7.5889 14.8406 2.8577 10.547
TUHR10TKB CTRP2 7.7704 8.8382 5.7006 0.0915
RCC10RGB CTRP2 8.1181 9.63 5.5508 0.2198
KMRC-1 CTRP2 8.6077 13.4888 4.1793 4.0518
Caki-1 CTRP2 10.3815 20.7443 1.918 10.0272
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GP2d CTRP2 0.6164 7.116 -0.2032 38.3232
LS123 CTRP2 1.5969 4.867 1.4541 30.1088
SW620 CTRP2 1.6057 3.8465 1.5798 29.658
RKO CTRP2 2.2457 4.7647 2.1652 25.5797
CCK-81 CTRP2 2.5614 6.3788 2.147 24.6516
COLO205 CTRP2 2.6912 4.7415 2.6412 22.5081
SK-CO-1 CTRP2 3.0482 4.4577 3.0363 20.001
CW-2 CTRP2 3.477 7.0488 2.9159 19.1287
HT-55 CTRP2 3.8604 7.0501 3.3267 16.4888
SNU-407 CTRP2 4.0048 6.9604 3.5151 15.3663
HCT 116 CTRP2 4.1394 9.5302 2.5388 18.7995
LoVo CTRP2 4.291 9.3316 2.7811 17.477
NCI-H747 CTRP2 4.3595 10.1367 2.4673 18.5286
LS180 CTRP2 4.6331 6.5751 4.3325 10.4882
SNU-C1 CTRP2 4.7051 7.6834 3.9507 11.7804
C2BBe1 CTRP2 4.908 13.0331 1.563 20.5799
MDST8 CTRP2 4.9796 6.2849 4.8088 7.7032
SNU-C5 CTRP2 5.018 10.9494 2.6916 16.107
COLO 678 CTRP2 5.1659 12.0407 2.2859 17.3534
COLO 320 CTRP2 5.2301 11.7931 2.4661 16.5191
SNU-61 CTRP2 5.2833 10.5553 3.127 13.7733
SNU-81 CTRP2 5.6642 14.0661 1.7124 18.4067
SNU-1033 CTRP2 5.7725 11.1415 3.2658 12.1759
SW1417 CTRP2 5.889 10.9931 3.4393 11.2279
COLO201 CTRP2 5.97 10.761 3.6239 10.3034
HT115 CTRP2 6.0358 7.6339 5.2424 3.3876
SNU-C4 CTRP2 6.0863 8.3852 4.9088 4.6931
HCC-56 CTRP2 6.0958 9.6181 4.3002 7.232
LS513 CTRP2 6.1472 8.2545 5.0238 4.0955
SNU-C2A CTRP2 6.3812 10.7101 3.9859 8.0185
T84 CTRP2 6.4433 11.7032 3.5401 9.7558
SW48 CTRP2 6.5328 9.3677 4.7702 4.4838
RCM-1 [Human ESC] CTRP2 6.539 9.4159 4.751 4.5535
SW948 CTRP2 6.5648 9.8518 4.5551 5.3243
HCT 15 CTRP2 6.6869 10.736 4.2101 6.553
NCI-H508 CTRP2 6.7425 8.7665 5.212 2.3588
SNU-503 CTRP2 6.7459 8.68 5.2553 2.182
LS1034 CTRP2 6.8961 10.2851 4.5851 4.672
KM12 CTRP2 6.9992 9.9356 4.8255 3.5473
NCI-H716 CTRP2 7.0123 10.3126 4.6532 4.2222
LS411N CTRP2 7.3728 8.8546 5.5315 0.5867
CL-11 CTRP2 7.3736 12.0519 4.0633 6.0782
DLD-1 CTRP2 7.4096 8.4349 5.7086 0.1624
HT-29 CTRP2 7.7074 8.8601 5.6698 0.1439
HCT 8 CTRP2 8.0895 15.9 2.6994 10.375
OUMS-23 CTRP2 10.3508 21.5156 1.5359 11.3246
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PLC/PRF/5 CTRP2 1.8866 3.9663 1.8634 27.7775
HuH-6 CTRP2 2.2975 7.1303 1.6146 27.3257
JHH-2 CTRP2 2.2999 4.8263 2.2146 25.2353
SK-HEP-1 CTRP2 2.8393 3.5515 2.8393 21.3529
SNU-886 CTRP2 2.9421 5.8539 2.1321 12.3426
Hep-G2 CTRP2 3.3759 6.4773 3.0034 20.5126
SNU-398 CTRP2 3.895 7.7567 3.0814 17.333
JHH-4 CTRP2 3.9746 7.7534 3.166 16.7904
JHH-5 CTRP2 4.4818 10.4519 2.4334 18.3625
SNU-878 CTRP2 5.1955 13.9628 1.3573 20.6504
Hep 3B2.1-7 CTRP2 5.6694 10.095 3.6987 10.5988
SNU-449 CTRP2 6.0846 11.2521 3.474 10.7011
JHH-1 CTRP2 6.2937 10.7887 3.8767 8.6339
HuH-1 CTRP2 6.2989 9.9999 4.2745 6.9614
SNU-761 CTRP2 6.6107 11.8059 3.6209 9.1232
HLF CTRP2 6.6405 10.6599 4.2126 6.6206
SNU-423 CTRP2 6.9441 13.5556 3.0097 11.0203
SNU-475 CTRP2 7.4625 11.8662 4.2137 5.3465
JHH-6 CTRP2 7.5898 8.4202 5.7793 0.0418
SNU-387 CTRP2 7.7846 16.1781 2.3445 12.1829
SNU-182 CTRP2 8.812 10.5266 5.4923 0.1477
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L88 CTRP2 -0.0497 13.0724 -3.2916 44.7817
SBC-5 CTRP2 0.2805 5.8228 -0.1868 39.6038
PC-14 CTRP2 1.8737 4.2902 1.8252 27.9488
HCC827 CTRP2 2.0281 4.2791 1.9882 26.8913
Lu-65 CTRP2 2.0828 5.8359 1.7761 27.4424
KNS-62 CTRP2 2.3467 3.5421 2.3455 24.6386
HCC4006 CTRP2 2.4292 5.472 2.2393 24.7368
HCC44 CTRP2 2.4665 4.9744 2.3713 24.16
NCI-H838 CTRP2 2.6131 5.042 2.5182 23.1825
SK-LU-1 CTRP2 2.7654 4.0555 2.761 21.8598
NCI-H1755 CTRP2 2.8269 9.8065 1.0925 27.4812
NCI-H1105 CTRP2 2.9287 5.2872 2.8169 21.1391
NCI-H1385 CTRP2 3.0831 10.3421 1.1118 26.694
SW1573 CTRP2 3.1676 4.9505 3.122 19.3196
RERF-LC-MS CTRP2 3.4876 5.9947 3.2675 17.8023
LCLC-103H CTRP2 3.6133 4.5042 3.6113 16.2031
Calu-6 CTRP2 3.6194 5.7401 3.4744 16.6566
NCI-H1299 CTRP2 3.7267 5.4737 3.6448 15.7206
NCI-H2030 CTRP2 3.8082 6.4369 3.4866 16.0407
EPLC-272H CTRP2 3.8397 7.82 2.9971 17.8082
NCI-H2029 CTRP2 3.8779 8.0485 2.9404 17.9235
COLO 668 CTRP2 4.042 9.8297 2.3029 19.9471
NCI-H1581 CTRP2 4.1404 8.6376 2.95 17.1958
EBC-1 CTRP2 4.1576 7.816 3.3299 15.6623
HCC2935 CTRP2 4.2216 9.0743 2.8319 17.4519
VMRC-LCD CTRP2 4.2531 9.4065 2.7087 17.8544
NCI-H460 CTRP2 4.3761 7.4516 3.7119 13.5864
NCI-H23 CTRP2 4.6233 11.0731 2.2658 18.6669
NCI-H647 CTRP2 4.6488 8.3383 3.5967 13.3392
HCC1195 CTRP2 4.7219 7.1327 4.2067 10.7265
NCI-H1793 CTRP2 4.7302 8.5329 3.5869 13.1773
NCI-H1155 CTRP2 4.8646 9.1787 3.4109 13.5674
Calu-3 CTRP2 4.887 9.9805 3.0446 14.9976
NCI-H2122 CTRP2 4.8951 6.8867 4.4904 9.1544
NCI-H211 CTRP2 4.9308 8.3076 3.8895 11.4627
NCI-H358 CTRP2 5.0118 7.3822 4.397 9.2149
NCI-H661 CTRP2 5.0506 10.2431 3.0686 14.5268
DV-90 CTRP2 5.1206 10.1828 3.1626 13.9889
EKVX CTRP2 5.1627 12.8102 1.9013 18.7981
NCI-H69 CTRP2 5.25 9.5319 3.6013 11.904
NCI-H2110 CTRP2 5.2872 10.0288 3.3906 12.6883
NCI-H1341 CTRP2 5.3001 9.5334 3.6464 11.6067
COR-L279 CTRP2 5.3737 17.2223 -0.1128 24.7742
SHP-77 CTRP2 5.409 10.1271 3.4521 12.1706
RERF-LC-A1 CTRP2 5.422 13.1726 1.9492 18.0595
LC-1/sq-SF CTRP2 5.4749 10.2846 3.4328 12.1088
HCC1833 CTRP2 5.5072 8.5841 4.3031 8.4261
NCI-H2172 CTRP2 5.5326 8.4382 4.3982 7.9749
NCI-H520 CTRP2 5.5499 10.0853 3.5983 11.2656
COR-L105 CTRP2 5.5533 9.5856 3.8495 10.2152
DMS 454 CTRP2 5.5789 11.619 2.8602 14.2187
NCI-H1944 CTRP2 5.61 10.2831 3.553 11.3269
NCI-H322 CTRP2 5.6582 9.6329 3.919 9.7048
Sq-1 CTRP2 5.667 11.406 3.0429 13.3
NCI-H2196 CTRP2 5.7187 8.4512 4.5598 6.8987
COLO 699 CTRP2 5.7475 7.9994 4.8097 5.7929
NCI-H1339 CTRP2 5.762 9.8959 3.8786 9.6588
NCI-H1792 CTRP2 5.8464 8.6236 4.5863 6.5223
DMS 273 CTRP2 5.8978 10.1436 3.8714 9.4147
NCI-H1184 CTRP2 5.91 9.2114 4.3475 7.3957
NCI-H1568 CTRP2 5.9309 10.2185 3.862 9.3883
COR-L95 CTRP2 5.9356 10.6414 3.6546 10.2433
NCI-H1734 CTRP2 5.9501 8.2997 4.8373 5.2589
LXF 289 CTRP2 6.0134 11.914 3.0837 12.4373
NCI-H2106 CTRP2 6.0397 10.187 3.9692 8.7275
NCI-H1395 CTRP2 6.045 11.0693 3.5324 10.536
HCC1588 CTRP2 6.0572 7.874 5.1402 3.7759
NCI-H1666 CTRP2 6.0733 7.9967 5.0923 3.9467
NCI-H1623 CTRP2 6.0878 10.4987 3.8533 9.1194
NCI-H1703 CTRP2 6.1541 10.8946 3.7101 9.5894
DMS 114 CTRP2 6.2023 14.4293 1.9828 16.3397
NCI-H446 CTRP2 6.2151 12.425 2.9952 12.4039
NCI-H1435 CTRP2 6.2167 9.6879 4.3641 6.7366
NCI-H889 CTRP2 6.2756 8.7151 4.8965 4.3969
SK-MES-1 CTRP2 6.292 12.8318 2.8548 12.8194
NCI-H841 CTRP2 6.3543 10.261 4.1884 7.2214
NCI-H1092 CTRP2 6.3742 9.0035 4.8299 4.5027
NCI-H650 CTRP2 6.3967 11.5046 3.6021 9.5849
NCI-H1563 CTRP2 6.3984 11.5991 3.5562 9.7713
NCI-H2286 CTRP2 6.3987 11.0924 3.8092 8.7227
COR-L51 CTRP2 6.4152 8.6556 5.0335 3.5852
HCC1438 CTRP2 6.4352 14.1563 2.3093 14.6711
MOR/CPR CTRP2 6.4468 7.8358 5.4578 1.7886
LUDLU-1 CTRP2 6.4495 11.4766 3.658 9.2577
NCI-H526 CTRP2 6.4824 9.1749 4.8275 4.3295
NCI-H2081 CTRP2 6.526 17.0986 0.9134 19.3994
NCI-H2342 CTRP2 6.5974 12.4887 3.2707 10.5804
NCI-H810 CTRP2 6.6344 12.7579 3.1658 10.9393
HCC15 CTRP2 6.648 11.2929 3.9046 7.8858
NCI-H1651 CTRP2 6.6495 14.7191 2.2004 14.681
NCI-H522 CTRP2 6.6756 12.5354 3.3088 10.2864
T3M-10 CTRP2 6.7391 13.5354 2.861 11.9708
NCI-H2405 CTRP2 6.7441 11.3934 3.9283 7.6238
NCI-H1573 CTRP2 6.7657 10.607 4.3328 5.915
NCI-H1694 CTRP2 6.7873 12.2306 3.5465 9.1216
NCI-H292 CTRP2 6.7878 8.8897 5.1834 2.4104
CAL-12T CTRP2 6.7991 8.8828 5.1942 2.3526
NCI-H1915 CTRP2 6.8513 8.6426 5.3404 1.7162
LK2 CTRP2 6.8615 11.2393 4.0925 6.7514
NCI-H1869 CTRP2 6.8845 10.6627 4.3924 5.4797
NCI-H441 CTRP2 6.9225 12.9325 3.302 9.8851
NCI-H1650 CTRP2 6.9743 13.091 3.2629 9.9548
DMS 79 CTRP2 6.979 8.8885 5.3052 1.6994
NCI-H2126 CTRP2 6.997 12.2056 3.7172 8.0714
SW1271 CTRP2 7.0084 9.9237 4.8374 3.4867
NCI-H196 CTRP2 7.0294 8.593 5.4671 1.06
NCI-H727 CTRP2 7.0438 11.0453 4.3199 5.5302
NCI-H2444 CTRP2 7.0529 11.095 4.3023 5.5883
HCC2108 CTRP2 7.0565 11.3904 4.1608 6.1609
NCI-H1355 CTRP2 7.1012 12.149 3.8217 7.4761
NCI-H2228 CTRP2 7.1215 11.6457 4.0827 6.379
HARA [Human squamous cell lung carcinoma] CTRP2 7.1919 11.2065 4.3458 5.2038
HCC78 CTRP2 7.1948 9.0843 5.3423 1.3351
NCI-H2087 CTRP2 7.275 10.0518 4.9498 2.6976
NCI-H2009 CTRP2 7.2933 13.9381 3.0838 10.1388
HCC95 CTRP2 7.3003 11.3352 4.3584 4.9964
NCI-H1373 CTRP2 7.343 9.8307 5.0927 2.0805
RERF-LC-Ad2 CTRP2 7.3754 15.9457 2.1545 13.5639
NCI-H226 CTRP2 7.3993 11.6104 4.2935 5.1164
RERF-LC-Ad1 CTRP2 7.4121 8.3581 5.7371 0.1172
BEN CTRP2 7.4291 26.591 -3.099 27.5911
HCC366 CTRP2 7.5606 11.1867 4.6003 3.6911
NCI-H2023 CTRP2 7.5675 11.6217 4.4 4.4641
LOU-NH91 CTRP2 7.6165 12.4823 4.0226 5.8919
HOP-92 CTRP2 7.7225 16.6788 2.0527 13.3555
NCI-H2141 CTRP2 7.8044 20.4884 0.2316 19.19
ChaGo-K-1 CTRP2 7.8667 15.8008 2.5889 11.1364
NCI-H1693 CTRP2 7.8734 16.1051 2.4449 11.667
NCI-H2085 CTRP2 7.9234 10.5374 5.1031 1.4851
NCI-H1838 CTRP2 7.9824 9.9144 5.3877 0.6132
HOP-62 CTRP2 8.0028 18.5322 1.3479 15.3555
HCC2279 CTRP2 8.0209 11.2113 4.8628 2.2075
A-549 CTRP2 8.2016 14.0621 3.6593 6.5175
NCI-H2170 CTRP2 8.3261 18.79 1.4586 14.4636
NCI-H2291 CTRP2 8.3739 10.0522 5.4971 0.2355
Lu-99 CTRP2 8.3842 9.8178 5.5832 0.1188
LCLC-97TM1 CTRP2 8.6584 10.7495 5.3547 0.3941
HCC1171 CTRP2 8.6773 10.3838 5.4931 0.1716
Calu-1 CTRP2 11.4234 22.5448 1.7294 9.4123
Hs 888.Lu CTRP2 7.7435 14.2355 3.2639 8.7184
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 4.908 11.572 2.2845 17.9364
H-STS CTRP2 6.3905 7.4596 5.6003 1.2949
SYO-1 CTRP2 6.7893 9.5101 4.8862 3.6047
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.0146 7.508 5.2876 3.2392
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.0992 10.7218 3.7512 9.523
TYK-nu CTRP2 1.5157 3.0978 1.5131 30.1795
TOV-21G CTRP2 2.0898 3.1565 2.0895 26.3472
MCAS CTRP2 2.324 4.5617 2.2726 24.9591
HEY A8 CTRP2 2.4797 4.1161 2.4674 23.7894
ES2 CTRP2 2.5204 3.7257 2.5186 23.4834
OV-90 CTRP2 3.5236 7.5028 2.7927 19.4605
A2780 CTRP2 3.5703 7.6476 2.7845 19.3609
JHOM-1 CTRP2 3.7979 9.5462 2.1922 20.9913
TOV-112D CTRP2 4.1663 8.1566 3.1909 16.1837
OV56 CTRP2 4.6595 7.5213 3.9756 11.8002
DOV13 CTRP2 4.7733 10.0287 2.9142 15.7841
OVK18 CTRP2 5.1238 9.5119 3.4943 12.6276
COV434 CTRP2 5.9333 9.8887 4.0289 8.6859
OC 314 CTRP2 6.1123 13.5963 2.3249 15.234
IGROV-1 CTRP2 6.1252 9.3732 4.4468 6.5605
SNU-840 CTRP2 6.2354 11.8322 3.3081 11.095
EFO-27 CTRP2 6.3329 12.2184 3.1944 11.3752
OVISE CTRP2 6.4435 10.323 4.2279 6.897
FU-OV-1 CTRP2 6.4756 12.0364 3.3997 10.2738
JHOS-2 CTRP2 6.7436 8.9665 5.117 2.7373
Caov-3 CTRP2 6.7927 13.0145 3.1616 10.6758
SNU-8 CTRP2 6.8317 13.3475 3.0264 11.1495
EFO-21 CTRP2 6.93 12.0615 3.7382 8.0958
OAW28 CTRP2 7.0751 9.9792 4.8554 3.3231
OVCAR-8 CTRP2 7.0999 12.0976 3.846 7.379
Kuramochi CTRP2 7.2934 13.2708 3.4119 8.8294
OVCAR-4 CTRP2 7.3535 12.3601 3.8998 6.7678
RMG-I CTRP2 7.3971 15.6984 2.2932 13.0128
SNU-119 CTRP2 7.6204 10.8179 4.8081 2.8271
OVTOKO CTRP2 7.7239 9.5931 5.3976 0.7369
OAW42 CTRP2 7.8387 8.9484 5.6871 0.0951
SK-OV-3 CTRP2 8.0307 12.6689 4.2049 4.6291
ONCO-DG-1 CTRP2 8.1428 13.8926 3.701 6.4346
JHOC-5 CTRP2 8.5903 14.2602 3.8147 5.4285
COV362 CTRP2 8.7553 17.0474 2.6052 9.7564
OVCAR-5 CTRP2 8.9873 18.0938 2.2607 10.6801
COV644 CTRP2 9.9598 26.422 -1.0943 19.4002
OVSAHO CTRP2 10.0008 17.912 2.9938 6.7759
OV7 CTRP2 10.0073 23.8212 0.2027 15.8784
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.1551 8.481 4.9171 4.529
Aska-SS CTRP2 8.0605 10.2636 5.2844 0.8393
HT-1080 CTRP2 2.2864 3.1278 2.2864 25.0362
SK-UT-1 CTRP2 2.5037 5.114 2.3888 23.9803
SK-LMS-1 CTRP2 2.6917 4.4121 2.6704 22.4074
RKN CTRP2 3.6582 7.6111 2.8921 18.7079
TE 617.T CTRP2 4.8233 8.1175 3.8723 11.7962
Rh41 CTRP2 4.9706 8.2807 3.9411 11.1568
KYM-1 CTRP2 5.44 11.8481 2.6247 15.4466
G-401 CTRP2 5.5082 12.0677 2.575 15.4966
G-402 CTRP2 6.5658 11.4098 3.7828 8.5337
TTC-709 CTRP2 6.5723 10.5861 4.1971 6.8014
TE 441.T CTRP2 6.6712 13.4599 2.8451 12.1555
Hs 729.T CTRP2 6.8343 11.6107 3.889 7.6349
MES-SA CTRP2 7.1076 8.533 5.5346 0.767
Tm87-16 CTRP2 7.1936 9.8093 5.0117 2.5595
BT-16 CTRP2 7.523 8.9554 5.5596 0.4277
SW982 CTRP2 7.8271 9.1057 5.6276 0.177
Rh18 CTRP2 8.1256 9.6222 5.5564 0.2089
RD CTRP2 8.8764 16.8266 2.7915 8.9023
GCT CTRP2 9.9176 20.5728 1.6991 11.351
A-204 CTRP2 10.6484 38.3011 -6.4262 28.1617
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-MESO-1 CTRP2 2.499 4.0527 2.4896 23.6514
MSTO-211H CTRP2 2.6808 5.9912 2.388 23.4267
NCI-H28 CTRP2 3.7029 8.7893 2.4376 20.3186
NCI-H2052 CTRP2 5.077 8.6565 3.8649 11.2149
MPP 89 CTRP2 5.4894 8.9608 4.1012 9.3052
IST-Mes1 CTRP2 6.9299 10.6796 4.4169 5.3084
NCI-H2452 CTRP2 7.3235 14.3438 2.9065 10.7876
JL-1 CTRP2 8.2869 12.7611 4.3198 3.8909
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP2 2.9106 6.0251 2.6296 21.858
DU145 CTRP2 3.7782 7.4884 3.0683 17.7031
LNCaP clone FGC CTRP2 4.8231 8.1755 3.8453 11.9056
VCaP CTRP2 5.237 6.2321 5.1057 5.8479
22Rv1 CTRP2 6.1761 8.7594 4.795 5.0031
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 6.6965 9.6088 4.7721 4.2128
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 CTRP2 1.2736 4.0817 1.2139 31.9821
AGS CTRP2 2.4297 3.7076 2.4274 24.0894
SH-10-TC CTRP2 2.5413 10.3071 0.579 29.8797
ECC10 CTRP2 2.611 4.6986 2.5611 23.0423
ECC12 CTRP2 2.9574 4.8138 2.9148 20.7096
GSS CTRP2 3.0648 6.3605 2.7011 21.1319
HGC-27 CTRP2 3.122 7.8685 2.2217 22.7254
MKN45 CTRP2 3.2112 4.4228 3.2047 18.8969
SNU-1 CTRP2 3.5194 8.8064 2.2421 21.5458
MKN7 CTRP2 4.3094 12.814 1.1236 23.4734
SNU-620 CTRP2 4.3397 6.8712 3.9073 12.9317
NUGC-4 CTRP2 5.5628 7.6718 4.8012 6.2359
SNU-216 CTRP2 5.6632 13.8111 1.839 17.9531
MKN74 CTRP2 5.7535 10.3836 3.6279 10.7201
IM95 CTRP2 5.8382 7.9383 4.9205 5.1379
SNU-5 CTRP2 5.9479 10.1727 3.8993 9.1992
GSU CTRP2 6.0175 20.3206 -1.1161 26.0132
KE-39 CTRP2 6.1931 10.4818 3.9483 8.5222
NCC-StC-K140 CTRP2 6.2131 16.4804 0.9663 19.8353
HuG1-N CTRP2 6.3415 11.0231 3.7981 8.8732
23132/87 CTRP2 6.5023 10.3063 4.282 6.5684
SNU-16 CTRP2 6.6324 11.188 3.9447 7.7466
NUGC-3 CTRP2 6.6532 10.2003 4.4494 6.0318
SNU-668 CTRP2 6.7441 10.079 4.5764 4.9441
KATO III CTRP2 6.7684 9.8729 4.6949 4.4183
MKN1 CTRP2 6.856 11.8406 3.7917 7.9991
SNU-601 CTRP2 6.8913 17.9128 0.8003 19.0746
Hs 746.T CTRP2 7.0614 8.9579 5.3226 1.5431
NCI-N87 CTRP2 7.3269 9.8251 5.0858 2.124
SNU-719 CTRP2 7.9025 9.8309 5.3848 0.6646
LMSU CTRP2 12.8264 23.6958 2.0243 7.0557
SNU-1077 CTRP2 6.3163 11.655 3.4624 10.3096
SNU-685 CTRP2 8.742 13.6771 4.1727 3.9306
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C CTRP2 2.615 4.2394 2.6008 22.8946
B-CPAP CTRP2 5.1137 9.9616 3.2648 13.5883
CGTH-W-1 CTRP2 5.7956 9.8488 3.9311 9.3711
FTC-133 CTRP2 5.9274 12.5842 2.6765 14.2364
ML-1 [Human leukemia] CTRP2 5.9585 8.8976 4.5456 6.4678
8305C CTRP2 6.076 9.6034 4.2911 7.308
TT CTRP2 6.8151 9.1328 5.0857 2.7625
SW579 CTRP2 6.913 10.5432 4.4713 5.1115
FTC-238 CTRP2 7.0549 9.4194 5.1063 2.366
BHT-101 CTRP2 7.3521 9.5218 5.2366 1.5517
TT2609-C02 CTRP2 9.2821 16.0783 3.4002 6.144
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP2 1.5158 2.7643 1.5154 30.1717
HSC-4 CTRP2 2.1769 3.1322 2.1768 25.7663
HSC-3 CTRP2 2.2077 3.2283 2.2075 25.5612
FaDu CTRP2 2.4204 3.0289 2.4204 24.1433
YD-10B CTRP2 3.9415 6.982 3.4392 15.8331
BICR 22 CTRP2 4.284 7.1115 3.7544 13.6722
BICR 56 CTRP2 4.5117 10.8846 2.2526 18.9816
SNU-1214 CTRP2 5.3698 8.8006 4.0704 9.6971
PE/CA-PJ15 CTRP2 5.7094 10.9579 3.3032 12.1514
SCC-4 CTRP2 5.8523 14.2389 1.786 17.755
PE/CA-PJ34 (clone C12) CTRP2 5.8979 9.0357 4.425 7.0945
Detroit 562 CTRP2 5.9111 8.9082 4.4999 6.7538
CAL-27 CTRP2 6.019 8.6481 4.7213 5.6107
BICR 31 CTRP2 6.394 10.9611 3.871 8.4742
SNU-1076 CTRP2 6.4022 11.5007 3.6084 9.5488
BHY CTRP2 6.4459 9.6307 4.5739 5.4479
CAL-33 CTRP2 6.6469 10.7134 4.191 6.6995
BICR 18 CTRP2 6.674 11.3792 3.8818 7.9355
SNU-46 CTRP2 6.862 9.2318 5.0698 2.7613
SNU-1066 CTRP2 6.864 11.7261 3.8543 7.7283
PE/CA-PJ49 CTRP2 7.0533 10.7225 4.4835 4.8498
SCC-9 CTRP2 7.0728 15.1055 2.3397 13.3958
BICR 16 CTRP2 7.0902 15.9045 1.9565 14.7838
PE/CA-PJ41 (clone D2) CTRP2 7.6479 12.1376 4.2082 5.1125
YD-8 CTRP2 7.8056 9.572 5.4434 0.5677
BICR 6 CTRP2 8.0152 14.225 3.4572 7.5617
SNU-1041 CTRP2 8.0197 11.5508 4.7111 2.7472
SNU-899 CTRP2 9.7803 14.8212 4.2394 2.7345
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 CTRP2 1.2923 2.5446 1.2921 31.6599
VM-CUB-1 CTRP2 2.0493 3.7136 2.0416 26.6416
HT-1197 CTRP2 2.1739 3.5001 2.1719 25.7924
J82 CTRP2 2.2178 4.7578 2.1363 25.7693
KU-19-19 CTRP2 2.3032 3.1079 2.3032 24.9246
U-BLC1 CTRP2 2.9683 6.8012 2.4539 22.3202
SCaBER CTRP2 3.1829 5.0553 3.1256 19.2577
253J CTRP2 3.372 5.1948 3.3083 18.0204
KMBC-2 CTRP2 4.3762 10.4928 2.3129 19.0789
5637 CTRP2 5.1064 8.9882 3.7327 11.6886
HT-1376 CTRP2 5.5079 10.4493 3.3803 12.2546
RT-4 CTRP2 5.5883 10.0818 3.6341 11.0366
JMSU-1 CTRP2 6.5418 12.315 3.3134 10.5069
T24 CTRP2 6.9003 13.954 2.7782 12.0111
647V CTRP2 7.0312 10.7285 4.465 4.9578
RT-112 CTRP2 7.1628 12.0202 3.9296 6.9393
BC-3C CTRP2 7.3139 13.8452 3.1448 9.8633
CAL-29 CTRP2 7.7351 9.4132 5.4744 0.5278
BFTC-905 CTRP2 7.8157 9.4125 5.5096 0.4057
639V CTRP2 7.9881 13.9318 3.5793 7.1218
TCCSUP CTRP2 8.1913 17.9794 1.7578 13.6493
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 5.5235 9.1655 4.031 9.5233

References

1 Deubiquitylating enzymes and drug discovery: emerging opportunities. Nat Rev Drug Discov. 2018 Jan;17(1):57-78.
2 Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin. J Cell Mol Med. 2020 Apr;24(7):4324-4340.