Details of the Drug

General Information of Drug (ID: DMLTAES)

Drug Name
MK-0752
Synonyms
MK-0752; 471905-41-6; MK0752; UNII-9JD9B4S53T; MK 0752; cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid; 9JD9B4S53T; 3-((1r,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid; 952578-68-6; cc-14; C21H21ClF2O4S; MLS006011072; SCHEMBL756249; SCHEMBL756248; SCHEMBL756247; CHEMBL3392635
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 442.9
Logarithm of the Partition Coefficient (xlogp) 4.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C21H21ClF2O4S
IUPAC Name
3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid
Canonical SMILES
C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
InChI
InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)
InChIKey
XCGJIFAKUZNNOR-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9803433
CAS Number
471905-41-6
UNII
9JD9B4S53T
DrugBank ID
DB12852
TTD ID
D02HNG
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-secretase (GS) TT9W8GU APH1A_HUMAN ; APH1B_HUMAN ; PEN2_HUMAN ; NICA_HUMAN ; PSN1_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Gamma-secretase (GS) DTT APH1A; APH1B; NCSTN; PSENEN; PSEN1 1.47E-02 -0.09 -0.37
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 136 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 7.3768 8.9298 5.5027 0.6656
JK1 CTRP2 8.1127 10.7926 5.0919 1.3687
JM1 CTRP2 6.3445 8.1926 5.2089 2.9734
REC-1 CTRP2 4.5802 6.997 4.1137 11.4722
AML-193 CTRP2 5.2307 6.3811 5.0462 6.0894
ME1 CTRP2 5.45 10.5839 3.2621 12.8626
DoHH2 CTRP2 5.616 11.2188 3.0921 13.2063
EoL-1 CTRP2 5.9149 6.894 5.5074 2.5203
Ku812 CTRP2 6.0262 10.0182 4.0423 8.4475
HuT 78 CTRP2 6.0557 13.8465 2.1527 15.997
Kasumi-2 CTRP2 6.1591 7.8639 5.2284 3.215
KMS-11 CTRP2 6.1606 11.5351 3.3952 10.8797
Mino CTRP2 6.164 7.1104 5.6075 1.6182
KMM-1 CTRP2 6.1737 8.714 4.8157 4.9203
ST486 CTRP2 6.2295 7.6053 5.4123 2.3205
KMS-26 CTRP2 6.2593 8.3051 5.0878 3.6249
F-36P CTRP2 6.2804 8.8872 4.8146 4.7314
U-937 CTRP2 6.3568 8.0733 5.2771 2.6703
JVM-3 CTRP2 6.3684 8.0051 5.3192 2.477
M-07e CTRP2 6.3868 8.0219 5.3245 2.4257
TF-1 CTRP2 6.3903 7.6247 5.5207 1.6166
SU-DHL-1 CTRP2 6.406 7.466 5.6077 1.2438
DND-41 CTRP2 6.4145 13.3414 2.6996 13.2022
OCI-Ly3 CTRP2 6.4448 10.9181 3.9326 8.1262
NU-DHL-1 CTRP2 6.4825 8.5747 5.1232 3.1042
SUP-T1 CTRP2 6.4903 10.4482 4.2022 6.9221
DB CTRP2 6.5245 8.374 5.2514 2.5129
RL CTRP2 6.5419 7.9495 5.4677 1.6152
MOLT-13 CTRP2 6.607 10.4257 4.3031 6.3012
GA-10 CTRP2 6.6096 8.0016 5.4871 1.4497
SUP-HD1 CTRP2 6.6212 9.9689 4.5396 5.2951
DEL CTRP2 6.6778 8.6689 5.2151 2.4362
MOLM-6 CTRP2 6.6791 9.0864 5.0144 3.2469
Reh CTRP2 6.7236 9.2885 4.9476 3.4528
EB1 CTRP2 6.7252 8.275 5.4325 1.5168
MV4-11 CTRP2 6.7391 8.5617 5.3069 1.9875
RS4;11 CTRP2 6.7798 8.9529 5.1479 2.5628
LP-1 CTRP2 6.7866 9.8253 4.7311 4.2418
SU-DHL-8 CTRP2 6.8025 8.724 5.2714 2.0442
OCI-AML-2 CTRP2 6.8173 9.0386 5.1321 2.5744
L-540 CTRP2 6.8311 8.9253 5.195 2.3069
KMS-27 CTRP2 6.8539 8.4159 5.446 1.3157
MOLP-8 CTRP2 6.9146 9.5333 4.961 3.1229
KO52 CTRP2 6.9412 10.9257 4.3048 5.7505
MOTN-1 CTRP2 6.9561 10.6009 4.474 5.0346
Hs 611.T CTRP2 6.9604 15.64 1.9869 14.9041
NB4 CTRP2 6.9698 8.2018 5.6043 0.6561
NOMO-1 CTRP2 6.9834 9.0002 5.2564 1.8782
Daudi CTRP2 7.0031 13.357 3.1531 10.3471
Peer CTRP2 7.0332 10.5028 4.5758 4.5053
BV-173 CTRP2 7.0347 9.8205 4.9042 3.1844
P3HR-1 CTRP2 7.049 9.7702 4.9375 3.0335
OCI-AML-5 CTRP2 7.0537 9.1808 5.2162 1.9476
Karpas-422 CTRP2 7.0796 9.6517 5.0132 2.696
WSU-DLCL2 CTRP2 7.1021 8.2413 4.6801 0.0693
NU-DUL-1 CTRP2 7.1023 10.0881 4.8217 3.4203
HDLM-2 CTRP2 7.1047 11.695 4.0466 6.5523
GDM-1 CTRP2 7.1489 10.7058 4.5576 4.4114
PL21 CTRP2 7.1515 8.4723 5.5819 0.5894
MC116 CTRP2 7.244 7.9388 5.8217 0.0469
BL-70 CTRP2 7.2584 8.546 5.6024 0.4633
HPB-ALL CTRP2 7.2643 10.4089 4.7758 3.3861
HD-MY-Z CTRP2 7.2679 8.9343 5.4467 0.918
Ci-1 CTRP2 7.2841 7.9922 5.8176 0.0453
KE-97 CTRP2 7.2959 9.3582 5.2776 1.4631
NCO2 CTRP2 7.2982 9.9421 5.0148 2.4223
CMK CTRP2 7.3037 8.9421 5.4616 0.8422
L-1236 CTRP2 7.307 11.0298 4.5092 4.3836
Karpas-299 CTRP2 7.3213 12.2187 3.9458 6.6306
Raji CTRP2 7.3229 8.7435 5.553 0.5583
JeKo-1 CTRP2 7.3303 9.0818 5.4162 0.9648
CML-T1 CTRP2 7.3349 9.1106 5.4062 0.9931
LAMA-84 CTRP2 7.3349 12.6211 3.7596 7.3625
SUP-B15 CTRP2 7.3614 9.6245 5.1963 1.6853
RPMI-8402 CTRP2 7.4365 16.3852 1.9833 14.0852
SU-DHL-4 CTRP2 7.4519 9.218 5.4204 0.8572
SIG-M5 CTRP2 7.4543 8.2629 5.7853 0.0526
MOLM-16 CTRP2 7.4607 9.8212 5.1648 1.6971
NALM-6 CTRP2 7.4823 9.9777 5.1074 1.8793
EM-2 CTRP2 7.495 8.82 5.5998 0.3469
Jurkat CTRP2 7.4965 10.9217 4.6836 3.4492
EHEB CTRP2 7.5176 9.5312 5.3217 1.115
SKM-1 CTRP2 7.5176 8.6573 5.6699 0.1962
SU-DHL-10 CTRP2 7.5203 8.4248 5.7534 0.075
K-562 CTRP2 7.5475 9.2032 5.4725 0.6404
A4/Fukuda CTRP2 7.5528 9.7388 5.2512 1.3155
OPM-2 CTRP2 7.5724 9.021 5.5557 0.4127
SR CTRP2 7.5728 9.0587 5.5412 0.4472
KM-H2 CTRP2 7.5976 10.7782 4.8125 2.8366
HEL 92.1.7 CTRP2 7.621 8.7276 5.6844 0.1435
PF-382 CTRP2 7.6276 16.8328 1.9061 14.0411
MM1.S CTRP2 7.6316 9.0085 5.5856 0.3191
MOLP-2 CTRP2 7.6396 10.6541 4.8942 2.4864
P31/FUJ CTRP2 7.6492 8.7233 5.6965 0.12
SU-DHL-6 CTRP2 7.6733 13.5621 3.5413 7.7266
HT CTRP2 7.6797 9.049 5.5902 0.2906
SK-MM-2 CTRP2 7.6813 9.5141 5.4096 0.7307
OCI-AML-3 CTRP2 7.6929 8.8542 5.6665 0.1523
AMO1 CTRP2 7.708 8.8533 5.6725 0.1399
KCL-22 CTRP2 7.7327 11.0657 4.7622 2.871
HL-60 CTRP2 7.7506 9.1186 5.5931 0.2594
KMS-12-BM CTRP2 7.7561 9.1505 5.5835 0.2758
KHM-1B CTRP2 7.7618 9.4394 5.4759 0.51
Ki-JK CTRP2 7.7877 9.5976 5.4252 0.6242
ALL-SIL CTRP2 7.7919 9.4424 5.4879 0.4664
P12-Ichikawa CTRP2 7.807 9.0771 5.6302 0.1783
RPMI-6666 CTRP2 7.8164 9.8493 5.3374 0.847
HEL CTRP2 7.8307 8.9621 5.6795 0.1052
SET-2 CTRP2 7.8713 8.9925 5.6836 0.0934
Kasumi-1 CTRP2 7.8839 13.3952 3.7659 6.5343
MOLT-16 CTRP2 7.9155 9.3379 5.578 0.2331
OCI-M1 CTRP2 7.9372 8.9922 5.7069 0.0615
NCI-H929 CTRP2 7.9461 9.4886 5.5348 0.3016
L-363 CTRP2 7.9519 9.3473 5.5886 0.2049
KMS-34 CTRP2 8.0027 9.2628 5.6375 0.1236
TALL-1 [Human adult T-ALL] CTRP2 8.0177 11.6621 4.6598 2.9354
KMS-20 CTRP2 8.0285 9.7347 5.4765 0.3871
KYO-1 CTRP2 8.0446 9.2003 5.674 0.0773
KMS-21-BM CTRP2 8.0684 9.6246 5.5334 0.2634
L-428 CTRP2 8.1785 15.3159 3.0441 8.9286
MHH-CALL-3 CTRP2 8.1911 11.2606 4.9334 1.8132
Karpas-620 CTRP2 8.2082 9.65 5.5775 0.1587
Ri-1 CTRP2 8.24 10.599 5.2329 0.8703
JJN-3 CTRP2 8.2897 14.833 3.351 7.59
Granta-519 CTRP2 8.2921 19.5301 1.0708 15.7999
U266B1 CTRP2 8.3222 9.956 5.5118 0.2263
THP-1 CTRP2 8.4346 10.2058 5.4651 0.2699
RPMI-8226 CTRP2 8.4523 9.9511 5.5617 0.1313
RCH-ACV CTRP2 8.5761 10.5239 5.4048 0.3303
SUP-T11 CTRP2 8.6315 10.1519 5.5566 0.1083
KMS-18 CTRP2 8.8422 15.8722 3.2207 7.3492
JVM-2 CTRP2 8.9272 11.2605 5.2737 0.4536
MHH-CALL-4 CTRP2 9.062 10.9716 5.4286 0.177
OCI-Ly19 CTRP2 9.6185 24.0136 -0.1639 17.4658
Mono-Mac-1 CTRP2 9.841 11.8725 5.3959 0.1006
EJM CTRP2 10.3772 23.5958 0.5641 14.3152
⏷ Show the Full List of 136 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 8.5669 15.3669 3.2805 7.4843
TE8 CTRP2 9.0413 18.1669 2.2622 10.5994
TE-6 CTRP2 6.4763 9.2506 3.9809 2.5137
TE-5 CTRP2 7.1414 10.1286 4.8282 3.3417
COLO 680N CTRP2 7.3249 8.8238 4.5596 0.1691
TE-9 CTRP2 7.3514 10.4538 4.8105 3.1398
OE19 CTRP2 7.5728 9.405 5.4022 0.8243
KYSE-450 CTRP2 7.6213 9.2289 5.496 0.5345
OE21 CTRP2 7.6565 13.2814 3.6654 7.2577
KYSE-180 CTRP2 7.7867 11.009 4.8198 2.5994
TE-10 CTRP2 7.8989 9.8975 5.3566 0.7415
OE33 CTRP2 7.9259 14.225 3.3961 7.9288
KYSE-30 CTRP2 7.9285 9.1583 5.6469 0.1265
KYSE-520 CTRP2 7.9392 10.266 5.2254 1.0901
KYSE-140 CTRP2 8.0492 13.0399 4.0429 5.2305
KYSE-70 CTRP2 8.0581 9.7549 5.4812 0.3659
EC-GI-10 CTRP2 8.3045 10.3034 5.3767 0.4853
KYSE-150 CTRP2 8.4028 9.6936 5.6319 0.07
KYSE-510 CTRP2 8.405 9.6884 5.6344 0.0678
TE-4 CTRP2 8.4783 15.2459 3.2797 7.6061
TE-1 CTRP2 8.629 10.7706 5.335 0.4425
TE-14 CTRP2 8.7103 10.4448 5.4839 0.1766
TE-11 CTRP2 10.1456 18.2869 2.9093 6.909
KYSE-410 CTRP2 10.9137 19.2034 2.943 5.9794
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.7144 10.0969 5.1824 1.4029
Panc 10.05 CTRP2 6.5662 8.3621 5.2863 2.3092
SNU-410 CTRP2 6.5917 12.3709 3.3249 10.3703
Hs 766T CTRP2 6.8009 9.7606 4.7728 4.0493
HuP-T4 CTRP2 7.0983 19.1234 0.3611 20.0439
SU.86.86 CTRP2 7.3345 8.8147 5.5296 0.6168
PaTu 8902 CTRP2 7.3397 9.0049 5.4534 0.84
HuP-T3 CTRP2 7.3704 10.1448 4.9656 2.5238
KP-4 CTRP2 7.4881 10.1485 5.0341 2.1381
DAN-G CTRP2 7.6376 9.0707 5.5645 0.3622
QGP-1 CTRP2 7.7123 9.2771 5.5173 0.4356
PK-45H CTRP2 7.7414 12.194 4.2428 4.8519
Panc 08.13 CTRP2 7.7532 11.9594 4.3608 4.3762
BxPC-3 CTRP2 7.8344 17.9818 1.4939 15.1388
YAPC CTRP2 7.9102 9.2212 5.6179 0.1706
PSN1 CTRP2 7.9654 13.1735 3.9256 5.7967
TCC-Pan2 CTRP2 7.9769 10.3799 5.1967 1.1493
HPAC CTRP2 7.9886 9.2736 5.6286 0.1378
MIA PaCa-2 CTRP2 7.9941 9.2358 5.6438 0.1177
Panc 02.03 CTRP2 8.144 10.455 5.2462 0.8925
Panc 03.27 CTRP2 8.1496 13.2875 3.991 5.3028
PaTu 8988t CTRP2 8.1537 9.3302 5.6681 0.0687
SUIT-2 CTRP2 8.1911 9.7 5.5535 0.1965
L3.3 CTRP2 8.2272 9.5344 5.6245 0.0998
PaTu 8988s CTRP2 8.2369 12.6519 4.3397 3.8737
CFPAC-1 CTRP2 8.2558 10.3285 5.3463 0.5756
HPAF-II CTRP2 8.3164 12.2991 4.5461 3.0322
Panc 04.03 CTRP2 8.5549 13.6085 4.0932 4.428
KP-3 CTRP2 8.6703 10.7737 5.3505 0.3979
Capan-2 CTRP2 8.6919 10.4258 5.4838 0.1804
AsPC-1 CTRP2 8.9095 15.9084 3.2467 7.1656
SW1990 CTRP2 9.4045 19.5982 1.8219 11.6312
PK-59 CTRP2 9.4421 14.9825 3.9885 3.8697
KP-2 CTRP2 9.5106 15.7352 3.692 4.8394
SNU-213 CTRP2 10.8763 25.4697 0.0037 15.2637
Panc 05.04 CTRP2 11.3779 21.8756 2.0083 8.5695
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 11.8338 33.0592 -2.9953 21.1012
Hs 940.T CTRP2 3.8875 7.9575 2.9891 17.7095
Hs 688(A).T CTRP2 5.6244 5.9921 5.5992 2.8854
IGR-37 CTRP2 5.7729 6.3342 5.6387 2.3136
CJM [Human melanoma] CTRP2 6.9674 9.6191 4.9554 3.0726
IGR-39 CTRP2 7.0315 9.4257 5.0885 2.4643
Hs 895.T CTRP2 7.0457 10.2394 4.7113 3.9402
SK-MEL-2 CTRP2 7.248 8.1837 5.7368 0.1632
SK-MEL-3 CTRP2 7.3446 8.6196 5.6121 0.3909
Hs 852.T CTRP2 7.4858 12.0109 4.1601 5.5276
WT2-iPS CTRP2 7.5079 8.9619 5.5505 0.4581
SK-MEL-31 CTRP2 7.5587 9.8052 5.2256 1.3955
SK-MEL-28 CTRP2 7.5731 8.6607 5.6901 0.147
MDA-MB-435S CTRP2 7.6061 9.5257 5.3686 0.9008
COLO 792 CTRP2 7.6725 11.8524 4.3593 4.4861
MeWo CTRP2 7.6747 9.3775 5.4613 0.5944
Hs 839.T CTRP2 7.6762 12.9363 3.8452 6.5132
A2058 CTRP2 7.6934 8.6159 5.7493 0.0545
A-375 CTRP2 7.7023 10.0022 5.2167 1.3013
RPMI-7951 CTRP2 7.7222 9.3797 5.4818 0.5161
LOX-IMVI CTRP2 7.7231 9.2572 5.5296 0.4023
Hs 936.T CTRP2 7.7444 8.7804 5.7112 0.0842
WM1799 CTRP2 7.7446 9.7148 5.358 0.8357
WM793 CTRP2 7.7468 9.2685 5.5353 0.379
HMCB CTRP2 7.8126 8.6875 5.7661 0.0311
WM266-4 CTRP2 7.8544 10.9984 4.8637 2.37
Hs 294T CTRP2 7.9073 11.3803 4.7226 2.8248
HT-144 CTRP2 7.9675 10.9696 4.9396 1.9927
SK-MEL-1 CTRP2 8.0574 9.1738 5.6874 0.0638
SK-MEL-30 CTRP2 8.0838 9.3955 5.6209 0.1285
SK-MEL-5 CTRP2 8.0888 9.2317 5.6787 0.0674
COLO 800 CTRP2 8.177 10.3184 5.3157 0.69
A101D CTRP2 8.1814 9.3017 5.6871 0.051
IPC-298 CTRP2 8.1968 9.3634 5.6718 0.0608
RVH-421 CTRP2 8.212 14.6471 3.3878 7.5555
COLO 829 CTRP2 8.2163 11.5999 4.7997 2.2401
Hs 944.T CTRP2 8.2399 15.2405 3.1224 8.5398
Mel Ho CTRP2 8.2663 12.459 4.445 3.4517
WM88 CTRP2 8.3176 12.4741 4.4682 3.3118
Mel JuSo CTRP2 8.3305 9.8901 5.5384 0.1851
G-361 CTRP2 8.4075 9.9334 5.5516 0.1515
WM983B CTRP2 8.6963 13.711 4.1307 4.1325
UACC-257 CTRP2 8.9491 15.4481 3.4865 6.2226
K029AX CTRP2 9.1465 15.1967 3.7221 5.1252
UACC-62 CTRP2 9.888 17.0643 3.3123 5.779
IGR-1 CTRP2 12.3043 29.7364 -1.0788 16.2935
WM115 CTRP2 13.2769 29.6769 -0.4259 13.533
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 7.2181 9.5466 5.1478 2.0153
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 3.885 7.9887 2.9732 17.778
SK-N-DZ CTRP2 4.7465 9.8307 2.9846 15.5661
SK-N-BE(2) CTRP2 4.8438 6.9083 4.4276 9.5371
KP-N-YN CTRP2 5.7972 11.5261 3.0949 12.8229
SiMa CTRP2 6.8701 8.8386 5.2608 1.9993
SK-N-SH CTRP2 6.892 9.3708 5.0235 2.9044
Kelly CTRP2 7.347 11.8269 4.1536 5.7531
NB1 CTRP2 7.5789 9.3955 5.4091 0.8
NH-6 CTRP2 7.6131 9.2775 5.473 0.5993
CHP-126 CTRP2 7.9478 9.9798 5.3461 0.7404
MHH-NB-11 CTRP2 8.2699 9.9099 5.5083 0.246
KP-N-SI9s CTRP2 10.2514 18.7883 2.7436 7.366
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 5.6534 9.3295 3.3858 6.2989
SNU-245 CTRP2 7.0249 9.9567 3.9763 1.9455
SNU-308 CTRP2 7.1922 8.9669 5.3925 1.1639
SNU-478 CTRP2 7.4528 12.3492 3.9745 6.3191
SNU-1196 CTRP2 7.8081 13.3412 3.7406 6.7405
HuH-28 CTRP2 7.9153 9.6554 5.459 0.4749
HuCC-T1 CTRP2 7.9744 9.3739 5.5877 0.2001
SNU-869 CTRP2 8.0268 15.1423 3.0229 9.233
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-ES-1 CTRP2 5.1814 6.312 5.0179 6.3372
Hs 888.T CTRP2 6.293 8.3064 5.1133 3.4595
SK-N-MC CTRP2 6.6804 8.1852 5.4462 1.5191
CAL-78 CTRP2 7.073 10.1063 4.7935 3.5724
MG-63 CTRP2 7.3983 17.2625 1.5199 15.7888
SJSA-1 CTRP2 7.5366 9.7102 5.2549 1.3174
A-673 CTRP2 7.8071 9.5462 5.4542 0.54
TC71 CTRP2 7.8854 9.1803 5.6231 0.169
HOS CTRP2 7.9994 9.5798 5.5225 0.3063
U2OS CTRP2 8.2245 20.4403 0.5727 17.4738
G-292 clone A141B1 CTRP2 8.8288 10.6463 5.4569 0.1871
MHH-ES-1 CTRP2 9.2661 10.6616 5.6022 0.0264
SW1353 CTRP2 9.5064 16.5267 3.3303 6.1386
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 67 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-453 CTRP2 5.3448 6.8037 4.9936 5.9837
MDA-MB-157 CTRP2 5.7675 7.5176 2.4879 0.2159
HCC2218 CTRP2 5.9712 8.9213 4.5445 6.4471
AU565 CTRP2 6.2085 8.4463 4.9773 4.1785
JIMT-1 CTRP2 6.6101 8.1553 4.52 0.5144
HMC-1-8 CTRP2 6.7518 8.2575 5.4571 1.3907
CAL-148 CTRP2 6.8399 10.618 4.3819 5.5932
BT-20 CTRP2 6.9683 9.2243 5.1427 2.3338
HCC202 CTRP2 7.0902 10.1289 4.7942 3.546
KPL-1 CTRP2 7.2342 8.1836 5.7314 0.1777
ZR-75-1 CTRP2 7.3529 10.2846 4.8902 2.8312
EFM-192A CTRP2 7.3844 13.6284 3.3029 9.1208
Hs 578Bst CTRP2 7.4423 8.7657 5.598 0.3758
SK-BR-3 CTRP2 7.6125 9.4217 5.4145 0.7615
ZR-75-30 CTRP2 7.675 9.8337 5.2741 1.1397
HCC1500 CTRP2 7.7219 11.6566 4.4827 3.9439
CAL-120 CTRP2 7.7439 9.2326 5.5477 0.3532
CAMA-1 CTRP2 7.8907 17.9352 1.5587 14.8239
MCF-7 CTRP2 7.9332 16.9551 2.072 12.9437
HCC1937 CTRP2 8.0513 13.7177 3.7238 6.4693
HCC1428 CTRP2 8.0601 9.557 5.5547 0.2296
HCC1395 CTRP2 8.0861 11.299 4.8602 2.1544
HCC1954 CTRP2 8.1026 9.972 5.4176 0.4832
HDQ-P1 CTRP2 8.2129 9.9445 5.4734 0.3249
CAL-51 CTRP2 8.2508 9.9085 5.5015 0.2628
MDA-MB-231 CTRP2 8.2803 12.0477 4.6377 2.7428
HCC1806 CTRP2 8.293 9.6837 5.5967 0.1191
MDA-MB-361 CTRP2 8.313 9.8889 5.5322 0.198
CAL-85-1 CTRP2 8.4821 15.7836 3.0259 8.5664
HCC38 CTRP2 8.4836 10.2185 5.4793 0.2343
MDA-MB-468 CTRP2 8.8012 15.8915 3.1851 7.5356
BT-549 CTRP2 9.0211 17.0847 2.7643 8.808
HCC1143 CTRP2 9.0511 11.5904 5.2013 0.5507
T-47D CTRP2 9.1623 10.916 5.4832 0.1059
Hs 578T CTRP2 9.4525 23.946 -0.2495 17.9444
HCC1419 CTRP2 9.7974 29.6174 -2.7794 23.3707
BT 231 CTRP2 4.9117 8.3086 3.8703 11.5871
BT 216 CTRP2 5.3368 6.948 4.9215 6.2909
BT 239 CTRP2 5.4928 13.5432 1.8259 18.3587
BT 159 CTRP2 6.0008 11.2022 3.429 11.0495
BT 245 CTRP2 6.0384 8.4364 4.8434 5.0598
BT 498 CTRP2 6.0851 7.0731 5.5635 1.9441
BT 286 CTRP2 6.1269 10.0804 4.0947 8.0347
BT 504 CTRP2 6.2536 9.4095 4.5329 5.9609
BT 328 CTRP2 6.463 8.2707 5.2579 2.5804
BT 444 CTRP2 6.5119 8.0744 5.3876 1.9782
BT 172 CTRP2 6.6872 9.6646 4.7381 4.3677
BT 422 CTRP2 6.7433 8.144 5.504 1.2243
BT 482 CTRP2 6.9504 8.8251 5.3169 1.6882
BT147 CTRP2 6.9949 11.36 4.1311 6.3785
BT164 CTRP2 7.0136 11.5394 4.0568 6.6539
BT 179 CTRP2 7.1212 9.3366 5.1856 1.9844
BT 330 CTRP2 7.1725 10.4873 4.6782 3.8953
BT 333 CTRP2 7.2283 10.6736 4.6266 4.0241
BT 232 CTRP2 7.442 9.7426 5.1892 1.63
BT 145 CTRP2 7.4442 8.9197 5.5384 0.5244
BT 131 CTRP2 7.559 13.2639 3.6057 7.6405
BT 187 CTRP2 7.6394 10.0006 5.1842 1.4627
BT 416 CTRP2 7.7497 9.0707 5.6103 0.2283
BT 340 CTRP2 7.7848 11.0221 4.8128 2.6271
BT 112 CTRP2 7.8086 13.1262 3.8439 6.3316
BT 359 CTRP2 7.8106 13.9721 3.4385 7.9304
BT 440 CTRP2 7.8487 9.6334 5.4385 0.5572
BT 228 CTRP2 7.9391 15.2328 2.9174 9.7709
BT 320 CTRP2 7.9399 8.8077 5.769 0.0216
BT 224 CTRP2 8.0546 9.6538 5.5173 0.297
BT 271 CTRP2 8.5195 17.5182 2.2164 11.5157
⏷ Show the Full List of 67 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.7211 8.6703 5.7405 0.0588
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 4.7874 8.2673 3.7672 12.3091
SW1783 CTRP2 6.1981 10.3578 4.0144 8.2364
DK-MG CTRP2 7.0577 8.9671 5.3162 1.5704
SNU-489 CTRP2 7.0582 9.2667 5.1793 2.0824
NMC-G1 CTRP2 7.1995 17.7071 1.1455 17.4014
KNS-81 CTRP2 7.236 8.5721 5.5815 0.5341
SNU-201 CTRP2 7.2684 11.4348 3.4572 3.6467
SNU-466 CTRP2 7.3188 11.8063 4.144 5.8333
SW1088 CTRP2 7.4109 11.1962 4.4989 4.2828
GaMG CTRP2 7.4281 10.0198 5.0571 2.1184
SNU-738 CTRP2 7.5119 8.8196 5.6071 0.3233
KNS-60 CTRP2 7.5492 8.6244 5.694 0.1472
LN-229 CTRP2 7.6286 11.352 4.566 3.7386
M059K CTRP2 7.6393 11.7912 4.3667 4.5004
SNU-626 CTRP2 7.641 9.1967 5.5174 0.4704
Hs 683 CTRP2 7.6506 10.7824 4.8424 2.6653
LN-18 CTRP2 7.6761 8.567 5.7597 0.0479
SF295 CTRP2 7.6854 8.8669 5.6591 0.1655
U-87MG ATCC CTRP2 7.6864 9.814 5.2882 1.0867
42-MG-BA CTRP2 7.6887 10.7845 4.8639 2.5439
Becker CTRP2 7.6948 10.2929 5.0867 1.7431
U-118MG CTRP2 7.7261 11.996 4.3263 4.5453
SF126 CTRP2 7.7512 9.9027 5.2835 1.052
CCF-STTG1 CTRP2 7.8962 13.0526 3.9374 5.8432
GMS-10 CTRP2 7.9181 10.9875 4.9044 2.1619
CAS-1 CTRP2 7.9467 9.3504 5.5855 0.2114
SF268 CTRP2 7.9881 9.7849 5.4405 0.4837
ONS-76 CTRP2 8.0818 9.82 5.4665 0.3866
YH-13 CTRP2 8.0964 12.4833 4.3319 4.0658
U-251MG CTRP2 8.1255 9.7313 5.5169 0.2745
KG-1-C CTRP2 8.1804 12.7894 4.2421 4.3057
8-MG-BA CTRP2 8.2374 9.9137 5.4943 0.2791
GB-1 CTRP2 8.4142 16.7286 2.5251 10.5427
SF539 CTRP2 8.4669 9.9659 5.5618 0.1286
SNU-1105 CTRP2 8.5602 15.6397 3.1466 8.0016
KALS-1 CTRP2 8.6904 13.1271 4.3893 3.2101
SNB-75 CTRP2 9 10.8607 5.4446 0.1695
T98G CTRP2 9.3978 15.867 3.5664 5.4097
DBTRG-05MG CTRP2 9.9519 18.2873 2.7918 7.5435
Daoy CTRP2 9.9565 17.2034 3.2896 5.7852
A-172 CTRP2 10.1336 21.1826 1.5518 11.5536
GOS-3 CTRP2 10.4526 17.0024 3.6565 4.048
TM-31 CTRP2 11.1262 19.2802 3.028 5.4912
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-3 CTRP2 6.1699 10.1903 4.0751 8.0355
AN3-CA CTRP2 7.3444 11.5427 4.2887 5.2132
RL95-2 CTRP2 7.395 12.5576 3.8332 6.9742
HEC-265 CTRP2 7.4016 8.5893 5.6482 0.2811
HEC-6 CTRP2 7.4205 9.1408 5.4369 0.8299
HEC-151 CTRP2 7.4859 9.1048 5.4834 0.649
ESS-1 CTRP2 7.6476 11.8197 4.3586 4.5212
EFE-184 CTRP2 7.7515 9.1811 5.5702 0.3036
MFE-319 CTRP2 7.7904 9.2606 5.5564 0.3164
EN CTRP2 7.8624 9.6402 5.4419 0.5417
HEC-251 CTRP2 7.8653 9.4354 5.5216 0.3586
JHUEM-7 CTRP2 7.8856 10.0472 5.2895 0.9382
HEC-108 CTRP2 8.0295 11.3047 4.8264 2.3266
JHUEM-2 CTRP2 8.3653 14.7997 3.4171 7.2328
HEC-59 CTRP2 8.3838 9.9418 5.5399 0.1712
KLE CTRP2 8.4003 10.864 5.2006 0.862
HEC-1-A CTRP2 8.9381 10.4081 5.5763 0.0586
MFE-296 CTRP2 8.9394 10.3356 5.6006 0.0442
HEC-1-B CTRP2 9.9257 20.3111 1.8285 10.9071
HEC-50B CTRP2 10.6205 18.6444 3.0257 5.9986
JHUEM-1 CTRP2 16.3385 40.676 -3.6287 17.3993
Ishikawa (Heraklio) 02 ER- CTRP2 8.115 19.4492 0.9796 16.38
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB CTRP2 6.0818 7.0449 5.5749 1.9023
UO-31 CTRP2 6.5748 8.2855 5.3292 2.1236
SNU-1272 CTRP2 7.3739 10.6648 4.7259 3.4396
KMRC-1 CTRP2 7.5589 9.2369 5.4642 0.6562
OS-RC-2 CTRP2 7.59 12.8477 3.8287 6.7033
TUHR10TKB CTRP2 7.6813 8.9132 5.6409 0.1963
TUHR4TKB CTRP2 7.7699 9.4218 5.4863 0.4809
BFTC-909 CTRP2 7.9356 9.2626 5.6127 0.1719
ACHN CTRP2 8.0793 9.9081 5.4321 0.4612
Caki-2 CTRP2 8.1297 13.5102 3.8734 5.783
KMRC-2 CTRP2 8.2779 13.3163 4.0584 4.8852
VMRC-RCW CTRP2 8.2825 9.6736 5.5964 0.1212
786-O CTRP2 8.4067 10.1507 5.4743 0.2629
KMRC-3 CTRP2 8.4418 10.1854 5.4752 0.2516
KMRC-20 CTRP2 8.7151 17.3746 2.4209 10.4883
Caki-1 CTRP2 8.8235 13.2285 4.4186 2.9788
769-P CTRP2 8.8357 10.1129 5.6391 0.0317
TUHR14TKB CTRP2 8.9653 11.2951 5.2762 0.4357
VMRC-RCZ CTRP2 9.1149 10.6433 5.558 0.0558
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 CTRP2 5.446 11.7 2.045 12.5713
SNU-81 CTRP2 6.0265 7.2622 5.4205 2.6574
OUMS-23 CTRP2 6.2288 9.7212 3.6042 4.4059
NCI-H747 CTRP2 6.2652 8.3321 5.0789 3.6516
HT115 CTRP2 6.6509 7.9758 4.6058 0.2899
SW620 CTRP2 6.7697 8.2513 5.4708 1.3184
SW1417 CTRP2 6.8453 9.7855 4.792 3.9046
SNU-61 CTRP2 7.1028 9.6166 5.0445 2.5453
SNU-C1 CTRP2 7.3064 9.3858 5.2712 1.475
CW-2 CTRP2 7.3382 12.495 3.8234 7.0999
SNU-407 CTRP2 7.437 10.2139 4.9742 2.4152
HCC-56 CTRP2 7.4935 8.324 5.7783 0.0539
SNU-503 CTRP2 7.5152 14.2072 3.1144 9.6605
T84 CTRP2 7.5274 12.9348 3.7432 7.1378
C2BBe1 CTRP2 7.6154 10.0872 5.1334 1.6571
SW948 CTRP2 7.633 9.1545 5.5304 0.4432
SK-CO-1 CTRP2 7.6711 9.5316 5.3976 0.7709
LoVo CTRP2 7.6822 10.2564 5.0959 1.7235
LS513 CTRP2 7.6837 9.3367 5.4815 0.5373
NCI-H716 CTRP2 7.712 13.4947 3.6008 7.4331
COLO205 CTRP2 7.7846 9.423 5.4923 0.4596
RKO CTRP2 7.8182 11.9867 4.3893 4.1839
SNU-C4 CTRP2 7.8244 8.8273 5.7234 0.061
HCT 8 CTRP2 7.882 9.0195 5.6782 0.0977
SW48 CTRP2 7.9 15.076 2.966 9.643
LS411N CTRP2 7.9153 9.3604 5.5697 0.2477
HT-29 CTRP2 7.923 18.782 1.1654 16.0929
LS123 CTRP2 7.9262 10.3064 5.2021 1.1702
MDST8 CTRP2 7.948 12.4576 4.2514 4.5536
NCI-H508 CTRP2 7.9757 9.4606 5.5569 0.2512
HCT 116 CTRP2 7.9926 9.6101 5.5085 0.3359
COLO201 CTRP2 8.007 10.3342 5.2303 1.0277
HCT 15 CTRP2 8.0919 9.887 5.4454 0.4269
KM12 CTRP2 8.1442 9.8083 5.4961 0.3059
LS1034 CTRP2 8.1973 9.6269 5.5816 0.1556
RCM-1 [Human ESC] CTRP2 8.2824 9.7358 5.5748 0.147
SNU-C5 CTRP2 8.3333 10.167 5.4395 0.3469
CCK-81 CTRP2 8.3527 12.7485 4.3647 3.652
SNU-C2A CTRP2 8.4289 15.7025 3.029 8.6291
COLO 678 CTRP2 8.5852 17.2943 2.3703 10.8605
SNU-1033 CTRP2 8.5951 10.6051 5.3826 0.3639
GP2d CTRP2 8.7392 10.6769 5.4126 0.2703
HT-55 CTRP2 8.8696 16.5143 2.9352 8.3787
COLO 320 CTRP2 8.9151 11.5246 5.1694 0.6759
CL-11 CTRP2 8.9557 11.47 5.2071 0.5764
LS180 CTRP2 10.1196 19.2546 2.4477 8.5457
DLD-1 CTRP2 11.5417 27.5747 -0.5559 15.9137
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PLC/PRF/5 CTRP2 6.8115 9.2392 5.0322 2.9819
SNU-423 CTRP2 7.0534 9.8034 4.9247 3.0782
SNU-761 CTRP2 7.1795 8.7078 4.5463 0.2254
Hep 3B2.1-7 CTRP2 7.2568 10.6689 4.6477 3.9012
HuH-1 CTRP2 7.4165 8.9053 5.5314 0.5597
SNU-886 CTRP2 7.6187 9.2927 5.4695 0.6052
SK-HEP-1 CTRP2 7.7488 8.9321 5.6598 0.1484
Hep-G2 CTRP2 7.7844 9.226 5.5669 0.2978
SNU-475 CTRP2 7.7977 11.4711 4.6157 3.3453
SNU-878 CTRP2 7.8354 9.7041 5.4046 0.6509
SNU-449 CTRP2 7.9564 10.8534 4.9843 1.8507
JHH-5 CTRP2 8.0512 11.3421 4.8219 2.3209
HLF CTRP2 8.2337 10.8211 5.1398 1.1359
JHH-1 CTRP2 8.2634 11.7504 4.7595 2.334
HuH-6 CTRP2 8.315 11.8864 4.7282 2.3931
SNU-387 CTRP2 8.4408 10.6611 5.2978 0.6008
JHH-4 CTRP2 8.5688 14.4979 3.6906 5.9238
SNU-398 CTRP2 8.6094 10.6183 5.3834 0.3576
Li-7 CTRP2 9.0524 10.915 5.4447 0.1602
JHH-2 CTRP2 9.0617 19.4386 1.6646 12.6524
SNU-182 CTRP2 9.6771 22.9001 0.4185 15.7181
JHH-6 CTRP2 10.8541 24.7015 0.3556 14.296
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 137 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2141 CTRP2 0.7568 8.218 -4.9884 15.3326
COR-L88 CTRP2 2.4461 15.7802 -2.072 36.0224
DV-90 CTRP2 3.9155 10.0923 2.0556 21.1943
HCC1438 CTRP2 5.999 6.8979 5.5793 2.0445
NCI-H2444 CTRP2 6.0374 7.7154 4.4175 1.3133
DMS 53 CTRP2 6.082 9.4957 4.35 7.0494
NCI-H1105 CTRP2 6.1629 8.1045 5.1114 3.6991
NCI-H1975 CTRP2 6.4251 10.9844 3.8841 8.3637
NCI-H1092 CTRP2 6.6017 9.7087 4.6535 4.8548
NCI-H889 CTRP2 6.901 9.1559 5.1315 2.4646
COR-L95 CTRP2 6.9014 8.9138 5.2455 2.0195
ChaGo-K-1 CTRP2 6.9395 12.4433 3.5568 8.8214
NCI-H1581 CTRP2 6.9582 12.0484 3.7658 7.9362
HCC95 CTRP2 6.983 8.3953 4.5833 0.2194
COLO 668 CTRP2 7.0836 9.4628 5.1041 2.3392
NCI-H1341 CTRP2 7.0959 14.2812 2.7662 11.7188
NCI-H841 CTRP2 7.1061 9.0212 5.32 1.5046
NCI-H526 CTRP2 7.1424 9.1222 5.2957 1.5546
NCI-H2196 CTRP2 7.1494 9.8556 4.9622 2.8061
NCI-H838 CTRP2 7.1982 8.6757 5.5204 0.7408
DMS 114 CTRP2 7.2027 9.2252 5.2841 1.5335
NCI-H810 CTRP2 7.2353 9.4381 5.2072 1.7774
RERF-LC-Ad1 CTRP2 7.2371 8.0519 5.78 0.0971
BEN CTRP2 7.254 8.406 5.6555 0.3316
NCI-H1339 CTRP2 7.263 9.0221 5.4065 1.0531
NCI-H2106 CTRP2 7.2775 11.1347 4.4391 4.7047
NCI-H1915 CTRP2 7.3045 9.7125 5.1237 2.0088
NCI-H1734 CTRP2 7.336 11.1988 4.4479 4.5878
NCI-H2126 CTRP2 7.342 11.7433 4.1904 5.612
NCI-H1155 CTRP2 7.3424 9.4273 5.273 1.4339
MOR/CPR CTRP2 7.3579 8.7199 5.5786 0.4686
NCI-H446 CTRP2 7.378 10.4672 4.821 3.0662
NCI-H2110 CTRP2 7.389 10.0081 5.0393 2.2269
NCI-H2122 CTRP2 7.4381 10.6449 4.7759 3.1656
NCI-H2009 CTRP2 7.4491 9.6674 4.299 0.6366
NCI-H69 CTRP2 7.4725 10.0845 5.0538 2.0828
NCI-H2172 CTRP2 7.4898 10.8683 4.7043 3.3778
NCI-H1568 CTRP2 7.5128 13.5757 3.4213 8.4471
SHP-77 CTRP2 7.5162 8.8819 5.5851 0.3708
NCI-H1703 CTRP2 7.5233 11.7116 4.3283 4.8063
VMRC-LCD CTRP2 7.5476 11.0097 4.6747 3.4201
NCI-H661 CTRP2 7.5492 10.1822 5.0542 2.001
LK2 CTRP2 7.5555 8.3697 5.7844 0.0415
SK-LU-1 CTRP2 7.5828 10.0843 5.1166 1.7465
NCI-H322 CTRP2 7.6037 10.6333 4.8824 2.5693
NCI-H2286 CTRP2 7.6478 10.0714 5.1579 1.5435
NCI-H650 CTRP2 7.6542 10.0499 5.1707 1.4944
CAL-12T CTRP2 7.6898 15.9769 2.3738 12.2271
RERF-LC-MS CTRP2 7.7009 11.295 4.6376 3.3765
HCC366 CTRP2 7.7087 9.6222 5.3786 0.8003
NCI-H2170 CTRP2 7.7311 11.6492 4.492 3.8967
RERF-LC-A1 CTRP2 7.738 9.6206 5.3931 0.7406
NCI-H1793 CTRP2 7.7573 9.27 5.5391 0.3661
PC-14 CTRP2 7.8043 11.5137 4.6001 3.3961
HOP-92 CTRP2 7.8119 10.1069 5.2284 1.1759
NCI-H226 CTRP2 7.8168 9.0726 5.6355 0.1676
NCI-H1623 CTRP2 7.8271 12.9343 3.9479 5.896
LXF 289 CTRP2 7.8421 12.2956 4.2599 4.6547
Lu-99 CTRP2 7.8437 12.455 4.1859 4.9403
NCI-H1563 CTRP2 7.86 9.3137 5.5648 0.2747
NCI-H647 CTRP2 7.8712 13.2022 3.8496 6.2225
NCI-H1869 CTRP2 7.8862 13.3737 3.7777 6.4846
SBC-5 CTRP2 7.8871 8.8137 5.7494 0.0353
NCI-H460 CTRP2 7.8874 8.9941 5.6888 0.0854
EKVX CTRP2 7.9393 11.4781 4.6971 2.8835
NCI-H211 CTRP2 7.9416 13.2253 3.8854 5.986
LCLC-103H CTRP2 7.9526 9.012 5.7056 0.0608
NCI-H1666 CTRP2 7.956 11.1573 4.8505 2.3142
NCI-H2405 CTRP2 7.976 9.9157 5.3843 0.6251
DMS 79 CTRP2 7.976 9.6265 5.4956 0.3685
Calu-3 CTRP2 7.9788 10.0959 5.3139 0.8091
Calu-1 CTRP2 7.984 9.5884 5.5131 0.3301
IA-LM CTRP2 7.9869 9.3696 5.594 0.1871
LC-1/sq-SF CTRP2 7.995 9.6508 5.4943 0.3637
HCC1833 CTRP2 7.9968 11.7019 4.6296 3.0686
SK-MES-1 CTRP2 7.9981 12.0328 4.4793 3.6255
NCI-H1355 CTRP2 8.0616 13.1766 3.9867 5.4324
LUDLU-1 CTRP2 8.0617 14.2631 3.4704 7.4444
HCC1195 CTRP2 8.0666 9.3572 5.6279 0.1232
Sq-1 CTRP2 8.09 9.3025 5.6552 0.0892
SW1271 CTRP2 8.0908 10.2543 5.3021 0.7734
NCI-H1650 CTRP2 8.0938 10.1938 5.3275 0.7053
NCI-H196 CTRP2 8.1048 9.2309 5.6846 0.0607
SW1573 CTRP2 8.1164 12.7626 4.215 4.4856
HCC78 CTRP2 8.1236 9.9889 5.4201 0.4685
NCI-H292 CTRP2 8.1368 11.3288 4.8749 2.0571
NCI-H2171 CTRP2 8.1414 9.5066 5.6032 0.1392
HCC2279 CTRP2 8.1543 13.3472 3.966 5.3933
HCC1588 CTRP2 8.1952 9.7623 5.5327 0.2274
NCI-H1373 CTRP2 8.2122 12.4316 4.4255 3.5833
NCI-H2085 CTRP2 8.2222 10.6284 5.2128 0.936
HCC2935 CTRP2 8.2336 9.879 5.5055 0.2612
EBC-1 CTRP2 8.2353 10.0871 5.4295 0.4025
KNS-62 CTRP2 8.2456 9.635 5.5964 0.1277
NCI-H2291 CTRP2 8.2734 10.1881 5.4073 0.4332
NCI-H1299 CTRP2 8.2782 10.2566 5.3834 0.4821
EPLC-272H CTRP2 8.2851 13.6731 3.8966 5.4942
NCI-H1755 CTRP2 8.3132 10.0357 5.4796 0.2813
NCI-H2029 CTRP2 8.319 10.0547 5.4749 0.2876
Calu-6 CTRP2 8.3235 9.8655 5.5444 0.1783
HARA [Human squamous cell lung carcinoma] CTRP2 8.3514 10.783 5.2106 0.8641
NCI-H2228 CTRP2 8.3567 14.0632 3.7593 5.9295
LCLC-97TM1 CTRP2 8.3727 13.534 4.0163 4.9299
NCI-H1435 CTRP2 8.4082 10.0019 5.5278 0.1822
NCI-H727 CTRP2 8.4259 10.0746 5.5087 0.2049
NCI-H2081 CTRP2 8.492 23.0579 -0.5187 20.1444
HCC2108 CTRP2 8.493 10.1078 5.522 0.1719
NCI-H2030 CTRP2 8.5063 10.4545 5.4026 0.3567
A-549 CTRP2 8.5283 12.5479 4.555 2.7891
HOP-62 CTRP2 8.5955 10.3736 5.4663 0.2257
LOU-NH91 CTRP2 8.6069 10.2213 5.524 0.1474
NCI-H1395 CTRP2 8.6243 10.7968 5.3233 0.4677
HCC4006 CTRP2 8.6428 16.2443 2.9135 8.7674
NCI-H2342 CTRP2 8.7338 15.2448 3.4458 6.6416
NCI-H441 CTRP2 8.7804 10.7012 5.4195 0.2493
NCI-H1184 CTRP2 8.7939 10.6213 5.4528 0.1995
NCI-H1838 CTRP2 8.8057 10.5272 5.4899 0.1516
HCC15 CTRP2 8.811 10.6853 5.4366 0.2176
NCI-H522 CTRP2 8.8497 17.1178 2.635 9.5154
NCI-H358 CTRP2 8.9237 10.7915 5.4409 0.1883
NCI-H23 CTRP2 8.9258 17.0374 2.724 9.0843
NCI-H1944 CTRP2 9.0111 16.099 3.2221 7.1289
HCC827 CTRP2 9.0729 17.6035 2.5521 9.5127
NCI-H2023 CTRP2 9.1133 16.0609 3.3041 6.6985
DMS 273 CTRP2 9.2804 18.5751 2.2273 10.3935
COLO 699 CTRP2 9.2821 15.8728 3.4946 5.8
T3M-10 CTRP2 9.2961 20.1303 1.4926 12.8932
HCC1171 CTRP2 9.4425 19.3891 1.9473 11.1489
HCC44 CTRP2 9.4483 19.7801 1.7644 11.7663
NCI-H1573 CTRP2 9.5508 28.303 -2.315 22.7727
COR-L105 CTRP2 9.7012 17.6816 2.9174 7.3945
NCI-H2087 CTRP2 9.7656 19.7062 2.0101 10.5005
NCI-H1792 CTRP2 10.201 19.6993 2.2919 8.984
NCI-H520 CTRP2 10.3323 22.6821 0.9705 13.143
Lu-65 CTRP2 11.5406 25.5006 0.4267 13.227
RERF-LC-Ad2 CTRP2 14.0979 29.0284 0.3678 10.5803
Hs 888.Lu CTRP2 7.1231 9.7638 4.9885 2.7371
⏷ Show the Full List of 137 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 5.8099 7.3658 5.1794 4.1154
Aska-SS CTRP2 8.1271 17.3619 2.0135 12.8461
BT-12 CTRP2 6.0762 6.8818 5.6519 1.5895
Tm87-16 CTRP2 6.1205 7.7403 5.259 3.1573
TTC-709 CTRP2 6.2376 8.2431 5.1016 3.6054
Rh41 CTRP2 7.0482 8.4518 4.5879 0.1938
MES-SA CTRP2 7.0879 10.6279 4.5532 4.5168
SW982 CTRP2 7.2906 8.6289 5.5841 0.4932
TE 441.T CTRP2 7.4856 9.1022 5.4843 0.6467
A-204 CTRP2 7.5514 10.1391 5.0747 1.9254
SK-LMS-1 CTRP2 7.6633 10.9823 4.7587 2.9632
TE 617.T CTRP2 7.6689 9.2715 5.5005 0.4975
RKN CTRP2 7.7454 8.8604 5.6838 0.1164
BT-16 CTRP2 7.7455 9.2318 5.5487 0.3505
HT-1080 CTRP2 7.8932 10.8153 4.9665 1.9702
G-402 CTRP2 8.087 15.0588 3.105 8.8271
GCT CTRP2 8.1101 9.6456 5.542 0.2362
G-401 CTRP2 8.9937 15.9533 3.2792 6.9386
Rh18 CTRP2 9.0544 17.8095 2.4417 9.9373
Hs 729.T CTRP2 9.8778 17.165 3.2607 5.9719
RD CTRP2 13.0631 26.9179 0.7147 10.6761
SK-UT-1 CTRP2 13.5692 26.9618 0.9916 9.3764
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 6.6832 8.5293 5.2855 2.147
P-STS CTRP2 6.7911 11.2714 4.0241 7.1491
H-STS CTRP2 7.6849 13.8554 3.4073 8.2408
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.7358 8.984 5.1033 2.8038
COV434 CTRP2 5.8818 8.0416 4.9073 5.1032
A2780 CTRP2 6.9071 9.5102 4.967 3.1092
OAW42 CTRP2 7.0018 8.9236 5.3028 1.682
RMG-I CTRP2 7.1294 10.9924 4.4059 5.0524
OV56 CTRP2 7.1708 8.2528 5.6787 0.3173
MCAS CTRP2 7.298 10.6379 4.6896 3.6806
TOV-112D CTRP2 7.4009 10.3113 4.9075 2.7077
Kuramochi CTRP2 7.4646 11.3531 4.4599 4.3649
SNU-119 CTRP2 7.5048 12.5064 3.9346 6.4034
TOV-21G CTRP2 7.5485 8.7114 5.6623 0.1998
SNU-8 CTRP2 7.5762 12.767 3.0335 4.9504
JHOS-2 CTRP2 7.6777 12.556 4.0286 5.7825
TYK-nu CTRP2 7.6912 9.7791 5.3053 1.0303
FU-OV-1 CTRP2 7.7311 11.9825 4.3358 4.502
HEY A8 CTRP2 7.8265 9.2899 5.5602 0.2955
IGROV-1 CTRP2 7.9381 11.1178 4.8579 2.3058
SNU-840 CTRP2 7.96 11.2985 4.7898 2.5259
ES2 CTRP2 7.9858 9.002 5.7204 0.046
ONCO-DG-1 CTRP2 8.0479 9.5515 5.552 0.2377
JHOM-1 CTRP2 8.0711 9.7065 5.5044 0.3155
COV644 CTRP2 8.0764 14.2885 3.4681 7.4325
EFO-27 CTRP2 8.0831 10.3692 5.2524 0.9139
OVK18 CTRP2 8.0952 9.4465 5.6073 0.1434
OVISE CTRP2 8.1099 9.2885 5.6669 0.0752
JHOC-5 CTRP2 8.1336 9.411 5.6335 0.1051
OVCAR-4 CTRP2 8.2866 10.3764 5.3411 0.5731
Caov-3 CTRP2 8.2885 10.1916 5.4122 0.4171
OC 314 CTRP2 8.296 9.4013 5.6929 0.0379
SK-OV-3 CTRP2 8.3029 9.907 5.522 0.2157
EFO-21 CTRP2 8.3708 9.9826 5.5207 0.2008
DOV13 CTRP2 8.3811 9.9344 5.5415 0.1697
OVCAR-5 CTRP2 8.3939 10.0575 5.5028 0.2216
COV362 CTRP2 8.4081 20.5108 -0.0966 15.4088
OVTOKO CTRP2 8.5493 15.7048 3.1085 8.1608
OV-90 CTRP2 8.6227 9.9629 5.6172 0.0589
OVCAR-8 CTRP2 8.7482 10.3493 5.5304 0.1173
OAW28 CTRP2 8.7562 15.6958 3.2483 7.3569
OVSAHO CTRP2 9.5392 19.7257 1.8513 11.3459
OV7 CTRP2 12.2095 34.4755 -3.4187 21.4599
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.4757 9.7239 5.2161 1.504
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-MESO-1 CTRP2 6.6286 8.1165 4.5431 0.4448
NCI-H2052 CTRP2 8.0351 11.6714 4.6657 2.8951
MSTO-211H CTRP2 8.2489 10.1565 5.409 0.4394
IST-Mes1 CTRP2 8.2904 10.2427 5.3937 0.4548
JL-1 CTRP2 8.4089 12.8406 4.356 3.6222
NCI-H28 CTRP2 8.7001 10.4497 5.4784 0.1857
NCI-H2452 CTRP2 9.0311 10.8613 5.4556 0.1517
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 6.5796 9.3894 4.7943 4.3074
PaCa-3 CTRP2 7.658 9.2677 5.4972 0.5116
DU145 CTRP2 7.8812 11.3261 4.7318 2.8195
22Rv1 CTRP2 8.1263 11.1215 4.959 1.7844
LNCaP clone FGC CTRP2 8.3188 10.4193 5.3385 0.5642
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 7.7769 13.1066 3.832 6.4231
A-253 CTRP2 8.1339 10.9928 5.0181 1.5856
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GSU CTRP2 5.9804 6.6077 4.8412 0.0754
HGC-27 CTRP2 6.1976 7.1904 5.5935 1.6195
SNU-5 CTRP2 6.2064 8.1718 4.31 1.5401
SNU-16 CTRP2 6.4892 7.8261 5.4914 1.5931
Fu97 CTRP2 6.6757 8.7154 5.1913 2.5348
ECC12 CTRP2 6.8342 7.981 4.6742 0.1188
MKN45 CTRP2 7.0844 8.1316 5.6879 0.3394
SH-10-TC CTRP2 7.091 9.3035 5.1825 2.0314
GSS CTRP2 7.3178 8.8516 5.5064 0.6956
SNU-1 CTRP2 7.3768 10.248 4.922 2.6814
SNU-620 CTRP2 7.5196 8.67 5.6661 0.2024
SNU-668 CTRP2 7.5928 9.3608 5.43 0.7305
23132/87 CTRP2 7.6054 12.1691 4.165 5.3415
HuG1-N CTRP2 7.6171 11.6609 4.4137 4.3451
OCUM-1 CTRP2 7.6189 15.0737 2.7652 10.8564
Hs 746.T CTRP2 7.6599 10.8403 4.8216 2.7321
SNU-216 CTRP2 7.6642 9.3053 5.4852 0.5386
MKN1 CTRP2 7.8559 9.2212 5.5971 0.2184
SNU-601 CTRP2 7.9325 10.2078 5.2462 1.0329
NUGC-3 CTRP2 7.9554 9.647 5.4792 0.4116
NUGC-4 CTRP2 7.9729 9.7499 5.4474 0.4748
SNU-719 CTRP2 8.0305 10.4108 5.2102 1.0704
ECC10 CTRP2 8.0597 9.4297 5.6 0.1608
IM95 CTRP2 8.2914 14.6566 3.4363 7.259
AGS CTRP2 8.3273 9.7977 5.5696 0.1447
NCI-N87 CTRP2 8.4297 10.1922 5.4681 0.2665
MKN7 CTRP2 8.5254 10.3038 5.4647 0.2458
NCC-StC-K140 CTRP2 8.533 11.615 4.958 1.4641
MKN74 CTRP2 8.9845 11.5232 5.199 0.5818
LMSU CTRP2 9.821 17.1707 3.2245 6.1626
KE-39 CTRP2 9.8402 11.9308 5.3761 0.1163
SNU-685 CTRP2 7.2802 9.5071 5.2022 1.7478
SNG-M CTRP2 7.9999 11.1693 4.8697 2.2038
SNU-1077 CTRP2 8.6513 13.7898 4.0682 4.4114
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP CTRP2 6.7779 8.1478 4.5932 0.2678
TT2609-C02 CTRP2 7.4001 10.4393 4.8478 2.9362
ML-1 [Human leukemia] CTRP2 7.4227 11.9336 4.1542 5.6411
FTC-133 CTRP2 7.4734 8.8636 5.5736 0.4191
CGTH-W-1 CTRP2 7.5091 8.709 4.6629 0.0425
CAL-62 CTRP2 7.7142 9.2546 5.5268 0.4127
BHT-101 CTRP2 7.7969 9.5974 5.4295 0.608
FTC-238 CTRP2 7.9473 11.4988 4.6924 2.892
8505C CTRP2 8.0833 10.4392 5.224 0.9942
TT CTRP2 8.2315 13.9932 3.7115 6.2759
8305C CTRP2 10.5904 26.4531 -1.4655 16.3132
SW579 CTRP2 10.8466 19.654 2.7026 6.8531
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-33 CTRP2 5.7624 8.5032 4.5727 6.7525
SNU-1214 CTRP2 6.0624 10.1456 3.2844 6.0483
BICR 16 CTRP2 6.1299 9.2808 4.4969 6.3414
Detroit 562 CTRP2 6.9308 20.1616 -0.2898 22.1972
BHY CTRP2 7.3412 9.7591 4.2154 0.9185
HSC-2 CTRP2 7.3419 8.9338 5.4841 0.7447
YD-10B CTRP2 7.5304 10.7361 4.7909 2.9967
CAL-27 CTRP2 7.5628 9.082 5.5277 0.4859
SCC-9 CTRP2 7.5915 11.9173 4.2756 4.9225
SCC-4 CTRP2 7.6101 9.4221 5.4132 0.7668
HSC-4 CTRP2 7.6609 11.2114 4.6516 3.3707
SNU-899 CTRP2 7.7314 9.2235 5.546 0.3623
PE/CA-PJ15 CTRP2 7.8387 9.4942 5.4881 0.4436
SCC-25 CTRP2 7.9257 15.7359 2.663 10.7639
HSC-3 CTRP2 8.0695 9.6285 5.5324 0.2648
BICR 56 CTRP2 8.0776 9.6974 5.5104 0.302
BICR 22 CTRP2 8.0801 9.5168 5.5768 0.1894
PE/CA-PJ49 CTRP2 8.1849 9.3808 5.6618 0.0703
BICR 18 CTRP2 8.1998 13.8522 3.7575 6.14
SNU-1066 CTRP2 8.2917 9.9236 5.5118 0.2345
FaDu CTRP2 8.2957 9.9367 5.5086 0.2384
SNU-46 CTRP2 8.5977 17.9517 2.061 11.956
YD-8 CTRP2 8.6049 10.1398 5.5513 0.1176
PE/CA-PJ34 (clone C12) CTRP2 9.3007 15.8491 3.5166 5.6988
BICR 6 CTRP2 10.0144 18.127 2.9035 7.0779
BICR 31 CTRP2 10.7592 21.3237 1.8852 9.6778
PE/CA-PJ41 (clone D2) CTRP2 10.9709 20.1027 2.5726 7.1564
SNU-1041 CTRP2 11.3941 22.6144 1.6796 9.6039
SNU-1076 CTRP2 14.0599 31.6765 -1.7197 12.9469
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JMSU-1 CTRP2 6.3004 8.336 4.2899 1.5166
253J CTRP2 6.8215 10.2966 4.526 5.0292
KMBC-2 CTRP2 6.8976 8.8605 5.268 1.9376
HT-1197 CTRP2 7.1412 9.2189 5.2512 1.7181
CAL-29 CTRP2 7.2615 9.1752 5.3392 1.282
T24 CTRP2 7.3629 9.1391 5.4086 0.9626
BC-3C CTRP2 7.3993 9.2442 5.3827 1.0159
SW1710 CTRP2 7.3996 10.0054 5.0469 2.1873
RT-112 CTRP2 7.5656 11.1481 4.6215 3.6028
KU-19-19 CTRP2 7.5947 9.2996 5.4556 0.6574
647V CTRP2 7.6064 8.9328 5.6037 0.2916
HT-1376 CTRP2 7.663 10.3206 5.0569 1.8772
639V CTRP2 7.7223 8.6235 5.7567 0.0453
BFTC-905 CTRP2 7.7785 9.0487 5.6295 0.1872
UM-UC-3 CTRP2 7.9334 11.0069 4.9044 2.1473
RT-4 CTRP2 8.1234 9.9865 5.4209 0.4667
253J-BV CTRP2 8.1636 9.5093 5.6103 0.1263
5637 CTRP2 8.2608 12.2123 4.5531 3.0648
U-BLC1 CTRP2 8.518 9.9554 5.5835 0.0982
VM-CUB-1 CTRP2 8.712 14.618 3.7242 5.6214
TCCSUP CTRP2 9.1461 18.2803 2.2784 10.3964
SCaBER CTRP2 9.6225 15.7188 3.7634 4.4733
UM-UC-1 CTRP2 9.6533 20.9541 1.3405 12.8904
J82 CTRP2 12.9316 26.3992 0.8726 10.3634
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.4582 8.5243 5.6951 0.1708

References

1 Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52.