Details of the Drug

General Information of Drug (ID: DMME09C)

• Drug Name: 1H-Imidazo[4,5-c]quinolin-4-ylamine HCl
• Synonyms: 3H-imidazo[4,5-c]quinolin-4-amine; 1H-Imidazo[4,5-c]quinolin-4-amine; CHEMBL19191; 4-amino-1h-imidazo[4,5-c]quinoline; 132207-04-6; SCHEMBL482926; SCHEMBL212131; imidazo[4,5-c]quinolin-4-amine; imidazo(4,5-c)quinolin 4-amine; WUUCVVFSWNXYRD-UHFFFAOYSA-N; HQBUPOAKJGJGCD-UHFFFAOYSA-N; CS-B1117; BDBM50011593; ZINC28222586; AKOS027322300; 1h-imidazo-[4,5-c]quinolin-4-amine; SB22857; 1H-Imidazo[4,5-c]quinolin-4-ylamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 184.2
  Logarithm of the Partition Coefficient (xlogp); 1.4
  Rotatable Bond Count (rotbonds); 0
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C10H8N4
  IUPAC Name: 3H-imidazo[4,5-c]quinolin-4-amine
  Canonical SMILES: C1=CC=C2C(=C1)C3=C(C(=N2)N)NC=N3
  InChI: InChI=1S/C10H8N4/c11-10-9-8(12-5-13-9)6-3-1-2-4-7(6)14-10/h1-5H,(H2,11,14)(H,12,13)
  InChIKey: HQBUPOAKJGJGCD-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 14896613
  TTD ID: D08MRB

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[1]
Adenosine A2a receptor (ADORA2A)	TTM2AOE	AA2AR_HUMAN	Inhibitor	[1]
Adenosine A2b receptor (ADORA2B)	TTNE7KG	AA2BR_HUMAN	Inhibitor	[1]

References

• [1] 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6.