Details of the Drug

General Information of Drug (ID: DMLYP2N)

Drug Name

AMG 757

Indication

Disease Entry	ICD 11	Status	REF
Neuroendocrine cancer	2B72.1	Phase 1	[1]
Small-cell lung cancer	2C25.Y	Phase 1	[2]
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Drug Type

Antibody

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Delta-like protein 3 (DLL3)	TT1C9K6	DLL3_HUMAN	Inhibitor	[3]
T-cell surface glycoprotein CD3 (CD3)	TTUN7MC	NOUNIPROTAC	Inhibitor	[3]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04702737) A Study of AMG 757 in Participants With Neuroendocrine Prostate Cancer. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of Amgen.