Details of the Drug

General Information of Drug (ID: DMJKBWO)

Drug Name
HER2-specific CAR T cell
Indication
Disease Entry ICD 11 Status REF
Atypical teratoid/rhabdoid tumour 2A00.1Y Phase 1 [1]
Choroid plexus carcinoma 2A02.12 Phase 1 [1]
Ependymoma 2A00.0Y Phase 1 [1]
Gastric adenocarcinoma 2B72 Phase 1 [1]
Germ cell tumour 2C80.2 Phase 1 [1]
Glioma 2A00.0 Phase 1 [1]
Medulloblastoma 2A00.10 Phase 1 [1]
Pineoblastoma 2A00.20 Phase 1 [1]
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Drug Type
CAR T Cell Therapy
Cross-matching ID
TTD ID
D0YF6K
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN CAR-T-Cell-Therapy [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Brainstem tissue
The Studied Disease Glioma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Erbb2 tyrosine kinase receptor (HER2) DTT ERBB2 1.98E-01 0.21 1.79
Erbb2 tyrosine kinase receptor (HER2) DTT ERBB2 2.06E-01 -0.15 -0.94
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03500991) HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors