Details of the Drug

General Information of Drug (ID: DMKJDR6)

Drug Name
VX-702
Synonyms ST51054128; I14-1965; EC-000.2363; 6-[carbamoyl-(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)pyridine-3-carboxamide
Indication
Disease Entry ICD 11 Status REF
Coronary artery disease BA80 Phase 2a [1]
Rheumatoid arthritis FA20 Phase 2a [1]
Inflammation 1A00-CA43.1 Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 404.3
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C19H12F4N4O2
IUPAC Name
6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)pyridine-3-carboxamide
Canonical SMILES
C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
InChI
InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
InChIKey
FYSRKRZDBHOFAY-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10341154
ChEBI ID
CHEBI:94489
CAS Number
745833-23-2
UNII
527E7SK68P
DrugBank ID
DB05470
TTD ID
D0D9AH
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Stress-activated protein kinase 2a (p38 alpha) TTQBR95 MK14_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Rheumatoid arthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Stress-activated protein kinase 2a (p38 alpha) DTT MAPK14 7.98E-04 1.33 2.48
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 4.0826 6.2314 0.3015 0.5117
EW-13 GDSC1 1.8593 6.3834 -1.0135 12.6797
CADO-ES1 GDSC1 2.0309 5.5865 -0.5013 8.5108
SJSA-1 GDSC1 2.2176 4.5629 0.1019 3.6976
SK-ES-1 GDSC1 2.4822 4.209 0.3978 1.3873
ES5 GDSC1 2.5309 5.3844 -0.086 4.3437
SaOS-2 GDSC1 2.5421 4.7531 0.1993 2.4588
EW-7 GDSC1 2.5534 10.2211 -2.3887 18.8629
MHH-ES-1 GDSC1 2.7791 5.0971 0.1753 2.2393
CHSA0011 GDSC1 2.7805 5.0998 0.1749 2.2398
CHSA0108 GDSC1 2.8128 9.865 -2.0277 16.2149
EW-3 GDSC1 2.8238 12.9553 -3.5341 23.2036
A-673 GDSC1 2.832 4.3069 0.5132 0.5305
EW-11 GDSC1 2.8406 8.5876 -1.3911 12.3911
MG-63 GDSC1 2.8479 4.5942 0.4112 0.9268
TC-71 GDSC1 2.9761 4.6514 0.4435 0.6882
ES8 GDSC1 3.0852 5.7022 0.0752 2.3808
ES1 GDSC1 3.1222 4.7019 0.4831 0.4577
ES4 GDSC1 3.1319 5.3173 0.2539 1.3781
EW-16 GDSC1 3.1966 5.8283 0.0777 2.2162
CAL-72 GDSC1 3.2445 8.8988 -1.2722 10.64
EW-24 GDSC1 3.3401 4.3915 0.6665 0.0448
G-292 clone A141B1 GDSC1 3.348 6.2656 -0.0291 2.6083
EW-18 GDSC1 3.406 12.0979 -2.6943 18.05
HOS GDSC1 3.4161 5.3376 0.3667 0.669
HuO-3N1 GDSC1 3.4453 5.4096 0.3518 0.7024
NY GDSC1 3.4819 9.1164 -1.2234 9.7883
EW-22 GDSC1 3.4976 5.5215 0.3314 0.7406
HuO9 GDSC1 3.528 6.1776 0.0922 1.7449
CHSA8926 GDSC1 3.5559 5.1832 0.475 0.2891
CAL-78 GDSC1 3.6213 5.1637 0.5051 0.2072
EW-1 GDSC1 3.7911 5.71 0.377 0.4379
ES7 GDSC1 3.8536 6.0823 0.2669 0.7386
ES6 GDSC1 3.8713 6.145 0.251 0.7821
NOS-1 [Human HNSCC] GDSC1 3.8854 5.9066 0.3426 0.4887
SK-PN-DW GDSC1 4.0686 5.6409 0.4991 0.122
H-EMC-SS GDSC1 4.1506 6.7125 0.1533 0.9451
U2OS GDSC1 4.2574 6.1922 0.3788 0.2689
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 157 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.5853 4.4951 0.3301 1.6254
SKM-1 GDSC1 0.4891 6.2373 -2.0557 24.1991
MOLT-13 GDSC1 0.6361 11.6211 -4.6167 33.3544
NCI-H929 GDSC1 1.1624 6.7604 -1.746 19.8083
A4/Fukuda GDSC1 1.2023 5.5018 -1.0846 15.3556
Karpas-422 GDSC1 1.4986 3.462 0.1557 5.0546
MOLM-16 GDSC1 1.5153 9.3407 -2.7491 23.8545
LAMA-84 GDSC1 1.5465 8.5127 -2.3112 21.6131
Reh GDSC1 1.5465 4.1968 -0.169 7.4064
KG-1 GDSC1 1.5836 3.3016 0.2917 3.7928
JURL-MK1 GDSC1 1.6135 6.5864 -1.2999 15.4123
Ku812 GDSC1 1.6638 14.7133 -5.3116 31.9049
DB GDSC1 1.6713 6.0897 -1.0093 13.2412
AMO1 GDSC1 1.6851 3.4224 0.3011 3.4686
HL-60 GDSC1 1.711 5.3822 -0.6305 10.3886
NB4 GDSC1 1.7277 4.2951 -0.0876 6.2644
Jurkat GDSC1 1.7435 3.2857 0.4013 2.6114
RCH-ACV GDSC1 1.7455 9.3042 -2.5484 22.1419
GR-ST GDSC1 1.8082 7.2989 -1.5038 16.0996
RS4;11 GDSC1 1.8589 14.3349 -4.9659 30.4963
OCI-Ly7 GDSC1 1.8812 5.9758 -0.7972 11.0862
WSU-DLCL2 GDSC1 1.8855 3.4009 0.4325 2.1077
SR GDSC1 1.8983 5.311 -0.4605 8.5806
RC-K8 GDSC1 1.9053 3.4697 0.4131 2.1997
RPMI-8226 GDSC1 1.9249 10.2115 -2.8595 23.0222
L-540 GDSC1 1.975 7.0463 -1.254 13.9578
KMS-11 GDSC1 1.9864 4.1949 0.1306 3.9977
NKM-1 GDSC1 2.0121 11.7458 -3.5545 25.6128
VAL GDSC1 2.0204 5.4541 -0.4447 8.1255
HAL-01 GDSC1 2.0331 9.4049 -2.3756 20.3595
GA-10 GDSC1 2.0377 5.6014 -0.5039 8.5108
ALL-PO GDSC1 2.0475 9.0792 -2.2033 19.4146
Karpas-1106P GDSC1 2.0521 8.2979 -1.8135 17.2168
WSU-NHL GDSC1 2.0825 6.1925 -0.7588 10.2254
ST486 GDSC1 2.1065 3.9865 0.2969 2.5929
MM1.S GDSC1 2.1307 8.6572 -1.932 17.6596
BALL-1 GDSC1 2.1321 5.2122 -0.2538 6.4359
TUR GDSC1 2.1378 4.7706 -0.0425 4.8917
KMS-12-BM GDSC1 2.1476 4.299 0.1804 3.3011
SU-DHL-16 GDSC1 2.1674 4.8005 -0.0379 4.7907
Karpas-231 GDSC1 2.1817 8.6297 -1.8804 17.2077
ARH-77 GDSC1 2.1941 4.7907 -0.0168 4.5801
JeKo-1 GDSC1 2.2087 6.7794 -0.9548 11.2423
MEG-01 GDSC1 2.2192 4.8942 -0.0492 4.7537
JSC-1 GDSC1 2.2194 5.6926 -0.4245 7.4521
KE-37 GDSC1 2.2525 3.5447 0.5584 0.8256
SUP-T1 GDSC1 2.2691 4.398 0.2058 2.8926
ATN-1 GDSC1 2.2795 6.3359 -0.6916 9.2065
EM-2 GDSC1 2.2967 5.7976 -0.4233 7.2477
MOLP-8 GDSC1 2.2985 6.7336 -0.87 10.4056
HEL GDSC1 2.3252 3.5928 0.5718 0.691
JVM-3 GDSC1 2.3344 8.2865 -1.5999 15.085
P12-Ichikawa GDSC1 2.3471 3.7459 0.5214 0.9057
L-363 GDSC1 2.3558 8.9162 -1.8928 16.7578
P31/FUJ GDSC1 2.3718 6.3 -0.6124 8.4044
MC116 GDSC1 2.4025 3.2826 0.7163 0.1488
CRO-AP2 GDSC1 2.4133 9.77 -2.2701 18.6584
A3/Kawakami GDSC1 2.4342 3.5366 0.638 0.3499
SU-DHL-5 GDSC1 2.4359 3.77 0.5513 0.6815
SK-MM-2 GDSC1 2.4408 4.8607 0.097 3.2912
HT GDSC1 2.4457 3.9498 0.4853 0.9776
Farage GDSC1 2.4473 8.3768 -1.5628 14.5319
Kasumi-1 GDSC1 2.4629 7.8692 -1.305 12.865
P32/ISH GDSC1 2.5033 4.3713 0.3411 1.6743
SUP-B15 GDSC1 2.5223 6.4974 -0.6072 7.9891
HH [Human lymphoma] GDSC1 2.5343 5.1744 0.0103 3.6895
OCI-AML-5 GDSC1 2.5369 3.9133 0.5394 0.646
MOLT-16 GDSC1 2.5502 4.3112 0.3885 1.3524
KMOE-2 GDSC1 2.5515 5.875 -0.2979 5.7594
EoL-1 GDSC1 2.5522 8.8293 -1.7086 15.1139
DND-41 GDSC1 2.5577 4.8178 0.1797 2.5553
NOMO-1 GDSC1 2.5691 7.3062 -0.9607 10.3025
MOLM-13 GDSC1 2.5811 6.1623 -0.4126 6.4912
OCI-M1 GDSC1 2.5897 3.7103 0.6353 0.2763
MLMA GDSC1 2.601 8.3316 -1.4325 13.292
BL-41 GDSC1 2.618 3.9993 0.5408 0.5773
NU-DUL-1 GDSC1 2.6235 4.2404 0.4505 0.961
RPMI-6666 GDSC1 2.6277 7.7341 -1.1261 11.2513
Mono-Mac-6 GDSC1 2.641 6.9374 -0.7378 8.6013
Daudi GDSC1 2.6677 4.3337 0.4335 0.9963
ME1 GDSC1 2.6705 4.8005 0.2452 1.9896
KM-H2 GDSC1 2.6765 5.2661 0.0489 3.1781
DG-75 GDSC1 2.687 5.0642 0.142 2.5791
MV4-11 GDSC1 2.7063 8.6241 -1.5008 13.4292
CTV-1 GDSC1 2.7271 14.2812 -4.2619 26.0485
L-1236 GDSC1 2.7288 5.4725 -0.0128 3.482
IM-9 GDSC1 2.7416 4.0047 0.5878 0.3393
Karpas-299 GDSC1 2.7435 4.5702 0.3742 1.2035
SUP-HD1 GDSC1 2.7563 9.4669 -1.8741 15.5083
U-698-M GDSC1 2.7704 5.573 -0.0341 3.5446
HDLM-2 GDSC1 2.7723 6.0936 -0.2653 5.0672
OPM-2 GDSC1 2.7726 4.4834 0.4213 0.951
DoHH2 GDSC1 2.7812 4.328 0.4846 0.6742
CML-T1 GDSC1 2.7949 7.2832 -0.8014 8.6594
VL51 GDSC1 2.8355 6.2956 -0.3197 5.3037
WIL2 NS GDSC1 2.8395 7.4615 -0.8566 8.9231
JVM-2 GDSC1 2.8497 9.9919 -2.0633 16.3097
Namalwa GDSC1 2.8506 4.7494 0.3517 1.1998
ML-2 GDSC1 2.8572 12.151 -3.1136 21.3976
TK [Human B-cell lymphoma] GDSC1 2.8738 4.9715 0.2735 1.5682
Sc-1 GDSC1 2.8854 4.4043 0.4986 0.5472
CCRF-CEM GDSC1 2.9009 8.995 -1.5457 13.1841
PF-382 GDSC1 2.929 7.7028 -0.9125 9.0812
Jiyoye GDSC1 2.9302 6.0709 -0.1649 4.1001
QIMR-WIL GDSC1 2.9632 9.0865 -1.5472 13.0311
JJN-3 GDSC1 2.9941 8.9819 -1.4763 12.5199
Loucy GDSC1 3.0225 4.7728 0.417 0.7566
BE-13 GDSC1 3.0335 10.053 -1.9643 15.2688
MHH-PREB-1 GDSC1 3.0456 4.5968 0.4914 0.4739
SU-DHL-6 GDSC1 3.0483 4.4484 0.5456 0.3138
SUP-M2 GDSC1 3.0698 4.1689 0.6493 0.099
Raji GDSC1 3.0835 4.619 0.4981 0.4322
CA46 GDSC1 3.1015 5.1911 0.29 1.2375
LP-1 GDSC1 3.1288 4.7375 0.4728 0.4866
RL GDSC1 3.1288 4.5573 0.5372 0.3019
SUP-B8 GDSC1 3.1288 4.8707 0.4239 0.6538
U266B1 GDSC1 3.1348 6.2427 -0.1287 3.5175
THP-1 GDSC1 3.1456 4.9927 0.3852 0.7884
K-562 GDSC1 3.1609 5.0603 0.366 0.8527
ALL-SIL GDSC1 3.1865 4.9714 0.4098 0.666
CMK GDSC1 3.1914 4.5179 0.5736 0.1975
KOPN-8 GDSC1 3.1964 4.8414 0.4614 0.485
697 GDSC1 3.205 9.2977 -1.4864 12.0512
CESS GDSC1 3.2098 4.9361 0.4322 0.5727
MOLT-4 GDSC1 3.2264 9.0769 -1.3679 11.2758
BV-173 GDSC1 3.2275 13.1401 -3.3286 21.3078
Karpas-620 GDSC1 3.2314 4.5899 0.5631 0.2065
YT GDSC1 3.2458 9.8996 -1.746 13.4836
OCI-Ly19 GDSC1 3.2493 5.2252 0.3406 0.8856
ROS-50 GDSC1 3.2766 8.0408 -0.8525 7.8967
MHH-CALL-2 GDSC1 3.2879 4.7233 0.5374 0.2424
H9 GDSC1 3.3831 4.9361 0.4981 0.2982
Ramos.2G6.4C10 GDSC1 3.3979 12.9139 -3.0961 19.8889
OCI-AML-2 GDSC1 3.4166 4.4501 0.6726 0.0344
EJM GDSC1 3.4477 5.5035 0.3179 0.8248
P30/OHK GDSC1 3.464 4.984 0.5108 0.242
L-428 GDSC1 3.467 5.095 0.4733 0.3259
HC-1 GDSC1 3.5215 5.12 0.4844 0.2799
GDM-1 GDSC1 3.5451 5.2953 0.4317 0.3997
MY-M12 GDSC1 3.5883 5.2566 0.4612 0.3089
SU-DHL-4 GDSC1 3.599 4.9548 0.5677 0.1135
BC-1 GDSC1 3.6216 5.2245 0.4844 0.2474
RPMI-8402 GDSC1 3.6277 5.3267 0.4512 0.3178
RPMI-8866 GDSC1 3.6305 11.6165 -2.3083 15.5871
Karpas-45 GDSC1 3.6439 13.0306 -2.9799 18.7602
PL-21 GDSC1 3.6719 7.8526 -0.5392 5.1355
EB2 GDSC1 3.6926 5.3751 0.4579 0.2802
CTB-1 GDSC1 3.694 12.5972 -2.736 17.5251
Granta-519 GDSC1 3.7013 5.261 0.5001 0.1953
KCL-22 GDSC1 3.8308 5.523 0.4565 0.2409
OCI-AML-3 GDSC1 3.866 12.5706 -2.6063 16.4936
DEL GDSC1 4.1448 12.2382 -2.2642 14.1517
MN-60 GDSC1 4.2469 12.4119 -2.2801 14.0034
LC4-1 GDSC1 4.2924 6.2809 0.3609 0.2937
NALM-6 GDSC1 4.3972 12.1066 -2.042 12.4471
EHEB GDSC1 4.6523 15.5581 -3.5063 18.6213
KY821 GDSC1 5.0243 23.7852 -7.2376 28.4131
⏷ Show the Full List of 157 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC1 0.8942 8.6418 -2.9094 26.7533
KYAE-1 GDSC1 2.1882 6.0285 -0.6062 8.8424
FLO-1 GDSC1 2.6071 5.8321 -0.2444 5.2685
HCE-4 GDSC1 2.906 15.21 -4.5858 26.5947
ESO-26 GDSC1 2.9222 7.8346 -0.9789 9.5358
SK-GT-4 GDSC1 3.2882 5.8614 0.1081 1.938
KYSE-50 GDSC1 3.3765 4.8779 0.5159 0.2597
KYSE-220 GDSC1 3.6776 5.4797 0.416 0.3844
OACM5.1 C GDSC1 3.8039 5.8082 0.3469 0.5153
OACP4 C GDSC1 4.1057 6.5107 0.2097 0.7784
TE-12 GDSC1 4.9117 13.7327 -2.4767 13.5515
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 2.3499 7.6622 -1.2842 13.0485
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-AS GDSC1 1.3429 2.5886 0.4701 3.0888
MHH-NB-11 GDSC1 1.8872 14.4308 -4.9911 30.4825
SJNB-5 GDSC1 2.1067 3.9838 0.2982 2.5839
CHP-212 GDSC1 2.1114 4.2145 0.1973 3.2587
SK-N-MC-IXC GDSC1 2.2141 3.2328 0.662 0.4078
SJNB-6 GDSC1 2.3364 4.157 0.347 1.8821
CHP-126 GDSC1 2.4143 7.2833 -1.0554 11.3548
IMR-5 GDSC1 2.452 4.1793 0.3954 1.4388
SJNB-7 GDSC1 2.6518 4.5053 0.3578 1.392
SK-N-DZ GDSC1 2.7339 3.9594 0.6011 0.3046
SJNB-14 GDSC1 2.7464 4.9617 0.2157 2.0521
KP-N-YS GDSC1 2.7697 5.0188 0.2035 2.0892
SK-N-FI GDSC1 2.7997 4.5594 0.4036 1.006
NB69 GDSC1 2.808 6.5599 -0.4567 6.2882
TGW GDSC1 2.8458 4.6994 0.3692 1.1206
NB(TU)1 GDSC1 2.908 12.5781 -3.2861 21.9835
NB1 GDSC1 2.9249 4.5145 0.4737 0.6111
SJNB-17 GDSC1 2.9393 5.0596 0.2686 1.5166
GOTO GDSC1 3.1233 5.0606 0.3501 0.9493
SK-N-BE(2)-M17 GDSC1 3.1656 4.6318 0.5246 0.3188
Kelly GDSC1 3.2037 4.6293 0.5395 0.2671
SJNB-13 GDSC1 3.2926 4.917 0.4711 0.4068
SK-N-SH GDSC1 3.3457 5.2573 0.3681 0.7098
NH-12 GDSC1 3.4026 5.6331 0.2498 1.137
LA-N-6 GDSC1 3.4106 4.8493 0.5379 0.2036
KP-N-YN GDSC1 3.4133 5.2117 0.4115 0.5227
SJNB-12 GDSC1 3.7389 5.8339 0.3125 0.6556
SJNB-10 GDSC1 3.7475 5.3411 0.4891 0.2029
GI-ME-N GDSC1 3.9206 6.3093 0.21 0.895
SiMa GDSC1 4.1958 5.9071 0.4538 0.1595
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 3.0417 4.4653 0.5372 0.3394
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAMA-1 GDSC1 1.3618 2.8785 0.3425 4.0124
DU4475 GDSC1 1.8433 8.2543 -1.9505 18.6697
Hs 578T GDSC1 2.176 3.8839 0.38 1.9341
MDA-MB-157 GDSC1 2.2813 16.1535 -5.5372 30.7682
HCC1419 GDSC1 2.3467 4.0729 0.3877 1.6264
HCC1500 GDSC1 2.4828 7.4413 -1.0843 11.3621
EFM-192A GDSC1 2.4929 4.8219 0.143 2.8968
HCC2218 GDSC1 2.5333 20.054 -7.2813 33.6207
MRK-nu-1 GDSC1 2.5878 6.6875 -0.6544 8.1566
BT-20 GDSC1 2.6167 5.1248 0.0781 3.0959
CAL-85-1 GDSC1 2.6901 5.66 -0.1178 4.2419
CAL-120 GDSC1 2.7118 4.0703 0.5523 0.4703
BT-474 GDSC1 2.7119 4.332 0.4536 0.8625
Evsa-T GDSC1 2.7852 4.231 0.5224 0.5283
JIMT-1 GDSC1 2.8102 4.3601 0.4845 0.6526
HCC2157 GDSC1 2.8471 4.6099 0.4047 0.9561
HCC1428 GDSC1 2.9277 4.6137 0.4376 0.748
EFM-19 GDSC1 3.0171 5.2138 0.2427 1.5596
MDA-MB-330 GDSC1 3.0739 5.7448 0.0518 2.5314
MDA-MB-361 GDSC1 3.0929 5.2059 0.2804 1.2916
OCUB-M GDSC1 3.1377 4.8499 0.4352 0.6076
ZR-75-30 GDSC1 3.1425 4.7933 0.4579 0.5272
MFM-223 GDSC1 3.214 4.7035 0.5173 0.3173
MDA-MB-175-VII GDSC1 3.2347 4.6273 0.5514 0.2298
HCC1954 GDSC1 3.2356 4.9457 0.4388 0.5353
HCC1187 GDSC1 3.3014 11.4841 -2.4701 17.2313
CAL-51 GDSC1 3.3593 5.5589 0.2598 1.1321
MDA-MB-468 GDSC1 3.3675 5.1102 0.4304 0.4888
HDQ-P1 GDSC1 3.3677 5.0211 0.4624 0.396
HCC1806 GDSC1 3.3833 5.4667 0.3051 0.9228
HCC202 GDSC1 3.4213 5.7058 0.2299 1.2073
MDA-MB-453 GDSC1 3.4792 5.205 0.439 0.4094
HCC1937 GDSC1 3.4816 5.3361 0.393 0.5433
HCC70 GDSC1 3.4872 5.2935 0.4105 0.487
BT-483 GDSC1 3.5016 5.0805 0.4909 0.2723
MDA-MB-436 GDSC1 3.5171 5.5802 0.3175 0.7777
BT-549 GDSC1 3.5174 5.5556 0.3268 0.744
T-47D GDSC1 3.5225 5.6219 0.3042 0.8231
COLO 824 GDSC1 3.5594 5.6875 0.2948 0.8322
MDA-MB-231 GDSC1 3.5612 6.0746 0.1478 1.4463
MCF-7 GDSC1 3.7796 5.6023 0.4106 0.3572
MDA-MB-415 GDSC1 3.8487 5.6474 0.4201 0.3105
UACC-893 GDSC1 3.9112 5.8672 0.3662 0.415
HCC38 GDSC1 4.0298 5.7414 0.4521 0.1972
AU565 GDSC1 4.2901 6.5153 0.2786 0.482
HCC1395 GDSC1 4.4138 6.1964 0.4316 0.1498
HCC1569 GDSC1 4.5091 6.6369 0.3159 0.3187
HCC1143 GDSC1 4.5765 6.8257 0.275 0.3828
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 GDSC1 1.6041 4.0558 -0.0584 6.3913
MOG-G-UVW GDSC1 1.6717 3.7019 0.1595 4.5536
NMC-G1 GDSC1 2.0082 3.6997 0.3689 2.2995
GI-1 GDSC1 2.083 4.4062 0.0925 4.0527
D283 Med GDSC1 2.1988 6.804 -0.9738 11.4009
KNS-42 GDSC1 2.3205 4.441 0.2154 2.7348
CAS-1 GDSC1 2.3373 3.6038 0.5728 0.6753
Hs 683 GDSC1 2.3601 3.8003 0.5057 0.9692
A-172 GDSC1 2.3817 4.8632 0.0622 3.6376
KNS-81-FD GDSC1 2.4233 6.8554 -0.8433 9.8843
U-87MG ATCC GDSC1 2.5305 3.9757 0.5128 0.7655
D-336MG GDSC1 2.6017 5.8976 -0.2777 5.5095
U-251MG GDSC1 2.6171 4.2336 0.4503 0.968
D-566MG GDSC1 2.6361 7.2916 -0.909 9.7803
LN-405 GDSC1 2.7035 4.3493 0.4432 0.9169
GaMG GDSC1 2.7657 14.2796 -4.2318 25.8473
DK-MG GDSC1 2.7669 4.5434 0.3954 1.0768
D-247MG GDSC1 2.7874 5.0922 0.1816 2.1909
LN-18 GDSC1 2.8024 4.0439 0.5968 0.285
DBTRG-05MG GDSC1 2.8109 5.0706 0.2023 2.0383
D-263MG GDSC1 2.8366 4.1748 0.5631 0.3643
YH-13 GDSC1 2.8473 4.6318 0.3963 0.9938
T98G GDSC1 2.933 4.6885 0.4114 0.8513
D-542MG GDSC1 2.9367 4.3442 0.5406 0.3803
42-MG-BA GDSC1 2.975 4.908 0.3448 1.1071
H4 GDSC1 2.988 6.9811 -0.5411 6.4693
Becker GDSC1 2.9998 5.7286 0.0209 2.8235
U-118MG GDSC1 3.0113 4.5543 0.4935 0.4869
SF539 GDSC1 3.0116 4.5119 0.509 0.4371
LN-229 GDSC1 3.0415 4.6642 0.4652 0.5641
SF295 GDSC1 3.0536 4.7752 0.4289 0.6875
YKG-1 GDSC1 3.0569 4.4273 0.5563 0.283
KALS-1 GDSC1 3.1013 5.8455 0.0233 2.6574
SW1783 GDSC1 3.1407 5.3208 0.2565 1.3564
SF126 GDSC1 3.2608 4.4794 0.6109 0.1166
D-502MG GDSC1 3.2971 5.442 0.278 1.108
Onda 10 GDSC1 3.302 5.2135 0.3667 0.7451
SK-MG-1 GDSC1 3.3223 5.5912 0.2312 1.2941
SW1088 GDSC1 3.4224 5.5454 0.2917 0.9461
ONS-76 GDSC1 3.4338 5.989 0.1243 1.689
8-MG-BA GDSC1 3.4361 5.2289 0.4141 0.5024
KINGS-1 GDSC1 3.4519 5.3459 0.3778 0.6091
LNZTA3WT4 GDSC1 3.4633 5.1018 0.4695 0.3366
Daoy GDSC1 3.5187 5.1761 0.4639 0.3286
M059J GDSC1 3.5202 5.4396 0.3704 0.5934
D-392MG GDSC1 3.6123 6.6402 -0.055 2.4031
SF268 GDSC1 3.6426 5.4972 0.3967 0.4511
GB-1 GDSC1 3.8153 5.2818 0.5325 0.122
KS-1 [Human Krukenberg tumour] GDSC1 3.9594 6.112 0.2973 0.5829
Onda 11 GDSC1 3.9601 5.8054 0.4056 0.3048
PFSK-1 GDSC1 3.9607 5.7881 0.4118 0.2916
D-423MG GDSC1 4.0637 6.3413 0.2549 0.6572
MOG-G-CCM GDSC1 4.1487 6.1248 0.3631 0.3341
SNB-75 GDSC1 4.1602 5.8003 0.4772 0.1344
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.9893 4.3547 0.058 4.5143
TGBC1TKB GDSC1 3.2321 4.6783 0.5328 0.2724
TGBC24TKB GDSC1 3.3498 5.3822 0.3231 0.8771
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1 1.1155 5.6192 -1.2141 16.5637
EN GDSC1 3.0577 4.1832 0.6404 0.1143
RL95-2 GDSC1 3.3266 5.1669 0.3938 0.6313
ESS-1 GDSC1 3.3293 4.8606 0.5047 0.3027
MFE-296 GDSC1 3.7092 5.7582 0.3284 0.6211
KLE GDSC1 4.1828 6.3142 0.3095 0.4474
MFE-280 GDSC1 4.2667 6.6412 0.2249 0.6415
AN3-CA GDSC1 4.3246 6.1181 0.4273 0.1722
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-1M GDSC1 1.5574 3.3811 0.2359 4.2812
KTCTL-140 GDSC1 1.5755 4.1765 -0.1379 7.0822
KTCTL-26A GDSC1 1.9997 3.9198 0.2651 3.0203
BFTC-909 GDSC1 2.0938 3.7629 0.3884 2.0191
CAL-54 GDSC1 2.2192 5.7514 -0.4526 7.655
VMRC-RCW GDSC1 2.2864 9.6231 -2.2921 19.1513
Caki-1 GDSC1 2.3527 11.9581 -3.3966 23.9924
BB65-RCC GDSC1 2.4 5.4908 -0.2136 5.5088
KTCTL-13 GDSC1 2.444 4.4121 0.294 2.0362
KMRC-1 GDSC1 2.5452 4.1095 0.467 0.9616
LB2241-RCC GDSC1 2.6477 5.0357 0.1335 2.6946
A-498 GDSC1 2.6519 3.9866 0.5592 0.4847
KMRC-20 GDSC1 2.6906 4.7588 0.2725 1.8059
UO-31 GDSC1 2.8766 4.7703 0.3551 1.1564
NCC021 GDSC1 2.8928 5.4772 0.0726 2.678
ACHN GDSC1 3.011 10.1295 -2.0169 15.6198
SN12C GDSC1 3.0201 4.6254 0.4709 0.5577
OS-RC-2 GDSC1 3.1962 5.4913 0.214 1.5041
RCC10RGB GDSC1 3.2812 12.6293 -3.0406 19.9484
SW13 GDSC1 3.2956 5.0054 0.4405 0.4961
A-704 GDSC1 3.3584 4.897 0.5026 0.2966
769-P GDSC1 3.5106 5.453 0.3618 0.6274
786-O GDSC1 3.5252 5.3126 0.4181 0.4461
TK-10 GDSC1 3.6261 5.9438 0.226 1.05
RXF 393L GDSC1 3.6611 5.9494 0.2384 0.9735
HA7-RCC GDSC1 3.7323 5.4753 0.4376 0.3116
LB1047-RCC GDSC1 4.0231 6.0259 0.3518 0.4059
KTCTL-195 GDSC1 4.0869 5.8234 0.4443 0.1968
SW156 GDSC1 4.0965 5.9562 0.4025 0.2692
NCC010 GDSC1 4.5624 6.4319 0.4038 0.1603
VMRC-RCZ GDSC1 4.9132 13.2121 -2.2349 12.3648
KTCTL-21 GDSC1 6.2262 31.1234 -9.9593 30.8679
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 GDSC1 1.3664 11.6359 -4.0158 29.2303
LS123 GDSC1 1.5336 3.7845 0.0235 5.9675
CaR-1 GDSC1 1.6717 4.0644 -0.0149 5.8694
HT-29 GDSC1 1.996 4.1163 0.1729 3.6745
SW1116 GDSC1 2.3235 11.9356 -3.4078 24.1219
HT115 GDSC1 2.3909 3.6672 0.5714 0.634
COLO 320HSR GDSC1 2.4105 5.4066 -0.1682 5.1663
CL-11 GDSC1 2.4787 5.4834 -0.1621 4.9754
RCM-1 [Human ESC] GDSC1 2.527 4.4502 0.32 1.7617
SNU-C1 GDSC1 2.5304 8.1021 -1.3706 13.097
NCI-H508 GDSC1 2.5455 10.1032 -2.3367 18.6192
C2BBe1 GDSC1 2.6292 5.454 -0.0605 3.9783
LS1034 GDSC1 2.6327 4.6427 0.2922 1.7739
LS411N GDSC1 2.7057 4.1053 0.5369 0.5292
SW48 GDSC1 2.7526 4.6352 0.3524 1.3024
HCT 116 GDSC1 2.7758 4.3793 0.4628 0.7673
SW837 GDSC1 2.7832 4.9538 0.2372 1.8794
LS513 GDSC1 2.7839 4.3015 0.4956 0.6289
COLO 678 GDSC1 2.8422 5.1469 0.1861 2.0875
SNU-61 GDSC1 2.9316 4.4367 0.5051 0.4959
SW948 GDSC1 2.9749 4.2362 0.593 0.2264
KM12 GDSC1 3.002 4.5154 0.504 0.4581
LS180 GDSC1 3.0483 4.6311 0.48 0.5097
SK-CO-1 GDSC1 3.1107 4.7782 0.4508 0.5704
COLO205 GDSC1 3.1263 8.4751 -1.1489 10.1455
SW1463 GDSC1 3.1664 4.5107 0.5671 0.2185
SNU-81 GDSC1 3.1885 4.6574 0.5241 0.3106
HCT 15 GDSC1 3.2308 4.74 0.5107 0.3274
HT-55 GDSC1 3.2374 4.7225 0.5193 0.3029
MDST8 GDSC1 3.286 4.7153 0.5395 0.2386
CW-2 GDSC1 3.3451 5.1598 0.4037 0.5864
SW620 GDSC1 3.4051 5.0671 0.4601 0.3853
NCI-H747 GDSC1 3.4683 5.8678 0.1875 1.3537
SW1417 GDSC1 3.491 4.977 0.5228 0.2099
SNU-407 GDSC1 3.5107 5.2099 0.4491 0.3689
GP5d GDSC1 3.5108 5.037 0.5093 0.2306
HCC2998 GDSC1 3.5273 5.2179 0.4524 0.3537
SNU-C5 GDSC1 3.6454 5.5548 0.3772 0.5054
CCK-81 GDSC1 3.6469 5.5252 0.3883 0.4725
LoVo GDSC1 3.8195 5.7241 0.3826 0.411
SW626 GDSC1 3.9203 5.9938 0.3248 0.5224
T84 GDSC1 3.9254 6.0218 0.3167 0.543
DiFi GDSC1 4.086 6.3007 0.278 0.5762
RKO GDSC1 4.0873 6.1011 0.3491 0.3878
SNU-C2B GDSC1 4.375 6.6916 0.2479 0.5257
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 2.8794 5.3165 0.1337 2.3361
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 1.4822 3.4013 0.1736 4.9639
HuH-1 GDSC1 1.7601 7.9951 -1.886 18.5698
JHH-6 GDSC1 2.1291 3.476 0.5283 1.1275
SK-HEP-1 GDSC1 2.4115 3.9397 0.4737 1.0733
SNU-423 GDSC1 2.5234 4.4644 0.3123 1.8111
Hep-G2/C3A GDSC1 2.8322 4.2441 0.5363 0.451
Hep 3B2.1-7 GDSC1 3.2736 4.8878 0.4743 0.4068
JHH-7 GDSC1 3.3028 5.0799 0.4163 0.57
Huh-7 GDSC1 3.3179 4.9231 0.4785 0.3747
SNU-398 GDSC1 3.4395 5.1979 0.4265 0.4636
SNU-387 GDSC1 3.4984 5.11 0.4796 0.2991
SNU-449 GDSC1 3.547 5.3833 0.4011 0.4845
JHH-2 GDSC1 3.5642 5.3365 0.4243 0.4112
HLE GDSC1 3.6896 5.6015 0.3773 0.4834
JHH-4 GDSC1 3.8204 5.5712 0.4362 0.285
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 176 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2803 GDSC1 -6.1551 0.4425 -6.6637 71.646
NCI-H23 GDSC1 0.5179 2.7611 -0.3087 12.2033
NCI-H2795 GDSC1 1.147 4.094 -0.4262 10.6884
CPC-N GDSC1 1.3495 3.073 0.2384 4.8533
NCI-H82 GDSC1 1.5091 4.8256 -0.5069 10.0961
NCI-H1299 GDSC1 1.5902 7.0569 -1.5517 17.1168
UMC-11 GDSC1 1.7554 4.4256 -0.1314 6.5192
IA-LM GDSC1 1.8945 3.7904 0.2611 3.2735
SBC-5 GDSC1 1.9677 2.9609 0.6608 0.6282
NCI-H345 GDSC1 2.0161 3.347 0.5261 1.2968
NCI-H2444 GDSC1 2.0572 3.1673 0.6196 0.7346
NCI-H720 GDSC1 2.0577 22.5642 -8.9138 36.9592
NCI-H290 GDSC1 2.0582 4.7036 -0.0616 5.2182
Ms-1 GDSC1 2.0587 6.2915 -0.8238 10.7549
NCI-H1092 GDSC1 2.0838 5.1808 -0.2708 6.6824
NCI-H1770 GDSC1 2.1526 4.0492 0.295 2.5195
BEN GDSC1 2.1602 2.9668 0.7378 0.1906
NCI-H2030 GDSC1 2.1975 15.1638 -5.1103 29.9369
LB647-SCLC GDSC1 2.216 6.7863 -0.9531 11.2098
COR-L88 GDSC1 2.2291 16.4681 -5.7351 31.3586
NCI-H1105 GDSC1 2.2342 4.925 -0.0541 4.7548
NCI-H510A GDSC1 2.2366 8.3657 -1.71 16.0409
NCI-H2081 GDSC1 2.2631 5.6145 -0.3586 6.8667
NCI-H650 GDSC1 2.2953 4.157 0.3255 2.078
LCLC-97TM1 GDSC1 2.3424 4.8207 0.0585 3.7409
NCI-H2023 GDSC1 2.3628 5.9647 -0.4592 7.3395
NCI-H187 GDSC1 2.3642 3.8327 0.4947 1.0201
NCI-H1792 GDSC1 2.3983 5.2807 -0.1177 4.8405
SK-LU-1 GDSC1 2.3992 4.493 0.2356 2.4684
NCI-H526 GDSC1 2.4314 6.4907 -0.6636 8.6123
NCI-H1155 GDSC1 2.436 6.2246 -0.5344 7.6911
SW1573 GDSC1 2.4464 5.593 -0.2322 5.5353
SHP-77 GDSC1 2.4605 3.6837 0.5943 0.4874
LCLC-103H GDSC1 2.4647 4.8464 0.1167 3.1173
HCC78 GDSC1 2.4698 4.2803 0.3624 1.5993
COR-L321 GDSC1 2.4801 7.6703 -1.1968 12.1134
NCI-H2122 GDSC1 2.4819 4.1092 0.4382 1.1739
NCI-H1436 GDSC1 2.4852 6.0022 -0.3982 6.6129
A-549 GDSC1 2.5125 4.619 0.2413 2.2486
NCI-H292 GDSC1 2.517 4.5413 0.2766 2.0294
Calu-3 GDSC1 2.5361 5.1227 0.0343 3.5266
COR-L105 GDSC1 2.5413 5.3516 -0.0651 4.1814
NCI-H810 GDSC1 2.5447 4.5717 0.2779 1.9804
NCI-H64 GDSC1 2.5648 3.7891 0.5972 0.4079
NCI-H1694 GDSC1 2.6093 5.1504 0.0628 3.2073
NCI-H226 GDSC1 2.6369 4.4811 0.3606 1.3951
NCI-H146 GDSC1 2.6619 8.1984 -1.326 12.454
NCI-H2804 GDSC1 2.6761 11.07 -2.7156 20.1139
EMC-BAC-1 GDSC1 2.7349 7.3216 -0.8582 9.1893
NCI-H1781 GDSC1 2.7351 4.0463 0.5703 0.3967
Lu-165 GDSC1 2.7575 4.6701 0.3407 1.3564
NCI-H1304 GDSC1 2.7646 4.3946 0.4522 0.8218
LK-2 GDSC1 2.7668 4.8115 0.2878 1.6231
NCI-H358 GDSC1 2.7671 4.9551 0.2287 1.949
RERF-LC-MS GDSC1 2.7844 4.6809 0.3487 1.2854
NCI-H1650 GDSC1 2.7848 4.7469 0.3225 1.4182
A-427 GDSC1 2.8332 6.1853 -0.2712 4.9834
NCI-H2810 GDSC1 2.8501 5.3626 0.0993 2.5835
NCI-H1341 GDSC1 2.8532 4.4674 0.4619 0.7089
DMS 273 GDSC1 2.8621 4.3954 0.4925 0.585
NCI-H1573 GDSC1 2.8634 4.5593 0.4312 0.8264
NCI-H196 GDSC1 2.8734 10.4589 -2.2736 17.3688
NCI-H1581 GDSC1 2.8763 4.4117 0.4922 0.5764
HOP-62 GDSC1 2.9031 4.3647 0.5201 0.4628
NCI-H1993 GDSC1 2.9041 4.8209 0.3475 1.1648
NCI-H2029 GDSC1 2.9463 4.226 0.5861 0.2531
COR-L279 GDSC1 2.9514 4.6009 0.4522 0.6728
COR-L23 GDSC1 2.9577 4.4068 0.5261 0.4131
NCI-H1435 GDSC1 2.9653 5.1986 0.2245 1.7156
NCI-H2110 GDSC1 2.984 5.8405 -0.0352 3.1888
NCI-H524 GDSC1 2.985 10.831 -2.3755 17.5909
LXF 289 GDSC1 3 7.1394 -0.6064 6.8792
NCI-H2085 GDSC1 3.0027 5.8729 -0.0393 3.1836
NCI-H1876 GDSC1 3.0036 5.1484 0.2626 1.4736
NCI-H3255 GDSC1 3.0151 4.6503 0.4598 0.6005
NCI-H446 GDSC1 3.0163 5.474 0.1361 2.1321
NCI-H2595 GDSC1 3.0202 9.7371 -1.8211 14.4954
NCI-H835 GDSC1 3.0215 5.5372 0.1124 2.258
NCI-H847 GDSC1 3.0326 4.5946 0.4872 0.4952
RERF-LC-KJ GDSC1 3.0388 4.4014 0.5587 0.2842
NCI-H2227 GDSC1 3.0427 9.4838 -1.6839 13.64
IST-SL1 GDSC1 3.0697 6.158 -0.1268 3.6141
DMS 79 GDSC1 3.0706 4.6648 0.4765 0.5082
NCI-H838 GDSC1 3.0797 4.7489 0.4492 0.5955
NCI-H1355 GDSC1 3.081 6.3664 -0.2117 4.1284
NCI-H2141 GDSC1 3.0909 4.4886 0.5473 0.2918
NCI-H1568 GDSC1 3.0968 5.4713 0.1759 1.8124
NCI-H1648 GDSC1 3.1039 5.8097 0.0396 2.5586
NCI-H1793 GDSC1 3.108 5.3253 0.2399 1.472
NCI-H2135 GDSC1 3.1092 4.5277 0.5403 0.3019
Lu-134-A GDSC1 3.111 6.8923 -0.4283 5.4717
NCI-H2369 GDSC1 3.1213 4.2847 0.6282 0.1193
NCI-H441 GDSC1 3.1397 4.7964 0.4556 0.5363
IST-SL2 GDSC1 3.1417 5.4225 0.2166 1.551
NCI-H727 GDSC1 3.1711 5.4821 0.2062 1.5701
COR-L95 GDSC1 3.1734 4.5426 0.5586 0.2345
Lu-139 GDSC1 3.1865 14.6119 -4.0808 24.2406
NCI-H2722 GDSC1 3.1885 4.8747 0.4462 0.5385
NCI-H2172 GDSC1 3.1919 4.6977 0.5111 0.3428
NCI-H460 GDSC1 3.238 4.3671 0.6405 0.082
NCI-H1963 GDSC1 3.239 5.047 0.403 0.6554
NCI-H2461 GDSC1 3.2496 4.9489 0.4431 0.5133
NCI-H1563 GDSC1 3.2634 4.8637 0.479 0.3983
NCI-H3122 GDSC1 3.2667 5.0711 0.4052 0.6298
CAL-12T GDSC1 3.2675 5.8543 0.1011 1.9998
NCI-H2170 GDSC1 3.2783 5.1385 0.3849 0.6943
DMS 114 GDSC1 3.2976 4.833 0.5027 0.3202
Lu-65 GDSC1 3.2984 5.2753 0.3421 0.8418
NCI-H1734 GDSC1 3.33 5.3994 0.3083 0.9521
SK-MES-1 GDSC1 3.3517 5.0503 0.4459 0.4506
RERF-LC-Sq1 GDSC1 3.353 6.6822 -0.2026 3.6154
NCI-H1975 GDSC1 3.3752 5.2762 0.373 0.6731
LC-2/ad GDSC1 3.3758 5.3556 0.3438 0.7787
NCI-H841 GDSC1 3.3814 5.1301 0.4286 0.4871
SW1271 GDSC1 3.3917 5.3194 0.3636 0.6954
NCI-H2066 GDSC1 3.4169 5.0868 0.4575 0.3871
LOU-NH91 GDSC1 3.4343 4.9202 0.5221 0.2279
NCI-H1755 GDSC1 3.4459 4.9131 0.5286 0.2115
NCI-H209 GDSC1 3.4471 11.5245 -2.3889 16.4522
PC-14 GDSC1 3.4483 5.2888 0.3971 0.5485
EKVX GDSC1 3.454 6.9326 -0.257 3.7819
SBC-3 GDSC1 3.4725 4.9485 0.526 0.209
HCC44 GDSC1 3.4903 5.3437 0.3936 0.5367
LC-1/sq GDSC1 3.4997 12.9417 -3.0377 19.3759
NCI-H2591 GDSC1 3.5223 5.5718 0.3227 0.7553
KNS-62 GDSC1 3.5241 5.2641 0.4349 0.4003
NCI-H1437 GDSC1 3.5355 5.4297 0.38 0.5544
NCI-H2818 GDSC1 3.54 5.5246 0.3472 0.6586
NCI-H1666 GDSC1 3.5461 8.5157 -0.9077 7.6781
HCC827 GDSC1 3.557 5.4895 0.3666 0.5848
NCI-H2291 GDSC1 3.563 5.4028 0.4002 0.4791
NCI-H1915 GDSC1 3.6027 5.0788 0.5274 0.1726
HARA [Human squamous cell lung carcinoma] GDSC1 3.6063 5.668 0.3209 0.7074
HOP-92 GDSC1 3.6141 5.9957 0.2011 1.1627
NCI-H2228 GDSC1 3.6207 5.7492 0.2967 0.7833
ABC-1 GDSC1 3.6302 5.4299 0.4159 0.4046
NCI-H1693 GDSC1 3.6386 5.2677 0.4756 0.2601
NCI-H513 GDSC1 3.6503 5.2891 0.4724 0.2632
NCI-H1836 GDSC1 3.6568 5.107 0.5366 0.146
NCI-H1869 GDSC1 3.6646 5.7442 0.316 0.688
NCI-H1944 GDSC1 3.6787 5.6246 0.3649 0.5251
NCI-H2731 GDSC1 3.6923 5.6218 0.3711 0.5001
NCI-H2009 GDSC1 3.6961 5.4246 0.442 0.3143
NCI-H596 GDSC1 3.6972 5.3307 0.4749 0.2437
NCI-H2087 GDSC1 3.6973 5.9669 0.2468 0.9145
NCI-H1838 GDSC1 3.718 6.0606 0.2201 1.002
NCI-H1048 GDSC1 3.7254 5.2375 0.5165 0.1624
Lu-135 GDSC1 3.7672 5.3358 0.4978 0.1831
PaCa-3 GDSC1 3.7952 5.7491 0.3646 0.4694
Calu-6 GDSC1 3.7958 5.2936 0.5219 0.1398
NCI-H2869 GDSC1 3.7978 5.6917 0.3859 0.4115
NCI-H2373 GDSC1 3.8054 5.5086 0.4524 0.2563
NCI-H661 GDSC1 3.8267 5.8266 0.349 0.4984
NCI-H1703 GDSC1 3.8308 5.6306 0.4194 0.3181
NCI-H2342 GDSC1 3.8618 5.8236 0.3632 0.4436
VMRC-LCD GDSC1 3.8821 5.3951 0.5175 0.13
EMC-BAC-2 GDSC1 3.9218 5.9339 0.3466 0.4615
NCI-H1623 GDSC1 3.9301 5.7603 0.4104 0.3044
NCI-H1688 GDSC1 3.9924 5.5632 0.499 0.1349
NCI-H2347 GDSC1 3.9963 6.127 0.306 0.5392
NCI-H211 GDSC1 4.0514 5.8345 0.4281 0.2335
ChaGo-K-1 GDSC1 4.0633 6.0982 0.3412 0.4162
HCC15 GDSC1 4.0633 11.1468 -1.8044 11.8914
EBC-1 GDSC1 4.0695 6.203 0.3066 0.5036
COLO 668 GDSC1 4.0766 5.9328 0.4034 0.2732
EPLC-272H GDSC1 4.0834 5.8348 0.4392 0.206
HCC366 GDSC1 4.0899 5.591 0.5228 0.0922
NCI-H647 GDSC1 4.1173 6.0213 0.3876 0.2927
DMS 53 GDSC1 4.1791 5.7721 0.4929 0.1123
NCI-H69 GDSC1 4.2521 18.2414 -5.0836 24.8575
NCI-H520 GDSC1 4.3153 6.0431 0.4492 0.144
Lu-99A GDSC1 4.3243 6.517 0.2906 0.4381
NCI-H2405 GDSC1 4.5198 6.7713 0.2734 0.4061
NCI-H1651 GDSC1 4.5249 6.1508 0.484 0.0786
SBC-1 GDSC1 4.9264 17.3002 -4.1556 20.4508
NCI-H322M GDSC1 5.9754 16.5115 -3.1058 14.3027
⏷ Show the Full List of 176 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.5212 5.4631 0.3622 0.6196
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 GDSC1 2.1716 3.5806 0.5059 1.1959
KYSE-510 GDSC1 2.551 4.2662 0.4072 1.2538
KYSE-150 GDSC1 2.5626 7.6454 -1.1278 11.4358
OE21 GDSC1 2.6615 8.1426 -1.2994 12.2855
COLO 680N GDSC1 2.7283 4.4387 0.4193 1.0028
TE-4 GDSC1 2.7351 4.9999 0.194 2.1939
OE19 GDSC1 2.7932 4.5953 0.3867 1.0914
KYSE-520 GDSC1 2.9131 5.2683 0.1706 2.0775
KYSE-180 GDSC1 3.0838 5.0271 0.346 1.001
KYSE-70 GDSC1 3.0993 5.1069 0.3219 1.0935
TE-11 GDSC1 3.2348 6.4082 -0.1471 3.4683
TE-5 GDSC1 3.2996 4.7511 0.532 0.2503
TE-6 GDSC1 3.3222 4.9533 0.4694 0.3977
KYSE-410 GDSC1 3.4122 5.2076 0.4125 0.52
T.T GDSC1 3.4596 5.1612 0.4472 0.3959
EC-GI-10 GDSC1 3.5478 5.0462 0.5192 0.2009
TE-1 GDSC1 3.6155 5.8329 0.2634 0.9106
TE-9 GDSC1 3.8195 5.3829 0.5001 0.1675
TE-10 GDSC1 3.8415 5.5251 0.4596 0.232
TE-8 GDSC1 3.8608 6.0291 0.2892 0.6611
OE33 GDSC1 3.9457 5.5284 0.4947 0.1496
TE-15 GDSC1 4.1348 6.2629 0.3098 0.4665
KYSE-140 GDSC1 4.2533 6.2772 0.3482 0.3319
KYSE-270 GDSC1 4.2947 6.333 0.3438 0.3278
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1 0.0813 3.1031 -0.8893 18.4994
OVCAR-3 GDSC1 1.6258 3.5209 0.2152 4.2561
TOV-21G GDSC1 2.1737 7.7345 -1.4462 14.6032
EFO-27 GDSC1 2.1813 7.3291 -1.2422 13.2614
OVK18 GDSC1 2.354 4.9536 0.0051 4.0825
TOV-112D GDSC1 2.3831 5.8385 -0.3866 6.7735
OVTOKO GDSC1 2.4076 6.5971 -0.7302 9.14
OVCAR-8 GDSC1 2.4181 4.2307 0.3574 1.7
JHOS-2 GDSC1 2.6533 4.695 0.2806 1.811
OVISE GDSC1 2.6534 10.5727 -2.488 19.0767
OV56 GDSC1 2.6567 3.9576 0.5718 0.4377
OAW42 GDSC1 2.8632 4.0624 0.6128 0.221
TYK-nu GDSC1 2.8898 5.9161 -0.1191 3.878
DOV13 GDSC1 2.9333 4.9118 0.3247 1.2436
OV-90 GDSC1 2.9903 5.8881 -0.0524 3.2845
OVKATE GDSC1 3.0836 4.7137 0.4637 0.543
FU-OV-1 GDSC1 3.1664 4.9196 0.4209 0.6394
OVCAR-4 GDSC1 3.1866 7.4483 -0.6356 6.676
OVCAR-5 GDSC1 3.2506 4.913 0.4565 0.471
SK-OV-3 GDSC1 3.2643 4.9011 0.466 0.4353
OC 314 GDSC1 3.2978 4.6402 0.5695 0.1755
JHOS-4 GDSC1 3.3749 5.0408 0.4581 0.4046
IGROV-1 GDSC1 3.4541 5.685 0.2519 1.0838
Kuramochi GDSC1 3.6355 5.3173 0.4573 0.301
ES-2 GDSC1 3.7599 5.1706 0.5506 0.1083
Caov-4 GDSC1 3.846 5.6912 0.4039 0.3483
EFO-21 GDSC1 3.8923 5.5051 0.4841 0.1767
OAW28 GDSC1 4.1789 7.3194 -0.066 1.828
RMG-I GDSC1 4.3055 6.2475 0.3769 0.2594
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAC GDSC1 1.6818 4.1684 -0.0582 6.1697
HPAF-II GDSC1 1.7263 3.4981 0.2919 3.4368
YAPC GDSC1 1.7566 3.807 0.1659 4.2893
MZ-PC-1 GDSC1 2.2463 4.8998 -0.0351 4.5936
PaTu 8988t GDSC1 2.3682 4.2278 0.3333 1.9159
PSN1 GDSC1 2.429 6.4668 -0.6539 8.5501
CFPAC-1 GDSC1 2.5816 4.7336 0.2282 2.2207
KP-2 GDSC1 2.6552 4.1069 0.5156 0.6483
Panc 02.03 GDSC1 2.698 4.8668 0.2312 2.0314
KP-4 GDSC1 2.7195 4.3215 0.4609 0.8236
SUIT-2 GDSC1 2.8835 4.4634 0.4759 0.6319
MIA PaCa-2 GDSC1 2.891 7.2606 -0.7297 7.9498
QGP-1 GDSC1 2.9272 10.0061 -2.0156 15.8367
Capan-1 GDSC1 2.9332 4.4567 0.4984 0.5175
Hs 766T GDSC1 2.9578 9.5786 -1.7876 14.4672
SW1990 GDSC1 3.0804 5.3117 0.2326 1.5387
SU.86.86 GDSC1 3.1528 4.5391 0.5523 0.2559
PL4 GDSC1 3.1913 5.0376 0.3872 0.7468
AsPC-1 GDSC1 3.2375 20.1118 -6.7613 31.1056
DAN-G GDSC1 3.3245 4.7472 0.5423 0.2203
PaTu 8902 GDSC1 3.468 4.8131 0.5702 0.1346
Panc 03.27 GDSC1 3.4958 5.1213 0.4746 0.3116
Panc 10.05 GDSC1 3.5548 5.2849 0.439 0.3764
HuP-T4 GDSC1 3.6151 5.4726 0.3951 0.4686
Capan-2 GDSC1 3.6834 5.6324 0.3639 0.5256
HuP-T3 GDSC1 3.6978 5.2758 0.4939 0.2073
BxPC-3 GDSC1 3.769 5.7525 0.3535 0.5132
KP-3 GDSC1 3.7703 6.1735 0.1993 1.0443
Panc 08.13 GDSC1 3.899 5.6524 0.4364 0.2603
Panc 04.03 GDSC1 4.0001 6.3194 0.238 0.7472
KP-1N GDSC1 4.1042 6.0996 0.3557 0.366
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1 2.192 4.8918 -0.0649 4.9276
NCI-H2052 GDSC1 2.6912 4.8734 0.225 2.0769
IST-Mes1 GDSC1 2.9679 4.7637 0.3975 0.8803
MPP 89 GDSC1 3.4685 5.3441 0.385 0.576
MSTO-211H GDSC1 3.5316 5.3057 0.423 0.4295
NCI-H2452 GDSC1 4.3031 6.1083 0.4232 0.1827
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 -3.5697 2.8999 -4.6097 54.2001
22Rv1 GDSC1 2.2104 4.1035 0.303 2.3636
VCaP GDSC1 3.3862 4.7283 0.5705 0.152
LNCaP clone FGC GDSC1 4.1856 6.0656 0.3966 0.2553
PC-3 GDSC1 4.2316 6.2943 0.3344 0.3694
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.2564 4.9677 0.439 0.5228
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-mel GDSC1 1.5934 3.3553 0.2726 3.9097
451Lu GDSC1 1.6079 3.3165 0.3008 3.662
GAK GDSC1 1.6219 2.8436 0.5305 1.9649
LB2518-MEL GDSC1 1.624 3.7748 0.092 5.1904
WM115 GDSC1 1.6942 5.1543 -0.5308 9.701
SK-MEL-28 GDSC1 1.7208 3.334 0.365 2.9201
A-388 GDSC1 1.737 3.7619 0.1744 4.2749
SK-MEL-5 GDSC1 1.8247 6.366 -1.0305 12.9051
LOX-IMVI GDSC1 1.849 4.6054 -0.1536 6.4307
SK-MEL-2 GDSC1 1.8737 2.9788 0.609 1.0192
SK-MEL-30 GDSC1 2.1591 3.4198 0.5655 0.8933
WM35 GDSC1 2.1666 4.0598 0.2981 2.4738
IGR-1 GDSC1 2.2609 3.7439 0.482 1.2113
CP50-MEL-B GDSC1 2.2632 4.6407 0.0935 3.6621
A2058 GDSC1 2.2801 3.8644 0.4416 1.4108
Hs 940.T GDSC1 2.2842 4.2131 0.2953 2.2853
CHL-1 GDSC1 2.2894 5.4321 -0.2558 6.065
COLO 679 GDSC1 2.3149 4.4676 0.2006 2.8422
UACC-62 GDSC1 2.3463 3.4373 0.6396 0.3992
IGR-37 GDSC1 2.3653 3.7627 0.5231 0.8785
A-431 GDSC1 2.399 4.4506 0.2539 2.3538
MMAc-SF GDSC1 2.4057 6.1058 -0.498 7.5086
SK-MEL-1 GDSC1 2.42 3.5527 0.6265 0.3975
MeWo GDSC1 2.5171 4.0001 0.4974 0.8473
VMRC-MELG GDSC1 2.5204 4.0239 0.4896 0.8804
HT-144 GDSC1 2.5937 4.7672 0.2202 2.2502
MZ-MEL-2 GDSC1 2.638 5.5676 -0.1063 4.2674
A101D GDSC1 2.6429 8.2287 -1.3537 12.6814
MZ-MEL-7 GDSC1 2.6607 4.1292 0.5095 0.6687
SK-MEL-3 GDSC1 2.6722 5.0195 0.1533 2.533
CP66-MEL GDSC1 2.7031 4.1663 0.5131 0.6213
WT2-iPS GDSC1 2.7228 3.9763 0.5908 0.3399
Mel Ho GDSC1 2.7388 4.8413 0.262 1.8006
HMV-II GDSC1 2.758 5.8298 -0.1549 4.3571
SK-MEL-24 GDSC1 2.7924 4.9295 0.2517 1.7867
SK-MEL-31 GDSC1 2.8729 4.5678 0.432 0.8152
Hs 938.T GDSC1 2.8993 4.3668 0.5179 0.4724
RPMI-7951 GDSC1 2.9 4.9244 0.3045 1.3787
LB373-MEL-D GDSC1 2.9193 4.1145 0.615 0.1967
IPC-298 GDSC1 3.0244 4.5613 0.4961 0.4709
COLO 783 GDSC1 3.0669 4.5478 0.5173 0.3834
COLO 792 GDSC1 3.1479 5.0809 0.3527 0.9176
A-375 GDSC1 3.1533 4.7594 0.4744 0.468
Mel JuSo GDSC1 3.1666 4.7849 0.4703 0.4735
M14 GDSC1 3.1754 4.7345 0.4918 0.4042
DJM-1 GDSC1 3.2371 6.0691 -0.0023 2.6101
UACC-257 GDSC1 3.3119 4.7469 0.5379 0.2335
G-361 GDSC1 3.3516 4.7661 0.5455 0.2059
COLO 829 GDSC1 3.5001 5.2792 0.4205 0.4513
RVH-421 GDSC1 3.5232 5.2519 0.4389 0.3903
SH-4 GDSC1 3.5732 5.8944 0.2225 1.1075
WM278 GDSC1 3.6661 5.7566 0.3121 0.7005
IST-MEL1 GDSC1 3.7259 5.6726 0.3657 0.4991
WM793 GDSC1 3.8265 5.4447 0.4816 0.1962
WM1552C GDSC1 3.8811 5.6852 0.4187 0.3026
COLO 800 GDSC1 5.2959 17.7985 -4.1452 19.6474
EquiPSC Line K2 GDSC1 4.0293 6.3432 0.2408 0.721
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 3.5316 5.1028 0.494 0.2556
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1 1.8493 3.9676 0.1502 4.177
VA-ES-BJ GDSC1 2.068 4.4719 0.0528 4.3693
Rh41 GDSC1 2.1116 3.4377 0.5356 1.1101
SK-LMS-1 GDSC1 2.1663 6.1407 -0.6752 9.3958
KYM-1 GDSC1 2.209 3.6437 0.498 1.1903
Rh18 GDSC1 2.3396 4.1238 0.3627 1.7834
SW684 GDSC1 2.4531 4.0716 0.4399 1.1991
Rh30 GDSC1 2.4728 5.111 0.0034 3.8546
G-402 GDSC1 2.7505 10.725 -2.492 18.8226
MES-SA GDSC1 2.7589 4.0622 0.5737 0.3727
GCT GDSC1 2.8476 4.5067 0.4446 0.7834
G-401 GDSC1 2.9807 5.4062 0.1467 2.1203
Hs 633.T GDSC1 3.1445 4.5478 0.5463 0.2732
SK-UT-1 GDSC1 3.2535 6.4635 -0.161 3.5224
HT-1080 GDSC1 3.271 4.8848 0.4744 0.4078
A-204 GDSC1 3.2756 9.175 -1.3822 11.245
SW872 GDSC1 3.3638 5.0451 0.4524 0.4259
RKN GDSC1 3.3797 4.8532 0.5256 0.2377
EW-8 GDSC1 3.4051 5.0437 0.4684 0.3633
STS-0421 GDSC1 4.0712 6.297 0.2737 0.5962
MFH-ino GDSC1 4.4728 16.0876 -3.8824 20.4567
RD GDSC1 5.6612 19.0212 -4.4847 20.0736
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN45 GDSC1 1.0647 1.8347 0.6353 2.6505
SNU-5 GDSC1 1.9385 3.422 0.4527 1.8773
HSC-39 GDSC1 2.0125 5.1968 -0.3263 7.2758
SNU-16 GDSC1 2.2337 6.1478 -0.6325 8.9086
Hs 746.T GDSC1 2.3011 4.4389 0.2056 2.8346
KATO III GDSC1 2.3698 4.7124 0.1229 3.2532
SCH GDSC1 2.5909 3.9772 0.5378 0.6095
ECC10 GDSC1 2.7359 14.7909 -4.5076 26.8
SNU-1 GDSC1 2.7504 5.8594 -0.1725 4.4891
SK-GT-2 GDSC1 2.9004 6.0944 -0.192 4.3311
23132/87 GDSC1 2.9571 4.2518 0.581 0.2612
TMK-1 GDSC1 2.9778 11.4844 -2.6992 19.2006
HGC-27 GDSC1 3.0062 6.3883 -0.263 4.5947
MKN7 GDSC1 3.0239 4.8455 0.39 0.8649
RF-48 GDSC1 3.1092 16.1312 -4.8878 26.9697
IM95 GDSC1 3.1676 5.4581 0.2142 1.5342
NUGC-4 GDSC1 3.2518 5.4268 0.2643 1.2105
NUGC-3 GDSC1 3.2627 4.8059 0.4993 0.3433
MKN1 GDSC1 3.2994 4.9792 0.4514 0.4608
GCIY GDSC1 3.4191 5.1982 0.4186 0.4978
AGS GDSC1 3.5254 5.1773 0.4659 0.3212
Fu97 GDSC1 3.614 5.1411 0.5102 0.1997
TGBC11TKB GDSC1 3.6246 5.2424 0.4793 0.2569
MKN28 GDSC1 3.7199 5.9034 0.2795 0.7794
OCUM-1 GDSC1 3.7356 5.4745 0.4391 0.3072
NCI-N87 GDSC1 4.007 6.2361 0.271 0.6379
RERF-GC-1B GDSC1 4.3113 6.8038 0.1835 0.7448
SNG-M GDSC1 3.1621 5.1876 0.3179 1.054
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-133 GDSC1 1.356 3.7509 -0.0912 7.3934
8505C GDSC1 1.9001 4.3743 -0.0089 5.2212
B-CPAP GDSC1 2.3498 10.3831 -2.6196 20.6038
CAL-62 GDSC1 2.8645 4.4528 0.4721 0.6604
ASH-3 GDSC1 2.9122 4.3485 0.5296 0.4271
CGTH-W-1 GDSC1 2.9159 4.4955 0.4771 0.6045
WRO GDSC1 2.9665 4.9398 0.3286 1.1911
BHT-101 GDSC1 3.0361 4.752 0.4305 0.6943
KMH-2 GDSC1 3.1246 4.7518 0.4659 0.5111
8305C GDSC1 3.1841 4.7635 0.4847 0.4205
ML-1 [Human leukemia] GDSC1 3.3015 5.0506 0.4264 0.5375
HTC-C3 GDSC1 3.4388 5.3008 0.3891 0.5796
IHH-4 GDSC1 3.4433 4.7175 0.5938 0.1065
TT GDSC1 3.4454 5.2574 0.4074 0.5181
K5 GDSC1 3.9053 5.4393 0.5107 0.135
TT2609-C02 GDSC1 4.0494 12.623 -2.5088 15.5902
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-38 GDSC1 0.4498 5.0199 -1.4851 20.9733
PCI-15A GDSC1 0.7266 3.6206 -0.5446 13.1628
SCC-15 GDSC1 1.7961 25.1478 -10.4171 39.0286
NCI-H3118 GDSC1 1.8465 4.0139 0.1266 4.3567
HO-1-N-1 GDSC1 1.9017 4.0755 0.133 4.177
JHU-029 GDSC1 2.0336 4.7213 -0.0859 5.455
SKN-3 GDSC1 2.0817 11.8587 -3.5563 25.41
OSC-20 GDSC1 2.1621 5.2006 -0.2288 6.179
BICR 22 GDSC1 2.2603 6.0208 -0.5537 8.2754
BHY GDSC1 2.3368 4.8361 0.0483 3.8217
PE/CA-PJ15 GDSC1 2.3377 17.9248 -6.3751 32.4335
Detroit 562 GDSC1 2.3744 4.511 0.2144 2.6462
HSC-3 GDSC1 2.4287 3.8365 0.5223 0.8181
FaDu GDSC1 2.5289 3.8929 0.5438 0.6344
BICR 78 GDSC1 2.5328 5.5083 -0.1411 4.7157
DOK GDSC1 2.5543 7.4165 -1.0235 10.764
BICR 10 GDSC1 2.6305 5.1615 0.0696 3.1267
PCI-06A GDSC1 2.661 7.7236 -1.0986 10.9822
CAL-27 GDSC1 2.7039 5.9588 -0.2445 5.0666
HSC-2 GDSC1 2.7856 3.9209 0.6338 0.2006
PCI-04B GDSC1 2.8344 6.4831 -0.4056 5.8846
HSC-4 GDSC1 2.8639 4.6013 0.4153 0.8941
SAT [Human HNSCC] GDSC1 2.9415 10.9121 -2.446 18.0649
SAS GDSC1 2.9802 8.4728 -1.243 11.1008
CAL-33 GDSC1 3.1577 5.0936 0.352 0.9124
OSC-19 GDSC1 3.2452 12.363 -2.9365 19.5811
UPCI-SCC-090 GDSC1 3.2558 5.1004 0.39 0.6911
BB49-HNC GDSC1 3.3939 5.4312 0.3229 0.8448
KON GDSC1 3.4328 5.4263 0.3406 0.7509
JHU-022 GDSC1 3.449 5.6744 0.2538 1.0803
PCI-30 GDSC1 3.4688 10.3293 -1.8024 13.255
HO-1-u-1 GDSC1 3.5049 5.3529 0.3959 0.5217
SCC-4 GDSC1 3.5645 5.2894 0.441 0.3671
LB771-HNC GDSC1 3.6443 5.4942 0.3984 0.4456
SCC-25 GDSC1 3.6577 5.2388 0.4923 0.2211
JHU-011 GDSC1 3.7575 11.3691 -2.1058 14.2253
SCC-9 GDSC1 3.7577 5.6631 0.3811 0.4415
BB30-HNC GDSC1 3.7753 5.6703 0.3851 0.4231
KOSC-2 GDSC1 4.0014 6.1912 0.2849 0.5984
Ca9-22 GDSC1 4.0507 5.9677 0.3821 0.3255
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 GDSC1 -0.2481 5.2259 -2.2258 28.3473
RT-4 GDSC1 1.9839 3.9509 0.2416 3.2174
KU-19-19 GDSC1 2.0003 3.4768 0.4624 1.7096
639V GDSC1 2.1755 3.4323 0.568 0.8615
BFTC-905 GDSC1 2.5206 4.1039 0.4581 1.0305
647V GDSC1 2.6283 4.1361 0.4931 0.7643
SW780 GDSC1 2.83 4.346 0.4979 0.5874
HT-1197 GDSC1 3.0484 4.453 0.544 0.3179
UM-UC-3 GDSC1 3.3782 4.9951 0.4755 0.3562
SW1710 GDSC1 3.383 5.1269 0.4304 0.4809
CAL-29 GDSC1 3.4266 5.1692 0.4319 0.4544
T24 GDSC1 3.4545 5.4891 0.326 0.7895
J82 GDSC1 3.5444 5.6872 0.2888 0.8656
TCCSUP GDSC1 3.606 5.0144 0.5502 0.1362
5637 GDSC1 3.6148 5.3843 0.4263 0.3841
HT-1376 GDSC1 3.6601 5.5092 0.399 0.4367
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa GDSC1 1.8582 4.2385 0.028 5.0544
ACC-OV7 GDSC1 2.1035 9.7793 -2.5073 20.8028
SKN GDSC1 2.2042 3.9105 0.3834 1.8674
ME-180 GDSC1 2.3802 5.9563 -0.4439 7.1879
DSH1 GDSC1 2.5803 4.7185 0.234 2.1882
LB831-BLC GDSC1 2.6006 4.552 0.314 1.6944
PWR-1E GDSC1 2.6724 5.0208 0.1528 2.5359
HEY GDSC1 2.7053 4.7598 0.2793 1.7484
HEC-1 GDSC1 2.7073 4.6205 0.3373 1.433
SW954 GDSC1 2.8158 4.567 0.4077 0.9718
NEC8 GDSC1 2.9277 4.3152 0.5476 0.3643
SW756 GDSC1 2.9607 4.5864 0.4615 0.6313
SKG-IIIa GDSC1 3.1067 4.5055 0.5472 0.2856
JEG-3 GDSC1 3.1534 4.3311 0.6237 0.1195
JAR GDSC1 3.1864 5.0945 0.3638 0.8417
C-4-I GDSC1 3.2766 4.7878 0.5108 0.3084
TC-YIK GDSC1 3.3 5.4304 0.2838 1.0804
SiHa GDSC1 3.3135 4.581 0.595 0.1295
SW962 GDSC1 3.3247 4.9786 0.4613 0.4192
OV17R GDSC1 3.3339 5.3767 0.3185 0.9077
NT2-D1 GDSC1 3.3572 5.1862 0.3989 0.5954
MS751 GDSC1 3.3764 4.9566 0.4884 0.3242
CAL-39 GDSC1 3.4409 5.35 0.3719 0.6355
OVCA420 GDSC1 3.4889 5.0302 0.5038 0.2488
PA-1 GDSC1 3.5353 5.1843 0.4671 0.3146
HT-3 GDSC1 3.7188 5.344 0.478 0.2313
BPH-1 GDSC1 3.7442 6.1057 0.214 1.0062
SiSo GDSC1 3.778 5.6853 0.3808 0.4333
OMC-1 [Human cervical carcinoma] GDSC1 3.7931 5.6157 0.4108 0.3516
DoTc2 4510 GDSC1 3.8305 5.6939 0.3973 0.3699
PEO1 GDSC1 3.8376 5.6711 0.4078 0.3423
OVCA433 GDSC1 3.8383 5.5715 0.4425 0.2662
JHOS-3 GDSC1 3.8494 5.7794 0.3742 0.4201
C-33 A GDSC1 3.9764 5.8268 0.4041 0.3027
OVMIU GDSC1 4.1003 6.0473 0.3725 0.3299
UWB1.289 GDSC1 4.2041 6.6993 0.1795 0.82
Ca Ski GDSC1 4.2106 6.513 0.2495 0.5976
KGN GDSC1 4.4396 6.3832 0.3778 0.2241
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6059).
2 Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41.