Details of the Drug

General Information of Drug (ID: DMNU2MH)

Drug Name
Tandutinib
Synonyms
CT 53518; CT53518; MLN 518; CT-53518; MLN-0518; MLN-518; MLN518, CT53518; Tandutinib (USAN/INN); (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide; 4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide; 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
Indication
Disease Entry ICD 11 Status REF
Anaplastic mixed oligoastrocytoma 2A00.0Y Discontinued in Phase 2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 562.7
Logarithm of the Partition Coefficient (xlogp) 4.6
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C31H42N6O4
IUPAC Name
4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
Canonical SMILES
CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5
InChI
InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
InChIKey
UXXQOJXBIDBUAC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3038522
ChEBI ID
CHEBI:90237
CAS Number
387867-13-2
UNII
E1IO3ICJ9A
DrugBank ID
DB05465
TTD ID
D0IT6Q
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fms-like tyrosine kinase 3 (FLT-3) TTGJCWZ FLT3_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Anaplastic mixed oligoastrocytoma
ICD Disease Classification 2A00.0Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Fms-like tyrosine kinase 3 (FLT-3) DTT FLT3 2.11E-01 -0.05 -0.16
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 3.1579 5.1738 3.0822 19.4877
JM1 CTRP2 2.3705 4.0215 2.3592 24.5138
EoL-1 CTRP2 -10.3908 -5.7594 -10.3925 94.2315
MOLM-13 CTRP2 -3.5988 -0.492 -3.6019 64.0452
MV4-11 CTRP2 -2.9683 0.5553 -2.9798 59.8315
Kasumi-1 CTRP2 -0.9225 3.2408 -1.016 46.5503
SEM CTRP2 -0.9028 3.8238 -1.0667 46.5059
MOLT-3 CTRP2 1.3385 1.9608 1.3385 31.3512
697 CTRP2 1.3609 2.1539 1.3609 31.2023
SUP-M2 CTRP2 1.3933 2.5343 1.3931 30.9869
A3/Kawakami CTRP2 1.4883 2.0227 1.4883 30.3531
OCI-Ly19 CTRP2 1.591 7.3877 0.7609 32.3325
OPM-2 CTRP2 1.6458 2.4801 1.6458 29.3043
GA-10 CTRP2 1.7494 2.483 1.7494 28.6138
CA46 CTRP2 1.792 2.9385 1.7917 28.3313
EB1 CTRP2 1.8135 2.9106 1.8133 28.1873
Pfeiffer CTRP2 1.8371 3.335 1.8342 28.0392
Hs 611.T CTRP2 1.8661 3.878 1.8472 27.8994
Namalwa CTRP2 1.9773 2.9566 1.9772 27.0958
LP-1 CTRP2 2.0625 4.0903 2.0382 26.6093
Daudi CTRP2 2.1344 3.4076 2.133 26.0535
OCI-Ly10 CTRP2 2.1948 6.678 1.6546 27.5077
Granta-519 CTRP2 2.236 5.1607 2.0918 25.8635
AML-193 CTRP2 2.3445 3.8711 2.3378 24.6715
A4/Fukuda CTRP2 2.3548 3.3342 2.3545 24.5815
SUP-B15 CTRP2 2.3993 3.8062 2.395 24.2984
OCI-AML-3 CTRP2 2.4439 3.3317 2.4438 23.9875
JJN-3 CTRP2 2.4574 3.8738 2.4524 23.9138
M-07e CTRP2 2.495 3.9468 2.4889 23.667
MOTN-1 CTRP2 2.5114 4.131 2.4993 23.5781
KMS-20 CTRP2 2.5127 3.4442 2.5125 23.5295
Mino CTRP2 2.5171 3.167 2.5171 23.4993
Kasumi-2 CTRP2 2.5268 3.2179 2.5268 23.435
CMK CTRP2 2.5344 3.5894 2.5338 23.3861
SET-2 CTRP2 2.5898 3.2299 2.5898 23.0151
MOLP-8 CTRP2 2.594 4.2655 2.5779 23.041
BCP-1 CTRP2 2.594 4.3056 2.5757 23.0483
ST486 CTRP2 2.605 3.2998 2.6049 22.9141
OCI-AML-5 CTRP2 2.6075 3.1902 2.6075 22.897
DND-41 CTRP2 2.6223 3.9637 2.6178 22.8137
K-562 CTRP2 2.6288 3.3787 2.6287 22.7554
KO52 CTRP2 2.6449 3.217 2.6449 22.6477
DB CTRP2 2.6569 3.8205 2.6551 22.5739
NU-DHL-1 CTRP2 2.6833 4.0487 2.6778 22.4105
HuT 78 CTRP2 2.7115 4.4023 2.6915 22.2714
SIG-M5 CTRP2 2.7118 3.1749 2.7118 22.2022
JeKo-1 CTRP2 2.7234 4.0904 2.7175 22.1447
BL-70 CTRP2 2.7555 3.4529 2.7555 21.9112
Ku812 CTRP2 2.8621 5.8239 2.6291 22.0093
HEL 92.1.7 CTRP2 2.8642 4.4958 2.844 21.2545
Ci-1 CTRP2 2.8674 4.8516 2.8154 21.3415
NCO2 CTRP2 2.9538 4.4519 2.9393 20.6383
HuNS1 CTRP2 2.9928 6.6986 2.515 22.0246
EJM CTRP2 3.1643 7.3379 2.4729 21.678
Mono-Mac-1 CTRP2 3.184 14.3396 -0.6752 31.3412
U266B1 CTRP2 3.2765 4.9416 3.2382 18.5692
NALM-6 CTRP2 3.3308 5.6676 3.1767 18.6105
Karpas-422 CTRP2 3.3456 5.9636 3.1208 18.7636
RL CTRP2 3.3627 4.9229 3.3309 17.9729
CML-T1 CTRP2 3.3739 4.4943 3.3685 17.809
ALL-SIL CTRP2 3.4168 4.3296 3.4153 17.5106
Peer CTRP2 3.496 4.7156 3.4848 17.0154
OCI-Ly3 CTRP2 3.6549 6.8177 3.191 17.5869
MOLM-6 CTRP2 3.6567 5.4063 3.581 16.1652
HD-MY-Z CTRP2 3.6574 5.3073 3.5973 16.1068
F-36P CTRP2 3.6637 5.6044 3.5519 16.2448
BV-173 CTRP2 3.6972 6.3481 3.3939 16.711
L-428 CTRP2 3.705 5.3221 3.6461 15.7854
MJ CTRP2 3.7602 6.2402 3.4955 16.1508
TF-1 CTRP2 3.7956 5.8125 3.6495 15.4878
RPMI-8402 CTRP2 3.8767 5.4163 3.8159 14.6485
JURL-MK1 CTRP2 3.886 5.2883 3.8441 14.5214
KMS-21-BM CTRP2 3.9059 5.4253 3.8459 14.4512
SUP-HD1 CTRP2 3.9607 7.4495 3.2767 16.4007
L-363 CTRP2 3.9777 5.8511 3.8386 14.2509
OCI-AML-2 CTRP2 3.9923 5.8744 3.8489 14.1692
PF-382 CTRP2 4.006 5.4166 3.9544 13.7553
HL-60 CTRP2 4.0094 6.0369 3.8255 14.2005
KMS-34 CTRP2 4.0404 5.3412 4.0016 13.4824
NCI-H929 CTRP2 4.0459 5.5191 3.981 13.5357
KYO-1 CTRP2 4.0635 5.7178 3.9623 13.5454
KMS-26 CTRP2 4.0645 4.867 4.0613 13.2013
KE-97 CTRP2 4.0926 6.2512 3.8545 13.8442
KE-37 CTRP2 4.1384 4.913 4.1352 12.7086
KMS-11 CTRP2 4.1958 6.0028 4.0381 12.8661
NU-DUL-1 CTRP2 4.2135 5.5262 4.1602 12.3794
RS4;11 CTRP2 4.2491 5.914 4.1191 12.4122
Mono-Mac-6 CTRP2 4.2781 25.6766 -5.2799 36.2987
MOLT-16 CTRP2 4.2809 5.4509 4.2434 11.8757
SUP-T11 CTRP2 4.3 5.426 4.267 11.7331
TALL-1 [Human adult T-ALL] CTRP2 4.3554 5.9221 4.2331 11.6771
SUP-T1 CTRP2 4.357 6.2628 4.1389 12.0139
OCI-M1 CTRP2 4.4016 5.7892 4.3143 11.2455
Karpas-299 CTRP2 4.4018 6.3614 4.1562 11.8174
L-540 CTRP2 4.4116 5.5506 4.369 11.0227
P12-Ichikawa CTRP2 4.4172 5.5434 4.376 10.9807
MOLM-16 CTRP2 4.4319 7.1014 3.9149 12.6465
DEL CTRP2 4.4403 4.8766 4.4402 10.6869
GDM-1 CTRP2 4.4524 7.9221 3.587 13.8767
EM-2 CTRP2 4.4792 5.6998 4.4165 10.6425
KMS-12-BM CTRP2 4.5067 5.9616 4.3882 10.6568
SR CTRP2 4.5938 6.1812 4.4219 10.2707
P31/FUJ CTRP2 4.686 5.8306 4.6144 9.2967
SU-DHL-6 CTRP2 4.7065 7.3029 4.1186 11.1125
HDLM-2 CTRP2 4.7245 6.6695 4.3955 9.9905
MOLT-13 CTRP2 4.7967 7.1748 4.2669 10.2911
LAMA-84 CTRP2 4.8242 8.2754 3.7999 12.0863
Jurkat CTRP2 4.8314 6.5923 4.539 9.1432
SU-DHL-1 CTRP2 4.8567 5.9987 4.7604 8.2484
WSU-DLCL2 CTRP2 4.8999 5.8604 4.8404 7.8299
HT CTRP2 5.0178 6.0957 4.9096 7.2194
PL21 CTRP2 5.0907 6.3007 4.9238 6.9517
RCH-ACV CTRP2 5.1074 6.7307 4.7777 7.4622
U-937 CTRP2 5.1084 6.2053 4.9749 6.7101
AMO1 CTRP2 5.1353 7.5096 4.4634 8.6371
KMS-27 CTRP2 5.1734 6.4809 4.9471 6.6279
SU-DHL-8 CTRP2 5.2826 8.4059 4.1812 9.4371
HPB-ALL CTRP2 5.3122 7.0604 4.8459 6.6558
THP-1 CTRP2 5.3437 6.3221 5.1892 5.2273
RPMI-8226 CTRP2 5.3516 7.5814 4.6428 7.3806
SKM-1 CTRP2 5.424 6.4801 5.2133 4.9111
KM-H2 CTRP2 5.4787 8.9127 4.1153 9.2702
KCL-22 CTRP2 5.5967 8.9811 4.1881 8.7115
MOLP-2 CTRP2 5.6071 7.0338 5.1506 4.6956
RPMI-6666 CTRP2 5.7129 7.5676 4.9915 5.1102
Ki-JK CTRP2 5.7978 8.1282 4.7905 5.7666
MHH-CALL-3 CTRP2 5.8545 7.3201 5.2421 3.7578
Ri-1 CTRP2 5.8598 8.7773 4.5212 6.768
MM1.S CTRP2 5.8671 8.3091 4.7611 5.7466
SU-DHL-10 CTRP2 5.8817 9.6586 4.1 8.4907
Karpas-620 CTRP2 5.8951 7.9672 4.9559 4.8718
KMS-18 CTRP2 6.0895 7.7934 5.2072 3.4326
ME1 CTRP2 6.4215 9.324 4.7073 4.9334
MC116 CTRP2 6.8606 14.3472 2.5521 12.9607
MHH-CALL-4 CTRP2 6.9696 10.1216 4.7158 4.0311
REC-1 CTRP2 7.0634 10.6825 4.5099 4.728
HEL CTRP2 7.1563 11.4081 4.2232 5.7539
SU-DHL-4 CTRP2 7.3876 15.7847 2.2433 13.2146
JVM-3 CTRP2 7.4908 10.5353 4.8593 2.7845
EHEB CTRP2 7.557 10.6684 4.8383 2.7865
NB4 CTRP2 7.5674 14.2306 3.1407 9.4746
KMM-1 CTRP2 7.7854 10.1043 5.2161 1.2355
Reh CTRP2 7.8132 9.1167 5.6183 0.1955
Raji CTRP2 7.8809 9.1454 5.6338 0.1545
KHM-1B CTRP2 8.2768 9.7331 5.5737 0.1495
P3HR-1 CTRP2 8.969 19.9336 1.3604 13.8079
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 4.6093 6.5145 4.3287 10.5706
TE15 CTRP2 4.6888 7.5419 3.9966 11.6404
OE21 CTRP2 2.4667 3.8706 2.462 23.8509
KYSE-30 CTRP2 2.8036 4.2035 2.7958 21.6168
TE-11 CTRP2 3.3758 5.0796 3.3277 17.9414
TE-5 CTRP2 3.7218 5.6191 3.6118 15.8515
KYSE-510 CTRP2 4.1684 5.7219 4.0753 12.8184
TE-14 CTRP2 4.3912 6.7783 3.9976 12.4429
KYSE-410 CTRP2 5.0668 7.7791 4.2706 9.5855
TE-4 CTRP2 5.3049 6.7158 4.9903 6.1015
KYSE-180 CTRP2 5.5788 6.5325 5.3526 3.9525
KYSE-150 CTRP2 5.9624 8.838 4.5787 6.3211
KYSE-140 CTRP2 5.9798 8.3063 4.8592 5.1081
TE-10 CTRP2 6.1211 9.0363 4.6118 5.8751
EC-GI-10 CTRP2 6.14 10.4446 3.9234 8.7265
COLO 680N CTRP2 6.1659 8.4082 4.9622 4.3199
OE33 CTRP2 6.1829 10.5828 3.8895 8.787
KYSE-70 CTRP2 6.3883 8.0684 5.3027 2.5132
TE-1 CTRP2 6.9588 9.6718 4.9245 3.2075
TE-9 CTRP2 6.9652 9.4612 5.029 2.7838
KYSE-520 CTRP2 7.5182 11.2511 4.5429 3.9682
OE19 CTRP2 7.6208 9.4017 5.4266 0.7216
KYSE-450 CTRP2 7.7636 9.3466 5.5126 0.4223
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.3985 10.2207 4.9478 2.558
MIA PaCa-2 CTRP2 2.6102 3.2994 2.6102 22.879
Panc 03.27 CTRP2 2.7281 4.0114 2.7241 22.107
Capan-1 CTRP2 2.9726 6.671 2.5021 22.1319
DAN-G CTRP2 3.2795 5.7075 3.1118 18.9999
Hs 766T CTRP2 3.5094 5.7744 3.3467 17.4516
Panc 08.13 CTRP2 3.6301 5.907 3.4458 16.7254
Panc 10.05 CTRP2 3.6677 6.2209 3.4004 16.775
SW1990 CTRP2 4.0519 6.3647 3.7747 14.2582
PaTu 8988s CTRP2 4.0668 6.3066 3.8092 14.0871
HuP-T4 CTRP2 4.2184 5.934 4.0807 12.6439
Panc 04.03 CTRP2 4.2232 6.1598 4.0242 12.8335
PSN1 CTRP2 4.3133 5.8601 4.2022 11.9174
SU.86.86 CTRP2 4.711 5.855 4.6362 9.1416
Capan-2 CTRP2 4.7147 7.3251 4.1176 11.095
HuP-T3 CTRP2 4.8414 8.1682 3.8667 11.7738
BxPC-3 CTRP2 5.1141 6.7457 4.7784 7.4412
AsPC-1 CTRP2 5.194 8.9637 3.827 11.1001
KP-2 CTRP2 5.4452 6.6255 5.1744 5.0063
PaTu 8902 CTRP2 5.5778 6.8149 5.2244 4.4677
KP-3 CTRP2 5.6364 7.9327 4.7419 6.3167
KP-4 CTRP2 5.7004 6.3092 5.574 2.7604
SNU-213 CTRP2 5.9107 8.3909 4.7579 5.6713
HPAC CTRP2 6.1144 8.3162 4.9663 4.3982
PK-45H CTRP2 6.2729 10.6006 3.9538 8.3505
SNU-410 CTRP2 6.2808 9.86 4.3298 6.7626
TCC-Pan2 CTRP2 6.3254 8.589 4.998 3.8849
YAPC CTRP2 6.4498 7.6205 5.5632 1.3607
L3.3 CTRP2 6.4875 7.6882 5.5559 1.3389
SUIT-2 CTRP2 6.503 8.3996 5.2237 2.6589
Panc 02.03 CTRP2 6.6905 11.4059 3.8812 7.9095
PK-59 CTRP2 6.7889 9.0939 5.0866 2.7955
Panc 05.04 CTRP2 6.8117 8.6824 5.2969 1.933
QGP-1 CTRP2 6.8447 9.6311 4.8662 3.6041
CFPAC-1 CTRP2 7.9097 9.6637 5.4534 0.4907
PaTu 8988t CTRP2 8.1117 9.7059 5.5208 0.272
HPAF-II CTRP2 8.4856 10.3767 5.4229 0.3267
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 1.7184 2.9143 1.718 28.8215
IGR-1 CTRP2 1.239 5.0235 1.0394 32.6677
Hs 839.T CTRP2 2.0138 6.1098 1.6277 28.1706
Hs 940.T CTRP2 2.0482 3.3664 2.0467 26.6283
Hs 934.T CTRP2 2.3482 3.0344 2.3482 24.6245
SK-MEL-24 CTRP2 2.421 2.9942 2.421 24.1396
Hs 688(A).T CTRP2 2.5349 3.546 2.5344 23.3824
WM115 CTRP2 2.5524 3.1496 2.5524 23.2643
COLO 792 CTRP2 2.5794 7.8275 1.6611 26.3093
Hs 895.T CTRP2 2.6139 4.2931 2.5969 22.9111
SK-MEL-3 CTRP2 2.6266 3.1927 2.6266 22.7698
UACC-257 CTRP2 2.6439 3.1739 2.6439 22.6546
A101D CTRP2 2.663 4.271 2.6488 22.5748
RVH-421 CTRP2 2.6647 4.1214 2.6566 22.5432
HT-144 CTRP2 2.6844 3.8269 2.6828 22.3899
Hs 294T CTRP2 2.7024 3.2078 2.7024 22.2648
IGR-37 CTRP2 2.7224 3.1894 2.7224 22.1319
WM266-4 CTRP2 2.7493 3.9378 2.7468 21.9607
UACC-62 CTRP2 2.7547 3.2072 2.7547 21.9166
CJM [Human melanoma] CTRP2 3.5287 5.3088 3.4591 16.9967
COLO 829 CTRP2 3.6364 6.2224 3.3657 16.9957
WM88 CTRP2 3.6398 5.0698 3.6082 16.1265
SK-MEL-2 CTRP2 3.6789 6.3051 3.3872 16.7899
WM983B CTRP2 3.9878 5.9582 3.8229 14.2762
MeWo CTRP2 4.0334 5.8969 3.8882 13.902
Mel Ho CTRP2 4.0371 5.0788 4.0236 13.418
WT2-iPS CTRP2 4.0843 6.0075 3.9152 13.6488
LOX-IMVI CTRP2 4.3039 6.4109 4.0336 12.5591
RPMI-7951 CTRP2 4.4932 5.8562 4.3989 10.6602
SK-MEL-5 CTRP2 4.642 5.7953 4.574 9.5766
SK-MEL-30 CTRP2 5.0634 5.9006 5.0094 6.7218
Mel JuSo CTRP2 5.1177 6.2336 4.9757 6.6794
IPC-298 CTRP2 5.2651 5.9745 5.212 5.376
WM793 CTRP2 5.6333 6.4142 5.4599 3.3863
SK-MEL-31 CTRP2 5.6617 6.3739 5.5065 3.1276
K029AX CTRP2 5.7429 6.5902 5.4923 2.9766
SK-MEL-28 CTRP2 5.8106 6.243 5.717 1.9061
COLO 800 CTRP2 5.9093 7.2612 5.3201 3.3158
G-361 CTRP2 5.9148 6.9063 5.5012 2.5463
Hs 936.T CTRP2 5.9751 6.5888 5.7125 1.5346
MDA-MB-435S CTRP2 6.004 6.9502 5.5574 2.1264
SK-MEL-1 CTRP2 6.0321 6.7938 5.6594 1.6423
WM1799 CTRP2 6.0646 6.8231 5.6717 1.5279
Hs 944.T CTRP2 6.159 8.0461 5.1374 3.5969
A2058 CTRP2 7.5938 8.4307 5.7771 0.0431
HMCB CTRP2 7.7289 8.9031 5.6627 0.1491
IGR-39 CTRP2 7.799 9.2143 5.5771 0.2727
Hs 852.T CTRP2 7.969 9.8716 5.3985 0.5934
A-375 CTRP2 8.3157 9.7734 5.5738 0.1418
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 4.6625 6.8602 4.2554 10.6996
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 CTRP2 2.1788 3.2327 2.1785 25.7541
IMR-32 CTRP2 2.2452 3.0703 2.2452 25.311
SK-N-AS CTRP2 2.3434 3.0622 2.3433 24.6569
SK-N-SH CTRP2 2.5082 3.9953 2.5009 23.5831
NH-6 CTRP2 2.6093 4.1207 2.6001 22.9157
SK-N-FI CTRP2 2.6826 3.2901 2.6826 22.3968
SK-N-DZ CTRP2 2.7291 3.3759 2.7291 22.087
SK-N-BE(2) CTRP2 2.7762 4.325 2.7626 21.8188
Kelly CTRP2 4.1843 5.4151 4.1452 12.5248
KP-N-YN CTRP2 4.8508 8.0848 3.9148 11.5567
CHP-126 CTRP2 5.0182 6.6863 4.7016 8.0004
NB1 CTRP2 5.5758 6.9982 5.1369 4.8271
KP-N-SI9s CTRP2 5.6303 8.8881 4.2642 8.322
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 3.5226 5.1474 3.4753 16.9604
HuH-28 CTRP2 5.2416 6.4322 5.0385 6.0878
SNU-478 CTRP2 5.2886 6.4645 5.0762 5.8122
SNU-308 CTRP2 5.8679 7.0551 5.3853 3.131
SNU-1196 CTRP2 6.5719 9.1687 4.8971 3.8951
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 1.8049 2.237 1.8049 28.244
A-673 CTRP2 2.4954 3.245 2.4953 23.6442
MG-63 CTRP2 2.5398 4.8374 2.469 23.5877
Hs 888.T CTRP2 2.5421 3.6333 2.5412 23.3358
SK-ES-1 CTRP2 2.5903 3.2886 2.5903 23.0114
Hs 822.T CTRP2 2.6083 3.2644 2.6083 22.8915
TC71 CTRP2 2.7353 3.2123 2.7353 22.0455
G-292 clone A141B1 CTRP2 3.3645 6.3181 3.0407 18.9962
SaOS-2 CTRP2 4.0471 5.7591 3.9354 13.6917
HOS CTRP2 4.0975 6.6554 3.7263 14.3052
MHH-ES-1 CTRP2 4.1488 5.5232 4.0912 12.8251
CAL-78 CTRP2 5.386 6.6485 5.1032 5.4431
SJSA-1 CTRP2 5.3872 6.7754 5.0494 5.6523
SW1353 CTRP2 7.2457 11.3318 4.3225 5.2195
U2OS CTRP2 8.4895 11.5655 4.957 1.499
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 70 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 1.67 2.3395 1.67 29.1426
MDA-MB-468 CTRP2 1.8343 3.522 1.8279 28.0695
BT-474 CTRP2 1.9463 4.5578 1.873 27.549
Hs 578T CTRP2 2.1574 4.5138 2.1016 26.0838
Hs 578Bst CTRP2 2.5108 3.8882 2.5064 23.5559
MDA-MB-453 CTRP2 2.7363 4.5789 2.7044 22.1464
AU565 CTRP2 3.0169 5.3725 2.8966 20.5818
HCC1500 CTRP2 3.0333 5.7 2.8455 20.7098
CAL-85-1 CTRP2 3.89 5.8418 3.7453 14.8547
T-47D CTRP2 4.305 6.8338 3.8844 13.1164
HCC1428 CTRP2 4.3132 6.805 3.904 13.0189
SK-BR-3 CTRP2 4.3643 7.7669 3.5647 14.1949
ZR-75-30 CTRP2 4.3878 7.2127 3.8233 13.1214
HCC1419 CTRP2 4.417 9.5211 2.8155 17.03
HMC-1-8 CTRP2 4.4464 5.2807 4.4352 10.6836
MDA-MB-415 CTRP2 4.7686 7.1854 4.2332 10.498
CAL-51 CTRP2 4.9434 6.8292 4.5648 8.734
BT-20 CTRP2 5.1039 6.9026 4.7019 7.7677
HCC2218 CTRP2 5.1386 12.0635 2.2502 17.5495
CAL-148 CTRP2 5.1688 7.4259 4.5353 8.2641
HCC1143 CTRP2 5.3211 8.0706 4.3796 8.5315
MDA-MB-157 CTRP2 5.3639 6.7948 5.017 5.841
HCC1395 CTRP2 5.5228 7.8076 4.6976 6.7553
HCC38 CTRP2 5.6903 8.8077 4.3576 7.8041
EFM-192A CTRP2 5.7056 13.1894 2.1858 16.5814
MDA-MB-231 CTRP2 5.7522 7.8068 4.9092 5.3671
JIMT-1 CTRP2 5.9731 6.8029 5.6042 1.9924
HCC1937 CTRP2 6.0602 8.0434 5.0581 4.1153
KPL-1 CTRP2 6.0624 6.9236 5.6197 1.7507
ZR-75-1 CTRP2 6.4548 8.8401 4.9721 3.7744
MDA-MB-361 CTRP2 7.0993 11.0197 4.3716 5.2361
HCC202 CTRP2 7.1247 12.4379 3.6972 7.9458
BT-549 CTRP2 7.1457 13.6754 3.1033 10.3054
MCF-7 CTRP2 8.0044 10.2496 5.2637 0.933
CAMA-1 CTRP2 8.2365 14.2561 3.5903 6.7382
HCC1806 CTRP2 8.513 9.8343 5.6226 0.0655
HCC1954 CTRP2 8.7388 10.522 5.4673 0.1921
BT 416 CTRP2 2.1282 3.8855 2.1163 26.1299
BT 231 CTRP2 2.3668 3.8456 2.3611 24.5199
BT 228 CTRP2 2.529 2.941 2.529 23.4202
BT 239 CTRP2 2.5572 3.3971 2.5572 23.2321
BT 286 CTRP2 2.6308 4.8185 2.5682 22.9538
BT 139 CTRP2 2.6542 3.2529 2.6542 22.586
BT147 CTRP2 2.6879 4.5294 2.6579 22.4624
BT 504 CTRP2 2.6917 3.1737 2.6917 22.3364
BT 245 CTRP2 2.6954 4.9791 2.6157 22.5822
BT 159 CTRP2 2.7459 4.0178 2.742 21.9882
BT 172 CTRP2 2.7466 4.5125 2.7205 22.058
BT 482 CTRP2 2.7603 4.1072 2.7545 21.8983
BT 271 CTRP2 3.3939 6.1113 3.1332 18.5717
BT 131 CTRP2 3.3941 6.0675 3.1457 18.5257
BT 216 CTRP2 3.4112 5.6086 3.2769 18.005
BT 248 CTRP2 3.7553 5.3309 3.6986 15.4428
BT 359 CTRP2 3.972 6.3794 3.6831 14.8321
BT 422 CTRP2 3.9917 6.9658 3.4991 15.4642
BT 340 CTRP2 4.0522 6.1149 3.8506 13.9796
BT 330 CTRP2 4.0838 6.7269 3.686 14.4956
BT 444 CTRP2 4.1255 6.3448 3.8611 13.7222
BT 145 CTRP2 4.2882 6.9528 3.821 13.4051
BT 232 CTRP2 4.4521 7.5996 3.7277 13.3222
BT 498 CTRP2 4.6329 6.8408 4.2316 10.8728
BT 440 CTRP2 4.716 11.4283 2.1786 18.7796
BT 333 CTRP2 4.8155 8.8008 3.5441 13.1436
BT 320 CTRP2 5.0834 7.9882 4.1892 9.8754
BT 187 CTRP2 5.2244 6.8944 4.8301 6.9446
BT 328 CTRP2 6.0063 10.8055 3.632 10.1985
BT 179 CTRP2 6.058 9.0093 4.5733 6.157
BT 112 CTRP2 6.3421 10.6055 4.0069 8.0018
BT164 CTRP2 8.0155 13.6252 3.7441 6.4388
BT 224 CTRP2 8.4367 12.6413 4.4618 3.2099
⏷ Show the Full List of 70 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 5.7514 7.5748 5.0232 4.8935
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
42-MG-BA CTRP2 1.4163 6.6256 0.8237 32.7335
A-172 CTRP2 2.0971 6.7496 1.5252 28.2551
KG-1-C CTRP2 2.4677 3.3657 2.4675 23.8292
Hs 683 CTRP2 2.4821 3.323 2.4821 23.7324
SF539 CTRP2 2.4975 4.0973 2.4864 23.6672
KNS-42 CTRP2 2.605 4.3546 2.584 22.9841
SF268 CTRP2 2.7035 4.0981 2.697 22.2791
D283 Med CTRP2 2.7602 3.3805 2.7602 21.8798
U-118MG CTRP2 2.8867 5.6471 2.6981 21.6883
T98G CTRP2 3.0242 6.4132 2.6407 21.4731
YH-13 CTRP2 3.1822 9.7344 1.4864 25.1748
M059K CTRP2 3.5755 9.6335 1.9293 22.5452
YKG-1 CTRP2 3.7294 5.1435 3.6951 15.5387
U-251MG CTRP2 3.9234 5.692 3.8156 14.5015
DK-MG CTRP2 4.2849 8.8375 3.004 16.6149
LN-18 CTRP2 4.3252 4.9208 4.3242 11.457
KNS-60 CTRP2 4.4182 5.2109 4.4103 10.8604
GOS-3 CTRP2 4.5163 10.812 2.292 18.8209
SNB-75 CTRP2 4.5595 7.2361 3.9938 11.9936
LN-229 CTRP2 4.7093 6.6184 4.3984 10.0224
SW1088 CTRP2 5.1658 6.7321 4.8383 7.0683
GaMG CTRP2 5.1874 6.3369 5.0156 6.3283
Becker CTRP2 5.1876 8.0234 4.274 9.2787
SW1783 CTRP2 5.2641 8.7395 4.0018 10.2192
KNS-81 CTRP2 5.3651 6.1523 5.271 4.8596
SF295 CTRP2 5.4896 7.2951 4.9126 5.949
SNU-489 CTRP2 5.5267 6.0569 5.476 3.6269
ONS-76 CTRP2 5.5512 6.3504 5.4 3.8414
Daoy CTRP2 5.5923 7.0277 5.1391 4.7784
KALS-1 CTRP2 5.6525 15.5876 0.9424 21.049
NMC-G1 CTRP2 5.7613 7.3399 5.1479 4.3528
GB-1 CTRP2 5.8228 6.6425 5.5453 2.5689
SF126 CTRP2 5.8408 6.8502 5.4614 2.874
SNU-466 CTRP2 5.9944 7.1678 5.4405 2.6367
CCF-STTG1 CTRP2 6.7224 13.3284 2.9508 11.644
SNU-1105 CTRP2 7.5884 9.0022 5.5698 0.3724
SNU-201 CTRP2 7.6776 10.3618 5.0469 1.8981
DBTRG-05MG CTRP2 7.697 11.2348 4.663 3.2847
U-87MG ATCC CTRP2 7.8492 9.3731 5.5384 0.3303
TM-31 CTRP2 8.0845 11.8521 4.613 3.0342
GMS-10 CTRP2 8.1012 9.2225 5.6861 0.0599
8-MG-BA CTRP2 8.4131 10.5488 5.3291 0.5428
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN CTRP2 2.5417 5.5855 2.3367 24.0412
JHUEM-1 CTRP2 2.621 3.1062 2.621 22.8072
ESS-1 CTRP2 3.7395 5.0701 3.7132 15.4442
MFE-296 CTRP2 3.9612 6.172 3.7348 14.6749
HEC-1-A CTRP2 4.0226 5.7266 3.9159 13.837
MFE-319 CTRP2 4.0925 5.8683 3.9596 13.4644
JHUEM-3 CTRP2 4.1526 6.8281 3.7231 14.1597
AN3-CA CTRP2 5.0127 8.5718 3.8438 11.4528
JHUEM-2 CTRP2 5.1304 7.4286 4.4956 8.5199
KLE CTRP2 5.6248 7.6402 4.8745 5.7921
HEC-151 CTRP2 5.7268 6.5109 5.5128 2.934
EFE-184 CTRP2 5.7325 6.6741 5.4428 3.2029
HEC-6 CTRP2 6.4497 8.2994 5.2343 2.6982
RL95-2 CTRP2 6.525 9.058 4.9169 3.8883
JHUEM-7 CTRP2 7.0547 10.478 4.6027 4.365
HEC-59 CTRP2 7.0681 9.2864 5.1763 2.0821
HEC-108 CTRP2 7.2388 8.9787 5.4124 1.0545
HEC-50B CTRP2 7.4665 11.4801 4.4008 4.5962
HEC-265 CTRP2 7.5359 8.8693 5.5983 0.3321
HEC-251 CTRP2 7.5862 8.9554 5.5868 0.3357
HEC-1-B CTRP2 8.7155 10.9835 5.2908 0.4986
Ishikawa (Heraklio) 02 ER- CTRP2 7.4475 8.2807 5.7769 0.0617
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-3 CTRP2 1.9201 3.2921 1.9184 27.4821
KMRC-1 CTRP2 2.4285 3.4442 2.4281 24.0909
CAL-54 CTRP2 2.4296 3.3818 2.4294 24.0827
KMRC-2 CTRP2 2.5623 4.0571 2.5542 23.2252
UO-31 CTRP2 2.5861 3.6687 2.5852 23.0426
RCC10RGB CTRP2 2.594 3.9392 2.5897 23.0014
786-O CTRP2 3.5172 5.6219 3.3892 17.277
VMRC-RCZ CTRP2 4.2119 5.9535 4.0687 12.7069
TUHR14TKB CTRP2 4.6921 8.6801 3.4805 13.7001
Caki-1 CTRP2 4.8858 7.2188 4.3402 9.767
VMRC-RCW CTRP2 5.0552 6.3981 4.8512 7.3261
TUHR10TKB CTRP2 5.0632 5.8865 5.0122 6.7122
BFTC-909 CTRP2 5.3199 6.2608 5.1856 5.3089
KMRC-20 CTRP2 5.3849 6.9717 4.9594 6.0167
SNU-1272 CTRP2 6.6415 7.9277 5.5416 1.2007
ACHN CTRP2 7.5373 11.4653 4.4543 4.2905
A-498 CTRP2 7.5736 9.7542 5.2555 1.2831
Caki-2 CTRP2 8.0811 9.5386 5.5694 0.2005
OS-RC-2 CTRP2 8.0977 10.1958 5.3285 0.7008
769-P CTRP2 8.6802 10.3788 5.4959 0.1675
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 15 CTRP2 2.684 3.9678 2.6803 22.4
HCC-56 CTRP2 2.8262 4.4672 2.8063 21.5068
NCI-H747 CTRP2 2.8394 4.9698 2.7707 21.5851
NCI-H716 CTRP2 2.9293 5.0737 2.8522 21.015
T84 CTRP2 3.3837 5.0068 3.3445 17.8581
C2BBe1 CTRP2 3.5028 5.4054 3.4153 17.2312
LS1034 CTRP2 3.5195 5.1747 3.4685 16.9943
HT115 CTRP2 3.5383 4.3743 3.5372 16.6997
SNU-C1 CTRP2 3.5963 5.2138 3.5452 16.483
SW48 CTRP2 3.6046 5.2721 3.546 16.4532
KM12 CTRP2 3.7318 7.7211 2.925 18.3794
SW948 CTRP2 3.9658 5.9372 3.8043 14.4103
HCT 8 CTRP2 3.9703 5.9907 3.7953 14.4286
SW1417 CTRP2 4.0796 7.4269 3.4113 15.5562
SNU-503 CTRP2 4.517 6.4846 4.2394 11.1717
CCK-81 CTRP2 4.5266 7.4864 3.8535 12.6307
RKO CTRP2 4.7897 7.0651 4.3059 10.1569
COLO 320 CTRP2 4.8362 6.9721 4.3933 9.691
SNU-407 CTRP2 4.9118 6.2996 4.7303 8.1932
OUMS-23 CTRP2 4.9371 6.1832 4.7954 7.8785
CL-11 CTRP2 4.9566 6.9418 4.532 8.8263
COLO 678 CTRP2 4.9633 9.7204 3.2427 14.0208
LS513 CTRP2 5.2207 6.174 5.107 5.8912
SNU-175 CTRP2 5.3299 7.9728 4.4351 8.2825
SNU-61 CTRP2 5.4511 6.8334 5.0887 5.3311
SK-CO-1 CTRP2 5.4566 7.0243 5.0072 5.6448
NCI-H508 CTRP2 5.5098 6.2671 5.3879 4.0034
LS180 CTRP2 5.533 6.6677 5.2461 4.4938
DLD-1 CTRP2 5.7558 6.2236 5.6672 2.2481
HT-55 CTRP2 5.9796 7.1931 5.4152 2.7727
SNU-C5 CTRP2 6.048 7.4054 5.3669 2.8409
LoVo CTRP2 6.0732 7.8736 5.1537 3.6887
HT-29 CTRP2 6.1394 7.9303 5.1794 3.4565
LS411N CTRP2 6.2477 7.395 5.5302 1.7993
LS123 CTRP2 6.2734 7.529 5.4832 1.952
RCM-1 [Human ESC] CTRP2 6.3659 9.48 4.5866 5.5343
MDST8 CTRP2 6.5504 7.8601 5.5157 1.4146
SW620 CTRP2 6.6464 8.4265 5.31 2.1003
SNU-C4 CTRP2 6.9308 10.0272 4.7346 4.0116
COLO205 CTRP2 7.1054 9.8948 4.9154 3.0459
COLO201 CTRP2 7.8672 11.3112 4.7303 2.8399
HCT 116 CTRP2 8.284 9.7186 5.5813 0.1386
GP2d CTRP2 8.7631 10.6227 5.4409 0.2225
CW-2 CTRP2 8.8012 10.5227 5.4898 0.1524
SNU-C2A CTRP2 9.3894 11.5524 5.3457 0.2157
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 CTRP2 2.5606 3.1953 2.5606 23.2098
HLF CTRP2 2.632 5.4623 2.4616 23.3194
SNU-423 CTRP2 2.7002 3.875 2.6981 22.2865
JHH-5 CTRP2 3.5614 4.9969 3.5329 16.6381
SNU-449 CTRP2 3.6992 5.2753 3.6466 15.8024
HuH-6 CTRP2 3.8398 5.7978 3.701 15.1676
JHH-6 CTRP2 3.8686 5.8097 3.7296 14.9769
PLC/PRF/5 CTRP2 3.9769 5.6338 3.8855 14.0878
SNU-387 CTRP2 4.063 7.0181 3.5555 15.0488
SNU-182 CTRP2 4.2178 5.4987 4.1691 12.3343
SK-HEP-1 CTRP2 4.2378 6.4836 3.9376 13.109
JHH-2 CTRP2 4.319 6.704 3.9476 12.8372
JHH-4 CTRP2 4.5441 8.498 3.4188 14.3135
Li-7 CTRP2 5.0258 6.3526 4.8355 7.4696
Hep-G2 CTRP2 5.9045 8.8059 4.5454 6.5761
SNU-886 CTRP2 5.957 7.0907 5.4468 2.686
SNU-475 CTRP2 6.6016 9.7659 4.6251 4.9727
HuH-1 CTRP2 7.75 12.3487 4.1752 5.1056
Hep 3B2.1-7 CTRP2 7.7624 12.8767 3.9322 6.047
SNU-398 CTRP2 8.5132 10.3863 5.4303 0.3054
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 139 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 CTRP2 -0.994 6.1603 -1.6688 47.4564
NCI-H2141 CTRP2 1.0124 8.1259 -0.129 36.6921
COR-L279 CTRP2 1.6983 3.5184 1.6897 28.983
NCI-H2081 CTRP2 1.7791 6.1929 1.3482 29.8649
DV-90 CTRP2 2.0837 3.913 2.0695 26.4343
COR-L51 CTRP2 2.1705 4.0217 2.1537 25.8645
COR-L88 CTRP2 2.2417 12.3877 -0.6678 33.9249
NCI-H1693 CTRP2 2.2655 4.7355 2.1901 25.4307
NCI-H146 CTRP2 2.3487 3.2332 2.3486 24.6215
SK-MES-1 CTRP2 2.3642 3.9389 2.3558 24.546
NCI-H810 CTRP2 2.5128 3.5717 2.5122 23.53
NCI-H1341 CTRP2 2.6292 3.9526 2.6251 22.7663
DMS 53 CTRP2 2.6367 4.0813 2.6293 22.7273
NCI-H1944 CTRP2 2.6431 4.2175 2.6308 22.701
NCI-H1105 CTRP2 2.6436 4.4729 2.616 22.7492
DMS 454 CTRP2 2.6468 4.0141 2.6415 22.6529
NCI-H1694 CTRP2 2.6859 3.3749 2.6859 22.3745
HOP-62 CTRP2 2.7167 3.8589 2.7149 22.1756
LK2 CTRP2 2.7518 3.1971 2.7518 21.9356
Lu-65 CTRP2 2.8211 7.1956 2.1566 23.8361
NCI-H23 CTRP2 3.2178 7.0506 2.6363 20.918
COR-L95 CTRP2 3.2657 5.422 3.1563 18.8865
NCI-H522 CTRP2 3.2894 4.9918 3.2464 18.4994
COLO 668 CTRP2 3.396 5.9881 3.1693 18.4351
NCI-H647 CTRP2 3.4226 5.2567 3.3533 17.7025
NCI-H1915 CTRP2 3.4472 5.1278 3.3976 17.4709
DMS 114 CTRP2 3.5613 5.0517 3.5272 16.6578
NCI-H841 CTRP2 3.6101 6.4614 3.2632 17.4496
RERF-LC-MS CTRP2 3.6435 6.3315 3.3406 17.066
NCI-H1568 CTRP2 3.6724 5.882 3.4982 16.4079
NCI-H2087 CTRP2 3.7432 6.0761 3.5243 16.0977
NCI-H2196 CTRP2 3.8231 6.9348 3.3298 16.5833
HOP-92 CTRP2 3.8311 5.8619 3.6762 15.2828
LUDLU-1 CTRP2 3.8935 5.8205 3.7541 14.8124
NCI-H1666 CTRP2 3.894 6.7064 3.4885 15.7832
SW1271 CTRP2 3.9049 5.4858 3.8349 14.4925
DMS 273 CTRP2 3.9087 6.2868 3.6432 15.1666
NCI-H2029 CTRP2 3.9394 5.96 3.7696 14.6156
NCI-H1563 CTRP2 3.9558 6.0961 3.7508 14.6333
HCC4006 CTRP2 4.0326 6.2602 3.7863 14.2728
NCI-H1092 CTRP2 4.0632 6.8425 3.6217 14.7969
NCI-H1339 CTRP2 4.0973 6.3138 3.8402 13.8828
T3M-10 CTRP2 4.1308 6.8491 3.6919 14.3397
NCI-H211 CTRP2 4.1656 6.1587 3.9617 13.2342
NCI-H2170 CTRP2 4.1989 5.861 4.0773 12.7165
HCC1438 CTRP2 4.2262 5.477 4.1813 12.2655
EBC-1 CTRP2 4.2707 5.4028 4.2387 11.9248
NCI-H520 CTRP2 4.2775 6.638 3.9267 13.0351
NCI-H2110 CTRP2 4.2792 6.2351 4.0627 12.5251
LCLC-97TM1 CTRP2 4.3403 6.9792 3.8662 13.0868
HCC2935 CTRP2 4.3769 6.502 4.0819 12.1663
NCI-H69 CTRP2 4.5255 6.4668 4.2549 11.0893
SK-LU-1 CTRP2 4.5293 6.0458 4.3905 10.5795
NCI-H1793 CTRP2 4.5336 6.3871 4.2908 10.9321
ChaGo-K-1 CTRP2 4.6273 6.8998 4.2023 11.0008
NCI-H322 CTRP2 4.6708 6.4293 4.4251 10.0321
NCI-H1734 CTRP2 4.7396 6.8569 4.3384 10.1673
VMRC-LCD CTRP2 4.7734 7.841 3.9492 11.612
EKVX CTRP2 4.7858 8.3229 3.7398 12.4237
COR-L105 CTRP2 4.8643 8.4499 3.7575 12.1602
HCC15 CTRP2 4.973 6.5577 4.7036 8.1186
KNS-62 CTRP2 5.0444 6.5783 4.7719 7.6578
HCC95 CTRP2 5.0706 6.2736 4.9113 7.0567
NCI-H2122 CTRP2 5.0907 6.432 4.877 7.1276
A-549 CTRP2 5.1333 7.3799 4.5208 8.4114
HCC44 CTRP2 5.1666 6.3839 4.9762 6.5362
NCI-H446 CTRP2 5.2063 6.2926 5.0517 6.1386
NCI-H889 CTRP2 5.2326 8.7107 3.9863 10.3552
Calu-3 CTRP2 5.2593 7.1315 4.7604 7.1324
NCI-H1581 CTRP2 5.2805 6.9526 4.862 6.6725
HCC1588 CTRP2 5.3046 6.514 5.0735 5.7786
HCC2279 CTRP2 5.3197 6.8586 4.9437 6.2468
NCI-H2106 CTRP2 5.3255 6.8954 4.9334 6.2727
NCI-H1755 CTRP2 5.3319 6.6362 5.052 5.7879
NCI-H1573 CTRP2 5.3405 6.7679 5.0047 5.9512
NCI-H2228 CTRP2 5.3468 6.5662 5.0968 5.5731
NCI-H1838 CTRP2 5.4187 6.3641 5.2538 4.77
NCI-H1155 CTRP2 5.436 6.3307 5.2851 4.6022
NCI-H526 CTRP2 5.4364 6.2371 5.3198 4.4701
Sq-1 CTRP2 5.489 6.3801 5.3223 4.3121
Lu-99 CTRP2 5.505 6.3973 5.3323 4.2298
NCI-H292 CTRP2 5.5069 7.1186 5.0128 5.4987
LXF 289 CTRP2 5.5259 6.7811 5.1878 4.7447
NCI-H1355 CTRP2 5.5363 7.8848 4.6727 6.8274
PC-14 CTRP2 5.5521 6.6605 5.2688 4.3543
NCI-H1184 CTRP2 5.5792 8.424 4.4477 7.6669
Calu-1 CTRP2 5.6405 8.6675 4.3827 7.8051
EPLC-272H CTRP2 5.6925 6.8936 5.2999 3.8819
Calu-6 CTRP2 5.7062 6.8644 5.3271 3.7382
RERF-LC-A1 CTRP2 5.7178 7.2391 5.157 4.4124
SBC-5 CTRP2 5.7651 6.559 5.5288 2.774
LC-1/sq-SF CTRP2 5.8015 6.4157 5.6313 2.2703
NCI-H1792 CTRP2 5.8249 9.4306 4.1651 8.3321
NCI-H358 CTRP2 5.8259 7.4546 5.1498 4.2042
NCI-H1373 CTRP2 5.8994 8.6738 4.607 6.3277
HARA [Human squamous cell lung carcinoma] CTRP2 5.9336 6.935 5.5037 2.4962
NCI-H838 CTRP2 5.9466 9.7695 4.0998 8.3625
CAL-12T CTRP2 5.9575 7.4275 5.2791 3.3884
HCC1833 CTRP2 5.9766 8.9161 4.5517 6.4065
MOR/CPR CTRP2 5.9895 7.029 5.5056 2.3728
NCI-H1435 CTRP2 5.9998 7.027 5.5155 2.3106
HCC366 CTRP2 6.0412 7.3457 5.3911 2.7521
NCI-H650 CTRP2 6.0979 10.3232 3.9494 8.6982
NCI-H196 CTRP2 6.1006 7.9854 5.1203 3.7771
NCI-H1650 CTRP2 6.1382 7.3839 5.4511 2.3185
LOU-NH91 CTRP2 6.1858 8.3001 5.0321 3.99
NCI-H226 CTRP2 6.1901 7.4446 5.4617 2.182
NCI-H1395 CTRP2 6.2012 9.679 4.3561 6.7991
NCI-H2023 CTRP2 6.2385 7.4712 5.4856 1.9997
HCC1171 CTRP2 6.3223 8.9148 4.8337 4.5771
NCI-H2126 CTRP2 6.3661 7.5526 5.5387 1.5793
HCC1195 CTRP2 6.4559 8.1547 5.3094 2.3799
NCI-H2291 CTRP2 6.5313 11.4236 3.749 8.7346
NCI-H661 CTRP2 6.7942 11.0513 4.135 6.6858
NCI-H727 CTRP2 6.9436 9.62 4.9391 3.1701
NCI-H1299 CTRP2 6.9444 8.821 5.3152 1.7016
RERF-LC-Ad1 CTRP2 6.9567 8.9872 5.246 1.9498
HCC78 CTRP2 7.0605 9.657 4.9984 2.7787
SHP-77 CTRP2 7.0639 9.2797 5.1768 2.0848
NCI-H2085 CTRP2 7.0642 9.7287 4.0943 1.499
NCI-H2405 CTRP2 7.0961 11.9496 3.9158 7.0999
HCC2108 CTRP2 7.1059 10.4812 4.6362 4.1565
IA-LM CTRP2 7.2811 9.4458 5.2302 1.646
BEN CTRP2 7.2844 8.2848 5.7141 0.1928
HCC827 CTRP2 7.2846 10.6328 4.6832 3.7237
NCI-H1651 CTRP2 7.2934 27.484 -3.6532 28.7804
LCLC-103H CTRP2 7.3893 9.754 5.1543 1.8067
NCI-H2030 CTRP2 7.3925 9.6851 5.1869 1.6871
NCI-H1869 CTRP2 7.8352 12.1322 4.3321 4.3836
NCI-H2342 CTRP2 7.8579 14.4872 3.2222 8.7101
RERF-LC-Ad2 CTRP2 7.8786 13.9692 3.4868 7.641
NCI-H460 CTRP2 7.9596 9.1261 5.6693 0.0946
NCI-H441 CTRP2 8.0327 10.4121 5.2108 1.0672
NCI-H2286 CTRP2 8.1632 9.5685 5.5895 0.1524
NCI-H1623 CTRP2 8.1947 13.4735 3.9325 5.4708
NCI-H2172 CTRP2 8.3654 11.319 4.9981 1.4662
NCI-H2009 CTRP2 8.454 10.0843 5.5158 0.1885
COLO 699 CTRP2 8.5109 10.2049 5.4944 0.2054
Hs 888.Lu CTRP2 2.6102 4.034 2.6038 22.9007
⏷ Show the Full List of 139 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -0.4294 6.0548 -1.0235 44.147
COV434 CTRP2 2.0877 3.3873 2.0862 26.3652
COV644 CTRP2 2.1464 4.9002 2.0393 26.3323
OAW42 CTRP2 2.5299 3.1159 2.5299 23.4142
OC 314 CTRP2 2.6899 3.2055 2.6899 22.3482
OVCAR-5 CTRP2 3.4618 5.3089 3.3873 17.4595
COV362 CTRP2 3.8239 5.8567 3.6697 15.3282
OV7 CTRP2 3.9337 6.4978 3.6029 15.2416
TOV-112D CTRP2 4.001 5.376 3.9549 13.7697
TYK-nu CTRP2 4.0991 5.1016 4.0865 13.0022
A2780 CTRP2 4.3702 6.0488 4.2161 11.6928
EFO-21 CTRP2 4.6268 6.7195 4.272 10.7355
OVK18 CTRP2 4.7107 5.9331 4.6178 9.2077
EFO-27 CTRP2 4.7391 6.4302 4.4986 9.5596
SNU-119 CTRP2 4.9286 6.1885 4.7845 7.9434
JHOS-2 CTRP2 5.087 7.7149 4.3205 9.3338
SNU-8 CTRP2 5.1858 5.8156 5.1585 5.8132
MCAS CTRP2 5.2913 6.9713 4.8648 6.6336
IGROV-1 CTRP2 5.4993 7.3386 4.9013 5.9717
Caov-3 CTRP2 5.6164 7.7953 4.7909 6.1579
OVCAR-8 CTRP2 5.8065 7.8315 4.9456 5.0996
SNU-840 CTRP2 5.8101 7.7152 5.0065 4.8371
HEY A8 CTRP2 5.878 7.8542 4.9973 4.7335
OAW28 CTRP2 6.0337 9.2796 4.4178 6.8573
RMG-I CTRP2 6.1792 8.0508 5.1512 3.5019
Kuramochi CTRP2 6.3384 8.517 5.0438 3.6714
JHOC-5 CTRP2 6.4878 7.8397 5.484 1.6246
OV-90 CTRP2 6.6004 9.5478 4.7317 4.5331
ONCO-DG-1 CTRP2 6.6441 8.6179 5.2166 2.4781
TOV-21G CTRP2 6.7542 8.5526 5.321 1.9127
OV56 CTRP2 6.7746 10.358 4.4618 5.368
FU-OV-1 CTRP2 6.9351 14.038 2.7634 12.008
JHOM-1 CTRP2 7.1276 8.8569 5.4053 1.1805
SK-OV-3 CTRP2 7.2576 9.2219 5.3165 1.3642
OVCAR-4 CTRP2 7.4009 9.7177 5.1771 1.7133
DOV13 CTRP2 7.4877 8.9811 5.5338 0.5116
OVSAHO CTRP2 7.6636 9.7485 5.3042 1.0544
ES2 CTRP2 7.7747 8.9857 5.6506 0.1557
OVISE CTRP2 7.8414 8.9606 5.6839 0.0982
OVTOKO CTRP2 8.5988 11.0871 5.2016 0.752
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 2.2461 4.7725 2.1645 25.581
P-STS CTRP2 6.3559 10.0574 4.2913 6.7881
H-STS CTRP2 7.1002 7.9855 5.7507 0.1886
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 2.503 4.8529 2.4277 23.8486
Aska-SS CTRP2 2.7067 4.2186 2.696 22.2717
A-204 CTRP2 -0.8251 4.7887 -1.1508 46.1957
G-402 CTRP2 0.6497 5.1812 0.3683 36.7804
TE 441.T CTRP2 2.2141 3.8799 2.2045 25.5498
Tm87-16 CTRP2 2.3892 3.334 2.389 24.3523
Hs 729.T CTRP2 2.468 3.9329 2.4617 23.8475
TTC-709 CTRP2 2.503 4.0972 2.4921 23.6298
BT-12 CTRP2 2.5688 3.1362 2.5688 23.1549
TE 617.T CTRP2 2.5806 4.0615 2.5728 23.1024
GCT CTRP2 2.582 3.355 2.5819 23.0674
BT-16 CTRP2 2.626 3.3257 2.626 22.7737
G-401 CTRP2 2.6602 4.802 2.6014 22.7447
HT-1080 CTRP2 2.6768 3.8642 2.6747 22.4424
MES-SA CTRP2 2.7222 3.9528 2.7192 22.143
SW982 CTRP2 2.7257 4.2032 2.7161 22.1417
KYM-1 CTRP2 2.7387 3.9105 2.7365 22.0302
RD CTRP2 2.9424 6.4577 2.5378 22.0925
SK-LMS-1 CTRP2 3.5797 5.466 3.4876 16.7351
Rh41 CTRP2 3.8966 6.4518 3.5778 15.4432
Rh18 CTRP2 4.2604 6.0029 4.1086 12.4149
SK-UT-1 CTRP2 4.7426 10.0103 2.894 15.9367
RKN CTRP2 6.4922 7.8209 5.4959 1.5711
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.8075 11.2318 4.0559 6.9906
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 CTRP2 2.3668 4.1999 2.3467 24.5679
IST-Mes1 CTRP2 2.5987 4.3648 2.5769 23.0291
NCI-H2452 CTRP2 4.8639 6.9657 4.4251 9.4926
NCI-H28 CTRP2 5.0115 6.5583 4.7445 7.8544
MSTO-211H CTRP2 5.6491 8.2513 4.5963 6.8954
ACC-MESO-1 CTRP2 6.4302 8.8674 4.9401 3.9484
JL-1 CTRP2 7.679 12.5085 4.0522 5.6873
NCI-H2052 CTRP2 7.7779 9.7005 4.4188 0.2689
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 2.7003 3.9966 2.6962 22.2927
LNCaP clone FGC CTRP2 3.6337 5.795 3.4772 16.6025
NCI-H660 CTRP2 4.5577 6.6358 4.2292 11.0936
PaCa-3 CTRP2 5.2765 6.4907 5.053 5.9353
DU145 CTRP2 5.4109 8.1803 4.4115 8.193
22Rv1 CTRP2 8.8967 11.2525 5.2644 0.4827
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 3.845 5.6453 3.7401 15.0134
YD-15 CTRP2 5.5929 8.4638 4.4405 7.6668
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KATO III CTRP2 2.2054 4.0772 2.1867 25.6386
LMSU CTRP2 2.2642 6.6941 1.7249 27.0493
SNU-1 CTRP2 2.5276 4.3768 2.5022 23.5147
Hs 746.T CTRP2 2.5958 4.3143 2.577 23.0379
SNU-16 CTRP2 2.6306 4.011 2.6252 22.7613
HGC-27 CTRP2 2.6915 4.1774 2.6821 22.369
IM95 CTRP2 2.7618 5.8161 2.5216 22.7017
HuG1-N CTRP2 3.6477 5.5971 3.536 16.3508
SNU-601 CTRP2 3.6745 5.3855 3.6036 16.0299
GSS CTRP2 3.7185 4.7357 3.7125 15.5156
SNU-216 CTRP2 3.8641 5.8561 3.7136 15.0476
SNU-620 CTRP2 4.2734 6.4222 3.9967 12.7853
SNU-5 CTRP2 4.5196 6.137 4.3541 10.7408
KE-39 CTRP2 4.6449 7.4749 3.9807 11.8179
ECC10 CTRP2 4.756 5.9176 4.6708 8.8789
SH-10-TC CTRP2 4.9865 7.1419 4.4774 8.9613
GSU CTRP2 4.9974 5.5159 4.9918 6.994
NCI-N87 CTRP2 5.1656 6.9298 4.7541 7.399
23132/87 CTRP2 5.4166 6.2113 5.3074 4.5735
NUGC-4 CTRP2 5.6084 6.7556 5.2823 4.1578
MKN1 CTRP2 5.918 6.7136 5.5994 2.1298
MKN74 CTRP2 5.9432 9.1936 4.3847 7.1739
SNU-719 CTRP2 6.0019 8.7672 4.6475 5.9542
NUGC-3 CTRP2 6.2332 7.4538 5.4902 1.9896
ECC12 CTRP2 6.6293 8.1645 5.4232 1.6745
MKN45 CTRP2 6.6953 12.5981 3.2929 10.316
MKN7 CTRP2 6.7515 11.6466 3.8085 8.1059
SNU-668 CTRP2 6.9547 10.0245 4.7524 3.9047
AGS CTRP2 7.1447 9.584 5.0859 2.3344
Fu97 CTRP2 7.6074 9.606 5.3358 0.9997
SNG-M CTRP2 5.3784 6.6132 5.1103 5.4357
SNU-685 CTRP2 6.4195 10.5022 4.1199 7.3907
SNU-1077 CTRP2 7.4979 10.2086 5.0127 2.2057
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 -0.7087 4.4144 -0.9529 45.3812
CGTH-W-1 CTRP2 2.1942 9.8418 0.4267 31.357
BHT-101 CTRP2 3.8578 4.6805 3.8556 14.5749
TT2609-C02 CTRP2 4.692 6.6401 4.3718 10.1724
8305C CTRP2 4.7459 5.8175 4.6822 8.8701
TT CTRP2 4.8873 6.4789 4.641 8.5986
8505C CTRP2 4.9675 6.1665 4.8337 7.6475
B-CPAP CTRP2 5.1764 6.0122 5.1057 6.0292
ML-1 [Human leukemia] CTRP2 5.5749 6.4366 5.3895 3.8177
CAL-62 CTRP2 5.6148 7.1211 5.1164 4.8176
FTC-133 CTRP2 7.6339 10.2521 5.071 1.8564
FTC-238 CTRP2 8.0896 11.2404 4.8878 2.0565
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 18 CTRP2 2.0031 5.2867 1.8154 27.562
BICR 22 CTRP2 2.6664 4.3449 2.6483 22.5656
PE/CA-PJ49 CTRP2 2.7022 4.1575 2.6938 22.2942
CAL-27 CTRP2 2.7507 4.4918 2.7263 22.0248
SCC-9 CTRP2 3.2411 5.6408 3.0851 19.2138
CAL-33 CTRP2 3.7304 5.8165 3.5775 15.9461
SCC-25 CTRP2 4.1631 5.7656 4.0601 12.8886
PE/CA-PJ15 CTRP2 4.2949 6.2948 4.0613 12.4833
HSC-2 CTRP2 4.4163 6.2008 4.2226 11.5302
FaDu CTRP2 4.446 6.0493 4.2987 11.1642
BICR 31 CTRP2 4.4984 7.6853 3.7384 13.1583
PE/CA-PJ34 (clone C12) CTRP2 4.5796 7.6297 3.8461 12.5204
YD-10B CTRP2 4.6469 6.8163 4.256 10.7404
Detroit 562 CTRP2 4.6599 7.1545 4.1328 11.1813
PE/CA-PJ41 (clone D2) CTRP2 4.7291 6.8621 4.3252 10.2471
BHY CTRP2 4.7761 5.9224 4.6915 8.7428
BICR 16 CTRP2 4.8405 8.2423 3.8314 11.919
SCC-4 CTRP2 4.8422 6.5821 4.5544 9.0546
SNU-1076 CTRP2 5.2035 5.9647 5.1472 5.7975
SNU-1214 CTRP2 5.2094 7.4834 4.5491 8.1073
YD-8 CTRP2 5.3775 6.8557 5.004 5.8575
BICR 6 CTRP2 5.4954 8.5933 4.2878 8.5161
HSC-4 CTRP2 5.7058 6.6459 5.4297 3.3212
SNU-899 CTRP2 6.4119 9.124 4.7991 4.5665
BICR 56 CTRP2 6.7246 11.1837 4.0172 7.2889
SNU-46 CTRP2 6.8889 13.383 3.0529 10.9439
SNU-1041 CTRP2 7.3899 10.4697 4.8273 3.0275
SNU-1066 CTRP2 7.402 10.3379 4.8959 2.7503
HSC-3 CTRP2 8.0264 10.4275 5.2013 1.0997
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 2.3456 3.2479 2.3455 24.6424
647V CTRP2 2.5498 3.3686 2.5498 23.2815
UM-UC-1 CTRP2 3.8764 5.7442 3.7531 14.8691
HT-1197 CTRP2 3.9964 5.7623 3.8796 14.0472
BC-3C CTRP2 4.0752 5.7287 3.9726 13.4727
KMBC-2 CTRP2 4.2558 6.3416 4.0039 12.8104
T24 CTRP2 4.4806 6.0849 4.3265 10.9586
TCCSUP CTRP2 5.1124 5.8438 5.0741 6.3403
JMSU-1 CTRP2 5.1209 6.2454 4.9753 6.672
SW1710 CTRP2 5.3153 7.3525 4.7149 7.1756
J82 CTRP2 5.4162 10.4985 3.2744 12.8846
CAL-29 CTRP2 5.4978 6.4874 5.2878 4.4218
253J-BV CTRP2 5.5202 6.9751 5.093 5.1411
VM-CUB-1 CTRP2 5.5353 6.9935 5.0994 5.078
5637 CTRP2 5.8032 8.0253 4.8464 5.5215
639V CTRP2 5.9702 6.7639 5.6211 1.9277
HT-1376 CTRP2 6.0932 7.7966 5.2086 3.4201
UM-UC-3 CTRP2 6.4537 7.794 5.4827 1.6781
RT-112 CTRP2 6.8182 9.5767 4.8741 3.611
RT-4 CTRP2 6.9204 8.7497 5.3334 1.661
KU-19-19 CTRP2 7.3639 8.6431 5.6114 0.3827
SCaBER CTRP2 7.9607 10.0948 5.3059 0.8425
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 6.9147 7.8628 5.7175 0.3591

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5695).
2 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.