Details of the Drug

General Information of Drug (ID: DMK9BP2)

Drug Name
Mavacamten
Synonyms SAR-439152; SAR 439152; SAR439152; MYK-461; MYK 461; MYK461
Indication
Disease Entry ICD 11 Status REF
Obstructive hypertrophic cardiomyopathy BC43.12 Approved [1]
ATC Code
C01EB24: Mavacamten
C01EB: Other cardiac preparations
C01E: OTHER CARDIAC PREPARATIONS
C01: CARDIAC THERAPY
C: CARDIOVASCULAR SYSTEM
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 273.33
Logarithm of the Partition Coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C15H19N3O2
IUPAC Name
6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione
Canonical SMILES
C[C@@H](C1=CC=CC=C1)NC2=CC(=O)N(C(=O)N2)C(C)C
InChI
InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
InChIKey
RLCLASQCAPXVLM-NSHDSACASA-N
Cross-matching ID
PubChem CID
117761397
CAS Number
1642288-47-8
UNII
QX45B99R3J
DrugBank ID
DB14921
TTD ID
D0D1ZF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Myosin (MYO) TTITSMB NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 214998.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)