Details of the Drug

General Information of Drug (ID: DMN6J18)

Drug Name

Vupanorsen

Synonyms

IONIS-ANGPTL3-LRx; AKCEA-ANGPTL3-LRx

Indication

Disease Entry	ICD 11	Status	REF
Hypertriglyceridemia	5C80.1	Phase 2	[1]
Non-alcoholic fatty liver disease	DB92	Phase 2	[1]
Type 2 diabetes	5A11	Phase 2	[1]
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Drug Type

Antisense oligonucleotide

Sequence

GGACATTGCCAGTAATCGCA

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ANGPTL3 messenger RNA (ANGPTL3 mRNA)	TT59GO7	ANGL3_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT03371355) Study of ISIS 703802 in Participants With Hypertriglyceridemia, Type 2 Diabetes Mellitus, and Nonalcoholic Fatty Liver Disease. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.