Details of the Drug

General Information of Drug (ID: DMKT129)

Drug Name
Manganese
Synonyms
Colloidal manganese; Cutaval; MANGANESE COMPOUNDS; Magnacat; Mangan; Mangan [Polish]; Mangan nitridovany; Mangan nitridovany [Czech]; Manganese; Manganese element; Manganese fume; Manganese ion(4 ); Manganese metal alloy; Manganese(1-); Manganese(4 ); Manganese(7+); Manganese, 99+%, powder, -40 mesh; Manganese, elemental; Manganese, ion (Mn1-); Manganese, ion (Mn4 ); Manganese-55; Teprosyn M; Tronamang; manganeso; manganide; manganum
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 54.938
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 0
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 0
Chemical Identifiers
Formula
Mn
IUPAC Name
manganese
Canonical SMILES
[Mn]
InChI
InChI=1S/Mn
InChIKey
PWHULOQIROXLJO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
23930
ChEBI ID
ChEBI:18291
CAS Number
7439-96-5
UNII
H6EP7W5457
DrugBank ID
DB06757
VARIDT ID
DR00338

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Natural resistance-associated macrophage protein 2 (SLC11A2) DTVKMHD NRAM2_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) OTJISZOX PLCE1_HUMAN Gene/Protein Processing [2]
5,6-dihydroxyindole-2-carboxylic acid oxidase OTRK49R4 TYRP1_HUMAN Gene/Protein Processing [2]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) OTEZVTI1 DNPH1_HUMAN Gene/Protein Processing [2]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [3]
A-kinase anchor protein 7 isoforms alpha and beta (AKAP7) OT0L3PZ6 AKA7A_HUMAN Gene/Protein Processing [2]
Abl interactor 2 (ABI2) OT8GIIS5 ABI2_HUMAN Gene/Protein Processing [2]
Aconitate hydratase, mitochondrial (ACO2) OTF2UVNV ACON_HUMAN Gene/Protein Processing [4]
ADP-ribose pyrophosphatase, mitochondrial (NUDT9) OTUYF0H3 NUDT9_HUMAN Gene/Protein Processing [5]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Gene/Protein Processing [6]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Gene/Protein Processing [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009 Sep 8;48(35):8422-34.
2 Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells. Neurotoxicology. 2007 May;28(3):478-89.
3 Signaling pathways mediating manganese-induced toxicity in human glioblastoma cells (u87). Neurochem Res. 2006 Oct;31(10):1211-8. doi: 10.1007/s11064-006-9178-8. Epub 2006 Oct 17.
4 Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells. Asian J Androl. 2006 May;8(3):307-15. doi: 10.1111/j.1745-7262.2006.00139.x.
5 The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. Biochim Biophys Acta. 2006 Oct;1760(10):1545-51. doi: 10.1016/j.bbagen.2006.06.003. Epub 2006 Jun 9.
6 Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci Lett. 2008 Aug 8;440(3):344-7. doi: 10.1016/j.neulet.2008.05.070. Epub 2008 May 24.