Details of the Drug

General Information of Drug (ID: DMMW72C)

Drug Name
AZD-1152-HQPA
Synonyms Barasertib
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 507.6
Logarithm of the Partition Coefficient (xlogp) 3
Rotatable Bond Count (rotbonds) 13
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C26H30FN7O3
IUPAC Name
2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide
Canonical SMILES
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
InChI
InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChIKey
QYZOGCMHVIGURT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
16007391
ChEBI ID
CHEBI:91367
CAS Number
722544-51-6
UNII
16XC2U7W8N
DrugBank ID
DB11747
TTD ID
D0Q7RE
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aurora kinase B (AURKB) TT5LS6T AURKB_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aurora kinase B (AURKB) DTT AURKB 3.52E-36 -0.82 -1.62
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 145 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -3.6457 4.2002 -4.0903 61.2483
MEC1 CTRP2 5.7346 10.3137 3.6463 10.6824
JM1 CTRP2 -10.6103 13.3408 -14.5396 69.1961
Mino CTRP2 -13.1948 0.2775 -13.7049 85.1251
ST486 CTRP2 -10.4301 3.0883 -11.2224 78.9012
HL-60 CTRP2 -10.4144 17.072 -15.7879 66.7258
EoL-1 CTRP2 -9.3964 -4.7893 -9.3991 91.6872
KO52 CTRP2 -8.3548 18.1129 -14.0555 63.528
Granta-519 CTRP2 -8.0226 22.4952 -15.6067 61.3363
OCI-AML-3 CTRP2 -7.8443 12.7699 -11.3633 65.6432
GA-10 CTRP2 -7.7858 6.0896 -9.0612 71.1873
TALL-1 [Human adult T-ALL] CTRP2 -7.2339 5.5645 -8.3184 70.6861
SU-DHL-8 CTRP2 -7.1113 -3.3004 -7.1131 84.2411
ALL-SIL CTRP2 -6.3642 -5.5851 -6.3642 82.6663
MOLT-16 CTRP2 -6.3517 -4.4869 -6.3517 82.3308
BV-173 CTRP2 -6.0546 -4.2464 -6.0546 80.4482
RPMI-8402 CTRP2 -6.0469 10.1322 -8.4566 63.9973
DoHH2 CTRP2 -6.0403 -0.6911 -6.074 76.3589
Reh CTRP2 -6.0169 -4.3828 -6.0169 80.2611
SUP-B15 CTRP2 -5.6647 -3.812 -5.6647 77.8965
MOLM-13 CTRP2 -5.6412 -3.3763 -5.6412 77.5835
P12-Ichikawa CTRP2 -5.631 -4.9648 -5.631 77.7833
MV4-11 CTRP2 -5.6202 -4.6772 -5.6202 77.7098
KE-37 CTRP2 -5.6032 -3.1843 -5.6033 77.2603
Peer CTRP2 -5.6021 -3.7348 -5.6021 77.4837
P31/FUJ CTRP2 -5.5673 -5.0097 -5.5673 77.3587
NALM-6 CTRP2 -5.5634 -3.8889 -5.5634 77.2745
OCI-AML-5 CTRP2 -5.5491 -5.0749 -5.5491 77.2374
MOLM-16 CTRP2 -5.5435 -1.9698 -5.5461 75.9621
OCI-Ly19 CTRP2 -5.4713 0.4884 -5.5479 72.5758
SUP-M2 CTRP2 -5.4577 -4.549 -5.4577 76.6283
EM-2 CTRP2 -5.4317 -4.3321 -5.4317 76.4523
SEM CTRP2 -5.4072 -4.8537 -5.4072 76.2924
SU-DHL-10 CTRP2 -5.399 -1.8175 -5.4019 75.0934
Karpas-422 CTRP2 -5.2299 36.6528 -19.4362 54.8654
SU-DHL-6 CTRP2 -5.2213 8.3018 -6.9332 63.3349
OCI-AML-2 CTRP2 -5.1962 -4.2485 -5.1962 74.8863
MHH-CALL-4 CTRP2 -4.9701 -0.6499 -4.9846 71.8154
SUP-T11 CTRP2 -4.717 11.204 -7.424 60.1951
MOLM-6 CTRP2 -4.7169 2.3397 -4.9346 67.3784
MOLT-13 CTRP2 -3.9748 -0.3755 -3.9821 66.2671
NCO2 CTRP2 -3.5316 2.1867 -3.6597 62.203
NB4 CTRP2 -2.8061 3.5928 -3.0724 57.6611
Kasumi-1 CTRP2 -2.4886 1.9737 -2.5485 56.5029
NOMO-1 CTRP2 -2.4565 8.8003 -4.1086 54.1355
JVM-3 CTRP2 -1.8959 10.0836 -3.9822 51.7301
A4/Fukuda CTRP2 -1.8689 8.1036 -3.2303 51.8451
GDM-1 CTRP2 -1.8242 6.0324 -2.5395 51.892
PF-382 CTRP2 -1.2398 6.8208 -2.1299 48.8653
CMK CTRP2 -1.1004 0.9014 -1.1011 47.6006
KMS-27 CTRP2 -1.0752 32.5376 -13.5198 49.3823
U-937 CTRP2 -0.9597 21.2202 -7.9531 48.8135
Daudi CTRP2 -0.9174 18.8899 -6.8163 48.575
AML-193 CTRP2 -0.5608 159.0762 -76.0432 49.6906
KMS-26 CTRP2 -0.5252 8.7022 -1.9933 45.5646
MHH-CALL-3 CTRP2 -0.2526 59.4096 -26.0518 48.8949
JeKo-1 CTRP2 -0.2069 42.1253 -17.4382 48.3939
KHM-1B CTRP2 -0.0691 16.4163 -4.8271 45.7243
Kasumi-2 CTRP2 0.1975 8.3952 -1.1036 41.6174
MOTN-1 CTRP2 0.2293 12.0068 -2.5384 43.2306
RCH-ACV CTRP2 0.6155 12.3993 -2.3141 41.7088
Ri-1 CTRP2 0.656 23.1835 -7.3457 45.0728
BL-70 CTRP2 0.6733 88.4887 -39.735 48.6694
Pfeiffer CTRP2 1.3085 5.5021 1.0134 32.5139
JURL-MK1 CTRP2 1.3523 9.8321 -0.4445 36.2195
KMS-21-BM CTRP2 1.6409 10.7225 -0.5259 35.4516
JJN-3 CTRP2 2.0235 15.0234 -2.1177 37.2318
Ku812 CTRP2 2.1295 10.6865 -0.0094 32.7122
SU-DHL-4 CTRP2 2.1988 15.9254 -2.3784 37.1562
CML-T1 CTRP2 2.2218 8.1366 1.1603 29.0702
HuT 78 CTRP2 2.2437 10.2779 0.2877 31.5874
KMS-28BM CTRP2 2.3589 17.1264 -2.8039 37.3581
RPMI-6666 CTRP2 2.6029 34.0792 -10.9351 43.1095
KMS-12-BM CTRP2 2.7272 15.5175 -1.6776 34.6019
Mono-Mac-1 CTRP2 2.7733 15.6688 -1.7068 34.5352
HPB-ALL CTRP2 2.8135 18.4687 -3.03 36.5599
RPMI-8226 CTRP2 3.0053 8.457 1.8585 24.3724
KM-H2 CTRP2 3.6137 11.4649 1.1138 25.2544
SUP-T1 CTRP2 3.7615 7.3678 3.0985 17.6344
Ki-JK CTRP2 3.7623 12.8273 0.6037 26.4628
PL21 CTRP2 3.7788 24.1641 -4.9665 36.9003
L-363 CTRP2 3.7945 13.3156 0.3978 26.9864
L-540 CTRP2 4.0862 12.2321 1.1981 23.7742
KYO-1 CTRP2 4.1372 12.423 1.1534 23.7956
THP-1 CTRP2 4.1434 6.5625 3.8083 13.8656
Hs 611.T CTRP2 4.3013 19.5493 -2.2106 31.8426
DND-41 CTRP2 4.3609 9.0792 2.9678 16.5673
SKM-1 CTRP2 4.3721 6.3365 4.132 11.9946
DEL CTRP2 4.5813 6.2087 4.3999 10.3886
KMS-34 CTRP2 4.775 19.4714 -1.7543 29.9418
Jurkat CTRP2 4.8386 7.2194 4.2913 10.0841
WSU-DLCL2 CTRP2 5.139 11.8637 2.3496 17.1689
HT CTRP2 5.1621 10.3691 3.1089 14.1138
LAMA-84 CTRP2 5.2039 13.7571 1.467 20.2545
DB CTRP2 5.2212 10.8559 2.9223 14.736
CA46 CTRP2 5.3063 8.9846 3.9215 10.4561
RL CTRP2 5.4508 8.3485 4.3668 8.2875
K-562 CTRP2 5.4959 6.688 5.1993 4.7757
Raji CTRP2 5.537 12.6659 2.3019 16.4926
LP-1 CTRP2 5.6162 6.6223 5.3509 3.8625
OPM-2 CTRP2 5.6353 7.2817 5.0587 5.0066
AMO1 CTRP2 5.6967 10.7314 3.4052 11.7578
Karpas-299 CTRP2 5.8719 7.5474 5.1447 4.1286
Namalwa CTRP2 5.8975 8.0564 4.9135 5.045
HDLM-2 CTRP2 6.1607 8.5242 4.9 4.5902
Ci-1 CTRP2 6.1941 7.3646 5.5046 1.9961
OCI-M1 CTRP2 6.4013 7.9586 5.366 2.232
SR CTRP2 6.4363 8.3673 5.1911 2.8974
KE-97 CTRP2 6.51 16.0653 1.4165 17.7589
M-07e CTRP2 6.5251 21.3965 -1.2349 25.3274
EJM CTRP2 6.5407 9.0627 4.9262 3.8247
KMS-11 CTRP2 6.5628 18.3002 0.3429 21.0899
EHEB CTRP2 6.6434 20.1558 -0.5186 23.3365
Mono-Mac-6 CTRP2 6.6452 23.166 -2.0211 26.8421
TF-1 CTRP2 6.7018 10.3615 4.4062 5.7153
OCI-Ly10 CTRP2 6.7471 21.1116 -0.9119 24.142
HD-MY-Z CTRP2 6.9335 8.4858 5.4609 1.1767
OCI-Ly3 CTRP2 7.0392 12.6149 3.5469 8.6966
HuNS1 CTRP2 7.0476 19.7625 0.0024 21.1762
KMS-18 CTRP2 7.1285 12.3402 3.7479 7.7334
MOLP-2 CTRP2 7.2418 10.0227 4.9426 2.7659
SUP-HD1 CTRP2 7.2556 16.6868 1.6958 15.4244
U266B1 CTRP2 7.2656 16.3057 1.8926 14.7068
KCL-22 CTRP2 7.3393 21.1993 -0.4828 21.9817
MC116 CTRP2 7.4301 8.3517 5.746 0.1009
MM1.S CTRP2 7.4906 24.314 -1.9149 25.1426
SET-2 CTRP2 7.497 8.8579 5.5861 0.3776
HEL 92.1.7 CTRP2 7.5274 8.6117 5.6903 0.159
A3/Kawakami CTRP2 7.594 8.7078 5.6813 0.1552
F-36P CTRP2 7.6236 20.422 0.1256 19.8067
SU-DHL-1 CTRP2 7.6375 19.8561 0.4171 18.9263
NU-DHL-1 CTRP2 7.7306 17.2522 1.7762 14.3312
L-1236 CTRP2 7.7446 11.4313 4.6015 3.4613
KMS-20 CTRP2 7.8217 22.5117 -0.759 21.8685
SIG-M5 CTRP2 7.9014 32.6236 -5.7311 30.9169
Karpas-620 CTRP2 8.0267 9.3 5.6333 0.1242
Toledo CTRP2 8.3962 10.0329 5.5124 0.2067
REC-1 CTRP2 8.4819 10.6504 5.3194 0.534
MOLP-8 CTRP2 8.6978 39.9883 -8.7701 33.2281
P3HR-1 CTRP2 8.9096 20.802 0.8957 15.3958
KMM-1 CTRP2 8.9124 11.008 5.36 0.3066
ME1 CTRP2 8.9955 18.6739 1.9877 11.6339
NCI-H929 CTRP2 9.2477 23.3483 -0.105 17.8503
L-428 CTRP2 10.5588 22.833 1.0485 12.605
HEL CTRP2 10.674 23.267 0.9183 12.8572
⏷ Show the Full List of 145 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 6.1864 9.9048 4.2312 7.3501
EC-GI-10 CTRP2 3.6599 17.9489 -1.9957 32.8884
KYSE-410 CTRP2 5.1169 7.3245 4.5293 8.4185
TE-5 CTRP2 5.9884 6.9438 5.5472 2.2005
OE21 CTRP2 6.0599 7.2056 5.4766 2.3569
TE-11 CTRP2 6.1423 14.8551 1.7203 17.4089
KYSE-70 CTRP2 6.3832 11.7646 3.4615 10.1895
OE19 CTRP2 6.4716 13.5972 2.6179 13.4149
TE-9 CTRP2 6.7306 16.6289 1.3126 17.6973
KYSE-450 CTRP2 6.744 8.1775 5.4892 1.279
KYSE-140 CTRP2 6.7522 19.6283 -0.1671 22.1911
TE-10 CTRP2 6.8751 12.4772 3.4913 9.197
OE33 CTRP2 6.935 10.3148 4.5982 4.5599
TE-1 CTRP2 7.0269 10.6274 4.5111 4.7771
TE-14 CTRP2 7.06 8.8092 5.3886 1.306
COLO 680N CTRP2 7.0941 10.0253 4.8461 3.3345
KYSE-510 CTRP2 7.1084 9.6967 5.0105 2.6699
KYSE-520 CTRP2 8.2269 10.1933 5.3858 0.499
KYSE-30 CTRP2 10.8517 17.8171 3.517 4.1501
KYSE-180 CTRP2 11.0935 25.1738 0.2895 14.1776
KYSE-150 CTRP2 11.4274 21.8425 2.0527 8.3722
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.7147 10.3643 5.0664 1.7944
HuP-T4 CTRP2 2.7438 11.1309 0.4113 29.7709
QGP-1 CTRP2 3.2131 12.7969 0.0927 29.349
KP-4 CTRP2 4.837 17.0894 -0.514 26.9887
MIA PaCa-2 CTRP2 5.4067 11.5539 2.7417 15.0552
HPAC CTRP2 5.7089 7.6888 4.9282 5.3824
SW1990 CTRP2 6.0762 7.413 5.3864 2.7048
PaTu 8988s CTRP2 6.0824 8.4266 4.8848 4.8011
PSN1 CTRP2 6.2243 7.3975 5.5113 1.9167
L3.3 CTRP2 6.2486 8.2891 5.0873 3.6458
PaTu 8902 CTRP2 6.3104 7.9845 5.2861 2.7095
Panc 10.05 CTRP2 6.407 12.8617 2.933 12.291
PaTu 8988t CTRP2 6.4965 7.9892 5.4181 1.8771
BxPC-3 CTRP2 6.5125 18.3316 0.2864 21.3524
TCC-Pan2 CTRP2 6.5876 10.5451 4.2292 6.6414
Hs 766T CTRP2 6.6227 9.4923 4.7755 4.3159
YAPC CTRP2 6.8968 9.7689 4.8357 3.6517
Capan-1 CTRP2 6.913 8.6056 5.3948 1.4398
Panc 05.04 CTRP2 6.9852 11.4459 4.082 6.5954
KP-2 CTRP2 7.1133 8.2343 5.6603 0.3944
Capan-2 CTRP2 7.2948 11.3787 4.3337 5.1033
Panc 08.13 CTRP2 7.4029 17.6892 1.3118 16.4891
AsPC-1 CTRP2 7.4788 9.6315 5.2581 1.358
CFPAC-1 CTRP2 7.5946 9.9513 5.1815 1.512
SUIT-2 CTRP2 7.6036 9.1071 5.5359 0.4445
Panc 02.03 CTRP2 7.6589 9.2696 5.4968 0.5121
HuP-T3 CTRP2 7.6986 10.0426 5.1974 1.3672
PANC-1 CTRP2 8.1592 9.7414 5.5264 0.2479
PK-59 CTRP2 8.192 15.8041 2.8178 9.773
SNU-410 CTRP2 8.4262 11.6385 4.8943 1.7438
Panc 04.03 CTRP2 8.6287 10.3499 5.4871 0.1892
HPAF-II CTRP2 8.65 16.9863 2.5631 10.0604
Panc 03.27 CTRP2 9.159 18.5651 2.1509 10.8301
KP-3 CTRP2 10.6449 22.54 1.2432 11.8861
DAN-G CTRP2 13.4795 43.5184 -6.9158 25.5703
SNU-213 CTRP2 13.6124 50.0227 -10.0007 29.0015
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 6.6655 17.8096 0.6711 19.9
Hs 940.T CTRP2 5.1328 6.3224 4.9619 6.6872
A2058 CTRP2 5.4392 5.964 5.404 4.1536
Mel Ho CTRP2 5.4401 18.5307 -0.7092 26.1884
RPMI-7951 CTRP2 5.6042 8.7142 4.327 8.1156
IGR-1 CTRP2 5.7176 7.0575 5.2451 4.0487
A101D CTRP2 5.8446 6.3815 5.6899 1.9265
Hs 852.T CTRP2 5.8991 17.971 -0.0405 23.4906
SK-MEL-3 CTRP2 5.9387 11.8871 3.0345 12.7842
Hs 934.T CTRP2 6.0032 6.8519 5.6059 1.9243
WM1799 CTRP2 6.0582 11.3212 3.4175 10.9851
COLO 792 CTRP2 6.0943 9.0175 4.5992 5.9788
COLO 800 CTRP2 6.1208 7.3743 5.442 2.3884
WM88 CTRP2 6.4429 8.2334 5.2616 2.5964
WM115 CTRP2 6.4507 8.6156 5.0797 3.3351
Hs 688(A).T CTRP2 6.5572 10.0268 4.4628 5.7211
HT-144 CTRP2 6.6893 8.0971 5.4928 1.3295
IPC-298 CTRP2 6.7149 8.84 5.1582 2.6125
LOX-IMVI CTRP2 6.7202 9.466 4.8589 3.8202
IGR-39 CTRP2 6.7556 8.7322 5.237 2.2415
WT2-iPS CTRP2 6.792 8.9694 5.1482 2.5449
MeWo CTRP2 6.845 8.5816 5.3647 1.6313
IGR-37 CTRP2 6.9296 8.1604 5.6012 0.6988
A-375 CTRP2 6.94 9.0987 5.1835 2.2109
K029AX CTRP2 6.9748 8.9167 5.2897 1.7625
HMCB CTRP2 6.984 10.4194 4.5819 4.553
CJM [Human melanoma] CTRP2 7.097 11.7213 4.0282 6.6395
SK-MEL-28 CTRP2 7.1774 8.3769 5.6328 0.4299
WM983B CTRP2 7.2494 12.8135 3.604 8.125
Mel JuSo CTRP2 7.2809 12.1521 3.9497 6.676
SK-MEL-5 CTRP2 7.281 10.5515 4.7193 3.5861
Hs 895.T CTRP2 7.444 10.639 4.7824 3.1336
RVH-421 CTRP2 7.4535 17.8421 1.2748 16.5254
SK-MEL-30 CTRP2 7.4789 16.4738 1.9716 14.0555
UACC-62 CTRP2 7.52 8.7247 5.6461 0.2396
UACC-257 CTRP2 7.5602 9.252 5.4587 0.6706
SK-MEL-1 CTRP2 7.5898 8.7618 5.6602 0.1908
SK-MEL-2 CTRP2 7.5902 8.6169 5.712 0.1119
SK-MEL-24 CTRP2 7.7248 11.1097 4.7374 2.9724
WM793 CTRP2 8.0987 16.1494 2.5847 10.793
Hs 944.T CTRP2 8.1922 22.0822 -0.2625 19.9406
G-361 CTRP2 8.5428 17.046 2.4609 10.591
WM266-4 CTRP2 8.5643 16.1595 2.9015 8.9216
Hs 839.T CTRP2 9.5275 18.952 2.2115 10.1174
Hs 294T CTRP2 9.8464 18.9445 2.4206 8.975
MDA-MB-435S CTRP2 10.4453 22.1961 1.2758 12.0382
COLO 829 CTRP2 12.7421 32.272 -1.9952 17.904
SK-MEL-31 CTRP2 13.4531 31.2614 -1.0542 14.9078
Hs 936.T CTRP2 15.1682 33.9073 -1.2174 13.501
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 5.7171 7.271 5.1408 4.4809
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 CTRP2 -6.4584 7.7313 -8.0956 66.8185
IMR-32 CTRP2 -6.2868 -3.9214 -6.2868 81.58
CHP-126 CTRP2 -6.1145 2.2026 -6.4077 72.2701
NH-6 CTRP2 -5.966 9.9402 -8.301 63.9524
MHH-NB-11 CTRP2 -0.863 0.8916 -0.8633 46.019
Kelly CTRP2 -0.3325 3.0219 -0.3786 42.603
SK-N-DZ CTRP2 -0.1427 13.9351 -3.77 45.3861
KP-N-SI9s CTRP2 0.132 39.0292 -15.6018 47.7853
SK-N-FI CTRP2 1.7148 7.1043 0.9927 31.2175
SK-N-BE(2) CTRP2 2.4954 15.0161 -1.6584 35.1804
SiMa CTRP2 2.756 9.0428 1.3516 26.8401
SK-N-SH CTRP2 3.0757 9.2342 1.5992 25.0838
NB1 CTRP2 3.888 24.0959 -4.8359 36.5393
SK-N-AS CTRP2 6.9901 23.6048 -1.9607 26.1027
KP-N-YN CTRP2 8.454 10.2742 5.4479 0.2931
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-245 CTRP2 5.2676 19.2437 -1.2133 27.7434
SNU-478 CTRP2 5.2691 15.3707 0.7204 22.5669
SNU-869 CTRP2 6.5134 9.8379 4.5229 5.545
SNU-1196 CTRP2 6.6521 8.3777 5.3371 1.9844
HuCC-T1 CTRP2 6.7654 11.7198 3.7829 8.1878
HuH-28 CTRP2 7.649 9.5749 5.3693 0.8682
SNU-308 CTRP2 7.7259 16.8193 1.986 13.5909
SNU-1079 CTRP2 8.7557 10.3345 5.5381 0.1088
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 -5.6378 10.014 -7.9732 63.1502
SK-ES-1 CTRP2 -5.4484 -4.7321 -5.4484 76.5663
MHH-ES-1 CTRP2 -3.9024 7.7825 -5.3308 59.7807
A-673 CTRP2 -0.415 21.1739 -7.4027 47.4637
TC71 CTRP2 6.2679 23.2149 -2.3553 28.2013
Hs 888.T CTRP2 6.3871 11.1942 3.7492 8.9929
Hs 822.T CTRP2 6.8272 8.3669 5.4525 1.3216
HOS CTRP2 6.9016 9.0921 5.162 2.3441
MG-63 CTRP2 7.0141 9.9099 4.8478 3.4371
U2OS CTRP2 7.4263 17.5272 1.4101 16.1161
CAL-78 CTRP2 7.5584 16.9944 1.7742 14.6268
SW1353 CTRP2 8.0549 21.856 -0.2547 20.1457
G-292 clone A141B1 CTRP2 8.1459 14.4575 3.4341 7.4678
SaOS-2 CTRP2 8.4008 22.8312 -0.4752 20.1753
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 70 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-468 CTRP2 -7.8224 18.947 -13.8553 62.4005
CAL-148 CTRP2 -5.9807 -4.6397 -5.9807 80.0825
MDA-MB-157 CTRP2 3.0939 24.4696 -5.7294 39.0167
CAL-51 CTRP2 3.8355 16.0113 -0.8815 30.1826
AU565 CTRP2 5.1905 7.2133 4.6539 7.733
CAL-85-1 CTRP2 5.4562 9.5963 3.7573 10.8066
DU4475 CTRP2 5.6194 6.2247 5.5213 3.1873
ZR-75-30 CTRP2 5.6529 10.3383 3.5631 11.1959
BT-474 CTRP2 5.9259 8.1083 4.9121 4.993
HCC1428 CTRP2 6.0054 6.7874 5.6399 1.7769
SK-BR-3 CTRP2 6.1253 8.4323 4.9172 4.584
HCC1143 CTRP2 6.1572 16.7838 0.7684 20.5774
HCC1419 CTRP2 6.2184 7.5084 5.4519 2.1741
MDA-MB-453 CTRP2 6.254 9.0032 4.7359 5.1087
EFM-192A CTRP2 6.3838 8.2747 5.198 2.954
CAL-120 CTRP2 6.5445 8.7286 5.0928 3.1317
ZR-75-1 CTRP2 6.6118 8.8763 5.0689 3.1263
HCC38 CTRP2 6.7284 8.629 5.268 2.1551
HCC1937 CTRP2 6.7868 11.5236 3.8962 7.6843
T-47D CTRP2 6.8102 8.8916 5.1973 2.3254
HCC1806 CTRP2 6.8545 11.4535 3.9817 7.2192
MDA-MB-231 CTRP2 6.9325 12.4212 3.5625 8.81
HDQ-P1 CTRP2 7.032 18.8121 0.4638 19.8565
MDA-MB-361 CTRP2 7.2245 10.4768 4.7177 3.6678
HCC1954 CTRP2 7.2259 19.319 0.3642 19.8055
HCC1395 CTRP2 7.2967 11.3829 4.333 5.1036
BT-549 CTRP2 7.481 9.4261 5.3475 1.0623
Hs 578Bst CTRP2 7.5876 9.8502 5.2216 1.3835
HCC2218 CTRP2 7.598 10.3069 5.0264 2.0506
CAMA-1 CTRP2 7.7084 13.5156 3.5882 7.4883
MDA-MB-415 CTRP2 8.2039 9.9325 5.4742 0.3263
HMC-1-8 CTRP2 8.4564 16.7073 2.5647 10.3341
JIMT-1 CTRP2 8.4958 9.9024 5.5937 0.0917
HCC1500 CTRP2 8.5649 23.222 -0.545 20.0977
MCF-7 CTRP2 8.6166 24.0414 -0.9107 20.9568
BT-20 CTRP2 9.2956 18.1953 2.4179 9.6961
BT 231 CTRP2 2.1271 10.4439 0.0952 32.4525
BT 145 CTRP2 2.2063 33.0356 -10.7696 43.6514
BT 271 CTRP2 3.4775 13.4439 0.0357 28.8059
BT 482 CTRP2 3.8123 12.2547 0.9274 25.3394
BT 245 CTRP2 4.8785 13.618 1.2469 21.7314
BT 428 CTRP2 5.0101 18.4515 -1.0408 27.8886
BT147 CTRP2 5.0579 22.4857 -3.0122 31.6894
BT164 CTRP2 5.6159 15.9617 0.7243 21.8167
BT 112 CTRP2 5.7469 19.783 -1.0743 26.4476
BT 286 CTRP2 5.979 26.9734 -4.4746 32.2452
BT 216 CTRP2 6.1315 14.2904 1.9938 16.438
BT 440 CTRP2 6.3969 13.9632 2.3747 14.4945
BT 172 CTRP2 6.4751 23.694 -2.4241 27.9597
BT 248 CTRP2 6.4774 20.665 -0.9083 24.6343
BT 359 CTRP2 6.573 10.2049 4.3866 6.0116
BT 320 CTRP2 6.6999 8.2019 5.4507 1.4778
BT 328 CTRP2 6.7772 11.6374 3.8327 7.9627
BT 228 CTRP2 6.8673 14.2808 2.5902 12.8016
BT 422 CTRP2 6.9746 11.7608 3.9195 7.2793
BT 224 CTRP2 6.976 9.6948 4.925 3.1817
BT 179 CTRP2 6.9773 8.6575 5.4091 1.3178
BT 416 CTRP2 6.9981 16.1463 1.7646 15.6378
BT 239 CTRP2 7.0423 23.237 -1.7351 25.5249
BT 131 CTRP2 7.1489 24.3908 -2.2254 26.3775
BT 504 CTRP2 7.5142 27.8757 -3.6719 28.4556
BT 187 CTRP2 7.7295 16.4792 2.1561 12.9674
BT 330 CTRP2 8.2378 23.9812 -1.1681 22.1971
BT 159 CTRP2 8.8816 17.3423 2.5492 9.7857
BT 498 CTRP2 9.3672 21.0125 1.116 14.0196
BT 139 CTRP2 10.7062 24.9336 0.1456 15.0898
BT 232 CTRP2 10.921 24.9786 0.2681 14.4605
BT 444 CTRP2 11.2495 24.2933 0.8075 12.4683
BT 333 CTRP2 11.7928 28.213 -0.6929 15.9532
BT 340 CTRP2 15.0049 31.6883 -0.3037 11.4449
⏷ Show the Full List of 70 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 6.1984 7.7256 5.3284 2.725
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 0.5626 14.0034 -3.0881 42.6797
LN-229 CTRP2 4.7443 7.1764 4.2117 10.6466
42-MG-BA CTRP2 5.0646 13.0076 1.7159 19.6862
GaMG CTRP2 6.12 7.999 5.1293 3.703
SF539 CTRP2 6.3856 14.0366 2.3289 14.6905
DK-MG CTRP2 6.3984 7.8153 5.4338 1.9587
SNU-466 CTRP2 6.4223 7.9205 5.3996 2.0619
SF295 CTRP2 6.4236 14.744 2.0065 15.8253
YKG-1 CTRP2 6.4246 25.4232 -3.33 29.6985
GMS-10 CTRP2 6.8054 8.0203 5.5954 0.8293
SF268 CTRP2 6.9221 10.6348 4.4332 5.2536
KG-1-C CTRP2 6.923 8.9695 5.2332 2.0403
Hs 683 CTRP2 6.9809 16.253 1.698 15.905
M059K CTRP2 7.0849 15.053 2.3751 13.2408
8-MG-BA CTRP2 7.1102 9.3044 5.1938 1.9666
SNU-201 CTRP2 7.146 9.408 5.1679 2.0225
SNU-1105 CTRP2 7.156 12.5898 3.6456 8.1054
AM-38 CTRP2 7.1604 14.6694 2.6229 12.164
Becker CTRP2 7.2341 9.6782 5.0972 2.1863
NMC-G1 CTRP2 7.2645 9.4743 5.208 1.7436
T98G CTRP2 7.2669 10.5776 4.6978 3.6897
U-87MG ATCC CTRP2 7.3503 10.7232 4.6832 3.6369
CCF-STTG1 CTRP2 7.3683 9.9951 5.0329 2.274
SNU-738 CTRP2 7.6507 9.0309 5.5851 0.3125
SNU-489 CTRP2 7.6581 9.2363 5.5095 0.481
SNU-626 CTRP2 7.6832 15.7015 2.5042 11.748
TM-31 CTRP2 7.8396 9.0468 5.6532 0.1368
LN-18 CTRP2 7.9884 13.7646 3.6595 6.8075
YH-13 CTRP2 8.3751 34.748 -6.4143 31.1092
SW1783 CTRP2 8.4423 10.5537 5.3395 0.5074
SF126 CTRP2 8.4465 13.1821 4.2231 4.0696
ONS-76 CTRP2 8.6261 22.3178 -0.0538 18.6638
SNB-75 CTRP2 8.9743 20.3395 1.167 14.4324
SW1088 CTRP2 9.0864 18.6494 2.0614 11.2463
U-251MG CTRP2 9.2686 17.0185 2.9552 7.788
U-118MG CTRP2 9.3617 21.7178 0.7706 15.1124
DBTRG-05MG CTRP2 9.4466 21.8511 0.7655 15.0047
GB-1 CTRP2 9.5331 15.7348 3.7051 4.7694
KNS-42 CTRP2 10.2481 23.878 0.3411 15.1455
A-172 CTRP2 10.2951 26.2869 -0.7904 18.167
GOS-3 CTRP2 10.6937 23.7921 0.682 13.5459
KALS-1 CTRP2 12.3587 34.5176 -3.3352 21.1212
Daoy CTRP2 13.3586 25.9985 1.3021 8.6909
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 -4.8865 4.8981 -5.5924 65.2835
RL95-2 CTRP2 1.9166 17.5285 -3.4182 39.2658
JHUEM-1 CTRP2 4.5668 10.8786 2.3074 18.6422
HEC-59 CTRP2 5.3807 14.9909 1.0067 21.416
AN3-CA CTRP2 5.9517 14.4451 1.7665 17.6236
MFE-296 CTRP2 6.6458 9.7494 4.6661 4.7308
HEC-6 CTRP2 6.967 8.7972 5.3397 1.5841
HEC-151 CTRP2 7.0293 8.6732 5.4317 1.184
HEC-265 CTRP2 7.052 8.8554 5.3633 1.4052
MFE-319 CTRP2 7.3375 8.8386 5.5212 0.6386
HEC-1-A CTRP2 7.5085 10.6604 4.8124 2.9411
EN CTRP2 7.5178 40.2766 -9.8598 35.6599
EFE-184 CTRP2 7.6627 11.2798 4.621 3.4856
HEC-50B CTRP2 7.9509 9.8719 5.3904 0.6233
JHUEM-3 CTRP2 8.1435 10.1094 5.3824 0.545
ESS-1 CTRP2 8.3018 14.6663 3.4385 7.2364
HEC-1-B CTRP2 8.7838 16.9895 2.6521 9.544
HEC-251 CTRP2 9.2727 22.1252 0.5098 16.0362
KLE CTRP2 10.1285 23.6149 0.3859 15.1791
HEC-108 CTRP2 16.3721 35.9182 -1.4159 12.8091
Ishikawa (Heraklio) 02 ER- CTRP2 7.0963 8.157 5.6832 0.3447
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR10TKB CTRP2 5.7398 6.8156 3.7398 0.1262
KMRC-2 CTRP2 7.0274 8.8289 5.361 1.4394
KMRC-1 CTRP2 7.1493 8.5543 5.5467 0.6967
OS-RC-2 CTRP2 7.2258 10.5984 4.6607 3.8916
TUHR4TKB CTRP2 7.9199 9.0252 5.6897 0.0796
UO-31 CTRP2 7.944 11.6612 4.6168 3.1743
RCC10RGB CTRP2 7.956 9.42 5.5639 0.245
BFTC-909 CTRP2 8.0979 19.0635 1.1569 15.8332
SNU-1272 CTRP2 8.1174 9.192 5.7019 0.0467
Caki-2 CTRP2 8.1642 9.4073 5.6456 0.0879
VMRC-RCW CTRP2 8.2908 9.8975 5.5208 0.2206
KMRC-20 CTRP2 8.4033 9.7299 5.6199 0.08
786-O CTRP2 8.5307 10.0424 5.5583 0.1219
ACHN CTRP2 8.6444 10.154 5.5604 0.1029
VMRC-RCZ CTRP2 8.8705 13.8993 4.1472 3.887
TUHR14TKB CTRP2 9.1022 11.3442 5.3119 0.3314
Caki-1 CTRP2 9.1257 10.8678 5.4867 0.1073
CAL-54 CTRP2 10.0866 23.1559 0.578 14.669
769-P CTRP2 11.3484 20.8876 2.4383 7.2037
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 CTRP2 -5.866 -4.2093 -5.866 79.2668
SNU-175 CTRP2 -4.8308 -2.5643 -4.8308 72.3286
COLO205 CTRP2 -3.6055 -1.3934 -3.6056 64.2569
GP2d CTRP2 1.3481 9.9948 -0.5172 36.3896
SK-CO-1 CTRP2 1.4198 19.023 -4.6111 41.6882
SW948 CTRP2 1.7751 4.0559 1.7417 28.5544
HT115 CTRP2 1.7922 11.6709 -0.792 35.5383
CL-11 CTRP2 2.0859 7.9443 1.0894 29.7208
SNU-81 CTRP2 2.5658 17.4123 -2.747 36.7579
NCI-H508 CTRP2 3.1278 12.0033 0.3858 28.7704
LS513 CTRP2 3.6763 8.3748 2.5915 19.8051
CCK-81 CTRP2 4.9459 13.0903 1.5687 20.474
SW1463 CTRP2 5.0719 11.3538 2.5413 16.576
KM12 CTRP2 5.0759 7.006 4.6285 8.1304
SNU-407 CTRP2 5.1524 16.8936 -0.1404 25.3225
SNU-C1 CTRP2 5.9585 7.6663 5.1608 3.8835
T84 CTRP2 6.0556 10.328 3.9119 8.9361
SW620 CTRP2 6.2989 11.4113 3.57 9.8982
HT-29 CTRP2 6.3706 7.7833 5.4295 2.0187
NCI-H716 CTRP2 6.4631 8.3716 5.2086 2.7829
SNU-C5 CTRP2 6.5402 8.7627 5.073 3.2198
C2BBe1 CTRP2 6.6192 8.4092 5.2999 2.1785
OUMS-23 CTRP2 6.6469 7.751 5.6255 0.8821
MDST8 CTRP2 6.7793 8.0754 5.5562 0.9937
HT-55 CTRP2 6.8329 9.9208 4.7176 4.2267
NCI-H747 CTRP2 6.9727 10.5274 4.5215 4.8158
CW-2 CTRP2 7.0042 9.698 4.9422 3.0748
LoVo CTRP2 7.0318 14.3953 2.6606 12.2402
SNU-61 CTRP2 7.0746 15.5462 2.1224 14.2036
DLD-1 CTRP2 7.27 16.6999 1.7004 15.383
RCM-1 [Human ESC] CTRP2 7.2888 8.4729 5.6447 0.3401
LS1034 CTRP2 7.3907 9.0689 5.4521 0.8057
HCC-56 CTRP2 7.4455 8.4114 5.7307 0.1185
LS411N CTRP2 7.4488 9.0293 5.4965 0.636
SNU-C4 CTRP2 7.489 8.5981 5.6803 0.1869
COLO201 CTRP2 7.6241 8.9781 5.594 0.3046
LS123 CTRP2 7.644 9.6866 5.3203 1.0196
HCT 8 CTRP2 7.7762 8.9537 5.6625 0.1382
SW1417 CTRP2 7.8155 9.6655 5.4109 0.6459
COLO 678 CTRP2 8.0344 19.6792 0.806 17.0635
SNU-503 CTRP2 8.2342 30.9398 -4.6287 28.8759
HCT 15 CTRP2 8.2544 9.8378 5.5283 0.2185
HCT 116 CTRP2 8.3189 9.4466 5.6856 0.0404
COLO 320 CTRP2 8.585 10.9507 5.2484 0.6474
RKO CTRP2 8.9775 17.5613 2.5088 9.8001
SNU-C2A CTRP2 9.2876 22.3057 0.4324 16.2448
LS180 CTRP2 10.0565 24.4054 -0.0456 16.5118
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-878 CTRP2 1.2942 8.6487 -0.0267 35.4614
SNU-182 CTRP2 5.0108 9.7269 3.284 13.7438
JHH-5 CTRP2 5.2369 42.9781 -13.0996 40.5185
HuH-6 CTRP2 5.4215 7.3314 4.8291 6.453
Hep 3B2.1-7 CTRP2 5.5834 7.2967 5.0021 5.3604
JHH-1 CTRP2 5.8427 6.4239 5.6683 2.0187
Hep-G2 CTRP2 6.2945 19.1503 -0.3013 23.4236
SK-HEP-1 CTRP2 6.9486 9.5104 4.9947 2.9418
HuH-1 CTRP2 7.2184 9.0374 5.376 1.1959
JHH-4 CTRP2 7.3979 9.1457 5.4236 0.8879
SNU-475 CTRP2 7.557 9.1448 5.5002 0.5599
HLF CTRP2 7.5705 9.0131 5.558 0.4082
SNU-387 CTRP2 7.6611 13.7606 3.4365 8.1607
JHH-6 CTRP2 7.6729 8.4799 5.7876 0.0289
SNU-398 CTRP2 7.9875 25.7357 -2.2325 24.9932
SNU-423 CTRP2 8.4503 10.3177 5.4306 0.3244
PLC/PRF/5 CTRP2 8.7395 10.1649 5.5897 0.0673
JHH-2 CTRP2 8.8944 10.8289 5.417 0.2259
SNU-886 CTRP2 9.5161 23.8052 -0.1353 17.5364
Li-7 CTRP2 11.2044 40.6788 -7.1832 28.459
SNU-449 CTRP2 13.4704 26.1384 1.3032 8.58
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 134 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-LCD CTRP2 -7.6288 25.3988 -16.5087 59.9201
NCI-H2081 CTRP2 -4.9362 12.6372 -8.215 60.0039
NCI-H2141 CTRP2 -2.4265 25.2705 -11.2979 51.8599
HARA [Human squamous cell lung carcinoma] CTRP2 -2.145 6.7423 -3.0928 53.3223
NCI-H446 CTRP2 -1.9762 8.908 -3.6293 52.1957
NCI-H510A CTRP2 -1.7379 8.2336 -3.1333 51.2534
NCI-H2009 CTRP2 -1.0857 5.7171 -1.65 47.909
NCI-H1184 CTRP2 -0.8761 11.6237 -3.5233 47.7497
COR-L47 CTRP2 -0.6893 54.6226 -24.0618 49.2396
NCI-H211 CTRP2 -0.3085 8.0574 -1.5266 44.2198
NCI-H524 CTRP2 0.1729 20.4825 -6.5057 45.8188
DMS 273 CTRP2 0.3055 145.7099 -68.6266 49.3335
LCLC-97TM1 CTRP2 0.3802 16.2431 -4.3015 44.1677
NCI-H841 CTRP2 1.225 42.9451 -16.5616 46.5148
NCI-H2286 CTRP2 2.1679 14.2757 -1.6233 36.014
HCC95 CTRP2 2.2206 10.586 0.1281 32.0821
NCI-H2106 CTRP2 2.242 9.7845 0.5009 31.0023
NCI-H1105 CTRP2 2.363 9.0257 0.9492 29.3033
HCC44 CTRP2 2.7135 10.8939 0.4891 29.637
NCI-H1703 CTRP2 2.874 11.9334 0.1693 30.0703
HCC15 CTRP2 3.1008 13.1605 -0.1891 30.3856
NCI-H69 CTRP2 3.1472 15.7357 -1.3862 32.9647
NCI-H889 CTRP2 3.5344 13.258 0.1794 28.2676
DV-90 CTRP2 3.6361 19.2393 -2.6538 34.0822
HCC1588 CTRP2 3.7335 9.7744 2.0229 21.7861
NCI-H1650 CTRP2 3.7812 12.6555 0.7046 26.11
NCI-H1734 CTRP2 4.0427 13.694 0.4457 26.2285
EPLC-272H CTRP2 4.4004 18.8071 -1.7539 30.7495
NCI-H810 CTRP2 4.4581 8.1555 3.4885 14.2529
NCI-H1341 CTRP2 4.6113 11.4178 2.0865 19.3699
NCI-H1666 CTRP2 4.9341 12.6391 1.7815 19.744
LK2 CTRP2 4.9404 21.913 -2.8277 31.6089
SK-MES-1 CTRP2 5.0401 13.0307 1.6827 19.8596
EBC-1 CTRP2 5.2173 9.3775 3.6467 11.7899
HCC827 CTRP2 5.2221 14.9313 0.8983 22.1081
DMS 79 CTRP2 5.3363 6.7451 5.0102 5.9402
LXF 289 CTRP2 5.4117 17.8448 -0.391 25.4375
NCI-H358 CTRP2 5.4224 18.0698 -0.4942 25.6824
COR-L95 CTRP2 5.485 6.8758 5.1037 5.1852
NCI-H1568 CTRP2 5.5271 9.8557 3.6922 10.9249
NCI-H1581 CTRP2 5.5437 16.5462 0.3706 23.0422
NCI-H526 CTRP2 5.6894 12.1415 2.6952 14.646
HCC2108 CTRP2 5.7117 17.2968 0.1386 23.3671
COR-L51 CTRP2 5.73 6.7437 5.4076 3.3525
NCI-H2029 CTRP2 5.7397 6.3697 5.5891 2.5966
NCI-H2196 CTRP2 5.786 6.6277 5.5169 2.7722
NCI-H1435 CTRP2 5.7868 8.1332 4.7782 5.8414
NCI-H2087 CTRP2 5.8783 15.0427 1.4062 19.039
Lu-65 CTRP2 5.8838 8.6329 4.614 6.3297
NCI-H2085 CTRP2 5.9524 15.8683 1.0556 20.0651
CAL-12T CTRP2 6.0709 8.324 4.9266 4.6475
NCI-H522 CTRP2 6.1026 8.9705 4.6296 5.8356
NCI-H292 CTRP2 6.1049 13.1121 2.5609 14.3386
NCI-H520 CTRP2 6.1535 11.011 3.6515 9.834
NCI-H1944 CTRP2 6.1584 7.9502 5.1847 3.3994
NCI-H1693 CTRP2 6.1986 9.5908 4.398 6.6278
NCI-H2405 CTRP2 6.2431 15.7856 1.3383 18.542
MOR/CPR CTRP2 6.3436 7.3977 5.598 1.3716
NCI-H1092 CTRP2 6.3935 9.3955 4.6501 5.2203
DMS 114 CTRP2 6.413 7.7574 5.4722 1.7797
NCI-H650 CTRP2 6.4428 17.3246 0.7327 20.1318
SK-LU-1 CTRP2 6.4948 11.3876 3.7383 8.844
HCC2935 CTRP2 6.502 8.4704 5.1884 2.8053
NCI-H1694 CTRP2 6.5822 19.1557 -0.0686 22.2366
NCI-H838 CTRP2 6.608 8.06 5.4587 1.5629
NCI-H2126 CTRP2 6.6586 13.4239 2.8532 12.1464
NCI-H1838 CTRP2 6.7933 9.1484 5.0635 2.8821
NCI-H2291 CTRP2 6.8042 13.7481 2.806 12.0719
NCI-H1573 CTRP2 6.8809 13.5041 2.9867 11.2218
HCC78 CTRP2 6.9002 13.6943 2.9071 11.5036
NCI-H1915 CTRP2 6.987 10.8784 4.3608 5.4501
HOP-92 CTRP2 7.0152 13.386 3.148 10.3469
RERF-LC-Ad1 CTRP2 7.0423 8.2049 5.6389 0.4979
COLO 668 CTRP2 7.0653 9.3879 5.1275 2.2718
NCI-H2110 CTRP2 7.1223 10.286 4.7407 3.7153
NCI-H441 CTRP2 7.1336 9.3931 5.1672 2.0393
NCI-H2342 CTRP2 7.1693 8.9285 5.3967 1.1706
DMS 53 CTRP2 7.205 9.2402 5.2787 1.5506
HOP-62 CTRP2 7.2145 11.5476 4.1964 5.7756
NCI-H322 CTRP2 7.2347 10.232 4.84 3.1731
NCI-H647 CTRP2 7.311 11.4991 4.2868 5.269
NCI-H1869 CTRP2 7.3295 9.9232 5.0425 2.282
LCLC-103H CTRP2 7.3753 8.6417 5.6169 0.3637
RERF-LC-Ad2 CTRP2 7.3901 8.77 5.5733 0.4642
HCC4006 CTRP2 7.4256 14.4494 2.93 10.5282
NCI-H1339 CTRP2 7.4498 8.9611 5.5244 0.5585
NCI-H661 CTRP2 7.458 19.7514 0.3304 19.4957
BEN CTRP2 7.4819 8.3894 5.7518 0.0834
NCI-H2172 CTRP2 7.49 10.9851 4.6498 3.5884
EKVX CTRP2 7.5326 16.3033 2.0962 13.5124
NCI-H460 CTRP2 7.533 8.654 5.6772 0.1789
NCI-H23 CTRP2 7.5413 20.7441 -0.0983 20.5838
HCC366 CTRP2 7.575 10.9432 4.7227 3.2032
LC-1/sq-SF CTRP2 7.5855 8.9262 5.5975 0.3129
SHP-77 CTRP2 7.6076 12.7985 3.8647 6.5342
NCI-H727 CTRP2 7.7212 17.1455 1.8218 14.1856
HCC1195 CTRP2 7.7214 25.2476 -2.1979 25.3561
NCI-H2023 CTRP2 7.7373 13.7825 3.4792 7.8777
NCI-H2030 CTRP2 7.7619 13.2985 3.7297 6.8496
DMS 454 CTRP2 7.785 19.9318 0.4925 18.4475
ChaGo-K-1 CTRP2 7.7987 9.7005 5.3892 0.7137
COLO 699 CTRP2 7.8339 20.2579 0.3683 18.7373
NCI-H2122 CTRP2 7.8519 15.8333 2.5624 11.2596
HCC2279 CTRP2 7.8707 14.0735 3.4311 7.8715
NCI-H2170 CTRP2 7.9991 9.9946 5.3636 0.6652
NCI-H1563 CTRP2 8.0151 9.5448 5.5416 0.2658
NCI-H1651 CTRP2 8.0562 9.8717 5.4362 0.4624
NCI-H1755 CTRP2 8.1227 9.9034 5.4521 0.4003
NCI-H1623 CTRP2 8.1807 9.7728 5.5234 0.2467
KNS-62 CTRP2 8.2081 9.5523 5.6115 0.117
T3M-10 CTRP2 8.3381 10.1137 5.4609 0.3062
NCI-H1155 CTRP2 8.4541 16.4575 2.6835 9.8953
LOU-NH91 CTRP2 8.4654 20.4072 0.7672 16.4874
Calu-1 CTRP2 8.4738 12.1417 4.7031 2.3318
NCI-H1395 CTRP2 8.4827 10.6462 5.3213 0.5295
LUDLU-1 CTRP2 8.5408 10.1215 5.5346 0.1469
NCI-H196 CTRP2 8.5687 14.3565 3.7564 5.6746
HCC1171 CTRP2 8.9617 15.4027 3.5154 6.0999
COR-L105 CTRP2 9.1194 15.5174 3.5591 5.7517
SBC-5 CTRP2 9.2154 21.8719 0.5924 15.8725
NCI-H1792 CTRP2 9.3268 17.5823 2.7279 8.5405
RERF-LC-A1 CTRP2 9.3986 20.5552 1.3584 13.19
NCI-H1373 CTRP2 9.4422 18.253 2.4864 9.2583
Calu-6 CTRP2 9.4656 20.3576 1.4993 12.6311
A-549 CTRP2 9.5183 19.8149 1.7948 11.5666
NCI-H1793 CTRP2 9.6705 17.3796 3.0381 6.9992
Calu-3 CTRP2 9.7839 23.0957 0.3982 15.6254
Lu-99 CTRP2 10.8442 27.5841 -1.0352 18.0353
RERF-LC-MS CTRP2 11.078 24.143 0.7676 12.8
NCI-H1299 CTRP2 11.3529 22.0973 1.892 8.9715
HCC1833 CTRP2 11.6201 27.2848 -0.3657 15.3162
NCI-H1355 CTRP2 11.7389 37.878 -5.4121 25.404
HCC1438 CTRP2 14.0551 30.013 -0.1048 11.8755
Hs 888.Lu CTRP2 10.085 20.3837 1.8977 10.4682
⏷ Show the Full List of 134 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 -2.5386 11.618 -5.2694 53.7596
P-STS CTRP2 6.451 10.9484 3.9224 8.1577
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 0.8746 15.0455 -3.2556 41.9118
A2780 CTRP2 -0.7693 18.6938 -6.5788 48.1584
Caov-3 CTRP2 -0.23 74.0986 -33.3432 49.0943
COV434 CTRP2 1.7019 11.8344 -0.9571 36.1486
SNU-119 CTRP2 5.4183 8.6597 4.1843 9.1167
OAW28 CTRP2 6.075 11.3469 3.4186 10.9477
COV362 CTRP2 6.1534 8.7364 4.7882 5.0737
ONCO-DG-1 CTRP2 6.2156 9.5691 4.4226 6.4933
SNU-8 CTRP2 6.3521 7.5912 5.51 1.7173
SNU-840 CTRP2 6.4073 8.966 4.8739 4.2626
Kuramochi CTRP2 6.4232 9.9678 4.3887 6.2611
JHOS-2 CTRP2 6.5783 9.4291 4.7737 4.3947
OVCAR-5 CTRP2 6.6399 9.5608 4.7544 4.3755
FU-OV-1 CTRP2 6.7154 10.1434 4.5237 5.2072
RMG-I CTRP2 6.8258 10.5945 4.3832 5.6102
OC 314 CTRP2 7.0537 10.0456 4.8096 3.535
OVISE CTRP2 7.112 8.7373 5.4491 1.0448
EFO-27 CTRP2 7.144 8.7051 5.4801 0.9131
MCAS CTRP2 7.2184 9.794 5.0342 2.4432
OV-90 CTRP2 7.2483 8.8954 5.4531 0.9133
OVCAR-4 CTRP2 7.3676 11.7699 4.1953 5.5556
OAW42 CTRP2 7.5278 8.6561 5.6743 0.1853
JHOM-1 CTRP2 7.6126 8.9234 5.6097 0.277
OV56 CTRP2 7.6836 8.6417 5.7371 0.0669
OVTOKO CTRP2 7.8123 11.8477 4.4504 3.9565
OVCAR-8 CTRP2 7.9103 13.1603 3.8955 5.9884
IGROV-1 CTRP2 7.9487 16.943 2.0891 12.8568
SK-OV-3 CTRP2 8.0842 14.2072 3.5123 7.2495
OVK18 CTRP2 8.5291 28.0585 -2.9667 25.6015
EFO-21 CTRP2 8.5518 9.8765 5.6218 0.0623
DOV13 CTRP2 8.6102 19.0158 1.5527 13.7041
TYK-nu CTRP2 8.7569 16.1286 3.0441 8.1228
OV7 CTRP2 9.7347 20.1874 1.7614 11.3861
TOV-112D CTRP2 9.9194 24.6701 -0.27 17.3235
HEY A8 CTRP2 10.6142 25.3188 -0.1016 15.9025
ES2 CTRP2 10.9931 20.0384 2.6146 6.9931
COV644 CTRP2 11.9623 29.0054 -0.9577 16.4108
OVSAHO CTRP2 12.275 26.1951 0.567 11.959
JHOC-5 CTRP2 17.6262 32.4576 0.7844 6.5697
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 6.136 13.7479 2.2687 15.4012
Yamato-SS CTRP2 6.6289 10.5609 4.2528 6.4732
G-402 CTRP2 1.6541 10.253 -0.309 34.926
A-204 CTRP2 2.5346 10.8588 0.3248 30.6181
TTC-709 CTRP2 3.441 23.632 -5.0032 37.6088
Rh41 CTRP2 5.1275 8.2037 4.13 10.0106
BT-12 CTRP2 5.157 6.9389 4.7414 7.4718
BT-16 CTRP2 5.9598 15.3408 1.3256 19.149
Rh18 CTRP2 6.009 9.0383 4.5178 6.4851
SW982 CTRP2 6.1887 15.5944 1.3891 18.4756
MES-SA CTRP2 6.5351 11.633 3.6478 9.1463
G-401 CTRP2 6.5936 16.4884 1.2727 18.0891
Hs 729.T CTRP2 6.5999 11.1305 3.9481 7.7885
TE 441.T CTRP2 6.8968 37.7449 -9.1012 35.8502
KYM-1 CTRP2 7.2236 12.3258 3.824 7.274
SK-LMS-1 CTRP2 7.4121 9.7337 5.1763 1.7049
Tm87-16 CTRP2 7.5171 18.421 1.0365 17.2008
RD CTRP2 7.5442 17.3243 1.6004 15.2596
RKN CTRP2 7.5893 8.9147 5.6034 0.299
GCT CTRP2 9.7127 19.7061 1.9755 10.6886
TE 617.T CTRP2 9.7247 34.5751 -5.2819 27.7554
HT-1080 CTRP2 10.4434 20.1253 2.2449 8.8529
SK-UT-1 CTRP2 10.8985 22.1223 1.6009 10.4347
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 4.5231 16.5192 -0.5092 27.6797
NCI-H28 CTRP2 6.6959 18.1819 0.5096 20.3386
MPP 89 CTRP2 6.7914 8.9282 5.1674 2.4692
IST-Mes1 CTRP2 7.0098 10.4518 4.5841 4.5058
NCI-H2052 CTRP2 7.1092 9.2354 5.2247 1.8519
ACC-MESO-1 CTRP2 7.1831 8.9888 5.3779 1.2225
JL-1 CTRP2 13.1907 24.0458 2.0703 6.5884
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 5.6082 12.9803 2.2066 16.7054
VCaP CTRP2 6.5805 11.2976 3.8501 8.2287
NCI-H660 CTRP2 6.8563 14.0765 2.6833 12.4598
LNCaP clone FGC CTRP2 7.0572 9.1393 5.2374 1.8639
PaCa-3 CTRP2 7.8651 8.86 5.7265 0.0536
DU145 CTRP2 8.259 10.0395 5.4568 0.3401
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 0.5302 8.7832 -0.8931 40.0027
A-253 CTRP2 7.2944 9.8756 5.0431 2.3202
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 CTRP2 -3.7666 -0.0776 -3.7763 64.9
SNU-620 CTRP2 -3.5392 -1.0525 -3.5396 63.7865
ECC10 CTRP2 -2.7546 7.9793 -4.1485 55.5483
SNU-16 CTRP2 -0.2837 5.5343 -0.7293 43.0531
NCC-StC-K140 CTRP2 2.2375 18.8157 -3.7373 38.8417
GSS CTRP2 2.3243 11.5669 -0.2084 32.6205
Fu97 CTRP2 3.575 5.8073 3.4103 17.0223
OCUM-1 CTRP2 5.1565 16.0757 0.2709 24.1614
SNU-216 CTRP2 5.5007 13.302 1.9531 17.8772
HuG1-N CTRP2 5.5169 12.7447 2.2451 16.7514
NCI-N87 CTRP2 5.9249 13.2416 2.3458 15.5266
23132/87 CTRP2 6.0887 8.8614 4.6727 5.6809
KATO III CTRP2 6.1173 7.3617 5.4455 2.3801
NUGC-3 CTRP2 6.1972 8.2976 5.0425 3.9256
SNU-5 CTRP2 6.2902 7.8887 5.3182 2.6096
SNU-1 CTRP2 6.3356 9.4659 4.5699 5.6581
Hs 746.T CTRP2 6.3441 11.4878 3.5683 9.8213
MKN45 CTRP2 6.8712 9.593 4.9029 3.4174
GSU CTRP2 6.8774 7.5355 5.8276 0.12
ECC12 CTRP2 7.0151 8.4129 5.5378 0.8339
MKN74 CTRP2 7.0284 9.359 5.1178 2.3548
IM95 CTRP2 7.364 28.3377 -4.0226 29.2708
SNU-668 CTRP2 7.4095 14.3889 2.9479 10.4845
AGS CTRP2 7.6652 11.6392 4.4549 4.1228
SH-10-TC CTRP2 7.7573 9.3078 5.5248 0.3977
LMSU CTRP2 8.053 14.3804 3.4082 7.699
MKN7 CTRP2 8.1504 10.048 5.4089 0.4815
SNU-601 CTRP2 8.3812 9.9533 5.5349 0.1785
KE-39 CTRP2 9.8994 20.048 1.9357 10.5791
SNU-719 CTRP2 10.4063 33.8186 -4.3964 25.4727
NUGC-4 CTRP2 11.9963 34.0972 -3.3846 21.6547
SNU-685 CTRP2 8.4228 10.0354 5.5214 0.1878
SNU-1077 CTRP2 8.6088 13.0993 4.3554 3.4132
SNG-M CTRP2 9.6295 18.5319 2.4758 9.0547
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 2.8074 7.2701 2.1149 24.0268
CGTH-W-1 CTRP2 4.483 10.8591 2.2378 19.1061
FTC-238 CTRP2 5.4106 12.0974 2.4747 16.0954
TT CTRP2 6.1117 9.4479 4.3984 6.7897
8305C CTRP2 6.5562 11.3603 3.8 8.4792
CAL-62 CTRP2 6.6829 8.4372 5.3291 1.9744
BHT-101 CTRP2 6.7942 10.5334 4.39 5.6327
B-CPAP CTRP2 7.0229 13.4079 3.143 10.3537
TT2609-C02 CTRP2 7.0347 15.5265 2.1012 14.3522
FTC-133 CTRP2 8.1227 9.3267 5.6584 0.0814
8505C CTRP2 8.6847 16.0383 3.0395 8.2372
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 2.5741 9.6237 0.9133 28.7818
CAL-27 CTRP2 3.2886 9.4268 1.732 24.0274
Detroit 562 CTRP2 3.7728 11.4958 1.2532 24.3834
CAL-33 CTRP2 3.9935 15.2496 -0.3621 28.5508
SCC-25 CTRP2 4.0609 13.8755 0.3738 26.393
BHY CTRP2 5.2134 12.1841 2.2572 17.3583
PE/CA-PJ49 CTRP2 5.5498 13.0629 2.1149 17.1728
PE/CA-PJ34 (clone C12) CTRP2 5.9008 13.3994 2.2465 15.9535
BICR 31 CTRP2 5.9042 6.943 5.4735 2.6847
BICR 18 CTRP2 6.2778 13.5268 2.4958 14.2561
SNU-899 CTRP2 6.2819 8.599 4.9593 4.1229
BICR 16 CTRP2 6.3773 8.0329 5.3121 2.4922
PE/CA-PJ15 CTRP2 6.4584 10.4636 4.1696 7.1142
PE/CA-PJ41 (clone D2) CTRP2 6.7282 8.2929 5.4261 1.5376
BICR 6 CTRP2 6.8113 12.7162 3.3241 9.9867
YD-8 CTRP2 6.8195 8.5108 5.3817 1.5969
SNU-1214 CTRP2 6.9337 15.5735 1.9992 14.9072
HSC-2 CTRP2 7.108 8.4138 5.5848 0.6116
SNU-1041 CTRP2 7.2907 9.9792 4.9932 2.5131
SCC-4 CTRP2 7.7572 9.7792 5.3376 0.886
BICR 22 CTRP2 7.8065 28.05 -3.5266 27.7425
SNU-1066 CTRP2 7.9459 9.3459 5.5868 0.2094
FaDu CTRP2 8.0386 13.4978 3.8199 6.1117
HSC-3 CTRP2 8.0497 15.0109 3.1023 8.8923
HSC-4 CTRP2 8.1205 15.8813 2.7303 10.2112
SNU-1076 CTRP2 8.2017 14.2058 3.5912 6.7815
SNU-46 CTRP2 8.5651 18.0578 1.9867 12.2685
SCC-9 CTRP2 9.6862 20.0735 1.7835 11.3768
BICR 56 CTRP2 11.3887 23.5668 1.2355 11.0004
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP2 -3.1837 0.7507 -3.2043 61.0846
RT-112 CTRP2 3.2768 11.5946 0.7239 27.3747
BFTC-905 CTRP2 4.8991 6.6738 4.5801 8.7972
VM-CUB-1 CTRP2 4.9485 12.999 1.6163 20.3005
UM-UC-1 CTRP2 5.0529 13.4471 1.4875 20.5176
U-BLC1 CTRP2 5.0797 17.3284 -0.4204 26.2196
647V CTRP2 5.1145 7.5144 4.4404 8.7815
CAL-29 CTRP2 5.4111 6.8321 5.0488 5.593
SCaBER CTRP2 5.8899 14.1088 1.8828 17.3279
BC-3C CTRP2 5.9645 9.2825 4.3583 7.2424
RT-4 CTRP2 6.0752 14.5796 1.8024 17.2471
253J CTRP2 6.8435 9.4465 4.9544 3.2494
HT-1376 CTRP2 6.96 8.9783 5.2521 1.9226
639V CTRP2 7.114 9.2156 5.2366 1.8022
SW1710 CTRP2 7.4242 9.8904 5.1132 1.9185
J82 CTRP2 7.4668 9.3873 5.3567 1.0443
JMSU-1 CTRP2 7.4759 16.4459 1.9831 14.0192
KU-19-19 CTRP2 7.8374 14.609 3.1487 9.0279
253J-BV CTRP2 8.128 9.4649 5.6128 0.13
HT-1197 CTRP2 8.2846 9.6033 5.6213 0.0945
T24 CTRP2 8.4853 13.639 4.0371 4.7176
TCCSUP CTRP2 8.5957 18.8436 1.6263 13.4759
KMBC-2 CTRP2 9.1861 22.5072 0.2617 16.8982
UM-UC-3 CTRP2 12.6657 24.6442 1.5112 8.76
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 5.0328 6.1518 4.9093 7.1757

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.Invest New Drugs.2013 Apr;31(2):370-80.
3 Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma?Cells. Am J Pathol. 2016 Jun;186(6):1674-87. doi: 10.1016/j.ajpath.2016.02.013. Epub 2016 Apr 20.