Details of the Drug

General Information of Drug (ID: DMKJY3U)

Drug Name
parathyroid hormone
Synonyms NPH-002; NPH-004; oral parathyroid hormone (osteoporosis), Nobex
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Affected Organisms
Humans and other mammals
ATC Code
H05AA03: parathyroid hormone
H05AA: Parathyroid hormones and analogues
H05A: PARATHYROID HORMONES AND ANALOGUES
H05: CALCIUM HOMEOSTASIS
H: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Sequence
SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLV
ESHEKSLGEADKADVNVLTKAKSQ
ADMET Property
Bioavailability
The bioavailability of drug is 55% []
Half-life
The concentration or amount of drug in body reduced by one-half in 1.5 hours [2]
Metabolism
The drug is metabolized via the liver []
Vd
The volume of distribution (Vd) of drug is 5.4 L []
Cross-matching ID
UNII
N19A0T0E5J
DrugBank ID
DB05829
TTD ID
D04PRM

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Parathyroid hormone (PTH) TT6F7GZ PTHY_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Parathyroid hormone (PTH) DTT PTH 3.70E-01 0.08 0.66
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure.J Bone Miner Res.2012 Aug;27(8):1811-20.
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds