Details of the Drug

General Information of Drug (ID: DMNQ3HV)

Drug Name
AZ20
Synonyms AZ-20; AZ 20; compound 6 [PMID: 46244454]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 412.5
Logarithm of the Partition Coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C21H24N4O3S
IUPAC Name
(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine
Canonical SMILES
C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4
InChI
InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1
InChIKey
SCGCBAAYLFTIJU-CQSZACIVSA-N
Cross-matching ID
PubChem CID
46244454
ChEBI ID
CHEBI:124915
TTD ID
D02TSN

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase ATR (FRP1) TT8ZYBQ ATR_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -0.6095 1.768 -0.6653 49.1849
ES1 GDSC1 -0.5444 2.3803 -0.6828 48.4874
HOS GDSC1 -0.5215 1.8404 -0.5801 48.1356
ES4 GDSC1 -0.5196 2.9768 -0.7815 48.3162
U2OS GDSC1 -0.3882 1.8847 -0.444 46.5276
ES7 GDSC1 -0.3703 2.871 -0.594 46.6352
EW-7 GDSC1 -0.3014 2.9108 -0.5281 45.87
NOS-1 [Human HNSCC] GDSC1 -0.2277 4.6648 -0.9867 45.979
ES8 GDSC1 -0.2122 2.8646 -0.4204 44.8198
TC-71 GDSC1 -0.1525 2.1531 -0.2264 43.7262
MHH-ES-1 GDSC1 0.1115 3.1717 -0.1419 41.2358
HuO9 GDSC1 0.1378 4.2756 -0.4533 42.0272
MG-63 GDSC1 0.1416 2.9821 -0.0623 40.6946
A-673 GDSC1 0.2981 3.1408 0.0696 38.9472
EW-16 GDSC1 0.3053 2.4061 0.2271 38.1413
EW-3 GDSC1 0.4681 7.1072 -1.2704 41.7613
CAL-72 GDSC1 0.4784 3.152 0.2634 36.7289
SJSA-1 GDSC1 0.6458 3.8351 0.2467 35.6591
NY GDSC1 0.765 4.1696 0.2614 34.795
EW-18 GDSC1 0.8648 4.3931 0.2871 34.0218
CHSA0108 GDSC1 0.884 4.5787 0.2371 34.148
SK-ES-1 GDSC1 1.16 4.992 0.3634 31.813
EW-1 GDSC1 1.2973 4.1973 0.8239 28.3529
EW-22 GDSC1 1.3188 5.8418 0.1601 31.9265
EW-11 GDSC1 1.3773 3.8671 1.0293 26.5819
H-EMC-SS GDSC1 1.7128 4.3162 1.2212 23.4362
ES5 GDSC1 1.8007 5.6461 0.7349 26.1423
HuO-3N1 GDSC1 1.9469 4.7405 1.2887 21.7415
G-292 clone A141B1 GDSC1 1.9595 9.2302 -0.8324 32.8349
ES6 GDSC1 2.0252 5.0106 1.2493 21.6195
CADO-ES1 GDSC1 2.1538 5.8576 0.9852 22.7832
CAL-78 GDSC1 2.2851 6.4014 0.8511 23.0347
CHSA8926 GDSC1 2.8437 5.4351 1.8444 13.4835
SaOS-2 GDSC1 2.8577 6.0141 1.5718 15.4867
EW-13 GDSC1 3.2434 7.1471 1.3435 15.6338
CHSA0011 GDSC1 3.5509 8.2705 1.0358 16.6413
EW-24 GDSC1 3.57 6.0545 2.1565 8.3221
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 156 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -0.4177 1.6696 -0.4541 46.8417
JURL-MK1 GDSC1 -3.7162 1.7881 -4.0012 73.5412
NU-DUL-1 GDSC1 -2.8637 -0.932 -2.8652 76.0164
ATN-1 GDSC1 -2.5255 -1.2746 -2.5255 72.9327
KE-37 GDSC1 -2.3169 -0.8553 -2.3172 70.252
HAL-01 GDSC1 -2.2278 1.4427 -2.3442 65.7778
SU-DHL-5 GDSC1 -2.1776 0.576 -2.2084 66.9403
BV-173 GDSC1 -1.9561 0.9436 -2.0036 64.3009
Karpas-231 GDSC1 -1.8879 -0.2381 -1.8893 64.906
CCRF-CEM GDSC1 -1.8782 0.1324 -1.8844 64.5163
697 GDSC1 -1.8537 -0.5876 -1.8538 64.6427
MOLM-13 GDSC1 -1.8363 0.7915 -1.8679 63.3486
GR-ST GDSC1 -1.7882 1.6725 -1.9064 61.7133
Karpas-299 GDSC1 -1.768 0.4379 -1.7806 63.0301
RPMI-8866 GDSC1 -1.7045 0.8214 -1.7332 61.9679
DG-75 GDSC1 -1.6494 0.6891 -1.6691 61.5141
SR GDSC1 -1.6031 0.8885 -1.6322 60.8344
NB4 GDSC1 -1.498 -0.1185 -1.4986 60.2037
LAMA-84 GDSC1 -1.4978 0.2877 -1.5021 60.0725
SKM-1 GDSC1 -1.4633 0.867 -1.4864 59.3355
BL-41 GDSC1 -1.461 -0.3064 -1.4611 59.7728
MOLT-16 GDSC1 -1.4514 -0.0026 -1.4523 59.6106
SUP-M2 GDSC1 -1.3835 -0.1778 -1.3838 58.8028
Ramos.2G6.4C10 GDSC1 -1.3825 1.6594 -1.4721 57.8433
CRO-AP2 GDSC1 -1.3475 1.9029 -1.4683 57.288
TK [Human B-cell lymphoma] GDSC1 -1.2736 2.5541 -1.5064 56.0627
RCH-ACV GDSC1 -1.1771 0.6537 -1.1846 56.1302
EoL-1 GDSC1 -1.1432 0.7137 -1.1517 55.707
MEG-01 GDSC1 -1.1205 0.6244 -1.1264 55.455
HEL GDSC1 -1.1196 0.7325 -1.1282 55.4193
OCI-Ly7 GDSC1 -1.0952 0.1774 -1.0958 55.2032
L-540 GDSC1 -1.0709 0.8222 -1.0814 54.8139
BALL-1 GDSC1 -1.0384 0.4518 -1.0406 54.4784
JSC-1 GDSC1 -1.0243 5.0934 -2.0004 52.6635
L-363 GDSC1 -0.9937 1.5909 -1.0523 53.6884
RS4;11 GDSC1 -0.9567 1.4874 -1.0032 53.2947
JeKo-1 GDSC1 -0.9537 0.5342 -0.9562 53.4266
NOMO-1 GDSC1 -0.9431 1.2419 -0.97 53.1945
CTB-1 GDSC1 -0.9237 2.0333 -1.0338 52.7693
MOLM-16 GDSC1 -0.8509 1.7301 -0.9164 52.021
Loucy GDSC1 -0.8354 0.9806 -0.8461 51.9356
MY-M12 GDSC1 -0.7988 6.5884 -2.3518 50.8046
KCL-22 GDSC1 -0.7679 0.4298 -0.7685 51.1214
RPMI-8226 GDSC1 -0.7513 0.7295 -0.7545 50.9109
MHH-PREB-1 GDSC1 -0.735 1.0222 -0.7449 50.7016
MV4-11 GDSC1 -0.7055 2.2899 -0.8407 50.3086
NALM-6 GDSC1 -0.6301 1.293 -0.6491 49.4129
OCI-Ly19 GDSC1 -0.6287 4.7913 -1.4643 49.5869
SUP-B15 GDSC1 -0.621 2.4569 -0.7796 49.3642
WSU-NHL GDSC1 -0.584 2.2059 -0.6961 48.9213
JVM-3 GDSC1 -0.5794 3.1971 -0.9023 48.9864
Namalwa GDSC1 -0.5727 1.7764 -0.6273 48.744
GA-10 GDSC1 -0.5492 2.5578 -0.7214 48.5694
KMS-12-BM GDSC1 -0.5275 1.4004 -0.5491 48.1576
EJM GDSC1 -0.5215 1.7029 -0.5659 48.1165
A4/Fukuda GDSC1 -0.5101 2.8111 -0.7325 48.1791
A3/Kawakami GDSC1 -0.4166 2.3876 -0.5462 47.0062
BE-13 GDSC1 -0.4028 2.3343 -0.5222 46.8282
MM1.S GDSC1 -0.4006 2.5237 -0.5538 46.8615
CML-T1 GDSC1 -0.3533 1.8388 -0.4022 46.0871
U-698-M GDSC1 -0.3418 1.1539 -0.348 45.821
TUR GDSC1 -0.316 1.8377 -0.3628 45.628
SU-DHL-8 GDSC1 -0.2819 1.7954 -0.3228 45.1938
Ku812 GDSC1 -0.2407 4.7558 -1.034 46.1448
RPMI-8402 GDSC1 -0.2339 1.1182 -0.2377 44.4659
Karpas-1106P GDSC1 -0.2323 3.1589 -0.5136 45.2128
P30/OHK GDSC1 -0.2246 2.3031 -0.3255 44.6796
DB GDSC1 -0.2183 4.7539 -1.0093 45.9361
MOLT-4 GDSC1 -0.18 1.6369 -0.2036 43.8779
EM-2 GDSC1 -0.1608 2.109 -0.2295 43.8086
OCI-M1 GDSC1 -0.1314 1.6827 -0.1562 43.2814
NCI-H929 GDSC1 -0.1229 2.2316 -0.2057 43.3978
OCI-AML-2 GDSC1 -0.1067 1.4586 -0.1182 42.9156
Granta-519 GDSC1 -0.0569 2.9835 -0.2788 43.0753
K-562 GDSC1 -0.0319 1.2655 -0.0359 41.9453
WIL2 NS GDSC1 0.0237 2.1502 -0.0384 41.5287
Jiyoye GDSC1 0.0268 1.5893 0.0132 41.2626
ST486 GDSC1 0.0536 3.174 -0.2057 41.9252
VAL GDSC1 0.0796 3.9872 -0.4182 42.3762
SU-DHL-10 GDSC1 0.1382 1.409 0.1336 39.8237
ML-2 GDSC1 0.1741 2.5392 0.0643 39.9035
Farage GDSC1 0.1782 3.8095 -0.2535 41.1047
NKM-1 GDSC1 0.2193 4.907 -0.5985 41.8217
PL-21 GDSC1 0.2277 4.1397 -0.3089 40.9119
Kasumi-1 GDSC1 0.287 3.4111 -0.015 39.3912
Karpas-45 GDSC1 0.3056 2.6482 0.1866 38.3448
DND-41 GDSC1 0.3298 3.5251 -0.0012 39.0159
QIMR-WIL GDSC1 0.3373 2.1657 0.2925 37.5664
SU-DHL-16 GDSC1 0.3609 1.8906 0.3413 37.1299
CMK GDSC1 0.3794 3.6743 0.008 38.6139
Mono-Mac-6 GDSC1 0.397 3.0307 0.2045 37.5975
P12-Ichikawa GDSC1 0.4524 2.3658 0.3902 36.2346
SU-DHL-6 GDSC1 0.4569 2.0955 0.4256 36.001
SUP-B8 GDSC1 0.4682 4.8643 -0.3167 39.2149
ALL-SIL GDSC1 0.5148 3.1161 0.312 36.2277
CTV-1 GDSC1 0.5665 2.3898 0.5086 34.7927
OCI-AML-3 GDSC1 0.6242 4.5738 -0.0386 37.0974
RL GDSC1 0.6269 2.0947 0.6037 33.8309
L-1236 GDSC1 0.6733 4.0639 0.1995 35.7033
PF-382 GDSC1 0.7574 3.2478 0.5431 33.3426
SUP-HD1 GDSC1 0.7693 3.4529 0.4993 33.5128
JVM-2 GDSC1 0.7928 3.4034 0.5392 33.1355
DEL GDSC1 0.8272 2.7222 0.7365 31.7479
RPMI-6666 GDSC1 0.8719 5.3291 -0.0787 35.6635
HT GDSC1 0.8791 3.9365 0.466 32.9904
WSU-DLCL2 GDSC1 0.8929 3.4628 0.6313 31.9646
HH [Human lymphoma] GDSC1 0.9009 6.0295 -0.3498 36.5569
MOLP-8 GDSC1 0.9323 4.7861 0.2071 33.991
L-428 GDSC1 0.9476 3.2574 0.7481 30.9227
Reh GDSC1 0.9686 3.8925 0.5779 31.7998
MLMA GDSC1 1.0805 4.5583 0.4543 31.803
MOLT-13 GDSC1 1.0945 3.3053 0.8956 29.1063
ARH-77 GDSC1 1.1184 4.5828 0.485 31.4046
KG-1 GDSC1 1.1419 3.9592 0.7427 29.7688
JJN-3 GDSC1 1.2628 4.9428 0.4915 30.5155
MHH-CALL-2 GDSC1 1.3097 5.122 0.4651 30.3907
KMOE-2 GDSC1 1.3164 3.5618 1.0633 26.7122
Karpas-620 GDSC1 1.3201 3.7868 0.9947 27.1368
P32/ISH GDSC1 1.454 3.7023 1.1682 25.2278
H9 GDSC1 1.4676 3.1451 1.3436 23.9824
AMO1 GDSC1 1.5211 3.9528 1.1544 24.9403
Raji GDSC1 1.5957 5.7337 0.489 28.6695
Jurkat GDSC1 1.6082 2.7899 1.5655 21.694
HL-60 GDSC1 1.621 4.5882 1.014 25.3197
OPM-2 GDSC1 1.658 3.2167 1.5337 21.6088
KMS-11 GDSC1 1.6624 4.6611 1.0271 25.0099
P31/FUJ GDSC1 1.6874 6.2439 0.3462 28.9697
BC-1 GDSC1 1.6895 4.0108 1.3142 22.9263
EB2 GDSC1 1.7198 3.3909 1.5542 21.1159
EHEB GDSC1 1.7284 6.0273 0.4874 27.9772
RC-K8 GDSC1 1.7303 4.3977 1.2068 23.44
ALL-PO GDSC1 1.7499 6.3102 0.3769 28.4794
VL51 GDSC1 1.7572 5.5541 0.7332 26.3786
Karpas-422 GDSC1 1.8071 5.7841 0.6779 26.4554
KM-H2 GDSC1 1.922 5.2994 1.0148 23.7335
YT GDSC1 1.9846 4.2861 1.5202 19.9153
Sc-1 GDSC1 2.0771 3.4609 1.923 16.5821
CESS GDSC1 2.0849 5.3247 1.1664 21.8967
OCI-AML-5 GDSC1 2.1526 4.4091 1.6442 18.1669
KY821 GDSC1 2.1875 5.116 1.3648 20.0074
THP-1 GDSC1 2.2833 5.5502 1.2567 20.3142
IM-9 GDSC1 2.3493 4.672 1.7298 16.5723
HDLM-2 GDSC1 2.3897 6.424 0.9389 21.9829
LP-1 GDSC1 2.4668 5.5651 1.4269 18.25
Daudi GDSC1 2.645 6.0458 1.3616 17.9303
MC116 GDSC1 2.8989 4.4225 2.3889 9.0489
CA46 GDSC1 3.1379 7.4018 1.1267 17.5627
HC-1 GDSC1 3.1536 8.1768 0.7528 19.9648
ME1 GDSC1 3.4865 6.504 1.8659 10.8564
SU-DHL-4 GDSC1 3.5446 4.939 2.6906 4.2281
MN-60 GDSC1 3.5605 8.0066 1.1753 15.6578
SUP-T1 GDSC1 3.6272 8.7032 0.8813 17.389
LC4-1 GDSC1 3.6387 6.2588 2.1084 8.469
SK-MM-2 GDSC1 3.6675 6.4997 2.0111 9.1274
ROS-50 GDSC1 4.0421 7.7792 1.6613 10.5826
GDM-1 GDSC1 4.8389 7.0796 2.5059 2.5954
⏷ Show the Full List of 156 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC1 -1.1804 1.4307 -1.233 55.8484
KYSE-50 GDSC1 -0.7966 2.0306 -0.8974 51.3553
KYSE-220 GDSC1 -0.7878 2.3411 -0.9385 51.2161
TE-12 GDSC1 0.2751 3.6089 -0.0858 39.7637
KYAE-1 GDSC1 0.4961 4.0642 0.0076 37.783
HCE-4 GDSC1 1.0465 3.3281 0.837 29.7662
SK-GT-4 GDSC1 1.1081 4.4473 0.5267 31.2347
FLO-1 GDSC1 1.1294 8.8968 -1.4522 38.6099
OACP4 C GDSC1 1.1342 6.7574 -0.4411 35.5422
ESO-26 GDSC1 2.1641 4.3959 1.6618 17.9811
OACM5.1 C GDSC1 3.6033 6.5865 1.9178 10.0582
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -0.2641 1.7413 -0.2993 44.9578
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GOTO GDSC1 -1.6138 1.7573 -1.7321 60.0097
CHP-212 GDSC1 -1.515 1.1131 -1.5563 59.6957
SK-N-DZ GDSC1 -1.0651 1.9436 -1.172 54.3378
SK-N-AS GDSC1 -0.8858 2.1136 -1.0055 52.3322
SJNB-14 GDSC1 -0.8643 1.7906 -0.9377 52.1636
SK-N-MC-IXC GDSC1 -0.693 0.7194 -0.6955 50.1856
SK-N-SH GDSC1 -0.4804 4.2316 -1.1075 48.1928
SiMa GDSC1 -0.4418 2.067 -0.5234 47.2205
GI-ME-N GDSC1 -0.3923 2.1144 -0.477 46.6375
CHP-126 GDSC1 -0.2517 2.8261 -0.4547 45.2575
NB69 GDSC1 -0.1739 2.0103 -0.2312 43.9279
SJNB-10 GDSC1 -0.0827 2.8222 -0.2701 43.2671
Kelly GDSC1 0.0973 4.5654 -0.6008 42.7242
SJNB-7 GDSC1 0.1032 1.9092 0.0711 40.4061
TGW GDSC1 0.1509 2.1087 0.1016 39.9012
SJNB-5 GDSC1 0.3012 5.4675 -0.7345 41.6004
SJNB-13 GDSC1 0.434 2.1196 0.3992 36.3072
NH-12 GDSC1 0.6268 2.7331 0.5179 34.3416
SK-N-BE(2)-M17 GDSC1 0.8208 3.9214 0.4079 33.6783
SJNB-17 GDSC1 0.9287 3.3566 0.7006 31.328
LA-N-6 GDSC1 1.2285 4.0305 0.811 28.8359
IMR-5 GDSC1 1.6656 2.8559 1.617 21.0146
SJNB-12 GDSC1 1.6967 4.4372 1.1553 23.9696
NB1 GDSC1 1.9696 7.5261 0.0085 29.2767
SK-N-FI GDSC1 2.0589 5.0606 1.2609 21.3711
NB(TU)1 GDSC1 3.5164 6.5503 1.8668 10.7456
SJNB-6 GDSC1 3.5314 7.593 1.3583 14.4735
KP-N-YN GDSC1 5.0063 7.837 2.2655 3.847
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -0.3838 2.1865 -0.4783 46.5569
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 GDSC1 -2.2344 -0.5711 -2.2354 69.0922
MCF-7 GDSC1 -1.178 2.5224 -1.396 55.1735
HCC1806 GDSC1 -0.9171 2.8087 -1.1749 52.4707
MDA-MB-157 GDSC1 -0.8665 2.743 -1.1049 51.9749
JIMT-1 GDSC1 -0.3642 2.0214 -0.4346 46.2709
MDA-MB-231 GDSC1 -0.1541 2.6279 -0.3071 43.9974
BT-549 GDSC1 0.2514 2.9747 0.059 39.3436
UACC-893 GDSC1 0.3592 4.3164 -0.2287 39.6743
HCC1143 GDSC1 0.4414 4.1468 -0.0802 38.5284
MDA-MB-361 GDSC1 0.4486 2.9993 0.2681 36.9143
DU4475 GDSC1 0.891 3.5034 0.6172 32.0594
HCC1954 GDSC1 0.9015 4.0749 0.4423 32.9778
HCC1569 GDSC1 0.9178 5.3082 -0.0219 35.1353
HCC38 GDSC1 1.0236 4.8809 0.2656 33.1377
CAL-85-1 GDSC1 1.0325 4.4096 0.4604 32.0623
CAL-120 GDSC1 1.0424 4.4317 0.4626 31.9894
Hs 578T GDSC1 1.0884 4.3335 0.549 31.2281
T-47D GDSC1 1.1562 5.48 0.1525 32.8988
MDA-MB-453 GDSC1 1.2064 3.4783 0.9687 27.9712
HCC2157 GDSC1 1.2685 4.4497 0.6968 29.2962
MDA-MB-175-VII GDSC1 1.4668 3.3891 1.2786 24.419
OCUB-M GDSC1 1.4984 3.6483 1.234 24.5354
HCC1500 GDSC1 1.5324 4.6454 0.8973 26.5595
HCC70 GDSC1 1.7651 4.6733 1.1291 23.7821
HCC1937 GDSC1 1.8044 5.178 0.9501 24.7628
AU565 GDSC1 1.8833 5.0463 1.0891 23.435
BT-20 GDSC1 1.9344 6.034 0.6877 25.7496
CAMA-1 GDSC1 1.9856 5.2945 1.081 22.9705
HCC1187 GDSC1 2.3306 5.2665 1.4366 18.8092
Evsa-T GDSC1 2.3638 4.8159 1.6787 16.8802
HCC1419 GDSC1 2.3969 8.0504 0.1486 26.5982
MFM-223 GDSC1 2.4443 5.4992 1.4369 18.2796
MRK-nu-1 GDSC1 2.6459 7.8903 0.4525 23.8479
MDA-MB-436 GDSC1 2.6578 5.5594 1.6109 16.0454
MDA-MB-468 GDSC1 2.6649 5.5032 1.6449 15.7603
EFM-192A GDSC1 2.7015 5.8903 1.49 16.7518
EFM-19 GDSC1 2.7209 6.5876 1.1647 18.9969
HDQ-P1 GDSC1 2.7423 5.2971 1.8177 14.1191
HCC1428 GDSC1 2.7581 7.2786 0.8561 20.9073
HCC1395 GDSC1 3.0547 8.0946 0.7094 20.6244
COLO 824 GDSC1 3.4135 7.0276 1.5448 13.5378
BT-474 GDSC1 3.4916 6.5505 1.8468 10.9845
ZR-75-30 GDSC1 3.8724 6.9057 1.9656 8.8261
HCC202 GDSC1 4.0829 8.6725 1.2513 13.382
HCC2218 GDSC1 4.4133 10.1211 0.7834 15.4317
BT-483 GDSC1 4.4179 10.5855 0.5582 16.788
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC1 -1.9909 0.3832 -2.0066 65.4297
SF539 GDSC1 -1.7561 0.2782 -1.7637 63.04
8-MG-BA GDSC1 -1.6829 1.607 -1.7852 60.8358
ONS-76 GDSC1 -0.999 0.8542 -1.009 53.9402
Daoy GDSC1 -0.8109 1.1304 -0.8272 51.6249
T98G GDSC1 -0.7398 1.6493 -0.7905 50.7341
D-566MG GDSC1 -0.5971 1.4988 -0.628 49.0184
H4 GDSC1 -0.5717 3.7651 -1.0561 48.9797
Becker GDSC1 -0.4821 2.1669 -0.5807 47.7221
GI-1 GDSC1 -0.3237 1.9366 -0.3815 45.7515
KALS-1 GDSC1 -0.1931 3.1062 -0.4575 44.7392
YH-13 GDSC1 -0.1298 2.7873 -0.3137 43.8047
LN-229 GDSC1 -0.1215 2.844 -0.317 43.7421
Hs 683 GDSC1 0.1262 3.2679 -0.1511 41.1533
SF295 GDSC1 0.1605 3.2411 -0.1065 40.7185
42-MG-BA GDSC1 0.173 3.6068 -0.1964 40.9487
MOG-G-UVW GDSC1 0.2125 2.678 0.0801 39.5417
AM-38 GDSC1 0.2308 5.6242 -0.8728 42.4102
KS-1 [Human Krukenberg tumour] GDSC1 0.2622 4.3893 -0.3594 40.8178
YKG-1 GDSC1 0.3046 2.6318 0.1885 38.3432
SW1088 GDSC1 0.456 3.8245 0.0439 37.9106
LNZTA3WT4 GDSC1 0.4561 3.0968 0.2529 36.9384
D-336MG GDSC1 0.54 4.5932 -0.136 38.0605
GaMG GDSC1 0.601 2.9654 0.4417 34.9448
SW1783 GDSC1 0.6033 4.0264 0.1366 36.4719
D-423MG GDSC1 0.8307 4.5511 0.1907 34.7134
D-263MG GDSC1 0.9244 3.5965 0.6256 31.8
LN-18 GDSC1 1.0851 3.1578 0.9236 28.9872
SK-MG-1 GDSC1 1.091 3.8752 0.7165 30.2331
SF126 GDSC1 1.0953 3.6112 0.8072 29.6543
GB-1 GDSC1 1.3284 3.4494 1.1103 26.3351
NMC-G1 GDSC1 1.3304 3.4702 1.1062 26.3502
SF268 GDSC1 1.3733 4.682 0.715 28.583
U-118MG GDSC1 1.4832 3.8014 1.1666 25.0724
M059J GDSC1 1.4954 4.8118 0.7895 27.4415
A-172 GDSC1 1.4985 4.5879 0.8852 26.8249
PFSK-1 GDSC1 1.5493 3.4511 1.3507 23.4622
U-251MG GDSC1 1.5918 3.4452 1.3987 22.8962
KNS-81-FD GDSC1 1.6964 5.0119 0.9126 25.5726
U-87MG ATCC GDSC1 1.8738 7.339 0.008 29.745
CAS-1 GDSC1 1.9444 5.5651 0.9157 24.2691
DBTRG-05MG GDSC1 1.9861 5.0192 1.2059 22.1167
SNB-75 GDSC1 2.0026 8.8983 -0.6299 31.8877
DK-MG GDSC1 2.1803 5.8263 1.0258 22.3866
MOG-G-CCM GDSC1 2.2384 5.7756 1.1063 21.5667
LN-405 GDSC1 2.2631 6.4013 0.8303 23.2704
Onda 11 GDSC1 2.4233 5.4704 1.4303 18.4236
D-392MG GDSC1 2.438 5.2434 1.5525 17.4642
D-542MG GDSC1 2.4838 6.4307 1.0237 20.9951
Onda 10 GDSC1 2.5262 4.7352 1.8775 14.6339
KINGS-1 GDSC1 2.8007 5.3518 1.8455 13.6571
D-502MG GDSC1 2.8869 7.9022 0.6599 21.606
KNS-42 GDSC1 3.0942 8.1505 0.7154 20.4312
D-247MG GDSC1 3.2689 7.991 0.943 18.297
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -0.5255 4.2622 -1.1667 48.6182
TGBC24TKB GDSC1 0.4752 3.0033 0.296 36.5855
TGBC1TKB GDSC1 0.6692 6.2465 -0.6827 39.0777
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-296 GDSC1 -2.8884 3.0805 -3.3912 66.755
MFE-319 GDSC1 -0.745 1.9991 -0.8377 50.7714
ESS-1 GDSC1 0.6771 2.3963 0.6255 33.378
AN3-CA GDSC1 1.0545 4.1608 0.5766 31.2775
EN GDSC1 2.0863 5.1617 1.2426 21.3627
KLE GDSC1 2.465 7.2266 0.6164 23.6733
MFE-280 GDSC1 3.9195 6.3479 2.2734 6.334
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
769-P GDSC1 -3.1078 -0.9732 -3.1104 78.188
LB2241-RCC GDSC1 -1.3721 0.8078 -1.3894 58.3491
ACHN GDSC1 -1.2822 2.6001 -1.5256 56.109
LB1047-RCC GDSC1 -1.2764 1.7373 -1.3692 56.6903
KTCTL-140 GDSC1 -0.7622 2.6822 -0.9782 50.8995
UO-31 GDSC1 -0.5402 2.1311 -0.6377 48.4008
KTCTL-1M GDSC1 -0.3749 3.8862 -0.8797 47.0681
A-498 GDSC1 -0.3556 4.8244 -1.1827 47.2197
KTCTL-195 GDSC1 -0.1542 3.9172 -0.6494 44.82
Caki-1 GDSC1 -0.0053 4.5816 -0.7171 43.7727
BFTC-909 GDSC1 0.0595 1.9197 0.0243 40.9638
BB65-RCC GDSC1 0.0649 3.4978 -0.2821 42.0856
KMRC-1 GDSC1 0.2743 5.0178 -0.583 41.3886
SW13 GDSC1 0.5034 4.5197 -0.1477 38.3578
HA7-RCC GDSC1 0.5312 2.8651 0.3878 35.7125
LB996-RCC GDSC1 0.541 5.275 -0.4034 39.017
SW156 GDSC1 0.7737 3.7372 0.4175 33.9323
KTCTL-13 GDSC1 0.7758 4.5882 0.118 35.4092
KMRC-20 GDSC1 0.7789 3.9658 0.3475 34.2672
TK-10 GDSC1 0.8211 3.6719 0.4897 33.2313
KTCTL-26A GDSC1 0.8575 4.7915 0.1257 34.8492
OS-RC-2 GDSC1 0.8911 5.9273 -0.3151 36.4865
NCC010 GDSC1 1.1272 3.2956 0.9338 28.6676
RXF 393L GDSC1 1.1276 3.8405 0.7679 29.7008
VMRC-RCZ GDSC1 1.2686 4.7954 0.5584 30.105
KTCTL-21 GDSC1 1.6636 5.7206 0.5633 27.8837
SN12C GDSC1 1.7771 5.8327 0.6257 26.923
CAL-54 GDSC1 1.8325 5.2078 0.9654 24.5166
NCC021 GDSC1 2.0714 5.9168 0.8769 23.889
RCC10RGB GDSC1 3.5321 10.6701 -0.1785 23.7343
786-O GDSC1 4.9352 9.3352 1.5301 9.0407
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320HSR GDSC1 -0.8647 1.344 -0.8955 52.2469
RKO GDSC1 -0.4456 1.437 -0.4664 47.1486
CCK-81 GDSC1 -0.1952 1.4699 -0.2097 44.0292
MDST8 GDSC1 -0.186 1.739 -0.2174 43.9828
HCT 116 GDSC1 0.3006 3.7787 -0.1105 39.6685
LS411N GDSC1 0.4509 5.643 -0.65 40.3709
LoVo GDSC1 0.4876 3.7914 0.0889 37.4898
LS513 GDSC1 0.9516 4.1821 0.458 32.5767
SW620 GDSC1 1.0146 4.224 0.5105 31.8957
SNU-C2B GDSC1 1.1321 4.6454 0.4748 31.379
NCI-H716 GDSC1 1.1673 6.6358 -0.3523 35.0206
HCT 15 GDSC1 1.1823 3.334 0.9836 28.0195
RCM-1 [Human ESC] GDSC1 1.5648 5.8838 0.3897 29.3848
SW626 GDSC1 1.8085 5.0602 1.0065 24.3716
SNU-407 GDSC1 1.8105 5.1452 0.9709 24.5951
C2BBe1 GDSC1 1.8144 4.0454 1.4349 21.4148
NCI-H508 GDSC1 1.859 5.7186 0.7599 25.6887
LS1034 GDSC1 1.8741 5.8643 0.7074 25.9344
KM12 GDSC1 1.9152 4.8848 1.1931 22.5653
DiFi GDSC1 1.9922 6.1028 0.7119 25.3145
SW48 GDSC1 2.0031 4.1979 1.5756 19.4253
SK-CO-1 GDSC1 2.0128 6.2012 0.6854 25.3744
GP5d GDSC1 2.0825 4.3452 1.5983 18.8533
HCC2998 GDSC1 2.1083 6.5233 0.624 25.2798
HT-29 GDSC1 2.1112 5.239 1.2321 21.3127
CL-11 GDSC1 2.2496 10.1464 -1.0206 32.2373
LS180 GDSC1 2.291 6.3894 0.8625 22.9346
CaR-1 GDSC1 2.4028 5.8373 1.235 19.9111
LS123 GDSC1 2.4493 5.1466 1.6092 16.9932
SNU-C5 GDSC1 2.5561 5.7776 1.4093 17.9763
SNU-81 GDSC1 2.5848 7.5661 0.558 23.4949
NCI-H747 GDSC1 2.7048 5.8897 1.4934 16.7125
SNU-C1 GDSC1 2.7438 8.2835 0.3443 24.0469
SW1463 GDSC1 2.9831 6.2738 1.5549 15.1015
HT115 GDSC1 3.0818 6.2938 1.6315 14.1376
COLO205 GDSC1 3.1192 8.341 0.6415 20.7895
CW-2 GDSC1 3.2186 8.9055 0.4436 21.5819
SW1417 GDSC1 3.3385 8.2728 0.8603 18.5741
T84 GDSC1 3.8572 8.1432 1.3415 13.4798
HT-55 GDSC1 3.9269 7.4115 1.7568 10.2309
SW948 GDSC1 3.9774 6.9911 2.0008 8.2412
SNU-61 GDSC1 4.1298 7.9076 1.6626 10.3078
SW1116 GDSC1 4.1826 8.0711 1.6208 10.4549
SW837 GDSC1 4.21 8.9187 1.2247 13.1685
COLO 678 GDSC1 4.7585 8.7358 1.6983 8.3187
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 0.3851 4.3475 -0.2119 39.4285
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-1 GDSC1 -0.2387 3.4871 -0.6102 45.4647
HLE GDSC1 -0.0315 2.0602 -0.0861 42.1742
JHH-1 GDSC1 0.242 3.2377 -0.0167 39.7372
SNU-398 GDSC1 0.2784 2.4683 0.1885 38.5332
JHH-2 GDSC1 0.6052 4.7652 -0.1322 37.604
Hep-G2/C3A GDSC1 0.6413 3.9557 0.2018 35.9076
Huh-7 GDSC1 0.8628 4.875 0.098 34.9437
JHH-6 GDSC1 0.8984 3.7389 0.5525 32.385
Hep 3B2.1-7 GDSC1 1.3391 3.7299 1.0342 26.77
JHH-7 GDSC1 1.4086 4.4487 0.8461 27.576
SNU-387 GDSC1 1.469 4.1873 1.0116 26.176
SNU-423 GDSC1 2.1021 4.9293 1.3638 20.4327
JHH-4 GDSC1 2.1963 3.9296 1.887 16.1905
SK-HEP-1 GDSC1 2.2221 4.3947 1.7224 17.2503
SNU-449 GDSC1 2.3562 4.5796 1.7783 16.1798
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 176 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 GDSC1 -1.5946 1.4655 -1.6739 60.1545
NCI-H1568 GDSC1 -1.2534 1.0569 -1.2802 56.8638
NCI-H460 GDSC1 -1.196 1.1386 -1.2259 56.1702
NCI-H647 GDSC1 -1.0277 1.5013 -1.0791 54.1037
HCC78 GDSC1 -1.0255 1.9605 -1.1321 53.9037
NCI-H2122 GDSC1 -0.8929 2.2415 -1.0343 52.3777
EPLC-272H GDSC1 -0.8483 2.2071 -0.9804 51.9
LC-1/sq GDSC1 -0.7536 4.1384 -1.3729 50.6758
NCI-H2023 GDSC1 -0.7215 3.139 -1.0422 50.4421
Lu-99A GDSC1 -0.6932 2.922 -0.9575 50.1584
A-549 GDSC1 -0.6359 3.5635 -1.0657 49.5887
NCI-H292 GDSC1 -0.5696 4.9395 -1.4551 49.1012
EBC-1 GDSC1 -0.4308 3.1611 -0.7307 47.4027
NCI-H2373 GDSC1 -0.3576 2.8884 -0.5841 46.4981
HARA [Human squamous cell lung carcinoma] GDSC1 -0.1197 3.3213 -0.4338 44.0443
NCI-H82 GDSC1 -0.0768 2.3841 -0.1796 42.913
HOP-62 GDSC1 -0.05 3.1676 -0.317 43.1339
NCI-H23 GDSC1 0.051 2.6521 -0.0897 41.5215
NCI-H1755 GDSC1 0.0828 2.9415 -0.1169 41.3719
NCI-H1155 GDSC1 0.139 1.6336 0.1264 39.8586
A-427 GDSC1 0.1533 3.1172 -0.0824 40.6823
LCLC-97TM1 GDSC1 0.1681 3.2543 -0.1017 40.6414
NCI-H1793 GDSC1 0.1682 5.7234 -0.9795 43.0652
NCI-H1876 GDSC1 0.2056 1.9444 0.1754 39.1241
HCC44 GDSC1 0.2745 5.8 -0.9001 42.1772
CPC-N GDSC1 0.2912 3.2527 0.033 39.1584
NCI-H661 GDSC1 0.2964 3.1432 0.0672 38.9702
NCI-H290 GDSC1 0.2967 2.6747 0.172 38.4816
RERF-LC-Sq1 GDSC1 0.3431 4.6196 -0.3569 40.2247
SK-LU-1 GDSC1 0.362 5.5591 -0.7083 41.1212
NCI-H209 GDSC1 0.4525 4.181 -0.0801 38.4494
PC-14 GDSC1 0.4816 3.0079 0.302 36.5096
DMS 273 GDSC1 0.497 3.8827 0.0694 37.5101
NCI-H2009 GDSC1 0.5129 3.4734 0.2137 36.7327
NCI-H2810 GDSC1 0.5224 3.7733 0.1325 37.0491
EMC-BAC-2 GDSC1 0.5382 4.4037 -0.0675 37.8006
LXF 289 GDSC1 0.5403 3.9882 0.0813 37.1554
COR-L23 GDSC1 0.5525 2.5193 0.4748 35.0818
SBC-5 GDSC1 0.5577 2.9752 0.3924 35.5074
NCI-H2461 GDSC1 0.5719 4.5616 -0.09 37.6613
NCI-H1944 GDSC1 0.5728 3.6823 0.2161 36.3059
RERF-LC-MS GDSC1 0.5864 3.7711 0.2028 36.2762
NCI-H1299 GDSC1 0.6191 3.2547 0.3903 35.1032
IST-SL2 GDSC1 0.6201 3.3585 0.3633 35.2398
NCI-H1648 GDSC1 0.6502 5.0149 -0.183 37.5031
NCI-H1437 GDSC1 0.6707 3.3554 0.4194 34.601
NCI-H1341 GDSC1 0.7181 2.7161 0.6198 33.1487
Calu-6 GDSC1 0.7469 6.011 -0.4999 38.0231
Lu-135 GDSC1 0.7721 3.776 0.4032 34.0196
LCLC-103H GDSC1 0.8067 3.3237 0.5765 32.8328
NCI-H2347 GDSC1 0.8217 2.8244 0.7114 31.9359
CAL-12T GDSC1 0.8359 3.9095 0.4284 33.4711
SK-MES-1 GDSC1 0.8363 3.8074 0.4627 33.2824
NCI-H1734 GDSC1 0.8896 6.6842 -0.6534 37.671
NCI-H64 GDSC1 0.8936 2.875 0.779 31.0697
BEN GDSC1 0.9221 5.0245 0.1001 34.5618
NCI-H1792 GDSC1 0.9251 3.0792 0.7682 30.9399
NCI-H2030 GDSC1 0.965 4.7602 0.252 33.5671
NCI-H838 GDSC1 0.9815 4.6848 0.2994 33.2262
NCI-H2803 GDSC1 1.0266 5.0143 0.2142 33.3746
LB647-SCLC GDSC1 1.0614 3.3883 0.8365 29.6785
EMC-BAC-1 GDSC1 1.0918 4.0567 0.6542 30.5997
NCI-H1693 GDSC1 1.1163 3.3322 0.9121 28.8709
VMRC-LCD GDSC1 1.1449 3.0397 1.0167 28.0311
NCI-H720 GDSC1 1.1473 3.5071 0.8957 28.788
NCI-H524 GDSC1 1.1598 3.982 0.7541 29.5922
NCI-H847 GDSC1 1.1965 3.1294 1.0519 27.4949
NCI-H3122 GDSC1 1.197 3.8667 0.8342 28.8775
NCI-H2804 GDSC1 1.2391 5.5977 0.1867 32.2504
NCI-H2818 GDSC1 1.279 4.5392 0.6727 29.3785
NCI-H841 GDSC1 1.2947 4.2299 0.8089 28.461
NCI-H1651 GDSC1 1.3651 4.0066 0.9669 27.0561
NCI-H1048 GDSC1 1.3655 4.5405 0.7638 28.3309
UMC-11 GDSC1 1.3819 4.9397 0.6173 29.114
NCI-H2110 GDSC1 1.3828 4.9891 0.5974 29.2248
COR-L105 GDSC1 1.4143 4.0154 1.0167 26.4521
NCI-H1563 GDSC1 1.4205 5.9048 0.2347 30.9868
NCI-H1993 GDSC1 1.4271 4.9463 0.6616 28.5981
SBC-1 GDSC1 1.4373 3.6635 1.1627 25.3594
NCI-H1915 GDSC1 1.4872 4.3033 0.9866 26.2366
NCI-H1650 GDSC1 1.4908 5.3179 0.5676 28.7932
NCI-H727 GDSC1 1.5127 5.8894 0.3348 29.9617
Lu-134-A GDSC1 1.5233 5.7161 0.4238 29.424
NCI-H2591 GDSC1 1.5258 5.4816 0.5312 28.8096
KNS-62 GDSC1 1.5308 5.1254 0.6927 27.8364
NCI-H2731 GDSC1 1.5456 6.555 0.0612 31.1649
NCI-H1975 GDSC1 1.5658 4.645 0.9326 26.1503
NCI-H2170 GDSC1 1.5729 4.4936 1.002 25.6613
NCI-H2291 GDSC1 1.5758 5.4471 0.5975 28.1551
NCI-H2369 GDSC1 1.6044 5.0049 0.8207 26.6498
NCI-H1623 GDSC1 1.6359 4.3358 1.1319 24.4567
Lu-139 GDSC1 1.6529 6.653 0.1209 30.3112
NCI-H2795 GDSC1 1.671 4.9477 0.9142 25.6983
NCI-H520 GDSC1 1.6713 4.5029 1.1019 24.465
NCI-H446 GDSC1 1.6901 4.1757 1.2523 23.3467
HCC827 GDSC1 1.7158 4.2929 1.2336 23.3357
NCI-H526 GDSC1 1.8059 3.8699 1.491 21.0708
SW1573 GDSC1 1.8276 5.381 0.8826 25.0774
ABC-1 GDSC1 1.851 5.0485 1.0551 23.8287
HOP-92 GDSC1 1.964 6.8236 0.3417 27.5937
NCI-H510A GDSC1 2.0089 5.1349 1.1769 22.2014
SBC-3 GDSC1 2.0508 4.1973 1.6262 18.817
NCI-H1355 GDSC1 2.0675 5.2222 1.196 21.7784
NCI-H2405 GDSC1 2.1028 5.1742 1.2534 21.2064
LOU-NH91 GDSC1 2.1408 5.3016 1.2327 21.1642
NCI-H146 GDSC1 2.1922 5.2029 1.3295 20.2351
NCI-H1666 GDSC1 2.2046 5.6882 1.1148 21.6695
NCI-H2087 GDSC1 2.2384 5.4173 1.2753 20.3957
Ms-1 GDSC1 2.2757 4.5672 1.702 17.1336
LK-2 GDSC1 2.287 4.9775 1.5278 18.3534
NCI-H358 GDSC1 2.2926 5.0343 1.5072 18.4773
NCI-H1869 GDSC1 2.3134 6.5543 0.8039 23.2041
NCI-H2444 GDSC1 2.3643 4.9728 1.6068 17.4081
SW1271 GDSC1 2.4088 5.0893 1.5965 17.2751
NCI-H2141 GDSC1 2.4662 5.497 1.4589 18.0201
NCI-H2227 GDSC1 2.4704 4.8815 1.7543 15.817
PaCa-3 GDSC1 2.4822 6.4014 1.0365 20.916
NCI-H1436 GDSC1 2.4827 4.93 1.7438 15.8381
ChaGo-K-1 GDSC1 2.4891 5.0645 1.6868 16.2341
NCI-H1963 GDSC1 2.4904 5.0021 1.7175 15.9997
Calu-3 GDSC1 2.4963 5.6525 1.4131 18.2163
DMS 114 GDSC1 2.5383 6.2924 1.142 19.947
EKVX GDSC1 2.5419 6.9256 0.8348 21.9756
NCI-H69 GDSC1 2.5834 4.5151 2.0362 13.1721
HCC15 GDSC1 2.6005 5.0207 1.8158 14.7596
DMS 79 GDSC1 2.6461 7.1532 0.8175 21.6317
NCI-H522 GDSC1 2.6776 8.458 0.199 25.1179
IST-SL1 GDSC1 2.6867 4.7817 2.0129 12.8753
NCI-H2595 GDSC1 2.6902 7.6878 0.5925 22.8358
NCI-H196 GDSC1 2.6957 6.8042 1.0349 19.992
NCI-H1694 GDSC1 2.7026 5.4553 1.7035 15.1563
NCI-H187 GDSC1 2.7331 5.9063 1.5113 16.4597
NCI-H2172 GDSC1 2.7426 5.6653 1.6383 15.4739
NCI-H3255 GDSC1 2.773 4.5388 2.2118 10.9682
RERF-LC-KJ GDSC1 2.7943 6.195 1.4251 16.8326
NCI-H2085 GDSC1 2.8196 4.7928 2.1351 11.3507
NCI-H650 GDSC1 2.8509 4.365 2.37 9.4076
NCI-H1573 GDSC1 2.8625 5.9167 1.6242 15.0751
NCI-H2342 GDSC1 2.8634 7.8389 0.6708 21.6358
IA-LM GDSC1 2.8823 6.7287 1.2396 17.7979
NCI-H1781 GDSC1 2.8927 5.9909 1.6148 15.0208
NCI-H596 GDSC1 2.9126 5.5452 1.8531 13.1306
NCI-H1838 GDSC1 2.9192 6.3115 1.4796 15.9171
NCI-H513 GDSC1 2.9219 5.7468 1.7618 13.7903
LC-2/ad GDSC1 2.9878 5.7869 1.801 13.2239
HCC366 GDSC1 3.088 6.0932 1.7368 13.3168
NCI-H810 GDSC1 3.0902 5.1785 2.1941 9.7678
NCI-H226 GDSC1 3.1062 5.8138 1.8919 12.0565
NCI-H441 GDSC1 3.1246 6.5841 1.5236 14.776
COR-L88 GDSC1 3.206 8.586 0.5927 20.7485
NCI-H1770 GDSC1 3.2733 4.3169 2.7833 4.4271
NCI-H2722 GDSC1 3.2967 8.211 0.8563 18.7574
COR-L279 GDSC1 3.3372 5.7247 2.1332 9.3114
COR-L321 GDSC1 3.3475 6.3205 1.8439 11.5191
NCI-H1581 GDSC1 3.3939 5.1621 2.4611 6.5324
NCI-H2228 GDSC1 3.4036 6.2358 1.9325 10.6353
NCI-H1304 GDSC1 3.4916 5.5373 2.3522 7.0532
NCI-H2081 GDSC1 3.499 5.8296 2.2124 8.1236
NCI-H835 GDSC1 3.506 6.6629 1.8022 11.2751
NCI-H2869 GDSC1 3.5584 10.8823 -0.263 24.0488
NCI-H1688 GDSC1 3.5849 8.0477 1.1745 15.5771
NCI-H2066 GDSC1 3.5947 5.6815 2.3611 6.644
NCI-H2029 GDSC1 3.8825 5.5632 2.627 3.7519
NCI-H211 GDSC1 3.9519 5.9013 2.5119 4.4341
COR-L95 GDSC1 4.0034 7.5782 1.7316 10.1824
NCI-H1092 GDSC1 4.0098 7.6398 1.706 10.3518
COLO 668 GDSC1 4.0111 6.2304 2.3943 5.1624
SHP-77 GDSC1 4.1546 5.5673 2.7937 1.9455
DMS 53 GDSC1 4.1693 7.2541 2.0094 7.6233
NCI-H345 GDSC1 4.2031 7.1143 2.1004 6.8515
NCI-H1435 GDSC1 4.5267 7.4667 2.1469 5.6868
NCI-H322M GDSC1 4.5416 11.5578 0.171 18.6031
Lu-165 GDSC1 4.9272 6.6589 2.7258 1.2079
NCI-H1836 GDSC1 5.1182 7.226 2.5859 1.7145
Lu-65 GDSC1 5.4019 7.1463 2.7432 0.6974
NCI-H2135 GDSC1 5.7286 7.1738 2.8576 0.2091
⏷ Show the Full List of 176 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 2.1308 5.2552 1.2442 21.133
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 GDSC1 -2.2623 2.3592 -2.539 64.3476
TE-10 GDSC1 -0.7613 1.8031 -0.8299 50.9752
OE21 GDSC1 -0.7428 3.6589 -1.2104 50.6153
TE-4 GDSC1 -0.3804 2.3703 -0.5042 46.5746
KYSE-180 GDSC1 -0.1526 2.2025 -0.2333 43.7506
OE33 GDSC1 -0.0484 3.7064 -0.468 43.5348
TE-11 GDSC1 -0.0352 1.4771 -0.0456 42.0195
TE-5 GDSC1 0.107 4.4358 -0.5434 42.505
KYSE-510 GDSC1 0.4405 2.9407 0.2726 36.9486
TE-8 GDSC1 0.7996 2.8684 0.6785 32.2754
EC-GI-10 GDSC1 0.8481 7.313 -0.9821 38.8809
KYSE-150 GDSC1 1.0422 4.081 0.592 31.2638
KYSE-410 GDSC1 1.2222 4.3721 0.6774 29.6833
TE-15 GDSC1 1.3731 3.4748 1.1515 25.8036
KYSE-270 GDSC1 1.4092 3.8369 1.0742 26.1053
OE19 GDSC1 1.6394 5.2255 0.7606 26.834
KYSE-450 GDSC1 1.7593 4.9436 1.0071 24.6254
TE-9 GDSC1 2.0102 4.7858 1.334 21.1028
KYSE-520 GDSC1 2.0295 4.651 1.4127 20.4491
TE-6 GDSC1 2.3353 5.8538 1.1624 20.7273
T.T GDSC1 2.4109 6.5494 0.8978 22.155
TE-1 GDSC1 2.6786 11.0067 -1.0689 30.6753
KYSE-70 GDSC1 2.6933 6.9019 0.9844 20.3411
COLO 680N GDSC1 3.1867 7.2187 1.2597 16.447
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-21G GDSC1 -1.7563 1.4746 -1.8465 61.6885
EFO-27 GDSC1 -0.6982 2.4512 -0.862 50.2226
OC 314 GDSC1 -0.6783 1.4649 -0.71 50.0023
OVCAR-5 GDSC1 -0.563 2.043 -0.6494 48.6569
OVK18 GDSC1 -0.5594 3.0559 -0.8443 48.7565
TYK-nu GDSC1 -0.4625 2.6697 -0.65 47.6132
OVISE GDSC1 -0.2308 3.36 -0.5657 45.3074
TOV-112D GDSC1 -0.0985 4.532 -0.7994 44.6587
ES-2 GDSC1 -0.0612 2.3905 -0.1639 42.7249
A2780 GDSC1 -0.0249 3.247 -0.3104 42.9047
DOV13 GDSC1 0.0932 2.7389 -0.0613 41.0725
OV-90 GDSC1 0.4358 5.1099 -0.4479 39.8691
OV56 GDSC1 0.5028 2.848 0.3606 36.0538
OVTOKO GDSC1 0.5788 5.139 -0.3084 38.4393
IGROV-1 GDSC1 0.6272 5.7962 -0.5311 38.8733
OVCAR-4 GDSC1 0.9551 5.9345 -0.2525 35.8611
FU-OV-1 GDSC1 1.2308 5.7383 0.1163 32.6392
OVCAR-8 GDSC1 1.3952 3.0962 1.2763 24.8521
OVCAR-3 GDSC1 1.4177 5.4905 0.4168 30.0444
SK-OV-3 GDSC1 1.4448 4.6669 0.7964 27.6817
OAW28 GDSC1 1.4637 4.9368 0.7038 28.1411
JHOS-2 GDSC1 1.5831 3.9941 1.2061 24.2477
Kuramochi GDSC1 1.8114 4.5348 1.2356 22.8121
EFO-21 GDSC1 2.3906 5.6292 1.3231 19.3447
RMG-I GDSC1 2.6904 7.4586 0.7063 22.1411
OAW42 GDSC1 2.8271 6.7015 1.2039 18.2762
Caov-4 GDSC1 2.8505 5.7057 1.7175 14.4222
JHOS-4 GDSC1 3.295 5.5659 2.1774 9.1184
OVKATE GDSC1 4.3497 11.2639 0.1716 19.1915
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 03.27 GDSC1 -0.2982 1.0941 -0.3024 45.2704
Panc 04.03 GDSC1 0.1554 4.257 -0.4278 41.8211
HPAC GDSC1 0.1604 5.1477 -0.755 42.6321
AsPC-1 GDSC1 0.2916 2.8418 0.1325 38.7081
DAN-G GDSC1 0.3472 4.9676 -0.4857 40.5971
PaTu 8988t GDSC1 0.4583 3.5163 0.1416 37.4582
MZ-PC-1 GDSC1 0.6041 6.4883 -0.8558 39.9655
PL4 GDSC1 0.6864 3.7484 0.3189 35.0251
PaTu 8902 GDSC1 0.7667 4.1968 0.2535 34.8231
PSN1 GDSC1 0.7854 3.7757 0.4177 33.8547
CFPAC-1 GDSC1 0.9181 4.7818 0.1937 34.145
HPAF-II GDSC1 1.0363 4.3196 0.4984 31.8293
HuP-T3 GDSC1 1.1599 4.0772 0.7203 29.7956
Panc 10.05 GDSC1 1.3239 5.7932 0.1869 31.7657
KP-4 GDSC1 1.3244 3.8049 0.9932 27.1213
MIA PaCa-2 GDSC1 1.4127 4.7531 0.7273 28.2851
Hs 766T GDSC1 1.4956 6.7997 -0.1024 32.1874
HuP-T4 GDSC1 1.5258 6.8232 -0.0837 31.9439
BxPC-3 GDSC1 1.5975 6.5988 0.0919 30.7429
SW1990 GDSC1 1.8739 5.0786 1.0652 23.6438
Panc 02.03 GDSC1 1.8924 4.4093 1.3727 21.4363
Panc 08.13 GDSC1 1.9294 5.004 1.1549 22.7538
SUIT-2 GDSC1 1.9438 4.8379 1.2429 22.0756
YAPC GDSC1 2.2112 5.1168 1.3881 19.7261
SU.86.86 GDSC1 2.3688 6.3351 0.9624 21.9244
KP-1N GDSC1 2.4525 4.7317 1.8059 15.5156
KP-3 GDSC1 3.0147 5.2159 2.1081 10.7412
KP-2 GDSC1 3.3492 5.1379 2.4366 6.8836
Capan-1 GDSC1 3.7702 6.6758 2.0024 8.8644
QGP-1 GDSC1 4.0934 7.1921 1.986 8.0138
Capan-2 GDSC1 5.1296 7.3275 2.5497 1.8995
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1 0.4085 3.3366 0.1384 37.8288
MPP 89 GDSC1 0.867 3.5663 0.5723 32.4714
NCI-H2452 GDSC1 1.101 3.7003 0.7852 29.7559
MSTO-211H GDSC1 1.6372 3.8269 1.3243 23.1453
IST-Mes1 GDSC1 1.8383 5.51 0.8348 25.3262
NCI-H2052 GDSC1 1.8898 5.2108 1.0221 23.8489
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 0.268 2.6199 0.1511 38.7937
LNCaP clone FGC GDSC1 0.5878 3.9666 0.1401 36.5621
PC-3 GDSC1 1.8027 4.6473 1.1793 23.2427
22Rv1 GDSC1 2.1194 4.3209 1.6471 18.3139
VCaP GDSC1 2.205 13.4424 -2.6968 36.8825
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 0.4149 4.483 -0.2291 39.2783
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-mel GDSC1 -1.431 0.0325 -1.432 59.3547
IST-MEL1 GDSC1 -1.0221 1.8037 -1.107 53.9296
IGR-37 GDSC1 -1.0104 1.6933 -1.0811 53.8408
IPC-298 GDSC1 -0.8679 1.7479 -0.9364 52.2131
WM793 GDSC1 -0.6713 2.5754 -0.8572 49.9262
CHL-1 GDSC1 -0.4805 1.6398 -0.5173 47.6075
COLO 679 GDSC1 -0.4652 4.082 -1.0411 48.013
A-375 GDSC1 -0.2468 1.504 -0.2646 44.6828
HT-144 GDSC1 -0.1151 2.9383 -0.3316 43.729
RPMI-7951 GDSC1 -0.0446 2.5199 -0.1683 42.6023
LOX-IMVI GDSC1 0.171 3.1094 -0.0612 40.4615
SK-MEL-2 GDSC1 0.1891 3.7806 -0.2324 40.9495
A2058 GDSC1 0.3493 2.9349 0.1747 38.0859
WM278 GDSC1 0.3797 2.9959 0.1938 37.7733
A-431 GDSC1 0.4561 2.4596 0.3806 36.2639
IGR-1 GDSC1 0.5826 2.3214 0.5344 34.5343
451Lu GDSC1 0.6548 4.0025 0.2005 35.8229
SK-MEL-5 GDSC1 0.7075 3.6568 0.3707 34.6166
MeWo GDSC1 0.7693 4.2747 0.2282 34.9295
Mel Ho GDSC1 0.845 3.1775 0.6568 32.1174
G-361 GDSC1 0.8591 3.9541 0.4384 33.2681
A-388 GDSC1 0.9145 4.6618 0.2373 33.9551
A101D GDSC1 0.9218 4.6118 0.2645 33.7737
Mel JuSo GDSC1 1.0059 2.8748 0.901 29.613
CP50-MEL-B GDSC1 1.0212 8.1857 -1.2187 38.5737
SK-MEL-30 GDSC1 1.0612 3.9975 0.6421 30.8568
COLO 800 GDSC1 1.0918 3.4891 0.8405 29.4686
WT2-iPS GDSC1 1.1222 6.6551 -0.4063 35.48
SK-MEL-28 GDSC1 1.227 5.5597 0.1908 32.3003
SH-4 GDSC1 1.2506 3.9111 0.877 28.2935
DJM-1 GDSC1 1.317 3.8401 0.9732 27.2933
COLO 829 GDSC1 1.5029 4.8428 0.7843 27.4322
RVH-421 GDSC1 1.5806 5.7376 0.472 28.8461
UACC-62 GDSC1 1.606 4.908 0.8639 26.3691
M14 GDSC1 1.6583 4.287 1.1749 24.0454
WM1552C GDSC1 1.6969 6.8699 0.0615 30.3743
Hs 938.T GDSC1 1.7579 6.153 0.4582 27.9885
COLO 792 GDSC1 1.7708 3.6516 1.5288 21.0023
HMV-II GDSC1 1.923 5.2421 1.0416 23.5501
WM115 GDSC1 2.0262 5.4626 1.0444 23.0135
GAK GDSC1 2.1036 4.6841 1.4744 19.6363
SK-MEL-24 GDSC1 2.1775 5.0871 1.3681 20.0323
Hs 940.T GDSC1 2.2369 5.5485 1.2122 20.8449
LB2518-MEL GDSC1 2.2657 5.7659 1.1374 21.2253
WM35 GDSC1 2.2844 6.0766 1.0069 22.0203
SK-MEL-31 GDSC1 2.3534 7.4997 0.3796 25.5484
MZ-MEL-2 GDSC1 2.3828 5.008 1.6089 17.3056
MZ-MEL-7 GDSC1 2.5958 5.2774 1.6885 15.7386
VMRC-MELG GDSC1 2.7142 6.8254 1.0411 19.8713
SK-MEL-3 GDSC1 3.0201 5.8934 1.7767 13.2803
CP66-MEL GDSC1 3.1087 6.723 1.4406 15.4484
MMAc-SF GDSC1 3.1607 5.9333 1.8796 11.9413
UACC-257 GDSC1 3.3806 5.153 2.4548 6.6288
LB373-MEL-D GDSC1 3.6777 6.7494 1.8949 9.9864
SK-MEL-1 GDSC1 3.874 7.0655 1.8879 9.4105
EquiPSC Line K2 GDSC1 2.8683 8.0051 0.5924 22.092
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 0.0418 2.2005 -0.0256 41.33
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1080 GDSC1 -1.0963 0.6152 -1.1016 55.1637
Hs 633.T GDSC1 -0.8179 1.135 -0.8346 51.7093
KYM-1 GDSC1 -0.5871 2.3058 -0.7158 48.9671
VA-ES-BJ GDSC1 -0.545 2.2769 -0.6657 48.4788
G-402 GDSC1 -0.5167 3.4698 -0.9086 48.3838
SW982 GDSC1 -0.3065 3.0209 -0.5599 45.9779
MFH-ino GDSC1 -0.2197 1.8004 -0.258 44.4224
Rh30 GDSC1 -0.0971 2.2394 -0.1792 43.0834
EW-8 GDSC1 0.0583 1.5053 0.0491 40.8464
STS-0421 GDSC1 0.273 3.9599 -0.1992 40.2002
A-204 GDSC1 0.2806 4.5694 -0.4054 40.8272
SW872 GDSC1 0.3682 2.9173 0.1992 37.83
SK-UT-1 GDSC1 0.4524 1.9087 0.4352 35.9738
SK-LMS-1 GDSC1 0.6453 2.9025 0.5037 34.3016
GCT GDSC1 0.7298 3.3634 0.4816 33.8691
Rh41 GDSC1 1.2177 2.6909 1.162 26.657
RKN GDSC1 1.2755 4.0021 0.8719 28.1797
MES-SA GDSC1 2.0826 4.7608 1.419 20.1374
G-401 GDSC1 2.0868 4.506 1.5346 19.2892
RD GDSC1 2.6161 4.6445 2.0086 13.2288
Rh18 GDSC1 2.7503 5.4623 1.7447 14.639
SW684 GDSC1 3.1797 5.3075 2.2082 9.3089
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-5 GDSC1 -0.4246 4.9604 -1.3074 47.8686
HSC-39 GDSC1 -0.4126 1.1912 -0.4213 46.7103
OCUM-1 GDSC1 -0.1086 4.5667 -0.8229 44.781
23132/87 GDSC1 0.0137 3.554 -0.3544 42.7185
HGC-27 GDSC1 0.0501 2.1124 -0.0057 41.1753
MKN45 GDSC1 0.1341 3.6583 -0.2544 41.4486
NUGC-3 GDSC1 0.4813 2.3945 0.417 35.8883
AGS GDSC1 0.4931 3.379 0.219 36.8459
GCIY GDSC1 0.5825 4.1609 0.0674 36.9257
TGBC11TKB GDSC1 1.0068 5.207 0.1135 33.9778
SCH GDSC1 1.0431 4.2939 0.5153 31.6935
NCI-N87 GDSC1 1.1873 6.3445 -0.1995 34.2951
Hs 746.T GDSC1 1.3462 6.2911 -0.0154 32.6034
KATO III GDSC1 1.4276 4.2817 0.9313 26.9285
TMK-1 GDSC1 1.5226 4.8682 0.7941 27.2622
SK-GT-2 GDSC1 1.7416 7.7129 -0.2981 31.7816
IM95 GDSC1 1.7894 5.2463 0.9044 25.1362
MKN1 GDSC1 1.7985 4.0528 1.4151 21.6387
MKN7 GDSC1 1.8662 6.0811 0.5986 26.6267
ECC10 GDSC1 1.8793 4.5176 1.3138 21.9155
Fu97 GDSC1 2.0236 4.6115 1.4237 20.4009
RF-48 GDSC1 2.4155 6.6865 0.8352 22.5379
NUGC-4 GDSC1 2.4945 6.663 0.9201 21.6338
SNU-16 GDSC1 2.5928 6.1902 1.2425 19.0066
RERF-GC-1B GDSC1 2.6325 7.2041 0.7801 21.9279
MKN28 GDSC1 2.8542 4.9556 2.0887 11.5596
SNU-1 GDSC1 4.5899 7.5175 2.1632 5.4221
SNG-M GDSC1 -3.3628 1.5485 -3.5768 72.5904
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 -0.8364 1.2158 -0.8579 51.925
K5 GDSC1 -0.2183 2.0349 -0.2813 44.4879
FTC-133 GDSC1 0.0423 3.2187 -0.2295 42.0967
CAL-62 GDSC1 0.4731 2.3927 0.4086 35.9909
HTC-C3 GDSC1 0.517 4.4349 -0.1017 38.0838
B-CPAP GDSC1 0.5442 3.2938 0.2982 36.0956
KMH-2 GDSC1 0.6004 2.6708 0.501 34.6134
CGTH-W-1 GDSC1 0.898 3.4161 0.6504 31.8199
ML-1 [Human leukemia] GDSC1 0.9976 5.7162 -0.1134 35.0412
BHT-101 GDSC1 1.0539 3.217 0.8746 29.4859
TT2609-C02 GDSC1 1.0974 4.6102 0.4519 31.7134
8505C GDSC1 1.2194 4.3554 0.6808 29.6798
ASH-3 GDSC1 1.8466 4.2832 1.3759 21.6551
8305C GDSC1 1.8854 6.8764 0.2409 28.5195
WRO GDSC1 2.0012 5.1316 1.1705 22.2843
TT GDSC1 5.0152 14.003 -0.6815 21.3752
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-06A GDSC1 -3.641 -1.8509 -3.6413 84.5245
KON GDSC1 -1.7152 5.1325 -2.7578 57.2933
BICR 10 GDSC1 -0.8881 1.6599 -0.948 52.463
PCI-38 GDSC1 -0.8757 1.8649 -0.9591 52.2776
BB30-HNC GDSC1 -0.7345 1.7433 -0.7947 50.6662
BICR 22 GDSC1 -0.6315 3.1988 -0.9595 49.5243
JHU-011 GDSC1 -0.4321 1.801 -0.4815 47.0446
HSC-4 GDSC1 -0.3495 1.6705 -0.3828 46.0001
SKN-3 GDSC1 -0.15 3.1652 -0.4254 44.2833
Detroit 562 GDSC1 -0.1064 2.7545 -0.2813 43.5047
PCI-04B GDSC1 -0.0588 3.1417 -0.3199 43.2157
JHU-022 GDSC1 -0.0581 3.1866 -0.3308 43.2422
Ca9-22 GDSC1 0.0202 2.0025 -0.0251 41.4972
HO-1-u-1 GDSC1 0.1078 2.1909 0.046 40.4932
HO-1-N-1 GDSC1 0.2404 3.6637 -0.1403 40.2315
NCI-H3118 GDSC1 0.3775 3.1164 0.1623 37.941
BICR 78 GDSC1 0.4325 4.003 -0.0406 38.4329
SAS GDSC1 0.4595 2.5948 0.3623 36.3418
CAL-33 GDSC1 0.4874 2.6127 0.3893 36.002
KOSC-2 GDSC1 0.5136 2.7448 0.3932 35.8023
FaDu GDSC1 0.5682 3.3047 0.3214 35.8118
PCI-15A GDSC1 0.7388 2.5158 0.675 32.6834
LB771-HNC GDSC1 0.7538 5.4534 -0.2541 37.1057
OSC-20 GDSC1 0.9449 5.6053 -0.12 35.3873
DOK GDSC1 1.1802 5.5874 0.1306 32.8639
SAT [Human HNSCC] GDSC1 1.2604 3.6942 0.9605 27.7053
OSC-19 GDSC1 1.2769 4.7458 0.5874 29.8901
BB49-HNC GDSC1 1.4154 6.2084 0.0918 31.7203
PCI-30 GDSC1 1.4789 5.5674 0.4453 29.5484
JHU-029 GDSC1 1.5313 4.2491 1.0546 25.546
SCC-4 GDSC1 1.6075 8.2074 -0.6639 33.881
SCC-25 GDSC1 1.8213 5.515 0.8154 25.5363
HSC-2 GDSC1 1.8922 3.7997 1.6093 19.7775
PE/CA-PJ15 GDSC1 2.0537 4.6691 1.4297 20.2067
BHY GDSC1 2.0828 6.2022 0.7529 24.6176
HSC-3 GDSC1 2.0882 3.4841 1.928 16.4854
SCC-15 GDSC1 2.1527 15.1986 -3.6169 38.7032
CAL-27 GDSC1 2.1961 5.0516 1.4029 19.6933
UPCI-SCC-090 GDSC1 2.4324 5.8986 1.2337 19.7848
SCC-9 GDSC1 2.7915 5.523 1.7532 14.3992
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1 -1.6232 0.2488 -1.6284 61.5555
RT-112 GDSC1 -0.8318 2.4489 -1.0061 51.6739
TCCSUP GDSC1 -0.2787 3.7302 -0.7262 46.0164
CAL-29 GDSC1 -0.2716 2.4242 -0.3962 45.3007
5637 GDSC1 -0.1597 2.0521 -0.2211 43.7691
T24 GDSC1 0.4592 1.896 0.443 35.8833
SW1710 GDSC1 0.4892 3.2275 0.2558 36.6913
647V GDSC1 0.8222 2.7194 0.7316 31.8091
UM-UC-3 GDSC1 0.9964 3.8565 0.6203 31.3823
SW780 GDSC1 1.0475 4.3281 0.5072 31.7119
BFTC-905 GDSC1 1.0944 4.3262 0.5582 31.1398
J82 GDSC1 1.3927 4.9108 0.6407 28.9155
HT-1376 GDSC1 1.7272 6.1198 0.4433 28.2307
639V GDSC1 2.0037 4.516 1.444 20.3582
HT-1197 GDSC1 2.7176 6.4301 1.2394 18.4884
RT-4 GDSC1 3.5967 8.3829 1.0166 16.6073
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEY GDSC1 -1.161 0.9674 -1.1798 55.8382
SW954 GDSC1 -1.1216 1.8162 -1.2147 55.0058
NEC8 GDSC1 -1.0661 0.4039 -1.068 54.8251
C-33 A GDSC1 -0.6373 2.1437 -0.7436 49.5318
PA-1 GDSC1 -0.4188 1.7975 -0.4671 46.8812
PWR-1E GDSC1 -0.3104 1.5037 -0.3304 45.4781
C-4-I GDSC1 -0.2178 1.9712 -0.2733 44.4575
KGN GDSC1 0.1185 2.3171 0.0402 40.4389
PEO1 GDSC1 0.1573 3.0297 -0.0565 40.549
Ca Ski GDSC1 0.217 3.8283 -0.2173 40.6853
HT-3 GDSC1 0.2536 2.0164 0.2193 38.549
OVMIU GDSC1 0.3325 4.4282 -0.2977 40.1048
JAR GDSC1 0.4246 1.762 0.4142 36.2801
SiSo GDSC1 0.4298 2.7963 0.2921 36.923
SKN GDSC1 0.4452 4.7415 -0.2938 39.2946
ME-180 GDSC1 0.4488 6.7481 -1.1296 41.5777
DSH1 GDSC1 0.7505 3.9227 0.3313 34.5372
NT2-D1 GDSC1 0.7525 3.2161 0.546 33.3578
DoTc2 4510 GDSC1 0.8559 3.0509 0.6995 31.7918
SW962 GDSC1 0.8671 3.9506 0.4482 33.1636
CAL-39 GDSC1 0.9376 4.0552 0.4883 32.498
TC-YIK GDSC1 0.961 2.8723 0.8527 30.1933
BPH-1 GDSC1 1.0741 4.3413 0.5308 31.4178
SW756 GDSC1 1.1546 3.9073 0.7744 29.4994
JEG-3 GDSC1 1.3785 3.084 1.2609 25.052
OV17R GDSC1 1.4455 5.9832 0.2245 30.9004
HeLa GDSC1 1.4546 3.9848 1.0712 25.8664
MS751 GDSC1 1.5913 4.4923 1.0218 25.4307
OVCA433 GDSC1 1.5998 4.5801 0.995 25.5594
HEC-1 GDSC1 1.6383 3.8951 1.3013 23.2966
ACC-OV7 GDSC1 1.7408 7.6889 -0.2872 31.739
LB831-BLC GDSC1 2.2397 6.153 0.9274 22.7542
OMC-1 [Human cervical carcinoma] GDSC1 2.3687 4.9819 1.607 17.3855
OVCA420 GDSC1 2.3866 5.1919 1.5266 17.8923
UWB1.289 GDSC1 2.8063 7.1031 0.9861 19.8515
SKG-IIIa GDSC1 3.0897 6.1558 1.7071 13.536
JHOS-3 GDSC1 3.1446 6.6592 1.5033 14.8483
SiHa GDSC1 3.4521 5.6418 2.2686 7.8438
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14;56(5):2125-38.