Details of the Drug

General Information of Drug (ID: DMNVP8Q)

Drug Name
Tivantinib
Synonyms
Tivantinib; 905854-02-6; ARQ-197; ARQ197; ARQ 197; Tivantinib (ARQ 197); (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; UNII-PJ4H73IL17; PJ4H73IL17; 1000873-98-2; (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; Tivantinib [USAN:INN]; 1228508-24-4; Tivantinib; ARQ197; ARQ 197, Tivantinib; Tivantinib (ARQ-197); ARQ 197 (Tivantinib); cc-86; SCHEMBL44944; Tivantinib (JAN/USAN/INN); GTPL7948; CHEMBL2103882; CHEBI:91398; QCR-102
Indication
Disease Entry ICD 11 Status REF
Hepatocellular carcinoma 2C12.02 Phase 3 [1]
Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 369.4
Logarithm of the Partition Coefficient (xlogp) 2.9
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C23H19N3O2
IUPAC Name
(3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
Canonical SMILES
C1CC2=C3C(=CC=C2)C(=CN3C1)[C@H]4[C@@H](C(=O)NC4=O)C5=CNC6=CC=CC=C65
InChI
InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1
InChIKey
UCEQXRCJXIVODC-PMACEKPBSA-N
Cross-matching ID
PubChem CID
11494412
ChEBI ID
CHEBI:91398
CAS Number
905854-02-6
UNII
PJ4H73IL17
DrugBank ID
DB12200
TTD ID
D0ZI1F
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Hepatocellular carcinoma
ICD Disease Classification 2C12.02
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Met (MET) DTT MET 1.08E-03 -0.24 -0.4
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 0.1993 2.1138 0.1972 38.9475
JM1 CTRP2 0.3793 3.1566 0.351 37.8315
SUP-M2 CTRP2 -2.3798 -1.6771 -2.3798 56.1231
EoL-1 CTRP2 -2.2829 -1.3267 -2.2829 55.4774
KO52 CTRP2 -2.261 -1.6664 -2.261 55.3316
Pfeiffer CTRP2 -2.1304 -0.4772 -2.1304 54.4609
MOLT-3 CTRP2 -2.0842 -0.6654 -2.0842 54.154
697 CTRP2 -2.0048 -0.7548 -2.0048 53.625
BL-70 CTRP2 -1.9459 -0.4454 -1.9459 53.2324
Granta-519 CTRP2 -1.8972 2.1257 -1.9445 52.8124
A4/Fukuda CTRP2 -1.8165 -0.0662 -1.8166 52.3701
F-36P CTRP2 -1.7023 0.2676 -1.7027 51.6091
DB CTRP2 -1.5693 0.3576 -1.5696 50.7231
NU-DHL-1 CTRP2 -1.3544 1.1503 -1.3579 49.294
EJM CTRP2 -1.1933 3.3124 -1.3101 48.3079
K-562 CTRP2 -1.1041 1.267 -1.107 47.6289
GA-10 CTRP2 -1.1011 0.028 -1.1011 47.6043
SEM CTRP2 -0.8165 1.2892 -0.818 45.7121
OCI-AML-3 CTRP2 -0.7811 0.4239 -0.7811 45.4725
Mino CTRP2 -0.7004 0.9276 -0.7006 44.9354
ST486 CTRP2 -0.6427 1.42 -0.6442 44.5543
EB1 CTRP2 -0.5744 3.4367 -0.6691 44.2927
U266B1 CTRP2 -0.5363 2.039 -0.5448 43.864
AML-193 CTRP2 -0.4728 6.6712 -1.2486 44.6227
Daudi CTRP2 -0.4464 2.4057 -0.4638 43.2884
Namalwa CTRP2 -0.2724 1.5517 -0.2733 42.0863
M-07e CTRP2 -0.2328 3.0638 -0.2778 41.9412
OCI-Ly19 CTRP2 -0.2163 2.3369 -0.2269 41.741
Kasumi-2 CTRP2 -0.1998 3.4218 -0.2728 41.7917
HuNS1 CTRP2 -0.1543 3.064 -0.1962 41.4133
CMK CTRP2 -0.0709 2.3647 -0.0798 40.7682
A3/Kawakami CTRP2 0.0055 1.9074 0.0039 40.2373
CA46 CTRP2 0.0132 2.5635 0.0005 40.2198
OCI-Ly3 CTRP2 0.0758 1.5482 0.0756 39.7641
HuT 78 CTRP2 0.0761 7.6029 -0.9525 41.8704
TF-1 CTRP2 0.1154 4.1434 -0.0236 39.8858
OCI-M1 CTRP2 0.129 2.9311 0.1045 39.4845
Hs 611.T CTRP2 0.1672 4.124 0.0344 39.5302
RL CTRP2 0.2619 4.0356 0.1473 38.8588
HH [Human lymphoma] CTRP2 0.3527 3.4484 0.304 38.07
OPM-2 CTRP2 0.3761 2.0009 0.3754 37.7653
L-428 CTRP2 0.3836 4.2227 0.2518 38.1052
JeKo-1 CTRP2 0.5028 2.4979 0.4988 36.9321
MOTN-1 CTRP2 0.5197 3.173 0.495 36.8858
Kasumi-1 CTRP2 0.6296 2.7546 0.6225 36.0977
SUP-HD1 CTRP2 0.6892 4.029 0.6021 35.9537
KMS-20 CTRP2 0.7332 4.629 0.5642 35.9107
Ci-1 CTRP2 0.7947 1.9322 0.7947 34.9744
MOLP-8 CTRP2 0.949 3.4741 0.9221 34.0349
SIG-M5 CTRP2 1.0301 1.7644 1.0301 33.4062
SET-2 CTRP2 1.0564 3.1389 1.0466 33.2633
HL-60 CTRP2 1.1382 2.1446 1.1382 32.6859
LP-1 CTRP2 1.1383 3.0623 1.1318 32.7069
RPMI-6666 CTRP2 1.1566 2.2757 1.1565 32.5637
JJN-3 CTRP2 1.2366 2.4049 1.2365 32.0303
SUP-B15 CTRP2 1.2379 3.1154 1.2317 32.0423
DND-41 CTRP2 1.2488 5.5817 0.9295 32.9817
HD-MY-Z CTRP2 1.3397 6.7897 0.6888 33.3962
HEL 92.1.7 CTRP2 1.3933 2.9727 1.3911 30.9938
OCI-AML-5 CTRP2 1.526 1.9656 1.526 30.1022
Karpas-422 CTRP2 1.7917 3.2763 1.7892 28.3407
OCI-Ly10 CTRP2 2.3736 7.9476 1.3953 27.8341
Toledo CTRP2 4.2025 11.8861 1.4755 22.5496
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 -2.2223 -0.3953 -2.2224 55.0727
TE-11 CTRP2 -0.2243 2.3905 -0.2365 41.7983
EC-GI-10 CTRP2 0.2611 6.7398 -0.4698 40.2732
OE21 CTRP2 0.7475 6.2172 0.2156 36.8231
TE-14 CTRP2 1.4526 4.6891 1.3277 31.0077
TE-5 CTRP2 2.7829 7.7691 1.9007 24.8661
OE19 CTRP2 3.6536 6.9715 2.7692 13.5367
OE33 CTRP2 3.9665 9.6294 2.3216 20.0692
KYSE-150 CTRP2 4.3904 10.0746 2.5267 18.2238
KYSE-520 CTRP2 4.894 10.2297 2.9298 15.4419
KYSE-450 CTRP2 5.4042 8.7624 4.1209 9.4111
KYSE-510 CTRP2 5.4441 11.1941 2.9536 14.128
KYSE-30 CTRP2 5.8823 10.1542 3.8529 9.5228
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 3.5778 7.9148 2.2583 15.9255
MIA PaCa-2 CTRP2 0.9053 4.561 0.7602 34.7017
PaTu 8988s CTRP2 1.5738 14.5861 -2.3511 38.8352
PSN1 CTRP2 2.1049 5.8941 1.7852 27.3408
PaTu 8988t CTRP2 3.505 6.4554 3.1508 18.1744
Panc 08.13 CTRP2 3.699 12.2218 0.8349 25.9199
Panc 03.27 CTRP2 3.7464 7.8104 2.9035 18.4219
DAN-G CTRP2 3.7919 7.4618 3.0934 17.5695
KP-2 CTRP2 4.4423 10 2.6124 17.7643
PK-45H CTRP2 4.5982 13.4341 1.0846 22.9149
Capan-1 CTRP2 4.8288 10.8758 2.5535 17.0801
AsPC-1 CTRP2 4.949 9.8111 3.1852 14.2867
SW1990 CTRP2 5.1942 10.2032 3.22 13.5912
Panc 04.03 CTRP2 5.4276 8.2706 4.3831 8.2723
Capan-2 CTRP2 5.5967 11.736 2.8174 14.3526
HuP-T3 CTRP2 5.7472 13.555 2.0386 17.0463
Hs 766T CTRP2 5.7855 13.3215 2.1879 16.4091
Panc 10.05 CTRP2 5.906 12.2916 2.8048 13.771
Panc 02.03 CTRP2 7.2194 13.6934 3.1495 9.9993
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 6.4146 18.4529 0.1459 21.9485
CJM [Human melanoma] CTRP2 1.5143 3.2291 1.5096 30.1959
A2058 CTRP2 1.5431 3.4943 1.532 30.0251
IGR-37 CTRP2 1.6177 3.7174 1.5993 29.5527
IGR-1 CTRP2 2.1675 9.457 0.5638 31.0522
Hs 294T CTRP2 2.2329 6.9923 1.5921 27.6027
HMCB CTRP2 2.2496 4.9463 2.1429 25.6438
LOX-IMVI CTRP2 2.8154 6.8107 2.285 23.3887
Hs 934.T CTRP2 3.1808 11.7962 0.5351 28.1965
WM88 CTRP2 3.2057 9.0982 1.7922 24.0436
WM115 CTRP2 3.5056 9.1655 2.0693 22.2215
COLO 792 CTRP2 3.7227 8.0822 2.7647 19.0182
K029AX CTRP2 3.7724 9.3323 2.2642 20.7887
HT-144 CTRP2 3.9564 9.242 2.49 19.454
MeWo CTRP2 3.9814 7.9557 3.0874 17.0767
RVH-421 CTRP2 4.2136 7.9226 3.3417 15.4677
WM983B CTRP2 4.2606 8.9154 2.944 16.9129
COLO 800 CTRP2 4.3132 8.4388 3.2143 15.7116
UACC-62 CTRP2 4.8513 9.4944 3.2464 14.2657
Hs 895.T CTRP2 4.8798 10.0276 3.015 15.1331
COLO 829 CTRP2 4.9857 11.6487 2.3175 17.6346
SK-MEL-3 CTRP2 5.06 9.3301 3.5232 12.6546
A101D CTRP2 5.2559 10.5394 3.1102 13.9016
WM266-4 CTRP2 5.4472 11.5271 2.7907 14.774
WT2-iPS CTRP2 5.6528 11.0543 3.2061 12.6658
SK-MEL-2 CTRP2 5.8761 6.591 5.6207 2.1349
IGR-39 CTRP2 6.7746 16.3527 1.4854 17.0249
Hs 688(A).T CTRP2 6.8401 9.2352 5.0535 2.8566
UACC-257 CTRP2 7.1136 15.7486 2.052 14.3937
SK-MEL-24 CTRP2 7.1302 14.0789 2.8922 11.1667
Hs 940.T CTRP2 7.4112 15.7707 2.268 13.0829
Hs 839.T CTRP2 7.8887 12.8767 4.0159 5.5455
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 1.8672 5.8622 1.5341 28.9583
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 CTRP2 -2.2561 -0.7054 -2.2561 55.299
IMR-32 CTRP2 -2.0826 -1.3015 -2.0826 54.1434
SK-N-SH CTRP2 -1.2577 2.3025 -1.2931 48.6739
SK-N-FI CTRP2 -0.3014 3.4399 -0.3814 42.4764
SK-N-DZ CTRP2 0.4264 6.1201 -0.1075 38.8434
NH-6 CTRP2 0.8453 5.3527 0.5432 35.5664
SK-N-AS CTRP2 0.9635 6.8153 0.2713 35.8836
SK-N-BE(2) CTRP2 2.545 7.7589 1.6507 26.4483
KP-N-YN CTRP2 4.5542 9.1416 3.1284 15.4514
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 5.4922 12.5533 2.319 16.5217
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 -0.8388 0.974 -0.8392 45.8579
SK-ES-1 CTRP2 0.2055 1.9147 0.2046 38.9024
A-673 CTRP2 0.4062 1.2517 0.4062 37.5624
TC71 CTRP2 0.43 1.8751 0.4298 37.4044
SaOS-2 CTRP2 0.9372 4.7757 0.7588 34.594
HOS CTRP2 2.6915 5.3144 2.5556 22.8024
G-292 clone A141B1 CTRP2 3.5287 8.4466 2.4079 20.8998
MG-63 CTRP2 4.2742 11.5779 1.6925 21.6139
Hs 888.T CTRP2 5.8045 11.0745 3.3267 11.8614
Hs 822.T CTRP2 6.4663 12.5613 3.1306 11.3868
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 -0.2297 1.7945 -0.2317 41.8051
MDA-MB-157 CTRP2 0.1532 6.1188 -0.4054 40.5857
AU565 CTRP2 1.0315 7.9094 -0.0289 36.3884
SK-BR-3 CTRP2 1.0646 5.2631 0.8015 34.016
HCC38 CTRP2 1.9577 7.009 1.2881 29.4867
UACC-812 CTRP2 2.0038 11.7319 -0.6058 34.4969
MDA-MB-468 CTRP2 2.1298 6.8523 1.5272 28.1456
HCC1500 CTRP2 2.5153 6.3429 2.1075 24.9332
Hs 578T CTRP2 2.7964 6.2729 2.4348 22.9056
HCC2218 CTRP2 2.9763 7.5886 2.1766 23.3089
BT-549 CTRP2 2.9803 10.6153 0.8841 27.7015
MDA-MB-453 CTRP2 3.1434 9.9733 1.3396 25.7785
HCC202 CTRP2 3.451 9.9118 1.6773 23.7786
CAL-85-1 CTRP2 3.5747 11.8858 0.876 26.1143
MDA-MB-415 CTRP2 4.1269 12.4451 1.1331 23.8879
EFM-192A CTRP2 4.3528 9.2855 2.8635 16.9993
ZR-75-30 CTRP2 4.8856 7.8944 4.0372 10.9767
BT-20 CTRP2 4.9164 10.6096 2.7649 16.0473
HCC1419 CTRP2 5.398 8.15 4.414 8.212
BT-474 CTRP2 5.7422 9.8577 3.8804 9.6916
HCC1428 CTRP2 6.6554 15.1584 1.986 15.4643
T-47D CTRP2 6.9108 15.5492 1.9933 14.9702
MDA-MB-361 CTRP2 7.6513 31.0729 -5.1572 30.5144
Hs 578Bst CTRP2 8.6021 31.8889 -4.8131 28.6166
BT 416 CTRP2 -2.2701 4.6033 -2.6805 54.4872
BT 231 CTRP2 0.0635 6.642 -0.6552 41.4287
BT 145 CTRP2 0.6457 5.5031 0.2911 37.0061
BT 239 CTRP2 1.4493 4.5444 1.3453 30.96
BT 245 CTRP2 1.8549 7.3619 1.0551 30.5655
BT 428 CTRP2 2.2033 12.4999 -0.7578 34.2322
BT147 CTRP2 2.4404 13.1944 -0.8475 33.7423
BT 112 CTRP2 2.548 7.3625 1.8021 25.9124
BT 286 CTRP2 2.8269 9.1899 1.3619 26.6002
BT 172 CTRP2 3.2336 10.8293 1.0385 26.5139
BT164 CTRP2 3.3806 7.8718 2.4936 20.9869
BT 271 CTRP2 3.4156 8.7836 2.1454 22.1864
BT 224 CTRP2 4.1684 10.0492 2.3236 19.5507
BT 179 CTRP2 4.1984 10.3312 2.2191 19.8711
BT 330 CTRP2 4.3598 12.2282 1.4567 22.2314
BT 504 CTRP2 4.5991 8.8053 3.3305 14.5318
BT 422 CTRP2 4.6613 10.0743 2.7861 16.5571
BT 228 CTRP2 4.8868 10.0072 3.0314 15.0508
BT 248 CTRP2 5.1664 9.475 3.5518 12.2951
BT 482 CTRP2 5.2158 13.382 1.6641 19.5368
BT 159 CTRP2 5.3147 10.0382 3.411 12.5444
BT 498 CTRP2 5.4089 20.3229 -1.6312 28.3741
BT 139 CTRP2 5.5306 11.6128 2.8212 14.4759
BT 131 CTRP2 5.6891 13.6379 1.9476 17.5027
BT 444 CTRP2 5.7527 13.0659 2.2877 16.0981
BT 359 CTRP2 5.8816 15.1726 1.3439 19.2454
BT 216 CTRP2 6.0108 17.1492 0.4639 21.8059
BT 232 CTRP2 6.1222 14.3773 1.9426 16.6446
BT 320 CTRP2 6.1284 9.1008 4.5856 5.9715
BT 333 CTRP2 6.977 14.0616 2.784 11.8545
BT 440 CTRP2 7.1417 17.2536 1.326 16.9017
BT 328 CTRP2 8.2782 18.004 1.8086 13.3351
BT 340 CTRP2 10.3642 24.6431 0.0525 15.8117
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 -0.6758 3.1475 -0.7475 44.9136
SF539 CTRP2 -0.5628 3.0989 -0.6248 44.1552
Becker CTRP2 0.4699 3.0136 0.4513 37.1982
Hs 683 CTRP2 0.8754 4.6018 0.7216 34.9263
SF268 CTRP2 1.3227 6.633 0.7195 33.3643
YH-13 CTRP2 1.7062 4.6074 1.6109 29.2223
A-172 CTRP2 2.7101 8.2446 1.6351 26.0117
DK-MG CTRP2 3.0704 5.8526 2.849 20.5822
KG-1-C CTRP2 3.329 12.0802 0.5456 27.7656
42-MG-BA CTRP2 3.4113 12.0643 0.633 27.2877
TM-31 CTRP2 3.4231 7.4921 2.6901 20.1299
M059K CTRP2 3.6321 8.4617 2.5083 20.2404
YKG-1 CTRP2 4.1494 8.8623 2.8571 17.5368
U-118MG CTRP2 4.6557 10.0314 2.8015 16.5094
U-251MG CTRP2 4.7394 9.9674 2.9118 15.8733
T98G CTRP2 4.8309 11.9335 2.0361 19.047
GOS-3 CTRP2 4.9589 11.5921 2.3211 17.6812
SNB-75 CTRP2 5.4693 12.3479 2.4014 16.2537
KNS-42 CTRP2 6.1908 11.519 3.4281 10.6867
8-MG-BA CTRP2 6.4155 11.4814 3.6286 9.4412
CCF-STTG1 CTRP2 7.0423 12.7021 3.5062 8.8563
GMS-10 CTRP2 7.2191 15.4121 2.2999 13.2915
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA CTRP2 0.7108 5.7345 0.3053 36.7242
JHUEM-1 CTRP2 1.2532 4.4861 1.144 32.2805
JHUEM-3 CTRP2 1.3059 10.4312 -0.7462 37.0006
EN CTRP2 1.6157 8.0645 0.5408 32.887
JHUEM-7 CTRP2 1.8054 5.5971 1.5323 29.164
MFE-296 CTRP2 1.8445 6.6803 1.2727 29.9008
MFE-319 CTRP2 2.3728 4.9007 2.2819 24.7692
ESS-1 CTRP2 3.0921 5.9162 2.8566 20.4882
HEC-1-A CTRP2 4.0366 9.0565 2.6553 18.6111
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 1.2398 8.76 -0.1281 35.8902
KMRC-3 CTRP2 2.3308 7.2149 1.621 27.2013
786-O CTRP2 3.509 6.474 3.1493 18.1682
CAL-54 CTRP2 3.5875 10.6127 1.4894 24.0676
KMRC-1 CTRP2 4.0628 7.3719 3.4159 15.5844
Caki-2 CTRP2 4.1779 10.5552 2.0925 20.3959
ACHN CTRP2 4.99 8.4886 3.8614 11.4349
VMRC-RCZ CTRP2 5.3571 10.2932 3.3232 12.8121
A-498 CTRP2 5.7462 8.3848 4.6173 6.6
KMRC-2 CTRP2 6.9341 12.635 3.458 9.233
Caki-1 CTRP2 6.9797 15.8392 1.9029 15.1747
TUHR14TKB CTRP2 7.2081 9.4159 5.2013 3.9234
RCC10RGB CTRP2 7.774 14.3501 3.2298 8.8062
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
T84 CTRP2 -0.0564 3.5412 -0.1334 40.8569
GP2d CTRP2 0.1394 4.9154 -0.1305 40.0487
SW948 CTRP2 0.6489 2.4512 0.6466 35.9533
HCT 15 CTRP2 1.0661 4.9736 0.8619 33.8239
NCI-H716 CTRP2 1.4689 6.7486 0.8423 32.4987
COLO 320 CTRP2 1.6474 7.3388 0.839 31.911
SNU-C1 CTRP2 2.7067 5.4647 2.5422 22.8016
SNU-C4 CTRP2 2.722 4.4779 2.6973 22.2172
NCI-H747 CTRP2 3.4095 9.4608 1.8397 23.3145
LS1034 CTRP2 3.513 8.2429 2.4784 20.6776
HCC-56 CTRP2 3.6517 6.9587 3.1368 17.7993
SW1417 CTRP2 3.952 8.0725 3.0069 17.4679
C2BBe1 CTRP2 4.3328 10.6053 2.2174 19.5465
SNU-503 CTRP2 5.237 13.7991 1.4752 20.1538
HCT 8 CTRP2 5.4641 7.8381 4.6276 7.1786
COLO 678 CTRP2 5.6452 16.1423 0.659 21.9582
RCM-1 [Human ESC] CTRP2 6.1064 7.2275 5.5037 2.1559
SNU-1033 CTRP2 6.7919 39.5081 -10.0687 36.7473
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-4 CTRP2 0.8808 4.4541 0.7502 34.819
JHH-5 CTRP2 1.5862 6.5481 1.0327 31.5173
HLF CTRP2 1.8287 5.6289 1.5501 29.0286
JHH-1 CTRP2 2.0781 5.1064 1.9312 26.9234
SNU-423 CTRP2 2.6051 6.3094 2.2154 24.2745
HuH-1 CTRP2 3.0185 6.4721 2.6162 21.5794
JHH-2 CTRP2 3.1054 10.1593 1.2173 26.2889
PLC/PRF/5 CTRP2 3.8226 9.0084 2.4615 19.9112
SNU-449 CTRP2 4.2396 9.5431 2.6315 18.1891
SK-HEP-1 CTRP2 4.819 9.5458 3.1909 14.5659
SNU-387 CTRP2 4.961 13.1537 1.5509 20.5022
SNU-475 CTRP2 6.2379 12.513 2.9699 12.4621
JHH-6 CTRP2 6.7925 8.2732 5.4745 1.2788
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 64 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L51 CTRP2 -1.1199 3.7076 -1.2823 47.8745
DV-90 CTRP2 -1.049 3.4159 -1.1692 47.3911
NCI-H1703 CTRP2 -0.9169 1.2724 -0.9187 46.3813
NCI-H23 CTRP2 -0.8229 2.5049 -0.8551 45.8123
NCI-H522 CTRP2 -0.8118 4.1549 -1.0197 45.9822
NCI-H1341 CTRP2 -0.622 2.5035 -0.648 44.4726
NCI-H2171 CTRP2 -0.2794 5.6689 -0.7582 43.0809
NCI-H841 CTRP2 -0.2132 4.113 -0.3708 42.0712
NCI-H810 CTRP2 -0.1693 5.0784 -0.4996 42.1396
NCI-H2081 CTRP2 0.0595 5.1105 -0.2578 40.6665
NCI-H146 CTRP2 0.4487 10.6349 -1.7249 41.5523
NCI-H520 CTRP2 0.6271 4.4159 0.4842 36.5325
HCC1438 CTRP2 0.7092 4.5004 0.5592 36.0121
DMS 273 CTRP2 0.7206 5.1476 0.4524 36.2818
NCI-H1694 CTRP2 0.8121 4.9609 0.5894 35.5513
DMS 454 CTRP2 0.8405 7.0386 0.0656 36.8549
NCI-H2141 CTRP2 0.8858 9.1725 -0.6668 38.2885
HCC4006 CTRP2 0.9104 7.6878 -0.0799 36.9462
VMRC-LCD CTRP2 1.2092 6.3718 0.6747 33.8897
COR-L88 CTRP2 1.4631 8.4599 0.2266 34.2499
NCI-H1568 CTRP2 1.4734 6.0112 1.0649 31.7931
COLO 668 CTRP2 1.5285 5.1957 1.3192 30.7839
Lu-65 CTRP2 1.5705 6.8304 0.9266 31.9001
NCI-H1339 CTRP2 1.5978 3.2602 1.5936 29.6378
DMS 53 CTRP2 1.6059 5.1169 1.4186 30.1979
ChaGo-K-1 CTRP2 1.6622 9.5932 -0.0207 34.2148
LK2 CTRP2 1.6876 1.9928 1.6876 29.0257
DMS 114 CTRP2 1.7072 5.2214 1.5077 29.5668
NCI-H1944 CTRP2 1.8582 7.9194 0.8552 31.1723
RERF-LC-MS CTRP2 1.8818 3.9087 1.8618 27.7987
NCI-H2170 CTRP2 1.9377 5.6012 1.6754 28.2516
NCI-H1651 CTRP2 1.9728 9.4475 0.3648 32.2173
NCI-H1105 CTRP2 2.1154 6.6593 1.5742 28.0312
NCI-H838 CTRP2 2.3151 5.529 2.1028 25.5738
NCI-H2110 CTRP2 2.4359 5.1494 2.3097 24.4706
COR-L47 CTRP2 2.5079 10.1545 0.6126 29.8811
NCI-H2029 CTRP2 2.5864 6.7888 2.0439 24.942
LUDLU-1 CTRP2 2.6713 6.6167 2.1924 24.1549
NCI-H1693 CTRP2 2.7219 6.8734 2.1624 24.1105
SK-MES-1 CTRP2 2.7263 7.0766 2.0968 24.3326
NCI-H647 CTRP2 2.8355 9.7791 1.1135 27.3892
NCI-H322 CTRP2 2.8464 6.6873 2.3597 23.0257
LC-1/sq-SF CTRP2 2.9937 7.9503 2.0532 23.7063
NCI-H1092 CTRP2 3.1256 8.9821 1.7602 24.3806
NCI-H1623 CTRP2 3.2013 7.7666 2.3463 22.0407
T3M-10 CTRP2 3.4734 9.8673 1.7201 23.5673
COR-L95 CTRP2 4.2331 7.5665 3.5143 14.7409
COR-L105 CTRP2 4.2359 11.6776 1.608 22.0061
EKVX CTRP2 4.3239 10.1494 2.4269 18.7708
NCI-H1915 CTRP2 4.4388 8.4031 3.357 14.8254
HOP-62 CTRP2 4.646 12.774 1.4533 21.564
KNS-62 CTRP2 4.8739 8.7585 3.6208 12.6924
NCI-H2196 CTRP2 5.3152 8.4752 4.1783 9.3746
NCI-H2342 CTRP2 5.3476 9.8655 3.526 11.9991
NCI-H1869 CTRP2 5.3704 10.2593 3.3519 12.6656
RERF-LC-Ad2 CTRP2 5.3762 11.8984 2.5434 15.9015
NCI-H1395 CTRP2 5.5969 10.0605 3.6522 10.943
NCI-H1563 CTRP2 6.0294 7.0451 5.5314 2.1853
IA-LM CTRP2 6.4619 9.9478 4.4288 6.0261
NCI-H1793 CTRP2 7.0561 16.2033 1.7815 15.4739
Calu-1 CTRP2 7.1579 13.5064 3.1958 9.9161
HCC2935 CTRP2 7.2353 16.1742 1.9345 14.6085
HOP-92 CTRP2 7.3351 47.697 -13.7164 38.405
Hs 888.Lu CTRP2 4.514 11.185 2.1089 19.5168
⏷ Show the Full List of 64 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 -1.062 2.5125 -1.1027 47.3963
SYO-1 CTRP2 1.027 6.6772 0.3838 35.3547
P-STS CTRP2 2.4218 6.3621 1.9998 25.6017
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 2.0389 9.1788 0.5462 31.5034
OC 314 CTRP2 -2.0251 -0.9158 -2.0251 53.76
TOV-112D CTRP2 0.9601 5.9071 0.5327 35.182
COV434 CTRP2 1.3291 6.9602 0.6221 33.6263
JHOM-1 CTRP2 2.0381 7.9243 1.0459 30.0088
COV644 CTRP2 2.7986 8.6808 1.5488 26.0496
COV362 CTRP2 2.9568 9.4751 1.3715 26.1959
OAW42 CTRP2 3.0355 6.8608 2.5064 21.9297
OV-90 CTRP2 3.81 7.466 3.1109 17.4524
OVCAR-5 CTRP2 4.6916 11.9677 1.8915 19.9013
EFO-21 CTRP2 4.942 9.1389 3.504 13.0067
OV56 CTRP2 5.2119 10.7838 2.9496 14.6469
JHOS-2 CTRP2 5.6316 9.9302 3.7476 10.4741
OV7 CTRP2 5.8052 15.2542 1.2387 19.7576
OAW28 CTRP2 5.8558 13.9849 1.9159 17.2764
EFO-27 CTRP2 6.1873 11.2874 3.5411 10.2272
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 3.434 10.9457 1.1825 25.506
Yamato-SS CTRP2 5.9875 14.075 1.9816 16.7692
TE 617.T CTRP2 0.5681 5.3658 0.2386 37.4392
G-401 CTRP2 0.9068 4.7535 0.7299 34.7902
GCT CTRP2 0.9166 5.6414 0.553 35.2804
KYM-1 CTRP2 0.9516 5.3531 0.6588 34.846
HT-1080 CTRP2 1.0616 3.4427 1.04 33.2678
G-402 CTRP2 1.6156 6.712 1.0136 31.4797
MES-SA CTRP2 1.6711 6.4103 1.167 30.8091
TE 441.T CTRP2 1.7127 6.6361 1.1432 30.749
A-204 CTRP2 1.7629 7.2797 0.9845 31.0856
TTC-709 CTRP2 1.8854 6.152 1.4758 29.0958
SW982 CTRP2 1.9862 6.3495 1.5286 28.595
RD CTRP2 2.1364 7.4273 1.3354 28.7658
BT-16 CTRP2 2.6991 5.9717 2.4132 23.2808
SK-UT-1 CTRP2 3.0195 8.0707 2.032 23.7091
Hs 729.T CTRP2 3.2677 7.2897 2.6018 20.9023
BT-12 CTRP2 3.5875 5.7961 3.4266 16.9253
Tm87-16 CTRP2 3.593 9.1011 2.1869 21.5525
SK-LMS-1 CTRP2 4.1635 9.8596 2.4082 19.2406
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.0933 11.2842 3.4652 10.7206
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 CTRP2 2.9496 7.1466 2.3127 22.8909
JL-1 CTRP2 4.7356 8.2847 3.7078 12.6766
IST-Mes1 CTRP2 4.9008 8.6716 3.6881 12.3542
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 1.1779 4.3436 1.0828 32.7347
VCaP CTRP2 2.1268 10.0934 0.2482 32.0514
DU145 CTRP2 3.9661 7.9132 3.0896 17.109
PaCa-3 CTRP2 5.3037 9.2698 3.7793 11.0499
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 3.4266 7.8903 2.5345 20.705
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 -2.2758 -1.6917 -2.2758 55.43
NCC-StC-K140 CTRP2 -0.1681 5.2574 -0.5379 42.2066
IM95 CTRP2 0.7708 3.5625 0.7314 35.2615
HGC-27 CTRP2 1.7769 5.8467 1.4396 29.5679
SH-10-TC CTRP2 2.0492 4.2262 2.0147 26.7324
SNU-1 CTRP2 2.6182 7.282 1.9069 25.3325
SNU-216 CTRP2 2.9653 9.0101 1.5825 25.4542
SNU-601 CTRP2 2.999 8.1851 1.9639 24.0132
HuG1-N CTRP2 3.1529 6.6415 2.7076 20.8453
MKN74 CTRP2 4.4127 13.8441 0.7133 24.5307
LMSU CTRP2 4.6429 9.3991 3.0924 15.3807
Hs 746.T CTRP2 4.7389 10.6256 2.5919 17.1384
MKN7 CTRP2 4.9563 12.4889 1.8757 19.352
KATO III CTRP2 5.4161 9.4998 3.7688 10.8458
KE-39 CTRP2 6.5862 13.9809 2.5181 13.5895
SNU-685 CTRP2 3.1662 6.7704 2.6789 20.9114
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 0.8263 3.2316 0.8079 34.8243
SW579 CTRP2 1.6191 4.5712 1.5229 29.8049
FTC-133 CTRP2 5.0682 9.7143 3.3437 13.3697
TT2609-C02 CTRP2 5.3657 10.3866 3.2846 12.9516
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ49 CTRP2 -0.4991 2.3254 -0.5148 43.6344
CAL-27 CTRP2 -0.2487 1.871 -0.2516 41.9345
PE/CA-PJ34 (clone C12) CTRP2 0.3417 4.5902 0.149 38.5459
HSC-2 CTRP2 0.3434 4.6881 0.1336 38.5802
BICR 6 CTRP2 0.3608 3.6325 0.2967 38.0617
PE/CA-PJ15 CTRP2 0.9061 6.2572 0.3773 35.81
CAL-33 CTRP2 1.3243 5.1454 1.1079 32.1579
BICR 22 CTRP2 1.4342 4.2118 1.3699 30.9285
BICR 18 CTRP2 2.9818 7.2014 2.3275 22.7422
SCC-9 CTRP2 3.0167 8.0712 2.0289 23.7285
BICR 56 CTRP2 3.4146 8.7853 2.1437 22.1953
SCC-4 CTRP2 3.7229 10.7557 1.5553 23.4853
BICR 16 CTRP2 4.1046 8.9431 2.7753 17.9709
FaDu CTRP2 5.4782 10.9188 3.1206 13.3799
PE/CA-PJ41 (clone D2) CTRP2 5.624 13.4612 1.9801 17.5183
BICR 31 CTRP2 6.0748 14.8894 1.6472 17.8025
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCaBER CTRP2 1.7382 5.7161 1.4304 29.7246
647V CTRP2 1.9979 5.5358 1.7561 27.782
U-BLC1 CTRP2 2.1142 8.2732 0.9924 29.9365
BC-3C CTRP2 2.9433 8.1911 1.9029 24.3919
UM-UC-1 CTRP2 3.296 9.6027 1.6608 24.2576
T24 CTRP2 3.5259 9.2668 2.0448 22.2569
KMBC-2 CTRP2 4.4767 12.716 1.3264 22.3966
HT-1197 CTRP2 5.2979 29.0942 -6.1083 35.4136
J82 CTRP2 5.7816 12.3748 2.6577 14.6048
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 0.5398 1.865 0.5396 36.673

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7948).