Details of the Drug

General Information of Drug (ID: DMKWCTR)

Drug Name
GS-9973
Synonyms
Entospletinib; 1229208-44-9; GS-9973; Entospletinib (GS-9973); gs9973; UNII-6I3O3W6O3B; 6-(1H-Indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine; GS 9973; 6I3O3W6O3B; CHEMBL3265032; C23H21N7O; 6-(1H-Indazol-6-yl)-N-(4-(morpholin-4-yl)phenyl)imidazo(1,2-a)pyrazin-8-amine; Entospletinib [INN]; Entospletinib [USAN:INN]; 4puz; 6-(1h-Indazol-6-Yl)-N-[4-(Morpholin-4-Yl)phenyl]imidazo[1,2-A]pyrazin-8-Amine; GS-9973; Entospletinib; SCHEMBL2483776; GTPL7889; MolPort-035-395-879; HMS3653D13; EX-A1120; BCP09582; AOB87385
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 2 [1]
B-cell lymphoma 2A86 Phase 2 [2]
Haematological malignancy 2B33.Y Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 411.5
Logarithm of the Partition Coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C23H21N7O
IUPAC Name
6-(1H-indazol-6-yl)-N-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amine
Canonical SMILES
C1COCCN1C2=CC=C(C=C2)NC3=NC(=CN4C3=NC=C4)C5=CC6=C(C=C5)C=NN6
InChI
InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
InChIKey
XSMSNFMDVXXHGJ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
59473233
CAS Number
1229208-44-9
UNII
6I3O3W6O3B
DrugBank ID
DB12121
TTD ID
D0G9AW
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosine-protein kinase SYK (SYK) TTOU65C KSYK_HUMAN Modulator [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acute myeloid leukaemia
ICD Disease Classification 2A60
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine-protein kinase SYK (SYK) DTT SYK 5.20E-02 -0.57 -0.67
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.8816 6.2647 2.2869 5.0933
NOS-1 [Human HNSCC] GDSC2 1.2788 5.7157 0.1753 26.3902
ES8 GDSC2 2.1645 8.2914 -0.1829 24.6373
CHSA8926 GDSC2 2.3314 7.8477 0.1885 22.2237
CHSA0011 GDSC2 2.599 5.585 1.5431 13.5417
ES6 GDSC2 2.7283 9.5459 -0.2977 23.2204
U-CH2 GDSC2 3.178 5.6501 2.0358 8.5695
ES5 GDSC2 3.3433 8.4081 0.7966 15.6246
HOS GDSC2 3.4888 5.6901 2.2739 6.1654
SaOS-2 GDSC2 3.6969 11.0755 -0.247 20.0143
EW-12 GDSC2 3.7073 6.9993 1.7937 8.5966
CHSA0108 GDSC2 3.7232 6.0279 2.2871 5.4731
HuO-3N1 GDSC2 3.9296 17.9936 -3.5138 30.2803
NY GDSC2 3.94 14.0451 -1.5336 24.5879
SK-PN-DW GDSC2 3.9413 8.1143 1.4203 10.283
EW-11 GDSC2 3.994 10.4826 0.2851 16.563
EW-16 GDSC2 4.1704 11.919 -0.2916 18.9164
CAL-78 GDSC2 4.2323 13.1097 -0.8355 21.134
U2OS GDSC2 4.2446 9.9812 0.7265 13.5364
CAL-72 GDSC2 4.3956 11.834 -0.0758 17.3073
EW-1 GDSC2 4.4182 8.8508 1.4093 9.1862
EW-3 GDSC2 4.4397 10.454 0.6392 13.5248
EW-13 GDSC2 4.4598 6.7629 2.4318 3.0606
G-292 clone A141B1 GDSC2 4.5657 10.4694 0.7243 12.7516
A-673 GDSC2 4.5658 9.7227 1.0896 10.7039
TC-71 GDSC2 4.7134 10.7156 0.7108 12.4735
CADO-ES1 GDSC2 4.8823 6.9988 2.5633 1.7455
H-EMC-SS GDSC2 4.9193 10.4633 0.9789 10.5264
EW-24 GDSC2 4.9647 10.0334 1.2168 9.0906
ES7 GDSC2 5.0308 8.2129 2.1111 3.8896
EW-7 GDSC2 5.2404 7.2266 2.6428 1.026
EW-22 GDSC2 5.2519 7.6138 2.4911 1.657
MHH-ES-1 GDSC2 5.3804 11.8107 0.6463 11.3293
EW-18 GDSC2 5.4146 8.4976 2.1998 2.8552
SK-ES-1 GDSC2 5.687 7.1955 2.8352 0.2164
HuO9 GDSC2 5.8699 9.1474 2.1586 2.4896
ES4 GDSC2 6.8374 18.3959 -1.5246 17.9244
MG-63 GDSC2 7.1686 18.5093 -1.3546 16.668
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 157 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 5.3558 8.8717 2.0028 3.9617
SU-DHL-1 GDSC2 -1.1421 28.151 -12.9843 49.0389
MOLM-13 GDSC2 -0.5158 2.8684 -0.7517 39.4543
HT GDSC2 -0.45 90.4897 -43.4438 49.2697
SUP-B8 GDSC2 -0.1906 1.955 -0.2427 35.5005
SU-DHL-6 GDSC2 -0.0268 1.5781 -0.0416 33.6788
Kasumi-1 GDSC2 0.0613 2.307 -0.0195 33.1197
SU-DHL-5 GDSC2 0.209 1.3477 0.2065 31.2513
GA-10 GDSC2 0.2747 4.2236 -0.2872 33.2379
GDM-1 GDSC2 0.3108 4.7997 -0.4596 33.7742
P30/OHK GDSC2 0.5352 7.3675 -1.3205 35.6878
MLMA GDSC2 0.6584 8.3916 -1.671 36.1371
EoL-1 GDSC2 0.8402 5.0537 0.0019 29.1821
MC116 GDSC2 0.8558 18.3606 -6.34 42.4084
JVM-3 GDSC2 0.9531 8.1267 -1.2574 33.6535
SU-DHL-16 GDSC2 0.9889 6.1047 -0.293 29.8535
ML-2 GDSC2 1.0613 3.9629 0.6542 24.8464
CTB-1 GDSC2 1.0953 25.3445 -9.5959 43.8912
NALM-6 GDSC2 1.2467 8.0971 -0.9575 31.4039
BONNA-12 GDSC2 1.2666 5.7552 0.1454 26.5915
CESS GDSC2 1.3065 6.7767 -0.2785 28.4177
AMO1 GDSC2 1.3107 4.7626 0.6162 23.95
LAMA-84 GDSC2 1.3897 5.2477 0.4941 24.2699
Farage GDSC2 1.4169 4.7707 0.7244 22.9047
HAL-01 GDSC2 1.4466 7.2929 -0.3822 28.2946
RPMI-6666 GDSC2 1.4959 9.9741 -1.6262 32.6416
Loucy GDSC2 1.4972 4.1434 1.0585 20.6979
BC-1 GDSC2 1.5959 4.8832 0.864 21.377
Namalwa GDSC2 1.638 9.1725 -1.1028 30.3828
Jiyoye GDSC2 1.6414 9.3975 -1.2093 30.7441
DND-41 GDSC2 1.6987 5.8449 0.5418 22.7439
ALL-PO GDSC2 1.701 8.9633 -0.942 29.5555
697 GDSC2 1.7205 5.0454 0.9228 20.5344
SU-DHL-4 GDSC2 1.7323 5.2643 0.8382 20.9663
JVM-2 GDSC2 1.7492 6.245 0.4067 23.2674
RPMI-8866 GDSC2 1.8884 6.1803 0.5739 21.8237
RCH-ACV GDSC2 2.4856 7.4221 0.5391 19.8275
RL GDSC2 2.5213 38.0055 -14.6915 43.6119
A3/Kawakami GDSC2 2.5805 5.338 1.6448 12.9827
L-1236 GDSC2 2.6995 7.9945 0.4486 19.5908
EB2 GDSC2 2.9385 7.7571 0.7773 16.9848
KOPN-8 GDSC2 2.965 10.9703 -0.8036 24.6501
MOLM-16 GDSC2 2.9826 6.7941 1.2955 13.7844
OCI-Ly19 GDSC2 3.153 7.985 0.8482 15.9053
JeKo-1 GDSC2 3.1871 10.6962 -0.4781 22.5749
Ku812 GDSC2 3.2437 6.0465 1.8939 9.2664
DEL GDSC2 3.2767 5.9407 1.9747 8.659
VL51 GDSC2 3.3027 7.1734 1.3802 12.2878
ST486 GDSC2 3.3452 6.5008 1.7518 9.8597
SR GDSC2 3.3481 7.0776 1.4659 11.6281
RPMI-8226 GDSC2 3.4354 6.326 1.9134 8.5877
ARH-77 GDSC2 3.4876 7.2341 1.5021 11.0046
Raji GDSC2 3.5102 5.0507 2.609 3.9952
Karpas-299 GDSC2 3.5433 6.9904 1.6688 9.8171
HEL GDSC2 3.5443 7.4506 1.4398 11.2276
P12-Ichikawa GDSC2 3.5478 6.4787 1.9276 8.1863
CA46 GDSC2 3.6064 11.8482 -0.7065 22.3183
VAL GDSC2 3.6223 14.9569 -2.2472 27.7639
P32/ISH GDSC2 3.6356 6.6201 1.9264 7.958
CML-T1 GDSC2 3.6403 8.7047 0.891 14.225
JURL-MK1 GDSC2 3.6434 9.5614 0.4658 16.5835
BALL-1 GDSC2 3.6915 6.3832 2.0873 6.8037
OCI-AML-5 GDSC2 3.7444 8.0553 1.2974 11.5428
Karpas-422 GDSC2 3.7567 6.3714 2.1426 6.2922
SKM-1 GDSC2 3.7591 6.6851 1.9893 7.243
MEG-01 GDSC2 3.8066 7.65 1.5473 9.8588
NU-DUL-1 GDSC2 3.8123 7.7245 1.5148 10.0427
U-698-M GDSC2 3.8187 6.8394 1.9581 7.2874
OPM-2 GDSC2 3.8652 6.3364 2.24 5.4225
MY-M12 GDSC2 3.9285 8.1489 1.3935 10.4779
QIMR-WIL GDSC2 3.9299 8.6268 1.1576 11.8827
SUP-T1 GDSC2 3.931 8.3501 1.2957 11.0591
WSU-NHL GDSC2 3.937 6.7068 2.1107 6.0525
BL-41 GDSC2 3.9423 7.2711 1.8375 7.7279
Karpas-231 GDSC2 3.9573 5.8923 2.5199 3.5008
L-428 GDSC2 3.9995 10.6163 0.2229 16.8688
CCRF-CEM GDSC2 4.0018 10.9784 0.0445 17.7607
MHH-CALL-2 GDSC2 4.032 6.6343 2.2137 5.2003
SUP-HD1 GDSC2 4.0372 13.4067 -1.1375 22.862
NOMO-1 GDSC2 4.0377 7.9798 1.5593 9.1971
Jurkat GDSC2 4.0473 6.1822 2.4418 3.7831
SU-DHL-10 GDSC2 4.0642 6.6845 2.2119 5.1396
ALL-SIL GDSC2 4.0703 8.1134 1.5177 9.3689
DoHH2 GDSC2 4.0799 6.4885 2.3171 4.466
H9 GDSC2 4.0806 7.8179 1.6706 8.4148
Karpas-1106P GDSC2 4.1027 7.6868 1.7511 7.8703
IM-9 GDSC2 4.1065 6.0873 2.5257 3.1647
DB GDSC2 4.1212 6.8218 2.185 5.1775
OCI-AML-2 GDSC2 4.1339 11.0168 0.1285 16.9865
GR-ST GDSC2 4.1449 9.1198 1.077 11.8005
KMS-11 GDSC2 4.1627 8.5883 1.3524 10.1342
RS4;11 GDSC2 4.1637 7.9836 1.6499 8.341
Karpas-45 GDSC2 4.196 10.1489 0.6067 14.3188
PF-382 GDSC2 4.2013 8.7804 1.2863 10.4316
KMS-12-BM GDSC2 4.2036 9.388 0.9886 12.1622
KM-H2 GDSC2 4.2122 9.4568 0.9611 12.2979
TALL-1 [Human adult T-ALL] GDSC2 4.273 9.2249 1.1207 11.2266
U266B1 GDSC2 4.297 7.3325 2.0595 5.5582
L-363 GDSC2 4.3156 14.4941 -1.4592 23.3316
MOLP-8 GDSC2 4.3545 6.0435 2.6948 1.7887
LC4-1 GDSC2 4.3574 7.525 2.0082 5.7385
SCC-3 GDSC2 4.3585 5.7798 2.8115 1.1911
CRO-AP2 GDSC2 4.3911 7.2377 2.1673 4.7211
KE-37 GDSC2 4.3974 6.7505 2.3995 3.354
KCL-22 GDSC2 4.4019 7.494 2.0527 5.3797
Daudi GDSC2 4.4218 8.2399 1.7083 7.3975
SIG-M5 GDSC2 4.4248 12.2681 -0.2686 18.1441
MHH-PREB-1 GDSC2 4.4327 6.3752 2.5915 2.2225
L-540 GDSC2 4.4479 8.6034 1.5506 8.2802
MOLT-16 GDSC2 4.5084 8.5612 1.6131 7.7741
THP-1 GDSC2 4.5235 7.5526 2.1046 4.8301
Hs 445 GDSC2 4.5257 11.7604 0.0591 16.3188
Reh GDSC2 4.5614 9.6689 1.1127 10.5821
OCI-Ly7 GDSC2 4.5673 6.1348 2.7678 1.1515
JJN-3 GDSC2 4.5738 7.7706 2.0343 5.1436
EM-2 GDSC2 4.5758 6.4748 2.6271 1.8264
A4/Fukuda GDSC2 4.5818 10.835 0.5566 13.6207
Ramos.2G6.4C10 GDSC2 4.6266 11.4276 0.2984 14.8643
ME1 GDSC2 4.6515 6.5876 2.6187 1.7666
KY821 GDSC2 4.6671 8.6133 1.6959 6.945
BE-13 GDSC2 4.713 10.0529 1.0334 10.6837
HDLM-2 GDSC2 4.7252 8.1824 1.938 5.4122
HH [Human lymphoma] GDSC2 4.7581 7.191 2.4126 2.6844
PL-21 GDSC2 4.7707 10.0845 1.0587 10.4098
SUP-M2 GDSC2 4.7842 5.9423 2.9404 0.3201
KG-1 GDSC2 4.8004 8.1362 2.007 4.8729
K-562 GDSC2 4.8144 6.9717 2.5395 1.9485
CTV-1 GDSC2 4.8173 14.3454 -0.9986 20.3122
WIL2 NS GDSC2 4.8386 6.735 2.6522 1.3786
OCI-M1 GDSC2 4.8883 6.2193 2.8796 0.4417
NB4 GDSC2 4.8974 6.7601 2.6707 1.2326
TK [Human B-cell lymphoma] GDSC2 4.9149 6.8479 2.643 1.3373
ATN-1 GDSC2 4.9252 6.7925 2.6708 1.2036
MHH-CALL-4 GDSC2 4.941 7.24 2.4909 2.0256
OCI-AML-3 GDSC2 4.9771 11.8154 0.3632 13.6965
RC-K8 GDSC2 5.0099 6.452 2.8424 0.4848
JSC-1 GDSC2 5.0148 7.0867 2.5931 1.4538
HC-1 GDSC2 5.0368 7.093 2.6013 1.3938
TUR GDSC2 5.044 6.7435 2.7451 0.7956
EJM GDSC2 5.1139 7.2043 2.5928 1.3513
BC-3 GDSC2 5.1593 6.7511 2.7916 0.5539
MOLT-4 GDSC2 5.2326 6.7613 2.8177 0.4342
MM1.S GDSC2 5.2393 7.026 2.7207 0.7376
DG-75 GDSC2 5.2707 8.4717 2.1325 3.4031
Granta-519 GDSC2 5.3376 7.4098 2.6142 1.0553
SK-MM-2 GDSC2 5.3385 7.7523 2.4761 1.6316
Karpas-620 GDSC2 5.4275 6.9035 2.8418 0.2872
HL-60 GDSC2 5.4322 6.7374 2.9017 0.1684
ROS-50 GDSC2 5.4469 9.4135 1.8119 4.844
NK-92MI GDSC2 5.4826 8.4552 2.2537 2.5017
NCI-H929 GDSC2 5.495 16.6184 -1.6137 21.0501
MN-60 GDSC2 5.5193 7.4926 2.6614 0.7483
KMOE-2 GDSC2 5.5888 7.2913 2.7643 0.4063
SU-DHL-8 GDSC2 5.6105 7.3109 2.7656 0.3935
MOLT-13 GDSC2 5.6696 7.2501 2.8097 0.2709
LP-1 GDSC2 5.8153 7.2192 2.8726 0.1282
SUP-B15 GDSC2 6.0413 7.6987 2.7889 0.203
⏷ Show the Full List of 157 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC2 2.836 6.7851 1.1704 15.0122
FLO-1 GDSC2 2.8883 9.395 -0.0832 21.6883
OACM5.1 C GDSC2 3.337 10.2353 -0.1222 20.4774
TE-12 GDSC2 3.5487 8.3319 1.0033 13.8324
KYAE-1 GDSC2 3.9664 6.2698 2.3444 4.5474
OACP4 C GDSC2 4.7301 9.135 1.4887 8.0262
KYSE-50 GDSC2 5.0997 7.8219 2.3238 2.6547
ESO-51 GDSC2 5.3101 7.7852 2.4486 1.786
ESO-26 GDSC2 5.5934 14.4384 -0.4759 16.3023
HCE-4 GDSC2 6.0905 19.7479 -2.7135 23.3149
SK-GT-4 GDSC2 7.7175 25.0835 -4.1488 24.0049
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 3.7786 7.8429 1.4298 10.6503
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-N-RT-BM-1 GDSC2 1.269 4.4616 0.6926 23.7154
NB69 GDSC2 2.3662 10.6832 -1.1826 28.0645
SJNB-17 GDSC2 2.7341 19.9903 -5.5071 36.7734
SJNB-7 GDSC2 3.1478 9.1166 0.2782 19.0517
NB(TU)1 GDSC2 3.4694 10.4194 -0.1047 19.9987
CHP-212 GDSC2 4.0076 11.0429 0.0169 17.8814
KP-N-YS GDSC2 4.0431 7.0429 2.0228 6.345
SJNB-13 GDSC2 4.0791 9.2827 0.9467 12.7208
CHP-134 GDSC2 4.1878 5.9162 2.6557 2.2668
SJNB-10 GDSC2 4.3469 11.7113 -0.0522 17.3187
LA-N-6 GDSC2 4.4002 6.8899 2.3365 3.7123
MHH-NB-11 GDSC2 4.4706 10.6629 0.5592 13.8803
SK-N-BE(2)-M17 GDSC2 4.4785 7.0977 2.2888 3.843
SK-N-MC-IXC GDSC2 4.6254 6.1546 2.788 0.9986
Kelly GDSC2 4.6936 6.7685 2.5629 1.9924
SJNB-5 GDSC2 5.0692 12.5956 0.0483 15.0583
CHP-126 GDSC2 5.1959 7.0328 2.6992 0.8475
SiMa GDSC2 5.3439 7.5916 2.5444 1.3317
SK-N-DZ GDSC2 5.4108 9.145 1.9119 4.3622
IMR-5 GDSC2 5.4606 7.139 2.7696 0.4526
SK-N-AS GDSC2 5.5376 13.5838 -0.1004 14.7144
KP-N-YN GDSC2 5.5512 7.9803 2.4844 1.3862
SJNB-6 GDSC2 5.6289 7.2708 2.7871 0.3346
GOTO GDSC2 5.6761 8.711 2.2443 2.3144
NH-12 GDSC2 5.6813 7.6706 2.6616 0.6472
TGW GDSC2 5.7868 11.3077 1.1485 7.8501
SJNB-14 GDSC2 5.8625 7.6591 2.7371 0.3591
GI-ME-N GDSC2 6.2679 10.5953 1.7476 3.9678
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.0146 7.4861 1.7851 7.8733
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC2 1.6098 5.4241 0.6424 22.554
HCC1599 GDSC2 3.262 12.223 -1.1787 25.2126
MDA-MB-231 GDSC2 3.4008 5.1406 2.4775 5.1217
Evsa-T GDSC2 3.5137 10.2539 0.0144 19.2877
HCC1954 GDSC2 3.7333 6.9718 1.8275 8.3188
CAL-51 GDSC2 3.7942 5.6096 2.5438 3.7117
BT-20 GDSC2 3.8594 7.5515 1.6366 9.1739
CAL-85-1 GDSC2 3.9092 8.2911 1.3082 11.041
CAL-120 GDSC2 4.0275 9.8827 0.6094 14.7458
MDA-MB-468 GDSC2 4.0453 8.3225 1.3959 10.166
T-47D GDSC2 4.0776 6.7952 2.1676 5.3798
HCC70 GDSC2 4.1007 8.8236 1.1901 11.2509
Hs 578T GDSC2 4.1937 9.5456 0.9034 12.6735
HCC1428 GDSC2 4.3766 6.8233 2.3527 3.6618
HCC1569 GDSC2 4.3867 8.8713 1.3768 9.4515
BT-474 GDSC2 4.4684 7.1622 2.2524 4.0726
BT-549 GDSC2 4.5275 9.3849 1.227 10.0014
HCC2218 GDSC2 4.594 6.985 2.4105 2.954
HCC1500 GDSC2 4.6356 8.3791 1.7865 6.4769
HCC1419 GDSC2 4.658 7.5797 2.1767 4.1603
HCC1937 GDSC2 4.7758 9.2195 1.4791 7.985
HCC2157 GDSC2 4.8786 6.7933 2.6478 1.3548
HDQ-P1 GDSC2 4.9261 7.338 2.4406 2.2973
JIMT-1 GDSC2 4.9529 6.5078 2.797 0.6755
MCF-7 GDSC2 4.9724 8.1078 2.1244 3.9122
MDA-MB-361 GDSC2 4.987 11.2243 0.6577 12.1294
AU565 GDSC2 5.0493 9.8528 1.3596 8.1046
UACC-893 GDSC2 5.1171 14.1988 -0.7026 18.37
MDA-MB-157 GDSC2 5.222 9.3576 1.7023 5.8344
CAMA-1 GDSC2 5.2777 12.9129 0.0425 14.6096
ZR-75-30 GDSC2 5.2916 14.9544 -0.9456 18.9721
EFM-192A GDSC2 5.2936 6.8825 2.7974 0.4601
HCC1143 GDSC2 5.3814 13.7313 -0.2822 15.9051
MDA-MB-453 GDSC2 5.4016 7.9636 2.4197 1.8169
MDA-MB-415 GDSC2 5.613 7.3052 2.7687 0.3848
MDA-MB-436 GDSC2 5.6478 7.5847 2.6799 0.6107
MDA-MB-330 GDSC2 5.742 15.0932 -0.6891 16.8988
OCUB-M GDSC2 5.7648 7.9643 2.5854 0.8391
COLO 824 GDSC2 5.7946 8.0767 2.5551 0.9218
HCC1187 GDSC2 5.8357 7.5926 2.7506 0.3387
MRK-nu-1 GDSC2 5.8481 7.135 2.912 0.0782
EFM-19 GDSC2 5.8532 14.3178 -0.2362 14.6657
HCC38 GDSC2 5.986 9.0968 2.2366 2.0126
YMB-1-E GDSC2 6.551 8.7415 2.6116 0.3847
HCC1806 GDSC2 6.7372 14.378 0.3146 10.3644
MFM-223 GDSC2 7.0989 15.3399 0.093 10.7669
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-336MG GDSC2 1.6311 13.4911 -3.2325 36.1022
D-423MG GDSC2 2.3847 4.9366 1.6439 13.7003
D-502MG GDSC2 2.4712 5.0556 1.6735 13.2004
SNB-75 GDSC2 2.8981 4.8013 2.2049 8.4094
SF539 GDSC2 2.9238 9.0988 0.0953 20.695
D-566MG GDSC2 3.216 4.3905 2.6969 4.2764
KS-1 [Human Krukenberg tumour] GDSC2 3.3071 9.1261 0.4074 17.8827
42-MG-BA GDSC2 3.3644 8.8497 0.5934 16.7019
D-245MG GDSC2 3.404 6.6975 1.702 10.0019
YKG-1 GDSC2 3.4192 5.1652 2.48 5.0544
D-392MG GDSC2 3.4825 12.8276 -1.2978 25.0109
NMC-G1 GDSC2 3.5662 6.4011 1.9808 7.8023
LN-18 GDSC2 3.5853 8.2263 1.0856 13.2455
GI-1 GDSC2 3.657 6.6632 1.9216 7.9312
AM-38 GDSC2 3.6869 7.5079 1.5248 10.3152
H4 GDSC2 3.7445 15.5497 -2.4435 28.009
Onda 10 GDSC2 3.7712 6.2561 2.2104 5.8335
SF126 GDSC2 3.7719 6.7759 1.9541 7.4303
8-MG-BA GDSC2 3.8665 10.3294 0.261 17.0366
KALS-1 GDSC2 3.9123 7.834 1.537 9.6486
PFSK-1 GDSC2 3.9363 9.6284 0.6649 14.6852
YH-13 GDSC2 3.9574 6.1701 2.3864 4.3109
SF268 GDSC2 4.0131 6.5897 2.2221 5.1912
T98G GDSC2 4.0978 7.4124 1.8817 7.083
U-87MG ATCC GDSC2 4.1987 7.7337 1.7971 7.3648
M059J GDSC2 4.2058 7.0438 2.1361 5.2911
LN-405 GDSC2 4.2952 8.4038 1.5393 8.6981
LN-229 GDSC2 4.3276 6.9857 2.2451 4.3873
D283 Med GDSC2 4.3409 8.4761 1.5368 8.6066
D-247MG GDSC2 4.3859 8.3377 1.6359 7.9106
KINGS-1 GDSC2 4.4379 10.5138 0.6084 13.6963
D-542MG GDSC2 4.46 11.063 0.3541 14.9897
U-118MG GDSC2 4.4724 7.9761 1.8698 6.3234
DK-MG GDSC2 4.5224 7.6109 2.0764 4.9977
SK-MG-1 GDSC2 4.5597 8.3135 1.7671 6.7497
KNS-81-FD GDSC2 4.6491 11.2046 0.4245 14.1562
CAS-1 GDSC2 4.7349 8.8048 1.6498 7.0749
D-263MG GDSC2 4.7405 6.5791 2.6685 1.415
A-172 GDSC2 4.7738 10.599 0.8109 11.7849
Daoy GDSC2 4.8647 12.2732 0.0578 15.4937
KNS-42 GDSC2 4.885 6.6345 2.716 1.05
GaMG GDSC2 4.8872 10.8758 0.7566 11.822
Becker GDSC2 5.1582 9.826 1.4433 7.4132
SF295 GDSC2 5.1903 6.9325 2.7356 0.7204
ONS-76 GDSC2 5.2179 10.4377 1.1929 8.6999
Onda 11 GDSC2 5.2298 8.1615 2.2463 2.871
Hs 683 GDSC2 5.3528 14.4465 -0.652 17.6078
U-251MG GDSC2 5.3666 7.1227 2.7376 0.5983
GB-1 GDSC2 5.7318 14.2379 -0.2816 15.1312
SW1088 GDSC2 5.9331 11.9164 0.9569 8.5987
DBTRG-05MG GDSC2 6.0353 15.5177 -0.6895 16.2738
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 3.9885 9.7779 0.6313 14.7303
TGBC24TKB GDSC2 4.9803 12.1904 0.1823 14.6046
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 2.6268 7.001 0.8753 17.449
KLE GDSC2 3.6928 10.7136 -0.0696 19.1808
EN GDSC2 4.2001 8.6216 1.3636 9.9757
AN3-CA GDSC2 4.3654 15.0242 -1.6839 23.9986
MFE-280 GDSC2 4.5089 8.7347 1.5296 8.268
RL95-2 GDSC2 5.2495 10.2652 1.2953 8.0656
MFE-296 GDSC2 5.3166 8.3345 2.2179 2.8963
MFE-319 GDSC2 5.5303 6.9413 2.8666 0.2037
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 GDSC2 1.004 7.3189 -0.8299 31.957
NCC021 GDSC2 2.1752 6.2344 0.8265 19.3269
KTCTL-140 GDSC2 2.5435 4.3804 2.0576 10.5992
KTCTL-13 GDSC2 2.8348 5.9901 1.5629 12.6197
Caki-1 GDSC2 2.8574 7.8873 0.6414 18.0128
A-498 GDSC2 2.9436 9.5819 -0.1287 21.7292
A-704 GDSC2 3.0735 6.1 1.7208 10.8721
KTCTL-26A GDSC2 3.0875 5.6782 1.9432 9.4327
RXF 393L GDSC2 3.1996 9.2608 0.2499 19.0386
SW13 GDSC2 3.4813 7.5413 1.3436 11.9932
UO-31 GDSC2 3.485 6.3759 1.9286 8.3529
KTCTL-1M GDSC2 3.5481 5.8453 2.2434 6.198
KTCTL-195 GDSC2 3.7292 8.8011 0.9139 13.8449
OS-RC-2 GDSC2 3.8973 13.5975 -1.3446 24.0222
NCC010 GDSC2 3.8988 8.3699 1.2611 11.3499
ACHN GDSC2 3.9461 11.0301 -0.0251 18.2556
786-O GDSC2 3.952 9.2759 0.8524 13.5923
BFTC-909 GDSC2 3.9653 6.5565 2.2045 5.4079
KMRC-20 GDSC2 4.283 10.978 0.2624 15.9148
LB1047-RCC GDSC2 4.368 11.431 0.1028 16.503
HA7-RCC GDSC2 4.4469 9.6646 1.0322 11.3135
SN12C GDSC2 4.7255 8.8134 1.6395 7.1549
VMRC-RCW GDSC2 4.7574 7.0214 2.4872 2.2928
LB2241-RCC GDSC2 4.8089 8.1502 2.0058 4.8639
BB65-RCC GDSC2 4.8377 8.9697 1.6393 6.9264
769-P GDSC2 4.8645 9.3592 1.4719 7.841
RCC10RGB GDSC2 5.0516 6.5286 2.8308 0.496
VMRC-RCZ GDSC2 5.0548 8.4504 2.0175 4.366
TK-10 GDSC2 5.2466 13.1135 -0.0773 15.2551
SW156 GDSC2 5.3813 7.6975 2.5191 1.4022
LB996-RCC GDSC2 5.4483 8.2264 2.3331 2.1638
KTCTL-21 GDSC2 5.9133 15.1649 -0.6037 16.1662
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KM12 GDSC2 0.2372 3.3831 -0.0615 32.415
HT-55 GDSC2 2.8239 5.9137 1.5907 12.4837
C2BBe1 GDSC2 2.8316 8.0673 0.5292 18.7173
HCT 15 GDSC2 2.9865 9.379 0.0095 20.9212
HCT 116 GDSC2 3.6034 5.075 2.6675 3.3934
RKO GDSC2 3.6973 7.9126 1.3314 11.4656
LS411N GDSC2 3.7041 10.7943 -0.1008 19.2995
LS180 GDSC2 3.7782 6.6713 2.0106 7.0622
DiFi GDSC2 3.8905 7.9026 1.4865 10.0123
SW626 GDSC2 3.8922 8.8367 1.0242 12.7645
SW1417 GDSC2 3.9721 9.6732 0.6706 14.5576
SW1463 GDSC2 3.9829 6.5924 2.1994 5.3987
NCI-H716 GDSC2 4.0194 8.0433 1.5143 9.5158
SNU-175 GDSC2 4.1897 13.0513 -0.8399 21.2647
CCK-81 GDSC2 4.2022 12.1541 -0.3837 19.2545
MDST8 GDSC2 4.2305 6.8312 2.2545 4.5273
SW948 GDSC2 4.3352 6.0885 2.664 1.9821
CW-2 GDSC2 4.3778 7.6401 1.9668 5.9433
SW48 GDSC2 4.3789 7.2355 2.1603 4.7868
COLO205 GDSC2 4.4894 9.816 0.989 11.4582
HT-29 GDSC2 4.516 9.4785 1.1732 10.3397
GP5d GDSC2 4.521 10.2663 0.7913 12.4908
LS123 GDSC2 4.5453 7.2227 2.2723 3.8162
CaR-1 GDSC2 4.5503 8.7224 1.5642 7.9715
SNU-1040 GDSC2 4.6145 6.3925 2.683 1.4971
SW1116 GDSC2 4.649 7.2535 2.3211 3.3595
COLO 678 GDSC2 4.7166 7.8222 2.1006 4.4897
CL-11 GDSC2 4.7436 10.6861 0.7469 12.2059
SNU-61 GDSC2 4.749 10.0557 1.0574 10.4662
HT115 GDSC2 4.7866 7.0479 2.4915 2.2294
SNU-407 GDSC2 4.7914 8.5143 1.8245 5.9432
SNU-C5 GDSC2 4.8673 12.7138 -0.1566 16.5188
SNU-C1 GDSC2 4.8726 7.8086 2.2013 3.6524
SNU-81 GDSC2 4.9069 8.1433 2.0691 4.3304
HCC2998 GDSC2 4.9242 11.4682 0.4946 13.1368
LoVo GDSC2 4.9562 10.1413 1.1593 9.4337
NCI-H747 GDSC2 4.9585 7.7556 2.2747 3.1172
LS513 GDSC2 5.0481 7.287 2.5261 1.7248
LS1034 GDSC2 5.0747 6.8088 2.7332 0.8159
RCM-1 [Human ESC] GDSC2 5.2046 13.5327 -0.3122 16.4452
SNU-283 GDSC2 5.223 6.764 2.8129 0.4531
T84 GDSC2 5.3931 8.1312 2.3452 2.1719
SK-CO-1 GDSC2 5.5222 7.4693 2.6714 0.7133
NCI-H508 GDSC2 5.6328 7.4987 2.7058 0.543
COLO 320HSR GDSC2 5.8387 7.6912 2.7165 0.4171
SW837 GDSC2 5.902 20.5049 -3.2256 25.1273
SNU-C2B GDSC2 6.1132 14.9019 -0.3394 14.5919
SW620 GDSC2 7.5266 15.4828 0.2854 9.1797
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 5.3734 7.0098 2.7824 0.461
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC2 1.1883 4.6906 0.5162 25.0193
Hep 3B2.1-7 GDSC2 2.5053 6.6014 0.9602 17.3721
HuH-1 GDSC2 2.9243 7.4723 0.9068 16.285
JHH-4 GDSC2 3.6024 14.7129 -2.1416 27.5008
HLE GDSC2 3.8428 9.1293 0.8401 13.9563
Huh-7 GDSC2 3.8747 7.1549 1.8444 7.8529
SNU-423 GDSC2 3.9558 9.7571 0.6161 14.9013
JHH-7 GDSC2 4.1125 7.3486 1.9234 6.7938
Hep-G2/C3A GDSC2 4.1421 6.8545 2.1836 5.1405
SNU-387 GDSC2 4.3293 11.326 0.1253 16.49
JHH-2 GDSC2 4.629 10.2046 0.8998 11.6296
SNU-449 GDSC2 4.9968 9.9141 1.2955 8.5767
JHH-6 GDSC2 5.2391 15.2053 -1.1075 19.7397
SK-HEP-1 GDSC2 5.4612 12.2996 0.4665 12.0916
JHH-1 GDSC2 5.6494 6.8997 2.9227 0.0948
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 166 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H322M GDSC2 1.4684 9.6194 -1.4792 32.2918
NCI-H2795 GDSC2 1.5165 7.4274 -0.378 27.9936
CAL-12T GDSC2 2.1647 8.6466 -0.3572 25.4336
NCI-H647 GDSC2 2.6413 5.182 1.7778 11.9499
NCI-H1975 GDSC2 2.6743 7.1914 0.8241 17.5838
A-549 GDSC2 2.8915 11.2565 -1.0095 25.7011
NCI-H1568 GDSC2 2.9085 13.9515 -2.3412 30.0494
LXF 289 GDSC2 2.9128 13.3394 -2.0317 29.1379
EMC-BAC-2 GDSC2 2.9261 9.7338 -0.2196 22.2155
NCI-H650 GDSC2 2.9714 5.5644 1.8966 10.0944
NCI-H2023 GDSC2 3.235 6.5745 1.6226 10.9916
LOU-NH91 GDSC2 3.2703 8.1022 0.8886 15.315
NCI-H460 GDSC2 3.2826 4.471 2.7143 3.963
NCI-H1651 GDSC2 3.288 11.1062 -0.5985 22.7948
NCI-H838 GDSC2 3.3047 6.0591 1.939 8.8016
NCI-H290 GDSC2 3.3202 5.7571 2.1029 7.7222
NCI-H1793 GDSC2 3.385 10.8508 -0.3901 21.5826
PC-14 GDSC2 3.4514 8.8082 0.6859 15.9306
LCLC-103H GDSC2 3.4858 6.9359 1.6497 10.0959
HCC366 GDSC2 3.4981 9.7492 0.2539 18.1221
Ms-1 GDSC2 3.54 7.0959 1.6134 10.1699
NCI-H2170 GDSC2 3.6154 6.9143 1.7641 9.0264
SBC-5 GDSC2 3.6585 6.5255 1.9912 7.4913
KNS-62 GDSC2 3.689 10.5245 0.0218 18.7441
COR-L303 GDSC2 3.7084 9.3009 0.6481 15.4047
LC-2/ad GDSC2 3.7146 6.5982 1.9985 7.3
SBC-3 GDSC2 3.7151 7.8511 1.376 11.147
BEN GDSC2 3.7158 9.5331 0.5381 15.9876
EPLC-272H GDSC2 3.7788 8.9286 0.8896 13.8482
NCI-H3255 GDSC2 3.787 7.7704 1.4724 10.3681
NCI-H1755 GDSC2 3.7886 20.2781 -4.7704 33.147
NCI-H2196 GDSC2 3.8444 6.1618 2.3103 5.0358
NCI-H292 GDSC2 3.8566 7.1388 1.8387 7.9336
NCI-H82 GDSC2 3.8957 6.4922 2.1858 5.6857
NCI-H720 GDSC2 3.9075 8.0074 1.4475 10.205
NCI-H2122 GDSC2 3.9129 8.3524 1.2806 11.1962
NCI-H1155 GDSC2 3.9357 6.0307 2.4387 4.0397
Lu-134-A GDSC2 3.9457 10.1362 0.4196 15.9888
HARA [Human squamous cell lung carcinoma] GDSC2 3.9551 7.7907 1.5907 9.2118
NCI-H2373 GDSC2 3.9788 9.4127 0.8051 13.7886
NCI-H2081 GDSC2 3.9846 8.6573 1.1844 11.5816
SHP-77 GDSC2 3.9852 12.1298 -0.5422 20.5471
RERF-LC-KJ GDSC2 3.9987 7.9497 1.545 9.3816
NCI-H596 GDSC2 4.0054 6.9754 2.0287 6.3969
NCI-H1993 GDSC2 4.0279 7.9258 1.5786 9.1037
NCI-H2444 GDSC2 4.0889 5.7445 2.6745 2.3324
NCI-H2110 GDSC2 4.1219 8.7613 1.2368 10.9219
NCI-H358 GDSC2 4.15 12.3028 -0.4984 19.9081
NCI-H2085 GDSC2 4.1785 11.1631 0.0903 17.0594
NCI-H2803 GDSC2 4.1952 7.4958 1.9104 6.6842
SW1271 GDSC2 4.1952 10.0391 0.6605 14.0265
NCI-H526 GDSC2 4.2024 9.4977 0.9336 12.4798
HOP-92 GDSC2 4.2225 9.4891 0.9529 12.3186
SK-LU-1 GDSC2 4.2255 11.2532 0.0819 16.9775
NCI-H1437 GDSC2 4.238 7.3684 2.0019 6.0328
NCI-H146 GDSC2 4.2409 7.2843 2.0444 5.7693
RERF-LC-MS GDSC2 4.2484 10.0479 0.6964 13.6926
NCI-H2029 GDSC2 4.2537 8.3293 1.5459 8.7558
Calu-3 GDSC2 4.2803 13.5482 -1.0161 21.7404
LCLC-97TM1 GDSC2 4.2963 9.1634 1.1681 10.8936
COR-L23 GDSC2 4.3151 6.3034 2.5551 2.6147
COLO 668 GDSC2 4.3177 8.1689 1.6698 7.8622
NCI-H2461 GDSC2 4.3229 8.166 1.6749 7.8192
A-427 GDSC2 4.3299 9.5322 1.0115 11.7165
NCI-H2804 GDSC2 4.3507 8.7528 1.4088 9.3463
NCI-H1694 GDSC2 4.377 6.0689 2.6961 1.7493
NCI-H1092 GDSC2 4.3895 6.3261 2.5886 2.3057
NCI-H1781 GDSC2 4.4178 13.0762 -0.6748 19.974
Lu-165 GDSC2 4.4194 8.0128 1.8161 6.7574
HCC827 GDSC2 4.4198 6.4448 2.5528 2.4537
NCI-H2171 GDSC2 4.431 7.8209 1.9161 6.1343
NCI-H1915 GDSC2 4.4375 10.3102 0.7083 13.1526
NCI-H2228 GDSC2 4.4747 10.8987 0.4461 14.4717
CPC-N GDSC2 4.4913 12.1554 -0.1621 17.4749
NCI-H1355 GDSC2 4.4953 13.611 -0.8804 20.637
NCI-H2227 GDSC2 4.5044 6.451 2.5983 2.0776
NCI-H1792 GDSC2 4.5209 10.4889 0.6819 13.0926
EMC-BAC-1 GDSC2 4.5493 8.0883 1.8676 6.1757
HCC78 GDSC2 4.5587 16.1406 -2.0881 24.8553
HCC44 GDSC2 4.5707 10.089 0.9142 11.6864
NCI-H2731 GDSC2 4.618 7.9025 2.0007 5.2545
NCI-H2810 GDSC2 4.6267 9.6308 1.1776 10.0584
SBC-1 GDSC2 4.6299 6.7151 2.5515 2.1406
NCI-H1734 GDSC2 4.6461 7.1715 2.3567 3.1663
SK-MES-1 GDSC2 4.6655 7.608 2.1682 4.1952
NCI-H2172 GDSC2 4.6679 8.1147 1.933 5.5524
NCI-H345 GDSC2 4.7052 5.7687 2.9728 0.271
NCI-H209 GDSC2 4.7196 13.4519 -0.6306 19.0213
Lu-65 GDSC2 4.7352 10.0632 1.0442 10.5724
NCI-H1666 GDSC2 4.7401 11.2993 0.4445 13.8319
NCI-H1435 GDSC2 4.7576 7.8099 2.1316 4.2389
Lu-135 GDSC2 4.759 6.9914 2.5012 2.218
NCI-H727 GDSC2 4.7599 11.6766 0.274 14.6652
HCC33 GDSC2 4.7666 7.0974 2.4588 2.4278
NCI-H2369 GDSC2 4.7734 10.0257 1.089 10.2324
IA-LM GDSC2 4.7796 9.6303 1.2844 9.1032
DMS 114 GDSC2 4.801 7.1747 2.4438 2.4566
EBC-1 GDSC2 4.8406 10.4069 0.9514 10.8548
NCI-H841 GDSC2 4.8805 9.4921 1.4191 8.1119
NCI-H2291 GDSC2 4.8891 7.1732 2.4922 2.0868
NCI-H748 GDSC2 4.8939 8.8375 1.7383 6.2422
DMS 273 GDSC2 4.9069 17.1199 -2.3048 24.6962
NCI-H226 GDSC2 4.9208 16.1536 -1.815 23.0795
NCI-H1944 GDSC2 4.9446 10.3523 1.0499 10.0739
NCI-H513 GDSC2 4.9542 13.333 -0.3969 17.4185
NCI-H196 GDSC2 4.955 8.6675 1.8566 5.4485
DMS 79 GDSC2 4.9646 7.1999 2.5203 1.8523
NCI-H1836 GDSC2 4.977 7.3656 2.4559 2.1526
NCI-H2087 GDSC2 4.9807 7.1 2.5706 1.5947
NCI-H23 GDSC2 4.9816 11.1417 0.6939 11.947
NCI-H1650 GDSC2 4.9857 17.6922 -2.5281 25.1846
NCI-H2141 GDSC2 4.9905 7.3024 2.49 1.967
ABC-1 GDSC2 5.0055 11.7693 0.4059 13.4112
Calu-6 GDSC2 5.013 12.1964 0.2029 14.4258
NCI-H661 GDSC2 5.0208 7.3289 2.4944 1.9081
COR-L321 GDSC2 5.0387 6.9444 2.6628 1.1262
Lu-139 GDSC2 5.0612 7.5212 2.4334 2.1552
NCI-H1869 GDSC2 5.0883 12.8146 -0.045 15.4647
NCI-H740 GDSC2 5.0983 8.1639 2.1721 3.4524
NCI-H1623 GDSC2 5.1505 9.3101 1.6799 6.0899
NCI-H1105 GDSC2 5.1616 6.8975 2.7367 0.7372
NCI-H2595 GDSC2 5.1774 9.6992 1.5152 6.9699
IST-SL2 GDSC2 5.182 11.0639 0.87 10.5548
NCI-H2030 GDSC2 5.1834 16.953 -2.0113 23.12
NCI-H1581 GDSC2 5.1966 10.8826 0.9667 9.9956
VMRC-LCD GDSC2 5.214 7.7694 2.4068 2.0938
DMS 53 GDSC2 5.2317 7.5678 2.5002 1.6379
NCI-H1563 GDSC2 5.2435 13.5578 -0.2963 16.2831
NCI-H2135 GDSC2 5.2458 6.6499 2.8634 0.3084
NCI-H2869 GDSC2 5.2893 12.6928 0.1576 14.0212
NCI-H2818 GDSC2 5.2997 9.5049 1.682 5.8085
NCI-H211 GDSC2 5.2999 7.6409 2.5033 1.5518
NCI-H3122 GDSC2 5.3086 13.3301 -0.1387 15.4038
NCI-H1436 GDSC2 5.3299 7.0896 2.7348 0.6296
NCI-H1963 GDSC2 5.3365 7.0928 2.7364 0.6205
EKVX GDSC2 5.3418 11.9556 0.5504 11.9136
RERF-LC-Sq1 GDSC2 5.3812 15.1564 -0.9792 18.9022
NCI-H522 GDSC2 5.3929 13.4509 -0.1376 15.2094
NCI-H446 GDSC2 5.4063 8.224 2.3126 2.3115
ChaGo-K-1 GDSC2 5.4426 12.4104 0.4005 12.4681
NCI-H1770 GDSC2 5.4441 6.9665 2.8256 0.3178
LK-2 GDSC2 5.46 14.1714 -0.4407 16.443
NCI-H1299 GDSC2 5.4777 11.1561 1.0228 9.1159
UMC-11 GDSC2 5.4839 7.6457 2.5868 1.04
NCI-H524 GDSC2 5.5484 7.1404 2.8031 0.329
NCI-H810 GDSC2 5.5712 7.3001 2.7543 0.4403
NCI-H2722 GDSC2 5.6126 15.3953 -0.9285 18.1762
HOP-62 GDSC2 5.6373 8.2617 2.411 1.6114
COR-L105 GDSC2 5.6966 18.379 -2.3309 22.9948
NCI-H2405 GDSC2 5.7205 12.609 0.4931 11.4164
LC-1/sq GDSC2 5.74 10.3333 1.5675 5.6812
NCI-H250 GDSC2 5.77 7.8999 2.612 0.7488
COR-L32 GDSC2 5.8401 8.115 2.5598 0.8746
SW1573 GDSC2 5.8472 8.4551 2.4306 1.3402
Lu-99A GDSC2 5.891 8.5204 2.4245 1.327
COR-L311 GDSC2 5.9233 7.5951 2.7822 0.246
NCI-H1693 GDSC2 5.985 8.0149 2.656 0.5051
NCI-H510A GDSC2 6.0016 7.6816 2.7805 0.2272
IST-SL1 GDSC2 6.0026 8.5577 2.4593 1.1093
NCI-H2591 GDSC2 6.0338 16.4718 -1.153 18.1565
NCI-H1048 GDSC2 6.1132 7.9874 2.7147 0.3186
NCI-H520 GDSC2 6.1673 14.1416 0.0601 12.6449
HCC15 GDSC2 6.2043 15.4647 -0.5477 15.3192
LB647-SCLC GDSC2 6.228 7.773 2.8289 0.1122
NCI-H1876 GDSC2 6.2288 7.8057 2.8183 0.1243
NCI-H441 GDSC2 6.4517 16.3925 -0.8248 15.9842
⏷ Show the Full List of 166 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.7216 8.7148 1.6838 6.9032
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-10 GDSC2 2.9833 5.4401 1.9689 9.6025
OE33 GDSC2 3.6977 7.4869 1.5437 10.1697
KYSE-180 GDSC2 3.8618 13.6899 -1.4193 24.3914
KYSE-140 GDSC2 3.9266 8.545 1.1956 11.6663
TE-9 GDSC2 4.1483 6.7926 2.2176 4.9217
EC-GI-10 GDSC2 4.1606 12.6819 -0.6788 20.6654
TE-1 GDSC2 4.176 7.121 2.0785 5.7048
OE19 GDSC2 4.223 8.1702 1.6016 8.4931
TE-8 GDSC2 4.3345 10.6663 0.4557 14.7739
TE-6 GDSC2 4.3743 11.1125 0.2651 15.6663
COLO 680N GDSC2 4.7218 10.4184 0.8619 11.6239
TE-11 GDSC2 5.0074 13.6352 -0.5063 17.7796
KYSE-70 GDSC2 5.0289 10.2585 1.1524 9.318
TE-15 GDSC2 5.0316 12.8414 -0.0991 15.8554
TE-4 GDSC2 5.1762 9.5462 1.586 6.5725
KYSE-270 GDSC2 5.185 14.664 -0.8813 18.9572
KYSE-410 GDSC2 5.3983 18.559 -2.643 24.5878
OE21 GDSC2 5.4168 8.1853 2.3344 2.1948
TE-5 GDSC2 5.7393 14.3403 -0.3259 15.3157
KYSE-510 GDSC2 5.7873 13.8469 -0.0547 13.9631
KYSE-450 GDSC2 6.1695 15.4326 -0.556 15.4264
KYSE-520 GDSC2 6.7545 18.2457 -1.5093 18.0304
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC2 1.5218 4.1835 1.0696 20.5293
TOV-21G GDSC2 2.4449 9.1803 -0.3668 24.4896
IGROV-1 GDSC2 3.2458 8.0764 0.881 15.4334
TOV-112D GDSC2 3.269 6.35 1.7636 10.0095
JHOS-4 GDSC2 3.287 6.6687 1.6194 10.8572
OVISE GDSC2 3.6478 10.7012 -0.0998 19.4555
DOV13 GDSC2 3.8086 7.0202 1.8611 7.9157
JHOS-2 GDSC2 4.188 8.557 1.3865 9.8689
OVCAR-8 GDSC2 4.2971 9.3679 1.0681 11.4716
OVCAR-3 GDSC2 4.5625 6.6344 2.5496 2.2491
EFO-21 GDSC2 4.6643 13.6961 -0.7934 19.8503
OVCAR-5 GDSC2 4.7517 15.5968 -1.6685 22.9825
Caov-3 GDSC2 4.8373 10.4229 0.9413 10.9182
TYK-nu GDSC2 4.9607 9.9337 1.2619 8.8433
SK-OV-3 GDSC2 4.9862 12.7013 -0.0635 15.7924
OV-90 GDSC2 5.0097 11.9727 0.3097 13.8947
ES-2 GDSC2 5.272 8.8019 1.9859 4.1834
OV56 GDSC2 5.435 6.6433 2.9349 0.1171
Kuramochi GDSC2 5.4441 14.0679 -0.4016 16.3042
EFO-27 GDSC2 5.6155 15.4456 -0.951 18.2609
OAW42 GDSC2 5.7747 13.8969 -0.0874 14.1433
OVK18 GDSC2 5.8351 7.6238 2.7393 0.3645
OVCAR-4 GDSC2 6.1736 8.3159 2.6203 0.5116
OAW28 GDSC2 6.6191 10.0319 2.155 1.7593
OVTOKO GDSC2 7.2836 21.4026 -2.6675 20.8457
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 08.13 GDSC2 3.6813 9.2771 0.6383 15.5351
HuP-T3 GDSC2 3.9203 9.3782 0.7769 14.104
PaTu 8988t GDSC2 4.0903 9.4142 0.8901 13.0148
PL4 GDSC2 4.1708 7.0281 2.1197 5.466
SU.86.86 GDSC2 4.2136 9.0534 1.1611 11.1378
BxPC-3 GDSC2 4.229 9.2777 1.062 11.6754
PaTu 8902 GDSC2 4.3424 7.7044 1.9118 6.3497
Panc 10.05 GDSC2 4.5286 9.2349 1.3007 9.5699
Capan-2 GDSC2 4.5672 13.6615 -0.8503 20.3305
SUIT-2 GDSC2 4.5836 7.607 2.1174 4.6399
PSN1 GDSC2 4.631 7.6536 2.1256 4.5036
KP-4 GDSC2 4.6369 8.0695 1.9342 5.6066
HPAC GDSC2 4.6638 10.2766 0.8895 11.6054
QGP-1 GDSC2 4.7057 9.5124 1.2903 9.2315
DAN-G GDSC2 4.8002 12.4828 -0.0925 16.3764
YAPC GDSC2 4.8842 10.8532 0.7654 11.7808
KP-3 GDSC2 4.8928 11.4529 0.4796 13.2884
CFPAC-1 GDSC2 4.9784 9.7965 1.3393 8.3653
HuP-T4 GDSC2 5.0054 7.9199 2.2281 3.2948
MIA PaCa-2 GDSC2 5.1148 7.8876 2.3033 2.7387
KP-1N GDSC2 5.2063 10.3733 1.2159 8.5953
Capan-1 GDSC2 5.2126 6.8944 2.7597 0.6236
HPAF-II GDSC2 5.3072 9.6149 1.6358 6.0526
KP-2 GDSC2 5.4097 6.847 2.8552 0.2644
MZ-PC-1 GDSC2 6.0688 8.3764 2.5563 0.7437
AsPC-1 GDSC2 6.1559 14.6337 -0.1821 13.7943
Panc 02.03 GDSC2 7.0677 20.5436 -2.4023 20.4395
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 3.3203 5.5346 2.2142 7.0175
NCI-H2052 GDSC2 3.4707 10.3357 -0.0618 19.7874
MPP 89 GDSC2 4.3589 10.2877 0.661 13.6075
NCI-H28 GDSC2 4.9741 10.8328 0.8383 11.1805
IST-Mes1 GDSC2 5.3031 12.7361 0.1463 14.0458
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PC-3 GDSC2 3.9957 10.5372 0.2592 16.6924
VCaP GDSC2 4.0885 8.6563 1.2635 10.8475
LNCaP clone FGC GDSC2 4.6453 8.5373 1.7175 6.8633
NCI-H660 GDSC2 4.7032 6.3056 2.7635 1.0259
22Rv1 GDSC2 5.5923 7.9236 2.5258 1.1845
DU145 GDSC2 6.2413 8.1394 2.7086 0.2904
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 5.1102 7.1373 2.6183 1.2449
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-MEL-2 GDSC2 1.7382 5.2575 0.8473 20.891
VMRC-MELG GDSC2 2.0645 6.1307 0.7691 20.0659
SK-MEL-31 GDSC2 2.5422 3.7705 2.3171 9.067
IPC-298 GDSC2 2.6595 8.5195 0.1524 21.2749
A-431 GDSC2 2.9012 6.7455 1.248 14.333
RPMI-7951 GDSC2 3.1314 9.4162 0.1146 19.9412
CP50-MEL-B GDSC2 3.3105 5.3395 2.3036 6.4803
SK-MEL-28 GDSC2 3.3774 11.4505 -0.6962 22.9441
COLO 783 GDSC2 3.5306 6.8625 1.7224 9.5183
Hs 940.T GDSC2 3.5383 5.7354 2.2904 5.928
DJM-1 GDSC2 3.5497 5.6296 2.352 5.5095
UACC-62 GDSC2 3.5996 5.8919 2.2604 5.9555
G-mel GDSC2 3.6094 6.2187 2.1055 6.9032
SK-MEL-30 GDSC2 3.7509 5.3155 2.6561 3.12
MZ-MEL-7 GDSC2 3.7995 6.3696 2.1755 5.9813
SK-MEL-3 GDSC2 3.894 6.7522 2.057 6.4872
WM278 GDSC2 3.9029 8.598 1.151 11.9926
MMAc-SF GDSC2 3.9174 6.8877 2.0077 6.7364
HMV-II GDSC2 3.9294 9.8564 0.5462 15.3541
A101D GDSC2 4.0196 8.2689 1.4031 10.1875
WM115 GDSC2 4.0455 6.9014 2.0935 5.9058
IGR-37 GDSC2 4.2505 7.8687 1.7683 7.4209
CP66-MEL GDSC2 4.2893 5.8658 2.737 1.6625
A-388 GDSC2 4.3093 11.1795 0.1826 16.2535
G-361 GDSC2 4.325 11.2133 0.1778 16.2375
COLO 800 GDSC2 4.3896 10.1761 0.7388 13.103
M14 GDSC2 4.3949 7.0638 2.2517 4.2162
COLO 829 GDSC2 4.4561 9.6928 1.0251 11.332
LB2518-MEL GDSC2 4.4746 6.2571 2.6671 1.7613
COLO 792 GDSC2 4.4857 12.856 -0.5134 19.0978
A2058 GDSC2 4.6516 10.2797 0.8793 11.6905
451Lu GDSC2 4.6645 8.5178 1.7397 6.6932
IGR-1 GDSC2 4.7576 8.9891 1.577 7.4528
GAK GDSC2 4.7584 6.7328 2.6125 1.6606
LOX-IMVI GDSC2 4.7609 10.6516 0.7761 12.006
WM1552C GDSC2 4.8029 11.621 0.3325 14.2628
SK-MEL-2 GDSC2 4.842 6.3807 2.7976 0.7595
WT2-iPS GDSC2 4.8815 10.2787 1.0419 10.2571
Mel Ho GDSC2 4.9011 7.1881 2.4921 2.0711
WM35 GDSC2 4.9166 14.9946 -1.2446 21.0338
WM793 GDSC2 4.9597 6.6974 2.7254 0.9424
Mel JuSo GDSC2 5.0334 7.3815 2.4786 1.9693
SK-MEL-5 GDSC2 5.101 11.0181 0.8366 10.9108
HT-144 GDSC2 5.2161 12.1866 0.3518 13.2117
LB373-MEL-D GDSC2 5.2277 6.5684 2.8857 0.2638
A-375 GDSC2 5.261 12.3835 0.2877 13.4361
Hs 938.T GDSC2 5.3061 7.4995 2.5639 1.2861
CHL-1 GDSC2 5.4079 6.9819 2.8062 0.3806
RVH-421 GDSC2 5.4691 13.2466 0.0151 14.3159
COLO 679 GDSC2 5.4736 8.163 2.3723 1.9531
UACC-257 GDSC2 5.5631 6.948 2.8761 0.1781
SH-4 GDSC2 5.5662 7.5863 2.6455 0.7703
SK-MEL-24 GDSC2 6.7863 19.5145 -2.1005 20.0143
EquiPSC Line K2 GDSC2 4.6657 7.5175 2.2102 3.9556
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 3.9781 9.2699 0.8755 13.3918
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-402 GDSC2 3.2612 7.8403 1.0119 14.6236
SW982 GDSC2 3.6744 7.9512 1.2941 11.7535
TE 441.T GDSC2 3.741 7.0286 1.8052 8.4371
SK-UT-1 GDSC2 3.9321 7.1105 1.9089 7.3115
Rh41 GDSC2 3.9586 6.881 2.0411 6.4308
STS-0421 GDSC2 4.1337 7.8435 1.6968 8.1274
G-401 GDSC2 4.1715 14.1879 -1.4203 23.5655
MES-SA GDSC2 4.2596 12.0054 -0.2653 18.5583
HT-1080 GDSC2 4.3061 8.4576 1.5209 8.7825
VA-ES-BJ GDSC2 4.3192 7.4161 2.0345 5.6615
RKN GDSC2 4.5399 6.4468 2.6198 1.9135
Rh30 GDSC2 4.5526 8.3926 1.7244 7.0175
KYM-1 GDSC2 4.8977 10.685 0.8566 11.2514
GCT GDSC2 4.9624 12.5683 -0.0155 15.6183
SW684 GDSC2 5.0837 12.8416 -0.0614 15.5541
SW872 GDSC2 5.1946 10.6111 1.0951 9.2914
EW-8 GDSC2 5.4235 7.1117 2.7648 0.4847
RD GDSC2 6.287 13.2218 0.5709 9.9265
A-204 GDSC2 6.3383 10.6246 1.7723 3.7559
SK-LMS-1 GDSC2 8.6644 21.5045 -1.7961 15.643
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RF-48 GDSC2 2.5037 15.241 -3.3325 33.6565
RERF-GC-1B GDSC2 2.5449 15.5168 -3.4345 33.7543
SCH GDSC2 3.6309 9.2302 0.6212 15.7726
SNU-5 GDSC2 3.8894 7.988 1.4433 10.2774
NCI-N87 GDSC2 4.1142 9.779 0.7276 13.8664
SK-GT-2 GDSC2 4.1342 6.9513 2.1315 5.4747
MKN1 GDSC2 4.1823 9.8482 0.7451 13.5924
ECC12 GDSC2 4.2556 5.7751 2.7583 1.5994
Hs 746.T GDSC2 4.2944 7.8775 1.7949 7.1608
NUGC-3 GDSC2 4.3007 9.9311 0.7934 13.0226
KATO III GDSC2 4.3816 6.7225 2.4027 3.3643
23132/87 GDSC2 4.4501 14.284 -1.2496 22.2096
NUGC-4 GDSC2 4.4628 8.8384 1.447 8.8608
OCUM-1 GDSC2 4.4686 12.4623 -0.3314 18.3218
AGS GDSC2 4.4815 10.6408 0.5782 13.7513
ECC10 GDSC2 4.4919 8.8039 1.4842 8.5749
MKN7 GDSC2 4.5801 9.5596 1.1793 10.156
IM95 GDSC2 4.7033 9.8222 1.1386 10.1078
GCIY GDSC2 4.7199 8.5535 1.7594 6.4646
HGC-27 GDSC2 4.7516 9.8257 1.1707 9.8167
SNU-1 GDSC2 5.2877 7.328 2.624 1.0593
MKN45 GDSC2 5.709 14.8727 -0.6053 16.6129
TMK-1 GDSC2 6.0173 8.005 2.6722 0.4499
MKN28 GDSC2 6.2348 14.2946 0.0319 12.6444
SNG-M GDSC2 5.3259 12.1206 0.4599 12.4163
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC2 3.4496 6.6862 1.745 9.6036
K5 GDSC2 3.5321 8.1383 1.0866 13.3906
ML-1 [Human leukemia] GDSC2 3.9031 8.8981 1.0021 12.8633
8305C GDSC2 3.9048 11.3135 -0.1991 19.2054
FTC-133 GDSC2 4.0215 7.8771 1.5978 9.003
IHH-4 GDSC2 4.1429 7.8642 1.6933 8.1265
HTC-C3 GDSC2 4.2001 9.8677 0.749 13.5251
ASH-3 GDSC2 4.2415 9.7656 0.8307 12.9629
BHT-101 GDSC2 4.4064 12.2833 -0.2902 18.2916
B-CPAP GDSC2 4.4919 12.4974 -0.331 18.2602
WRO GDSC2 4.575 11.6592 0.146 15.7638
CAL-62 GDSC2 4.6215 6.6317 2.5835 1.9866
8505C GDSC2 4.9616 12.1467 0.1902 14.6091
TT2609-C02 GDSC2 5.5115 7.9082 2.4949 1.3797
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DOK GDSC2 1.9333 8.9601 -0.7242 27.8381
BB30-HNC GDSC2 2.2625 10.3802 -1.1248 28.2068
UPCI-SCC-090 GDSC2 2.3442 9.6633 -0.6964 26.2566
OSC-19 GDSC2 2.4287 5.7704 1.2919 15.67
BB49-HNC GDSC2 2.6003 9.1093 -0.1931 23.1623
KOSC-2 GDSC2 2.8274 9.0968 0.0127 21.4178
SAS GDSC2 3.0872 10.6485 -0.5387 23.1498
JHU-011 GDSC2 3.1571 8.0978 0.7953 16.1958
NCI-H3118 GDSC2 3.4589 9.476 0.3583 17.6908
HSC-2 GDSC2 3.5785 6.152 2.1146 6.9284
SCC-15 GDSC2 3.6841 5.8978 2.322 5.3527
BICR 22 GDSC2 3.735 7.8043 1.415 10.8568
HO-1-N-1 GDSC2 3.7988 6.3892 2.1653 6.0467
JHU-029 GDSC2 3.8272 11.1022 -0.1556 19.2149
HSC-3 GDSC2 3.85 6.5539 2.1221 6.1899
BICR 10 GDSC2 3.9571 11.7097 -0.3551 19.7859
SCC-9 GDSC2 4.0029 11.9579 -0.4425 20.0559
PCI-04B GDSC2 4.1823 7.1342 2.0764 5.7037
PCI-06A GDSC2 4.2146 9.5492 0.9173 12.5414
CAL-33 GDSC2 4.2445 8.1117 1.6456 8.1769
SAT [Human HNSCC] GDSC2 4.2447 9.1685 1.1275 11.2569
Ca9-22 GDSC2 4.2555 7.1459 2.1209 5.2769
Detroit 562 GDSC2 4.3738 13.1234 -0.7322 20.3321
SCC-4 GDSC2 4.4123 10.5516 0.5707 13.9635
PCI-15A GDSC2 4.4212 9.1501 1.2654 10.0256
CAL-27 GDSC2 4.4705 8.8093 1.4665 8.7276
FaDu GDSC2 4.487 11.1471 0.3328 15.0326
HSC-4 GDSC2 4.5239 6.1688 2.7314 1.3745
PE/CA-PJ15 GDSC2 4.5359 7.8042 1.9938 5.457
BICR 31 GDSC2 4.5491 6.6 2.5573 2.2282
KON GDSC2 4.5837 12.1255 -0.0777 16.8394
SKN-3 GDSC2 4.8398 10.5031 0.9042 11.1189
JHU-022 GDSC2 5.2842 16.064 -1.4968 21.1083
SCC-25 GDSC2 5.2942 7.2325 2.6645 0.8992
BHY GDSC2 5.3935 8.2338 2.3019 2.379
OSC-20 GDSC2 5.4014 14.1758 -0.4847 16.7701
LB771-HNC GDSC2 5.7684 16.2696 -1.2436 19.0762
BICR 78 GDSC2 6.3052 9.3053 2.3008 1.4597
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
639V GDSC2 3.7184 5.5634 2.512 4.0841
BFTC-905 GDSC2 3.7514 8.1936 1.2341 11.904
SW1710 GDSC2 3.8928 7.767 1.5554 9.5861
CAL-29 GDSC2 4.0489 9.1084 1.01 12.4346
KU-19-19 GDSC2 4.3018 11.1803 0.1765 16.3035
5637 GDSC2 4.3503 7.883 1.8311 6.8177
HT-1197 GDSC2 4.6749 11.6343 0.2323 15.0831
647V GDSC2 4.7078 9.73 1.1864 9.8244
TCCSUP GDSC2 5.1061 12.5633 0.0906 14.7664
T24 GDSC2 5.3818 7.8552 2.4548 1.6808
J82 GDSC2 5.5166 12.1658 0.5682 11.4505
RT-4 GDSC2 5.6387 23.1236 -4.7206 29.1076
RT-112 GDSC2 5.7369 13.9149 -0.122 14.3855
SW780 GDSC2 5.9303 20.8104 -3.3551 25.4074
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-39 GDSC2 1.624 7.2362 -0.183 26.6887
BPH-1 GDSC2 2.1957 10.0633 -1.0279 28.0779
PA-1 GDSC2 2.2595 4.1684 1.8573 12.9108
ACC-OV7 GDSC2 2.5456 5.7133 1.4305 14.4167
NEC8 GDSC2 3.0689 5.5205 2.0053 9.1005
SKN GDSC2 3.2096 7.6612 1.058 14.5077
DoTc2 4510 GDSC2 3.2134 6.0074 1.8877 9.3961
SW756 GDSC2 3.3301 10.4494 -0.235 21.0326
C-33 A GDSC2 3.6004 11.883 -0.7288 22.4293
OMC-1 [Human cervical carcinoma] GDSC2 3.6517 5.2065 2.6384 3.4584
MS751 GDSC2 3.8973 6.9156 1.9791 6.9618
JAR GDSC2 3.9245 7.738 1.5938 9.2704
OV17R GDSC2 3.9989 7.9573 1.5414 9.4024
SKG-IIIa GDSC2 4.0451 10.9105 0.1122 17.3062
PWR-1E GDSC2 4.0824 11.0385 0.0777 17.3783
HT-3 GDSC2 4.1222 6.6225 2.2815 4.5909
DSH1 GDSC2 4.159 9.3464 0.9757 12.3493
SW954 GDSC2 4.2302 8.5092 1.4408 9.442
JEG-3 GDSC2 4.4114 8.5803 1.5361 8.4491
LB831-BLC GDSC2 4.4708 11.4418 0.1752 15.8781
SiHa GDSC2 4.4715 10.0599 0.8563 12.2491
HEC-1 GDSC2 4.5594 8.0038 1.9146 5.8774
C-4-I GDSC2 4.569 9.0586 1.4147 8.8113
OVCA420 GDSC2 4.6373 7.8777 2.0248 5.0764
OVCA433 GDSC2 4.6533 11.5586 0.2536 15.0275
Ca Ski GDSC2 4.6676 10.6393 0.7151 12.5585
TC-YIK GDSC2 4.706 8.139 1.946 5.4028
UWB1.289 GDSC2 4.8584 9.4512 1.4238 8.1309
ME-180 GDSC2 4.8838 10.7608 0.8101 11.5379
HEY GDSC2 5.1062 11.3726 0.6691 11.8019
OVMIU GDSC2 5.239 14.2233 -0.6253 17.7547
SiSo GDSC2 5.3269 14.3584 -0.6277 17.5625
JHOS-3 GDSC2 5.3747 9.4047 1.7732 5.1747
PEO1 GDSC2 5.3798 11.808 0.6472 11.326
SW962 GDSC2 6.0336 7.802 2.7503 0.2733
HeLa GDSC2 6.3463 18.234 -1.7887 19.8413
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7889).
3 An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2015 Apr 9;125(15):2336-43.