Details of the Drug

General Information of Drug (ID: DMLEX1D)

Drug Name
Lexibulin
Synonyms
Lexibulin; CYT-997; Microtubule inhibitor (oral, solid tumors) Cytopia; VDA anticancer program (iv), Cytopia; Lexibulin (iv infusion, cancer), YM BioSciences; Lexibulin (oral capsule, cancer), YM Biosciences; CYT-997 (iv infusion, cancer), Cytopia; CYT-997 (iv infusion, cancer), YM BioSciences; CYT-997 (oral capsule, cancer), Cytopia; CYT-997 (oral capsule, cancer), YM Biosciences; Vascular disrupting agent/ tubulin inhibitor (iv, cancer), Cytopia; Vascular disrupting agent/tubulin inhibitor (oral, cancer), Cytopia; Vascular targeting agent/ tubulin inhibitor (iv, cancer), Cytopia
Indication
Disease Entry ICD 11 Status REF
Glioblastoma multiforme 2A00.0 Phase 2 [1]
Structure
3D MOL 2D MOL
Cross-matching ID
PubChem CID
11351021
UNII
2GTU230HA1
DrugBank ID
DB05147
TTD ID
D01JNE
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tubulin beta (TUBB) TTYFKSZ NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LN-229 CTRP1 -1.3754 4.7134 -2.764 46.9077
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP1 -2.7882 1.8273 -3.2265 59.8851
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NU-DUL-1 CTRP1 -4.0387 -3.1149 -4.0387 82.1915
SKM-1 CTRP1 -4.0184 -3.3177 -4.0184 82.1286
WSU-DLCL2 CTRP1 -3.8711 -3.3637 -3.8711 80.1071
PL21 CTRP1 -3.8398 -3.2772 -3.8398 79.654
OCI-AML-3 CTRP1 -3.8092 -3.2149 -3.8092 79.2136
SU-DHL-5 CTRP1 -3.798 -3.3477 -3.798 79.0683
GDM-1 CTRP1 -3.7343 -2.5886 -3.7343 77.7742
THP-1 CTRP1 -3.5907 -2.0651 -3.5913 75.2599
RPMI-8226 CTRP1 -3.5862 -2.7216 -3.5862 75.9665
U-937 CTRP1 -3.4587 -2.6675 -3.4587 74.1895
NOMO-1 CTRP1 -3.3995 -2.4233 -3.3995 73.2833
MOLM-16 CTRP1 -3.3687 -2.1363 -3.3689 72.6706
SU-DHL-4 CTRP1 -2.8723 -2.2818 -2.8723 65.8467
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 CTRP1 -3.8745 -2.7321 -3.8746 79.6676
SNU-81 CTRP1 -3.8639 -0.8809 -3.9071 74.4054
KM12 CTRP1 -3.8359 0.1795 -4.0014 70.9775
RKO CTRP1 -3.6434 -2.7808 -3.6434 76.7721
HCT 116 CTRP1 -3.5207 -2.3296 -3.5207 74.8044
SNU-C4 CTRP1 -2.992 -1.3916 -2.9942 67.1224
NCI-H508 CTRP1 -2.983 -0.7756 -3.0011 66.1463
SNU-C5 CTRP1 -2.9177 1.7256 -3.3398 61.0594
MDST8 CTRP1 -2.8501 11.5356 -7.3639 54.0461
SW948 CTRP1 -2.846 2.7812 -3.5843 59.0968
LoVo CTRP1 -2.7935 0.4016 -2.9171 62.131
HT115 CTRP1 -2.7589 -1.0391 -2.7639 63.8152
SNU-1040 CTRP1 -1.8342 0.2037 -1.8729 50.9712
CL-34 CTRP1 -1.7966 0.9435 -1.9353 50.4247
SNU-61 CTRP1 -1.4711 5.558 -3.2314 47.9226
HCT 8 CTRP1 -0.946 0.9354 -1.0176 38.7711
CW-2 CTRP1 -0.8392 4.0978 -1.9445 41.4638
HT-55 CTRP1 -0.6636 1.5391 -0.8316 35.3994
COLO 320 CTRP1 -0.247 7.5939 -2.9737 40.2719
CL-40 CTRP1 -0.1365 3.3796 -0.9087 32.0283
LS123 CTRP1 2.0709 9.7877 -2.0136 26.5872
RCM-1 [Human ESC] CTRP1 2.6248 8.848 -1.1085 19.7755
SW480 CTRP1 2.6518 10.6109 -1.9626 24.2304
COLO 678 CTRP1 3.6808 6.5999 0.6705 3.9299
HT-29 CTRP1 4.2277 14.0691 -2.4968 21.7421
SW620 CTRP1 4.3396 15.7241 -3.224 24.2498
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1836 CTRP1 -4.07 0.4318 -4.2976 71.6381
NCI-H2122 CTRP1 -3.5234 -1.9985 -3.5241 74.3765
NCI-H2073 CTRP1 -3.4431 15.804 -9.9721 54.7183
NCI-H596 CTRP1 -2.8115 -1.1467 -2.8153 64.5876
NCI-H1781 CTRP1 -2.2832 0.6565 -2.4097 56.3986
COR-L23 CTRP1 -1.8292 7.1238 -4.2996 50.3829
NCI-H460 CTRP1 -1.1933 4.6832 -2.5627 45.3352
HCC15 CTRP1 -0.8132 5.3169 -2.4559 42.5035
NCI-H1755 CTRP1 0.63 5.7936 -1.2744 29.471
T3M-10 CTRP1 1.6624 10.3727 -2.6432 30.69
SK-LU-1 CTRP1 1.8222 11.4146 -3.031 31.3925
NCI-H3255 CTRP1 3.837 6.3157 0.8706 2.3231
NCI-H2110 CTRP1 3.8925 14.418 -2.9092 24.3164
NCI-H441 CTRP1 4.1297 11.9973 -1.562 17.585
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TYK-nu CTRP1 -4.2719 15.0891 -10.4292 56.9807
OV-90 CTRP1 -2.7689 4.5691 -4.1648 56.8686
RMUG-S CTRP1 -2.0612 5.7075 -3.9021 51.9506
RMG-I CTRP1 -1.4767 6.9324 -3.8593 48.2507
COV644 CTRP1 -0.5176 5.5006 -2.2439 40.0794
SNU-840 CTRP1 1.2113 13.7069 -4.6915 37.5794
COV362 CTRP1 2.1907 11.5612 -2.8023 29.293
Caov-3 CTRP1 4.2805 16.0882 -3.4451 25.1658
OV7 CTRP1 5.5669 16.4067 -2.7041 19.2362
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-375 CTRP1 -3.2304 -0.0224 -3.3245 67.0156
SK-MEL-5 CTRP1 -1.5339 3.6173 -2.4776 47.929
SK-MEL-1 CTRP1 -0.2036 7.9924 -3.1256 40.3667
SK-MEL-28 CTRP1 3.1486 4.0873 1.4331 0.22
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1080 CTRP1 -2.7636 0.0012 -2.8321 62.4786

References

1 ClinicalTrials.gov (NCT00664378) Efficacy Study of CYT997 in Multiple Myeloma. U.S. National Institutes of Health.
2 National Cancer Institute Drug Dictionary (drug id 598799).