Details of the Drug

General Information of Drug (ID: DMJNV4O)

Drug Name
Tirbanibulin
Synonyms
KX2-391; 897016-82-9; KX-01; UNII-4V9848RS5G; N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide; KX-2-391; CHEMBL571546; 4V9848RS5G; KX2391; KX 01; KX-2391; MLS006011272; SCHEMBL153779; KX01; GTPL7957; DTXSID30237862; MolPort-023-293-512; HUNGUWOZPQBXGX-UHFFFAOYSA-N; HMS3656J15; EX-A2434; BCP02845; ZINC43152787; s2700; BDBM50303801; AKOS027276392; KX2-391; KX-01; SB16619; CS-0248; KX2-391 (KX01); BCP9000828; 2-Pyridineacetamide, 5-(4-(2-(4-morpholinyl)ethoxy)phenyl)-n-(phenylmethyl)-; NCGC00346644-05; NCGC00346644-01; KX 2
Indication
Disease Entry ICD 11 Status REF
Actinic keratosis EK90.0 Approved [1]
Prostate cancer 2C82.0 Phase 2 [2]
ATC Code
D06BX03: Tirbanibulin
D06BX: Other chemotherapeutics
D06B: CHEMOTHERAPEUTICS FOR TOPICAL USE
D06: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D: DERMATOLOGICALS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 431.5
Logarithm of the Partition Coefficient (xlogp) 2.9
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 5.0 +/- 3.9 mcgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 0.34 +/- 0.30 mcg/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 7 h [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 4 hours [4]
Metabolism
The drug is metabolized via the CYP3A4, and to a lesser extent, CYP2C8 [5]
Chemical Identifiers
Formula
C26H29N3O3
IUPAC Name
N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide
Canonical SMILES
C1COCCN1CCOC2=CC=C(C=C2)C3=CN=C(C=C3)CC(=O)NCC4=CC=CC=C4
InChI
InChI=1S/C26H29N3O3/c30-26(28-19-21-4-2-1-3-5-21)18-24-9-6-23(20-27-24)22-7-10-25(11-8-22)32-17-14-29-12-15-31-16-13-29/h1-11,20H,12-19H2,(H,28,30)
InChIKey
HUNGUWOZPQBXGX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
23635314
CAS Number
897016-82-9
UNII
4V9848RS5G
DrugBank ID
DB06137
TTD ID
D02LJW
ACDINA ID
D01489
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tubulin polymerization (TubP) TTHVQ4N NOUNIPROTAC Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Gene/Protein Processing [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 131 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 -5.5119 -4.0248 -5.5119 76.9627
JM1 CTRP2 -6.1132 -3.9648 -6.1132 80.6524
KO52 CTRP2 -9.0554 -5.6284 -9.0556 93.0924
OCI-Ly3 CTRP2 -8.6515 -4.7771 -8.6524 90.7666
DB CTRP2 -8.6073 -4.2441 -8.6098 89.5903
CMK CTRP2 -8.4677 -4.1739 -8.47 89.2191
Pfeiffer CTRP2 -8.4432 1.5384 -8.803 78.4534
EoL-1 CTRP2 -8.3624 -4.7956 -8.3628 90.3096
A4/Fukuda CTRP2 -8.1231 -5.0152 -8.1233 90.2497
SUP-HD1 CTRP2 -7.8316 4.7841 -8.7742 72.7904
Granta-519 CTRP2 -7.6878 0.6443 -7.8854 78.5415
OCI-Ly19 CTRP2 -7.3991 -5.0026 -7.3991 88.0125
HuNS1 CTRP2 -7.0331 -5.1988 -7.0331 86.6004
MJ CTRP2 -6.9767 7.703 -8.6513 67.9575
MOLP-8 CTRP2 -6.9745 0.6213 -7.1309 76.9876
Daudi CTRP2 -6.8284 -4.0958 -6.8285 84.3942
GA-10 CTRP2 -6.7902 -5.6349 -6.7902 85.4506
OCI-AML-3 CTRP2 -6.7864 -5.8664 -6.7864 85.4652
MOTN-1 CTRP2 -6.7423 2.4192 -7.1137 73.6277
BCP-1 CTRP2 -6.7332 -5.165 -6.7332 84.9224
OPM-2 CTRP2 -6.7282 -4.9231 -6.7282 84.7447
Mino CTRP2 -6.687 -5.5592 -6.687 84.7782
ST486 CTRP2 -6.6172 -4.9721 -6.6172 84.1416
Hs 611.T CTRP2 -6.5426 -1.4097 -6.5638 79.2058
SUP-B15 CTRP2 -6.5357 -3.4468 -6.5361 82.2812
OCI-M1 CTRP2 -6.4756 -0.2394 -6.5437 77.0628
EB1 CTRP2 -6.3901 5.0024 -7.2561 69.427
EJM CTRP2 -6.3019 1.3027 -6.4921 74.1192
Kasumi-1 CTRP2 -6.2062 -3.7524 -6.2062 81.0117
SIG-M5 CTRP2 -6.1606 -4.9902 -6.1606 81.2932
K-562 CTRP2 -6.0945 -2.6441 -6.0959 79.3168
RPMI-6666 CTRP2 -5.9829 -4.8898 -5.9829 80.1193
HL-60 CTRP2 -5.9612 -4.3489 -5.9612 79.9025
BL-70 CTRP2 -5.9435 -4.8165 -5.9435 79.8556
NCO2 CTRP2 -5.8277 -3.4135 -5.8277 78.6845
SET-2 CTRP2 -5.6084 -2.8119 -5.6087 77.0478
KE-97 CTRP2 -5.3099 -2.6031 -5.3102 75.2333
KMS-21-BM CTRP2 -5.3067 -3.3326 -5.3067 75.5214
NU-DHL-1 CTRP2 -5.2527 -3.1385 -5.2527 75.1291
SUP-T1 CTRP2 -5.2287 1.6594 -5.3961 70.131
KM-H2 CTRP2 -5.1718 -2.5963 -5.172 74.4236
SEM CTRP2 -5.17 -3.3751 -5.17 74.66
F-36P CTRP2 -5.1335 -2.5483 -5.1336 74.173
LP-1 CTRP2 -5.1212 -2.6905 -5.1213 74.1627
JJN-3 CTRP2 -5.1044 -3.5902 -5.1044 74.2581
JeKo-1 CTRP2 -5.0836 -2.5916 -5.0838 73.8945
KYO-1 CTRP2 -5.0753 -1.0886 -5.0832 72.768
Karpas-422 CTRP2 -5.0251 -1.5847 -5.0277 72.9454
Peer CTRP2 -4.9156 -2.7645 -4.9156 72.9139
Jurkat CTRP2 -4.824 -2.9704 -4.824 72.3656
KMS-26 CTRP2 -4.7917 -3.4372 -4.7917 72.187
L-428 CTRP2 -4.7701 6.052 -5.7598 63.851
DEL CTRP2 -4.7491 -3.363 -4.7491 71.9023
Ci-1 CTRP2 -4.6771 -0.7035 -4.6867 70.3849
EM-2 CTRP2 -4.6322 -1.4038 -4.6343 70.6365
KMS-27 CTRP2 -4.6134 -1.8134 -4.614 70.731
HT CTRP2 -4.5343 -2.5045 -4.5344 70.4265
Kasumi-2 CTRP2 -4.4967 -3.2669 -4.4967 70.2253
P31/FUJ CTRP2 -4.4215 -3.0064 -4.4215 69.7218
HuT 78 CTRP2 -4.4171 -1.392 -4.4185 69.3695
KE-37 CTRP2 -4.2674 -3.5953 -4.2674 68.6986
NALM-6 CTRP2 -4.2561 -3.4085 -4.2561 68.6235
Ku812 CTRP2 -4.2316 -1.832 -4.2318 68.3659
MV4-11 CTRP2 -4.2204 -3.3647 -4.2204 68.3855
U266B1 CTRP2 -4.1625 24.1308 -12.4633 55.0848
M-07e CTRP2 -4.1395 -1.6181 -4.1398 67.7343
NU-DUL-1 CTRP2 -4.1002 -2.9433 -4.1002 67.5844
HEL 92.1.7 CTRP2 -4.0787 -1.1988 -4.0798 67.2378
WSU-DLCL2 CTRP2 -4.0775 -3.3677 -4.0775 67.4334
TF-1 CTRP2 -4.0685 5.8824 -4.9482 61.6352
JVM-2 CTRP2 -4.0238 1.1703 -4.0897 65.4614
LAMA-84 CTRP2 -4.0167 -1.0905 -4.0181 66.8196
RL CTRP2 -4.0165 2.5233 -4.2125 64.2483
KCL-22 CTRP2 -4.0127 -2.6326 -4.0127 67.0002
ME1 CTRP2 -3.9605 8.2465 -5.5462 59.6948
KMS-20 CTRP2 -3.9315 -0.1935 -3.9411 65.92
NB4 CTRP2 -3.9139 -3.1795 -3.9139 66.3435
MOLT-13 CTRP2 -3.8257 -0.9295 -3.8271 65.5846
RS4;11 CTRP2 -3.7999 -2.3224 -3.7999 65.582
OCI-AML-5 CTRP2 -3.751 -3.1091 -3.751 65.258
L-540 CTRP2 -3.7351 -1.6535 -3.7351 65.1272
KMS-34 CTRP2 -3.7302 -2.8621 -3.7302 65.1201
RPMI-8402 CTRP2 -3.6874 -1.2 -3.6878 64.7649
MOLT-16 CTRP2 -3.6538 -2.9006 -3.6538 64.6107
Karpas-299 CTRP2 -3.6525 -2.3001 -3.6525 64.6016
THP-1 CTRP2 -3.6424 -2.4783 -3.6424 64.5348
HPB-ALL CTRP2 -3.6053 -2.709 -3.6053 64.2877
HEL CTRP2 -3.6005 -2.3002 -3.6005 64.2552
HDLM-2 CTRP2 -3.5472 1.5099 -3.6174 62.7453
U-937 CTRP2 -3.52 -2.8554 -3.52 63.7197
KMS-12-BM CTRP2 -3.5148 -2.758 -3.5148 63.6846
SKM-1 CTRP2 -3.4729 -2.9641 -3.4729 63.4055
PF-382 CTRP2 -3.4718 -0.3647 -3.4752 63.218
KMS-18 CTRP2 -3.4677 0.0214 -3.4756 63.0706
KMS-11 CTRP2 -3.4491 -1.9439 -3.4491 63.2459
OCI-AML-2 CTRP2 -3.4216 -2.9722 -3.4216 63.0641
MOLM-6 CTRP2 -3.396 -0.2068 -3.4003 62.7015
RPMI-8226 CTRP2 -3.3887 -2.6519 -3.3887 62.8445
SU-DHL-4 CTRP2 -3.3328 -2.7098 -3.3328 62.4725
RCH-ACV CTRP2 -3.3185 0.3151 -3.33 62.0591
L-363 CTRP2 -3.3067 -2.7814 -3.3067 62.2986
SU-DHL-1 CTRP2 -3.293 1.2198 -3.3361 61.5132
MC116 CTRP2 -3.276 -2.8919 -3.276 62.0937
MM1.S CTRP2 -3.2516 -0.5778 -3.2527 61.8613
CML-T1 CTRP2 -3.1777 -0.554 -3.1787 61.38
Ri-1 CTRP2 -3.1215 1.3968 -3.1686 60.4458
KMS-28BM CTRP2 -3.1094 0.9023 -3.1335 60.5822
OCI-Ly10 CTRP2 -3.0839 1.2015 -3.1197 60.3121
SUP-T11 CTRP2 -3.0296 2.5995 -3.1738 59.3351
SK-MM-2 CTRP2 -2.9085 1.9123 -2.9814 58.994
TALL-1 [Human adult T-ALL] CTRP2 -2.6888 2.6774 -2.8218 57.4312
MOLP-2 CTRP2 -2.6691 0.9464 -2.6855 57.869
Mono-Mac-1 CTRP2 -2.5122 3.6662 -2.7683 56.0796
JURL-MK1 CTRP2 -2.3791 -1.1287 -2.3791 56.1183
P12-Ichikawa CTRP2 -2.3626 -0.8223 -2.3626 56.0084
EHEB CTRP2 -2.3415 3.5108 -2.5609 55.1966
MOLM-13 CTRP2 -2.3324 -0.6614 -2.3324 55.8066
NCI-H929 CTRP2 -2.2735 1.2444 -2.2911 55.312
GDM-1 CTRP2 -2.1559 6.1096 -2.9227 53.5184
HD-MY-Z CTRP2 -2.1013 9.9979 -4.1686 52.5266
MHH-CALL-4 CTRP2 -1.6295 2.3231 -1.6793 51.0904
DND-41 CTRP2 -1.225 8.4634 -2.66 48.9143
AML-193 CTRP2 -1.2017 13.5546 -4.6855 49.1252
NOMO-1 CTRP2 -0.8713 8.076 -2.1412 47.1489
MHH-CALL-3 CTRP2 0.7965 12.512 -2.1795 40.9608
Mono-Mac-6 CTRP2 1.6121 15.5387 -2.7618 39.2732
L-1236 CTRP2 2.4421 19.3373 -3.8 38.4283
REC-1 CTRP2 4.7393 12.8252 1.5131 21.1404
P3HR-1 CTRP2 5.6993 16.4057 0.5734 22.1086
KMM-1 CTRP2 6.7585 19.3528 -0.0244 21.7824
Karpas-620 CTRP2 7.8488 9.1278 5.6279 0.171
⏷ Show the Full List of 131 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 -6.1397 48.3012 -25.9344 54.6718
TE8 CTRP2 -2.4471 5.9704 -3.2025 54.9358
OE21 CTRP2 -6.5397 7.236 -8.032 67.4557
TE-5 CTRP2 -3.6351 9.8068 -5.7416 57.8589
TE-14 CTRP2 -3.3797 -0.973 -3.3801 62.7416
TE-4 CTRP2 -2.9292 -0.2721 -2.9306 59.7335
TE-9 CTRP2 -2.7583 -0.5499 -2.7587 58.6323
KYSE-180 CTRP2 -2.4752 1.5349 -2.5091 56.5301
TE-11 CTRP2 -2.109 5.3448 -2.6728 53.4633
TE-6 CTRP2 -2.0288 7.0088 -3.0472 52.7316
EC-GI-10 CTRP2 -1.0936 15.685 -5.5198 48.8865
KYSE-70 CTRP2 -0.9842 5.0685 -1.3834 47.2181
KYSE-410 CTRP2 -0.7606 9.8491 -2.6817 46.9662
OE33 CTRP2 -0.3819 20.8823 -7.2319 47.3472
TE-10 CTRP2 0.0606 7.7693 -1.0267 42.0474
TE-1 CTRP2 4.3153 14.3933 0.3539 25.8361
KYSE-510 CTRP2 5.016 14.0553 1.1526 21.7359
KYSE-450 CTRP2 6.9152 18.4541 0.5495 19.81
KYSE-520 CTRP2 7.5388 25.3502 -2.3931 26.0581
OE19 CTRP2 7.6345 18.5031 1.0855 16.8397
KYSE-140 CTRP2 7.6852 20.6847 0.0427 19.9383
KYSE-30 CTRP2 7.7441 16.2859 2.2619 12.5545
COLO 680N CTRP2 8.1 19.6494 0.8698 16.7544
KYSE-150 CTRP2 8.6548 22.9472 -0.3424 19.4146
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.8881 27.6829 -4.08 30.1324
MIA PaCa-2 CTRP2 -4.4284 10.9913 -7.0345 59.5593
QGP-1 CTRP2 -2.7568 4.5582 -3.1994 56.9642
BxPC-3 CTRP2 -2.2238 3.7837 -2.4775 54.4637
KP-4 CTRP2 -1.0077 5.7943 -1.5849 47.4744
Panc 03.27 CTRP2 -0.608 41.6307 -17.557 48.9051
HuP-T4 CTRP2 -0.167 10.2011 -2.1929 44.3197
L3.3 CTRP2 0.3158 9.3125 -1.327 41.4922
PK-45H CTRP2 1.3482 17.098 -3.7577 41.0976
PSN1 CTRP2 1.4428 16.3076 -3.2905 40.361
PaTu 8988t CTRP2 1.5771 9.8166 -0.2033 34.9316
KP-3 CTRP2 1.9785 13.7511 -1.5622 36.4434
YAPC CTRP2 3.2714 10.5795 1.1915 25.9157
SU.86.86 CTRP2 4.1665 16.3247 -0.7339 29.0521
KP-2 CTRP2 4.4954 45.6254 -15.0513 42.2133
PK-59 CTRP2 4.5984 14.5413 0.5379 24.6282
SW1990 CTRP2 4.7589 24.3935 -4.2223 34.0946
HPAC CTRP2 5.617 12.9232 2.2426 16.5505
HuP-T3 CTRP2 6.2527 26.8994 -4.2101 31.3941
SNU-213 CTRP2 6.2637 18.0596 0.2185 22.031
DAN-G CTRP2 6.452 18.1812 0.3122 21.3924
Hs 766T CTRP2 6.9938 18.6995 0.4896 19.848
SNU-410 CTRP2 7.0486 13.9051 2.9163 11.2109
Capan-2 CTRP2 7.3338 13.6118 3.2741 9.3164
Panc 04.03 CTRP2 7.5511 20.7624 -0.0998 20.5711
PaTu 8988s CTRP2 7.7017 35.5435 -7.3478 33.1048
HPAF-II CTRP2 7.7364 15.29 2.7446 10.7487
Panc 08.13 CTRP2 8.1345 19.7968 0.8229 16.846
CFPAC-1 CTRP2 8.2398 9.9316 5.4888 0.2881
PaTu 8902 CTRP2 8.724 17.8735 2.1867 11.3213
AsPC-1 CTRP2 9.3592 28.7258 -2.6663 23.7737
SUIT-2 CTRP2 9.6099 21.2712 1.1585 13.5377
TCC-Pan2 CTRP2 10.3126 22.8268 0.8884 13.4222
Panc 05.04 CTRP2 11.5454 29.5972 -1.5227 18.2941
Panc 02.03 CTRP2 13.8917 30.8002 -0.5656 13.2257
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 7.8875 31.1771 -5.0209 29.9688
HMCB CTRP2 -5.597 11.71 -8.5574 61.9963
A2058 CTRP2 -5.0682 -3.4491 -5.0682 74.0089
CJM [Human melanoma] CTRP2 -4.6447 -1.6483 -4.6457 70.8414
IGR-37 CTRP2 -3.0726 2.282 -3.1855 59.7339
WM88 CTRP2 -2.2181 19.782 -8.5191 51.8066
RPMI-7951 CTRP2 -1.9618 2.6619 -2.0535 53.1532
LOX-IMVI CTRP2 -1.6015 5.5133 -2.161 50.7699
G-361 CTRP2 -1.5447 3.469 -1.7031 50.5197
Mel JuSo CTRP2 -1.1587 3.2216 -1.2635 48.0799
IGR-1 CTRP2 -1.1037 16.2962 -5.8066 48.9505
IGR-39 CTRP2 -0.6885 194.6433 -93.9229 49.783
SK-MEL-5 CTRP2 -0.5602 7.3619 -1.5619 45.3409
MDA-MB-435S CTRP2 -0.4147 18.1532 -5.9768 47.0971
RVH-421 CTRP2 -0.4044 10.3664 -2.5104 45.4761
Mel Ho CTRP2 -0.3891 7.5263 -1.4308 44.4581
WM983B CTRP2 -0.3709 15.5532 -4.7319 46.5493
Hs 294T CTRP2 -0.3443 38.2408 -15.6453 48.4349
WM1799 CTRP2 -0.2196 6.7685 -1.0023 43.1857
COLO 741 CTRP2 -0.1664 9.7987 -2.031 44.166
A-375 CTRP2 0.0351 7.0765 -0.8221 41.8307
Hs 944.T CTRP2 0.3553 7.4427 -0.5955 40.139
Hs 852.T CTRP2 0.8136 9.9018 -1.0381 39.2254
Hs 936.T CTRP2 1.1468 23.0479 -6.8186 43.7833
K029AX CTRP2 1.229 67.8482 -28.9568 47.7949
COLO 800 CTRP2 2.4605 16.6664 -2.4854 36.6363
COLO 792 CTRP2 3.0172 21.6386 -4.3998 37.8254
MeWo CTRP2 3.2364 20.5687 -3.6728 36.4645
WM793 CTRP2 3.7186 13.6281 0.1746 27.8096
SK-MEL-28 CTRP2 6.0205 6.8644 5.6143 1.8546
SK-MEL-1 CTRP2 6.0936 16.6585 0.7783 20.6721
Hs 940.T CTRP2 6.521 8.7906 5.0454 3.3638
SK-MEL-30 CTRP2 6.7075 17.0521 1.0829 18.5057
HT-144 CTRP2 6.8066 26.8449 -3.7277 29.7068
SK-MEL-3 CTRP2 6.9501 20.3286 -0.3577 22.3452
SK-MEL-2 CTRP2 7.2596 8.1462 5.7549 0.1291
Hs 688(A).T CTRP2 7.3151 8.7209 5.5585 0.548
SK-MEL-31 CTRP2 7.7192 17.5839 1.604 14.9519
IPC-298 CTRP2 7.8869 19.8842 0.5937 17.9678
Hs 934.T CTRP2 8.3781 17.8506 1.9551 12.6643
Malme-3M CTRP2 9.0577 11.4196 5.2672 0.4215
Hs 839.T CTRP2 9.6832 33.7763 -4.9181 27.2669
WM115 CTRP2 10.2684 34.5692 -4.869 26.4122
WT2-iPS CTRP2 10.476 30.2674 -2.6018 22.0713
A101D CTRP2 10.5511 18.959 2.844 6.6895
UACC-257 CTRP2 10.5604 22.158 1.3686 11.5959
UACC-62 CTRP2 10.6491 23.3275 0.8733 13.0265
COLO 829 CTRP2 11.4212 31.94 -2.7422 21.1133
WM266-4 CTRP2 12.3335 32.7755 -2.5125 19.5056
Hs 895.T CTRP2 12.7738 35.1511 -3.3542 20.6653
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 -1.8716 10.6035 -4.1587 51.5843
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-SH CTRP2 -10.7666 14.0112 -14.9598 68.9436
IMR-32 CTRP2 -9.0942 -5.9638 -9.0943 93.8393
SK-N-DZ CTRP2 -8.4392 9.8226 -10.9342 68.7702
NH-6 CTRP2 -7.6186 13.4264 -11.3755 64.859
SK-N-FI CTRP2 -6.6999 -2.6961 -6.7033 81.8394
MHH-NB-11 CTRP2 -4.9421 -2.6266 -4.9422 73.0412
SiMa CTRP2 -4.1478 3.0397 -4.4258 64.349
KP-N-SI9s CTRP2 -4.0092 2.4373 -4.194 64.292
Kelly CTRP2 -3.5209 -2.8695 -3.5209 63.7254
CHP-126 CTRP2 -3.4025 1.75 -3.4846 61.8195
NB1 CTRP2 -3.2858 -2.7775 -3.2858 62.1592
SK-N-BE(2) CTRP2 -0.6339 8.2129 -1.933 45.977
KP-N-YN CTRP2 5.2882 16.1782 0.3343 23.6917
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 -1.4727 5.1626 -1.9364 50.0677
SNU-1079 CTRP2 3.1395 16.365 -1.6996 33.5914
SNU-1196 CTRP2 4.5189 13.6508 0.9055 23.6785
SNU-308 CTRP2 4.7515 14.2499 0.8199 23.4089
HuCC-T1 CTRP2 5.2481 18.4328 -0.8253 26.8735
SNU-245 CTRP2 7.0146 16.2967 1.7027 15.8277
HuH-28 CTRP2 7.9584 11.5129 4.6925 2.8796
SNU-869 CTRP2 9.0161 26.3433 -1.7475 22.3292
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 -6.6853 -4.3513 -6.6853 84.0249
A-673 CTRP2 -6.4059 -5.2711 -6.4059 82.9216
TC71 CTRP2 -5.9302 -4.6679 -5.9302 79.7572
SK-ES-1 CTRP2 -4.8979 -3.6792 -4.8979 72.8971
MHH-ES-1 CTRP2 -4.4287 -2.5429 -4.4287 69.7443
CADO-ES1 CTRP2 -4.3907 0.9982 -4.4593 67.3981
SaOS-2 CTRP2 -3.4058 -1.485 -3.4058 62.9483
G-292 clone A141B1 CTRP2 -1.5508 5.0342 -1.9921 50.5097
HOS CTRP2 -1.4647 7.686 -2.6511 50.0193
U2OS CTRP2 -1.019 5.9908 -1.6496 47.5701
SJSA-1 CTRP2 -0.9349 5.5206 -1.4359 47.0043
SW1353 CTRP2 0.8653 4.7994 0.677 35.0985
Hs 888.T CTRP2 4.1494 16.0658 -0.6216 28.8222
MG-63 CTRP2 5.4024 49.0188 -15.9801 41.5393
CAL-78 CTRP2 6.6347 17.9347 0.5838 20.2274
Hs 822.T CTRP2 8.4624 17.4893 2.1904 11.6947
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 70 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 -6.4919 -3.8962 -6.492 82.6047
CAL-51 CTRP2 -4.4202 6.3442 -5.4592 62.4861
AU565 CTRP2 -3.8926 2.3072 -4.0546 63.8678
Hs 578T CTRP2 -3.5262 5.5933 -4.2806 59.7862
CAL-148 CTRP2 -3.3733 -1.5589 -3.3733 62.7356
HMC-1-8 CTRP2 -2.6259 -1.4034 -2.6259 57.7628
MDA-MB-468 CTRP2 -2.1768 17.6088 -7.483 51.8797
SK-BR-3 CTRP2 -2.021 19.6579 -8.2657 51.3547
HCC1500 CTRP2 -1.6413 8.625 -3.1667 50.8011
JIMT-1 CTRP2 -1.0005 6.3487 -1.7291 47.5235
HCC1954 CTRP2 -0.8971 6.5482 -1.6744 46.987
HCC38 CTRP2 -0.6957 18.3091 -6.3267 47.919
MDA-MB-157 CTRP2 -0.0563 11.133 -2.4613 44.1539
HCC1395 CTRP2 0.0278 9.2581 -1.6122 42.9656
MCF-7 CTRP2 0.426 7.8189 -0.6493 39.9631
EFM-192A CTRP2 0.4992 40.2636 -15.8809 47.3333
HCC1419 CTRP2 1.9111 11.6152 -0.6467 34.8677
ZR-75-30 CTRP2 2.3834 14.2562 -1.4044 35.0176
HCC2218 CTRP2 2.8184 7.7189 1.9579 24.5581
BT-549 CTRP2 4.2035 46.9863 -15.9802 42.8647
ZR-75-1 CTRP2 4.3706 16.9735 -0.8709 28.9034
MDA-MB-453 CTRP2 4.4787 20.0221 -2.2886 31.6046
CAMA-1 CTRP2 4.9791 16.529 -0.1102 25.6181
HCC202 CTRP2 5.3039 23.7975 -3.4566 31.94
MDA-MB-361 CTRP2 6.335 15.7125 1.4503 17.9792
MDA-MB-231 CTRP2 6.5929 22.9918 -1.9766 26.8437
T-47D CTRP2 6.9802 9.9197 4.8202 3.595
CAL-120 CTRP2 7.1812 15.0547 2.448 12.7977
BT-474 CTRP2 7.4752 21.6112 -0.5811 22.0021
CAL-85-1 CTRP2 7.5833 34.2329 -6.7888 32.6582
HCC1143 CTRP2 8.1233 16.2918 2.5328 10.9499
BT-20 CTRP2 8.1727 18.9333 1.2762 15.3187
HCC1937 CTRP2 8.3669 15.3893 3.137 8.3042
Hs 578Bst CTRP2 8.6657 19.1333 1.5349 13.6798
KPL-1 CTRP2 10.1895 25.4133 -0.4409 17.4029
HCC1428 CTRP2 12.9367 32.9411 -2.1845 18.0907
BT 416 CTRP2 -5.1374 -1.4686 -5.1415 73.438
BT 145 CTRP2 -2.8401 3.4117 -3.0803 57.924
BT 245 CTRP2 -1.8012 2.0498 -1.8407 52.2066
BT 239 CTRP2 -0.955 2.6034 -0.9975 46.697
BT 286 CTRP2 0.1138 8.7591 -1.3292 42.269
BT 112 CTRP2 0.5809 67.0016 -29.0989 48.3208
BT164 CTRP2 0.6617 58.338 -24.7133 47.9933
BT 504 CTRP2 1.1651 10.7845 -1.0436 38.0326
BT 330 CTRP2 1.1666 11.8818 -1.5222 38.8393
BT 172 CTRP2 3.2001 14.102 -0.5454 30.9957
BT 179 CTRP2 3.2023 3720.516 -1853.5603 49.9311
BT 231 CTRP2 3.5307 19.3967 -2.8271 34.5962
BT147 CTRP2 3.5879 17.1887 -1.6874 32.4757
BT 271 CTRP2 4.1897 21.2854 -3.172 33.7038
BT 359 CTRP2 4.3026 14.3405 0.3683 25.8246
BT 232 CTRP2 4.6431 14.6639 0.5176 24.5857
BT 422 CTRP2 4.7926 16.4745 -0.2474 26.3985
BT 428 CTRP2 5.195 20.6804 -1.9929 29.5518
BT 248 CTRP2 5.721 15.2678 1.1605 20.1923
BT 333 CTRP2 5.7499 18.8946 -0.6277 25.351
BT 216 CTRP2 6.4198 14.9464 1.9022 16.2139
BT 187 CTRP2 6.9001 8.6439 5.3696 1.5482
BT 228 CTRP2 6.9881 17.2452 1.2097 17.5686
BT 320 CTRP2 7.2717 13.8417 3.1153 10.0493
BT 139 CTRP2 7.3304 10.7152 4.6741 3.6989
BT 340 CTRP2 7.5557 21.3823 -0.4043 21.3955
BT 498 CTRP2 7.6778 27.9821 -3.5947 28.0636
BT 131 CTRP2 7.9135 20.45 0.3338 18.7056
BT 159 CTRP2 8.4498 15.1451 3.3087 7.534
BT 224 CTRP2 8.5088 57.7656 -17.7923 39.1581
BT 440 CTRP2 8.7675 20.475 0.9534 15.4304
BT 482 CTRP2 9.4994 20.7946 1.3122 13.1977
BT 444 CTRP2 11.3078 32.35 -3.0219 21.8173
BT 328 CTRP2 13.0937 28.2525 0.1205 12.2904
⏷ Show the Full List of 70 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 -4.0112 -3.3871 -4.0112 66.9919
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 -5.21 4.3599 -5.8223 66.8702
YH-13 CTRP2 -3.6305 4.065 -4.047 61.2832
Hs 683 CTRP2 -3.4786 6.8039 -4.5653 58.8644
Daoy CTRP2 -3.2128 -1.5636 -3.2128 61.6705
KNS-60 CTRP2 -2.8933 19.7066 -9.1583 53.3306
Becker CTRP2 -2.6311 47.5471 -22.3165 51.2696
SF539 CTRP2 -2.5511 2.3812 -2.6466 56.7511
A-172 CTRP2 -2.5508 5.1575 -3.1094 55.7152
LN-18 CTRP2 -2.2878 0.5122 -2.2915 55.4777
AM-38 CTRP2 -1.9223 1.804 -1.9529 53.0016
DK-MG CTRP2 -1.8686 23.7007 -10.0117 50.8471
TM-31 CTRP2 -1.0081 11.9347 -3.7915 48.3034
GaMG CTRP2 -0.2187 6.5862 -0.946 43.1006
ONS-76 CTRP2 0.4604 7.9046 -0.6426 39.8179
SNU-466 CTRP2 1.4936 8.0775 0.4051 33.672
LN-229 CTRP2 2.1242 9.385 0.549 31.2287
SF268 CTRP2 2.2612 9.8975 0.4718 31.0256
U-118MG CTRP2 2.6149 22.8448 -5.361 39.6517
42-MG-BA CTRP2 2.8219 15.694 -1.6729 34.3474
SW1088 CTRP2 3.4988 24.1061 -5.1867 37.6879
GB-1 CTRP2 3.5217 12.9036 0.338 27.8567
KALS-1 CTRP2 3.6205 31.0598 -8.5366 40.2464
SF126 CTRP2 4.1098 13.3054 0.6979 25.3092
U-251MG CTRP2 4.5356 13.5771 0.957 23.4749
M059K CTRP2 4.955 62.1053 -22.899 43.9062
SNU-489 CTRP2 5.3809 19.6428 -1.3153 27.7403
U-87MG ATCC CTRP2 5.6526 15.9194 0.7768 21.5757
SNU-738 CTRP2 6.1605 18.4971 -0.0854 23.0956
DBTRG-05MG CTRP2 6.3871 20.429 -0.8643 24.6963
T98G CTRP2 6.684 15.9108 1.6336 16.6768
KG-1-C CTRP2 6.9967 9.5984 4.9846 2.9168
SNU-626 CTRP2 7.6414 17.0846 1.7921 14.4237
SNU-1105 CTRP2 7.9205 20.5916 0.2691 18.8848
CAS-1 CTRP2 8.0581 24.6684 -1.6473 23.6095
8-MG-BA CTRP2 8.2431 18.6928 1.4458 14.6383
GMS-10 CTRP2 8.3183 19.6647 1.0239 15.9091
SNB-75 CTRP2 8.7215 19.8111 1.2445 14.5621
SF295 CTRP2 8.915 27.9657 -2.6256 24.3497
SW1783 CTRP2 9.0174 11.0025 5.4015 0.22
NMC-G1 CTRP2 9.085 20.3663 1.232 14.0571
KNS-81 CTRP2 9.475 22.7578 0.3454 16.2258
CCF-STTG1 CTRP2 11.1928 38.8317 -6.2815 27.3053
SNU-201 CTRP2 12.9046 29.9614 -0.7945 14.8863
GOS-3 CTRP2 13.692 44.5426 -7.2634 25.802
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 -8.1517 11.5393 -11.2326 66.9831
JHUEM-1 CTRP2 -5.8497 4.6775 -6.5899 68.3973
AN3-CA CTRP2 -4.7627 22.0129 -12.0863 56.5315
JHUEM-7 CTRP2 -3.9676 17.5159 -9.2607 56.0839
HEC-151 CTRP2 -2.2883 1.5181 -2.3163 55.3653
ESS-1 CTRP2 -2.1108 18.1814 -7.677 51.6684
MFE-319 CTRP2 -2.0035 2.6382 -2.0951 53.4129
HEC-265 CTRP2 -1.5314 0.5278 -1.532 50.471
HEC-50B CTRP2 -0.623 20.9558 -7.5006 47.9666
HEC-59 CTRP2 0.2894 9.7929 -1.5462 41.8934
HEC-108 CTRP2 0.4235 7.4268 -0.5162 39.7195
HEC-251 CTRP2 0.623 8.1075 -0.5407 39.0035
MFE-296 CTRP2 1.4952 8.3774 0.2927 33.9681
HEC-6 CTRP2 2.6903 15.4424 -1.6766 34.6967
HEC-1-A CTRP2 5.3374 19.4972 -1.2799 27.7501
EFE-184 CTRP2 5.4976 17.343 -0.0668 24.3873
JHUEM-3 CTRP2 5.6464 35.7982 -9.1655 37.6218
KLE CTRP2 6.7539 25.5541 -3.1257 28.7733
HEC-1-B CTRP2 8.466 17.8027 2.0407 12.226
EN CTRP2 8.8722 40.5382 -8.9063 33.1412
Ishikawa (Heraklio) 02 ER- CTRP2 -2.4374 -1.8011 -2.4374 56.5066
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O CTRP2 -3.2375 27.4986 -13.1423 53.0975
TUHR4TKB CTRP2 -0.224 8.3354 -1.5351 43.8786
KMRC-3 CTRP2 0.1097 8.9509 -1.4064 42.3887
BFTC-909 CTRP2 1.889 13.2539 -1.419 36.4498
KMRC-1 CTRP2 2.1308 15.9022 -2.4327 37.4175
TUHR10TKB CTRP2 2.2485 12.5437 -0.7333 34.0476
769-P CTRP2 2.4256 9.3534 0.876 29.3394
VMRC-RCW CTRP2 3.6547 14.8417 -0.4759 29.666
ACHN CTRP2 4.3268 17.1354 -0.9903 29.2796
UO-31 CTRP2 5.3054 19.1706 -1.1443 27.5072
KMRC-2 CTRP2 5.5347 7.4881 4.8636 6.0433
VMRC-RCZ CTRP2 5.7473 20.524 -1.4444 27.293
KMRC-20 CTRP2 6.0146 16.9089 0.5873 21.4237
SNU-1272 CTRP2 7.2455 20.2388 -0.0783 21.0476
Caki-2 CTRP2 7.6365 33.9217 -6.5907 32.3557
OS-RC-2 CTRP2 8.1417 18.5043 1.4641 14.7387
TUHR14TKB CTRP2 8.9184 11.0538 5.3458 0.328
A-498 CTRP2 9.3486 22.5877 0.3386 16.4316
Caki-1 CTRP2 10.8187 23.4469 0.9278 12.643
RCC10RGB CTRP2 11.6727 23.6543 1.3707 10.2542
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CL-34 CTRP2 -7.1465 4.8144 -8.0349 71.378
SNU-81 CTRP2 -4.8984 0.3196 -4.9453 70.436
CCK-81 CTRP2 -4.8057 0.7286 -4.8726 69.5658
HCT 15 CTRP2 -3.7917 2.9349 -4.0286 62.8805
GP2d CTRP2 -3.5221 9.4767 -5.4998 57.6514
SNU-C1 CTRP2 -3.4963 3.3956 -3.7825 61.169
LoVo CTRP2 -3.3519 6.3375 -4.2916 58.6442
HCC-56 CTRP2 -3.0522 16.1417 -7.7182 54.284
NCI-H716 CTRP2 -2.6948 8.4042 -4.2278 55.1716
RKO CTRP2 -2.1552 1.8371 -2.1946 54.4772
SNU-175 CTRP2 -2.0976 0.3031 -2.0988 54.2336
SNU-407 CTRP2 -1.7343 2.678 -1.8161 51.7377
SNU-61 CTRP2 -1.712 8.643 -3.2494 51.1082
LS513 CTRP2 -1.43 1.7842 -1.4476 49.798
T84 CTRP2 -1.4135 5.6711 -1.9958 49.7412
LS180 CTRP2 -1.0423 7.9462 -2.2813 47.9813
NCI-H508 CTRP2 -0.7539 5.8776 -1.3299 46.0197
SNU-C2A CTRP2 -0.5682 3.6878 -0.6917 44.304
KM12 CTRP2 -0.565 5.9362 -1.1393 44.9185
SNU-C5 CTRP2 -0.3818 13.2592 -3.7139 46.124
CW-2 CTRP2 -0.3295 10.057 -2.3067 45.0352
MDST8 CTRP2 0.1167 10.3168 -1.9411 43.0101
COLO205 CTRP2 0.3572 5.3788 0.0061 38.8478
SK-CO-1 CTRP2 1.2924 13.0645 -1.9272 39.0633
SW1463 CTRP2 1.4393 6.9383 0.749 32.8787
DLD-1 CTRP2 1.4992 8.7016 0.1705 34.2734
SNU-C4 CTRP2 1.666 8.9145 0.2621 33.481
CL-11 CTRP2 1.9836 12.8401 -1.1335 35.641
C2BBe1 CTRP2 2.0576 12.7646 -1.025 35.2107
LS1034 CTRP2 2.1599 13.8821 -1.4455 35.7178
COLO201 CTRP2 2.8829 11.236 0.5019 29.1177
HT-55 CTRP2 3.6384 11.0777 1.321 24.5057
SW620 CTRP2 3.86 11.0845 1.5332 23.2085
SW948 CTRP2 3.9727 23.3519 -4.3911 35.8403
SW1417 CTRP2 4.1344 19.2268 -2.1991 32.1865
LS123 CTRP2 4.6195 14.3624 0.6455 24.2537
HCT 116 CTRP2 4.647 10.5091 2.5622 17.4697
SW1116 CTRP2 4.6527 15.926 -0.0993 26.3182
LS411N CTRP2 5.2336 10.5763 3.0717 14.1066
SNU-503 CTRP2 5.3196 34.0252 -8.5545 37.626
NCI-H747 CTRP2 5.6665 13.1678 2.163 16.7483
HT-29 CTRP2 5.8593 15.5857 1.1186 20.0468
SNU-1033 CTRP2 5.9061 16.3132 0.7943 20.9991
OUMS-23 CTRP2 6.6284 18.6257 0.2336 21.2871
HCT 8 CTRP2 6.9621 12.3359 3.6268 8.4982
RCM-1 [Human ESC] CTRP2 8.0744 12.3952 4.359 3.9893
COLO 678 CTRP2 10.8267 43.6833 -8.9533 30.8804
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLF CTRP2 -8.0981 26.6013 -17.5272 60.1726
JHH-4 CTRP2 -5.3975 8.899 -7.3242 63.3487
JHH-1 CTRP2 -4.8886 65.4256 -33.1863 52.6632
SNU-423 CTRP2 -3.6441 5.4695 -4.3776 60.3366
JHH-5 CTRP2 -2.886 9.6674 -4.8853 55.4529
JHH-2 CTRP2 -2.0176 18.8557 -7.8924 51.3934
SNU-398 CTRP2 -0.3737 9.3804 -2.0874 45.0264
SNU-886 CTRP2 -0.2896 6.6954 -1.0563 43.5662
SNU-182 CTRP2 -0.1621 8.5661 -1.553 43.6469
Li-7 CTRP2 -0.0832 7.2052 -0.9923 42.5895
HuH-6 CTRP2 0.3027 9.3651 -1.3616 41.5907
SNU-761 CTRP2 3.0602 12.1293 0.2603 29.3065
HuH-1 CTRP2 3.0718 19.7148 -3.4026 36.4733
PLC/PRF/5 CTRP2 3.1853 15.9836 -1.471 33.0368
SK-HEP-1 CTRP2 3.7397 18.3931 -2.1421 32.9704
JHH-6 CTRP2 6.3201 7.9427 5.314 2.5772
SNU-449 CTRP2 6.4474 28.1683 -4.6835 31.7501
Hep-G2 CTRP2 7.5625 20.1481 0.2143 19.655
Hep 3B2.1-7 CTRP2 7.9824 15.8623 2.6419 10.7561
SNU-387 CTRP2 11.6638 43.38 -8.1722 29.1006
SNU-475 CTRP2 13.4881 32.9852 -1.8424 16.7064
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L88 CTRP2 -9.5524 9.4775 -12.0244 70.7464
DV-90 CTRP2 -8.4454 3.9176 -9.2429 74.9941
NCI-H23 CTRP2 -7.9904 -3.8997 -7.9924 87.7396
NCI-H838 CTRP2 -6.8348 7.78 -8.5207 67.5907
NCI-H1703 CTRP2 -6.6845 -4.3935 -6.6845 84.0634
NCI-H522 CTRP2 -6.4873 1.1503 -6.6713 74.8717
COR-L279 CTRP2 -6.3772 4.1999 -7.0562 70.3437
LC-1F CTRP2 -6.0611 1.5474 -6.265 73.0507
NCI-H1341 CTRP2 -5.9582 -3.4348 -5.9583 79.425
DMS 273 CTRP2 -5.7357 4.8266 -6.5006 67.9169
LK2 CTRP2 -5.473 -5.1046 -5.473 76.7302
NCI-H1339 CTRP2 -4.4292 11.3372 -7.1676 59.3895
NCI-H2081 CTRP2 -4.1559 4.6495 -4.74 62.9444
NCI-H520 CTRP2 -4.1034 3.0696 -4.3827 64.1338
NCI-H841 CTRP2 -3.8649 7.8701 -5.3184 59.6038
SBC-5 CTRP2 -3.7269 -2.4953 -3.7269 65.0973
VMRC-LCD CTRP2 -3.642 8.2343 -5.1965 58.6545
HCC44 CTRP2 -3.5866 5.0678 -4.2165 60.3805
SHP-77 CTRP2 -3.5131 -1.5879 -3.5131 63.662
NCI-H524 CTRP2 -3.444 1.7978 -3.5318 62.0107
NCI-H211 CTRP2 -3.3321 -0.6361 -3.3332 62.3888
NCI-H446 CTRP2 -3.321 0.3389 -3.333 62.0655
NCI-H526 CTRP2 -3.3203 -1.6311 -3.3203 62.3855
COLO 668 CTRP2 -3.2324 13.6027 -6.8142 55.3403
RERF-LC-A1 CTRP2 -3.1948 -1.3726 -3.1948 61.5478
NCI-H2110 CTRP2 -3.1143 3.4773 -3.385 59.2815
NCI-H1184 CTRP2 -2.9913 5.7383 -3.7346 57.4758
HCC1438 CTRP2 -2.9219 0.2337 -2.9275 59.6123
DMS 114 CTRP2 -2.7781 0.111 -2.7813 58.7086
Lu-65 CTRP2 -2.6202 4.6535 -3.0713 56.2527
MOR/CPR CTRP2 -2.4502 -1.8467 -2.4502 56.5922
NCI-H1155 CTRP2 -2.2962 -0.4269 -2.2963 55.5646
NCI-H889 CTRP2 -1.9917 5.7059 -2.6355 52.7923
Lu-99 CTRP2 -1.9764 2.6415 -2.0669 53.2457
NCI-H1694 CTRP2 -1.9508 7.4787 -3.111 52.296
NCI-H1734 CTRP2 -1.8278 4.9519 -2.275 52.0501
NCI-H1792 CTRP2 -1.5601 25.6579 -10.6471 50.1947
NCI-H661 CTRP2 -1.371 4.2962 -1.6467 49.464
NCI-H2029 CTRP2 -1.3091 7.5808 -2.4473 49.2636
LCLC-97TM1 CTRP2 -1.2351 11.6013 -3.89 49.1488
NCI-H69 CTRP2 -1.2163 8.4423 -2.6431 48.872
RERF-LC-MS CTRP2 -1.2135 25.2088 -10.0995 49.5021
NCI-H2171 CTRP2 -1.2132 5.528 -1.7412 48.6142
PC-14 CTRP2 -1.1329 8.9254 -2.7284 48.5264
LCLC-103H CTRP2 -1.1025 4.8842 -1.4718 47.8998
HARA [Human squamous cell lung carcinoma] CTRP2 -0.9989 6.4567 -1.7586 47.5321
HCC827 CTRP2 -0.9195 6.5757 -1.707 47.1159
HCC1588 CTRP2 -0.7614 4.8389 -1.092 45.812
NCI-H1581 CTRP2 -0.7265 5.5524 -1.2165 45.7744
NCI-H1944 CTRP2 -0.5694 20.142 -7.0632 47.7549
EBC-1 CTRP2 -0.4038 18.9462 -6.3378 47.1719
HCC366 CTRP2 -0.1802 6.3853 -0.8447 42.7802
NCI-H1623 CTRP2 -0.0774 80.4924 -36.3967 49.0603
NCI-H810 CTRP2 -0.0602 12.5263 -3.0626 44.6523
DMS 53 CTRP2 0.089 4.8449 -0.1711 40.35
LUDLU-1 CTRP2 0.2341 26.3779 -9.2942 46.5579
COLO 699 CTRP2 0.2825 6.2597 -0.3038 39.8496
SK-MES-1 CTRP2 0.2971 20.2645 -6.282 45.4338
HCC95 CTRP2 0.4191 5.7103 -0.0068 38.6355
HCC2279 CTRP2 0.43 6.5273 -0.2211 39.0845
NCI-H2087 CTRP2 0.4422 13.0865 -2.7963 42.779
COR-L95 CTRP2 0.4944 12.3633 -2.4221 42.2265
A-549 CTRP2 0.5925 10.2106 -1.3976 40.5851
NCI-H2122 CTRP2 0.6175 7.7256 -0.4096 38.7602
LOU-NH91 CTRP2 0.6293 10.7099 -1.5681 40.7044
LXF 289 CTRP2 0.6307 8.4237 -0.6494 39.1852
NCI-H1666 CTRP2 1.269 10.1074 -0.6471 36.9242
NCI-H1105 CTRP2 1.2778 18.2108 -4.3569 41.8261
NCI-H2009 CTRP2 1.467 12.6327 -1.5552 37.9494
NCI-H1373 CTRP2 1.5021 9.0363 0.0399 34.5934
NCI-H2106 CTRP2 1.6296 14.2367 -2.1328 38.3638
NCI-H1355 CTRP2 1.7063 21.6806 -5.6293 41.8236
NCI-H650 CTRP2 1.7302 13.7438 -1.8038 37.5665
Calu-3 CTRP2 1.7993 8.7745 0.4594 32.5117
NCI-H1568 CTRP2 1.9678 14.0291 -1.7029 36.7157
NCI-H358 CTRP2 2.0311 16.8628 -2.9888 38.4456
NCI-H1092 CTRP2 2.1411 16.2992 -2.613 37.6505
NCI-H1573 CTRP2 2.1644 16.4995 -2.6868 37.6933
NCI-H2023 CTRP2 2.1761 11.9261 -0.5211 33.7927
LC-1/sq-SF CTRP2 2.2623 19.7793 -4.1833 39.2747
Calu-6 CTRP2 2.2824 9.8582 0.5107 30.8511
NCI-H322 CTRP2 2.4061 30.1536 -9.162 42.6154
DMS 454 CTRP2 2.5064 13.1694 -0.771 33.3913
HCC4006 CTRP2 2.5601 28.8611 -8.3836 41.9359
HCC78 CTRP2 2.6371 12.9684 -0.5486 32.5265
HCC2108 CTRP2 2.8892 15.8649 -1.6919 34.2096
CAL-12T CTRP2 3.0858 11.4978 0.5815 28.3205
NCI-H1299 CTRP2 3.2041 11.8699 0.5232 28.1678
NCI-H1435 CTRP2 3.3157 12.6973 0.2391 28.6756
NCI-H727 CTRP2 3.6528 11.0077 1.3681 24.3096
NCI-H1838 CTRP2 3.857 12.8133 0.7001 25.9315
NCI-H1650 CTRP2 3.8735 20.7969 -3.2109 34.4318
NCI-H226 CTRP2 3.9671 15.0381 -0.2825 28.412
HCC1833 CTRP2 4.1632 12.8502 0.9698 24.3275
NCI-H647 CTRP2 4.175 19.9067 -2.5003 32.6341
NCI-H1395 CTRP2 4.2426 14.5672 0.2018 26.4444
NCI-H292 CTRP2 4.2891 14.4601 0.2971 26.0623
NCI-H460 CTRP2 4.3268 16.2631 -0.5586 28.2535
NCI-H1385 CTRP2 4.4116 8.3354 3.3603 14.8813
NCI-H2170 CTRP2 4.4964 21.4635 -2.9904 32.7803
NCI-H2405 CTRP2 4.774 20.237 -2.1366 30.6979
NCI-H2342 CTRP2 4.8954 18.6188 -1.2242 28.552
ChaGo-K-1 CTRP2 5.2047 41.0656 -12.1708 40.0967
NCI-H1915 CTRP2 5.2904 20.5094 -1.8257 29.0203
NCI-H2228 CTRP2 5.4608 21.3899 -2.1199 29.2723
Sq-1 CTRP2 5.5049 18.7666 -0.7718 26.2092
SK-LU-1 CTRP2 5.5444 15.2824 1.0024 21.0816
NCI-H2030 CTRP2 5.8602 17.4199 0.2024 22.8807
NCI-H2196 CTRP2 6.0218 30.6364 -6.2705 34.4163
DMS 79 CTRP2 6.5989 15.9855 1.5281 17.2053
NCI-H2444 CTRP2 6.6247 9.5371 4.7549 4.3975
SW1271 CTRP2 6.7191 18.813 0.2133 21.1761
NCI-H2126 CTRP2 6.9578 19.4349 0.0943 21.0779
NCI-H1869 CTRP2 7.0638 25.6939 -2.9442 27.9169
NCI-H2172 CTRP2 7.1017 13.4159 3.1984 9.9993
HCC15 CTRP2 7.1625 21.3373 -0.6914 22.8369
RERF-LC-Ad2 CTRP2 7.2114 26.5621 -3.2588 28.2366
IA-LM CTRP2 7.2533 10.4465 4.7509 3.4982
RERF-LC-Ad1 CTRP2 7.2963 8.2424 5.7343 0.1525
BEN CTRP2 7.301 8.5058 5.6373 0.3517
NCI-H2291 CTRP2 7.409 17.4728 1.4238 16.0995
NCI-H196 CTRP2 7.4282 19.4747 0.4447 19.2067
HCC2935 CTRP2 7.475 10.3869 4.9179 2.5824
HOP-62 CTRP2 7.601 9.5747 5.3457 0.9742
KNS-62 CTRP2 7.7157 22.2412 -0.7068 21.9143
HOP-92 CTRP2 7.7287 13.786 3.4715 7.921
EKVX CTRP2 7.866 14.5679 3.1888 8.8287
HCC1195 CTRP2 7.891 35.1729 -7.011 32.4764
COR-L105 CTRP2 7.9231 22.8583 -0.8528 21.9362
NCI-H2286 CTRP2 8.3418 19.6328 1.0568 15.7659
NCI-H1563 CTRP2 8.4729 9.8134 5.6158 0.0752
HCC1171 CTRP2 8.9914 19.6578 1.5097 13.2777
NCI-H2085 CTRP2 9.1757 26.2602 -1.5874 21.7235
NCI-H1755 CTRP2 9.3073 25.7676 -1.2477 20.7256
T3M-10 CTRP2 10.0047 20.982 1.5622 11.6887
Calu-1 CTRP2 10.5165 18.8453 2.8751 6.6203
NCI-H1793 CTRP2 10.8009 25.4348 -0.0305 15.4578
EPLC-272H CTRP2 11.1077 31.0946 -2.5529 21.1295
NCI-H441 CTRP2 12.0405 29.2948 -1.0435 16.5269
Hs 888.Lu CTRP2 9.5318 44.1141 -10.1679 33.4931
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 -6.0213 -4.083 -6.0213 80.1782
SYO-1 CTRP2 -3.1238 4.5767 -3.602 58.6887
P-STS CTRP2 -1.7401 12.4894 -4.7886 50.9719
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -0.8367 11.3289 -3.3594 47.5488
A2780 CTRP2 -8.8563 5.1035 -9.9702 74.1678
TOV-112D CTRP2 -5.5197 1.717 -5.7107 71.0823
OC 314 CTRP2 -3.6645 -0.2473 -3.6705 64.3649
MCAS CTRP2 -2.569 -0.5666 -2.5692 57.3789
OVK18 CTRP2 -1.4975 5.2103 -1.9744 50.2064
COV434 CTRP2 -1.1977 7.5696 -2.3226 48.7116
OVCAR-8 CTRP2 -1.0082 3.5568 -1.1432 47.145
ONCO-DG-1 CTRP2 -0.8763 5.472 -1.3601 46.6491
Caov-3 CTRP2 -0.6835 15.7167 -5.1205 47.5978
OV7 CTRP2 -0.4098 14.6854 -4.3777 46.5208
COV644 CTRP2 -0.0877 12.7394 -3.184 44.8315
ES2 CTRP2 -0.0444 4.7597 -0.299 41.1931
EFO-21 CTRP2 0.3167 9.9538 -1.5824 41.8406
IGROV-1 CTRP2 0.3361 6.2121 -0.2318 39.4801
OAW42 CTRP2 0.4233 11.2414 -2.008 41.9949
TOV-21G CTRP2 0.6959 13.983 -2.9449 42.1342
SNU-8 CTRP2 0.8684 8.5404 -0.4391 37.8925
SNU-119 CTRP2 1.7879 12.1749 -1.0243 36.0157
RMG-I CTRP2 1.9447 15.8237 -2.5745 38.1179
TYK-nu CTRP2 1.954 12.2499 -0.8917 35.2502
COV362 CTRP2 2.2596 22.3193 -5.4285 40.4618
OV-90 CTRP2 2.6365 9.0473 1.2254 27.6061
DOV13 CTRP2 2.8183 12.1616 0.0078 30.6545
OVCAR-4 CTRP2 3.0151 19.0246 -3.1157 36.2066
OAW28 CTRP2 4.1292 18.1962 -1.6931 31.2318
SK-OV-3 CTRP2 4.2915 15.5578 -0.242 27.5321
HEY A8 CTRP2 4.3561 15.1906 -0.0021 26.7401
JHOC-5 CTRP2 4.4264 23.6844 -4.1578 34.6459
OV56 CTRP2 5.07 31.4894 -7.4989 37.1323
OVISE CTRP2 7.0047 14.9377 2.3705 13.3992
OVTOKO CTRP2 7.3444 19.3376 0.4477 19.345
OVSAHO CTRP2 7.7005 12.0108 4.3027 4.6707
OVCAR-5 CTRP2 8.0125 9.802 5.4443 0.4638
FU-OV-1 CTRP2 8.4149 10.1967 5.4608 0.2829
EFO-27 CTRP2 8.8455 20.4354 1.0287 15.0713
SNU-840 CTRP2 9.7759 22.003 0.92 14.0573
Kuramochi CTRP2 10.0869 22.4151 0.9336 13.5865
JHOM-1 CTRP2 11.336 37.6923 -5.6154 26.1925
JHOS-2 CTRP2 12.3315 32.7782 -2.5152 19.5136
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 1.1087 30.9456 -10.7258 45.3992
Yamato-SS CTRP2 11.2921 28.8695 -1.3461 18.2022
Rh41 CTRP2 -3.6686 -1.6069 -3.6687 64.6879
G-401 CTRP2 -3.5946 2.5643 -3.7691 62.2428
SW982 CTRP2 -2.9972 3.3207 -3.2349 58.7801
RD CTRP2 -2.9881 17.7043 -8.3465 53.8457
G-402 CTRP2 -2.3441 24.8251 -11.0066 51.7325
HT-1080 CTRP2 -1.9738 7.4496 -3.1266 52.4048
TTC-709 CTRP2 -1.9562 5.7538 -2.6093 52.6038
TE 617.T CTRP2 -1.8702 22.182 -9.2955 50.9001
RKN CTRP2 -1.0771 4.2497 -1.3214 47.6667
Hs 729.T CTRP2 -0.7804 16.0018 -5.3475 47.9377
BT-16 CTRP2 -0.7804 4.6173 -1.0682 45.88
GCT CTRP2 -0.768 7.2257 -1.7434 46.4304
BT-12 CTRP2 -0.6436 3.8825 -0.7979 44.8407
KYM-1 CTRP2 -0.492 6.2031 -1.1329 44.5727
SK-UT-1 CTRP2 0.0573 11.5623 -2.5248 43.8089
Tm87-16 CTRP2 0.0721 10.3407 -1.9978 43.2361
A-204 CTRP2 1.341 14.8833 -2.7193 39.9806
MES-SA CTRP2 3.7749 19.9635 -2.8865 34.146
TE 441.T CTRP2 5.1339 6.4492 4.9169 6.8539
SK-LMS-1 CTRP2 5.1386 21.0782 -2.2401 30.1476
Rh18 CTRP2 7.0019 8.7516 5.381 1.3937
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 9.1268 26.008 -1.4995 21.5934
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 CTRP2 -3.3042 -0.9757 -3.3046 62.2493
MSTO-211H CTRP2 -0.1004 6.1855 -0.7006 42.2008
NCI-H2452 CTRP2 0.9581 9.6951 -0.8013 38.2911
NCI-H2052 CTRP2 5.7993 19.0922 -0.6849 25.3956
ACC-MESO-1 CTRP2 6.2012 13.0161 2.6883 13.6522
IST-Mes1 CTRP2 6.4287 25.4753 -3.3527 29.7298
JL-1 CTRP2 12.4386 30.0808 -1.1538 16.3151
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 -4.227 4.9463 -4.8854 62.9575
22Rv1 CTRP2 -1.412 3.4505 -1.5593 49.6969
VCaP CTRP2 0.5486 22.7183 -7.2219 45.2526
NCI-H660 CTRP2 2.9087 11.4294 0.4381 29.2279
DU145 CTRP2 3.8663 20.723 -3.1807 34.4016
PaCa-3 CTRP2 9.3621 31.5396 -4.0548 26.3255
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -4.0186 -3.3942 -4.0186 67.041
A-253 CTRP2 4.8093 20.2586 -2.1165 30.5859
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC-StC-K140 CTRP2 -8.78 14.3848 -12.9855 66.0902
SNU-16 CTRP2 -8.7212 -6.1772 -8.7212 93.7957
IM95 CTRP2 -5.2507 -2.7244 -5.2508 74.953
23132/87 CTRP2 -3.1773 0.4635 -3.19 61.1481
ECC12 CTRP2 -2.8427 -1.0765 -2.8427 59.2047
SNU-620 CTRP2 -2.3741 -1.8334 -2.3741 56.0851
GSS CTRP2 -2.0499 0.7433 -2.0542 53.9031
ECC10 CTRP2 -1.6964 4.2553 -1.9907 51.3848
SH-10-TC CTRP2 -1.1711 15.1572 -5.3614 49.1011
HuG1-N CTRP2 0.1094 13.7876 -3.4481 44.3826
HGC-27 CTRP2 0.1483 21.8513 -7.1849 46.1202
NUGC-4 CTRP2 0.6039 9.6391 -1.152 40.1636
NUGC-3 CTRP2 1.1077 10.3324 -0.9101 37.9803
SNU-1 CTRP2 1.5377 21.2552 -5.58 42.1633
LMSU CTRP2 3.5283 29.454 -7.8181 39.9079
MKN74 CTRP2 3.5626 13.7329 -0.0232 28.7437
MKN1 CTRP2 3.8851 17.6488 -1.6428 31.6899
GSU CTRP2 4.3774 15.9882 -0.377 27.6801
SNU-216 CTRP2 5.2152 13.9931 1.3595 20.5993
SNU-719 CTRP2 5.4138 18.2209 -0.577 25.9116
SNU-601 CTRP2 5.5229 17.7555 -0.2512 24.8356
Hs 746.T CTRP2 6.0139 8.9887 4.5467 6.3542
MKN45 CTRP2 6.6867 9.3799 4.8769 3.7978
SNU-668 CTRP2 7.5704 16.5344 2.0105 13.7607
MKN7 CTRP2 7.7242 25.1355 -2.1399 25.2304
KE-39 CTRP2 7.842 16.0166 2.4655 11.6399
AGS CTRP2 8.1968 16.5475 2.4605 11.1072
SNG-M CTRP2 -1.6484 1.9132 -1.6764 51.2266
SNU-685 CTRP2 3.9604 20.668 -3.0693 34.0296
SNU-1077 CTRP2 5.1607 12.7767 1.9162 18.7479
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 -4.8124 9.9287 -7.0529 61.1596
8305C CTRP2 -2.8316 3.621 -3.1045 57.7791
SW579 CTRP2 -2.6576 9.0864 -4.4277 54.817
B-CPAP CTRP2 -2.1622 3.6184 -2.385 54.1585
BHT-101 CTRP2 -1.9324 2.0671 -1.9773 53.0414
CAL-62 CTRP2 -0.4592 7.5611 -1.5185 44.8547
ML-1 [Human leukemia] CTRP2 1.6989 15.3838 -2.604 38.8278
TT CTRP2 2.4432 9.7941 0.7043 29.8042
8505C CTRP2 4.1082 16.8473 -1.0448 29.9068
CGTH-W-1 CTRP2 4.492 17.3007 -0.9247 28.7538
FTC-133 CTRP2 7.273 21.4437 -0.6569 22.5525
TT2609-C02 CTRP2 9.9154 24.9108 -0.3898 17.6529
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 6 CTRP2 -7.9213 20.3178 -14.5482 61.9903
PE/CA-PJ34 (clone C12) CTRP2 -6.212 3.2459 -6.6844 71.1234
PE/CA-PJ49 CTRP2 -5.8788 -2.5829 -5.8799 78.2365
CAL-27 CTRP2 -5.8152 -4.0833 -5.8152 78.9147
BICR 22 CTRP2 -4.3066 11.8877 -7.5953 57.358
YD-10B CTRP2 -3.1965 -2.0661 -3.1965 61.5639
PE/CA-PJ15 CTRP2 -3.1037 17.5216 -8.382 54.1475
CAL-33 CTRP2 -2.2138 4.9542 -2.6954 54.0973
BICR 18 CTRP2 -0.8853 11.64 -3.9328 45.8081
HSC-3 CTRP2 0.3472 7.2381 -0.5358 40.0574
Detroit 562 CTRP2 0.4326 8.4002 -0.853 40.302
SCC-4 CTRP2 0.5663 15.3641 -3.7091 43.2066
SCC-9 CTRP2 1.4454 27.4032 -8.6741 44.0761
SNU-1076 CTRP2 1.6167 9.2456 0.0756 34.1242
SCC-25 CTRP2 2.0684 15.8149 -2.451 37.6105
BICR 16 CTRP2 2.5219 13.6024 -0.9601 33.7516
HSC-2 CTRP2 3.5524 16.1334 -1.2024 31.5771
BHY CTRP2 5.1619 18.1209 -0.7442 26.8581
YD-8 CTRP2 6.6723 16.4851 1.3376 17.7213
HSC-4 CTRP2 6.8497 15.9124 1.7644 15.9075
SNU-899 CTRP2 6.9357 15.9331 1.8217 15.5462
FaDu CTRP2 7.2026 16.5539 1.7209 15.4291
BICR 31 CTRP2 7.3109 27.3189 -4.2649 27.4058
BICR 56 CTRP2 9.0375 33.6274 -5.339 28.7714
SNU-46 CTRP2 9.1257 22.1565 0.3896 16.6138
SNU-1066 CTRP2 9.2607 18.1067 2.437 9.6746
SNU-1041 CTRP2 10.8169 21.2917 1.9358 9.443
PE/CA-PJ41 (clone D2) CTRP2 12.8298 37.1007 -4.2569 22.2453
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V CTRP2 -6.2755 22.0885 -13.6472 58.9749
RT-112 CTRP2 -3.3577 -2.9262 -3.3577 62.638
U-BLC1 CTRP2 -2.6808 0.322 -2.6854 58.0526
SCaBER CTRP2 -1.6951 22.6022 -9.3228 50.5104
VM-CUB-1 CTRP2 -1.3041 11.1522 -3.7781 49.3953
RT-4 CTRP2 -1.2663 9.4807 -3.0791 49.1643
UM-UC-3 CTRP2 -1.2228 4.7532 -1.575 48.6041
JMSU-1 CTRP2 -0.9617 5.9536 -1.577 47.2383
253J CTRP2 -0.757 5.71 -1.2895 45.9959
5637 CTRP2 -0.0677 14.2291 -3.8261 45.1852
BC-3C CTRP2 -0.0253 27.3358 -10.0035 47.2054
SW1710 CTRP2 0.9038 8.548 -0.4041 37.6909
CAL-29 CTRP2 1.4557 10.9529 -0.8169 36.6505
T24 CTRP2 1.5617 16.9762 -3.4936 40.2658
639V CTRP2 2.4586 11.7647 -0.1646 32.1192
253J-BV CTRP2 2.8228 11.2139 0.4521 29.4304
BFTC-905 CTRP2 3.0936 16.4613 -1.7895 33.8728
HT-1376 CTRP2 5.5962 16.3714 0.5028 22.5375
KU-19-19 CTRP2 5.6418 16.0592 0.6977 21.8455
J82 CTRP2 5.9089 19.5089 -0.8011 25.4666
HT-1197 CTRP2 5.9979 9.681 4.1872 7.8949
UM-UC-1 CTRP2 6.1449 28.0041 -4.8518 32.4841
TCCSUP CTRP2 6.8411 18.8754 0.2801 20.7537
KMBC-2 CTRP2 8.6576 19.7585 1.2243 14.7262
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 -4.2072 8.4935 -5.8967 60.3194

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Tirbanibulin 1% ointment 1% Ointment Topical
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7957).
3 Niu L, Yang J, Yan W, Yu Y, Zheng Y, Ye H, Chen Q, Chen L: Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity. J Biol Chem. 2019 Nov 29;294(48):18099-18108. doi: 10.1074/jbc.RA119.010732. Epub 2019 Oct 18.
4 A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol. 2013 Apr;71(4):883-92. doi: 10.1007/s00280-013-2079-z. Epub 2013 Jan 13.
5 FDA Approved Drug Products: KLISYRI (tirbanibulin) ointment, for topical use
6 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.