Details of the Drug

General Information of Drug (ID: DMNHU4M)

Drug Name

TRIM

Synonyms

Trim; 25371-96-4; 1-[2-(trifluoromethyl)phenyl]imidazole; 1-(2-Trifluoromethylphenyl)imidazole; 1-(2-(Trifluoromethyl)phenyl)-1H-imidazole; 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole; CHEMBL277525; WZBWBNCQUTXYEL-UHFFFAOYSA-N; NCGC00016047-03; 1H-Imidazole,1-[2-(trifluoromethyl)phenyl]-; DSSTox_RID_80756; DSSTox_CID_25217; DSSTox_GSID_45217; [2-(trifluoromethyl)phenyl]imidazole; 1-TRIM; CAS-25371-96-4; SR-01000076173; PubChem6489; Tocris-0919; ACMC-1CKKY; AC1L1BAW; AC1Q4JVD; Lopac-T-7313; Lopac0_001200; KBioSS_000064

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

212.17

Logarithm of the Partition Coefficient (xlogp)

2.6

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C10H7F3N2
IUPAC Name: 1-[2-(trifluoromethyl)phenyl]imidazole
Canonical SMILES: C1=CC=C(C(=C1)C(F)(F)F)N2C=CN=C2
InChI: InChI=1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H
InChIKey: WZBWBNCQUTXYEL-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 1359
ChEBI ID: CHEBI:109530
CAS Number: 25371-96-4
TTD ID: D0B3AR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V2 (TRPV2)	TTBECWA	TRPV2_HUMAN	Blocker (channel blocker)	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4331).
2	Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68.