Details of the Drug

General Information of Drug (ID: DMLIAA7)

Drug Name
NX-13
Synonyms
Amelenodor; Amelenodor [INN]; NX-13 free base; DVH35H3HDB; 2389235-01-0; NX-13; UNII-DVH35H3HDB; 1,3,5-Tris((6-methylpyridin-2-yl)oxy)benzene; 2,2',2''-(1,3,5-Benzenetriyltris(oxy))tris(6-methylpyridine; 2,2',2''-(Benzene-1,3,5-triyltris(oxy))tris(6-methylpyridine); Pyridine, 2,2',2''-(1,3,5-benzenetriyltris(oxy))tris(6-methyl-; 2,2',2''-[1,3,5-Benzenetriyltris(oxy)]tris[6-methylpyridine; 2,2',2''-[benzene-1,3,5-triyltris(oxy)]tris(6-methylpyridine); Pyridine, 2,2',2''-[1,3,5-benzenetriyltris(oxy)]tris[6-methyl-; CHEMBL5095087; SCHEMBL22061849; AKOS040756180
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Phase 2 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C24H21N3O3
Canonical SMILES
CC1=NC(=CC=C1)OC2=CC(=CC(=C2)OC3=CC=CC(=N3)C)OC4=CC=CC(=N4)C
InChI
InChI=1S/C24H21N3O3/c1-16-7-4-10-22(25-16)28-19-13-20(29-23-11-5-8-17(2)26-23)15-21(14-19)30-24-12-6-9-18(3)27-24/h4-15H,1-3H3
InChIKey
OPUQKVNCXCWRLR-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
146651362
TTD ID
D4W2AC

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NLR family member X1 (NLRX1) TTKT026 NLRX1_HUMAN Agonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT05785715) A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Multicenter Phase 2 Induction Study With Long-Term Extension to Evaluate the Clinical Activity and Safety of Oral NX-13 in Participants w/ Moderate to Severe Ulcerative Colitis. U.S.National Institutes of Health.
2 Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1. Drug Chem Toxicol. 2022 Jan;45(1):209-214.