Details of the Drug

General Information of Drug (ID: DMJS8VQ)

Drug Name
WH-4-023
Synonyms
WH-4-023; 837422-57-8; 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate; KIN001-112; 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)carbamate; SCHEMBL5755186; KIN112; CHEMBL213100; GTPL8068; CHEBI:94644; 2-aminopyrimidine carbamate, 28; KS-00001CWM; BDBM17729; AOB6574; MolPort-035-789-690; HMS3653D15; C32H36N6O4; EX-A1078; BCP10090; s7565; ZINC14965418; 2801AH; AKOS025142111; CS-3292; NCGC00346959-01
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 568.7
Logarithm of the Partition Coefficient (xlogp) 5.9
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C32H36N6O4
IUPAC Name
(2,6-dimethylphenyl) N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamate
Canonical SMILES
CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C
InChI
InChI=1S/C32H36N6O4/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37/h6-16,21H,17-20H2,1-5H3,(H,33,34,35)
InChIKey
NBTNHSGBRGTFJS-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11844351
ChEBI ID
CHEBI:94644
TTD ID
D0Y1SR

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [1]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
LCK tyrosine protein kinase (LCK) DTT LCK 4.46E-02 -0.13 -1.09
Proto-oncogene c-Src (SRC) DTT SRC 7.46E-03 -0.2 -1.24
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 142 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.4049 6.7071 0.9805 7.542
K-562 GDSC1 -8.9151 6.121 -11.1451 73.8006
EM-2 GDSC1 -8.6525 4.1049 -10.1773 76.2421
CTV-1 GDSC1 -7.5688 -5.4966 -7.5688 98.5608
BV-173 GDSC1 -7.4379 6.7483 -9.7867 70.5031
LAMA-84 GDSC1 -7.3512 -3.6824 -7.3612 93.6494
EoL-1 GDSC1 -6.8129 -2.8665 -6.8345 90.712
ALL-SIL GDSC1 -5.894 -1.523 -5.9559 84.6679
DoHH2 GDSC1 -5.8804 -0.3279 -6.0674 80.7392
MY-M12 GDSC1 -4.5048 1.4447 -4.9037 71.2618
SUP-B15 GDSC1 -4.2161 3.8197 -5.2634 65.5359
GA-10 GDSC1 -3.3681 -1.5879 -3.3694 70.9686
KCL-22 GDSC1 -2.4562 -0.3989 -2.4671 59.8402
SU-DHL-6 GDSC1 -2.455 -1.3712 -2.455 60.1296
SU-DHL-4 GDSC1 -1.7284 0.272 -1.7487 51.0308
MEG-01 GDSC1 -1.4483 54.4929 -26.9468 49.8083
NU-DUL-1 GDSC1 -1.1392 1.7836 -1.3188 44.299
Daudi GDSC1 -1.0625 7.7872 -3.553 46.6659
SU-DHL-16 GDSC1 -0.9188 0.9115 -0.9509 41.1033
Karpas-231 GDSC1 -0.6684 3.6087 -1.355 40.6556
PF-382 GDSC1 -0.5864 28.4816 -13.2331 48.0178
Farage GDSC1 -0.4345 2.6298 -0.7683 36.6826
BL-41 GDSC1 -0.1156 13.6852 -5.4804 44.1407
NK-92MI GDSC1 0.9928 6.1283 -0.7591 28.3371
MLMA GDSC1 1.1938 11.2246 -3.0805 35.7637
MC116 GDSC1 1.5021 4.8308 0.3508 19.0378
697 GDSC1 1.6699 5.4872 0.1874 19.4431
P32/ISH GDSC1 2.0726 5.6584 0.4631 15.8094
Ku812 GDSC1 2.2803 8.2975 -0.6779 22.3596
EHEB GDSC1 2.3522 9.4889 -1.2136 24.8445
MHH-PREB-1 GDSC1 2.3942 20.7181 -6.7931 38.3363
GDM-1 GDSC1 2.7504 8.8355 -0.5611 19.9872
Karpas-45 GDSC1 2.9136 25.675 -8.8421 39.302
SIG-M5 GDSC1 2.9746 6.0932 0.9747 8.8088
Namalwa GDSC1 3.0546 10.596 -1.1971 22.3194
OPM-2 GDSC1 3.0691 11.8909 -1.8309 25.1033
SU-DHL-8 GDSC1 3.0924 10.1955 -0.9681 21.0474
MOLM-13 GDSC1 3.136 10.2731 -0.9727 20.9283
WIL2 NS GDSC1 3.2058 6.9103 0.7424 9.8496
JVM-2 GDSC1 3.2813 8.6149 -0.0397 15.0393
NALM-6 GDSC1 3.3033 9.894 -0.6555 18.6822
HC-1 GDSC1 3.329 15.8628 -3.6046 30.1631
KE-37 GDSC1 3.4252 7.4224 0.6492 9.8937
SCC-3 GDSC1 3.4329 5.226 1.6881 2.4164
ATN-1 GDSC1 3.461 6.9625 0.896 8.01
Raji GDSC1 3.4821 6.0426 1.3454 4.6914
MV4-11 GDSC1 3.5138 5.1747 1.7546 1.8493
ST486 GDSC1 3.5368 7.293 0.7889 8.5827
ALL-PO GDSC1 3.5864 10.6514 -0.8162 18.6863
SUP-HD1 GDSC1 3.5918 8.9352 0.0309 13.6447
QIMR-WIL GDSC1 3.6194 9.9081 -0.4257 16.3879
NOMO-1 GDSC1 3.651 5.1076 1.8512 1.0989
HEL GDSC1 3.6607 5.9676 1.4868 3.3263
Jiyoye GDSC1 3.6609 9.3207 -0.1077 14.3281
Karpas-422 GDSC1 3.6769 14.2413 -2.5248 25.8883
NB4 GDSC1 3.7053 5.0203 1.9107 0.7465
Reh GDSC1 3.7667 9.8332 -0.2819 15.0962
OCI-Ly19 GDSC1 3.7729 7.9066 0.6543 8.9176
DND-41 GDSC1 3.7926 9.0883 0.099 12.6283
BC-3 GDSC1 3.9201 5.7314 1.7252 1.4399
VL51 GDSC1 3.9627 8.4316 0.5304 9.2898
HL-60 GDSC1 3.9733 5.2643 1.9305 0.454
L-540 GDSC1 3.9815 14.4992 -2.4197 24.6562
Karpas-620 GDSC1 3.9896 5.581 1.8171 0.9026
H9 GDSC1 4.0344 8.2179 0.678 8.101
GR-ST GDSC1 4.0544 11.5063 -0.8924 17.7246
JSC-1 GDSC1 4.0586 6.2801 1.5656 2.1512
IM-9 GDSC1 4.0589 5.8226 1.753 1.1361
SUP-M2 GDSC1 4.0595 5.3449 1.9349 0.3873
OCI-AML-5 GDSC1 4.0718 5.4579 1.8984 0.5032
KOPN-8 GDSC1 4.0861 9.7873 -0.0353 12.6855
THP-1 GDSC1 4.0866 7.9356 0.8428 6.8471
CA46 GDSC1 4.0874 19.2628 -4.7012 30.8207
Hs 445 GDSC1 4.1019 9.3678 0.1768 11.2895
MN-60 GDSC1 4.1126 6.2763 1.5941 1.9114
L-363 GDSC1 4.1373 6.7055 1.4251 2.8763
KMS-12-BM GDSC1 4.1499 7.334 1.1554 4.5919
SUP-T1 GDSC1 4.1504 6.7204 1.4256 2.8521
OCI-AML-2 GDSC1 4.1596 5.374 1.9626 0.2595
L-1236 GDSC1 4.1684 7.6257 1.0346 5.3641
KY821 GDSC1 4.1707 9.5123 0.154 11.2595
RPMI-8226 GDSC1 4.177 9.7413 0.0487 11.9162
CTB-1 GDSC1 4.1804 14.7163 -2.3773 23.9563
SR GDSC1 4.1941 7.513 1.1006 4.8701
WSU-DLCL2 GDSC1 4.195 5.2768 2.009 0.1453
Mono-Mac-6 GDSC1 4.2001 8.0893 0.8417 6.6015
SK-MM-2 GDSC1 4.2438 6.8226 1.4307 2.6741
SU-DHL-1 GDSC1 4.2501 12.0079 -0.9968 17.7231
P31/FUJ GDSC1 4.2754 6.4112 1.6171 1.5794
JVM-3 GDSC1 4.2839 5.7612 1.8713 0.4648
HAL-01 GDSC1 4.3013 7.0515 1.3628 2.995
U-698-M GDSC1 4.3453 9.1979 0.4169 9.1145
OCI-M1 GDSC1 4.3524 5.7115 1.9153 0.3007
ME1 GDSC1 4.3855 5.4998 2 0.1149
LC4-1 GDSC1 4.4193 10.603 -0.2005 12.8305
AMO1 GDSC1 4.4224 5.6302 1.9688 0.1583
HH [Human lymphoma] GDSC1 4.424 13.9064 -1.7994 21.0065
A4/Fukuda GDSC1 4.426 11.4072 -0.5821 15.0278
NKM-1 GDSC1 4.4428 8.6552 0.7289 6.8316
OCI-AML-3 GDSC1 4.4525 5.9807 1.8572 0.4166
YT GDSC1 4.468 5.972 1.8662 0.3825
SKM-1 GDSC1 4.477 5.8555 1.9107 0.2625
MOLT-16 GDSC1 4.4814 5.8125 1.9272 0.2235
MOLT-4 GDSC1 4.5449 12.6398 -1.0955 17.4324
JJN-3 GDSC1 4.5521 5.9913 1.8908 0.2816
Granta-519 GDSC1 4.573 6.8357 1.5842 1.4142
KMOE-2 GDSC1 4.6198 6.3584 1.7854 0.5503
RPMI-6666 GDSC1 4.6258 20.2009 -4.7525 29.6705
ML-2 GDSC1 4.6432 6.2711 1.8259 0.4133
CCRF-CEM GDSC1 4.6497 7.6732 1.2782 2.966
TUR GDSC1 4.6661 12.3038 -0.8491 15.8539
L-428 GDSC1 4.6856 9.4692 0.5025 7.79
Loucy GDSC1 4.7156 6.3502 1.8251 0.382
ARH-77 GDSC1 4.7541 15.1388 -2.1636 21.6357
BC-1 GDSC1 4.7581 11.1041 -0.2145 12.0752
Kasumi-1 GDSC1 4.7642 12.1037 -0.6862 14.7356
RPMI-8402 GDSC1 4.8291 20.2638 -4.6295 28.9289
WSU-NHL GDSC1 4.8402 6.9413 1.6583 0.8582
CESS GDSC1 4.8485 12.9543 -1.0372 16.3611
DB GDSC1 4.8887 6.8053 1.728 0.582
U266B1 GDSC1 4.9651 9.8292 0.5049 7.1955
RPMI-8866 GDSC1 4.9838 6.6562 1.8166 0.2967
RS4;11 GDSC1 5.0529 13.7112 -1.2615 16.9578
EJM GDSC1 5.1185 6.9249 1.7721 0.3509
EB2 GDSC1 5.1336 17.4941 -3.0415 23.8459
LP-1 GDSC1 5.2186 6.8258 1.8419 0.1808
ROS-50 GDSC1 5.2747 11.1143 0.1041 9.0195
KG-1 GDSC1 5.3507 25.4435 -6.7968 32.0072
HDLM-2 GDSC1 5.5268 14.694 -1.4125 16.5432
KM-H2 GDSC1 5.5293 18.9998 -3.4922 24.3431
BALL-1 GDSC1 5.5639 23.5768 -5.7139 29.6682
Ramos.2G6.4C10 GDSC1 5.6831 19.4309 -3.5925 24.3
HT GDSC1 5.7198 18.56 -3.1425 22.8279
PL-21 GDSC1 5.7602 7.7755 1.7092 0.2768
BE-13 GDSC1 5.8059 22.984 -5.2431 28.2119
Karpas-299 GDSC1 5.9287 15.2848 -1.4283 15.7143
DEL GDSC1 5.9405 15.4939 -1.5196 16.1026
DG-75 GDSC1 6.1592 19.6435 -3.3599 22.5659
A3/Kawakami GDSC1 6.384 15.3443 -1.1669 13.5359
MOLP-8 GDSC1 6.7817 20.4317 -3.3125 21.1363
P30/OHK GDSC1 7.0862 19.214 -2.5321 17.8573
RL GDSC1 8.3956 19.8739 -2.0283 13.568
⏷ Show the Full List of 142 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 -0.4373 4.7776 -1.5771 39.7523
HCE-4 GDSC1 3.9843 10.8938 -0.6436 16.5747
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.8277 6.4607 1.3617 3.8425
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GI-ME-N GDSC1 1.174 13.9807 -4.4684 38.5645
KP-N-YS GDSC1 1.8443 8.1267 -0.966 25.6009
SiMa GDSC1 2.3916 9.8711 -1.3718 25.436
IMR-5 GDSC1 2.5863 6.2011 0.622 12.728
MHH-NB-11 GDSC1 2.6747 9.8507 -1.1291 23.2769
SJNB-6 GDSC1 2.7265 8.175 -0.2507 18.2145
SK-N-DZ GDSC1 3.0551 8.0399 0.0736 15.0173
SJNB-17 GDSC1 3.123 7.4612 0.4111 12.4871
SJNB-13 GDSC1 3.2572 6.4372 1.009 7.7325
NB69 GDSC1 3.3771 6.6077 1.0093 7.4049
KP-N-YN GDSC1 3.3958 11.0669 -1.1661 21.0746
Kelly GDSC1 3.477 6.1552 1.2897 5.1038
KP-N-RT-BM-1 GDSC1 3.5212 9.1975 -0.1488 14.9994
TGW GDSC1 3.5834 8.8702 0.0567 13.5017
GOTO GDSC1 3.6065 10.4305 -0.6923 17.9494
SK-N-FI GDSC1 3.8663 7.6676 0.8288 7.4605
NB(TU)1 GDSC1 4.1328 6.5428 1.4924 2.4743
LA-N-6 GDSC1 4.232 8.4241 0.7065 7.4452
SJNB-14 GDSC1 4.2811 7.2849 1.2508 3.7273
SJNB-10 GDSC1 4.6573 6.4344 1.7724 0.5711
SJNB-5 GDSC1 4.71 6.4752 1.7781 0.5224
SJNB-7 GDSC1 4.9591 11.8481 -0.4354 12.8711
SK-N-BE(2)-M17 GDSC1 5.0675 6.6757 1.8399 0.2225
CHP-126 GDSC1 5.2805 17.8784 -3.1233 23.7656
NH-12 GDSC1 5.3808 7.1345 1.7939 0.2231
NB1 GDSC1 5.6212 12.436 -0.2925 10.5932
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NOS-1 [Human HNSCC] GDSC1 -0.0044 8.4805 -2.8424 40.3557
ES6 GDSC1 0.5262 9.2131 -2.6956 37.5834
H-EMC-SS GDSC1 1.1058 6.6117 -0.8862 28.4412
SK-ES-1 GDSC1 3.6808 5.6574 1.635 2.3212
EW-3 GDSC1 3.8175 7.9484 0.6641 8.7349
SK-PN-DW GDSC1 3.8549 6.1784 1.5022 2.8672
ES1 GDSC1 4.0045 8.5795 0.4877 9.4747
EW-16 GDSC1 4.0234 15.4238 -2.8455 26.0125
EW-24 GDSC1 4.056 5.552 1.8567 0.6737
EW-1 GDSC1 4.287 8.7977 0.5671 8.2557
EW-13 GDSC1 4.3008 7.6693 1.0918 4.7202
SJSA-1 GDSC1 4.6506 7.9972 1.1403 3.7903
EW-12 GDSC1 4.8054 6.8891 1.6636 0.8634
EW-18 GDSC1 4.9847 7.1312 1.6464 0.8013
ES8 GDSC1 4.9914 16.7105 -2.7609 23.2459
TC-71 GDSC1 5.0561 6.6152 1.8564 0.1953
EW-11 GDSC1 5.268 8.0338 1.4228 1.4818
ES7 GDSC1 5.3158 13.7737 -1.1145 15.6126
ES4 GDSC1 5.3402 7.4187 1.6805 0.4939
ES5 GDSC1 5.5934 8.7816 1.2745 1.8427
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Evsa-T GDSC1 3.3265 6.7908 0.8862 8.4484
BT-474 GDSC1 3.5202 5.87 1.4485 3.8769
OCUB-M GDSC1 4.0591 12.1536 -1.206 19.3016
DU4475 GDSC1 4.0932 9.7525 -0.0136 12.5303
HCC2157 GDSC1 4.3158 6.4756 1.61 1.5686
HCC2218 GDSC1 4.3761 8.498 0.7607 6.763
CAL-148 GDSC1 4.3944 6.1789 1.7609 0.7933
MFM-223 GDSC1 4.4316 6.2592 1.746 0.824
HCC1187 GDSC1 4.5461 12.4407 -0.9982 16.938
COLO 824 GDSC1 4.6731 7.2513 1.4641 1.9045
HCC1599 GDSC1 4.9736 10.9913 -0.0239 10.4371
MRK-nu-1 GDSC1 5.2823 14.9773 -1.7136 18.4682
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-336MG GDSC1 -3.6515 -0.6857 -3.6826 71.8181
KS-1 [Human Krukenberg tumour] GDSC1 -3.5697 2.5934 -4.1772 64.3916
Becker GDSC1 -3.5084 1.7315 -3.8849 65.5435
GB-1 GDSC1 -1.2861 14.5714 -7.0007 48.7917
SNB-75 GDSC1 -1.2415 3.2569 -1.8483 46.2241
KINGS-1 GDSC1 0.5455 11.7565 -3.9268 39.9232
SF126 GDSC1 0.6045 14.8042 -5.3818 41.6463
SF268 GDSC1 0.9986 9.9676 -2.6327 35.4018
D-263MG GDSC1 1.0343 8.3638 -1.8097 32.6944
CAS-1 GDSC1 1.5128 23.6183 -8.9857 42.3182
NMC-G1 GDSC1 1.6794 8.2057 -1.1501 27.1774
GI-1 GDSC1 2.133 11.6184 -2.4622 30.5723
D-247MG GDSC1 2.9671 10.7684 -1.3523 23.347
Onda 10 GDSC1 3.2942 21.7343 -6.5627 35.9439
KALS-1 GDSC1 3.4507 11.8884 -1.5313 22.6202
ONS-76 GDSC1 3.6866 14.1052 -2.4498 25.5956
KNS-81-FD GDSC1 3.9477 5.8744 1.6797 1.6533
U-87MG ATCC GDSC1 4.528 5.7691 1.9586 0.1494
8-MG-BA GDSC1 4.6785 12.3628 -0.869 15.9269
D-502MG GDSC1 4.697 12.2197 -0.7875 15.4492
Onda 11 GDSC1 4.7169 19.1954 -4.1861 28.1181
AM-38 GDSC1 4.8676 6.5922 1.7963 0.392
D283 Med GDSC1 5.3911 15.9581 -2.1117 19.8709
KNS-42 GDSC1 5.6263 24.3477 -6.0475 30.1795
SF539 GDSC1 6.4005 18.7031 -2.742 20.0005
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 -0.047 7.6698 -2.497 39.8494
TGBC1TKB GDSC1 2.0488 6.2667 0.1392 18.1974
ETK-1 GDSC1 2.132 12.1326 -2.7201 31.3815
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 0.0449 6.0136 -1.6323 37.0218
KLE GDSC1 0.1555 15.3221 -6.0412 43.6925
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-704 GDSC1 -5.4204 -3.1601 -5.4215 89.6212
LB996-RCC GDSC1 -3.8731 -1.715 -3.8766 76.0142
RXF 393L GDSC1 -3.7404 -1.4282 -3.7468 74.2507
LB1047-RCC GDSC1 -3.2485 1.8198 -3.6227 63.7528
OS-RC-2 GDSC1 -3.0131 -0.9083 -3.0201 66.4149
A-498 GDSC1 -2.6201 6.3089 -4.4989 55.5423
RCC10RGB GDSC1 -1.5345 6.9686 -3.6598 49.3505
TK-10 GDSC1 -0.2182 5.1194 -1.4974 38.1238
BB65-RCC GDSC1 1.7633 9.2971 -1.62 28.8967
HA7-RCC GDSC1 3.0896 10.0982 -0.9219 20.816
LB2241-RCC GDSC1 5.2781 7.7698 1.5278 1.0377
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS123 GDSC1 1.4778 6.8158 -0.6422 25.4551
NCI-H747 GDSC1 2.0603 7.4916 -0.4621 21.9822
LS1034 GDSC1 3.0206 5.1989 1.4432 5.1181
C2BBe1 GDSC1 3.4722 7.2454 0.7675 8.9113
LS411N GDSC1 3.6536 8.5103 0.2819 11.8066
MDST8 GDSC1 3.9401 5.6253 1.7774 1.1443
SNU-C2B GDSC1 4.0746 11.8324 -1.0373 18.417
CW-2 GDSC1 4.3336 6.582 1.5753 1.7289
LS513 GDSC1 4.6541 6.4223 1.7755 0.5626
KM12 GDSC1 4.9193 6.2465 1.9332 0.1076
SNU-C1 GDSC1 5.0478 6.9042 1.7532 0.4278
CL-11 GDSC1 5.1897 7.2943 1.6677 0.6057
COLO 320HSR GDSC1 5.2721 12.224 -0.411 12.0114
NCI-H716 GDSC1 5.6174 13.8976 -0.9757 14.2321
RKO GDSC1 6.8959 26.1503 -6.0025 27.7059
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.5242 6.7515 1.5955 1.4106
Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LC-2/ad GDSC1 -5.1657 0.3118 -5.3984 76.7576
NCI-H1648 GDSC1 -1.0559 4.3679 -2.0601 45.0905
NCI-H1975 GDSC1 -0.437 4.8027 -1.5874 39.7811
HOP-62 GDSC1 -0.3857 4.2848 -1.3181 38.5849
LXF 289 GDSC1 0.3277 8.0481 -2.3173 37.554
NCI-H1355 GDSC1 1.7731 12.1439 -3.0317 33.5148
NCI-H1581 GDSC1 2.5742 9.0561 -0.8139 22.015
NCI-H446 GDSC1 2.7557 14.8848 -3.5784 31.7482
NCI-H82 GDSC1 3.0542 4.8464 1.6336 3.6104
NCI-H1836 GDSC1 3.2702 5.7348 1.3543 5.1343
CPC-N GDSC1 3.2952 9.1562 -0.2966 16.6083
NCI-H1694 GDSC1 3.3644 5.4152 1.5628 3.4097
NCI-H748 GDSC1 3.3784 8.6011 0.0393 14.227
NCI-H345 GDSC1 3.4349 4.2949 2.0726 0.3013
NCI-H211 GDSC1 3.4383 8.4095 0.1771 13.1349
NCI-H720 GDSC1 3.4513 5.0354 1.7815 1.784
LB647-SCLC GDSC1 3.4628 5.797 1.4472 4.0105
NCI-H2135 GDSC1 3.5721 7.0707 0.919 7.5525
DMS 114 GDSC1 3.603 9.1884 -0.0848 14.353
NCI-H1876 GDSC1 3.6471 5.2581 1.7875 1.4538
Calu-6 GDSC1 3.6476 7.2329 0.8919 7.5547
NCI-H2171 GDSC1 3.7965 5.277 1.8505 0.9388
NCI-H847 GDSC1 3.8412 5.7976 1.6587 1.9232
NCI-H1092 GDSC1 3.8819 5.6828 1.7267 1.4798
IA-LM GDSC1 3.9542 11.8691 -1.1431 19.2905
NCI-H526 GDSC1 4.0256 5.4972 1.8648 0.6652
NCI-H1869 GDSC1 4.0473 9.4746 0.0886 12.0023
COLO 668 GDSC1 4.0914 6.355 1.5506 2.1911
NCI-H2141 GDSC1 4.0948 5.7883 1.7825 0.9602
COR-L88 GDSC1 4.1137 9.0798 0.3221 10.3073
NCI-H2196 GDSC1 4.1246 11.4842 -0.8312 17.2037
NCI-H1838 GDSC1 4.1449 6.2985 1.6008 1.8307
IST-SL1 GDSC1 4.1589 11.1885 -0.6627 16.1939
Ms-1 GDSC1 4.1849 5.7663 1.8294 0.6824
NCI-H64 GDSC1 4.2082 6.1112 1.7062 1.206
NCI-H1155 GDSC1 4.3052 6.0811 1.7605 0.8677
IST-SL2 GDSC1 4.3063 13.9318 -1.8978 21.7365
NCI-H1304 GDSC1 4.3539 6.0863 1.7789 0.7527
SHP-77 GDSC1 4.3556 5.6701 1.931 0.2598
NCI-H209 GDSC1 4.3842 6.8366 1.4953 2.099
NCI-H1770 GDSC1 4.42 5.8243 1.9006 0.3103
SBC-1 GDSC1 4.5108 6.1604 1.8148 0.5175
NCI-H1963 GDSC1 4.5396 12.7044 -1.1306 17.6214
NCI-H322M GDSC1 4.588 11.9491 -0.7318 15.4293
NCI-H226 GDSC1 4.6142 18.8939 -4.1146 28.1795
NCI-H69 GDSC1 4.6151 10.1475 0.1437 10.2324
HCC33 GDSC1 4.6185 6.465 1.7457 0.6884
NCI-H2081 GDSC1 4.6497 6.2547 1.8342 0.3868
NCI-H187 GDSC1 4.6865 5.7083 2.0322 0.0386
NCI-H524 GDSC1 4.702 6.4943 1.7681 0.5591
NCI-H1666 GDSC1 4.7641 6.5489 1.7724 0.5108
DMS 79 GDSC1 4.8051 12.7671 -0.9768 16.1636
Lu-65 GDSC1 4.8278 6.5062 1.8118 0.3683
NCI-H510A GDSC1 4.9127 13.9777 -1.4866 18.3599
Lu-134-A GDSC1 5.0202 8.3668 1.1734 3.0358
Lu-139 GDSC1 5.0493 6.6326 1.8482 0.212
NCI-H23 GDSC1 5.1743 7.264 1.6726 0.5987
NCI-H128 GDSC1 5.3287 11.7564 -0.1582 10.4481
NCI-H1650 GDSC1 5.3432 8.0899 1.4336 1.3683
NCI-H1436 GDSC1 5.3507 6.9833 1.8345 0.1636
EKVX GDSC1 5.5172 7.908 1.5725 0.7244
Lu-165 GDSC1 5.6578 13.4291 -0.7302 12.8853
COR-L95 GDSC1 6.1687 15.2543 -1.2601 14.4198
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 0.7501 12.4249 -4.0722 39.3956
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 -3.1199 1.7008 -3.4547 63.0814
TE-8 GDSC1 -1.817 2.6807 -2.2907 51.6264
TE-10 GDSC1 1.9832 7.108 -0.3373 21.5452
TE-9 GDSC1 2.174 8.664 -0.9508 24.2197
TE-6 GDSC1 2.4587 5.9761 0.6309 13.1136
TE-1 GDSC1 2.6221 8.2039 -0.3492 19.1885
TE-11 GDSC1 3.7417 7.0114 1.057 6.1466
EC-GI-10 GDSC1 4.1539 7.2874 1.1786 4.4306
TE-5 GDSC1 4.1655 6.5484 1.5067 2.3399
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kuramochi GDSC1 0.6599 7.4563 -1.7161 34.1017
ES-2 GDSC1 4.5517 6.1608 1.8305 0.4456
OVCAR-4 GDSC1 5.4468 20.6205 -4.3458 26.8731
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 -1.7754 7.1022 -3.965 50.7533
PSN1 GDSC1 2.6574 24.3287 -8.3801 39.4054
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 -3.5993 2.5825 -4.2065 64.5714
IST-Mes1 GDSC1 -1.4041 2.2288 -1.7135 47.4945
MSTO-211H GDSC1 3.4275 10.6783 -0.9493 19.8786
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 3.7033 5.8587 1.5592 2.7672
LNCaP clone FGC GDSC1 4.8238 11.5629 -0.3888 12.9306
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.1634 8.0633 0.8312 6.7536
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB2518-MEL GDSC1 -4.3237 -0.7412 -4.377 76.3317
COLO 829 GDSC1 -1.9323 5.9399 -3.6257 51.8261
HT-144 GDSC1 0.3614 7.032 -1.7983 35.8668
CP67-MEL GDSC1 0.3875 5.8664 -1.2237 33.619
SH-4 GDSC1 0.8861 7.9878 -1.7623 33.197
MZ-MEL-2 GDSC1 1.5783 12.1524 -3.2044 34.6461
CP66-MEL GDSC1 1.6355 3.1061 1.2877 11.4608
MZ-MEL-7 GDSC1 2.1561 8.3446 -0.8064 23.5346
IST-MEL1 GDSC1 3.0036 12.4924 -2.183 26.6857
A-388 GDSC1 3.0758 9.8864 -0.8273 20.3604
A101D GDSC1 3.377 10.6941 -0.9956 20.2759
SK-MEL-1 GDSC1 3.7026 4.9009 1.9555 0.5542
DJM-1 GDSC1 4.0548 9.7002 -0.0148 12.6404
LB373-MEL-D GDSC1 4.0586 14.981 -2.5997 25.0851
MMAc-SF GDSC1 4.236 10.9144 -0.4756 14.9294
GAK GDSC1 4.2423 5.7098 1.8737 0.4814
UACC-257 GDSC1 4.4088 8.0009 1.0052 5.0794
COLO 800 GDSC1 4.8379 6.5857 1.7874 0.4297
SK-MEL-2 GDSC1 5.3937 13.8471 -1.0978 15.3484
LOX-IMVI GDSC1 5.5192 14.3389 -1.2486 15.7905
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -2.2896 4.466 -3.4137 54.6059
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFH-ino GDSC1 -3.0548 -0.8729 -3.0633 66.8072
SW684 GDSC1 -1.7166 44.006 -21.9532 50.0872
VA-ES-BJ GDSC1 -1.2755 7.1966 -3.4984 47.8063
SW872 GDSC1 -0.4587 4.2871 -1.396 39.3311
SW982 GDSC1 -0.2861 5.8852 -1.9067 39.7389
SK-LMS-1 GDSC1 3.608 5.4833 1.6714 2.214
TE 441.T GDSC1 4.2726 6.2835 1.6671 1.3288
SK-UT-1 GDSC1 4.4761 13.4084 -1.5183 19.631
EW-8 GDSC1 4.6058 6.2847 1.8067 0.49
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 GDSC1 -0.4414 25.6605 -11.7023 47.4951
GCIY GDSC1 -0.1421 5.6554 -1.6575 38.1769
HSC-39 GDSC1 0.0054 3.4694 -0.5807 32.8454
RF-48 GDSC1 3.5401 6.5467 1.1463 5.9882
SNU-5 GDSC1 3.6859 7.6537 0.7168 8.7036
SCH GDSC1 4.1604 5.3551 1.9695 0.2419
SNU-1 GDSC1 4.4699 6.486 1.6754 1.0919
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 4.6518 6.2572 1.8341 0.3863
K5 GDSC1 4.9594 14.0109 -1.4702 18.168
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 0.6942 7.0419 -1.4836 33.0752
BB49-HNC GDSC1 2.3628 8.9704 -0.9454 23.4784
SCC-15 GDSC1 4.5478 26.952 -8.1664 35.4395
LB771-HNC GDSC1 4.7416 13.4181 -1.335 18.0876
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW954 GDSC1 -3.0504 -1.6447 -3.0507 67.4459
LB831-BLC GDSC1 -3.0072 1.7219 -3.3368 62.2517
NT2-D1 GDSC1 -1.7725 1.0056 -1.8655 51.4769
SW962 GDSC1 -0.0237 6.3319 -1.8473 38.0715
KGN GDSC1 0.1329 8.103 -2.5299 39.0254
JAR GDSC1 3.6779 7.7117 0.6837 8.959
NEC8 GDSC1 3.72 11.0249 -0.9008 18.7353
NCC-IT GDSC1 3.7694 8.688 0.2766 11.5201
DSH1 GDSC1 4.3607 6.4028 1.6597 1.2715
OMC-1 [Human cervical carcinoma] GDSC1 4.7099 6.5532 1.7497 0.6156
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91.