Details of the Drug

General Information of Drug (ID: DMO0892)

Drug Name
PF-4708671
Synonyms PF4708671; PF 4708671
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Clinical trial [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 390.4
Logarithm of the Partition Coefficient (xlogp) 3.2
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C19H21F3N6
IUPAC Name
2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole
Canonical SMILES
CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F
InChI
InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
InChIKey
FBLPQCAQRNSVHB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
51371303
CAS Number
1255517-76-0
TTD ID
D0Y4LI
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ribosomal protein S6 kinase beta-1 (S6K1) TTG0U4H KS6B1_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 4.5049 6.4249 2.6101 2.509
NOS-1 [Human HNSCC] GDSC1 0.8583 3.5259 0.5749 32.5121
SJSA-1 GDSC1 2.5147 5.3838 1.5597 17.0606
EW-7 GDSC1 3.5534 5.3556 2.491 5.761
EW-24 GDSC1 3.7106 7.1727 1.7101 11.2769
EW-22 GDSC1 3.8207 6.0672 2.3395 6.1147
MG-63 GDSC1 4.0819 8.7317 1.2214 13.5915
MHH-ES-1 GDSC1; GDSC2 4.1541 7.4414 1.9077 6.7937
EW-16 GDSC1 4.2707 6.367 2.4987 3.7531
TC-71 GDSC1 4.3128 7.2787 2.0959 6.5931
EW-12 GDSC2 4.3302 7.24 2.1261 5.0895
SaOS-2 GDSC1 4.3414 6.2491 2.5954 2.9226
ES1 GDSC1 4.3762 6.1645 2.6534 2.4618
CHSA0011 GDSC1; GDSC2 4.4089 6.9015 2.3366 3.6955
CAL-72 GDSC1 4.4536 6.4237 2.5818 2.793
CADO-ES1 GDSC1 4.5747 10.8369 0.5505 16.3578
ES7 GDSC1 4.7196 7.6378 2.1876 4.9574
SK-ES-1 GDSC1 4.7729 7.2061 2.4143 3.3029
CHSA0108 GDSC1; GDSC2 4.7771 9.08 1.5467 7.5891
ES8 GDSC1 4.7942 6.8721 2.5716 2.2609
U-CH2 GDSC2 4.7956 8.4075 1.8773 5.6289
HuO9 GDSC1 4.8127 9.78 1.235 11.3575
H-EMC-SS GDSC1 4.8736 7.4177 2.3769 3.3623
HuO-3N1 GDSC1 5.0094 10.1718 1.1807 11.1932
A-673 GDSC1 5.0869 6.3425 2.913 0.3183
ES4 GDSC1 5.0965 11.1038 0.7923 13.4221
EW-18 GDSC1 5.1712 15.5187 -1.3123 23.5176
HOS GDSC1 5.2048 7.2916 2.6004 1.5316
EW-1 GDSC1 5.2097 7.4362 2.5438 1.8268
EW-11 GDSC1 5.2634 7.6649 2.4756 2.1347
NY GDSC1 5.4249 8.6821 2.125 3.9965
ES6 GDSC1 5.4771 7.4834 2.6469 1.0292
U2OS GDSC1; GDSC2 5.5681 12.6017 0.3942 12.2331
CHSA8926 GDSC1 5.5905 7.0819 2.8396 0.2948
CAL-78 GDSC1 5.7276 7.6378 2.6924 0.6623
EW-13 GDSC1 5.8104 7.503 2.7729 0.3733
EW-3 GDSC1 6.2659 8.4567 2.6051 0.6339
ES5 GDSC1; GDSC2 6.6341 14.9083 0.0017 12.0211
G-292 clone A141B1 GDSC1 7.8274 31.1867 -7.0572 31.1915
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 164 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 3.9224 6.5856 2.1594 5.7854
DB GDSC1 1.3621 52.1652 -22.7515 47.801
DoHH2 GDSC2 1.8112 3.75 1.5392 16.629
JURL-MK1 GDSC1 2.4095 5.1881 1.5508 17.6083
TALL-1 [Human adult T-ALL] GDSC2 2.7226 8.0494 0.4419 19.5501
MV4-11 GDSC1 2.7227 5.2024 1.8452 13.9953
EoL-1 GDSC1 2.7494 8.806 0.0893 25.3938
KM-H2 GDSC1 2.7722 8.7713 0.1265 25.1063
MM1.S GDSC1 3.0345 5.7043 1.8835 12.4034
LP-1 GDSC1; GDSC2 3.0658 5.7585 1.8841 9.8719
ATN-1 GDSC1 3.1325 8.2035 0.7215 20.2429
SIG-M5 GDSC2 3.1731 6.0311 1.8414 9.8087
ALL-PO GDSC1 3.2091 15.2846 -2.7537 33.6548
BC-1 GDSC1 3.2975 6.294 1.8155 11.9207
Ku812 GDSC1 3.3394 5.8005 2.0972 9.5854
NU-DUL-1 GDSC1; GDSC2 3.3877 4.6366 2.7185 3.6334
IM-9 GDSC1 3.4165 6.6199 1.7511 11.9794
RCH-ACV GDSC1; GDSC2 3.4743 9.3163 0.4508 17.1531
P12-Ichikawa GDSC1 3.5038 5.3093 2.4755 6.0448
NK-92MI GDSC2 3.5084 5.8422 2.2136 6.4927
SU-DHL-5 GDSC1 3.5159 7.4769 1.4038 14.2019
Karpas-299 GDSC1 3.5817 5.0693 2.6541 4.3975
SUP-T1 GDSC1 3.5837 5.4899 2.4476 6.0028
MHH-CALL-4 GDSC2 3.6022 8.4523 0.9865 13.7794
Jiyoye GDSC1 3.611 6.059 2.1862 7.9548
OPM-2 GDSC1 3.6583 5.9042 2.2993 6.9221
OCI-Ly7 GDSC1; GDSC2 3.6617 5.648 2.4285 4.7421
BC-3 GDSC2 3.668 6.1757 2.1722 6.3318
SUP-B8 GDSC1; GDSC2 3.6713 6.1034 2.2105 6.0834
697 GDSC1 3.6767 5.7369 2.3958 6.1139
AMO1 GDSC1 3.7105 5.5865 2.4949 5.2427
MOLM-16 GDSC1; GDSC2 3.7125 13.1944 -1.2927 24.3398
A3/Kawakami GDSC1 3.7176 5.4192 2.582 4.5489
TUR GDSC1 3.7266 5.6525 2.4743 5.3537
MLMA GDSC1 3.7398 5.3054 2.6532 3.9394
MOLM-13 GDSC1 3.7839 10.9601 -0.1194 22.5624
MEG-01 GDSC1 3.7902 6.2799 2.2127 7.1832
L-1236 GDSC1 3.7967 8.5721 1.0813 15.4804
THP-1 GDSC1; GDSC2 3.8112 6.1371 2.2983 5.189
Raji GDSC1 3.8191 5.3754 2.6742 3.5639
Kasumi-1 GDSC1; GDSC2 3.8234 7.7558 1.5078 10.0566
KE-37 GDSC1 3.8313 5.9887 2.3855 5.7298
OCI-Ly19 GDSC1; GDSC2 3.8454 5.9667 2.4063 4.4404
MY-M12 GDSC1; GDSC2 3.8513 6.6766 2.0627 6.5559
KMS-12-BM GDSC1 3.8538 6.7161 2.0451 8.2766
K-562 GDSC1 3.8819 7.1424 1.8559 9.6279
YT GDSC1 3.9019 6.2458 2.3106 6.1005
MOLT-13 GDSC1 3.9349 6.8203 2.0536 7.9662
OCI-M1 GDSC1 3.9364 7.1514 1.8921 9.1866
JSC-1 GDSC1 3.938 6.5597 2.1833 6.969
P31/FUJ GDSC1 3.9411 5.9138 2.4986 4.5629
HT GDSC1; GDSC2 3.9753 5.8055 2.5733 3.1429
RPMI-8402 GDSC1 3.9819 6.3101 2.3357 5.6843
MHH-PREB-1 GDSC1 3.9867 8.4301 1.2985 13.3608
KY821 GDSC1 3.9944 5.6113 2.6773 3.1019
BV-173 GDSC1 4.0008 8.6732 1.1889 14.0739
TK [Human B-cell lymphoma] GDSC1 4.0071 6.4336 2.2935 5.9346
HEL GDSC1; GDSC2 4.0203 5.502 2.7443 2.0562
CTV-1 GDSC1 4.0227 6.7603 2.146 7.0084
NB4 GDSC1; GDSC2 4.0324 5.614 2.7 2.288
Mono-Mac-6 GDSC1 4.0431 8.8217 1.1475 14.2195
ARH-77 GDSC1 4.0475 7.6295 1.7388 9.9945
HDLM-2 GDSC1 4.0598 7.059 2.0269 7.8026
SU-DHL-4 GDSC1; GDSC2 4.0634 6.5986 2.2528 4.8918
OCI-AML-2 GDSC1 4.0678 6.6124 2.2491 6.1031
U-698-M GDSC1 4.0861 5.9164 2.5928 3.5002
GDM-1 GDSC1 4.0905 6.8181 2.1655 6.6713
Karpas-620 GDSC1 4.0944 5.6342 2.7285 2.5122
CMK GDSC1 4.1055 12.2217 -0.493 23.2713
SUP-M2 GDSC1 4.1491 6.6541 2.2846 5.6201
ST486 GDSC1 4.1682 8.0726 1.6097 10.5783
Farage GDSC1; GDSC2 4.1685 6.587 2.3296 4.2054
SUP-B15 GDSC1 4.1769 8.6663 1.3245 12.5815
Karpas-45 GDSC1 4.1946 6.2775 2.4927 3.9715
L-428 GDSC1 4.2117 6.6942 2.3072 5.2907
RPMI-8226 GDSC1 4.2415 6.6632 2.3415 4.9635
NCI-H929 GDSC1 4.2534 7.3897 2.0023 7.4445
SU-DHL-16 GDSC1; GDSC2 4.2733 9.8313 0.8221 12.9307
L-363 GDSC1 4.2954 8.9825 1.2563 12.6924
QIMR-WIL GDSC1; GDSC2 4.3307 6.6992 2.3817 3.5794
RC-K8 GDSC1 4.3345 8.9597 1.2959 12.3029
LC4-1 GDSC1 4.3413 6.4188 2.518 3.4602
RS4;11 GDSC1 4.3534 6.0007 2.7131 2.1108
SU-DHL-1 GDSC2 4.3565 17.4061 -2.8777 27.6594
CML-T1 GDSC1 4.3818 7.002 2.2724 5.1262
RPMI-8866 GDSC1 4.4142 9.656 1.0127 13.9651
H9 GDSC1 4.4256 7.4567 2.0862 6.3754
CTB-1 GDSC1; GDSC2 4.4422 7.9107 1.8807 6.3218
HC-1 GDSC1 4.4464 6.1748 2.6877 2.1108
KG-1 GDSC1 4.4544 7.2574 2.1989 5.4845
EM-2 GDSC1 4.4571 6.3357 2.6229 2.5128
BALL-1 GDSC1 4.467 9.2129 1.2677 12.1065
ME1 GDSC1 4.4692 7.7681 1.967 7.1331
Daudi GDSC1 4.4863 8.9141 1.4267 10.9547
MOLT-4 GDSC1 4.4911 6.9475 2.3661 4.2042
BONNA-12 GDSC2 4.5384 7.2397 2.2602 3.8985
DEL GDSC1 4.5829 5.9289 2.8594 0.9199
KMOE-2 GDSC1 4.5892 6.6351 2.5642 2.6562
JJN-3 GDSC1 4.62 7.1691 2.3423 4.0941
SU-DHL-10 GDSC1 4.6259 5.887 2.8952 0.7041
GA-10 GDSC1 4.6489 6.6089 2.6081 2.271
Karpas-231 GDSC1 4.6516 8.0317 1.9615 6.7162
CRO-AP2 GDSC1; GDSC2 4.6574 8.9808 1.5132 8.0388
P32/ISH GDSC1 4.6692 6.0533 2.8492 0.8771
OCI-AML-3 GDSC1 4.6862 6.7425 2.5702 2.4474
BE-13 GDSC1 4.687 25.372 -6.5871 36.3156
MHH-CALL-2 GDSC1 4.687 14.4522 -1.1505 24.254
JVM-3 GDSC1 4.6993 9.9103 1.0931 12.6097
HAL-01 GDSC1 4.7057 11.2905 0.4238 16.7061
NALM-6 GDSC1 4.7199 13.2233 -0.5175 21.4912
P30/OHK GDSC1 4.7322 6.5455 2.6784 1.7164
Granta-519 GDSC1 4.7569 6.62 2.6595 1.7909
BL-41 GDSC1 4.7755 6.6281 2.6655 1.7295
SU-DHL-6 GDSC1 4.8118 6.4375 2.7613 1.1588
WSU-NHL GDSC1 4.8681 6.4719 2.7734 1.0359
CA46 GDSC1 4.8732 11.9625 0.2164 17.3772
ALL-SIL GDSC1 4.8734 6.6155 2.7182 1.31
ML-2 GDSC1 4.9042 11.2929 0.5657 15.3107
HL-60 GDSC1 4.9054 6.159 2.909 0.4312
Namalwa GDSC1 5.0034 11.2328 0.6651 14.4444
CCRF-CEM GDSC1 5.0076 7.2474 2.5222 2.2299
Jurkat GDSC1 5.0313 12.9399 -0.1475 18.8255
KCL-22 GDSC1 5.0369 7.9268 2.2429 3.9383
OCI-AML-5 GDSC1 5.0454 6.1397 2.9689 0.1926
LAMA-84 GDSC1 5.0466 8.1953 2.1283 4.6813
MOLT-16 GDSC1 5.0735 13.972 -0.6232 20.9537
MOLP-8 GDSC1 5.075 7.0388 2.6417 1.4701
Karpas-1106P GDSC1 5.0754 6.6897 2.7797 0.8077
JVM-2 GDSC1 5.0802 8.1941 2.1482 4.4819
CESS GDSC1 5.0867 7.7291 2.3572 3.1135
PF-382 GDSC1 5.1068 7.8455 2.3174 3.3308
EB2 GDSC1 5.1238 7.6291 2.4199 2.666
A4/Fukuda GDSC1 5.1385 7.2582 2.5825 1.7073
Sc-1 GDSC1 5.1669 9.613 1.5489 8.3492
PL-21 GDSC1; GDSC2 5.174 9.5239 1.595 6.5254
JeKo-1 GDSC1; GDSC2 5.177 12.7824 0.0344 14.8772
WIL2 NS GDSC1 5.1841 6.9839 2.713 1.0035
EJM GDSC1 5.201 6.9811 2.7215 0.9499
NOMO-1 GDSC1 5.2378 6.4515 2.9305 0.2119
VL51 GDSC1 5.2386 7.4204 2.5641 1.6814
MC116 GDSC1; GDSC2 5.3022 10.2974 1.3141 7.8573
Reh GDSC1 5.3959 6.6704 2.9118 0.2002
SUP-HD1 GDSC1 5.4446 7.5492 2.6072 1.2387
VAL GDSC1 5.4779 7.7133 2.5574 1.4421
L-540 GDSC1 5.5426 7.125 2.8064 0.4031
RL GDSC1; GDSC2 5.5534 11.6658 0.831 9.9952
Karpas-422 GDSC1 5.5756 7.0543 2.8437 0.2904
HH [Human lymphoma] GDSC1 5.6014 7.6273 2.6447 0.9335
SU-DHL-8 GDSC1 5.6522 8.4158 2.3552 2.286
DND-41 GDSC1 5.7305 7.4565 2.7593 0.4473
DG-75 GDSC1 5.9006 19.5193 -2.7411 26.3314
EHEB GDSC1 5.9433 8.5187 2.4485 1.4854
SK-MM-2 GDSC1 6.0071 7.6928 2.7786 0.2853
NKM-1 GDSC1 6.0488 8.2888 2.5807 0.8491
ROS-50 GDSC1; GDSC2 6.1024 12.6851 0.7049 9.591
MN-60 GDSC1 6.1413 7.9466 2.7392 0.3269
Ramos.2G6.4C10 GDSC1 6.2291 15.1047 -0.3582 16.7465
SR GDSC1 6.2463 18.3271 -1.9052 22.932
GR-ST GDSC1 6.424 25.4512 -5.2758 30.8619
KMS-11 GDSC1; GDSC2 6.9595 15.0577 0.1374 10.8049
RPMI-6666 GDSC1 7.1021 19.994 -2.1127 21.7103
WSU-DLCL2 GDSC1 7.3679 17.687 -0.8335 16.3393
SKM-1 GDSC1; GDSC2 7.7387 19.7641 -1.5738 16.4316
Loucy GDSC1 8.288 25.2053 -3.8086 24.2056
⏷ Show the Full List of 164 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1 1.2254 3.6555 0.9348 28.0758
SK-GT-4 GDSC1 4.1356 6.4104 2.3918 4.8567
KYSE-220 GDSC1 4.3726 7.2356 2.1562 5.9965
OACP4 C GDSC1 4.4971 6.6264 2.5159 3.153
FLO-1 GDSC1 4.7337 11.321 0.4293 16.5922
TE-12 GDSC1; GDSC2 4.9377 9.2713 1.562 7.1721
OACM5.1 C GDSC1 5.2575 8.6006 2.0678 4.6704
ESO-51 GDSC1 5.4171 7.6211 2.5664 1.4635
ESO-26 GDSC1 5.7811 7.39 2.8017 0.313
HCE-4 GDSC1; GDSC2 5.956 11.2952 1.2579 6.9686
KYAE-1 GDSC1 6.5599 31.6353 -8.2351 34.7961
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 5.4311 7.5606 2.5966 1.3018
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-FI GDSC1 3.4831 5.1949 2.5161 5.7947
NB69 GDSC1 3.4832 5.8374 2.1959 8.3067
SJNB-6 GDSC1; GDSC2 3.6125 5.0864 2.6686 3.3645
NB1 GDSC1 3.6513 5.8142 2.3385 6.6391
SJNB-7 GDSC1 3.8356 6.8164 1.9821 8.8137
NH-12 GDSC1 3.8507 6.3094 2.2427 6.7707
SK-N-SH GDSC1 3.8931 6.9531 1.9576 8.8229
NB(TU)1 GDSC1 3.9626 15.2077 -2.0958 29.614
SK-N-MC-IXC GDSC1; GDSC2 3.9767 5.9737 2.4941 3.6156
CHP-126 GDSC1; GDSC2 3.9813 5.78 2.5894 3.0347
SK-N-DZ GDSC1 4.0083 5.8245 2.586 3.7377
MHH-NB-11 GDSC2 4.1023 6.4461 2.3525 4.2048
KP-N-RT-BM-1 GDSC2 4.1065 6.7532 2.2079 5.0708
GI-ME-N GDSC1 4.1493 8.4602 1.4055 12.0978
KP-N-YS GDSC2 4.264 6.153 2.5932 2.4878
SJNB-17 GDSC1; GDSC2 4.2979 6.7127 2.3545 3.8003
SJNB-13 GDSC1 4.3909 6.2565 2.6207 2.6522
CHP-212 GDSC1 4.4857 6.7604 2.4485 3.6392
LA-N-6 GDSC1; GDSC2 4.6324 7.9737 1.9764 5.3683
Kelly GDSC1 5.1007 6.5984 2.8248 0.6049
SK-N-BE(2)-M17 GDSC1 5.23 7.3002 2.6087 1.4595
SK-N-AS GDSC1 5.3002 7.0435 2.7398 0.7874
SJNB-5 GDSC1; GDSC2 5.5285 13.9734 -0.2957 15.6385
KP-N-YN GDSC1 5.7276 7.7068 2.6669 0.7534
TGW GDSC1 5.7539 7.3249 2.8145 0.293
GOTO GDSC1 5.9038 8.2228 2.5456 1.0952
IMR-5 GDSC1 5.9161 14.956 -0.5007 18.1735
SJNB-10 GDSC1 5.9535 13.4254 0.2591 14.2968
SiMa GDSC1 6.0939 8.0698 2.6782 0.5038
SJNB-14 GDSC1 6.4253 17.1875 -1.2259 20.0273
SJNB-12 GDSC1 6.6314 8.3331 2.7797 0.134
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 1.0233 2.1544 1.0116 28.8063
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-453 GDSC1; GDSC2 1.8111 3.9625 1.4626 17.0034
CAL-51 GDSC1; GDSC2 1.9129 4.96 1.1575 18.3469
OCUB-M GDSC1; GDSC2 2.082 5.0774 1.2766 16.9904
UACC-893 GDSC1; GDSC2 2.8381 8.1745 0.4815 18.8962
CAL-148 GDSC2 3.4568 5.5591 2.3136 5.9813
MDA-MB-175-VII GDSC1; GDSC2 3.467 5.0648 2.5682 4.3515
ZR-75-30 GDSC1; GDSC2 3.5541 5.2098 2.5638 4.1514
DU4475 GDSC1; GDSC2 3.5613 6.3308 2.012 7.5931
HCC2218 GDSC1; GDSC2 3.6119 6.8369 1.7999 8.7821
HCC1500 GDSC1; GDSC2 3.7084 6.5092 2.0378 7.0456
MDA-MB-468 GDSC1; GDSC2 3.8004 5.8519 2.4301 4.3825
Evsa-T GDSC1; GDSC2 3.8151 5.6036 2.5614 3.5439
HCC1599 GDSC2 3.9971 5.9139 2.5363 3.3083
MRK-nu-1 GDSC1; GDSC2 4.0462 6.6551 2.2135 5.1515
BT-474 GDSC1; GDSC2 4.0518 6.8309 2.1322 5.6343
HCC1395 GDSC1; GDSC2 4.1019 6.6093 2.2741 4.6629
MDA-MB-361 GDSC1; GDSC2 4.1403 6.3102 2.4424 3.5777
COLO 824 GDSC1; GDSC2 4.2382 7.7325 1.8257 7.0764
YMB-1-E GDSC2 4.2941 11.0001 0.2599 15.8992
CAMA-1 GDSC1; GDSC2 4.3013 8.1383 1.6731 7.8528
HDQ-P1 GDSC1; GDSC2 4.345 6.4838 2.4904 2.9182
HCC70 GDSC1; GDSC2 4.3753 7.9777 1.8027 6.9096
MDA-MB-157 GDSC1; GDSC2 4.3939 6.572 2.4796 2.8945
HCC1187 GDSC1; GDSC2 4.424 7.058 2.273 4.0222
HCC202 GDSC1 4.4312 6.9126 2.3453 4.4855
CAL-120 GDSC1; GDSC2 4.4366 11.3453 0.1971 15.8084
MDA-MB-415 GDSC2 4.4778 6.6952 2.4735 2.7872
HCC2157 GDSC1 4.5502 6.4333 2.6313 2.2916
MCF-7 GDSC1; GDSC2 4.5736 8.7743 1.5552 7.947
BT-20 GDSC1; GDSC2 4.5756 9.9136 1.0035 11.1359
JIMT-1 GDSC1; GDSC2 4.5811 7.004 2.3943 3.0545
HCC1428 GDSC1; GDSC2 4.6139 8.5192 1.7051 6.9782
MDA-MB-436 GDSC1; GDSC2 4.6196 6.4385 2.666 1.5679
EFM-192A GDSC1; GDSC2 4.7086 8.8213 1.6244 7.2538
CAL-85-1 GDSC1; GDSC2 4.7213 7.3146 2.336 3.1461
HCC38 GDSC1; GDSC2 4.749 9.2338 1.4541 8.1601
T-47D GDSC1; GDSC2 4.7545 9.8432 1.1642 9.8149
HCC1419 GDSC1; GDSC2 4.7715 10.6663 0.7765 11.9422
EFM-19 GDSC1; GDSC2 4.7873 8.058 2.0352 4.7193
HCC1143 GDSC1; GDSC2 4.8912 7.3109 2.4336 2.3731
Hs 578T GDSC1; GDSC2 4.9309 7.6702 2.2971 3.0289
HCC1937 GDSC1; GDSC2 5.0707 8.7014 1.9122 4.9092
MFM-223 GDSC1; GDSC2 5.0722 9.1933 1.6852 6.1849
HCC1569 GDSC1; GDSC2 5.406 16.0391 -1.3945 20.4082
MDA-MB-231 GDSC1; GDSC2 5.458 7.8296 2.5017 1.3971
AU565 GDSC1; GDSC2 5.5327 11.0635 1.102 8.5507
HCC1806 GDSC1; GDSC2 5.5459 7.0126 2.8474 0.2344
BT-483 GDSC1; GDSC2 5.602 7.5498 2.6743 0.6524
HCC1954 GDSC1; GDSC2 5.7208 12.7781 0.4127 11.7886
MDA-MB-330 GDSC2 5.8605 14.4929 -0.3156 14.972
BT-549 GDSC1; GDSC2 5.8794 13.875 -0.0054 13.5017
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Becker GDSC1 0.8445 1.3059 0.8445 30.9673
LN-405 GDSC1 3.4867 13.7586 -1.7598 30.0914
PFSK-1 GDSC1 3.6375 5.3172 2.5735 4.8534
T98G GDSC1 3.8876 5.3214 2.7452 2.8618
NMC-G1 GDSC1; GDSC2 3.9125 6.3337 2.2754 5.0928
U-87MG ATCC GDSC1 3.917 5.3487 2.7512 2.7473
GB-1 GDSC1 3.9452 5.7443 2.5825 3.9228
D-423MG GDSC1; GDSC2 3.9794 9.7269 0.6495 14.6541
42-MG-BA GDSC1 4.0173 7.0699 1.9911 8.1964
D-247MG GDSC1; GDSC2 4.1177 6.2337 2.4639 3.5079
D-245MG GDSC2 4.254 8.1269 1.6449 8.1588
GaMG GDSC1 4.2824 12.0562 -0.2728 21.6765
D-336MG GDSC1; GDSC2 4.3126 9.0195 1.2507 10.3707
ONS-76 GDSC1 4.3544 7.3266 2.1009 6.4486
SF126 GDSC1; GDSC2 4.3926 7.4342 2.075 5.2661
A-172 GDSC1 4.4773 8.9703 1.3931 11.2143
GI-1 GDSC1 4.5071 7.2684 2.2272 5.1562
D-502MG GDSC1; GDSC2 4.5529 7.0263 2.3673 3.2635
Onda 11 GDSC1; GDSC2 4.5533 8.7345 1.5604 7.9876
M059J GDSC1 4.5952 9.4802 1.2286 12.0035
D-542MG GDSC1; GDSC2 4.6302 6.5128 2.6397 1.6899
LN-229 GDSC1 4.6762 8.4877 1.7618 8.0786
Onda 10 GDSC1; GDSC2 4.7613 7.2656 2.3812 2.8483
8-MG-BA GDSC1 4.8789 9.4229 1.4511 9.7242
SW1783 GDSC1 4.9361 7.4988 2.3758 3.2559
LN-18 GDSC1 5.0049 6.0466 2.9865 0.1679
D-263MG GDSC1 5.0148 8.7974 1.8335 6.7612
CAS-1 GDSC1 5.0515 6.8849 2.6926 1.2361
U-118MG GDSC1 5.0875 9.7192 1.4478 9.2207
KNS-81-FD GDSC1; GDSC2 5.0909 10.9467 0.8641 10.7827
KS-1 [Human Krukenberg tumour] GDSC1 5.1011 9.8221 1.4081 9.4535
AM-38 GDSC1 5.139 14.0144 -0.5959 20.6494
D-566MG GDSC1; GDSC2 5.1508 7.1958 2.6138 1.2249
SF539 GDSC1 5.169 10.8142 0.9809 12.0601
D283 Med GDSC1 5.1739 12.3605 0.2376 16.4179
SW1088 GDSC1 5.2282 9.3427 1.7129 7.1027
D-392MG GDSC1 5.2832 12.8218 0.0907 16.9076
SF295 GDSC1; GDSC2 5.2838 12.7039 0.1483 14.079
SK-MG-1 GDSC1 5.3587 9.3025 1.8102 6.1711
LNZTA3WT4 GDSC1 5.4218 6.838 2.8629 0.3042
KINGS-1 GDSC1 5.6307 11.6978 0.8664 11.6114
MOG-G-UVW GDSC1 5.7057 7.6595 2.6756 0.7364
DK-MG GDSC1 5.7072 28.2751 -7.2268 35.1109
YH-13 GDSC1 5.7084 13.5891 0.0154 16.1858
DBTRG-05MG GDSC1 5.7427 7.5265 2.7389 0.5019
YKG-1 GDSC1; GDSC2 5.8651 13.1778 0.3183 12.0001
SF268 GDSC1 5.9019 7.8892 2.6693 0.6341
SNB-75 GDSC1; GDSC2 6.0632 8.0063 2.6892 0.3912
MOG-G-CCM GDSC1 6.2647 8.1873 2.7004 0.3724
U-251MG GDSC1 6.3741 14.0429 0.2416 13.4076
KALS-1 GDSC1 6.4658 8.8252 2.5493 0.6994
Daoy GDSC1 6.4682 13.2934 0.6505 10.9706
H4 GDSC1 6.7878 27.2546 -5.893 31.2168
KNS-42 GDSC1; GDSC2 7.1352 14.6321 0.4401 9.0904
Hs 683 GDSC1; GDSC2 8.7503 20.7355 -1.3841 14.0558
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 0.8678 1.4061 0.8678 30.6761
ETK-1 GDSC1 4.4111 6.9995 2.2922 4.9135
TGBC24TKB GDSC1 5.9245 7.8202 2.703 0.5156
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC1 4.1597 8.028 1.6253 10.4901
EN GDSC1 4.18 5.9289 2.6452 2.9137
MFE-296 GDSC1 4.8616 6.787 2.642 1.7436
MFE-280 GDSC1 5.1517 7.2768 2.5812 1.6975
ESS-1 GDSC1 5.2804 6.7562 2.8385 0.4427
AN3-CA GDSC1 5.8876 8.0617 2.5998 0.8918
MFE-319 GDSC1 8.3026 22.6744 -2.5844 20.8018
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 1.9595 3.3065 1.8392 17.8187
SW13 GDSC1 3.1222 6.0143 1.8059 12.6566
LB2241-RCC GDSC1; GDSC2 3.2168 12.1415 -1.1758 25.3368
KMRC-1 GDSC1 3.5445 5.0355 2.6428 4.602
UO-31 GDSC1; GDSC2 3.8142 6.6651 2.0408 6.7838
CAL-54 GDSC1 3.9712 6.4697 2.2508 6.359
VMRC-RCW GDSC2 3.99 8.4704 1.281 10.9942
KTCTL-13 GDSC1; GDSC2 4.003 6.2265 2.3905 4.1861
HA7-RCC GDSC1; GDSC2 4.1409 6.979 2.1228 5.5129
BFTC-909 GDSC1 4.1811 5.8132 2.6985 2.5396
KTCTL-26A GDSC1; GDSC2 4.2466 7.4693 1.9591 6.2732
KMRC-20 GDSC1 4.3274 6.1353 2.6385 2.6556
KTCTL-195 GDSC1 4.4739 6.2058 2.6891 2.0548
KTCTL-1M GDSC1; GDSC2 4.534 8.1934 1.8073 6.5654
BB65-RCC GDSC1; GDSC2 4.5543 6.737 2.4992 2.5323
TK-10 GDSC1 4.6106 7.704 2.0892 5.9021
ACHN GDSC1 4.6286 9.4701 1.257 11.718
NCC021 GDSC1; GDSC2 4.7343 6.8072 2.5679 1.9118
KTCTL-140 GDSC1; GDSC2 4.8509 10.0228 1.1443 9.7471
NCC010 GDSC1; GDSC2 4.9128 6.8631 2.6357 1.3723
Caki-1 GDSC1; GDSC2 5.0304 11.5495 0.5303 12.7063
OS-RC-2 GDSC1 5.0465 9.4301 1.5577 8.5779
SN12C GDSC1 5.1176 7.1471 2.6179 1.544
RCC10RGB GDSC1 5.1604 10.3426 1.2002 10.6779
A-498 GDSC1 5.2617 13.8218 -0.4123 19.469
LB1047-RCC GDSC1; GDSC2 5.293 10.4537 1.2345 8.3185
KTCTL-21 GDSC1; GDSC2 5.3199 7.4935 2.5727 1.2369
SW156 GDSC1; GDSC2 5.5478 12.2351 0.556 11.4487
LB996-RCC GDSC1 5.7686 18.0714 -2.1264 24.8067
RXF 393L GDSC1; GDSC2 5.7733 13.0174 0.3335 12.1118
769-P GDSC1 8.4962 19.4428 -0.9431 14.5965
VMRC-RCZ GDSC1 9.392 27.3151 -4.0709 22.9185
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo GDSC1 3.0341 4.2434 2.6038 6.7995
SW620 GDSC1; GDSC2 3.5988 5.7009 2.3545 5.3656
CW-2 GDSC1 3.6438 5.4076 2.5337 5.1436
CCK-81 GDSC1 3.7919 6.0468 2.3285 6.2847
SNU-81 GDSC1; GDSC2 3.8441 6.339 2.2234 5.5756
HT-29 GDSC1; GDSC2 3.8812 5.5428 2.6359 2.9614
SW1463 GDSC1 3.8815 5.505 2.6541 3.5516
T84 GDSC1 3.9548 7.0072 1.9764 8.4933
SK-CO-1 GDSC1 4.0254 5.7438 2.6351 3.3362
SW1116 GDSC1 4.0526 7.9499 1.5851 11.1077
SNU-C2B GDSC1 4.0547 7.3654 1.8736 8.9695
LS123 GDSC1 4.1175 6.9742 2.1088 7.0229
C2BBe1 GDSC1 4.1727 6.3964 2.4228 4.5351
SNU-61 GDSC1 4.181 8.0726 1.619 10.4727
HCT 116 GDSC1 4.2397 7.7983 1.7948 9.0166
SNU-407 GDSC1 4.2479 6.0618 2.6251 2.9098
HCT 15 GDSC1 4.2777 6.526 2.4291 4.2374
LS411N GDSC1 4.3396 6.4866 2.4858 3.6907
HT115 GDSC1; GDSC2 4.344 7.5602 1.9822 5.9228
NCI-H747 GDSC1 4.457 6.4241 2.5835 2.7746
COLO 678 GDSC1 4.4575 6.9161 2.3599 4.3223
SNU-C1 GDSC1 4.5602 14.0203 -1.0336 24.1655
SW1417 GDSC1 4.5781 6.3212 2.6945 1.8513
COLO205 GDSC1 4.7093 12.8804 -0.3561 20.7715
NCI-H508 GDSC1; GDSC2 4.8318 6.6161 2.6982 1.1796
HT-55 GDSC1 4.8561 6.1821 2.8804 0.5713
KM12 GDSC1 4.9725 6.8292 2.6783 1.4007
SNU-283 GDSC2 4.9922 7.3049 2.4898 1.9658
SW48 GDSC1 5.1217 7.1515 2.618 1.5383
SW948 GDSC1 5.1503 6.6958 2.8087 0.6304
HCC2998 GDSC1 5.1808 9.5624 1.5813 8.0979
LS1034 GDSC1 5.224 6.4416 2.9289 0.2202
DiFi GDSC1 5.3469 7.3577 2.6388 1.1876
SW837 GDSC1 5.3688 11.1763 0.9416 11.7952
RKO GDSC1 5.4068 6.9941 2.8013 0.4903
GP5d GDSC1 5.4219 7.1171 2.7622 0.614
LS180 GDSC1 5.4439 6.962 2.8272 0.3914
COLO 320HSR GDSC1 5.6707 7.296 2.7939 0.3784
LS513 GDSC1 5.7165 7.1598 2.8581 0.2116
MDST8 GDSC1 6.1427 12.7789 0.6866 11.4784
CaR-1 GDSC1 6.1734 18.0336 -1.8141 22.7921
SNU-C5 GDSC1 6.1868 7.8738 2.7806 0.2272
SW626 GDSC1 6.2843 8.1702 2.7135 0.3348
CL-11 GDSC1 6.3524 12.6824 0.8614 10.0131
NCI-H716 GDSC1 6.7284 26.8914 -5.7583 31.1058
RCM-1 [Human ESC] GDSC1 7.0986 18.5595 -1.4257 19.2867
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.277 6.1525 2.6012 3.0154
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2/C3A GDSC1 3.4882 5.159 2.538 5.6054
HuH-1 GDSC1 3.588 6.1151 2.1404 8.3873
Hep 3B2.1-7 GDSC1; GDSC2 3.6233 8.0239 1.2171 12.3568
Huh-7 GDSC1 3.7754 5.4914 2.5879 4.3382
JHH-2 GDSC1 3.861 5.8636 2.4675 5.0179
JHH-1 GDSC1 3.8869 6.3989 2.2251 6.7989
SNU-449 GDSC1 4.2668 6.4368 2.4639 4.0114
JHH-6 GDSC1 4.4244 9.4582 1.1171 13.2466
JHH-4 GDSC1 4.5072 11.3401 0.2527 18.262
SK-HEP-1 GDSC1 4.5237 7.2432 2.2494 4.9597
HLE GDSC1 4.7321 7.7945 2.1231 5.382
JHH-7 GDSC1 4.753 11.2195 0.493 16.1689
SNU-423 GDSC1 5.7699 7.41 2.7906 0.3448
SNU-398 GDSC1 6.1971 7.9341 2.7636 0.2568
SNU-387 GDSC1 6.2577 7.8045 2.8285 0.1349
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 185 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC78 GDSC1 0.8302 9.7187 -2.133 41.4494
COLO 668 GDSC1 2.8384 3.6528 2.6777 7.1562
NCI-H1651 GDSC1 2.9415 7.3395 0.988 19.2827
NCI-H748 GDSC2 3.3617 6.3548 1.8385 9.2681
BEN GDSC1; GDSC2 3.428 7.5772 1.282 12.5191
DMS 273 GDSC1 3.435 5.0318 2.5593 5.6176
NCI-H1755 GDSC1 3.4354 5.4364 2.3577 7.2018
NCI-H1105 GDSC2 3.4409 6.8966 1.6328 10.3281
NCI-H510A GDSC1; GDSC2 3.4706 4.7765 2.7145 3.4344
Calu-6 GDSC1 3.4752 4.8275 2.6927 4.4345
NCI-H1876 GDSC1 3.4918 5.889 2.1771 8.4246
NCI-H661 GDSC1 3.5014 10.2498 0.0064 22.9182
NCI-H2342 GDSC1 3.5247 6.9482 1.6749 12.1734
NCI-H2171 GDSC2 3.5552 5.8921 2.2257 6.2906
NCI-H250 GDSC2 3.6283 6.8904 1.7862 8.854
NCI-H841 GDSC1 3.6393 5.5501 2.46 5.731
ABC-1 GDSC1; GDSC2 3.647 7.0587 1.7171 9.2339
NCI-H345 GDSC1; GDSC2 3.6499 4.6289 2.9174 1.7498
A-427 GDSC1; GDSC2 3.6651 7.6431 1.4403 10.8918
NCI-H1944 GDSC1 3.6652 5.3709 2.5676 4.8152
NCI-H2795 GDSC1 3.6676 5.6929 2.4107 6.0264
SBC-1 GDSC1; GDSC2 3.6713 5.2784 2.6173 3.5424
KNS-62 GDSC1 3.6773 9.1816 0.6827 18.4672
COR-L303 GDSC2 3.714 6.6757 1.9595 7.5451
HCC33 GDSC2 3.7155 9.0509 0.7784 14.656
DMS 53 GDSC1 3.7181 7.232 1.6864 11.4288
DMS 114 GDSC1 3.7567 5.5414 2.5504 4.6793
Lu-165 GDSC1 3.8226 5.6773 2.5309 4.6412
COR-L95 GDSC1 3.8354 5.6054 2.5746 4.2729
VMRC-LCD GDSC1 3.836 5.5395 2.6068 4.0272
A-549 GDSC1 3.8513 5.8256 2.4791 4.956
NCI-H1155 GDSC1 3.8634 6.4932 2.1618 7.3536
NCI-H2369 GDSC1 3.8773 5.5596 2.6252 3.7788
NCI-H1623 GDSC1 3.8792 7.4124 1.7205 10.6523
NCI-H2196 GDSC2 3.8895 6.1526 2.3472 4.7033
IST-SL1 GDSC1; GDSC2 3.8933 5.774 2.5332 3.5565
NCI-H2591 GDSC1 3.899 5.7133 2.5662 4.1653
IA-LM GDSC1 3.9197 5.7773 2.5496 4.2358
NCI-H1993 GDSC1 3.9361 6.8033 2.0628 7.8932
NCI-H226 GDSC1 3.9431 6.018 2.4499 4.9256
SBC-5 GDSC1 3.96 5.6109 2.6555 3.3442
NCI-H2081 GDSC1; GDSC2 3.9735 9.222 0.8957 13.2886
DMS 79 GDSC1; GDSC2 4.002 6.7918 2.1159 5.8684
HCC366 GDSC1; GDSC2 4.0026 5.6985 2.6417 2.6831
Lu-65 GDSC1 4.0194 7.2906 1.8846 8.992
NCI-H2172 GDSC1; GDSC2 4.0402 6.8684 2.1058 5.8422
IST-SL2 GDSC1; GDSC2 4.0403 5.8814 2.5799 2.9741
NCI-H146 GDSC1; GDSC2 4.0533 6.7479 2.1735 5.3982
NCI-H2804 GDSC1; GDSC2 4.0646 8.4724 1.3364 10.4741
NCI-H740 GDSC2 4.0649 7.5247 1.803 7.6429
PC-14 GDSC1; GDSC2 4.0988 6.2922 2.4236 3.7856
NCI-H526 GDSC1 4.0999 7.9818 1.6043 10.8229
NCI-H1355 GDSC1 4.1326 8.435 1.4055 12.1494
NCI-H1341 GDSC1 4.143 6.0291 2.5761 3.4883
NCI-H1975 GDSC1 4.1545 6.2781 2.4667 4.2572
LCLC-103H GDSC1 4.1685 6.1404 2.5402 3.6883
COR-L88 GDSC1 4.1686 8.5438 1.3786 12.2282
NCI-H3255 GDSC1; GDSC2 4.1723 7.9098 1.6923 8.0633
NCI-H1436 GDSC1; GDSC2 4.1752 6.3435 2.4493 3.4807
NCI-H211 GDSC1 4.177 7.1047 2.087 7.0219
SHP-77 GDSC1 4.202 5.8626 2.6885 2.5659
NCI-H1048 GDSC1 4.2115 7.5458 1.8976 8.3375
NCI-H2731 GDSC1 4.2148 6.6116 2.3484 4.9788
NCI-H1304 GDSC1 4.2189 7.3074 2.0182 7.421
NCI-H1770 GDSC1; GDSC2 4.2218 6.8137 2.2571 4.5297
NCI-H650 GDSC1 4.2332 5.9971 2.6459 2.7963
NCI-H2135 GDSC1; GDSC2 4.2516 12.7779 -0.6554 20.3242
NCI-H2444 GDSC1; GDSC2 4.263 7.3209 2.0419 5.7368
LOU-NH91 GDSC1 4.2634 7.2391 2.0815 6.8298
NCI-H1573 GDSC1 4.2648 5.8246 2.7416 2.0852
NCI-H187 GDSC1 4.2791 7.4963 1.9686 7.6243
NCI-H2170 GDSC1 4.2833 7.4079 2.014 7.2771
LB647-SCLC GDSC1; GDSC2 4.2933 6.4545 2.4721 3.1252
NCI-H1688 GDSC1 4.2939 6.4821 2.4597 3.9792
NCI-H3122 GDSC1 4.2963 6.482 2.4613 3.9627
NCI-H810 GDSC1 4.3118 6.1681 2.6146 2.8501
COR-L321 GDSC1; GDSC2 4.3564 9.1341 1.2264 10.4077
ChaGo-K-1 GDSC1; GDSC2 4.3887 6.5326 2.4944 2.83
UMC-11 GDSC1 4.4346 9.884 0.9157 14.5314
EMC-BAC-2 GDSC1 4.4501 6.9082 2.3591 4.3447
SBC-3 GDSC1 4.4576 6.8174 2.4055 3.9999
NCI-H1781 GDSC1 4.4635 5.8905 2.8181 1.2912
NCI-H1694 GDSC1 4.4823 5.9371 2.808 1.323
NCI-H1092 GDSC1 4.4941 6.5129 2.565 2.8277
HARA [Human squamous cell lung carcinoma] GDSC1 4.497 8.7014 1.5374 10.1484
LK-2 GDSC1 4.5054 6.5357 2.5612 2.8311
NCI-H2818 GDSC1 4.5345 8.2823 1.765 8.424
EMC-BAC-1 GDSC1; GDSC2 4.5419 8.0864 1.8636 6.2149
NCI-H1435 GDSC1 4.5523 6.9974 2.3802 3.9738
NCI-H1869 GDSC1 4.5629 6.3068 2.6928 1.8861
COR-L279 GDSC1 4.5663 9.6823 1.1096 12.8801
COR-L23 GDSC1 4.5731 7.7312 2.0525 6.2549
LC-1/sq GDSC1 4.5938 10.9865 0.491 16.6493
NCI-H1581 GDSC1 4.5946 6.5518 2.6037 2.3913
NCI-H2595 GDSC1 4.6026 6.3407 2.6989 1.7872
NCI-H196 GDSC1 4.6171 8.6739 1.6332 9.1438
SK-MES-1 GDSC1 4.6347 8.3431 1.803 7.8911
NCI-H290 GDSC1; GDSC2 4.6353 8.1335 1.9029 5.7934
HCC44 GDSC1 4.6564 19.0956 -3.4822 31.2437
NCI-H1650 GDSC1 4.6661 8.5315 1.7342 8.3006
NCI-H358 GDSC1 4.6807 6.6655 2.6006 2.2651
Ms-1 GDSC1 4.6925 6.869 2.5184 2.7685
NCI-H2722 GDSC1 4.6941 7.7541 2.1183 5.5017
LC-2/ad GDSC1; GDSC2 4.7137 7.0961 2.4297 2.6605
LXF 289 GDSC1 4.723 11.4585 0.354 17.0516
NCI-H1666 GDSC1 4.7343 6.9467 2.5072 2.7665
NCI-H520 GDSC1 4.735 7.2799 2.3596 3.7407
NCI-H23 GDSC1 4.7506 7.2044 2.4024 3.4239
LCLC-97TM1 GDSC1 4.7551 7.4308 2.3033 4.0836
NCI-H2803 GDSC1; GDSC2 4.7977 11.1952 0.5372 13.2076
NCI-H1836 GDSC1; GDSC2 4.8004 6.4224 2.762 0.9378
NCI-H838 GDSC1; GDSC2 4.8225 6.4116 2.7766 0.8586
NCI-H1563 GDSC1 4.831 7.1719 2.4615 2.8907
NCI-H2029 GDSC1; GDSC2 4.8428 7.2418 2.4373 2.4302
NCI-H2347 GDSC1 4.8459 8.8895 1.6827 8.2084
NCI-H2373 GDSC1 4.848 6.4658 2.7666 1.091
NCI-H69 GDSC1 4.8709 7.6536 2.2702 4.0761
NCI-H1437 GDSC1; GDSC2 4.8711 9.0322 1.6317 6.9033
NCI-H2141 GDSC1 4.873 6.6023 2.7234 1.2836
NCI-H522 GDSC1 4.8761 7.9244 2.1507 4.8779
RERF-LC-Sq1 GDSC1 4.8794 9.0696 1.6194 8.5652
SW1271 GDSC1 4.8855 7.087 2.5274 2.3865
NCI-H1793 GDSC1 4.9048 12.5543 -0.0507 18.6963
RERF-LC-MS GDSC1; GDSC2 4.9587 9.2008 1.609 6.8599
CAL-12T GDSC1; GDSC2 4.9687 10.9126 0.796 11.4237
NCI-H720 GDSC1 4.9793 6.0045 2.9919 0.1648
NCI-H847 GDSC1 4.982 6.7284 2.7232 1.1602
NCI-H1838 GDSC1 4.9986 6.9028 2.6608 1.4618
NCI-H209 GDSC1 5.0144 10.0083 1.2623 10.6432
NCI-H2461 GDSC1 5.0424 8.2686 2.0927 4.929
COR-L32 GDSC2 5.0676 7.1651 2.5865 1.427
NCI-H524 GDSC1 5.0752 7.3231 2.5245 2.1177
NCI-H2009 GDSC1 5.0764 6.8687 2.7104 1.1223
RERF-LC-KJ GDSC1 5.0771 6.3628 2.9019 0.3555
CPC-N GDSC1 5.0885 7.2023 2.5813 1.7781
NCI-H1792 GDSC1 5.0887 6.8728 2.7143 1.0912
Lu-135 GDSC1 5.0926 7.072 2.6365 1.4762
NCI-H2227 GDSC1; GDSC2 5.1066 6.7108 2.7849 0.6096
NCI-H2066 GDSC1 5.1131 6.8417 2.7372 0.9608
HOP-92 GDSC1 5.1268 7.8499 2.3263 3.2399
Calu-3 GDSC1 5.1529 10.8112 0.9714 12.1619
HCC15 GDSC1 5.1889 10.6722 1.0621 11.4947
NCI-H727 GDSC1 5.219 7.6002 2.4805 2.1679
NCI-H82 GDSC1 5.2247 7.0567 2.7025 1.0129
NCI-H441 GDSC1 5.2301 6.9705 2.7381 0.8523
NCI-H2122 GDSC1 5.2305 6.4503 2.9283 0.2194
NCI-H2110 GDSC1; GDSC2 5.234 11.3473 0.7692 10.9879
NCI-H2087 GDSC1 5.2608 7.1801 2.6703 1.126
EKVX GDSC1; GDSC2 5.271 9.6667 1.5894 6.3772
NCI-H1734 GDSC1; GDSC2 5.3092 6.9916 2.7631 0.553
NCI-H1693 GDSC1 5.3355 16.299 -1.5745 24.0429
NCI-H2023 GDSC1 5.3393 7.0138 2.7672 0.652
Lu-134-A GDSC1; GDSC2 5.3469 7.5975 2.5433 1.3333
NCI-H460 GDSC1; GDSC2 5.3571 9.7926 1.5844 6.2486
EPLC-272H GDSC1 5.408 7.5108 2.606 1.281
NCI-H2228 GDSC1 5.4368 7.4367 2.6475 1.0628
NCI-H2810 GDSC1; GDSC2 5.4601 11.3312 0.9284 9.6612
NCI-H64 GDSC1 5.4806 6.7444 2.9165 0.1666
Lu-139 GDSC1 5.4816 14.8376 -0.7503 20.4049
SK-LU-1 GDSC1 5.4992 7.8703 2.5045 1.6828
NCI-H1299 GDSC1 5.5129 11.5477 0.8604 11.9351
NCI-H292 GDSC1; GDSC2 5.5249 16.1649 -1.3689 20.0894
Lu-99A GDSC1 5.5712 7.6263 2.6323 1.0105
NCI-H446 GDSC1 5.6457 7.3546 2.7635 0.478
NCI-H835 GDSC1 5.6694 7.6772 2.6542 0.8431
NCI-H2869 GDSC1; GDSC2 5.7001 7.7996 2.6208 0.7645
NCI-H1568 GDSC1 5.7159 14.0451 -0.1994 17.2469
NCI-H2405 GDSC1 5.7189 11.0232 1.2383 9.1069
NCI-H596 GDSC1 5.8106 12.6939 0.5124 13.2472
SW1573 GDSC1 5.8251 12.4604 0.6325 12.5258
NCI-H1963 GDSC1 5.828 7.5114 2.7765 0.3569
HCC827 GDSC1 5.831 7.6073 2.7436 0.4437
COR-L105 GDSC1 5.8491 13.0657 0.3611 13.9966
NCI-H2291 GDSC1; GDSC2 5.859 12.757 0.5143 11.03
NCI-H2030 GDSC1; GDSC2 5.8765 14.9005 -0.5014 15.8016
NCI-H1648 GDSC1 5.9114 17.0012 -1.4981 22.2987
HOP-62 GDSC1 5.9282 7.4466 2.835 0.1966
NCI-H1915 GDSC1 5.9564 7.3441 2.8793 0.1209
NCI-H513 GDSC1 6.0269 7.8881 2.7176 0.4258
NCI-H2085 GDSC1 6.0745 8.0785 2.6677 0.5442
NCI-H1703 GDSC1 6.0969 8.466 2.5342 0.99
NCI-H322M GDSC1 6.4424 8.5029 2.6552 0.4132
EBC-1 GDSC1 6.6919 17.7364 -1.3069 19.7306
NCI-H647 GDSC1; GDSC2 6.8191 15.1833 -0.0093 11.7312
PaCa-3 GDSC1 7.6407 21.8957 -2.6588 22.3144
⏷ Show the Full List of 185 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.4285 6.829 2.3824 4.2276
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC1 0.2702 2.6769 0.1428 38.8171
TE-8 GDSC1 3.4379 6.6733 1.7419 11.9732
TE-15 GDSC1 3.8 8.0804 1.3284 13.7625
T.T GDSC1 3.9062 5.7962 2.5314 4.4087
KYSE-520 GDSC1 4.0165 7.5339 1.763 9.9093
TE-11 GDSC1; GDSC2 4.0234 5.5626 2.7182 2.1997
TE-6 GDSC1 4.2319 9.1258 1.1391 13.6822
KYSE-150 GDSC1 4.3905 10.4613 0.5989 16.6297
TE-1 GDSC1 4.4329 9.1153 1.2908 12.0477
EC-GI-10 GDSC1 4.4807 7.159 2.2617 4.9707
TE-5 GDSC1 4.5413 6.0964 2.7708 1.4537
TE-4 GDSC1 4.595 6.9194 2.4407 3.4689
KYSE-510 GDSC1; GDSC2 4.8304 7.542 2.297 3.1959
OE33 GDSC1 5.0748 7.4702 2.4622 2.4864
COLO 680N GDSC1 5.1417 11.7068 0.5321 14.8497
OE21 GDSC1 5.1826 7.4639 2.5192 1.999
KYSE-410 GDSC1 5.1828 7.142 2.6502 1.3034
KYSE-450 GDSC1 5.521 6.7098 2.9423 0.1151
KYSE-70 GDSC1 5.8868 7.6571 2.7469 0.4089
KYSE-180 GDSC1 6.0431 7.4836 2.8624 0.1281
KYSE-270 GDSC1 6.1012 7.9366 2.728 0.3683
TE-10 GDSC1; GDSC2 7.1871 14.5627 0.5025 8.7115
TE-9 GDSC1 7.2331 19.4192 -1.7466 20.1761
KYSE-140 GDSC1 7.6086 20.1393 -1.8385 19.7193
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RMG-I GDSC1 3.3147 10.8986 -0.4725 25.8901
Caov-3 GDSC2 3.4157 6.9511 1.5849 10.6976
A2780 GDSC1 3.4494 8.5987 0.789 18.6199
OVK18 GDSC1; GDSC2 3.47 8.5497 0.8304 15.0598
OAW42 GDSC1 3.7015 4.9725 2.7875 3.0221
JHOS-4 GDSC1; GDSC2 3.7163 5.6279 2.4788 4.2954
OVCAR-5 GDSC1 3.8958 6.1919 2.3325 5.9506
FU-OV-1 GDSC1 3.9506 6.389 2.2755 6.2294
SK-OV-3 GDSC1 3.9549 5.415 2.7441 2.7103
ES-2 GDSC1 3.9692 6.2729 2.3449 5.6497
OVCAR-8 GDSC1 4.0426 6.0718 2.4913 4.3539
TOV-112D GDSC1 4.1748 8.6985 1.307 12.7096
IGROV-1 GDSC1 4.2074 9.9724 0.7027 16.5724
JHOS-2 GDSC1; GDSC2 4.2456 5.8478 2.7204 1.8162
EFO-27 GDSC1; GDSC2 4.3626 7.3733 2.0841 5.2732
OVCAR-4 GDSC1 4.4406 8.2179 1.7319 8.9149
OVTOKO GDSC1 4.6941 9.698 1.1924 11.9676
DOV13 GDSC1 4.7617 9.9399 1.1224 12.2425
Kuramochi GDSC1 4.8013 6.7958 2.6079 2.0304
OV-90 GDSC1 4.8537 7.4061 2.3709 3.4382
OAW28 GDSC1 4.9125 9.554 1.411 9.91
OVISE GDSC1 5.0111 11.4742 0.5534 15.0839
OVCAR-3 GDSC1 5.1422 11.8234 0.476 15.1722
OV56 GDSC1 5.1667 6.4909 2.8902 0.3449
OC 314 GDSC1 5.3048 10.9211 1.0207 11.4626
TOV-21G GDSC1 5.5172 13.6793 -0.1609 17.5709
OVKATE GDSC1 6.0368 7.6044 2.8195 0.1963
EFO-21 GDSC1 6.101 12.5335 0.7749 11.0621
TYK-nu GDSC1 6.153 17.3785 -1.5095 21.7527
Caov-4 GDSC1 6.4194 8.4617 2.6612 0.4076
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 3.6016 5.0586 2.6742 4.1803
Capan-1 GDSC1 3.6411 5.375 2.5477 5.0429
YAPC GDSC1 3.9237 5.3594 2.7504 2.7373
SUIT-2 GDSC1 4.1988 6.7654 2.2647 5.6386
MIA PaCa-2 GDSC1 4.2298 7.6598 1.8551 8.6
SU.86.86 GDSC1 4.2818 7.257 2.0854 6.7522
PSN1 GDSC1 4.2957 6.3127 2.5391 3.4105
Panc 10.05 GDSC1 4.2965 6.2507 2.5679 3.2061
HPAF-II GDSC1 4.3994 9.2016 1.2246 12.5979
CFPAC-1 GDSC1 4.4372 6.2584 2.6459 2.3977
KP-2 GDSC1 4.4566 5.8671 2.8244 1.2649
Panc 02.03 GDSC1 4.5016 8.053 1.8527 7.8784
PL4 GDSC1 4.5317 6.8677 2.427 3.692
HuP-T3 GDSC1 4.9 8.3553 1.9672 6.0951
QGP-1 GDSC1; GDSC2 4.9883 6.6599 2.7532 0.8097
KP-3 GDSC1 5.0145 7.0043 2.6269 1.6238
Panc 08.13 GDSC1 5.2475 12.278 0.3294 15.7138
Hs 766T GDSC1 5.2927 7.6345 2.5025 1.946
AsPC-1 GDSC1 5.3461 10.3457 1.3196 9.4441
HuP-T4 GDSC1 5.507 7.0584 2.8167 0.3909
DAN-G GDSC1 5.5888 13.8904 -0.2131 17.6412
MZ-PC-1 GDSC1; GDSC2 5.8109 13.2471 0.249 12.4526
PaTu 8902 GDSC1 5.8853 17.0311 -1.5315 22.4854
Capan-2 GDSC1 5.9276 8.033 2.6267 0.7645
KP-1N GDSC1 6.0611 7.9654 2.703 0.4498
BxPC-3 GDSC1 6.1181 8.5023 2.5293 0.9931
Panc 03.27 GDSC1 6.1655 7.5849 2.8702 0.0983
SW1990 GDSC1 6.3053 8.0239 2.7712 0.2133
HPAC GDSC1 6.6482 19.1863 -2.0382 22.4565
PaTu 8988t GDSC1 6.6862 17.1292 -1.0192 18.5959
Panc 04.03 GDSC1 7.9207 20.1128 -1.6199 18.3112
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 3.9708 8.2968 1.3524 13.0334
NCI-H28 GDSC1 4.2974 11.7247 -0.0968 20.7599
NCI-H2052 GDSC1 4.4804 6.5221 2.553 2.9342
NCI-H2452 GDSC1 5.3078 8.1353 2.2993 3.1082
MPP 89 GDSC1 5.3342 7.3696 2.6285 1.2489
MSTO-211H GDSC1 5.6543 7.6139 2.6717 0.787
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC1 4.1321 8.7493 1.2503 13.235
LNCaP clone FGC GDSC1 4.2197 7.5345 1.9088 8.2313
NCI-H660 GDSC2 4.3544 6.3859 2.5409 2.6273
PC-3 GDSC1 5.2826 9.3686 1.7343 6.8395
VCaP GDSC1 5.6521 7.1544 2.8368 0.2784
DU145 GDSC1 6.5308 13.2057 0.7292 10.3956
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.2649 6.3016 2.5253 3.5757
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-MEL1 GDSC1 0.5037 2.9884 0.3306 36.2072
G-361 GDSC1 0.5173 1.3164 0.517 35.06
WM793 GDSC1 0.9781 3.039 0.8354 30.1957
UACC-257 GDSC1 3.3172 7.9762 0.9908 17.7983
Mel JuSo GDSC1 3.5288 7.8981 1.2039 15.5721
COLO 792 GDSC1 3.6476 5.2623 2.6079 4.5557
SK-MEL-5 GDSC1; GDSC2 3.6551 5.9544 2.272 5.7393
LB373-MEL-D GDSC1; GDSC2 3.7834 5.4494 2.6139 3.3058
G-mel GDSC1; GDSC2 3.8431 6.222 2.2799 5.2274
SK-MEL-1 GDSC1 3.9177 5.8049 2.535 4.3508
SK-MEL-28 GDSC1; GDSC2 3.9353 6.3411 2.288 4.9628
SK-MEL-30 GDSC1; GDSC2 3.9758 5.7363 2.6065 2.9441
COLO 783 GDSC2 4.0372 6.1277 2.461 3.6883
A-431 GDSC1; GDSC2 4.0687 7.0414 2.0418 6.1696
451Lu GDSC1; GDSC2 4.1015 10.8127 0.2048 16.6869
UACC-62 GDSC1 4.1024 7.9832 1.6054 10.8076
WT2-iPS GDSC1; GDSC2 4.1088 6.3419 2.4067 3.8665
MZ-MEL-7 GDSC1; GDSC2 4.1111 6.3204 2.4184 3.792
Mel Ho GDSC1; GDSC2 4.1719 5.8467 2.6779 2.169
Hs 940.T GDSC1; GDSC2 4.1719 6.0869 2.5673 2.7986
SK-MEL-31 GDSC1; GDSC2 4.199 6.3975 2.4392 3.4941
SK-MEL-24 GDSC1 4.2067 5.7906 2.7237 2.3159
DJM-1 GDSC1; GDSC2 4.2138 7.3088 2.0139 6.0137
RPMI-7951 GDSC1 4.22 5.9043 2.6802 2.5865
COLO 679 GDSC1 4.2715 7.5053 1.959 7.7161
VMRC-MELG GDSC1; GDSC2 4.2876 6.0658 2.6467 2.151
SH-4 GDSC1 4.3618 8.8187 1.3846 11.6076
A-375 GDSC1; GDSC2 4.4229 8.7598 1.4569 8.8932
CP66-MEL GDSC1; GDSC2 4.449 5.9206 2.7982 1.1458
LB2518-MEL GDSC1; GDSC2 4.4542 6.0294 2.7547 1.3482
RVH-421 GDSC1; GDSC2 4.4715 7.4419 2.1231 4.8231
MMAc-SF GDSC1; GDSC2 4.4736 9.9021 0.9353 11.8001
M14 GDSC1 4.568 9.3849 1.2557 11.8975
CP50-MEL-B GDSC1; GDSC2 4.6152 13.7365 -0.8508 20.2118
CHL-1 GDSC1 4.7348 7.2755 2.3615 3.7286
SK-MEL-2 GDSC1 4.7435 5.8334 2.9642 0.3434
GAK GDSC1 4.7992 6.0374 2.9112 0.4945
IGR-1 GDSC1 4.9055 9.2761 1.5386 9.057
A2058 GDSC1 4.9513 6.2417 2.8968 0.4444
HT-144 GDSC1 4.999 9.4675 1.5092 9.024
SK-MEL-3 GDSC1; GDSC2 5.0075 6.2002 2.9336 0.2389
Hs 938.T GDSC1; GDSC2 5.0196 6.3125 2.8979 0.3208
HMV-II GDSC1 5.043 8.1549 2.1444 4.5807
A101D GDSC1 5.0685 6.4239 2.8764 0.4415
COLO 829 GDSC1 5.1282 9.9634 1.359 9.7142
COLO 800 GDSC1; GDSC2 5.2336 6.9717 2.7391 0.6785
IGR-37 GDSC1 5.356 6.6796 2.8942 0.253
A-388 GDSC1; GDSC2 5.3835 12.9537 0.0972 14.1078
WM278 GDSC1 5.5727 7.6673 2.6173 1.0736
LOX-IMVI GDSC1 5.6317 7.3218 2.7699 0.4659
MeWo GDSC1 5.782 9.5784 1.9279 4.609
WM35 GDSC1 5.869 7.6958 2.7264 0.4745
WM115 GDSC1 6.0847 14.0891 0.0302 15.1816
MZ-MEL-2 GDSC1; GDSC2 6.102 8.1246 2.6617 0.4401
WM1552C GDSC1 6.1785 8.0337 2.7225 0.3522
IPC-298 GDSC1; GDSC2 6.733 15.8335 -0.3706 13.5098
EquiPSC Line K2 GDSC1; GDSC2 5.4918 8.0813 2.4151 1.7408
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 3.5578 5.2251 2.559 4.1867
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-LMS-1 GDSC1 3.0735 5.3446 2.0968 10.5944
TE 441.T GDSC2 3.338 4.9178 2.5373 4.9211
HT-1080 GDSC1 3.4445 5.358 2.4041 6.8055
GCT GDSC1 3.8443 7.7255 1.5388 12.1043
SW684 GDSC1 3.9505 6.4165 2.2621 6.3317
G-402 GDSC1 3.9658 6.1047 2.4237 5.0625
Hs 633.T GDSC1 3.9801 7.5359 1.7351 10.228
EW-8 GDSC1 4.2063 6.6771 2.3118 5.2704
MES-SA GDSC1 4.2092 5.631 2.7961 1.8294
VA-ES-BJ GDSC1 4.2907 8.1473 1.6612 9.8461
STS-0421 GDSC1; GDSC2 4.3466 6.6059 2.435 3.2419
SK-UT-1 GDSC1 4.4265 6.0884 2.7146 1.974
Rh41 GDSC1 4.4779 6.3437 2.6309 2.4222
MFH-ino GDSC1 4.5077 8.0495 1.8584 7.8209
SW982 GDSC1 4.5559 13.7484 -0.902 23.6449
G-401 GDSC1 4.6002 9.045 1.443 10.5233
RD GDSC1 4.6897 7.2733 2.3362 3.9918
RKN GDSC1 4.815 6.6142 2.6907 1.5323
Rh30 GDSC1 4.8206 7.8543 2.1495 5.0042
Rh18 GDSC1 5.3523 12.1644 0.457 14.7185
A-204 GDSC1 5.7166 10.6992 1.3865 8.1734
KYM-1 GDSC1 6.2107 19.3584 -2.4348 24.7142
SW872 GDSC1 7.1095 18.4363 -1.3594 19.0104
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1 1.9054 5.2796 1.0069 23.8702
Fu97 GDSC1 2.6288 4.1633 2.2414 11.4163
SNU-1 GDSC1 3.4494 5.2201 2.4768 6.217
ECC12 GDSC2 3.6257 6.5184 1.9692 7.7158
HGC-27 GDSC1 3.6387 8.0705 1.2062 15.1685
IM95 GDSC1 3.8216 5.797 2.472 5.0944
MKN45 GDSC1 3.9482 7.5096 1.7244 10.4061
SCH GDSC1; GDSC2 3.979 6.5203 2.2317 5.2091
TGBC11TKB GDSC1 3.9811 8.1684 1.4237 12.4946
23132/87 GDSC1 4.01 6.2395 2.3891 5.2045
MKN28 GDSC1 4.0805 6.874 2.1315 6.955
GCIY GDSC1 4.1413 6.8866 2.1676 6.5158
RF-48 GDSC1 4.4125 7.4957 2.059 6.6074
AGS GDSC1 4.4413 6.1168 2.7102 1.9761
SNU-16 GDSC1 4.4524 10.4979 0.627 16.2708
OCUM-1 GDSC1 4.5372 6.6683 2.5202 3.0453
SK-GT-2 GDSC1 4.6353 7.295 2.2939 4.3978
NUGC-4 GDSC1 4.6566 6.5853 2.6224 2.1693
ECC10 GDSC1 4.7181 10.3435 0.8957 13.8266
NCI-N87 GDSC1 4.7255 8.0224 2.0131 6.1733
MKN1 GDSC1 4.8011 6.6395 2.6735 1.648
Hs 746.T GDSC1 4.8279 7.4828 2.3221 3.8114
NUGC-3 GDSC1 4.8526 11.8534 0.2548 17.2259
TMK-1 GDSC1; GDSC2 5.1488 10.1844 1.2677 8.4218
SNU-5 GDSC1 5.472 6.7961 2.8958 0.2096
RERF-GC-1B GDSC1 5.6425 8.6776 2.2413 2.9414
KATO III GDSC1 6.8722 21.1045 -2.8124 24.3552
MKN7 GDSC1; GDSC2 8.5475 21.4439 -1.8423 15.991
SNG-M GDSC1 4.4733 7.355 2.1652 5.6832
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 3.385 5.1179 2.4759 6.4468
BHT-101 GDSC1 3.7671 15.2265 -2.2636 30.6856
B-CPAP GDSC1 3.8924 6.2943 2.2802 6.3608
TT GDSC1 4.0186 6.8182 2.1149 7.256
CAL-62 GDSC1 4.2677 7.1158 2.1435 6.3589
WRO GDSC1 4.4706 8.467 1.6324 9.5468
8505C GDSC1 4.5027 8.2977 1.7361 8.7162
KMH-2 GDSC1; GDSC2 4.5488 7.6888 2.0567 5.0616
K5 GDSC1 4.5635 13.2268 -0.6377 22.4951
HTC-C3 GDSC1 4.9537 10.4104 1.0282 12.3294
FTC-133 GDSC1 5.28 12.5229 0.2335 16.1523
ML-1 [Human leukemia] GDSC1; GDSC2 5.372 7.6778 2.5227 1.396
ASH-3 GDSC1 5.5106 6.7533 2.924 0.146
CGTH-W-1 GDSC1 5.6179 6.9321 2.9009 0.1592
TT2609-C02 GDSC1 5.998 8.295 2.5577 0.9726
8305C GDSC1 6.3642 16.6367 -1.0023 19.2705
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 GDSC1 2.0978 3.6291 1.8911 16.6884
SAS GDSC1 3.4051 7.8515 1.126 16.5577
FaDu GDSC1 3.5154 7.8056 1.2392 15.3737
PCI-38 GDSC1 3.6033 7.7158 1.3548 14.2459
Ca9-22 GDSC1 3.7891 7.799 1.4598 12.8592
BHY GDSC1; GDSC2 3.8168 7.1298 1.813 8.1932
BICR 22 GDSC1 3.9555 8.7853 1.0987 14.8339
SCC-9 GDSC1 3.9973 7.8867 1.575 11.3528
OSC-19 GDSC1; GDSC2 4.115 6.0421 2.5523 2.9918
NCI-H3118 GDSC1 4.1166 6.5223 2.3258 5.3972
CAL-33 GDSC1 4.1363 6.2359 2.4749 4.2412
SCC-4 GDSC1 4.1764 13.3291 -0.9886 25.1539
BICR 31 GDSC2 4.1827 5.9836 2.6217 2.4675
SAT [Human HNSCC] GDSC1 4.2055 13.4494 -1.0256 25.2095
PCI-06A GDSC1; GDSC2 4.3408 8.4039 1.5719 8.3969
DOK GDSC1 4.3462 11.6492 -0.0219 20.2242
UPCI-SCC-090 GDSC1 4.357 6.6829 2.4058 4.2223
LB771-HNC GDSC1 4.3643 6.2505 2.6081 2.7898
BICR 78 GDSC1 4.3674 6.7505 2.3808 4.377
SCC-25 GDSC1; GDSC2 4.3831 6.8796 2.3305 3.7785
BB49-HNC GDSC1 4.3833 7.0158 2.2669 5.1627
CAL-27 GDSC1 4.4323 6.6443 2.4696 3.6051
HO-1-N-1 GDSC1 4.5923 10.4368 0.7596 15.0424
JHU-022 GDSC1 4.7089 7.2094 2.3762 3.6805
HO-1-u-1 GDSC1 4.7372 7.1815 2.405 3.432
Detroit 562 GDSC1 4.7544 11.2526 0.4778 16.2525
KON GDSC1; GDSC2 4.8612 6.8914 2.598 1.6052
JHU-029 GDSC1; GDSC2 4.9316 7.0776 2.5552 1.7248
BB30-HNC GDSC1; GDSC2 4.9377 7.4483 2.3988 2.4951
HSC-3 GDSC1 5.0831 6.3668 2.9028 0.35
BICR 10 GDSC1 5.1381 6.8882 2.7301 0.9694
SCC-15 GDSC1 5.2574 7.1997 2.661 1.1727
SKN-3 GDSC1 5.3455 7.5989 2.5421 1.6679
PCI-30 GDSC1 5.4852 7.5434 2.6272 1.1087
PCI-15A GDSC1; GDSC2 5.5484 15.4562 -1.0045 18.6261
PCI-04B GDSC1; GDSC2 5.5566 12.1081 0.6227 11.0848
PE/CA-PJ15 GDSC1; GDSC2 5.6968 10.4972 1.4672 6.2939
KOSC-2 GDSC1; GDSC2 6.365 14.659 -0.0553 12.7965
HSC-4 GDSC1 6.5797 15.3228 -0.2291 15.3174
OSC-20 GDSC1 6.7307 20.076 -2.4123 23.4726
JHU-011 GDSC1; GDSC2 6.8807 16.9638 -0.8098 15.086
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V GDSC1 2.9032 7.5605 0.8443 20.3804
639V GDSC1 3.7879 5.7056 2.4926 5.0332
KU-19-19 GDSC1 3.7986 7.6222 1.555 12.1358
UM-UC-3 GDSC1 3.8807 5.7555 2.5334 4.4622
CAL-29 GDSC1 4.1532 9.7062 0.7934 16.1817
SW780 GDSC1 4.2381 6.9758 2.1906 6.0868
BFTC-905 GDSC1 4.2445 6.7251 2.3141 5.1569
T24 GDSC1; GDSC2 4.3518 6.7427 2.3747 3.5807
5637 GDSC1 4.3855 6.7701 2.3831 4.3197
HT-1197 GDSC1 4.4738 9.086 1.3343 11.6304
SW1710 GDSC1 4.7427 15.2079 -1.4825 25.3328
J82 GDSC1 4.893 7.6959 2.264 4.0741
HT-1376 GDSC1 5.2259 6.857 2.7794 0.6877
RT-112 GDSC1 5.3951 10.8496 1.1139 10.6497
RT-4 GDSC1 5.496 7.5133 2.6435 1.0273
TCCSUP GDSC1 6.8777 14.9226 0.1492 12.787
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DSH1 GDSC1 3.136 8.7482 0.4524 21.8498
HEY GDSC1 3.502 5.3932 2.4322 6.3906
OVMIU GDSC1 3.6471 5.974 2.2562 7.2937
KGN GDSC1 3.7149 6.5246 2.0351 8.789
C-33 A GDSC1 3.7313 6.5216 2.0491 8.6285
TC-YIK GDSC1 3.8375 7.4006 1.6947 10.9774
SKG-IIIa GDSC1 3.8996 5.5023 2.6675 3.406
SW756 GDSC1 3.966 5.843 2.5493 4.1172
OVCA420 GDSC1 3.9926 6.0679 2.4597 4.7194
PWR-1E GDSC1 4.1432 6.4958 2.3562 5.1013
NT2-D1 GDSC1 4.1491 5.8597 2.6582 2.8886
HT-3 GDSC1 4.1495 5.9249 2.6284 3.0989
UWB1.289 GDSC1; GDSC2 4.2482 6.4767 2.4335 3.4333
SW962 GDSC1; GDSC2 4.2648 6.1214 2.608 2.4032
PA-1 GDSC1 4.4537 6.6906 2.4612 3.618
HeLa GDSC1 4.4886 6.3848 2.6188 2.4818
LB831-BLC GDSC1 4.5604 8.8811 1.4945 10.2738
JEG-3 GDSC1; GDSC2 4.603 12.1399 -0.0703 16.7553
SW954 GDSC1; GDSC2 4.6432 7.0466 2.4114 2.8694
ME-180 GDSC1 4.6648 6.8825 2.497 2.9584
HEC-1 GDSC1 4.7242 8.4765 1.7986 7.6968
BPH-1 GDSC1 4.7687 12.2862 -0.0191 18.9288
OV17R GDSC1; GDSC2 4.8136 7.546 2.2854 3.286
DoTc2 4510 GDSC1 4.882 7.0584 2.5378 2.3289
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.9446 6.8845 2.6424 1.3084
C-4-I GDSC1 4.9614 6.5296 2.7922 0.8547
SiHa GDSC1 5.0867 6.5592 2.8337 0.5813
SKN GDSC1 5.1178 10.6903 1.0056 12.0377
CAL-39 GDSC1 5.1575 8.8396 1.9013 5.984
JHOS-3 GDSC1; GDSC2 5.2402 7.687 2.4548 1.8362
OVCA433 GDSC1; GDSC2 5.34 9.9643 1.4941 6.782
NEC8 GDSC1 5.404 6.8013 2.8692 0.2953
JAR GDSC1; GDSC2 5.5024 11.9429 0.6652 10.9748
SiSo GDSC1 5.5319 7.3537 2.7189 0.697
MS751 GDSC1 5.5438 6.9457 2.8699 0.2415
ACC-OV7 GDSC1; GDSC2 5.6784 13.1922 0.1857 13.0384
PEO1 GDSC1 6.0711 8.0589 2.6734 0.5289
Ca Ski GDSC1 6.3547 8.352 2.6758 0.397
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.