Details of the Drug

General Information of Drug (ID: DMLASOF)

Drug Name
GSK2606414
Synonyms GSK PERK Inhibitor; 3-fluoro-GSK2606414; compound 38 [PMID: 22827572]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 451.4
Logarithm of the Partition Coefficient (xlogp) 3.8
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C24H20F3N5O
IUPAC Name
1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone
Canonical SMILES
CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F
InChI
InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)
InChIKey
SIXVRXARNAVBTC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
53469448
CAS Number
1337531-36-8
TTD ID
D0N4LR

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Myosin light chain kinase 2 (MYLK2) TTHLGB2 MYLK2_HUMAN Inhibitor [1]
PRKR-like endoplasmic reticulum kinase (PERK) TT5OU0D E2AK3_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.5624 5.7678 2.2931 5.8469
NOS-1 [Human HNSCC] GDSC2 2.1693 6.6951 0.5994 20.6249
TC-71 GDSC2 2.9317 5.8974 1.6961 11.476
SK-ES-1 GDSC2 3.479 6.3098 1.9568 8.1922
CHSA0011 GDSC2 3.4813 10.9644 -0.3673 21.194
EW-11 GDSC2 3.4837 9.3363 0.4485 17.1381
EW-12 GDSC2 3.4977 7.6091 1.323 12.0711
ES7 GDSC2 3.505 7.0998 1.5833 10.4544
EW-22 GDSC2 3.62 6.0299 2.2077 6.2336
EW-18 GDSC2 3.6405 6.5546 1.9628 7.7169
SK-PN-DW GDSC2 3.6427 6.4587 2.0122 7.4016
H-EMC-SS GDSC2 3.6618 6.8364 1.8393 8.4328
G-292 clone A141B1 GDSC2 3.7305 5.93 2.3408 5.1203
ES8 GDSC2 3.7449 7.1051 1.7702 8.6443
CAL-78 GDSC2 3.7576 6.8999 1.8818 7.9175
ES5 GDSC2 3.7677 6.7642 1.9567 7.4247
A-673 GDSC2 3.7701 6.1583 2.2577 5.5413
EW-13 GDSC2 3.8003 5.7033 2.5026 3.9509
HuO9 GDSC2 3.8094 10.0435 0.3582 16.6883
EW-24 GDSC2 3.8261 5.4741 2.6315 3.1045
CADO-ES1 GDSC2 3.8931 7.1948 1.8385 7.8434
NY GDSC2 3.9269 6.5824 2.1642 5.7451
SaOS-2 GDSC2 4.0026 6.0208 2.4889 3.5926
HOS GDSC2 4.0752 5.6659 2.7024 2.1978
EW-3 GDSC2 4.1892 11.6748 -0.1556 18.2288
U2OS GDSC2 4.2013 8.7495 1.3016 10.341
MG-63 GDSC2 4.214 12.4269 -0.5102 19.7903
EW-1 GDSC2 4.2791 7.4524 1.9897 6.0174
HuO-3N1 GDSC2 4.2865 14.6771 -1.5732 23.8145
EW-16 GDSC2 4.3611 6.9236 2.296 4.0221
MHH-ES-1 GDSC2 4.6129 7.8697 2.0129 5.1932
U-CH2 GDSC2 4.7355 8.2482 1.9137 5.5336
ES6 GDSC2 4.8016 9.1497 1.5298 7.6363
CHSA8926 GDSC2 4.9236 14.3745 -0.9329 19.7889
CAL-72 GDSC2 5.0797 7.6902 2.3703 2.4455
EW-7 GDSC2 5.1394 7.2095 2.6028 1.2823
CHSA0108 GDSC2 5.2378 12.1432 0.3879 12.9789
ES4 GDSC2 6.2733 8.6045 2.5542 0.6396
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 157 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 3.9602 6.864 2.0506 6.3685
EoL-1 GDSC2 -5.3683 -2.5614 -5.3711 83.1983
MOLM-13 GDSC2 -2.453 0.9857 -2.5292 57.2949
Kasumi-1 GDSC2 -0.6223 5.3929 -1.6835 42.5295
MOLM-16 GDSC2 0.2762 1.7723 0.2609 30.6411
SUP-B8 GDSC2 0.9347 3.4205 0.6891 25.2413
GDM-1 GDSC2 0.9959 6.371 -0.4048 30.3048
CML-T1 GDSC2 1.0473 6.9837 -0.6319 31.0101
ALL-PO GDSC2 1.1621 7.9123 -0.9522 31.7339
Ku812 GDSC2 1.496 3.7045 1.213 19.8402
JURL-MK1 GDSC2 1.5288 6.7805 -0.0607 26.4989
SR GDSC2 1.59 3.6277 1.3403 18.716
BC-1 GDSC2 1.8691 6.0634 0.6097 21.7018
JVM-2 GDSC2 1.883 5.2373 1.0034 19.4233
TALL-1 [Human adult T-ALL] GDSC2 1.8892 5.5382 0.8729 20.1472
MOLT-16 GDSC2 1.9439 4.9938 1.1742 18.1907
BE-13 GDSC2 2.021 23.6593 -7.9502 40.9471
KY821 GDSC2 2.0479 5.5523 1.0244 18.6621
LAMA-84 GDSC2 2.1623 4.6672 1.5419 15.1634
KE-37 GDSC2 2.172 4.1579 1.7698 13.7799
697 GDSC2 2.1994 6.0976 0.9153 18.7277
AMO1 GDSC2 2.2549 38.4734 -15.1507 44.1333
A3/Kawakami GDSC2 2.301 4.4725 1.7697 13.2638
P12-Ichikawa GDSC2 2.3494 6.0488 1.0823 17.2053
MEG-01 GDSC2 2.3672 4.0048 2.0379 11.4139
MHH-CALL-2 GDSC2 2.4219 15.6366 -3.6006 34.4421
L-1236 GDSC2 2.5404 8.6304 -0.0087 22.4816
NALM-6 GDSC2 2.8778 4.5207 2.3215 7.7555
DB GDSC2 2.8904 4.5324 2.3279 7.6715
DEL GDSC2 2.9012 22.425 -6.5824 37.7398
SUP-HD1 GDSC2 2.9493 4.9692 2.1703 8.4525
MY-M12 GDSC2 2.9597 6.2048 1.5685 12.1793
ST486 GDSC2 2.9685 5.291 2.0293 9.2717
EM-2 GDSC2 3.0345 6.615 1.4301 12.7978
KCL-22 GDSC2 3.0452 4.7207 2.3804 6.8181
L-428 GDSC2 3.1473 4.8247 2.4205 6.2364
OCI-AML-3 GDSC2 3.1478 8.446 0.6133 17.2489
SUP-T1 GDSC2 3.1576 4.8934 2.3954 6.3624
Daudi GDSC2 3.1806 4.3464 2.6876 4.4471
KG-1 GDSC2 3.1875 6.5248 1.6071 11.2311
RPMI-6666 GDSC2 3.1901 7.1228 1.3105 13.0499
NB4 GDSC2 3.2117 6.6202 1.5801 11.3258
OCI-AML-5 GDSC2 3.22 10.3314 -0.2681 21.5217
JVM-3 GDSC2 3.2216 13.5325 -1.8672 27.7185
Raji GDSC2 3.2227 5.8927 1.953 8.9565
HAL-01 GDSC2 3.2291 5.3233 2.2429 7.1063
OCI-Ly7 GDSC2 3.267 6.5874 1.6432 10.7684
HDLM-2 GDSC2 3.2706 4.906 2.4867 5.4391
Loucy GDSC2 3.2846 5.9314 1.986 8.5643
Karpas-422 GDSC2 3.3232 6.7549 1.6065 10.831
P30/OHK GDSC2 3.3239 12.2083 -1.1196 24.8051
SK-MM-2 GDSC2 3.3271 6.3627 1.8058 9.5741
ALL-SIL GDSC2 3.3314 4.8175 2.582 4.6572
MM1.S GDSC2 3.3686 6.9009 1.5712 10.9177
A4/Fukuda GDSC2 3.3853 5.0566 2.5068 4.9793
RS4;11 GDSC2 3.3998 5.7851 2.1546 7.1665
IM-9 GDSC2 3.4005 5.3894 2.3529 5.911
U266B1 GDSC2 3.41 4.9066 2.6017 4.3103
ML-2 GDSC2 3.4334 6.9782 1.5859 10.6405
SKM-1 GDSC2 3.4419 6.1446 2.0093 7.965
WSU-NHL GDSC2 3.4434 6.2823 1.9417 8.3868
GR-ST GDSC2 3.4477 8.9957 0.5891 16.4789
CCRF-CEM GDSC2 3.4498 5.3167 2.429 5.2926
Farage GDSC2 3.4508 7.5663 1.3061 12.3078
BALL-1 GDSC2 3.4584 6.8194 1.6856 9.9493
HC-1 GDSC2 3.4773 5.268 2.4752 4.9263
OCI-Ly19 GDSC2 3.4799 6.8184 1.7035 9.7772
P32/ISH GDSC2 3.4893 5.8908 2.1742 6.7935
CESS GDSC2 3.4901 5.9551 2.1427 6.9902
MN-60 GDSC2 3.4999 4.9447 2.6536 3.7414
KMS-12-BM GDSC2 3.5229 6.108 2.0926 7.2161
RPMI-8226 GDSC2 3.5433 5.4985 2.4122 5.1478
Karpas-299 GDSC2 3.5433 6.1139 2.1059 7.0774
DoHH2 GDSC2 3.5689 5.4557 2.4532 4.8225
BC-3 GDSC2 3.5842 5.8618 2.2634 5.9767
TK [Human B-cell lymphoma] GDSC2 3.5989 5.5362 2.4363 4.8521
Jiyoye GDSC2 3.6028 6.6127 1.9043 8.1839
HEL GDSC2 3.6075 5.8493 2.2876 5.7638
GA-10 GDSC2 3.6198 7.1489 1.6507 9.7194
SUP-M2 GDSC2 3.6207 10.2333 0.112 18.4904
QIMR-WIL GDSC2 3.623 6.8007 1.8267 8.6155
EB2 GDSC2 3.6283 14.5433 -2.0356 27.1033
K-562 GDSC2 3.6449 5.8047 2.3384 5.3491
SCC-3 GDSC2 3.6582 7.3971 1.5574 10.1922
Reh GDSC2 3.6683 5.3237 2.593 3.7004
JeKo-1 GDSC2 3.6694 6.9064 1.8104 8.593
RPMI-8866 GDSC2 3.6735 6.8611 1.8361 8.4216
CRO-AP2 GDSC2 3.6755 5.6372 2.4441 4.6105
MHH-PREB-1 GDSC2 3.6828 7.8815 1.3355 11.4801
L-540 GDSC2 3.6947 6.4084 2.0772 6.8584
Hs 445 GDSC2 3.6967 13.3229 -1.3698 24.6675
JSC-1 GDSC2 3.7494 5.7132 2.4611 4.326
BONNA-12 GDSC2 3.7568 17.4182 -3.3672 30.369
HL-60 GDSC2 3.7575 7.0203 1.822 8.2899
Karpas-45 GDSC2 3.7687 8.4703 1.1099 12.5943
MOLT-13 GDSC2 3.7705 5.5584 2.5519 3.7153
ARH-77 GDSC2 3.771 5.4276 2.6158 3.322
RL GDSC2 3.7716 5.5785 2.5429 3.7685
KM-H2 GDSC2 3.7721 6.893 1.8962 7.7904
PF-382 GDSC2 3.7725 5.8144 2.4284 4.4743
BL-41 GDSC2 3.7757 5.8456 2.4154 4.5474
NOMO-1 GDSC2 3.7778 5.7591 2.4592 4.271
Jurkat GDSC2 3.7835 5.9479 2.3709 4.8047
TUR GDSC2 3.797 6.5224 2.0983 6.4682
OCI-AML-2 GDSC2 3.8066 5.909 2.4067 4.5284
Namalwa GDSC2 3.8089 16.7932 -3.0123 29.3727
SU-DHL-16 GDSC2 3.819 9.0802 0.8458 13.9885
DND-41 GDSC2 3.8414 6.1113 2.3329 4.9033
Karpas-231 GDSC2 3.855 5.6303 2.5761 3.3789
KMS-11 GDSC2 3.8565 5.8502 2.4708 4.0185
RCH-ACV GDSC2 3.8708 6.0854 2.3666 4.6267
ME1 GDSC2 3.8759 5.8165 2.5008 3.7922
KOPN-8 GDSC2 3.8763 17.814 -3.4675 30.3045
JJN-3 GDSC2 3.8871 5.9639 2.4372 4.1563
U-698-M GDSC2 3.8874 7.0868 1.8874 7.5546
MLMA GDSC2 3.89 6.5915 2.133 6.026
MC116 GDSC2 3.8947 5.28 2.7692 2.1429
NCI-H929 GDSC2 3.8956 84.5635 -36.8218 46.2295
CTV-1 GDSC2 3.9035 5.728 2.5622 3.3589
OCI-M1 GDSC2 3.9107 6.7205 2.0849 6.2747
Ramos.2G6.4C10 GDSC2 3.9287 201.4332 -95.2285 48.4464
SIG-M5 GDSC2 3.9476 5.7213 2.595 3.0698
EJM GDSC2 3.9531 6.0424 2.445 3.9628
LP-1 GDSC2 3.9601 6.5963 2.1813 5.5623
SUP-B15 GDSC2 3.9647 16.0958 -2.5376 27.7019
THP-1 GDSC2 4.0086 7.2841 1.8799 7.305
LC4-1 GDSC2 4.0143 6.3091 2.3585 4.356
NK-92MI GDSC2 4.0707 6.6579 2.2292 5.0198
SU-DHL-10 GDSC2 4.0744 5.227 2.8993 1.1247
CTB-1 GDSC2 4.1033 7.4099 1.8869 7.0384
MHH-CALL-4 GDSC2 4.2451 8.584 1.415 9.5601
CA46 GDSC2 4.2702 8.1163 1.6617 8.0197
SU-DHL-6 GDSC2 4.2855 7.187 2.1215 5.2099
ROS-50 GDSC2 4.315 6.8511 2.3004 4.0852
DG-75 GDSC2 4.3694 11.8354 -0.0965 17.4741
Karpas-620 GDSC2 4.3723 6.329 2.5773 2.3956
SU-DHL-1 GDSC2 4.3782 15.8699 -2.095 25.3252
VAL GDSC2 4.4661 7.6424 2.0247 5.4152
HT GDSC2 4.4882 6.2469 2.679 1.6818
RC-K8 GDSC2 4.5321 8.5958 1.6127 7.7245
PL-21 GDSC2 4.5613 9.6348 1.1293 10.4869
MOLP-8 GDSC2 4.5702 6.5258 2.6018 1.9641
VL51 GDSC2 4.6447 6.9967 2.4347 2.7402
KMOE-2 GDSC2 4.6686 6.5579 2.6405 1.6366
SU-DHL-8 GDSC2 4.7262 6.4368 2.7207 1.1909
SU-DHL-5 GDSC2 4.89 5.9944 2.9625 0.218
H9 GDSC2 4.9691 12.1184 0.2095 14.4951
SU-DHL-4 GDSC2 5.012 7.381 2.4677 2.0492
WIL2 NS GDSC2 5.053 7.0728 2.6173 1.3063
OPM-2 GDSC2 5.1042 6.4763 2.8713 0.351
Granta-519 GDSC2 5.1234 7.0367 2.665 1.0397
ATN-1 GDSC2 5.2689 6.8173 2.8116 0.4328
NU-DUL-1 GDSC2 5.3573 7.0118 2.7752 0.4901
Karpas-1106P GDSC2 5.5441 7.3087 2.7404 0.4913
HH [Human lymphoma] GDSC2 5.7307 8.2406 2.4628 1.3131
MOLT-4 GDSC2 5.8912 7.4433 2.8231 0.1842
L-363 GDSC2 7.6153 19.0091 -1.2971 15.6388
⏷ Show the Full List of 157 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC2 3.4542 9.5579 0.3135 17.9404
OACM5.1 C GDSC2 3.5127 9.8925 0.1943 18.386
ESO-26 GDSC2 3.9441 7.0012 1.9715 6.8955
OACP4 C GDSC2 4.1577 7.1743 2.04 5.9796
KYSE-50 GDSC2 4.3063 7.3998 2.0336 5.6943
KYSE-220 GDSC2 4.4279 7.1924 2.2125 4.3826
KYAE-1 GDSC2 4.6461 7.1353 2.3731 3.0754
ESO-51 GDSC2 4.6467 6.9788 2.4439 2.6874
TE-12 GDSC2 4.8996 10.4832 0.9556 10.6993
SK-GT-4 GDSC2 4.9491 8.9579 1.7172 6.2574
HCE-4 GDSC2 5.2892 16.678 -1.7959 22.1541
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 3.5826 6.0698 2.1588 6.6395
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-5 GDSC2 3.4812 5.5301 2.3476 5.7211
NB(TU)1 GDSC2 3.5033 7.2372 1.5133 10.8914
SK-N-MC-IXC GDSC2 3.5211 6.0007 2.1447 6.8933
CHP-134 GDSC2 3.5581 5.3845 2.4803 4.6806
SK-N-DZ GDSC2 3.6055 7.3629 1.5326 10.4883
SJNB-14 GDSC2 3.6721 11.7636 -0.6108 21.7212
SJNB-13 GDSC2 3.6898 5.959 2.296 5.5012
TGW GDSC2 3.7144 5.7221 2.4312 4.5963
KP-N-YN GDSC2 3.8211 9.891 0.4435 16.2037
SK-N-BE(2)-M17 GDSC2 3.8824 6.5457 2.1499 5.9392
Kelly GDSC2 3.9567 6.2266 2.3585 4.4823
SJNB-7 GDSC2 4.0844 7.8038 1.6803 8.3463
SJNB-17 GDSC2 4.2277 7.0287 2.1583 5.1105
KP-N-YS GDSC2 4.2436 6.9462 2.2084 4.7764
NH-12 GDSC2 4.2563 6.259 2.5398 2.8039
GOTO GDSC2 4.4099 6.7133 2.4243 3.1899
SJNB-10 GDSC2 4.4167 8.4606 1.5979 8.0688
CHP-126 GDSC2 4.453 9.2405 1.2442 10.0749
IMR-5 GDSC2 4.4647 11.1948 0.2925 15.2964
CHP-212 GDSC2 4.5529 6.5159 2.5966 2.0157
SiMa GDSC2 4.5633 6.9827 2.3934 3.1
NB69 GDSC2 4.6216 12.0134 0.006 16.3394
MHH-NB-11 GDSC2 4.7518 6.7631 2.5962 1.7485
GI-ME-N GDSC2 4.7749 12.699 -0.2177 17.0298
KP-N-RT-BM-1 GDSC2 4.8206 7.2795 2.4084 2.6134
SJNB-6 GDSC2 5.0906 7.264 2.5568 1.5355
LA-N-6 GDSC2 5.5766 7.3191 2.7495 0.4505
SK-N-AS GDSC2 5.7764 7.3627 2.8096 0.2379
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 3.615 5.9601 2.2384 6.0537
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1954 GDSC2 2.8914 7.1588 1.0339 15.6459
MDA-MB-453 GDSC2 3.2755 7.4037 1.2422 13.2073
MDA-MB-468 GDSC2 3.3749 6.7786 1.6375 10.4878
MFM-223 GDSC2 3.4068 6.201 1.9525 8.4224
OCUB-M GDSC2 3.4544 11.4438 -0.6292 22.431
BT-474 GDSC2 3.5038 5.7391 2.2614 6.2038
HCC1806 GDSC2 3.5155 6.1979 2.0419 7.5563
HCC1419 GDSC2 3.5664 6.328 2.0174 7.5719
Hs 578T GDSC2 3.6158 5.9014 2.2682 5.8641
MRK-nu-1 GDSC2 3.652 5.1933 2.6451 3.416
HCC2218 GDSC2 3.7031 8.7612 0.913 13.9225
AU565 GDSC2 3.7105 6.2302 2.1776 6.1896
T-47D GDSC2 3.7128 5.8797 2.3523 5.0916
EFM-19 GDSC2 3.7239 8.9382 0.8414 14.2756
CAMA-1 GDSC2 3.9473 7.724 1.6178 9.0659
JIMT-1 GDSC2 3.991 6.0353 2.4742 3.7054
ZR-75-30 GDSC2 4.0482 11.9847 -0.4201 19.8323
DU4475 GDSC2 4.0569 6.3531 2.3664 4.2168
HDQ-P1 GDSC2 4.0638 7.4511 1.8382 7.4295
CAL-51 GDSC2 4.0739 6.3409 2.3838 4.0762
UACC-893 GDSC2 4.1574 8.0483 1.6137 8.5755
HCC1569 GDSC2 4.175 7.3171 1.9829 6.2885
MDA-MB-436 GDSC2 4.1889 7.2818 2.0097 6.094
HCC70 GDSC2 4.1945 9.0739 1.1368 11.327
CAL-120 GDSC2 4.247 7.2664 2.0572 5.679
MCF-7 GDSC2 4.2602 8.7131 1.3627 9.8354
Evsa-T GDSC2 4.3435 8.2787 1.6347 8.0138
HCC2157 GDSC2 4.4137 12.7443 -0.5132 19.2814
HCC1428 GDSC2 4.4877 7.2841 2.2076 4.2967
MDA-MB-361 GDSC2 4.5208 11.6824 0.0939 16.159
BT-20 GDSC2 4.5874 10.0276 0.9563 11.4105
HCC1500 GDSC2 4.5878 12.8541 -0.4347 18.488
MDA-MB-231 GDSC2 4.6226 6.5746 2.6089 1.8547
BT-549 GDSC2 4.6358 6.7012 2.5608 2.0836
COLO 824 GDSC2 4.6572 7.4123 2.2534 3.7257
HCC38 GDSC2 4.7217 8.2746 1.8924 5.6842
HCC1143 GDSC2 4.7611 7.883 2.1 4.4127
MDA-MB-157 GDSC2 4.8216 7.5223 2.3007 3.1895
CAL-85-1 GDSC2 4.8404 10.0569 1.1206 9.9047
YMB-1-E GDSC2 5.009 10.2578 1.1393 9.4336
HCC1937 GDSC2 5.0425 7.1197 2.593 1.4246
EFM-192A GDSC2 5.1725 7.4757 2.5093 1.6614
HCC1599 GDSC2 5.4693 9.5738 1.7524 5.1301
MDA-MB-415 GDSC2 5.5272 7.9691 2.4777 1.4364
HCC1187 GDSC2 5.751 7.4588 2.7663 0.3354
MDA-MB-330 GDSC2 6.0707 8.0788 2.6662 0.4422
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-247MG GDSC2 2.4321 5.5519 1.4 15.0055
D-423MG GDSC2 2.7823 7.5103 0.7626 17.5755
8-MG-BA GDSC2 3.3947 9.5502 0.2682 18.3531
H4 GDSC2 3.4748 13.2894 -1.5349 25.8819
AM-38 GDSC2 3.5866 5.4315 2.4788 4.6162
A-172 GDSC2 3.6616 6.2638 2.1236 6.6531
U-87MG ATCC GDSC2 3.698 6.2432 2.1616 6.3213
D-566MG GDSC2 3.7081 6.7514 1.9175 7.8232
SF268 GDSC2 3.7525 5.6571 2.4908 4.1344
D-263MG GDSC2 3.8007 6.0031 2.3564 4.854
ONS-76 GDSC2 3.8027 7.0529 1.8404 8.0595
SF295 GDSC2 3.8103 5.4283 2.6427 3.0706
DBTRG-05MG GDSC2 3.8124 5.6303 2.5466 3.6535
LN-18 GDSC2 3.8217 9.4395 0.669 14.9745
SK-MG-1 GDSC2 3.8978 7.5869 1.6483 9.0039
D-502MG GDSC2 3.9282 9.0153 0.9634 13.0205
LN-405 GDSC2 3.9333 6.7945 2.065 6.3434
Onda 10 GDSC2 3.9641 7.2281 1.8747 7.4446
LN-229 GDSC2 4.0699 6.8524 2.1345 5.5992
GB-1 GDSC2 4.0876 7.5751 1.7948 7.6391
KINGS-1 GDSC2 4.0948 10.3851 0.4119 15.6292
Becker GDSC2 4.1023 12.7446 -0.7559 21.1483
YKG-1 GDSC2 4.1771 5.951 2.6333 2.4115
DK-MG GDSC2 4.235 9.2763 1.0672 11.6311
D-392MG GDSC2 4.2502 7.8779 1.7636 7.4503
YH-13 GDSC2 4.2817 7.8943 1.7778 7.2922
CAS-1 GDSC2 4.3423 6.2341 2.6027 2.3045
GaMG GDSC2 4.3608 8.4707 1.5535 8.461
SNB-75 GDSC2 4.3885 6.7353 2.401 3.3616
D-542MG GDSC2 4.3947 7.9373 1.8355 6.6945
PFSK-1 GDSC2 4.4769 8.0198 1.8518 6.4208
M059J GDSC2 4.4773 7.324 2.1823 4.4643
U-118MG GDSC2 4.5445 7.6455 2.0743 4.9665
KNS-42 GDSC2 4.5606 6.8112 2.4695 2.6842
Onda 11 GDSC2 4.5653 7.1072 2.3377 3.409
KS-1 [Human Krukenberg tumour] GDSC2 4.5734 8.017 1.9175 5.8316
42-MG-BA GDSC2 4.6496 12.4446 -0.1857 17.1887
KNS-81-FD GDSC2 4.6784 6.7235 2.5742 1.9553
SF539 GDSC2 4.6856 8.8445 1.5978 7.4825
GI-1 GDSC2 4.7009 6.9186 2.5012 2.3009
T98G GDSC2 4.7419 6.7957 2.577 1.8567
D-336MG GDSC2 4.7423 7.3024 2.3537 3.0266
KALS-1 GDSC2 4.8025 9.6875 1.2726 9.1208
U-251MG GDSC2 4.8525 8.2303 1.9957 4.8422
NMC-G1 GDSC2 4.8882 6.5387 2.756 0.8831
D283 Med GDSC2 4.9444 6.3388 2.8579 0.4758
Daoy GDSC2 5.0895 12.0565 0.3257 13.6299
D-245MG GDSC2 5.1114 9.8068 1.422 7.6254
SW1088 GDSC2 5.2071 7.1145 2.6721 0.9403
Hs 683 GDSC2 5.3972 6.5597 2.95 0.1041
SF126 GDSC2 5.4747 7.0672 2.8012 0.3638
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 4.1726 9.2433 1.0368 11.9628
ETK-1 GDSC2 4.2649 8.0465 1.6919 7.8498
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC2 3.0419 8.2624 0.6146 17.5717
RL95-2 GDSC2 3.2325 6.5715 1.6221 11.0023
ESS-1 GDSC2 3.424 4.8782 2.6272 4.1109
EN GDSC2 3.4878 4.8438 2.6944 3.5166
MFE-319 GDSC2 3.6024 4.9581 2.7242 3.0428
MFE-296 GDSC2 4.351 6.9076 2.297 4.0356
MFE-280 GDSC2 4.4601 8.0947 1.8045 6.7386
KLE GDSC2 4.6985 7.8839 2.0607 4.7527
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 GDSC2 2.1392 9.3226 -0.7133 27.0465
ACHN GDSC2 3.4318 8.5074 0.8202 15.2293
SW13 GDSC2 3.5528 6.7089 1.8168 8.8674
LB996-RCC GDSC2 3.5533 10.929 -0.2906 20.6306
786-O GDSC2 3.5746 5.6301 2.371 5.3247
KTCTL-26A GDSC2 3.6039 6.1326 2.1441 6.675
BFTC-909 GDSC2 3.6567 13.6145 -1.5481 25.415
A-498 GDSC2 3.9941 10.5431 0.2551 16.7182
KTCTL-13 GDSC2 4.0543 7.2287 1.9402 6.8266
RCC10RGB GDSC2 4.1163 6.0134 2.5666 2.9059
769-P GDSC2 4.1597 10.4747 0.4175 15.4282
KTCTL-140 GDSC2 4.186 7.7896 1.7609 7.6145
NCC010 GDSC2 4.2937 7.4479 2.0018 5.9126
LB2241-RCC GDSC2 4.3069 6.7231 2.3554 3.7776
LB1047-RCC GDSC2 4.3081 7.5367 1.969 6.0796
SN12C GDSC2 4.3135 8.7843 1.3666 9.685
KTCTL-195 GDSC2 4.3195 9.4613 1.0388 11.5854
SW156 GDSC2 4.3653 7.1152 2.2084 4.5295
A-704 GDSC2 4.3674 7.1402 2.1979 4.5872
VMRC-RCZ GDSC2 4.3912 6.4782 2.5208 2.6778
BB65-RCC GDSC2 4.4162 7.958 1.8403 6.6194
HA7-RCC GDSC2 4.4305 7.9028 1.8766 6.3716
Caki-1 GDSC2 4.4492 10.0207 0.8593 12.2865
KMRC-20 GDSC2 4.6621 11.956 0.0645 15.9525
OS-RC-2 GDSC2 4.9152 6.8729 2.6328 1.3829
TK-10 GDSC2 5.0342 8.3197 2.0647 4.1393
KTCTL-21 GDSC2 5.0832 7.8234 2.3141 2.7274
KTCTL-1M GDSC2 5.1018 7.3664 2.5197 1.693
VMRC-RCW GDSC2 5.1848 6.8578 2.7619 0.6345
UO-31 GDSC2 5.9835 7.9746 2.6701 0.4697
NCC021 GDSC2 6.1048 8.0091 2.7039 0.3437
RXF 393L GDSC2 6.4317 9.5845 2.2475 1.5592
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KM12 GDSC2 0.8389 3.9638 0.4131 27.1393
NCI-H716 GDSC2 2.0765 5.5378 1.0595 18.3483
HCT 15 GDSC2 3.0644 6.4348 1.546 11.9889
HT-55 GDSC2 3.2526 6.7598 1.5449 11.4219
DiFi GDSC2 3.2553 6.547 1.6535 10.7386
LoVo GDSC2 3.2792 7.5997 1.1474 13.7662
RKO GDSC2 3.4559 5.5548 2.3151 5.9951
LS411N GDSC2 3.6767 5.4369 2.5436 3.9876
SW626 GDSC2 3.6964 7.542 1.5152 10.3482
SNU-1040 GDSC2 3.7084 6.2922 2.1453 6.397
NCI-H508 GDSC2 3.7189 12.1762 -0.7789 22.3012
COLO205 GDSC2 3.7365 7.7859 1.4253 10.7897
MDST8 GDSC2 3.7453 5.2895 2.6647 3.0797
HT115 GDSC2 3.758 8.0325 1.3195 11.3731
C2BBe1 GDSC2 3.7685 8.0329 1.3275 11.2968
RCM-1 [Human ESC] GDSC2 3.8118 6.0888 2.3225 5.0374
HCT 116 GDSC2 3.8789 5.7661 2.5271 3.6254
SW948 GDSC2 3.8791 5.4804 2.6642 2.7958
COLO 320HSR GDSC2 3.9216 6.0927 2.3989 4.3135
CaR-1 GDSC2 4.0053 7.0468 1.9937 6.6124
SW1417 GDSC2 4.0063 11.2487 -0.0866 18.3895
CL-11 GDSC2 4.0254 12.7988 -0.8438 21.7214
LS123 GDSC2 4.0489 8.1695 1.4741 9.6857
HT-29 GDSC2 4.0694 6.8382 2.141 5.5607
LS513 GDSC2 4.1476 7.7746 1.7406 7.828
SW837 GDSC2 4.1567 6.556 2.3365 4.1885
SW620 GDSC2 4.2191 7.0732 2.1311 5.2928
GP5d GDSC2 4.3078 7.4317 2.0193 5.7773
SNU-407 GDSC2 4.3537 8.4701 1.5488 8.5055
CW-2 GDSC2 4.3581 7.9136 1.8218 6.8568
SK-CO-1 GDSC2 4.3635 6.1311 2.661 1.9548
HCC2998 GDSC2 4.3987 7.6165 1.9922 5.7473
SW1463 GDSC2 4.4041 6.6022 2.4719 2.9305
SNU-175 GDSC2 4.4093 6.7892 2.3889 3.3932
SNU-283 GDSC2 4.5156 8.6277 1.5859 7.9194
T84 GDSC2 4.5206 7.8862 1.9449 5.7771
SNU-81 GDSC2 4.5307 7.1653 2.2899 3.7419
CCK-81 GDSC2 4.6138 15.6611 -1.8069 23.7965
SNU-C1 GDSC2 4.6173 6.9165 2.4549 2.6738
SW1116 GDSC2 4.735 11.9268 0.1329 15.4358
SNU-61 GDSC2 4.8419 12.1617 0.0959 15.3608
SW48 GDSC2 5.0056 7.0396 2.6081 1.3967
SNU-C5 GDSC2 5.0898 10.4792 1.0878 9.5506
COLO 678 GDSC2 5.1764 8.1349 2.2287 3.0372
LS1034 GDSC2 5.2792 6.5111 2.9248 0.1689
LS180 GDSC2 5.3369 6.9944 2.7734 0.5064
SNU-C2B GDSC2 5.483 11.8375 0.7026 10.8182
NCI-H747 GDSC2 5.5227 7.828 2.5322 1.2189
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 5.5303 7.1715 2.785 0.38
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 2.5126 5.1383 1.6748 13.0423
JHH-6 GDSC2 3.1526 8.0257 0.8275 16.0254
JHH-4 GDSC2 3.2655 8.6394 0.616 16.8737
JHH-2 GDSC2 3.394 4.829 2.6276 4.1913
HLE GDSC2 3.6727 7.8142 1.361 11.3532
Huh-7 GDSC2 4.0215 7.7509 1.66 8.6236
HuH-1 GDSC2 4.0822 8.3912 1.3896 10.1111
SNU-449 GDSC2 4.1318 6.575 2.3108 4.3942
JHH-1 GDSC2 4.167 6.8624 2.1969 5.0068
SNU-398 GDSC2 4.4596 8.1572 1.7742 6.9209
Hep-G2/C3A GDSC2 4.6669 7.4063 2.262 3.6605
SK-HEP-1 GDSC2 4.7198 8.6889 1.6949 6.8421
JHH-7 GDSC2 5.2258 12.638 0.1394 14.2532
SNU-387 GDSC2 5.327 15.3125 -1.0955 19.4895
SNU-423 GDSC2 5.4843 8.5683 2.2062 2.7317
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 166 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H322M GDSC2 1.6288 6.7442 0.0544 25.5418
NCI-H2795 GDSC2 1.9146 6.0858 0.6439 21.3375
A-427 GDSC2 2.3322 5.468 1.3432 15.7106
CAL-12T GDSC2 2.6079 8.6066 0.0633 21.8965
HCC78 GDSC2 2.9687 7.5343 0.9146 16.0975
A-549 GDSC2 2.9939 6.9495 1.228 14.1578
NCI-H2122 GDSC2 3.0237 5.73 1.8612 10.1491
NCI-H1581 GDSC2 3.2537 4.5099 2.6702 4.3291
RERF-LC-MS GDSC2 3.2772 4.7234 2.5836 4.8063
BEN GDSC2 3.3164 6.0691 1.9437 8.7375
NCI-H460 GDSC2 3.4412 4.5715 2.7935 3.0146
NCI-H82 GDSC2 3.4466 6.2661 1.9524 8.3101
NCI-H526 GDSC2 3.4958 8.496 0.8783 14.7099
UMC-11 GDSC2 3.5307 6.9524 1.6776 9.7968
NCI-H1048 GDSC2 3.5503 6.1371 2.0998 7.0969
NCI-H2731 GDSC2 3.5962 5.8557 2.2757 5.8678
NCI-H1975 GDSC2 3.6043 9.722 0.354 17.2907
SK-MES-1 GDSC2 3.6103 6.6258 1.9038 8.1671
SBC-5 GDSC2 3.6222 5.3758 2.5332 4.1857
LXF 289 GDSC2 3.6236 8.5319 0.9639 13.8505
NCI-H1155 GDSC2 3.6278 5.3402 2.555 4.0357
DMS 114 GDSC2 3.6468 5.5497 2.4659 4.5456
NCI-H1694 GDSC2 3.6542 6.4433 2.0287 7.2677
Calu-6 GDSC2 3.6556 6.3831 2.0597 7.0695
COR-L23 GDSC2 3.6651 7.364 1.5793 10.0383
HCC44 GDSC2 3.6776 6.044 2.2447 5.8528
Lu-99A GDSC2 3.7049 6.511 2.0342 7.1018
SHP-77 GDSC2 3.7063 6.4322 2.0744 6.8465
NCI-H841 GDSC2 3.709 6.0854 2.248 5.753
DMS 53 GDSC2 3.7234 8.3395 1.1394 12.5438
NCI-H2141 GDSC2 3.7262 5.7867 2.4081 4.7115
NCI-H720 GDSC2 3.7288 5.7227 2.4415 4.4971
NCI-H1792 GDSC2 3.7495 5.7946 2.4213 4.5731
NCI-H2081 GDSC2 3.7644 8.0753 1.3032 11.4541
NCI-H1770 GDSC2 3.7758 6.0333 2.3234 5.1187
NCI-H2228 GDSC2 3.7818 7.7984 1.4545 10.4914
RERF-LC-Sq1 GDSC2 3.787 9.1063 0.8076 14.2933
KNS-62 GDSC2 3.8108 5.7922 2.4667 4.1482
EMC-BAC-2 GDSC2 3.8237 6.9859 1.8894 7.7014
Ms-1 GDSC2 3.8354 5.9044 2.4295 4.3206
NCI-H1568 GDSC2 3.8553 11.1387 -0.1514 19.1162
NCI-H1876 GDSC2 3.8568 6.1509 2.3246 4.9185
NCI-H1944 GDSC2 3.8613 7.9983 1.4166 10.5124
NCI-H810 GDSC2 3.8888 5.715 2.5585 3.4129
Calu-3 GDSC2 3.8899 8.8497 1.016 12.818
NCI-H524 GDSC2 3.9096 6.0669 2.403 4.3156
HCC827 GDSC2 3.9221 7.8598 1.5316 9.6563
LOU-NH91 GDSC2 3.9398 6.9979 1.97 6.9156
NCI-H2030 GDSC2 3.9415 7.0003 1.9701 6.9109
NCI-H211 GDSC2 3.9614 6.5593 2.2002 5.4432
NCI-H2373 GDSC2 3.9679 6.5012 2.2332 5.2253
NCI-H1299 GDSC2 3.9754 6.5881 2.1962 5.4357
Lu-65 GDSC2 3.9777 7.1283 1.9338 7.0474
NCI-H2170 GDSC2 3.9863 6.3942 2.2981 4.7861
Lu-165 GDSC2 3.9867 10.2963 0.3721 16.1289
NCI-H3255 GDSC2 4.0026 7.369 1.8338 7.6036
NCI-H522 GDSC2 4.004 8.6489 1.2033 11.42
NCI-H358 GDSC2 4.0211 7.4444 1.8104 7.7024
COR-L311 GDSC2 4.0411 6.3676 2.3488 4.357
PC-14 GDSC2 4.0444 7.9566 1.5757 9.081
NCI-H250 GDSC2 4.0451 7.3923 1.8534 7.3807
IST-SL2 GDSC2 4.0458 9.2733 0.9259 12.926
Lu-139 GDSC2 4.0475 6.78 2.1539 5.531
NCI-H2023 GDSC2 4.0483 6.3524 2.361 4.2681
NCI-H596 GDSC2 4.0544 7.3259 1.8927 7.1177
LCLC-103H GDSC2 4.0595 7.1671 1.974 6.6067
NCI-H23 GDSC2 4.0633 9.258 0.9469 12.7605
NCI-H1623 GDSC2 4.0746 6.7242 2.1999 5.1893
NCI-H1437 GDSC2 4.0807 6.1758 2.467 3.5632
SW1271 GDSC2 4.0834 6.3757 2.3735 4.1183
NCI-H1781 GDSC2 4.0874 11.7521 -0.2734 19.0546
CPC-N GDSC2 4.0963 6.0598 2.532 3.1468
NCI-H2591 GDSC2 4.106 8.1028 1.5493 9.09
NCI-H226 GDSC2 4.1646 8.2056 1.5418 8.9932
NCI-H647 GDSC2 4.1834 8.2601 1.5288 9.0261
SBC-3 GDSC2 4.1853 7.5276 1.888 6.8428
NCI-H748 GDSC2 4.2072 7.5151 1.9094 6.6629
NCI-H2461 GDSC2 4.208 7.359 1.9856 6.1979
DMS 273 GDSC2 4.2179 10.022 0.6861 13.8275
NCI-H209 GDSC2 4.2262 43.1342 -15.8357 41.8171
NCI-H2818 GDSC2 4.232 6.5891 2.3703 3.8357
HARA [Human squamous cell lung carcinoma] GDSC2 4.2354 7.3048 2.0308 5.8636
IST-SL1 GDSC2 4.2556 15.1181 -1.8173 24.7328
NCI-H446 GDSC2 4.2666 7.2758 2.0661 5.5834
NCI-H727 GDSC2 4.2696 7.8682 1.782 7.2947
SK-LU-1 GDSC2 4.2831 7.5033 1.9679 6.1398
RERF-LC-KJ GDSC2 4.2905 10.7046 0.4034 15.1627
NCI-H290 GDSC2 4.3296 7.0289 2.2259 4.4965
NCI-H510A GDSC2 4.3488 6.599 2.4396 3.2116
HCC366 GDSC2 4.36 8.8801 1.3533 9.653
IA-LM GDSC2 4.3638 6.7709 2.369 3.5911
NCI-H1651 GDSC2 4.3656 8.3845 1.5989 8.1786
NCI-H146 GDSC2 4.3836 7.2065 2.1772 4.6774
NCI-H1693 GDSC2 4.3999 6.4596 2.5344 2.5878
NCI-H2803 GDSC2 4.403 7.3152 2.1384 4.8682
NCI-H2171 GDSC2 4.4154 8.6795 1.4907 8.7103
NCI-H2291 GDSC2 4.4349 7.0072 2.3036 3.8382
NCI-H1105 GDSC2 4.4464 9.6942 1.0174 11.3998
NCI-H2029 GDSC2 4.4486 6.2818 2.642 1.9293
ABC-1 GDSC2 4.4542 8.5277 1.5916 8.022
NCI-H2810 GDSC2 4.4621 7.5637 2.0594 5.2176
NCI-H292 GDSC2 4.4761 8.4877 1.6262 7.7675
LK-2 GDSC2 4.4891 9.9679 0.9144 11.8805
VMRC-LCD GDSC2 4.5082 6.5295 2.5656 2.2454
NCI-H2369 GDSC2 4.5093 7.7924 1.9819 5.5809
EKVX GDSC2 4.5178 7.6557 2.0523 5.1485
NCI-H2227 GDSC2 4.5214 7.9485 1.9157 5.9486
NCI-H2135 GDSC2 4.5371 6.6645 2.5218 2.4365
NCI-H2869 GDSC2 4.5389 7.2007 2.2785 3.7922
LC-2/ad GDSC2 4.5448 8.1901 1.8161 6.4908
NCI-H196 GDSC2 4.6118 6.8655 2.4747 2.5753
LC-1/sq GDSC2 4.6398 7.5101 2.1977 4.0732
HOP-62 GDSC2 4.6527 6.8688 2.4963 2.3975
NCI-H1836 GDSC2 4.6654 7.3809 2.2727 3.6025
COR-L32 GDSC2 4.6702 12.3261 -0.1118 16.7874
NCI-H2722 GDSC2 4.6769 10.186 0.9431 11.2751
NCI-H1755 GDSC2 4.6914 11.2821 0.4175 14.0902
HOP-92 GDSC2 4.7107 18.4398 -3.1131 27.4391
LCLC-97TM1 GDSC2 4.7232 7.4643 2.2692 3.524
COR-L303 GDSC2 4.7304 6.4877 2.7016 1.2728
NCI-H1092 GDSC2 4.7709 6.6467 2.6554 1.441
EBC-1 GDSC2 4.7846 8.5675 1.795 6.1278
EPLC-272H GDSC2 4.7873 10.2358 0.997 10.7201
NCI-H2444 GDSC2 4.7902 5.7644 3.0066 0.1594
NCI-H3122 GDSC2 4.7948 10.3815 0.9315 11.0693
NCI-H740 GDSC2 4.8013 7.5673 2.2686 3.3978
NCI-H1915 GDSC2 4.8148 8.2753 1.9513 5.1657
NCI-H1563 GDSC2 4.8297 7.0168 2.5281 1.9851
NCI-H2804 GDSC2 4.8327 8.0867 2.0499 4.5695
DMS 79 GDSC2 4.8353 7.3341 2.3925 2.6761
NCI-H1793 GDSC2 4.8399 7.886 2.1466 4.0115
NCI-H2196 GDSC2 4.8405 6.5582 2.726 1.0507
NCI-H1963 GDSC2 4.8667 6.8461 2.6199 1.4963
NCI-H1734 GDSC2 4.8855 7.253 2.4557 2.2758
Lu-134-A GDSC2 4.8887 13.2567 -0.4078 17.6252
NCI-H2087 GDSC2 4.8925 7.9463 2.1505 3.9007
COR-L321 GDSC2 4.8931 6.8428 2.6344 1.3997
NCI-H661 GDSC2 4.8987 7.1836 2.4928 2.0707
NCI-H345 GDSC2 4.9041 6.0593 2.9447 0.254
Lu-135 GDSC2 4.942 6.4819 2.8022 0.6646
NCI-H2110 GDSC2 4.9471 17.0244 -2.2266 24.3594
NCI-H2085 GDSC2 4.9761 8.6852 1.8615 5.3815
NCI-H520 GDSC2 4.9843 7.2536 2.5076 1.8892
SW1573 GDSC2 4.9883 8.3423 2.027 4.4259
NCI-H650 GDSC2 5.0011 11.795 0.3901 13.5026
COR-L105 GDSC2 5.0361 14.3029 -0.8137 19.029
NCI-H2595 GDSC2 5.0978 7.1098 2.6236 1.2347
NCI-H1355 GDSC2 5.1083 17.3962 -2.2876 24.1745
SBC-1 GDSC2 5.2403 6.8792 2.777 0.5509
LB647-SCLC GDSC2 5.2501 7.2381 2.6426 1.0184
NCI-H1993 GDSC2 5.2788 7.1833 2.6769 0.8654
NCI-H1650 GDSC2 5.3071 7.9344 2.3845 2.0878
NCI-H1869 GDSC2 5.3072 7.1349 2.708 0.7341
NCI-H2172 GDSC2 5.3996 7.3156 2.6781 0.7727
NCI-H513 GDSC2 5.4577 10.4203 1.3556 7.3314
HCC33 GDSC2 5.4963 7.163 2.7749 0.4212
NCI-H1435 GDSC2 5.5596 7.3547 2.7296 0.5135
ChaGo-K-1 GDSC2 5.6087 8.2415 2.4057 1.6624
NCI-H838 GDSC2 5.6934 7.0564 2.8852 0.1346
NCI-H1436 GDSC2 5.6977 7.2754 2.8112 0.2588
COLO 668 GDSC2 5.7044 7.5367 2.7203 0.4674
NCI-H441 GDSC2 5.7892 12.2945 0.6876 10.2795
NCI-H1666 GDSC2 5.8027 8.5645 2.3663 1.6404
NCI-H2405 GDSC2 5.8223 8.293 2.4833 1.1592
EMC-BAC-1 GDSC2 5.915 9.216 2.1525 2.4661
HCC15 GDSC2 6.713 21.3859 -3.0636 23.0671
⏷ Show the Full List of 166 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 5.3458 7.482 2.5892 1.1466
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC2 3.3426 7.1853 1.4074 12.0036
TE-11 GDSC2 3.4871 5.9025 2.1666 6.8475
TE-6 GDSC2 3.5768 9.4701 0.4575 16.819
OE33 GDSC2 3.933 6.0969 2.4048 4.2525
TE-8 GDSC2 4.0094 8.2929 1.3836 10.3305
TE-5 GDSC2 4.0846 7.2326 1.96 6.6343
KYSE-140 GDSC2 4.1087 9.2866 0.9673 12.5262
EC-GI-10 GDSC2 4.111 9.0393 1.0912 11.8037
COLO 680N GDSC2 4.1905 6.9897 2.1517 5.2299
TE-9 GDSC2 4.1928 7.2088 2.0477 5.855
KYSE-520 GDSC2 4.236 6.9495 2.2018 4.8317
TE-1 GDSC2 4.2415 6.7723 2.2898 4.2941
KYSE-180 GDSC2 4.3472 9.9628 0.8124 12.7999
TE-4 GDSC2 4.6904 7.0194 2.4506 2.584
KYSE-270 GDSC2 5.0698 7.1431 2.5966 1.3798
KYSE-70 GDSC2 5.1181 11.8584 0.4422 12.9675
TE-10 GDSC2 5.2281 7.1944 2.65 1.0083
OE19 GDSC2 5.2728 7.1785 2.6762 0.8727
KYSE-510 GDSC2 5.6609 13.3778 0.0845 13.5676
OE21 GDSC2 6.0346 13.4688 0.292 11.7903
KYSE-410 GDSC2 7.2443 20.2513 -2.1389 19.2655
KYSE-450 GDSC2 8.89 20.0056 -0.963 12.2763
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC2 2.5099 5.7145 1.3962 14.7512
IGROV-1 GDSC2 2.6915 7.0829 0.8933 17.1268
TOV-21G GDSC2 3.2744 6.3843 1.751 10.0726
TOV-112D GDSC2 3.4489 5.3598 2.4067 5.4359
EFO-27 GDSC2 3.7817 6.5251 2.0855 6.5858
OV-90 GDSC2 3.892 6.0054 2.4205 4.2477
OAW42 GDSC2 3.9686 7.4114 1.7879 7.9687
TYK-nu GDSC2 4.0249 9.4543 0.82 13.5826
OVCAR-8 GDSC2 4.0359 7.0967 1.9914 6.5548
OVTOKO GDSC2 4.0419 10.6852 0.2218 16.7598
JHOS-2 GDSC2 4.0883 7.1489 2.0034 6.36
JHOS-4 GDSC2 4.3515 18.8143 -3.5839 29.4317
EFO-21 GDSC2 4.3719 6.5133 2.4932 2.8657
OVCAR-4 GDSC2 4.4509 9.1261 1.2985 9.7624
OVK18 GDSC2 4.5323 9.1505 1.3444 9.3059
OV56 GDSC2 4.6089 5.7367 2.9456 0.4036
OVCAR-3 GDSC2 4.6176 7.9785 1.9647 5.4659
SK-OV-3 GDSC2 4.7093 12.3239 -0.0817 16.5468
DOV13 GDSC2 4.8275 7.5691 2.2831 3.276
ES-2 GDSC2 4.862 10.1248 1.1027 9.958
OVISE GDSC2 5.044 9.7748 1.3931 7.9244
Caov-3 GDSC2 5.2907 6.7084 2.8596 0.2992
Kuramochi GDSC2 5.3813 12.3609 0.3823 12.693
OVCAR-5 GDSC2 6.0626 7.9985 2.6918 0.3856
OAW28 GDSC2 6.1718 8.9647 2.3751 1.2873
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAC GDSC2 3.0759 6.9874 1.2803 13.5841
Panc 02.03 GDSC2 3.2398 7.5249 1.1516 13.8586
CFPAC-1 GDSC2 3.3297 6.9671 1.5058 11.4356
DAN-G GDSC2 3.4076 7.1169 1.4953 11.2744
SU.86.86 GDSC2 3.6234 5.1807 2.6303 3.5767
BxPC-3 GDSC2 3.6258 8.5712 0.946 13.9479
YAPC GDSC2 3.67 7.5824 1.4743 10.6702
SUIT-2 GDSC2 3.694 5.9297 2.3136 5.3801
PaTu 8902 GDSC2 3.7704 5.5658 2.5483 3.7382
PSN1 GDSC2 3.7914 5.5654 2.5633 3.5981
KP-3 GDSC2 3.8242 7.2588 1.7548 8.5353
Capan-2 GDSC2 4.0661 6.3763 2.3616 4.2266
Capan-1 GDSC2 4.1467 6.7326 2.2453 4.7574
MIA PaCa-2 GDSC2 4.187 6.8424 2.2199 4.8253
PaTu 8988t GDSC2 4.2412 8.7441 1.3336 10.0543
HuP-T4 GDSC2 4.2516 7.0501 2.1641 5.0252
HuP-T3 GDSC2 4.2913 8.1566 1.6571 7.9988
HPAF-II GDSC2 4.4254 7.2337 2.1914 4.5113
KP-4 GDSC2 4.4615 7.7893 1.9517 5.8582
QGP-1 GDSC2 4.4917 7.3303 2.1886 4.3999
PL4 GDSC2 4.5595 6.9029 2.4275 2.917
KP-1N GDSC2 4.6024 6.9053 2.4514 2.7163
KP-2 GDSC2 4.8879 8.6596 1.8179 5.7954
Panc 08.13 GDSC2 4.9402 8.2386 2.0455 4.4051
Panc 10.05 GDSC2 5.2958 7.2996 2.6389 0.9947
AsPC-1 GDSC2 6.0101 8.4905 2.4884 1.0014
MZ-PC-1 GDSC2 6.3833 8.4607 2.6482 0.3652
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 3.9672 6.8227 2.0759 6.1961
MPP 89 GDSC2 4.0089 7.541 1.7539 8.0789
NCI-H28 GDSC2 4.3126 8.4826 1.5134 8.8122
IST-Mes1 GDSC2 4.5216 10.9458 0.4577 14.2938
NCI-H2052 GDSC2 6.2862 14.3062 0.0603 12.4104
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 3.446 12.4854 -1.1569 24.5892
22Rv1 GDSC2 3.7521 6.3984 2.1258 6.4087
VCaP GDSC2 4.1651 7.3415 1.9641 6.4251
DU145 GDSC2 4.1869 6.4437 2.4096 3.692
PC-3 GDSC2 4.7989 9.138 1.5336 7.6197
NCI-H660 GDSC2 5.0125 6.5986 2.7877 0.665
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 5.0189 9.7731 1.3774 8.0653
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IPC-298 GDSC2 1.6672 5.4678 0.6812 22.1069
G-361 GDSC2 2.9148 6.75 1.2578 14.2298
CP50-MEL-B GDSC2 3.1965 7.0112 1.3717 12.6571
HMV-II GDSC2 3.2804 6.315 1.7907 9.806
G-mel GDSC2 3.4104 5.4377 2.3368 5.9844
A101D GDSC2 3.4327 9.273 0.4382 17.3433
MZ-MEL-2 GDSC2 3.4849 6.5199 1.8567 8.8051
VMRC-MELG GDSC2 3.577 5.4449 2.4648 4.7294
Hs 940.T GDSC2 3.5884 7.6915 1.3551 11.6215
A-431 GDSC2 3.6404 7.2899 1.5967 9.9974
DJM-1 GDSC2 3.6667 5.7511 2.3813 5.0249
IGR-37 GDSC2 3.684 5.6822 2.4283 4.6886
M14 GDSC2 3.6918 6.2002 2.1782 6.2333
COLO 792 GDSC2 3.753 7.641 1.5103 10.2271
Mel JuSo GDSC2 3.7907 5.5147 2.5874 3.452
A-375 GDSC2 3.8191 6.3494 2.1999 5.7815
UACC-62 GDSC2 3.8639 5.9632 2.4212 4.3066
SK-MEL-24 GDSC2 3.8914 6.8263 2.0187 6.7313
COLO 800 GDSC2 3.935 8.1102 1.4176 10.3154
SH-4 GDSC2 4.0056 6.2787 2.3672 4.3221
RPMI-7951 GDSC2 4.0176 10.8512 0.1202 17.3407
SK-MEL-5 GDSC2 4.0222 5.5288 2.7331 2.1162
UACC-257 GDSC2 4.0318 5.9011 2.5651 3.0784
WM1552C GDSC2 4.0415 10.6626 0.2327 16.7048
WM35 GDSC2 4.0908 8.0662 1.5561 9.0862
SK-MEL-28 GDSC2 4.1182 6.6049 2.2873 4.5648
COLO 679 GDSC2 4.1217 6.1455 2.508 3.2392
LB373-MEL-D GDSC2 4.2495 6.0749 2.6201 2.3613
Mel Ho GDSC2 4.2533 7.3487 2.022 5.8784
SK-MEL-31 GDSC2 4.298 16.663 -2.5537 26.906
SK-MEL-2 GDSC2 4.3361 5.7819 2.7989 1.2812
CHL-1 GDSC2 4.3907 6.9695 2.2933 3.9809
Hs 938.T GDSC2 4.4282 7.4082 2.1109 4.9809
A-388 GDSC2 4.4454 10.167 0.7846 12.7122
MZ-MEL-7 GDSC2 4.4805 7.2774 2.2062 4.3183
GAK GDSC2 4.5328 7.8899 1.9511 5.7155
WT2-iPS GDSC2 4.5488 6.0415 2.7974 1.0372
SK-MEL-30 GDSC2 4.5873 6.0113 2.8283 0.8631
A2058 GDSC2 4.6421 12.4051 -0.1718 17.1418
LOX-IMVI GDSC2 4.757 8.9442 1.598 7.3316
WM115 GDSC2 4.7829 7.4555 2.3084 3.2096
SK-MEL-3 GDSC2 4.9354 7.3001 2.462 2.1766
HT-144 GDSC2 5.05 17.4168 -2.3422 24.4774
COLO 829 GDSC2 5.052 8.1714 2.1422 3.686
451Lu GDSC2 5.0988 7.4002 2.504 1.7694
CP66-MEL GDSC2 5.1433 6.4268 2.9043 0.2537
COLO 783 GDSC2 5.1897 6.891 2.7513 0.6668
RVH-421 GDSC2 5.2433 7.055 2.7112 0.7682
WM278 GDSC2 5.2834 8.2981 2.2158 2.9529
WM793 GDSC2 5.4419 7.2832 2.7083 0.6446
MMAc-SF GDSC2 5.4562 7.3556 2.6869 0.7051
LB2518-MEL GDSC2 5.5366 6.8483 2.9009 0.1449
IGR-1 GDSC2 5.6867 7.4422 2.7477 0.4052
EquiPSC Line K2 GDSC2 3.8583 7.0089 1.9041 7.5237
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 2.7305 5.303 1.8038 11.4779
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-402 GDSC2 0.811 8.6797 -1.657 35.4483
MES-SA GDSC2 3.3355 5.4501 2.2691 6.6263
Rh41 GDSC2 3.3947 4.8817 2.6018 4.3523
A-204 GDSC2 3.4478 15.6287 -2.7269 29.5812
SK-LMS-1 GDSC2 3.5838 5.0376 2.6713 3.4177
SW982 GDSC2 3.5959 6.6187 1.8959 8.2549
EW-8 GDSC2 3.6132 5.9616 2.2363 6.0713
SW872 GDSC2 3.8936 9.0481 0.9202 13.3612
SW684 GDSC2 3.9725 7.0258 1.9803 6.7731
Rh30 GDSC2 4.0156 6.6838 2.1782 5.4547
SK-UT-1 GDSC2 4.0613 6.1971 2.444 3.7404
HT-1080 GDSC2 4.1553 8.329 1.4744 9.4216
G-401 GDSC2 4.2299 15.8967 -2.2258 26.1062
STS-0421 GDSC2 4.2463 8.3772 1.5171 8.9462
VA-ES-BJ GDSC2 4.4927 7.9038 1.9179 5.9948
KYM-1 GDSC2 4.5976 8.2853 1.8059 6.4411
TE 441.T GDSC2 4.939 6.86 2.6497 1.2816
RD GDSC2 4.9552 11.2736 0.6113 12.4488
RKN GDSC2 5.3294 6.958 2.7839 0.4799
GCT GDSC2 5.6715 15.9408 -1.1527 18.9377
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KATO III GDSC2 1.1364 3.907 0.7548 23.9646
RERF-GC-1B GDSC2 2.2255 10.0643 -1.0016 27.8752
RF-48 GDSC2 2.9648 5.6794 1.8338 10.5091
SK-GT-2 GDSC2 3.3483 6.1757 1.9169 8.8138
AGS GDSC2 3.3555 5.8774 2.0721 7.8142
23132/87 GDSC2 3.4575 7.4649 1.3623 11.9468
SNU-1 GDSC2 3.4621 6.5676 1.8143 9.1344
SCH GDSC2 3.464 11.8427 -0.8207 23.2074
IM95 GDSC2 3.5262 7.0774 1.6116 10.2194
MKN45 GDSC2 3.593 6.6772 1.8645 8.4598
NCI-N87 GDSC2 3.5981 8.9392 0.74 15.2033
NUGC-4 GDSC2 3.6377 5.9307 2.2705 5.7931
ECC10 GDSC2 3.7763 6.0443 2.3184 5.1481
OCUM-1 GDSC2 3.8366 10.7058 0.0496 18.1903
HGC-27 GDSC2 3.8959 5.7959 2.5245 3.6041
MKN1 GDSC2 3.9161 6.9196 1.9911 6.8423
SNU-5 GDSC2 3.9947 9.404 0.8217 13.6527
Hs 746.T GDSC2 4.152 7.4196 1.9169 6.7425
ECC12 GDSC2 4.2498 8.0369 1.6859 7.9211
NUGC-3 GDSC2 4.4388 7.7087 1.975 5.7667
TMK-1 GDSC2 4.4447 7.0774 2.2771 3.9737
GCIY GDSC2 4.8545 7.2235 2.4517 2.3391
MKN28 GDSC2 4.9428 10.7371 0.8629 11.1156
MKN7 GDSC2 5.5186 8.1583 2.3963 1.7959
SNG-M GDSC2 3.7083 6.9201 1.8339 8.344
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8305C GDSC2 3.5465 5.8887 2.2205 6.3468
ML-1 [Human leukemia] GDSC2 3.7135 6.6188 1.9873 7.3725
K5 GDSC2 3.8255 6.3581 2.2003 5.7633
FTC-133 GDSC2 3.945 7.5532 1.7005 8.5648
BHT-101 GDSC2 3.9775 9.5782 0.7219 14.2584
TT2609-C02 GDSC2 4.0805 6.5238 2.3006 4.5649
8505C GDSC2 4.1671 8.9201 1.1921 11.0718
CAL-62 GDSC2 4.1778 6.2152 2.5111 3.1132
HTC-C3 GDSC2 4.2115 9.533 0.923 12.5169
KMH-2 GDSC2 4.7309 7.4957 2.2595 3.5653
ASH-3 GDSC2 4.7713 6.6344 2.6607 1.4155
IHH-4 GDSC2 4.8812 6.3272 2.8357 0.5907
B-CPAP GDSC2 5.2013 12.7273 0.0786 14.6072
WRO GDSC2 5.3727 15.2087 -1.011 19.0492
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHU-011 GDSC2 2.8024 8.2012 0.4368 19.3135
BB49-HNC GDSC2 2.8796 6.3023 1.4487 13.1774
DOK GDSC2 3.0435 9.0022 0.2465 19.5425
KON GDSC2 3.0561 5.7141 1.8977 9.8171
SAS GDSC2 3.0932 7.4557 1.0615 14.844
HO-1-N-1 GDSC2 3.1011 4.6534 2.4642 6.1087
FaDu GDSC2 3.1419 6.8187 1.4214 12.5183
KOSC-2 GDSC2 3.2498 7.7467 1.0492 14.438
BB30-HNC GDSC2 3.3244 6.2326 1.8687 9.1867
PCI-15A GDSC2 3.3311 6.1579 1.9116 8.8975
Detroit 562 GDSC2 3.4169 6.7431 1.6899 10.0408
NCI-H3118 GDSC2 3.4913 5.3239 2.4584 4.9946
PCI-04B GDSC2 3.5646 6.4707 1.9449 8.0323
OSC-19 GDSC2 3.5827 6.3242 2.0322 7.4351
BICR 10 GDSC2 3.6198 10.1552 0.1502 18.2995
Ca9-22 GDSC2 3.6652 5.4043 2.5511 3.9684
SCC-9 GDSC2 3.7438 7.7395 1.4541 10.5949
SAT [Human HNSCC] GDSC2 3.7577 8.8883 0.8931 13.8863
HSC-2 GDSC2 3.8792 5.4476 2.68 2.7013
LB771-HNC GDSC2 3.8846 7.9574 1.4548 10.2202
PCI-06A GDSC2 3.8905 7.24 1.8142 7.9999
HSC-3 GDSC2 3.9649 8.739 1.1288 11.9605
BICR 22 GDSC2 4.0657 7.6455 1.7444 7.9997
CAL-33 GDSC2 4.2116 7.8532 1.7481 7.6327
SCC-25 GDSC2 4.2648 6.9907 2.2013 4.7745
SKN-3 GDSC2 4.3701 8.478 1.5566 8.4211
SCC-4 GDSC2 4.4094 8.5004 1.5734 8.2313
BHY GDSC2 4.4675 6.3411 2.6263 1.9842
JHU-029 GDSC2 4.5627 8.0178 1.9101 5.8967
SCC-15 GDSC2 4.6492 7.0577 2.4099 2.8685
BICR 31 GDSC2 4.6533 6.8361 2.5111 2.3181
CAL-27 GDSC2 5.006 10.2632 1.1347 9.4662
BICR 78 GDSC2 5.0452 7.676 2.3578 2.5559
OSC-20 GDSC2 5.1551 13.9531 -0.5541 17.6408
JHU-022 GDSC2 5.5133 15.777 -1.1871 19.4239
HSC-4 GDSC2 5.6356 7.0481 2.8676 0.1741
UPCI-SCC-090 GDSC2 5.6611 14.1531 -0.2898 15.3211
PE/CA-PJ15 GDSC2 6.124 8.0374 2.701 0.3432
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC2 3.3592 6.5931 1.7173 10.0357
RT-112 GDSC2 3.3763 6.7473 1.6544 10.3785
639V GDSC2 3.4455 6.538 1.8157 9.1725
SW780 GDSC2 3.8654 11.9202 -0.5332 20.838
HT-1197 GDSC2 3.8747 9.5839 0.6388 14.9961
647V GDSC2 3.9402 6.4239 2.2511 5.1787
KU-19-19 GDSC2 3.9436 12.1851 -0.6028 20.926
CAL-29 GDSC2 3.9843 7.6316 1.6911 8.5249
SW1710 GDSC2 4.1359 7.1334 2.0446 6.0002
TCCSUP GDSC2 4.2789 7.4872 1.9728 6.1197
RT-4 GDSC2 4.3841 10.4201 0.6145 13.7976
J82 GDSC2 4.4808 9.5783 1.0991 10.8496
5637 GDSC2 5.3369 11.744 0.6488 11.4089
T24 GDSC2 6.1977 8.0044 2.7397 0.246
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 2.2336 3.7708 1.9873 12.2656
BPH-1 GDSC2 2.5973 11.5445 -1.4079 28.1015
CAL-39 GDSC2 2.6112 7.4061 0.661 18.7213
ACC-OV7 GDSC2 3.0416 11.1946 -0.8504 24.6009
DSH1 GDSC2 3.0906 5.33 2.1192 8.3147
NEC8 GDSC2 3.2967 6.0728 1.9254 8.9106
ME-180 GDSC2 3.4584 7.1235 1.5336 10.8929
C-33 A GDSC2 3.4743 5.9129 2.1511 6.9805
SiHa GDSC2 3.5114 6.0716 2.1016 7.1907
Ca Ski GDSC2 3.5562 7.5962 1.3768 11.5793
SKN GDSC2 3.6718 7.1928 1.6697 9.4613
PWR-1E GDSC2 3.7005 5.4672 2.5461 3.9147
HT-3 GDSC2 3.829 6.1943 2.2833 5.2398
HeLa GDSC2 3.8352 7.2673 1.759 8.4813
MS751 GDSC2 3.8836 6.1529 2.3428 4.7439
OVCA420 GDSC2 3.8979 8.0057 1.441 10.2694
HEC-1 GDSC2 3.9989 6.5372 2.2375 5.1286
JAR GDSC2 4.0081 6.4892 2.2672 4.9261
C-4-I GDSC2 4.0276 6.6003 2.2271 5.1278
SKG-IIIa GDSC2 4.0679 9.4686 0.846 13.3233
OMC-1 [Human cervical carcinoma] GDSC2 4.1807 6.8166 2.2281 4.7895
TC-YIK GDSC2 4.2278 6.5245 2.398 3.6803
DoTc2 4510 GDSC2 4.2424 8.7835 1.3151 10.1608
SiSo GDSC2 4.3499 8.4734 1.5445 8.5399
OV17R GDSC2 4.4134 7.4087 2.1009 5.0695
PEO1 GDSC2 4.4992 7.4294 2.1468 4.6295
LB831-BLC GDSC2 4.5171 12.1897 -0.1595 17.3973
SW756 GDSC2 4.5635 11.5738 0.1794 15.6246
JEG-3 GDSC2 4.6328 6.8505 2.4933 2.4435
OVMIU GDSC2 4.6491 8.911 1.5412 7.8926
UWB1.289 GDSC2 5.0085 9.0079 1.7315 6.0623
JHOS-3 GDSC2 5.1338 7.6841 2.4016 2.2189
OVCA433 GDSC2 5.2876 7.5681 2.5272 1.4601
SW954 GDSC2 5.557 7.9295 2.5074 1.2875
HEY GDSC2 5.8616 8.1552 2.5535 0.8814
SW962 GDSC2 6.3206 8.2174 2.7103 0.2645
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207.