Details of the Drug

General Information of Drug (ID: DMN2XR7)

Drug Name

BCX-1470

Synonyms

BCX 1470; 217099-43-9; CHEMBL2220483; 2-(Aminoiminomethyl)benzo[b]thiophen-6-yl ester-2-Thiophenecarboxylic acid; SCHEMBL7614663; DTXSID30431348; ZINC95558579; BDBM50201566; AKOS030526719; 2-(Aminoiminomethyl)benzo[b]thiophen-6-yl ester 2-thiophenecarboxylic acid; CS-0313; RL02657; KB-74872; HY-50874; W-5553; 099A439; J-506195; 2-Thiophenecarboxylic acid 2-(aminoiminomethyl)benzo[b]thiophene-6-yl ester

Indication

Disease Entry	ICD 11	Status	REF
Bleeding disorder	GA20-GA21	Discontinued in Phase 1	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

302.4

Logarithm of the Partition Coefficient (xlogp)

3.7

Rotatable Bond Count (rotbonds)

4

Hydrogen Bond Donor Count (hbonddonor)

2

Hydrogen Bond Acceptor Count (hbondacc)

5

Chemical Identifiers

Formula: C14H10N2O2S2
IUPAC Name: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate
Canonical SMILES: C1=CSC(=C1)C(=O)OC2=CC3=C(C=C2)C=C(S3)C(=N)N
InChI: InChI=1S/C14H10N2O2S2/c15-13(16)12-6-8-3-4-9(7-11(8)20-12)18-14(17)10-2-1-5-19-10/h1-7H,(H3,15,16)
InChIKey: OTGQTQBPQCRNRG-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 9822205
TTD ID: D01IBO

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor IIa (F2)	TT6L509	THRB_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009938)
2	Recent Developments in Low Molecular Weight Complement Inhibitors. Mol Immunol. 2009 December; 47(2-3): 185-195.