Details of the Drug

General Information of Drug (ID: DMLV1ET)

• Drug Name: BIIB074
• Synonyms: CNV1014082; BC600719; HY-12796; B5927; (5R)-5-(4-[2-

Indication

Disease Entry	ICD 11	Status	REF
Bipolar disorder	6A60	Phase 2	[1]
Lumbosacral radiculopathy	8B93.Y	Phase 2	[2]
Trigeminal neuralgia	8B82.0	Phase 2	[2]

• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 314.4
  Logarithm of the Partition Coefficient (xlogp); 2.4
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C18H19FN2O2
  IUPAC Name: (2S,5R)-5-[4-[(2-fluorophenyl)methoxy]phenyl]pyrrolidine-2-carboxamide
  Canonical SMILES: C1C[C@H](N[C@H]1C2=CC=C(C=C2)OCC3=CC=CC=C3F)C(=O)N
  InChI: InChI=1S/C18H19FN2O2/c19-15-4-2-1-3-13(15)11-23-14-7-5-12(6-8-14)16-9-10-17(21-16)18(20)22/h1-8,16-17,21H,9-11H2,(H2,20,22)/t16-,17+/m1/s1
  InChIKey: JESCETIFNOFKEU-SJORKVTESA-N
• Cross-matching ID:
  PubChem CID: 16046068
  CAS Number: 934240-30-9
  UNII: QQS4J85K6Y
  DrugBank ID: DB11706
  TTD ID: D0OX9F
  VARIDT ID: DR01050
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)	TT4G2JS	SCN9A_HUMAN	Inhibitor	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Bipolar disorder
• ICD Disease Classification: 6A60

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated sodium channel alpha Nav1.7 (SCN9A)	DTT	SCN9A	1.42E-03	-0.12	-0.36

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027679)
• [2] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.