Details of the Drug

General Information of Drug (ID: DMLDSX8)

Drug Name
TT-30
Synonyms CR2/factor H modulator (fusion protein, autoimmune/inflammatory disease), Alexion; CR2/factor H modulator (fusion protein, autoimmune/inflammatory disease), Taligen
Indication
Disease Entry ICD 11 Status REF
Autoimmune diabetes 5A10 Phase 1 [1]
Cross-matching ID
TTD ID
D01XQQ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Complement factor H (CFH) TTUW6OP CFAH_HUMAN Modulator [2]
Complement receptor type 2 (CD21) TT0HUN7 CR2_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01335165) Safety and Pharmacokinetics of TT30 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH). U.S. National Institutes of Health.
2 The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. Blood. 2012 Jun 28;119(26):6307-16.