Details of the Drug

General Information of Drug (ID: DMLMU63)

Drug Name
A-443654
Synonyms A-4436554
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 397.5
Logarithm of the Partition Coefficient (xlogp) 3.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C24H23N5O
IUPAC Name
(2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
Canonical SMILES
CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CNC5=CC=CC=C54)N
InChI
InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1
InChIKey
YWTBGJGMTBHQTM-IBGZPJMESA-N
Cross-matching ID
PubChem CID
10172943
ChEBI ID
CHEBI:91351
CAS Number
552325-16-3
TTD ID
D0OX1T

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RAC-alpha serine/threonine-protein kinase (AKT1) TTWTSCV AKT1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
RAC-alpha serine/threonine-protein kinase (AKT1) DTT AKT1 2.63E-29 0.65 1.45
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 142 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -2.8263 -1.8125 -2.8282 35.7686
MOLP-8 GDSC1 -4.9441 -0.9184 -5.1714 59.6676
697 GDSC1 -4.8688 -3.2209 -4.871 61.1518
SU-DHL-6 GDSC1 -4.8026 -3.2877 -4.8039 60.3811
GA-10 GDSC1 -4.35 -2.873 -4.352 54.7764
MV4-11 GDSC1 -4.1605 -2.436 -4.168 52.4043
Karpas-231 GDSC1 -3.9805 -2.4521 -3.9848 50.1824
SU-DHL-4 GDSC1 -3.9071 -2.8254 -3.9074 49.2667
SU-DHL-8 GDSC1 -3.7871 -1.5899 -3.8299 47.847
Karpas-620 GDSC1 -3.6991 -2.1333 -3.7066 46.6914
MOLM-13 GDSC1 -3.6223 -1.2566 -3.6921 45.9134
BL-41 GDSC1 -3.5092 -1.5242 -3.5443 44.4334
MOLT-16 GDSC1 -3.5057 -2.4832 -3.5062 44.252
Ku812 GDSC1 -3.3923 -1.304 -3.4426 43.054
SU-DHL-16 GDSC1 -3.3852 -1.8128 -3.3972 42.803
A4/Fukuda GDSC1 -3.3168 -1.3234 -3.3609 42.0996
KE-37 GDSC1 -3.2685 -1.2462 -3.318 41.5278
Namalwa GDSC1 -3.2031 -1.2517 -3.2483 40.7003
MOLT-4 GDSC1 -3.0925 -1.3415 -3.1234 39.2571
Mono-Mac-6 GDSC1 -3.0794 -0.1026 -3.3274 40.0871
P32/ISH GDSC1 -2.9917 -1.8181 -2.9954 37.8466
SIG-M5 GDSC1 -2.9485 -2.1032 -2.9488 37.2861
VL51 GDSC1 -2.9318 0.0428 -3.2051 38.4634
NALM-6 GDSC1 -2.9171 -1.2761 -2.9453 37.0583
NU-DUL-1 GDSC1 -2.8945 -1.455 -2.9093 36.6988
BALL-1 GDSC1 -2.8147 -0.0853 -3.0431 36.8612
EoL-1 GDSC1 -2.8109 -1.3374 -2.8299 35.6801
CCRF-CEM GDSC1 -2.7866 -1.2216 -2.8132 35.4217
OCI-AML-2 GDSC1 -2.7653 -1.5012 -2.7741 35.0486
KMS-12-BM GDSC1 -2.7525 -1.2322 -2.7767 34.9819
MC116 GDSC1 -2.7328 -1.8665 -2.7335 34.5919
L-363 GDSC1 -2.7323 -1.4124 -2.7442 34.6553
SUP-HD1 GDSC1 -2.7296 0.0521 -2.987 35.9869
Ramos.2G6.4C10 GDSC1 -2.7275 -1.1707 -2.7556 34.6934
MY-M12 GDSC1 -2.6867 1.1093 -3.2852 37.0809
Loucy GDSC1 -2.566 -0.6538 -2.6496 33.0156
Hs 445 GDSC1 -2.5412 -0.2097 -2.7137 33.2348
Jiyoye GDSC1 -2.5173 -0.1818 -2.6945 32.9685
JSC-1 GDSC1 -2.5168 -0.5212 -2.6202 32.5239
ML-2 GDSC1 -2.4677 -0.2914 -2.6147 32.1787
SR GDSC1 -2.438 -1.441 -2.4419 30.9269
OCI-AML-5 GDSC1 -2.4305 -0.5758 -2.517 31.3486
WIL2 NS GDSC1 -2.4302 0.0428 -2.6576 32.1959
A3/Kawakami GDSC1 -2.4079 -0.3278 -2.5415 31.3576
RS4;11 GDSC1 -2.4051 -1.1595 -2.4203 30.5868
RPMI-8402 GDSC1 -2.3834 -1.0151 -2.4085 30.3775
Daudi GDSC1 -2.347 0.6428 -2.7529 32.2189
HC-1 GDSC1 -2.3397 -0.6486 -2.4071 30.0976
LC4-1 GDSC1 -2.3166 -0.0908 -2.4982 30.5232
AMO1 GDSC1 -2.3015 -1.2698 -2.3079 29.2363
SUP-M2 GDSC1 -2.2969 -1.4609 -2.2986 29.1499
DEL GDSC1 -2.1849 0.0864 -2.4021 29.1195
Farage GDSC1 -2.1804 -0.1047 -2.3461 28.7379
HH [Human lymphoma] GDSC1 -2.1689 -0.1303 -2.3273 28.5488
DoHH2 GDSC1 -2.1681 -0.4529 -2.2559 28.0876
KOPN-8 GDSC1 -2.137 -0.0829 -2.3044 28.2106
CTV-1 GDSC1 -2.1067 -0.5744 -2.1686 27.1551
KY821 GDSC1 -2.0954 -0.1886 -2.233 27.5018
ALL-SIL GDSC1 -1.9787 0.3739 -2.2639 27.0125
Karpas-45 GDSC1 -1.9477 0.5565 -2.2909 27.0073
SUP-B15 GDSC1 -1.9471 0.2293 -2.1843 26.3088
MHH-PREB-1 GDSC1 -1.9203 0.4488 -2.2249 26.4201
OCI-Ly19 GDSC1 -1.9108 -0.566 -1.9598 24.6251
QIMR-WIL GDSC1 -1.9009 0.1528 -2.1112 25.5592
BV-173 GDSC1 -1.8953 0.0062 -2.0639 25.2138
PL-21 GDSC1 -1.8666 1.0574 -2.3878 27.1655
L-540 GDSC1 -1.8337 -0.0409 -1.9843 24.3283
SCC-3 GDSC1 -1.7756 0.0768 -1.9526 23.7803
NOMO-1 GDSC1 -1.747 0.5289 -2.0642 24.367
ARH-77 GDSC1 -1.7454 0.7777 -2.1517 24.9444
Karpas-422 GDSC1 -1.7214 0.2767 -1.953 23.4726
L-1236 GDSC1 -1.7084 0.6708 -2.0728 24.2089
OPM-2 GDSC1 -1.6911 -0.0223 -1.8335 22.4954
BC-3 GDSC1 -1.6552 0.0367 -1.8102 22.1327
DND-41 GDSC1 -1.6283 -0.2114 -1.7194 21.3703
HT GDSC1 -1.5687 1.2894 -2.1664 24.079
SU-DHL-1 GDSC1 -1.5212 -0.2513 -1.5947 19.9171
NKM-1 GDSC1 -1.515 0.2961 -1.7346 20.8249
Raji GDSC1 -1.5068 1.2166 -2.0713 23.1045
KCL-22 GDSC1 -1.4692 0.7396 -1.8415 21.3146
DB GDSC1 -1.4474 0.6573 -1.7872 20.8179
RPMI-8866 GDSC1 -1.4005 0.0907 -1.5473 18.9
JJN-3 GDSC1 -1.3961 0.1054 -1.5468 18.872
Granta-519 GDSC1 -1.3912 0.8398 -1.797 20.5863
K-562 GDSC1 -1.3847 0.031 -1.5134 18.5806
EM-2 GDSC1 -1.3459 4.1423 -3.259 29.3131
NB4 GDSC1 -1.3379 0.6149 -1.654 19.2954
BE-13 GDSC1 -1.3164 0.2775 -1.5128 18.192
Karpas-299 GDSC1 -1.3127 1.8682 -2.1546 22.6706
EJM GDSC1 -1.2794 0.1888 -1.4443 17.5138
EHEB GDSC1 -1.2703 1.05 -1.7544 19.6525
HEL GDSC1 -1.2229 0.2882 -1.4146 16.9947
GR-ST GDSC1 -1.1678 0.867 -1.5714 17.8129
CTB-1 GDSC1 -1.1635 1.0605 -1.6472 18.3369
RPMI-8226 GDSC1 -1.1607 1.7585 -1.9516 20.5056
KMOE-2 GDSC1 -1.1132 1.685 -1.8705 19.6961
U266B1 GDSC1 -1.061 0.3809 -1.2709 15.1062
GDM-1 GDSC1 -1.0498 1.8318 -1.8743 19.4165
ATN-1 GDSC1 -1.0062 4.8319 -3.2787 27.821
WSU-DLCL2 GDSC1 -0.906 1.3696 -1.5186 16.1255
MN-60 GDSC1 -0.882 0.6823 -1.195 13.6216
DG-75 GDSC1 -0.8223 1.3489 -1.4252 15.0314
LAMA-84 GDSC1 -0.782 2.2425 -1.8068 17.6805
CESS GDSC1 -0.7713 3.0833 -2.2046 20.4478
H9 GDSC1 -0.7601 0.2819 -0.911 10.9473
OCI-AML-3 GDSC1 -0.6761 0.0839 -0.7551 9.4005
KM-H2 GDSC1 -0.6677 0.5668 -0.9223 10.5442
PF-382 GDSC1 -0.632 1.51 -1.3124 13.3012
OCI-M1 GDSC1 -0.4195 0.3509 -0.5727 6.7327
MLMA GDSC1 -0.3896 1.7631 -1.2046 11.4162
NK-92MI GDSC1 -0.344 1.105 -0.8417 8.4114
ALL-PO GDSC1 -0.3131 5.4132 -2.9499 23.1393
L-428 GDSC1 -0.2541 0.9914 -0.7017 6.9404
ROS-50 GDSC1 -0.115 1.2692 -0.7116 6.446
ST486 GDSC1 -0.0758 3.9011 -1.9916 16.0925
LP-1 GDSC1 -0.018 0.9979 -0.4918 4.3419
HL-60 GDSC1 0.1903 2.9505 -1.296 9.9157
RPMI-6666 GDSC1 0.3533 6.3179 -2.8458 20.0366
ME1 GDSC1 0.358 3.7919 -1.5821 11.5274
JVM-2 GDSC1 0.6517 4.4915 -1.703 11.4638
MEG-01 GDSC1 0.7169 3.1398 -0.993 5.932
JVM-3 GDSC1 0.7298 3.3713 -1.0962 6.6781
P31/FUJ GDSC1 0.8814 2.4632 -0.568 2.418
Kasumi-1 GDSC1 0.9238 2.8903 -0.7381 3.5221
SK-MM-2 GDSC1 0.9306 5.2739 -1.8813 11.8815
HAL-01 GDSC1 0.9341 2.7481 -0.6663 2.9907
HDLM-2 GDSC1 0.9736 3.6264 -1.0523 5.6951
KG-1 GDSC1 1.0125 3.2907 -0.8689 4.2589
SKM-1 GDSC1 1.0563 5.0297 -1.6715 10.0179
EB2 GDSC1 1.1248 3.9237 -1.0941 5.6247
BC-1 GDSC1 1.1506 5.262 -1.7179 10.0825
IM-9 GDSC1 1.2167 3.6001 -0.8862 3.9264
THP-1 GDSC1 1.2645 6.0619 -2.026 11.9021
CA46 GDSC1 1.2764 9.7875 -3.8498 22.1564
RL GDSC1 1.531 2.7668 -0.375 0.4748
P30/OHK GDSC1 1.5483 7.8635 -2.7016 15.3838
TUR GDSC1 1.8576 3.7769 -0.6238 1.2763
U-698-M GDSC1 1.9305 8.4988 -2.7409 14.5585
WSU-NHL GDSC1 2.0146 3.5775 -0.4805 0.533
YT GDSC1 2.0207 3.3902 -0.4106 0.3153
SUP-T1 GDSC1 2.3843 4.0427 -0.5055 0.4101
Reh GDSC1 2.8084 14.7957 -5.1817 23.2492
⏷ Show the Full List of 142 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 -3.301 -0.6857 -3.4373 42.2737
TE-12 GDSC1 -2.3476 1.6295 -3.125 34.156
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -3.6393 -1.1885 -3.7192 46.1417
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB1 GDSC1 -3.0991 -1.5843 -3.1136 39.2502
NB69 GDSC1 -2.0957 -1.0373 -2.1071 26.6958
GOTO GDSC1 -1.8474 1.0256 -2.355 26.8477
Kelly GDSC1 -1.8323 -0.29 -1.9243 23.9235
CHP-126 GDSC1 -1.7559 -0.0948 -1.8857 23.2203
IMR-5 GDSC1 -1.7183 -0.1242 -1.8375 22.6803
GI-ME-N GDSC1 -1.7138 -0.1318 -1.8309 22.6103
SK-N-BE(2)-M17 GDSC1 -1.3969 0.5229 -1.6839 19.8235
KP-N-RT-BM-1 GDSC1 -1.1593 0.2508 -1.3333 16.0798
TGW GDSC1 -0.9397 0.4622 -1.17 13.7427
SK-N-FI GDSC1 -0.9131 0.5004 -1.156 13.5024
MHH-NB-11 GDSC1 -0.7953 0.3486 -0.9729 11.5731
SJNB-13 GDSC1 -0.7785 2.1928 -1.7796 17.4653
KP-N-YS GDSC1 -0.523 1.0211 -0.976 10.2447
SJNB-17 GDSC1 -0.5089 4.5533 -2.6925 22.4458
LA-N-6 GDSC1 -0.1499 1.3482 -0.7819 7.1354
KP-N-YN GDSC1 -0.0329 1.7142 -0.8624 7.3176
SK-N-DZ GDSC1 0.0101 1.4016 -0.6696 5.6387
NB(TU)1 GDSC1 0.126 1.5638 -0.6555 5.1161
SJNB-6 GDSC1 0.1418 3.1213 -1.4206 11.0466
SJNB-5 GDSC1 0.2351 2.791 -1.1805 8.8645
SJNB-14 GDSC1 0.8745 4.6468 -1.6148 10.1355
SJNB-10 GDSC1 1.1453 3.7961 -1.021 5.046
SJNB-7 GDSC1 1.4888 5.7626 -1.7273 9.2358
NH-12 GDSC1 2.537 4.3739 -0.5659 0.5108
SiMa GDSC1 2.6183 4.634 -0.6287 0.6659
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES4 GDSC1 -4.1167 -2.3309 -4.1264 51.8584
NOS-1 [Human HNSCC] GDSC1 -3.0771 -0.6712 -3.1979 39.5104
ES6 GDSC1 -2.9425 0.0852 -3.2284 38.6443
ES8 GDSC1 -2.7878 -1.2042 -2.8159 35.4456
EW-16 GDSC1 -2.6062 -1.2652 -2.6221 33.1045
SK-ES-1 GDSC1 -2.3454 -0.3776 -2.463 30.4828
EW-1 GDSC1 -2.1716 -0.1509 -2.3251 28.5508
H-EMC-SS GDSC1 -2.0946 -0.5809 -2.1546 26.9916
SK-PN-DW GDSC1 -2.0529 -0.2352 -2.1761 26.8795
ES1 GDSC1 -1.5485 -0.2166 -1.6316 20.321
SJSA-1 GDSC1 -1.301 0.1834 -1.4662 17.7854
EW-3 GDSC1 -0.7248 0.4715 -0.9442 10.9963
TC-71 GDSC1 -0.5087 0.9158 -0.9131 9.7016
EW-24 GDSC1 -0.2625 1.4691 -0.9434 8.8555
EW-18 GDSC1 0.4683 3.4212 -1.3126 9.1182
EW-12 GDSC1 1.5335 3.7648 -0.7796 2.6111
EW-13 GDSC1 1.6191 5.528 -1.5309 7.544
ES7 GDSC1 2.2216 9.9217 -3.2266 16.462
ES5 GDSC1 3.7429 6.6631 -0.9272 0.9873
EW-11 GDSC1 3.7719 6.1211 -0.723 0.399
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1 -5.1993 -3.0126 -5.2096 64.7341
CAL-148 GDSC1 -4.1147 -1.2801 -4.2142 51.7005
HCC1599 GDSC1 -2.6016 -1.049 -2.6347 33.1523
Evsa-T GDSC1 -2.1201 -0.1422 -2.2711 27.895
HCC2218 GDSC1 -1.9704 2.788 -3.2344 32.4463
MFM-223 GDSC1 -1.6035 0.8472 -2.0261 23.3147
BT-474 GDSC1 -1.0663 1.1991 -1.606 17.55
DU4475 GDSC1 -0.9754 0.4177 -1.1918 14.0875
HCC2157 GDSC1 -0.8803 0.8327 -1.2559 14.0579
MRK-nu-1 GDSC1 -0.4189 5.1331 -2.902 23.2971
HCC1187 GDSC1 -0.0945 3.9607 -2.0373 16.4874
COLO 824 GDSC1 1.0176 4.7565 -1.5661 9.3653
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KS-1 [Human Krukenberg tumour] GDSC1 -4.0291 -1.4767 -4.0973 50.7419
SNB-75 GDSC1 -3.2212 1.8978 -4.1574 43.5559
Onda 10 GDSC1 -2.8201 0.289 -3.1539 37.4277
Onda 11 GDSC1 -2.7743 0.3599 -3.1256 36.9748
8-MG-BA GDSC1 -2.6772 -1.1305 -2.7065 34.0727
GI-1 GDSC1 -2.2117 -1.0368 -2.2275 28.173
KALS-1 GDSC1 -2.2014 0.5387 -2.5598 30.1933
GB-1 GDSC1 -2.0743 0.5557 -2.4278 28.6201
Becker GDSC1 -1.9879 -0.4726 -2.0577 25.7225
KNS-42 GDSC1 -1.9328 1.1128 -2.4798 28.1195
KINGS-1 GDSC1 -1.6708 1.0103 -2.1611 24.5957
SF126 GDSC1 -1.6607 0.4961 -1.9594 23.1752
ONS-76 GDSC1 -1.4718 -0.0295 -1.5924 19.6136
SF268 GDSC1 -1.4003 -0.3173 -1.4513 18.2586
D-336MG GDSC1 -1.1649 0.37 -1.3794 16.4318
D-263MG GDSC1 -0.4716 3.9532 -2.3613 20.2056
NMC-G1 GDSC1 -0.2918 1.9321 -1.1985 10.9646
D-247MG GDSC1 -0.2045 2.5231 -1.4144 12.2898
KNS-81-FD GDSC1 0.3201 2.821 -1.1287 8.1774
D-502MG GDSC1 0.7456 3.1907 -0.9977 5.8892
CAS-1 GDSC1 0.7871 7.2357 -2.9599 19.2108
SF539 GDSC1 1.1684 5.0468 -1.6014 9.1999
AM-38 GDSC1 1.2146 3.0922 -0.6592 2.3941
U-87MG ATCC GDSC1 1.2414 3.0388 -0.6213 2.105
D283 Med GDSC1 2.05 3.4747 -0.4296 0.3541
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -3.0869 -0.4041 -3.263 39.8762
TGBC1TKB GDSC1 -2.8692 0.4166 -3.2465 38.1899
TGBC24TKB GDSC1 -2.115 -0.987 -2.1304 26.9625
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 -5.374 -3.272 -5.3807 66.8737
KLE GDSC1 -2.0488 2.5919 -3.2259 32.8504
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB996-RCC GDSC1 -2.9173 -0.891 -2.9895 37.3055
LB1047-RCC GDSC1 -2.8565 -0.2559 -3.0463 37.1711
OS-RC-2 GDSC1 -2.288 0.4241 -2.6164 31.062
TK-10 GDSC1 -2.2397 -0.7182 -2.2897 28.7398
RXF 393L GDSC1 -1.8776 1.6722 -2.6495 28.8315
A-704 GDSC1 -1.8219 0.542 -2.1497 25.361
HA7-RCC GDSC1 -1.1517 1.3448 -1.7575 19.0736
BB65-RCC GDSC1 -0.8147 1.2709 -1.382 14.6725
LB2241-RCC GDSC1 -0.112 0.9955 -0.5731 5.3467
RCC10RGB GDSC1 0.9759 3.1685 -0.8349 4.0988
A-498 GDSC1 1.7594 3.2069 -0.446 0.5794
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H747 GDSC1 -3.5297 -1.5991 -3.5596 44.667
LS411N GDSC1 -3.3167 -0.2459 -3.5502 42.7904
RKO GDSC1 -2.6289 -1.5002 -2.6346 33.3249
SNU-C2B GDSC1 -2.3916 -0.7701 -2.4448 30.6566
KM12 GDSC1 -2.2633 -0.5439 -2.3422 29.2176
LS123 GDSC1 -1.422 -0.0536 -1.5319 18.919
COLO 320HSR GDSC1 -0.6911 0.7423 -1.0209 11.3852
LS1034 GDSC1 -0.6617 2.2019 -1.6729 16.1551
SNU-C1 GDSC1 0.6681 4.9176 -1.9014 12.8415
MDST8 GDSC1 0.6861 3.1623 -1.0255 6.265
C2BBe1 GDSC1 0.7643 3.0988 -0.9406 5.4083
CL-11 GDSC1 1.0231 3.6092 -1.0116 5.2719
CW-2 GDSC1 2.251 4.0756 -0.5697 0.6954
NCI-H716 GDSC1 2.5286 4.4079 -0.5815 0.5635
LS513 GDSC1 2.6957 9.0622 -2.5013 11.2604
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 1.3871 3.7264 -0.8435 3.2896
Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LC-2/ad GDSC1 -5.2254 -2.6485 -5.2516 64.5573
NCI-H1355 GDSC1 -3.3023 -1.0747 -3.3751 42.0432
HOP-62 GDSC1 -2.7762 -0.4987 -2.9055 35.877
LXF 289 GDSC1 -2.7685 -1.6938 -2.7717 35.0538
NCI-H1975 GDSC1 -2.6875 -0.579 -2.7939 34.6557
NCI-H82 GDSC1 -2.6429 -1.0111 -2.6822 33.7056
Calu-6 GDSC1 -2.5865 -0.7675 -2.6535 33.1708
NCI-H720 GDSC1 -2.5049 -0.4524 -2.6207 32.4514
NCI-H1648 GDSC1 -2.4798 -0.3691 -2.6107 32.2318
NCI-H1304 GDSC1 -2.4066 0.1157 -2.6522 32.0142
LB647-SCLC GDSC1 -2.2498 1.7283 -3.0624 33.2509
NCI-H510A GDSC1 -2.0665 0.1206 -2.2826 27.6494
NCI-H847 GDSC1 -2.0102 -0.6044 -2.0606 25.8756
NCI-H209 GDSC1 -1.998 0.5551 -2.3449 27.647
IA-LM GDSC1 -1.955 0.0011 -2.1277 25.9835
NCI-H446 GDSC1 -1.9044 0.8791 -2.3601 27.2034
NCI-H1876 GDSC1 -1.7118 0.9941 -2.1984 25.0694
NCI-H524 GDSC1 -1.6429 0.5366 -1.9543 23.0413
NCI-H69 GDSC1 -1.6152 1.0456 -2.1161 23.99
Lu-139 GDSC1 -1.4156 0.6976 -1.7683 20.515
IST-SL1 GDSC1 -1.4011 0.6582 -1.7379 20.2242
NCI-H2196 GDSC1 -1.3718 0.5512 -1.667 19.5694
NCI-H1963 GDSC1 -1.3641 0.5884 -1.6723 19.5647
NCI-H211 GDSC1 -1.3433 1.0651 -1.8371 20.6171
NCI-H748 GDSC1 -1.3274 3.1501 -2.7655 26.6002
NCI-H187 GDSC1 -1.2728 3.3232 -2.7954 26.5036
SBC-1 GDSC1 -1.2315 1.1903 -1.7729 19.5859
COLO 668 GDSC1 -1.2273 0.4145 -1.4624 17.3526
COR-L95 GDSC1 -1.142 1.6012 -1.8617 19.7744
NCI-H1155 GDSC1 -1.1272 0.6864 -1.4562 16.7745
NCI-H2141 GDSC1 -0.9321 1.8502 -1.7663 18.0748
NCI-H1436 GDSC1 -0.9159 0.7476 -1.2575 14.2498
Lu-65 GDSC1 -0.9158 1.4682 -1.5734 16.5782
NCI-H345 GDSC1 -0.9086 2.8388 -2.2147 21.1368
NCI-H1581 GDSC1 -0.8691 1.9446 -1.7489 17.6538
NCI-H1694 GDSC1 -0.8193 0.8978 -1.2205 13.4941
NCI-H23 GDSC1 -0.8064 1.8161 -1.6271 16.465
CPC-N GDSC1 -0.8017 1.1496 -1.3139 14.102
HCC33 GDSC1 -0.7699 1.0572 -1.2402 13.3991
COR-L88 GDSC1 -0.7043 1.1605 -1.2208 12.9411
NCI-H526 GDSC1 -0.698 0.7279 -1.0219 11.4268
Lu-134-A GDSC1 -0.4793 2.3275 -1.5642 14.5529
DMS 79 GDSC1 -0.4616 5.34 -3.0424 24.2516
NCI-H1836 GDSC1 -0.2397 2.5039 -1.4358 12.593
NCI-H1650 GDSC1 -0.235 2.1863 -1.2737 11.3209
NCI-H1092 GDSC1 -0.1517 3.1858 -1.699 14.2474
Ms-1 GDSC1 -0.1503 2.246 -1.2289 10.6403
IST-SL2 GDSC1 -0.0533 4.516 -2.28 17.9987
NCI-H2135 GDSC1 0.1562 2.5748 -1.1359 8.7876
SHP-77 GDSC1 0.1764 2.7199 -1.1921 9.1558
NCI-H64 GDSC1 0.1851 2.8497 -1.2498 9.5754
NCI-H2081 GDSC1 0.1953 2.6559 -1.1449 8.7225
Lu-165 GDSC1 0.3778 4.0902 -1.7151 12.4502
DMS 114 GDSC1 0.4184 2.3095 -0.8013 5.3216
NCI-H2171 GDSC1 0.4715 2.2137 -0.7161 4.5088
EKVX GDSC1 0.5207 4.2233 -1.67 11.6424
NCI-H1869 GDSC1 0.7398 6.639 -2.7002 17.8557
NCI-H128 GDSC1 1.0317 7.1017 -2.7066 16.9566
NCI-H226 GDSC1 1.0372 3.3455 -0.8789 4.2741
NCI-H1838 GDSC1 1.205 3.4955 -0.8455 3.6678
NCI-H322M GDSC1 1.973 7.7902 -2.3712 12.2255
NCI-H1666 GDSC1 2.4334 4.5525 -0.6735 0.9621
NCI-H1770 GDSC1 2.7864 4.2444 -0.4309 0.13
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -1.5959 1.0037 -2.0789 23.6337
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 -3.8066 -0.8231 -3.9583 48.2096
TE-10 GDSC1 -3.186 -0.1995 -3.4191 41.2748
TE-1 GDSC1 -3.0007 -0.8153 -3.0906 38.4265
TE-11 GDSC1 -2.9535 -0.8396 -3.0361 37.8085
TE-5 GDSC1 -2.6967 0.3472 -3.0371 36.0123
TE-8 GDSC1 -2.3918 -1.1937 -2.4044 30.404
TE-6 GDSC1 -1.6719 -0.4336 -1.7241 21.6601
TE-9 GDSC1 -1.3017 0.004 -1.4156 17.4445
EC-GI-10 GDSC1 -1.0682 0.7973 -1.438 16.3382
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Kuramochi GDSC1 -2.9329 -0.536 -3.0679 37.8241
OVCAR-4 GDSC1 -2.117 -0.1604 -2.2633 27.8268
ES-2 GDSC1 -0.0528 0.9503 -0.4982 4.5254
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 -4.1848 -2.7604 -4.1868 52.7264
MZ-PC-1 GDSC1 -3.5594 -0.8154 -3.6926 45.3234
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 -1.163 0.3595 -1.3737 16.3812
IST-Mes1 GDSC1 0.4307 4.9524 -2.1027 15.0402
MSTO-211H GDSC1 2.1056 4.7102 -0.8865 2.3769
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 -1.3708 0.0986 -1.5172 18.5276
LNCaP clone FGC GDSC1 1.5305 7.9538 -2.7584 15.7688
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -0.9997 1.5738 -1.7058 17.9538
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-388 GDSC1 -3.3826 -0.5637 -3.55 43.3465
A101D GDSC1 -2.9362 -0.7338 -3.0347 37.6786
HT-144 GDSC1 -2.7602 0.2138 -3.0663 36.5933
SH-4 GDSC1 -2.1535 -1.056 -2.1659 27.4245
IST-MEL1 GDSC1 -1.923 -0.5859 -1.9699 24.7637
LB2518-MEL GDSC1 -1.742 -0.6974 -1.7642 22.3433
MZ-MEL-7 GDSC1 -1.7291 -0.8738 -1.7374 22.0939
UACC-257 GDSC1 -1.5166 -0.8963 -1.5189 19.3991
CP67-MEL GDSC1 -1.4806 0.901 -1.916 21.894
DJM-1 GDSC1 -1.4577 -0.2496 -1.5262 19.0904
LOX-IMVI GDSC1 -1.0753 1.5407 -1.7669 18.7645
CP66-MEL GDSC1 -1.0106 1.78 -1.8114 18.7748
LB373-MEL-D GDSC1 -0.992 3.2996 -2.5165 23.4922
MZ-MEL-2 GDSC1 -0.944 -0.0521 -1.0111 12.6643
MMAc-SF GDSC1 -0.4378 0.6344 -0.7137 7.8655
SK-MEL-2 GDSC1 -0.3445 3.1011 -1.8253 15.9454
GAK GDSC1 -0.0188 1.119 -0.5529 4.8263
COLO 829 GDSC1 1.1181 4.8912 -1.561 9.0475
SK-MEL-1 GDSC1 1.5746 6.7682 -2.1515 11.8764
COLO 800 GDSC1 2.3826 3.9562 -0.4756 0.331
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -3.1094 -2.047 -3.1109 39.304
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-UT-1 GDSC1 -3.9788 -1.1292 -4.0913 50.1484
VA-ES-BJ GDSC1 -2.951 -1.3803 -2.9726 37.4434
MFH-ino GDSC1 -2.5861 -1.2661 -2.6012 32.8481
SW982 GDSC1 -2.5161 -0.697 -2.5889 32.3292
SW872 GDSC1 -1.9451 0.8956 -2.41 27.7541
SK-LMS-1 GDSC1 -1.7209 0.1719 -1.9205 23.2512
TE 441.T GDSC1 -0.2678 1.2552 -0.8432 8.0968
SW684 GDSC1 1.123 3.7006 -0.9905 4.8785
EW-8 GDSC1 1.8421 3.4269 -0.4946 0.7069
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1 GDSC1 -2.2866 1.4714 -2.997 33.1491
RF-48 GDSC1 -2.1068 0.228 -2.358 28.3719
GCIY GDSC1 -1.7908 0.3942 -2.0663 24.6286
HSC-39 GDSC1 -0.6712 0.492 -0.8955 10.3666
SNU-5 GDSC1 -0.1899 1.1461 -0.718 6.7967
SNU-16 GDSC1 -0.0887 1.8183 -0.9622 8.3141
SCH GDSC1 0.4342 5.5378 -2.3918 16.9626
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 -1.9741 1.5693 -2.7073 29.7182
K5 GDSC1 -1.2256 0.4751 -1.482 17.4809
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB771-HNC GDSC1 -2.2589 -0.5784 -2.3316 29.1235
BB30-HNC GDSC1 -2.1199 -0.4857 -2.1979 27.4231
BB49-HNC GDSC1 0.3574 3.178 -1.2771 9.2052
SCC-15 GDSC1 1.2247 8.0443 -3.0272 18.2027
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 -4.8718 -2.8881 -4.8797 61.014
KGN GDSC1 -3.0025 0.2067 -3.3285 39.5091
JAR GDSC1 -2.7391 -0.248 -2.9203 35.704
OMC-1 [Human cervical carcinoma] GDSC1 -2.3506 0.3497 -2.6609 31.7135
LB831-BLC GDSC1 -2.1844 -0.0391 -2.3674 28.8978
SW954 GDSC1 -2.157 -0.6964 -2.2045 27.6912
DSH1 GDSC1 -1.9241 -0.8448 -1.942 24.5917
SW962 GDSC1 -1.8656 -0.4994 -1.9216 24.1053
NCC-IT GDSC1 -1.7704 -0.4292 -1.8308 22.9438
NEC8 GDSC1 0.5084 4.1374 -1.6368 11.4371
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8204).
2 Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. J Med Chem. 2007 Jun 28;50(13):2990-3003.