Details of the Drug

General Information of Drug (ID: DMLK59M)

Drug Name
AZD1480
Synonyms RET inhibitors
Indication
Disease Entry ICD 11 Status REF
Myeloproliferative syndrome 2A22 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 348.76
Logarithm of the Partition Coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C14H14ClFN8
IUPAC Name
5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Canonical SMILES
CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F
InChI
InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey
PDOQBOJDRPLBQU-QMMMGPOBSA-N
Cross-matching ID
PubChem CID
16659841
CAS Number
935666-88-9
UNII
KL2Z2TLF01
DrugBank ID
DB12588
TTD ID
D0MP0X
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Post-Translational Modifications [3]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Post-Translational Modifications [3]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Post-Translational Modifications [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 2.683 5.2209 0.356 3.8698
H-EMC-SS GDSC1 -0.8269 4.5819 -2.3218 34.8694
NY GDSC1 -0.1832 1.7873 -0.4677 20.725
CHSA0011 GDSC1 -0.041 3.1301 -0.8714 22.7826
HuO9 GDSC1 0.5478 3.3581 -0.3962 16.585
TC-71 GDSC1 0.6388 2.3203 0.1809 11.8219
CHSA0108 GDSC1 0.7505 6.1547 -1.5858 23.6247
CAL-72 GDSC1 0.8011 7.7086 -2.3152 27.1472
EW-7 GDSC1 0.929 2.9652 0.1536 10.7407
EW-11 GDSC1 0.9495 4.7901 -0.7315 17.3195
ES7 GDSC1 1.0137 3.2812 0.0749 11.0031
EW-18 GDSC1 1.0684 2.8123 0.3562 8.5867
MHH-ES-1 GDSC1 1.0847 2.8778 0.3384 8.6599
ES8 GDSC1 1.0873 3.218 0.1719 9.9526
EW-1 GDSC1 1.3067 3.26 0.3402 7.7964
EW-24 GDSC1 1.3648 2.5055 0.7655 4.2357
EW-3 GDSC1 1.3687 5.2697 -0.6131 14.8552
CHSA8926 GDSC1 1.4299 4.51 -0.1831 11.4304
ES5 GDSC1 1.4934 3.8805 0.1826 8.3765
U2OS GDSC1 1.5397 4.6509 -0.1647 10.906
NOS-1 [Human HNSCC] GDSC1 1.7492 10.3088 -2.8206 25.8575
EW-16 GDSC1 1.7987 6.7382 -0.9999 16.0164
ES4 GDSC1 1.873 4.9096 -0.036 8.836
EW-22 GDSC1 1.8808 4.4263 0.2073 6.9532
HuO-3N1 GDSC1 1.8995 6.2564 -0.6821 13.5076
Hs 888.T CTRP2 1.9079 9.8564 0.124 33.0612
SK-PN-DW GDSC1 1.9275 6.3969 -0.7303 13.7535
ES1 GDSC1 2.137 5.616 -0.1895 9.1974
EW-13 GDSC1 2.1943 6.0394 -0.3552 10.2458
CADO-ES1 GDSC1 2.2309 4.7278 0.3039 5.2665
ES6 GDSC1 2.3138 5.3066 0.0833 6.6837
SJSA-1 GDSC1 2.4348 5.7897 -0.0664 7.4653
G-292 clone A141B1 GDSC1; CTRP2 3.4155 5.9603 3.1979 18.2728
A-673 GDSC1; CTRP2 3.963 6.3383 3.6864 14.8468
SK-ES-1 GDSC1; CTRP2 4.3239 8.4285 3.2298 15.6228
MG-63 GDSC1; CTRP2 4.5212 13.3669 1.0474 23.2168
SK-N-MC CTRP2 4.528 6.6337 4.198 11.2958
TC71 CTRP2 5.2769 6.5427 5.0328 6.0119
SaOS-2 GDSC1; CTRP2 5.3878 7.1869 4.8635 6.3956
Hs 822.T CTRP2 5.7708 9.9817 3.8434 9.7878
HOS GDSC1; CTRP2 10.3509 21.4501 1.5668 11.2238
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 178 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 5.1537 7.74 4.3746 8.9511
JM1 GDSC1; CTRP2 3.5363 5.608 3.4128 17.134
DND-41 GDSC1; CTRP2 -14.7284 2.7093 -15.8098 82.8615
WSU-DLCL2 GDSC1 -4.2596 -3.2295 -4.2596 69.7352
L-1236 GDSC1 -3.0929 -0.4283 -3.1549 54.8091
SUP-M2 GDSC1 -2.7366 -0.2683 -2.7956 50.6911
SR GDSC1 -2.7207 -0.4354 -2.7625 50.5106
MOLM-13 GDSC1 -1.586 1.0765 -1.7881 37.4395
Karpas-299 GDSC1 -1.516 1.028 -1.7002 36.5044
A3/Kawakami GDSC1 -1.2582 1.3134 -1.4915 33.6399
DEL GDSC1 -1.2335 -0.3754 -1.2347 31.9503
MV4-11 GDSC1 -0.9957 1.6055 -1.2901 30.8034
TUR GDSC1 -0.8718 2.993 -1.6704 32.1791
GDM-1 GDSC1 -0.626 3.3356 -1.5602 30.164
L-540 GDSC1 -0.5143 3.3028 -1.4311 28.8138
CTV-1 GDSC1 -0.2491 2.1586 -0.6764 22.5282
ALL-SIL GDSC1 -0.1322 1.5428 -0.3304 19.4939
NB4 GDSC1 -0.1092 1.0663 -0.1783 18.3353
Mono-Mac-6 GDSC1 -0.0712 5.0948 -1.8221 28.6314
HDLM-2 GDSC1 -0.0682 4.6175 -1.5909 27.3819
MOLM-16 GDSC1 -0.0218 4.688 -1.5797 27.0907
ATN-1 GDSC1 0.0228 5.4579 -1.9082 28.6121
SET-2 CTRP2 0.2341 3.5205 0.1739 38.8903
MOLT-4 GDSC1 0.2624 2.139 -0.1274 15.9531
Reh GDSC1 0.2672 2.2326 -0.1617 16.1782
CCRF-CEM GDSC1 0.3452 3.8067 -0.8055 20.459
HEL GDSC1 0.3784 2.657 -0.2341 16.1653
P32/ISH GDSC1 0.4205 1.5583 0.2648 12.3135
P30/OHK GDSC1 0.4505 1.9297 0.1563 12.931
SU-DHL-5 GDSC1 0.5125 3.5393 -0.517 17.6341
EHEB GDSC1 0.6177 32.1322 -14.6739 44.3169
CTB-1 GDSC1 0.6357 7.9878 -2.5988 29.0448
BC-1 GDSC1 0.6895 3.5868 -0.3728 15.7853
EM-2 GDSC1 0.7291 2.0544 0.3921 9.8076
CRO-AP2 GDSC1 0.7838 2.2306 0.367 9.7371
MHH-CALL-2 GDSC1 0.8093 2.4518 0.2884 10.2197
NKM-1 GDSC1 0.8518 3.2274 -0.0463 12.6108
BE-13 GDSC1 0.9104 2.2828 0.4666 8.4002
697 GDSC1 0.9337 4.6602 -0.6809 17.023
NALM-6 GDSC1 0.9862 2.3486 0.5076 7.7512
H9 GDSC1 0.991 5.5689 -1.0832 19.5539
Karpas-620 GDSC1 1.0471 5.1133 -0.8074 17.4624
KY821 GDSC1 1.0592 2.6225 0.4415 7.9569
JVM-3 GDSC1 1.1337 3.6646 -0.0097 11.188
HAL-01 GDSC1 1.1384 3.9393 -0.1426 12.1981
U-698-M GDSC1 1.183 4.8993 -0.5838 15.3394
Pfeiffer CTRP2 1.1985 5.5079 0.8922 33.2711
JVM-2 GDSC1 1.2187 3.642 0.0748 10.2055
Karpas-45 GDSC1 1.2389 3.1572 0.3342 8.0945
SU-DHL-6 GDSC1 1.2429 2.7977 0.5172 6.6381
Ku812 GDSC1 1.2558 6.2263 -1.1856 19.1811
RPMI-8402 GDSC1 1.267 3.8818 -0.0041 10.6399
RS4;11 GDSC1 1.2766 4.5063 -0.3082 12.9394
BV-173 GDSC1 1.283 3.6998 0.1004 9.7656
SU-DHL-16 GDSC1 1.29 2.6084 0.6519 5.4012
BL-41 GDSC1 1.3251 2.7837 0.5937 5.7313
Jiyoye GDSC1 1.3423 7.4348 -1.7175 22.0272
KOPN-8 GDSC1 1.3565 5.4566 -0.7167 15.64
ML-2 GDSC1 1.3722 3.2698 0.3896 7.1718
ALL-PO GDSC1 1.397 4.6645 -0.2872 12.3403
MOLT-16 GDSC1 1.4161 3.5627 0.279 7.8873
M-07e CTRP2 1.4284 6.4167 0.9005 32.4583
MEG-01 GDSC1 1.4392 3.8875 0.1355 8.9311
RCH-ACV GDSC1 1.4915 4.3688 -0.0626 10.2882
JSC-1 GDSC1 1.4933 4.4686 -0.111 10.6553
HC-1 GDSC1 1.4938 4.6653 -0.2088 11.4016
Karpas-1106P GDSC1 1.4972 6.2412 -0.9932 17.0284
MHH-PREB-1 GDSC1 1.5128 4.7832 -0.2524 11.6661
LC4-1 GDSC1 1.5254 4.1143 0.0915 8.9781
AMO1 GDSC1 1.5782 7.2994 -1.456 19.66
MOLT-13 GDSC1 1.5955 5.4074 -0.4975 13.2054
Loucy GDSC1 1.602 3.6188 0.3978 6.3335
YT GDSC1 1.6818 5.8206 -0.635 13.9019
MLMA GDSC1 1.6927 6.2557 -0.8432 15.3225
CML-T1 GDSC1 1.7003 7.1022 -1.2592 18.0262
Karpas-231 GDSC1 1.714 3.8588 0.3635 6.2496
F-36P CTRP2 1.7181 6.4376 1.21 30.5159
KMS-11 GDSC1 1.723 7.5172 -1.4481 19.1013
NCI-H929 GDSC1 1.7289 4.6201 -0.0015 9.0258
MC116 GDSC1 1.7416 9.527 -2.4364 24.2207
GR-ST GDSC1 1.8028 4.6281 0.0505 8.3932
SKM-1 GDSC1 1.803 4.8317 -0.05 9.1609
Jurkat GDSC1 1.8219 6.6569 -0.9412 15.5464
WSU-NHL GDSC1 1.8465 4.9134 -0.0576 9.083
IM-9 GDSC1 1.8753 3.4906 0.6569 3.5471
OCI-AML-2 GDSC1 1.8817 4.2742 0.2823 6.3753
L-363 GDSC1 1.8836 4.3858 0.2291 6.7779
KMOE-2 GDSC1 1.9169 4.1742 0.3561 5.7107
DG-75 GDSC1 1.9228 4.8674 0.0216 8.246
SK-MM-2 GDSC1 1.9762 4.4426 0.2675 6.2179
CESS GDSC1 2.0005 4.2748 0.3656 5.407
HH [Human lymphoma] GDSC1 2.0316 5.8246 -0.3689 10.8362
Namalwa GDSC1 2.0385 4.1375 0.4572 4.618
QIMR-WIL GDSC1 2.0751 4.8374 0.1455 6.8647
EoL-1 GDSC1; CTRP2 2.0834 3.442 2.0814 26.3953
RPMI-8226 GDSC1 2.0858 4.7215 0.209 6.3563
SU-DHL-10 GDSC1 2.1036 3.3084 0.8796 1.4767
KCL-22 GDSC1 2.1057 4.2661 0.4406 4.5705
P31/FUJ GDSC1 2.1163 5.0054 0.0928 7.1466
THP-1 GDSC1 2.122 7.6179 -1.1867 16.1564
SUP-B8 GDSC1 2.1746 8.7041 -1.6848 18.9572
KE-37 GDSC1 2.1748 7.8291 -1.2511 16.391
ARH-77 GDSC1 2.2367 5.0415 0.1582 6.3315
VAL GDSC1 2.239 4.4651 0.4331 4.2997
Ramos.2G6.4C10 GDSC1 2.2622 4.3857 0.4847 3.8722
OCI-M1 GDSC1; CTRP2 2.2626 3.1819 2.2625 25.1954
HT GDSC1 2.2835 5.6356 -0.0956 8.0865
Raji GDSC1 2.2988 3.9655 0.6981 2.3098
TK [Human B-cell lymphoma] GDSC1 2.3155 4.1513 0.6244 2.7761
ME1 GDSC1 2.3239 6.2687 -0.3743 10.0073
OCI-Ly7 GDSC1 2.3342 4.134 0.643 2.6122
Sc-1 GDSC1 2.3419 7.6135 -1.0196 14.3947
PL-21 GDSC1 2.3745 6.8899 -0.6411 11.7485
CA46 GDSC1 2.3991 5.7578 -0.0752 7.6242
SUP-HD1 GDSC1; CTRP2 2.4047 8.2923 1.293 28.0783
CMK GDSC1; CTRP2 2.4174 4.2435 2.3966 24.2333
SU-DHL-8 GDSC1 2.4229 5.237 0.1883 5.6381
SUP-T1 GDSC1 2.4367 7.413 -0.8519 13.0027
P12-Ichikawa GDSC1 2.4404 4.9869 0.3165 4.6707
OPM-2 GDSC1; CTRP2 2.4511 3.9098 2.4452 23.9587
BALL-1 GDSC1 2.4658 4.6211 0.4999 3.3249
NOMO-1 GDSC1 2.5007 7.3242 -0.7626 12.2145
JURL-MK1 GDSC1 2.52 4.369 0.643 2.2695
MN-60 GDSC1 2.5776 4.8283 0.4716 3.2938
WIL2 NS GDSC1 2.582 4.052 0.8092 1.1839
Hs 445 GDSC1 2.6561 4.6313 0.6023 2.2956
OCI-AML-5 GDSC1; CTRP2 2.686 4.8976 2.6169 22.6081
HuT 78 CTRP2 2.7434 7.301 2.0347 24.504
VL51 GDSC1 2.8409 7.8931 -0.8001 11.5151
LAMA-84 GDSC1 2.8531 9.6352 -1.638 16.6284
EB2 GDSC1 2.8877 4.5359 0.7569 1.0962
TF-1 CTRP2 2.9804 6.3395 2.6155 21.6967
SU-DHL-4 GDSC1 3.1387 4.66 0.8174 0.6058
NU-DUL-1 GDSC1 3.1976 5.5089 0.5079 2.0423
KM-H2 GDSC1 3.2162 11.6751 -2.3735 19.4104
A4/Fukuda GDSC1; CTRP2 3.2474 5.5383 3.1137 19.0938
ROS-50 GDSC1 3.3663 8.6599 -0.8152 10.2675
Farage GDSC1 3.3709 4.9099 0.8179 0.4576
RC-K8 GDSC1 3.4351 5.0187 0.8034 0.4678
OCI-Ly3 CTRP2 3.5624 5.4773 3.4668 16.8626
Kasumi-1 GDSC1; CTRP2 3.7536 6.0686 3.5377 16.0176
MOLP-8 GDSC1; CTRP2 3.8388 8.9938 2.4845 19.781
GA-10 GDSC1; CTRP2 3.8644 5.304 3.819 14.6775
PF-382 GDSC1 3.8666 5.4309 0.8185 0.2461
KO52 CTRP2 3.9192 6.5409 3.5727 15.3959
HEL 92.1.7 CTRP2 3.9336 6.1572 3.7091 14.8517
JeKo-1 GDSC1; CTRP2 3.989 7.1726 3.4169 15.7848
SEM CTRP2 4.063 6.1909 3.8404 13.9843
EB1 CTRP2 4.0829 6.8373 3.6448 14.6535
L-428 GDSC1; CTRP2 4.1075 7.6924 3.3303 15.7944
OCI-Ly19 GDSC1; CTRP2 4.1394 7.0109 3.6399 14.513
SUP-B15 CTRP2 4.1783 7.7157 3.3941 15.3563
Daudi GDSC1; CTRP2 4.1785 6.3693 3.9109 13.3819
Hs 611.T CTRP2 4.3793 8.6264 3.1953 15.6187
MOTN-1 CTRP2 4.3821 8.0576 3.4551 14.5809
KMS-20 CTRP2 4.3926 7.1263 3.8633 12.9534
U266B1 GDSC1; CTRP2 4.454 11.0669 2.1098 19.6569
AML-193 CTRP2 4.4966 8.3229 3.4516 14.3023
Granta-519 GDSC1; CTRP2 4.5554 7.9524 3.6784 13.2484
ST486 GDSC1; CTRP2 4.5805 6.3032 4.3693 10.5037
JJN-3 GDSC1; CTRP2 4.6905 10.6204 2.549 17.4189
RPMI-6666 GDSC1; CTRP2 4.7111 6.9909 4.2542 10.5706
OCI-AML-3 GDSC1; CTRP2 4.7684 6.3746 4.5495 9.2844
SIG-M5 CTRP2 4.7702 5.7993 4.7123 8.6876
K-562 GDSC1; CTRP2 4.7862 6.8507 4.3902 9.8395
Mino CTRP2 4.8251 5.7675 4.7778 8.2851
LP-1 GDSC1; CTRP2 5.0655 7.8288 4.2462 9.6875
NU-DHL-1 CTRP2 5.0836 9.0506 3.681 11.9534
Kasumi-2 CTRP2 5.3078 7.3858 4.6919 7.2873
Karpas-422 GDSC1; CTRP2 5.3559 7.9833 4.4548 8.1412
HL-60 GDSC1; CTRP2 5.4355 7.0801 4.9604 5.886
EJM GDSC1; CTRP2 5.4752 10.424 3.3638 12.3918
BL-70 CTRP2 5.5344 6.2894 5.4059 3.8654
OCI-Ly10 CTRP2 6.0147 7.6717 5.2058 3.5825
DB GDSC1; CTRP2 6.2074 9.6847 4.3583 6.7783
RL GDSC1; CTRP2 6.5792 10.2877 4.3503 6.152
HD-MY-Z CTRP2 6.6258 9.3345 4.8551 3.9825
Ci-1 CTRP2 7.4997 8.6035 5.6825 0.1798
⏷ Show the Full List of 178 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 4.0789 7.7216 3.2881 16.0356
TE-9 GDSC1 0.2784 4.2247 -1.07 22.5557
KYSE-270 GDSC1 0.9652 2.6377 0.3473 9.0834
TE-8 GDSC1 1.2462 4.8757 -0.5185 14.6217
KYSE-140 GDSC1 1.3857 4.7338 -0.3311 12.7123
T.T GDSC1 1.6513 3.4767 0.5052 5.3418
TE-10 GDSC1 1.6626 4.9206 -0.202 10.7735
KYSE-410 GDSC1 2.1004 5.4372 -0.1285 8.851
COLO 680N GDSC1 2.1646 4.2581 0.4827 4.1157
KYSE-180 GDSC1 2.1809 7.0938 -0.8832 13.9902
TE-4 GDSC1 2.3325 11.6906 -3.0462 24.8998
TE-6 GDSC1 2.6454 5.2749 0.3092 4.2702
TE-1 GDSC1 3.2027 5.3051 0.5939 1.5674
KYSE-70 GDSC1 3.4067 12.2895 -2.5364 19.6515
TE-15 GDSC1 3.5201 6.2577 0.3559 2.4583
TE-11 GDSC1; CTRP2 4.8001 7.4963 4.1307 10.8195
OE33 GDSC1; CTRP2 6.0415 10.3379 3.8952 9.0335
TE-5 GDSC1; CTRP2 6.1281 9.8626 4.2047 7.5714
OE21 GDSC1; CTRP2 6.2709 12.5333 2.9867 12.3317
KYSE-510 GDSC1; CTRP2 6.2853 7.792 5.3623 2.4343
KYSE-520 GDSC1; CTRP2 6.3109 8.6196 4.9716 4.0207
OE19 GDSC1; CTRP2 6.4583 8.7776 5.0055 3.6299
KYSE-30 CTRP2 6.501 8.3333 5.2546 2.5354
EC-GI-10 GDSC1; CTRP2 6.5144 12.9095 2.9952 11.8433
KYSE-150 GDSC1; CTRP2 6.75 9.1338 5.0408 3.0353
TE-14 CTRP2 6.8428 9.8912 4.7389 4.1245
KYSE-450 GDSC1; CTRP2 8.092 13.9359 3.6469 6.714
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.8592 9.4179 4.9789 3.1286
BxPC-3 GDSC1 1.1364 3.1158 0.266 9.0231
HuP-T4 GDSC1 1.2572 3.3881 0.2344 8.8111
KP-3 GDSC1 1.3151 3.9084 0.023 10.252
MZ-PC-1 GDSC1 1.3489 6.354 -1.1716 18.7407
PL4 GDSC1 1.3967 2.9782 0.5552 5.7812
KP-1N GDSC1 1.455 4.2986 -0.057 10.373
HPAC GDSC1 1.7082 8.0691 -1.7354 20.805
YAPC GDSC1 1.7168 5.1895 -0.2934 11.2825
SU.86.86 GDSC1 1.9179 5.7424 -0.4134 11.5186
KP-4 GDSC1 1.938 16.3104 -5.6653 33.5083
PaTu 8902 GDSC1 1.9586 4.5956 0.1806 6.9299
HPAF-II GDSC1 2.1161 9.6454 -2.1979 21.8437
QGP-1 GDSC1 2.1214 10.256 -2.4976 23.241
CFPAC-1 GDSC1 2.1748 4.0225 0.5989 3.2525
Capan-1 GDSC1 2.2025 4.2036 0.5321 3.6686
SUIT-2 GDSC1 2.6064 8.417 -1.2204 14.8771
SW1990 GDSC1; CTRP2 5.3926 8.9347 4.0256 9.8321
Panc 08.13 GDSC1; CTRP2 5.71 8.6219 4.4673 7.304
KP-2 GDSC1; CTRP2 5.8953 8.3774 4.7515 5.7294
Capan-2 GDSC1; CTRP2 5.902 7.163 5.3624 3.154
Hs 766T GDSC1; CTRP2 5.982 9.2431 4.3928 7.0633
PaTu 8988s CTRP2 6.013 9.369 4.3559 7.1576
MIA PaCa-2 GDSC1; CTRP2 6.0569 8.6777 4.7381 5.4666
DAN-G GDSC1; CTRP2 6.2911 7.9369 5.2951 2.7043
Panc 10.05 GDSC1; CTRP2 6.4019 8.1664 5.2646 2.6492
Panc 03.27 GDSC1; CTRP2 6.5937 9.1749 4.91 3.8069
AsPC-1 GDSC1; CTRP2 6.6316 11.8534 3.6136 9.1167
Panc 04.03 GDSC1; CTRP2 6.6646 9.2062 4.9458 3.5493
Panc 02.03 GDSC1; CTRP2 6.6877 8.6442 5.2336 2.3481
HuP-T3 GDSC1; CTRP2 6.7629 10.9757 4.1489 6.6802
PSN1 GDSC1; CTRP2 7.122 11.1467 4.326 5.3876
PaTu 8988t GDSC1; CTRP2 7.1902 8.6494 5.5274 0.7252
PK-45H CTRP2 7.3842 15.247 2.5064 12.2314
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 70 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 9.5238 26.6865 -1.5401 21.097
SK-MEL-5 GDSC1 -0.1067 4.5528 -1.5974 27.6096
SH-4 GDSC1 -0.0518 16.562 -7.4711 41.5924
G-mel GDSC1 0.6536 3.9053 -0.5617 17.3368
A-388 GDSC1 0.8756 2.938 0.1173 11.2473
A-431 GDSC1 1.056 5.5122 -0.9987 18.735
CHL-1 GDSC1 1.1728 4.0855 -0.186 12.3991
RPMI-7951 GDSC1 1.3672 3.6217 0.2095 8.6053
A-375 GDSC1 1.3938 2.8797 0.6021 5.4223
CP50-MEL-B GDSC1 1.5038 3.2498 0.505 5.8131
WM1552C GDSC1 1.556 3.8953 0.2247 7.8359
Mel JuSo GDSC1 1.5626 3.7215 0.3163 7.0982
LB373-MEL-D GDSC1 1.7765 3.8362 0.4206 5.6206
IST-MEL1 GDSC1 1.7919 4.3969 0.1563 7.613
SK-MEL-28 GDSC1 1.9257 3.1307 0.8574 1.9683
MZ-MEL-2 GDSC1 1.9425 4.3227 0.302 6.0509
GAK GDSC1 1.9596 4.1665 0.3896 5.3372
M14 GDSC1 1.9676 4.702 0.1351 7.2498
COLO 783 GDSC1 2.0101 3.6813 0.6546 3.2301
IPC-298 GDSC1 2.0236 4.7145 0.1689 6.8329
HMV-II GDSC1 2.0416 4.371 0.3475 5.4329
CP66-MEL GDSC1 2.0503 4.4684 0.3065 5.7183
Hs 938.T GDSC1 2.0958 4.1612 0.4838 4.2755
VMRC-MELG GDSC1 2.1088 4.2493 0.4506 4.4885
DJM-1 GDSC1 2.1266 4.9975 0.1039 7.0343
WM35 GDSC1 2.1477 12.4121 -3.5509 27.321
COLO 679 GDSC1 2.2395 7.6771 -1.1272 15.405
SK-MEL-31 GDSC1 2.2638 5.1777 0.1113 6.6082
WM278 GDSC1 2.2798 4.7115 0.3435 4.8547
G-361 GDSC1 2.293 4.093 0.6376 2.7308
SK-MEL-30 GDSC1 2.3547 9.0068 -1.6974 18.4558
WM793 GDSC1 2.5123 4.7462 0.4707 3.4312
Mel Ho GDSC1 2.5862 5.5431 0.1489 5.5327
LB2518-MEL GDSC1 2.7575 12.6617 -3.2006 24.2441
MMAc-SF GDSC1 2.7753 5.5108 0.2789 4.2088
451Lu GDSC1 3.0725 5.0411 0.6396 1.4841
SK-MEL-1 GDSC1 3.2524 4.8258 0.8018 0.5845
SK-MEL-24 GDSC1 3.3457 15.4098 -4.1148 25.8304
MZ-MEL-7 GDSC1 3.78 5.7152 0.6848 0.6555
COLO 792 GDSC1; CTRP2 4.105 7.603 3.3652 15.6659
Hs 688(A).T CTRP2 5.1615 8.1155 4.2049 9.6238
Hs 940.T GDSC1; CTRP2 5.2308 9.9892 3.3588 12.9433
CJM [Human melanoma] CTRP2 5.3504 9.1558 3.8783 10.5364
LOX-IMVI GDSC1; CTRP2 5.4726 8.3938 4.3647 8.2474
Hs 895.T CTRP2 5.5458 7.6943 4.7743 6.3859
Hs 934.T CTRP2 5.6612 8.4696 4.4993 7.2739
HMCB CTRP2 5.8101 9.3339 4.2005 8.2138
WM88 CTRP2 6.0825 7.8487 5.1738 3.5863
SK-MEL-3 GDSC1; CTRP2 6.511 7.8312 5.5035 1.5148
A2058 GDSC1; CTRP2 6.5151 7.423 5.6967 0.7643
MeWo GDSC1; CTRP2 6.5911 10.5559 4.2265 6.6467
IGR-39 CTRP2 6.6017 9.1796 4.9135 3.7797
IGR-1 GDSC1; CTRP2 6.6846 10.051 4.5463 5.1635
WT2-iPS GDSC1; CTRP2 6.7128 9.1484 5.008 3.2229
IGR-37 GDSC1; CTRP2 6.7293 9.1091 5.0385 3.0748
Hs 294T CTRP2 6.7319 9.9022 4.6542 4.6427
COLO 829 GDSC1; CTRP2 6.7915 9.5336 4.8764 3.6411
UACC-257 GDSC1; CTRP2 6.7969 8.9654 5.1534 2.5174
Hs 839.T CTRP2 6.8453 10.6256 4.3821 5.5837
UACC-62 GDSC1; CTRP2 6.9048 8.5402 5.4197 1.3569
K029AX CTRP2 7.0234 10.3171 4.6587 4.184
HT-144 GDSC1; CTRP2 7.0583 9.9687 4.8493 3.3706
SK-MEL-2 GDSC1; CTRP2 7.0637 7.8869 5.7726 0.1591
A101D GDSC1; CTRP2 7.0889 10.8095 4.4661 4.8678
COLO 800 GDSC1; CTRP2 7.0956 11.5166 4.1272 6.2376
WM983B CTRP2 7.2458 11.501 4.2408 5.5492
WM266-4 CTRP2 7.2533 11.269 4.358 5.0652
WM115 GDSC1; CTRP2 7.3693 12.7968 3.6986 7.5561
RVH-421 GDSC1; CTRP2 7.8775 12.893 4.0009 5.6195
EquiPSC Line K2 GDSC1 2.5968 5.406 0.2193 5.0075
⏷ Show the Full List of 70 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC1 -0.5543 2.8459 -1.2767 28.1238
KYSE-220 GDSC1 0.5124 6.5679 -2.0029 26.8617
HCE-4 GDSC1 1.182 4.7016 -0.4859 14.6247
ESO-26 GDSC1 1.6371 4.2053 0.1337 8.278
KYSE-50 GDSC1 1.8897 8.5903 -1.8506 20.8096
SK-GT-4 GDSC1 1.9398 5.0075 -0.0348 8.623
OACP4 C GDSC1 2.3411 6.3234 -0.3887 10.0616
ESO-51 GDSC1 2.5707 8.1569 -1.119 14.3474
OACM5.1 C GDSC1 2.6122 6.4273 -0.252 8.3421
KYAE-1 GDSC1 2.6901 5.8654 0.064 5.8949
TE-12 GDSC1 2.7779 6.5713 -0.2112 7.633
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; CTRP2 6.4117 8.6277 5.0446 3.5446
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB1 GDSC1 -1.8389 0.52 -1.9464 40.0516
SJNB-14 GDSC1 -0.8772 1.1838 -1.0418 28.5391
GI-ME-N GDSC1 0.2695 3.5806 -0.7711 20.5734
NH-12 GDSC1 0.3093 15.0454 -6.401 39.3441
IMR-5 GDSC1 0.4954 2.6455 -0.1116 14.6964
GOTO GDSC1 0.7318 2.807 0.0444 12.4332
Kelly GDSC1 0.7547 4.2697 -0.6478 17.5271
SJNB-5 GDSC1 0.8683 2.38 0.3797 9.2554
NB69 GDSC1 0.9059 2.5899 0.3149 9.5887
SJNB-10 GDSC1 1.016 10.1241 -3.3366 30.3394
TGW GDSC1 1.2561 2.9945 0.4302 7.2745
SiMa GDSC1 1.4353 4.8382 -0.3426 12.6202
SK-N-BE(2)-M17 GDSC1 1.5759 4.0361 0.1702 8.1955
SJNB-17 GDSC1 1.5895 5.7322 -0.6644 14.4315
CHP-126 GDSC1 2.0168 5.9975 -0.465 11.582
SJNB-7 GDSC1 2.0689 7.1162 -0.9786 14.9818
SK-N-AS GDSC1 2.0754 4.1937 0.455 4.5404
LA-N-6 GDSC1 2.1354 5.224 0.0003 7.7869
SK-N-MC-IXC GDSC1 2.2254 3.6158 0.8116 1.7006
SJNB-13 GDSC1 2.3238 4.3139 0.5555 3.2353
SJNB-12 GDSC1 2.3281 6.9301 -0.6943 12.2541
SJNB-6 GDSC1 2.4862 4.4433 0.5915 2.6662
IMR-32 CTRP2 2.5859 3.1624 2.5859 23.041
NH-6 CTRP2 3.0896 5.8091 2.8808 20.4096
NB(TU)1 GDSC1 3.3149 5.081 0.7318 0.8082
SK-N-SH GDSC1; CTRP2 3.3943 6.7729 2.925 19.3338
SK-N-DZ GDSC1; CTRP2 3.5189 8.6386 2.3148 21.2754
SK-N-BE(2) CTRP2 4.5982 7.8024 3.7889 12.6987
SK-N-FI GDSC1; CTRP2 4.6541 7.336 4.0501 11.5205
KP-N-YN GDSC1; CTRP2 5.5274 7.0663 5.0575 5.2671
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 1.2251 4.1536 -0.1754 12.1203
SNU-869 CTRP2 13.7449 36.856 -3.5128 19.8602
Cancer Drug Sensitivity Data Curated from 84 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFM-223 GDSC1 -1.8275 2.7677 -2.5954 42.1533
OCUB-M GDSC1 -1.5704 -0.4985 -1.573 36.1698
HCC70 GDSC1 -0.1467 3.3035 -1.0565 24.5528
MDA-MB-415 GDSC1 0.0219 6.5868 -2.4594 31.1201
Evsa-T GDSC1 0.0273 1.2052 -0.0608 16.756
MCF-7 GDSC1 0.4178 2.8848 -0.2993 16.4621
HCC1806 GDSC1 0.7823 2.9122 0.042 12.2291
CAL-51 GDSC1 0.7915 4.1506 -0.5556 16.7036
CAL-120 GDSC1 0.872 5.1773 -0.9925 19.4362
HCC1187 GDSC1 0.9616 2.5094 0.4065 8.6402
EFM-19 GDSC1 1.2442 8.353 -2.2586 25.1694
JIMT-1 GDSC1 1.2536 2.6912 0.5795 6.1073
HCC1395 GDSC1 1.2798 6.0097 -1.0572 18.2571
CAMA-1 GDSC1 1.577 3.4032 0.4855 5.7279
MDA-MB-231 GDSC1 1.6813 3.8282 0.3542 6.4232
HDQ-P1 GDSC1 1.7003 3.9728 0.2971 6.8078
HCC1143 GDSC1 1.7061 4.4471 0.0668 8.5727
COLO 824 GDSC1 1.7737 4.5554 0.0645 8.3759
MDA-MB-330 GDSC1 1.8641 4.6737 0.0737 8.0266
Hs 578T GDSC1; CTRP2 1.9265 7.6078 1.044 30.3702
ZR-75-30 GDSC1; CTRP2 1.9804 5.4402 1.7584 27.8303
MRK-nu-1 GDSC1 2.1331 5.5745 -0.1721 9.0795
HCC2157 GDSC1 2.1496 6.5993 -0.6628 12.5767
MDA-MB-436 GDSC1 2.39 6.7078 -0.5411 11.0047
MDA-MB-175-VII GDSC1 2.4994 9.5697 -1.8665 18.9335
UACC-893 GDSC1 2.6652 6.7627 -0.3768 9.0874
MDA-MB-361 GDSC1; CTRP2 2.8259 5.4825 2.6678 21.9854
HCC1937 GDSC1 2.9547 5.9102 0.2033 4.36
HCC1569 GDSC1 3.1813 6.0554 0.2662 3.5267
HCC1954 GDSC1 3.3036 15.5674 -4.2243 26.2794
HCC1419 GDSC1; CTRP2 3.9488 14.8117 -0.1883 28.2128
DU4475 GDSC1; CTRP2 4.021 7.3592 3.3769 15.8494
BT-483 GDSC1 4.1028 5.8307 0.7655 0.2821
BT-474 GDSC1; CTRP2 4.1207 6.4612 3.818 13.8954
HCC1599 GDSC1 4.1523 21.6882 -6.6093 30.168
MDA-MB-468 GDSC1; CTRP2 4.7618 6.367 4.5449 9.3208
MDA-MB-157 GDSC1; CTRP2 4.9248 9.6636 3.234 14.1448
Hs 578Bst CTRP2 5.9708 8.4012 4.8041 5.3573
T-47D GDSC1; CTRP2 5.9965 11.3104 3.3714 11.2952
BT-549 GDSC1; CTRP2 6.0054 9.7565 4.1557 8.0125
HCC202 GDSC1; CTRP2 6.0143 9.6768 4.203 7.7969
AU565 GDSC1; CTRP2 6.1575 10.9482 3.6861 9.6824
MDA-MB-453 GDSC1; CTRP2 6.2694 10.6522 3.9252 8.4763
BT-20 GDSC1; CTRP2 6.2962 8.1171 5.2097 3.0518
HCC38 GDSC1; CTRP2 6.3405 9.4077 4.6027 5.512
CAL-85-1 GDSC1; CTRP2 6.5701 12.114 3.4358 9.9557
HCC1428 GDSC1; CTRP2 6.6553 10.6613 4.2232 6.5514
HCC1500 GDSC1; CTRP2 7.2687 13.5831 3.2403 9.5564
EFM-192A GDSC1; CTRP2 7.3426 10.0949 4.9716 2.5336
HCC2218 GDSC1; CTRP2 7.3885 10.8539 4.6463 3.732
BT 271 CTRP2 1.6024 14.1985 -2.1419 38.4556
BT 440 CTRP2 2.6844 5.5177 2.5067 22.996
BT 172 CTRP2 3.7855 9.2366 2.3208 20.5414
BT 482 CTRP2 4.5061 6.5645 4.1995 11.3528
BT147 CTRP2 4.6379 15.0905 0.3017 25.2324
BT 504 CTRP2 4.9826 13.0794 1.6071 20.2564
BT 112 CTRP2 5.0306 8.8491 3.728 11.884
BT 416 CTRP2 5.1473 7.1836 4.6235 7.9645
BT 330 CTRP2 5.264 11.0089 2.8852 14.7913
BT 239 CTRP2 5.2719 7.6281 4.543 7.9793
BT 286 CTRP2 5.2996 9.5462 3.6397 11.6355
BT 131 CTRP2 5.506 15.5541 0.8338 21.7035
BT 139 CTRP2 5.8442 8.3201 4.7357 5.9001
BT164 CTRP2 5.8743 9.6257 4.1101 8.4631
BT 228 CTRP2 5.9854 10.8614 3.5866 10.4279
BT 340 CTRP2 6.4491 14.0339 2.3817 14.3692
BT 145 CTRP2 6.5304 9.7537 4.5775 5.2887
BT 428 CTRP2 6.6065 12.1739 3.4345 9.8961
BT 320 CTRP2 6.6257 11.0045 4.0306 7.4018
BT 422 CTRP2 6.8441 13.2993 3.0599 10.9939
BT 216 CTRP2 6.9446 12.3496 3.607 8.6082
BT 248 CTRP2 7.0658 9.9607 4.8581 3.3252
BT 359 CTRP2 7.1836 13.9212 3.0104 10.6107
BT 328 CTRP2 7.2733 10.8622 4.5667 4.201
BT 231 CTRP2 7.2904 13.0748 3.5058 8.4564
BT 159 CTRP2 7.3366 11.1689 4.4626 4.5285
BT 232 CTRP2 7.363 15.2792 2.4746 12.3876
BT 245 CTRP2 7.4357 14.2303 3.0451 10.0604
BT 444 CTRP2 7.5396 27.5834 -3.5058 28.1319
BT 179 CTRP2 7.5463 11.5866 4.4027 4.4815
BT 498 CTRP2 7.6064 13.539 3.5056 7.9687
BT 187 CTRP2 7.9391 11.0169 4.9032 2.146
BT 224 CTRP2 8.3227 12.7433 4.3493 3.7417
BT 333 CTRP2 10.9507 23.3164 1.0748 12.0265
⏷ Show the Full List of 84 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Daoy GDSC1 0.3669 3.0343 -0.4191 17.5862
H4 GDSC1 0.5689 2.6538 -0.0423 13.8319
KS-1 [Human Krukenberg tumour] GDSC1 0.7911 5.9003 -1.4235 22.5068
D-263MG GDSC1 0.8355 5.957 -1.4125 22.2562
NMC-G1 GDSC1 1.0558 3.6823 -0.0868 12.0898
D-336MG GDSC1 1.0795 5.867 -1.1557 19.6724
SK-MG-1 GDSC1 1.0925 2.3118 0.6249 6.3891
GI-1 GDSC1 1.1689 3.2943 0.2055 9.3719
MOG-G-UVW GDSC1 1.174 2.8253 0.4437 7.4813
D-566MG GDSC1 1.2448 5.1113 -0.6374 15.4916
LNZTA3WT4 GDSC1 1.2524 3.7176 0.0657 10.1503
YKG-1 GDSC1 1.2586 2.7678 0.5456 6.3561
SW1088 GDSC1 1.2696 4.2513 -0.1866 12.0395
D-502MG GDSC1 1.3038 4.7001 -0.3823 13.3957
D-247MG GDSC1 1.3136 3.7244 0.1137 9.5496
MOG-G-CCM GDSC1 1.3198 4.8597 -0.4487 13.8322
CAS-1 GDSC1 1.3297 4.194 -0.1076 11.2109
M059J GDSC1 1.3774 7.2513 -1.5967 21.2151
Onda 10 GDSC1 1.3872 3.5238 0.2749 8.0207
DBTRG-05MG GDSC1 1.4555 2.8968 0.6429 4.8906
SF126 GDSC1 1.6271 4.122 0.1673 8.0495
KNS-42 GDSC1 1.7576 4.0365 0.3085 6.543
GB-1 GDSC1 1.7974 3.9931 0.3589 6.0339
LN-18 GDSC1 1.813 3.3705 0.6723 3.5938
D-542MG GDSC1 1.8245 4.9757 -0.1049 9.5113
KNS-81-FD GDSC1 1.9174 5.5294 -0.3085 10.7468
PFSK-1 GDSC1 1.9837 5.388 -0.1894 9.6543
SF295 GDSC1 2.0073 7.5475 -1.2398 16.8633
Onda 11 GDSC1 2.0337 8.6636 -1.7739 19.9116
KALS-1 GDSC1 2.0559 6.114 -0.4933 11.6648
LN-405 GDSC1 2.2775 7.7343 -1.1269 15.2843
KINGS-1 GDSC1 2.3294 8.7499 -1.5895 17.9243
U-87MG ATCC GDSC1 2.367 5.0048 0.2616 5.2408
LN-229 GDSC1 2.5405 5.1531 0.3015 4.551
GaMG GDSC1 2.5794 9.4389 -1.7422 18.0146
A-172 GDSC1; CTRP2 2.8026 5.0273 2.7233 21.8665
D-392MG GDSC1 2.9057 6.4059 -0.0527 6.2204
AM-38 GDSC1 3.0427 6.6379 -0.0756 6.0743
D-423MG GDSC1 3.2456 13.9194 -3.4543 23.8463
ONS-76 GDSC1 3.4427 5.1399 0.7621 0.6009
D283 Med GDSC1; CTRP2 4.2033 6.7206 3.817 13.6604
Hs 683 GDSC1; CTRP2 4.3273 7.0992 3.8051 13.3573
SW1783 GDSC1; CTRP2 4.6469 6.9945 4.185 11.0139
42-MG-BA GDSC1; CTRP2 4.7862 6.681 4.4569 9.5832
YH-13 GDSC1; CTRP2 4.7963 7.6268 4.0687 11.0762
SF539 GDSC1; CTRP2 4.8137 6.4259 4.5807 9.0364
DK-MG GDSC1; CTRP2 5.0337 8.6398 3.8314 11.4539
M059K CTRP2 5.1558 8.4562 4.0365 10.3268
CCF-STTG1 CTRP2 5.3854 7.8591 4.5427 7.7109
SF268 GDSC1; CTRP2 5.3983 8.1178 4.43 8.1452
Becker GDSC1; CTRP2 5.4318 8.9241 4.0668 9.5745
KG-1-C CTRP2 5.5694 9.4432 3.9346 9.8268
TM-31 CTRP2 5.8758 10.7388 3.5553 10.7744
T98G GDSC1; CTRP2 6.2181 8.5688 4.9239 4.385
SNB-75 GDSC1; CTRP2 6.5082 10.334 4.2728 6.5964
GMS-10 CTRP2 6.53 9.4153 4.7446 4.5949
8-MG-BA GDSC1; CTRP2 6.646 11.0588 4.0192 7.4141
U-251MG GDSC1; CTRP2 6.6925 8.8901 5.1187 2.8037
U-118MG GDSC1; CTRP2 6.7107 12.4261 3.3904 9.8922
GOS-3 CTRP2 6.905 11.4539 4.0191 6.9827
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 1.3315 3.5393 0.2213 8.6414
ETK-1 GDSC1 1.6976 4.4314 0.068 8.5908
TGBC1TKB GDSC1 1.9344 3.6875 0.6024 3.8024
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 -1.8659 3.662 -2.99 43.3204
RL95-2 GDSC1 1.506 4.0786 0.0938 9.0262
AN3-CA GDSC1; CTRP2 2.3692 8.5109 1.1676 28.5942
KLE GDSC1 2.9462 5.2849 0.4743 2.6158
JHUEM-1 CTRP2 3.829 23.0126 -4.35 36.0772
ESS-1 GDSC1; CTRP2 4.8504 7.4736 4.1921 10.4458
JHUEM-7 CTRP2 4.9172 7.4758 4.2591 10.0071
JHUEM-3 CTRP2 5.7185 7.6962 4.9334 5.3395
MFE-296 GDSC1; CTRP2 5.9051 12.0837 2.9079 13.3607
HEC-1-A CTRP2 6.2091 12.2105 3.0975 12.0023
EN GDSC1; CTRP2 7.7576 14.681 3.0572 9.5064
MFE-319 GDSC1; CTRP2 7.848 9.3974 5.5288 0.3506
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-704 GDSC1 0.9422 3.511 -0.1032 12.6728
LB1047-RCC GDSC1 1.1234 2.9853 0.3195 8.6541
LB2241-RCC GDSC1 1.1381 4.4424 -0.394 14.1104
LB996-RCC GDSC1 1.2818 10.1199 -3.1106 28.5934
KTCTL-26A GDSC1 1.3081 4.2825 -0.1699 11.7692
SW13 GDSC1 1.4167 3.8949 0.1136 9.1813
HA7-RCC GDSC1 1.5812 4.0812 0.152 8.3197
CAL-54 GDSC1 1.629 4.2824 0.0892 8.6501
RXF 393L GDSC1 1.7073 4.501 0.041 8.7682
BFTC-909 GDSC1 1.7524 10.557 -2.9419 26.3355
NCC021 GDSC1 1.9891 10.1207 -2.5346 23.837
769-P GDSC1 2.0593 5.1555 -0.0205 8.1613
KTCTL-140 GDSC1 2.1303 5.389 -0.0837 8.4295
BB65-RCC GDSC1 2.1498 7.583 -1.1483 15.8234
NCC010 GDSC1 2.1505 6.0946 -0.414 10.8028
KTCTL-195 GDSC1 2.2792 4.2078 0.5772 3.1777
OS-RC-2 GDSC1 2.4912 11.7271 -2.9412 23.9985
KTCTL-13 GDSC1 2.5004 6.0895 -0.1657 8.0142
TK-10 GDSC1 2.7646 6.9564 -0.4027 9.0097
SW156 GDSC1 2.9454 9.3782 -1.4465 15.2664
SN12C GDSC1 3.0435 11.547 -2.4365 20.1865
KMRC-20 GDSC1 3.3063 10.0939 -1.5407 14.8269
KTCTL-1M GDSC1 3.6508 6.0122 0.5172 1.4556
KMRC-2 CTRP2 4.042 7.1075 3.4987 15.3244
KTCTL-21 GDSC1 4.1311 13.2693 -2.5037 17.6592
TUHR14TKB CTRP2 5.2597 14.0783 1.3561 20.5138
KMRC-3 CTRP2 5.7647 9.6283 4.0143 9.0862
UO-31 GDSC1; CTRP2 5.7975 15.1545 1.282 19.6277
KMRC-1 GDSC1; CTRP2 5.9627 7.8089 5.0932 4.1587
Caki-2 CTRP2 6.2985 8.6948 4.9246 4.2388
786-O GDSC1; CTRP2 6.5734 9.366 4.8012 4.2888
ACHN GDSC1; CTRP2 6.6129 9.0016 5.0086 3.3715
VMRC-RCZ GDSC1; CTRP2 6.6426 8.8577 5.0997 2.954
A-498 GDSC1; CTRP2 6.8582 8.8134 5.2651 1.9977
Caki-1 GDSC1; CTRP2 7.4079 10.4404 4.8521 2.9103
RCC10RGB GDSC1; CTRP2 7.8649 9.5261 5.4871 0.4341
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 53 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 GDSC1; CTRP2 -1.7244 1.9363 -1.7555 51.7182
SW48 GDSC1 0.7741 1.9528 0.483 8.9112
CaR-1 GDSC1 0.7832 20.0993 -8.5194 40.4403
SK-CO-1 GDSC1 0.9035 2.8309 0.1956 10.5222
HCT 116 GDSC1 1.0945 2.2857 0.6394 6.2671
KM12 GDSC1 1.2286 8.7525 -2.4714 26.2015
COLO205 GDSC1 1.2731 2.7181 0.5827 6.0093
LoVo GDSC1 1.3568 4.1913 -0.0838 10.9291
SNU-81 GDSC1 1.3578 2.9356 0.5448 5.9996
SNU-407 GDSC1 1.4425 3.1881 0.4874 6.1578
CL-11 GDSC1 1.4674 4.8859 -0.3403 12.4892
HCC2998 GDSC1 1.5038 3.4951 0.3829 6.7716
SNU-C2B GDSC1 1.5305 6.8692 -1.2798 18.7576
MDST8 GDSC1 1.5628 3.9297 0.2129 7.9057
HT115 GDSC1 1.5909 3.6625 0.3676 6.6053
LS411N GDSC1 1.6035 18.3564 -6.9618 36.6024
GP5d GDSC1 1.6774 3.8003 0.3651 6.3509
HT-29 GDSC1 1.859 3.8041 0.4949 4.8144
SNU-C5 GDSC1 1.8787 3.85 0.4864 4.8243
LS513 GDSC1 1.8995 3.7506 0.5487 4.296
SW620 GDSC1 1.9301 3.959 0.4694 4.8132
LS180 GDSC1 2.08 6.2713 -0.5529 12.0169
COLO 320HSR GDSC1 2.1593 6.2585 -0.4881 11.3102
NCI-H508 GDSC1 2.2191 4.3458 0.4763 4.0328
RKO GDSC1 2.4137 7.015 -0.674 11.8619
DiFi GDSC1 2.4608 5.4232 0.125 6.0048
HT-55 GDSC1 2.4671 4.5305 0.5416 3.0373
SW1463 GDSC1 2.5156 4.8738 0.4147 3.8113
SNU-1040 GDSC1 2.7425 4.6703 0.6309 1.9817
SW626 GDSC1 2.8701 5.8976 0.1593 4.8317
CW-2 GDSC1 3.0603 5.3705 0.4971 2.3004
CCK-81 GDSC1 3.1391 5.7896 0.359 3.0151
SNU-61 GDSC1 3.1799 5.0675 0.6784 1.1689
SNU-C1 GDSC1; CTRP2 3.1947 6.2944 2.8627 20.1542
SW1116 GDSC1 3.3502 5.1932 0.704 0.8948
SW837 GDSC1 3.3767 5.5545 0.5745 1.4674
LS123 GDSC1 3.4454 15.0875 -3.8812 24.8167
GP2d CTRP2 3.7938 7.1793 3.2064 17.1333
T84 GDSC1; CTRP2 4.1332 7.2551 3.5374 14.923
C2BBe1 GDSC1; CTRP2 4.5783 7.4304 3.9311 12.1892
SW948 GDSC1; CTRP2 4.5823 6.7964 4.195 11.154
COLO 320 CTRP2 4.585 7.8867 3.7379 12.9355
COLO 678 GDSC1; CTRP2 5.3206 9.2282 3.8153 10.8633
LS1034 GDSC1; CTRP2 5.9187 7.6415 5.1388 4.0563
HCT 15 GDSC1; CTRP2 6.031 7.4451 5.3328 3.0169
SNU-1033 CTRP2 6.2634 9.559 4.4661 6.2231
SW1417 GDSC1; CTRP2 6.3945 9.648 4.5254 5.7403
HCC-56 CTRP2 6.542 8.7153 5.0975 3.1163
HCT 8 CTRP2 6.9537 9.175 5.1564 2.2989
NCI-H747 GDSC1; CTRP2 7.1816 9.4121 5.1874 1.9093
SNU-C4 CTRP2 7.2634 8.2021 5.7361 0.1595
RCM-1 [Human ESC] GDSC1; CTRP2 7.3456 8.6841 5.5872 0.4531
SNU-503 CTRP2 7.5062 11.5745 4.3822 4.6161
⏷ Show the Full List of 53 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.5097 5.7367 0.5625 1.3841
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC1 -0.1005 3.6894 -1.1864 25.1472
JHH-7 GDSC1 0.4509 4.2009 -0.8952 20.5939
HLE GDSC1 0.5026 7.1481 -2.2993 28.3069
Huh-7 GDSC1 0.6976 2.1611 0.3123 10.5558
SNU-398 GDSC1 2.1022 4.3996 0.3748 5.069
Hep-G2/C3A GDSC1 2.225 3.8449 0.7099 2.3736
SNU-475 CTRP2 4.083 6.2269 3.8514 13.8842
SNU-423 GDSC1; CTRP2 4.8791 10.6551 2.7081 16.3573
SNU-387 GDSC1; CTRP2 5.2853 11.2658 2.7769 15.1773
JHH-1 GDSC1; CTRP2 5.6397 7.1817 5.1112 4.7805
HLF CTRP2 5.7832 9.6717 4.0087 9.0718
JHH-5 CTRP2 5.8623 9.4009 4.2121 8.0594
HuH-1 GDSC1; CTRP2 5.9783 9.8948 4.0639 8.4506
SNU-449 GDSC1; CTRP2 6.0467 8.6338 4.7516 5.4299
PLC/PRF/5 CTRP2 6.0578 7.0097 5.5729 1.9563
JHH-2 GDSC1; CTRP2 6.2541 10.1698 4.1537 7.5494
JHH-4 GDSC1; CTRP2 6.2979 12.5203 3.0152 12.1662
JHH-6 GDSC1; CTRP2 6.6744 17.4727 0.8464 19.3323
SK-HEP-1 GDSC1; CTRP2 7.2262 10.0876 4.9023 2.9412
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 192 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1581 GDSC1 -3.0367 3.0578 -4.0005 52.7658
EPLC-272H GDSC1 -1.2761 9.9329 -5.3027 43.4964
NCI-H2228 GDSC1 -0.9583 4.2833 -2.319 35.609
NCI-H2795 GDSC1 -0.611 1.7509 -0.9185 26.1735
LK-2 GDSC1 -0.5032 5.7994 -2.5742 34.1044
NCI-H2810 GDSC1 0.0441 2.9177 -0.69 21.1009
NCI-H2227 GDSC1 0.1559 2.9218 -0.5785 19.7566
EMC-BAC-2 GDSC1 0.178 5.4844 -1.7755 27.1969
HCC78 GDSC1 0.1884 11.9399 -4.9589 37.4537
NCI-H446 GDSC1 0.1891 4.5575 -1.3154 24.5277
NCI-H847 GDSC1 0.2056 1.786 -0.0485 15.6812
NCI-H1048 GDSC1 0.3216 2.3289 -0.1464 15.7946
NCI-H1688 GDSC1 0.4054 5.9968 -1.8173 26.3821
SBC-3 GDSC1 0.4616 2.9329 -0.2784 16.1019
LC-2/ad GDSC1 0.6081 5.9738 -1.6227 24.4377
A-427 GDSC1 0.7299 5.109 -1.0851 20.644
PC-14 GDSC1 0.8074 3.1266 -0.0384 12.7387
RERF-LC-KJ GDSC1 0.8222 1.8519 0.5767 7.9801
NCI-H2009 GDSC1 0.8515 4.1981 -0.5249 16.2279
NCI-H69 GDSC1 0.8754 3.7196 -0.2668 14.1991
NCI-H358 GDSC1 0.8864 3.8215 -0.3071 14.4588
UMC-11 GDSC1 0.9117 3.2927 -0.0232 12.1822
IST-SL1 GDSC1 0.944 6.5683 -1.6225 23.0391
NCI-H3122 GDSC1 0.9588 3.2672 0.0322 11.5588
Lu-135 GDSC1 0.9675 3.005 0.1694 10.4574
NCI-H2122 GDSC1 0.9969 4.6656 -0.628 16.3879
NCI-H1155 GDSC1 1.0225 2.669 0.385 8.5496
Lu-99A GDSC1 1.0349 4.3162 -0.4206 14.7125
NCI-H1648 GDSC1 1.036 3.3162 0.0775 10.8936
HCC44 GDSC1 1.0415 3.6 -0.0585 11.928
SBC-1 GDSC1 1.0575 4.3832 -0.4343 14.7253
NCI-H2803 GDSC1 1.0796 4.9267 -0.6862 16.478
A-549 GDSC1 1.0817 4.7359 -0.5891 15.7703
NCI-H524 GDSC1 1.1013 3.0513 0.2671 9.1524
NCI-H441 GDSC1 1.1571 6.2731 -1.2924 20.2339
NCI-H2818 GDSC1 1.1737 4.0979 -0.1915 12.4381
HCC15 GDSC1 1.1797 3.9218 -0.0984 11.6986
NCI-H211 GDSC1 1.206 3.0381 0.3654 7.9737
NCI-H3255 GDSC1 1.2078 5.9048 -1.0653 18.5853
NCI-H1436 GDSC1 1.2117 2.9348 0.4219 7.5071
LB647-SCLC GDSC1 1.243 3.1102 0.3612 7.8662
NCI-H1792 GDSC1 1.2726 3.8213 0.0309 10.347
NCI-H2369 GDSC1 1.2939 4.631 -0.356 13.2357
NCI-H1355 GDSC1 1.3071 4.2106 -0.1348 11.5032
NCI-H460 GDSC1 1.3342 3.2713 0.3575 7.5607
NCI-H1573 GDSC1 1.3592 4.2696 -0.121 11.2071
NCI-H2135 GDSC1 1.3631 3.4626 0.2857 8.0221
CAL-12T GDSC1 1.3728 3.1207 0.4646 6.5793
DV-90 CTRP2 1.3812 6.8117 0.7268 33.1421
RERF-LC-Sq1 GDSC1 1.3827 4.6087 -0.2711 12.2696
NCI-H2030 GDSC1 1.3852 4.6971 -0.3132 12.579
NCI-H209 GDSC1 1.4045 4.208 -0.0529 10.5194
LCLC-103H GDSC1 1.422 5.7734 -0.821 16.1306
SK-LU-1 GDSC1 1.424 4.3405 -0.1031 10.8376
LXF 289 GDSC1 1.4275 4.8965 -0.3781 12.9144
NCI-H1781 GDSC1 1.4464 17.87 -6.8486 36.8352
NCI-H2731 GDSC1 1.4678 4.3943 -0.0944 10.6164
COR-L32 GDSC1 1.4693 11.2115 -3.5006 29.3148
NCI-H1299 GDSC1 1.4936 3.9633 0.1415 8.6968
BEN GDSC1 1.5369 4.8619 -0.2722 11.7324
EMC-BAC-1 GDSC1 1.5433 3.7321 0.296 7.3211
NCI-H596 GDSC1 1.5566 5.7817 -0.7155 14.9089
SBC-5 GDSC1 1.5596 3.0703 0.6371 4.599
NCI-H2595 GDSC1 1.5913 3.9863 0.2071 7.8573
CPC-N GDSC1 1.603 4.259 0.0805 8.8028
NCI-H2461 GDSC1 1.6038 3.6647 0.3763 6.4958
NCI-H1755 GDSC1 1.6309 4.5306 -0.0327 9.5858
Calu-6 GDSC1 1.6795 4.7992 -0.1284 10.1583
NCI-H292 GDSC1 1.6891 6.8629 -1.1488 17.3658
LCLC-97TM1 GDSC1 1.6971 4.2995 0.1331 8.0899
NCI-H720 GDSC1 1.7069 6.3949 -0.9013 15.6699
NCI-H1693 GDSC1 1.7131 4.045 0.2711 6.9694
NCI-H82 GDSC1 1.7463 6.0451 -0.696 14.115
NCI-H1876 GDSC1 1.7651 5.2068 -0.2646 10.9077
Lu-165 GDSC1 1.7805 4.2666 0.2121 7.2178
NCI-H2023 GDSC1 1.8085 3.635 0.5415 4.6
NCI-H650 GDSC1 1.8253 3.6862 0.5285 4.6525
SHP-77 GDSC1 1.8362 5.9589 -0.5832 13.013
NCI-H226 GDSC1 1.8436 5.8022 -0.4997 12.387
EBC-1 GDSC1 1.8538 5.5665 -0.3751 11.4418
NCI-H290 GDSC1 1.8548 4.228 0.2855 6.4291
NCI-H196 GDSC1 1.8559 3.9864 0.4042 5.516
NCI-H2373 GDSC1 1.8584 4.681 0.0658 8.1043
NCI-H1341 GDSC1; CTRP2 1.8921 6.5016 1.3802 29.3935
LOU-NH91 GDSC1 1.8993 4.1097 0.375 5.6156
HCC366 GDSC1 1.9116 7.3588 -1.2203 17.0587
COR-L321 GDSC1 1.922 6.2303 -0.6518 13.2205
NCI-H2172 GDSC1 1.9413 3.5047 0.6934 3.1113
NCI-H2722 GDSC1 1.9554 5.1589 -0.0977 9.0513
SW1271 GDSC1 1.9613 4.2365 0.357 5.5797
NCI-H513 GDSC1 1.9865 4.2113 0.3866 5.2869
NCI-H2066 GDSC1 1.9942 5.5053 -0.2394 9.9948
Ms-1 GDSC1 1.9984 5.3591 -0.1644 9.4224
SW1573 GDSC1 2.0017 7.1039 -1.024 15.4984
NCI-H1770 GDSC1 2.006 8.3057 -1.6175 19.1277
NCI-H2085 GDSC1 2.0069 4.4572 0.2819 6.0228
NCI-H2804 GDSC1 2.0084 6.2328 -0.5875 12.4882
NCI-H1437 GDSC1 2.043 4.1495 0.4545 4.6265
NCI-H187 GDSC1 2.0698 5.0738 0.0269 7.774
NCI-H835 GDSC1 2.0941 8.1017 -1.4479 17.8489
NCI-H2869 GDSC1 2.1069 6.549 -0.6697 12.7582
NCI-H1975 GDSC1 2.111 13.596 -4.1705 29.3916
DMS 79 GDSC1 2.1494 6.728 -0.7263 13.0195
COR-L23 GDSC1 2.1602 4.7698 0.2367 5.9483
NCI-H661 GDSC1 2.1877 4.9435 0.172 6.3583
NCI-H1836 GDSC1 2.2135 7.8538 -1.234 16.1614
NCI-H526 GDSC1 2.2244 4.5258 0.3952 4.6109
NCI-H2347 GDSC1 2.3214 4.8134 0.3223 4.9088
NCI-H727 GDSC1 2.3571 4.5001 0.4902 3.6216
NCI-H2291 GDSC1 2.3661 6.9968 -0.6993 12.176
NCI-H2087 GDSC1 2.3938 7.0782 -0.7192 12.2307
NCI-H1993 GDSC1 2.4237 5.9673 -0.1591 8.1703
IST-SL2 GDSC1 2.4394 4.8427 0.3827 4.2008
NCI-H345 GDSC1 2.4398 3.471 0.9754 0.5185
LC-1/sq GDSC1 2.4848 14.4546 -4.3022 28.7029
Lu-134-A GDSC1 2.5094 5.9831 -0.1088 7.5793
NCI-H2141 GDSC1; CTRP2 2.5488 4.5981 0.5581 2.1549
NCI-H2591 GDSC1 2.5808 12.5715 -3.2913 25.099
Calu-3 GDSC1 2.6852 6.0541 -0.0274 6.5564
NCI-H1435 GDSC1 2.7206 5.4274 0.2845 4.2829
COR-L279 GDSC1; CTRP2 2.759 14.0054 -0.9218 33.0197
NCI-H1650 GDSC1 2.7832 9.3714 -1.5595 16.3837
Lu-139 GDSC1 2.7916 4.7501 0.6223 1.9592
NCI-H2405 GDSC1 2.8084 5.3007 0.3922 3.3822
NCI-H146 GDSC1 2.8158 6.752 -0.2719 7.9661
NCI-H520 GDSC1; CTRP2 2.8447 9.9763 1.0352 27.6127
NCI-H2444 GDSC1 2.8744 4.1603 0.896 0.498
NCI-H1304 GDSC1 2.8772 4.3582 0.822 0.7993
NCI-H1666 GDSC1 2.9686 5.6068 0.3463 3.389
NCI-H1838 GDSC1 3.0042 6.2279 0.0887 5.0349
COR-L88 GDSC1 3.1401 8.3954 -0.8385 10.9804
NCI-H322M GDSC1 3.2306 6.0542 0.2933 3.2717
HCC827 GDSC1 3.3522 5.2185 0.6951 0.9305
VMRC-LCD GDSC1; CTRP2 3.3953 6.6339 2.9732 19.1527
NCI-H1385 CTRP2 3.5168 5.6884 3.3743 17.331
HARA [Human squamous cell lung carcinoma] GDSC1 3.5965 13.3664 -2.926 20.8519
ABC-1 GDSC1 3.8861 6.4479 0.4509 1.5308
DMS 53 GDSC1; CTRP2 3.999 21.0831 -3.2409 34.2098
PaCa-3 GDSC1 4.1169 6.4362 0.5535 0.9022
NCI-H2110 GDSC1; CTRP2 4.3921 8.7446 3.1537 15.752
NCI-H2171 CTRP2 4.4367 6.2672 4.2243 11.4631
COLO 668 GDSC1; CTRP2 4.4442 8.6826 3.2342 15.3011
NCI-H522 GDSC1; CTRP2 4.5524 8.9678 3.2085 15.1356
DMS 454 CTRP2 4.6655 7.6603 3.9206 12.0023
DMS 114 GDSC1; CTRP2 4.7304 10.144 2.8179 16.2679
NCI-H1563 GDSC1; CTRP2 4.8452 8.3773 3.7729 12.1442
NCI-H1703 GDSC1; CTRP2 4.8504 8.3453 3.7929 12.0503
NCI-H2081 GDSC1; CTRP2 4.9573 9.1941 3.4919 13.0202
LUDLU-1 CTRP2 4.9937 8.9017 3.6675 12.2181
RERF-LC-MS GDSC1; CTRP2 5.0433 7.867 4.2065 9.9026
NCI-H810 GDSC1; CTRP2 5.1258 10.3712 3.0748 14.333
NCI-H23 GDSC1; CTRP2 5.3937 8.7233 4.1304 9.3953
SK-MES-1 GDSC1; CTRP2 5.4378 8.2688 4.3935 8.2063
NCI-H841 GDSC1; CTRP2 5.4868 7.3408 4.8882 6.055
NCI-H1568 GDSC1; CTRP2 5.5091 9.7508 3.7281 10.814
IA-LM GDSC1; CTRP2 5.5736 7.97 4.6657 6.7726
HCC4006 CTRP2 5.5859 9.916 3.7143 10.7084
NCI-H838 GDSC1; CTRP2 5.645 8.6224 4.4091 7.6856
LK2 CTRP2 5.7775 7.2592 5.2024 4.0907
NCI-H647 GDSC1; CTRP2 5.8207 8.6933 4.5292 6.8143
NCI-H1092 GDSC1; CTRP2 5.8567 10.4198 3.6983 10.2188
HOP-92 GDSC1; CTRP2 5.8751 10.0271 3.9103 9.2977
NCI-H1623 GDSC1; CTRP2 5.9154 10.1769 3.8697 9.3869
NCI-H1339 CTRP2 5.9503 8.4339 4.7704 5.5395
NCI-H1944 GDSC1; CTRP2 5.9842 11.5185 3.2571 11.7885
HCC1438 CTRP2 6.0785 9.4297 4.3801 6.9297
NCI-H1694 GDSC1; CTRP2 6.0817 11.1332 3.5311 10.4705
COR-L95 GDSC1; CTRP2 6.1218 8.8811 4.69 5.5451
RERF-LC-Ad2 CTRP2 6.2872 12.4432 3.045 12.0663
Lu-65 GDSC1; CTRP2 6.3057 12.0788 3.2421 11.2319
EKVX GDSC1; CTRP2 6.3157 12.4087 3.0854 11.8495
NCI-H1105 GDSC1; CTRP2 6.3543 8.5141 5.0573 3.5881
NCI-H1651 GDSC1; CTRP2 6.3687 8.4562 5.097 3.3986
NCI-H1915 GDSC1; CTRP2 6.3811 9.4583 4.6093 5.4126
ChaGo-K-1 GDSC1; CTRP2 6.4417 11.6414 3.5697 9.6367
NCI-H2029 GDSC1; CTRP2 6.4803 8.8394 4.9914 3.6527
DMS 273 GDSC1; CTRP2 6.4803 12.4573 3.1936 11.1059
HOP-62 GDSC1; CTRP2 6.5301 10.9757 3.971 7.8155
COR-L105 GDSC1; CTRP2 6.5506 10.3474 4.2988 6.4152
T3M-10 CTRP2 6.7049 8.2902 5.4127 1.6184
NCI-H1869 GDSC1; CTRP2 6.7393 11.2078 4.0165 7.2672
NCI-H2170 GDSC1; CTRP2 6.7761 9.6771 4.7958 3.9929
NCI-H2342 GDSC1; CTRP2 6.8174 10.0042 4.6659 4.4618
NCI-H2196 CTRP2 7.0916 12.5108 3.637 8.2443
KNS-62 GDSC1; CTRP2 7.3063 10.5674 4.7283 3.5177
NCI-H1395 CTRP2 7.3075 9.4255 5.2543 1.5336
NCI-H322 CTRP2 7.4454 10.6876 4.7606 3.2154
LC-1/sq-SF CTRP2 7.5703 11.7634 4.3347 4.7175
NCI-H1793 GDSC1; CTRP2 7.5902 12.4792 4.0063 5.9941
HCC2935 CTRP2 8.3359 9.8953 5.5385 0.1837
Calu-1 CTRP2 9.3258 17.7445 2.6508 8.82
Hs 888.Lu CTRP2 5.8689 9.4907 4.1729 8.2103
⏷ Show the Full List of 192 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 1.7672 4.8323 -0.0774 9.4843
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 4.1661 7.0381 3.6579 14.3694
SK-OV-3 GDSC1 0.9599 2.5522 0.384 8.8213
JHOS-4 GDSC1 1.206 3.103 0.333 8.2281
DOV13 GDSC1 1.2805 4.407 -0.2552 12.5232
OVCAR-4 GDSC1 1.449 3.641 0.2665 7.8708
OVK18 GDSC1 1.5389 4.4797 -0.08 10.2597
TYK-nu GDSC1 1.6626 3.7752 0.3664 6.3868
OVTOKO GDSC1 1.8591 11.1337 -3.1438 26.7653
Kuramochi GDSC1 2.0177 4.1526 0.436 4.8311
OVISE GDSC1 2.127 4.1186 0.5241 3.9035
RMG-I GDSC1 2.2476 6.1333 -0.3627 10.1439
FU-OV-1 GDSC1 2.3936 5.8876 -0.1413 8.1216
OVCAR-3 GDSC1 2.6296 5.1071 0.3761 3.8406
Caov-4 GDSC1 2.6348 5.0488 0.4055 3.6291
OVKATE GDSC1 2.8281 5.2313 0.4338 3.0739
ES-2 GDSC1 2.9057 4.952 0.595 1.9517
COV434 CTRP2 3.4781 8.7359 2.2305 21.7006
A2780 GDSC1 3.8939 6.0269 0.6153 0.8286
OVCAR-8 GDSC1 4.4028 6.0558 0.7942 0.1553
TOV-112D GDSC1; CTRP2 4.6078 8.1187 3.6563 13.2033
JHOM-1 CTRP2 4.9678 10.4188 2.906 15.3683
COV362 CTRP2 5.3267 9.0121 3.9269 10.388
OV-90 GDSC1; CTRP2 5.587 7.3559 4.9771 5.4546
OV7 CTRP2 5.814 10.744 3.4999 11.1281
TOV-21G GDSC1; CTRP2 6.1956 8.2637 5.0581 3.8631
OVCAR-5 GDSC1; CTRP2 6.2209 9.4536 4.4845 6.2236
EFO-27 GDSC1; CTRP2 6.3303 7.8616 5.3616 2.3631
OV56 GDSC1; CTRP2 6.4528 8.1196 5.3243 2.3236
OAW42 GDSC1; CTRP2 6.5059 8.316 5.2664 2.4795
OC 314 GDSC1; CTRP2 6.5447 8.8997 5.0092 3.4755
COV644 CTRP2 6.571 8.6843 5.1334 2.9246
EFO-21 GDSC1; CTRP2 6.7107 9.3894 4.8894 3.7099
OAW28 GDSC1; CTRP2 7.4573 13.6253 3.3572 8.789
JHOS-2 GDSC1; CTRP2 7.8927 14.227 3.3722 8.0708
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 4.5624 9.1352 3.1394 15.3876
P-STS CTRP2 5.274 7.3173 4.6902 7.3775
H-STS CTRP2 6.0785 6.8277 5.6808 1.4638
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 5.8286 8.9722 4.397 7.3526
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 6.8466 11.7357 3.8366 7.8302
Aska-SS CTRP2 9.1627 20.1437 1.394 13.4122
STS-0421 GDSC1 -3.6555 2.0643 -4.3296 57.8384
Rh41 GDSC1 0.4317 2.8737 -0.2804 16.2565
Rh18 GDSC1 1.0427 3.791 -0.1523 12.6466
VA-ES-BJ GDSC1 1.0545 3.9488 -0.2206 13.1232
SW872 GDSC1 1.266 3.4154 0.2282 8.8271
Rh30 GDSC1 1.3632 4.0066 0.0138 10.1492
EW-8 GDSC1 1.4328 2.9987 0.574 5.5089
SW684 GDSC1 1.5963 3.3632 0.5199 5.3982
Hs 633.T GDSC1 1.701 3.3474 0.6051 4.4196
MFH-ino GDSC1 1.9465 3.8785 0.5192 4.3934
RKN GDSC1 2.6724 6.9172 -0.446 9.5538
G-401 GDSC1; CTRP2 3.1973 6.2459 2.88 20.0837
TTC-709 CTRP2 4.0361 8.8765 2.7367 18.2973
G-402 GDSC1; CTRP2 4.5111 6.9069 4.0762 11.807
A-204 GDSC1; CTRP2 4.5297 8.3931 3.4526 14.2146
Hs 729.T CTRP2 4.5315 8.8312 3.2518 15.0134
SW982 GDSC1; CTRP2 5.5252 9.8088 3.7137 10.8393
GCT GDSC1; CTRP2 5.6564 8.8207 4.321 8.029
TE 617.T CTRP2 5.6905 7.2406 5.1307 4.5829
RD GDSC1; CTRP2 5.9403 8.7042 4.6268 6.1627
MES-SA GDSC1; CTRP2 6.0304 7.337 5.3864 2.7928
KYM-1 GDSC1; CTRP2 6.0525 10.8191 3.6637 9.977
BT-16 CTRP2 6.4172 7.7636 5.4722 1.7736
HT-1080 GDSC1; CTRP2 6.5193 9.4235 4.7325 4.6628
Tm87-16 CTRP2 6.5968 11.6508 3.6872 8.8743
BT-12 CTRP2 7.0957 8.0129 5.7386 0.2155
SK-LMS-1 GDSC1; CTRP2 7.243 10.4159 4.7587 3.4813
TE 441.T CTRP2 7.2712 8.7483 5.5263 0.6694
SK-UT-1 GDSC1; CTRP2 7.5461 11.1368 4.6144 3.6546
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 -0.5042 2.2463 -0.9822 25.985
MPP 89 GDSC1 1.303 5.407 -0.7364 15.979
NCI-H28 GDSC1 1.3461 5.5312 -0.7626 16.0025
NCI-H2452 GDSC1 1.4231 8.0454 -1.9559 23.0076
IST-Mes1 GDSC1; CTRP2 3.9115 6.1913 3.675 15.042
JL-1 CTRP2 5.7799 10.5078 3.5886 10.8297
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1; CTRP2 2.7172 4.1355 2.7098 22.1909
22Rv1 GDSC1 2.744 5.451 0.2876 4.2133
PC-3 GDSC1 3.0935 5.8402 0.3125 3.385
LNCaP clone FGC GDSC1; CTRP2 5.47 7.9321 4.5875 7.3307
DU145 GDSC1; CTRP2 6.2741 11.68 3.4156 10.581
PaCa-3 CTRP2 6.5565 8.505 5.2103 2.6324
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; CTRP2 7.4326 12.3797 3.9458 6.4645
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.6559 9.1238 -2.3043 23.9022
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1 -3.5968 -2.0187 -3.5983 61.3716
KATO III GDSC1 -3.087 2.2245 -3.7633 53.4669
ECC10 GDSC1 -0.8973 1.4333 -1.1313 29.2263
SNU-16 GDSC1; CTRP2 -0.4288 3.1977 -0.4929 43.279
Fu97 GDSC1 -0.3021 3.1713 -1.1557 25.9996
AGS GDSC1 0.703 4.4094 -0.7637 18.5728
SNU-5 GDSC1 1.026 5.1799 -0.8589 17.9038
TMK-1 GDSC1 1.1056 2.6248 0.4824 7.4484
MKN45 GDSC1 1.4169 3.8628 0.1297 9.0542
23132/87 GDSC1 1.4421 4.7133 -0.2747 12.0841
NUGC-3 GDSC1 1.5506 4.7655 -0.2132 11.2378
SCH GDSC1 1.7395 5.8169 -0.5877 13.3678
RERF-GC-1B GDSC1 2.0066 6.1729 -0.5593 12.2924
SK-GT-2 GDSC1 2.0576 4.46 0.3156 5.6302
OCUM-1 GDSC1 2.2909 5.6413 -0.0932 8.0486
MKN1 GDSC1 2.3022 5.5412 -0.0372 7.6046
TGBC11TKB GDSC1 2.3864 4.6008 0.4618 3.7581
RF-48 GDSC1 2.4703 5.5765 0.0587 6.4628
NUGC-4 GDSC1 2.6764 4.9088 0.4918 2.9709
MKN28 GDSC1 2.6916 5.7212 0.1319 5.411
NCI-N87 GDSC1 2.9309 5.361 0.4332 2.8982
NCC-StC-K140 CTRP2 3.5235 6.2079 3.2469 17.7679
HGC-27 GDSC1; CTRP2 4.1247 6.5996 3.7753 14.043
SNU-1 GDSC1; CTRP2 4.9009 7.9856 4.0104 11.0468
HuG1-N CTRP2 6.1554 12.3877 2.9647 12.641
SNU-216 CTRP2 6.186 8.5283 4.9184 4.4665
LMSU CTRP2 6.227 10.4757 3.979 8.3306
KE-39 CTRP2 6.5436 12.0925 3.4256 10.0448
SH-10-TC CTRP2 6.6585 10.4538 4.3282 6.1106
IM95 GDSC1; CTRP2 6.7971 9.205 5.0388 2.9757
MKN7 GDSC1; CTRP2 7.258 11.8415 4.0844 6.1644
Hs 746.T GDSC1; CTRP2 7.9772 9.6465 5.4885 0.3828
SNU-601 CTRP2 8.1815 12.1546 4.5331 3.2216
MKN74 CTRP2 9.5165 18.8314 2.2613 9.9572
SNG-M GDSC1 0.8733 2.8361 0.1647 10.8902
SNU-685 CTRP2 6.4093 11.0534 3.8371 8.5875
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 1.273 3.542 0.1708 9.2512
K5 GDSC1 1.2883 3.4108 0.2493 8.5789
WRO GDSC1 1.3657 3.8578 0.0903 9.5442
CGTH-W-1 GDSC1 1.5145 3.9094 0.185 8.2859
B-CPAP GDSC1 1.5347 4.8571 -0.2716 11.735
KMH-2 GDSC1 1.8125 4.2888 0.2248 7.0222
CAL-62 GDSC1 1.9061 3.7188 0.5684 4.13
8505C GDSC1 1.9158 4.0156 0.4322 5.1344
BHT-101 GDSC1 2.0193 5.9384 -0.434 11.3493
ML-1 [Human leukemia] GDSC1 2.0211 6.1047 -0.5147 11.9272
ASH-3 GDSC1 2.3255 7.9331 -1.1891 15.5294
HTC-C3 GDSC1 2.3994 5.9461 -0.1655 8.2826
8305C GDSC1 2.8551 13.1838 -3.3847 24.6601
TT GDSC1 3.2955 15.6871 -4.2895 26.4989
SW579 CTRP2 4.5903 7.4261 3.9454 12.1008
FTC-238 CTRP2 6.0688 8.9061 4.6338 5.882
TT2609-C02 GDSC1; CTRP2 6.4491 9.1447 4.8172 4.4279
FTC-133 GDSC1; CTRP2 6.573 9.4698 4.7498 4.5027
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-3 GDSC1 -0.5605 6.5355 -2.982 35.7804
BB49-HNC GDSC1 0.0404 3.2425 -0.8403 22.1626
SKN-3 GDSC1 0.0492 2.3474 -0.4374 19.2801
SAT [Human HNSCC] GDSC1 0.3762 5.6366 -1.6666 25.7022
HSC-4 GDSC1 0.5229 4.5527 -0.9996 20.9769
Detroit 562 GDSC1 0.9848 9.6219 -3.1122 29.6709
JHU-029 GDSC1 1.1815 3.4218 0.1528 9.7366
SCC-25 GDSC1 1.2446 4.097 -0.1306 11.7025
PCI-38 GDSC1 1.2547 2.927 0.4627 7.0235
BB30-HNC GDSC1 1.3264 3.4569 0.2582 8.37
BICR 10 GDSC1 1.3285 3.9495 0.0136 10.2761
HO-1-N-1 GDSC1 1.3707 3.2523 0.3971 7.118
HO-1-u-1 GDSC1 1.4116 3.8585 0.1276 9.09
KON GDSC1 1.4462 4.1763 -0.0031 9.9861
BICR 78 GDSC1 1.5277 10.6243 -3.1589 27.9205
PCI-04B GDSC1 1.7037 4.5429 0.0175 8.9612
LB771-HNC GDSC1 1.7415 4.9748 -0.1677 10.2539
JHU-011 GDSC1 1.7473 9.5699 -2.4531 24.2773
BHY GDSC1 1.7787 3.6572 0.5096 4.9291
PCI-30 GDSC1 1.7958 4.0086 0.3501 6.1066
PCI-15A GDSC1 1.8396 3.9788 0.3963 5.6234
DOK GDSC1 1.8532 6.0038 -0.5923 13.0228
KOSC-2 GDSC1 1.8539 5.5825 -0.3829 11.4991
OSC-19 GDSC1 1.8549 7.1961 -1.1837 17.018
JHU-022 GDSC1 1.9608 4.3571 0.2982 6.0281
Ca9-22 GDSC1 1.9852 4.5653 0.2143 6.5971
OSC-20 GDSC1 2.0254 6.0578 -0.4883 11.7238
NCI-H3118 GDSC1 2.0476 4.4954 0.2917 5.8376
SCC-15 GDSC1 2.212 10.2748 -2.4361 22.6701
UPCI-SCC-090 GDSC1 2.2207 8.6031 -1.5994 18.3252
PCI-06A GDSC1 2.4418 8.0256 -1.1486 14.9182
SAS GDSC1 2.4693 5.3058 0.1858 5.5441
PE/CA-PJ49 CTRP2 5.1142 7.9129 4.2548 9.5336
PE/CA-PJ34 (clone C12) CTRP2 5.3663 9.7003 3.6246 11.5512
BICR 6 CTRP2 5.4333 8.9376 4.0615 9.593
CAL-27 GDSC1; CTRP2 5.5559 8.4134 4.4317 7.7845
BICR 16 CTRP2 5.7245 9.2894 4.1482 8.6091
CAL-33 GDSC1; CTRP2 6.0282 8.1641 4.971 4.543
BICR 31 CTRP2 6.2401 13.5734 2.4417 14.5373
PE/CA-PJ15 GDSC1; CTRP2 6.2776 9.5156 4.4991 6.0588
SCC-4 GDSC1; CTRP2 6.3176 8.5258 5.0234 3.7924
HSC-2 GDSC1; CTRP2 6.4122 8.9565 4.8824 4.2188
BICR 18 CTRP2 6.5656 11.1695 3.9022 8.0391
BICR 56 CTRP2 6.708 8.758 5.1928 2.4831
FaDu GDSC1; CTRP2 6.7714 10.8849 4.2001 6.4543
SCC-9 GDSC1; CTRP2 7.2553 13.8357 3.1061 10.1127
PE/CA-PJ41 (clone D2) CTRP2 7.5388 16.4215 2.0425 13.6976
BICR 22 GDSC1; CTRP2 8.3691 9.7237 5.61 0.0936
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 GDSC1 -1.7304 6.8877 -4.2858 44.4548
RT-4 GDSC1 0.981 6.7467 -1.6796 23.2108
UM-UC-1 CTRP2 0.9907 6.2133 0.4822 35.2145
TCCSUP GDSC1 1.0019 7.5175 -2.0464 25.0652
CAL-29 GDSC1 1.3791 5.6578 -0.7986 16.1322
SW1710 GDSC1 1.4363 4.3446 -0.0952 10.7329
SW780 GDSC1 1.5161 15.6659 -5.6889 34.7112
639V GDSC1 1.5374 13.6344 -4.6557 32.4092
HT-1376 GDSC1 1.7748 8.2065 -1.7507 20.658
5637 GDSC1 2.0318 4.8267 0.1201 7.1786
UM-UC-3 GDSC1 2.269 4.2152 0.5677 3.2667
KU-19-19 GDSC1 2.758 19.3017 -6.501 33.0457
J82 GDSC1; CTRP2 5.3377 8.2684 4.2998 8.8217
BC-3C CTRP2 5.4208 8.4263 4.3008 8.6284
647V GDSC1; CTRP2 5.9775 8.6211 4.6999 5.782
U-BLC1 CTRP2 5.9976 7.9407 5.057 4.2418
KMBC-2 CTRP2 6.27 11.4199 3.5423 10.0663
SCaBER CTRP2 6.5275 8.4857 5.1992 2.7218
HT-1197 GDSC1; CTRP2 7.1131 8.8928 5.3814 1.2782
T24 GDSC1; CTRP2 7.3077 11.7682 4.1547 5.8064
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PWR-1E GDSC1 -1.792 4.839 -3.4159 43.605
NT2-D1 GDSC1 -1.3386 2.3861 -1.9286 36.3743
SW962 GDSC1 -0.6373 1.8568 -0.9829 26.7451
KGN GDSC1 -0.203 3.0246 -0.9895 24.4055
TC-YIK GDSC1 0.2684 3.8602 -0.905 21.5016
CAL-39 GDSC1 0.6849 2.5415 0.1245 12.0338
LB831-BLC GDSC1 0.704 3.3654 -0.2515 14.8102
ACC-OV7 GDSC1 0.8586 4.8756 -0.8544 18.5517
NEC8 GDSC1 0.8931 4.3443 -0.56 16.3141
HT-3 GDSC1 1.2452 8.1136 -2.1381 24.5856
SKN GDSC1 1.2491 4.297 -0.2268 12.4233
SW954 GDSC1 1.4255 8.1629 -2.0126 23.2908
Ca Ski GDSC1 1.4755 4.2473 -0.0149 9.9753
PEO1 GDSC1 1.5255 3.6591 0.3183 7.2052
SiSo GDSC1 1.5463 6.1818 -0.9236 16.3844
BPH-1 GDSC1 1.5637 5.5618 -0.6001 14.0614
UWB1.289 GDSC1 1.5744 3.6417 0.3652 6.6778
MS751 GDSC1 1.5844 5.3793 -0.4924 13.2066
C-4-I GDSC1 1.649 17.7282 -6.6102 35.9534
SiHa GDSC1 1.6705 4.2969 0.1141 8.3222
OVMIU GDSC1 1.6757 4.6258 -0.0453 9.5343
ME-180 GDSC1 1.8874 6.5473 -0.8357 14.6129
JEG-3 GDSC1 1.9162 7.5504 -1.312 17.6143
SW756 GDSC1 1.9208 4.6645 0.1197 7.505
JAR GDSC1 1.948 5.4179 -0.2306 10.0715
OVCA420 GDSC1 1.9637 4.876 0.0473 7.9291
HEC-1 GDSC1 2.0418 7.2137 -1.0477 15.5227
DSH1 GDSC1 2.0801 5.061 0.0403 7.6436
HEY GDSC1 2.1538 6.1344 -0.4312 10.9173
C-33 A GDSC1 2.1884 4.765 0.258 5.7152
OVCA433 GDSC1 2.2043 5.3029 0.0102 7.5204
JHOS-3 GDSC1 2.2467 5.2125 0.083 6.8635
SKG-IIIa GDSC1 2.3861 9.2161 -1.7772 18.7994
DoTc2 4510 GDSC1 2.4257 4.9229 0.3371 4.5573
OMC-1 [Human cervical carcinoma] GDSC1 3.0513 6.4701 0.0064 5.4954
OV17R GDSC1 3.9326 14.7958 -3.3827 21.8154
HeLa GDSC1; CTRP2 4.848 6.33 4.6509 8.6747
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5933).
2 The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 2009 Dec 8;16(6):487-97.
3 Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J Med Chem. 2011 Jan 13;54(1):262-76. doi: 10.1021/jm1011319. Epub 2010 Dec 7.