Details of the Drug

General Information of Drug (ID: DMKBW5C)

Drug Name

Talimogene Laherparepvec

Synonyms

IMLYGIC

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Approved	[1]
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Therapeutic Class

Anticancer Agents

Affected Organisms

Humans and other mammals

ATC Code

L01XL02: Talimogene Laherparepvec

L01XL: Antineoplastic cell and gene therapy

L01X: OTHER ANTINEOPLASTIC AGENTS

L01: ANTINEOPLASTIC AGENTS

L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Drug Type

Vaccine

ADMET Property

Bioavailability: The bioavailability of drug is 100% [2]
Elimination: In an ongoing melanoma study, interim results from 30 patients show that talimogene laherparepvec DNA was detected at transient and low concentrations in blood in 90% of patients and in urine in 20% of patients in the study, which suggests that perhaps at least some portion of the drug is eliminated in the urine [3]
Metabolism: The drug is metabolized via the common endogenous protein and DNA catabolic pathways [4]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Granulocyte-macrophage colony-stimulating factor (CSF2)	TTNYZG2	CSF2_HUMAN	Modulator	[5]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Melanoma

ICD Disease Classification

2C30

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Granulocyte-macrophage colony-stimulating factor (CSF2)	DTT	CSF2	2.36E-01	-0.06	-0.26

Molecular Expression Atlas (MEA)

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Metoprolol .
3	EMA: Imylgic (talimogene laherparepvec) prescribing information
4	Electronic Medicines Compendium: Imlygic (talimogene laherparepvec) monograph
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.