Details of the Drug

General Information of Drug (ID: DMO1234)

• Drug Name: TNX-102
• Synonyms: Cyclobenzaprine very low dose

Indication

Disease Entry	ICD 11	Status	REF
Fibromyalgia	MG30.01	Phase 3	[1]
Post-traumatic stress disorder	6B40	Phase 3	[2]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 311.8
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 3
  Hydrogen Bond Donor Count; 1
  Hydrogen Bond Acceptor Count; 1
• Chemical Identifiers:
  Formula: C20H22ClN
  IUPAC Name: N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)propan-1-amine;hydrochloride
  Canonical SMILES: CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31.Cl
  InChI: InChI=1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H
  InChIKey: VXEAYBOGHINOKW-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 22576
  ChEBI ID: CHEBI:3997
  CAS Number: 6202-23-9
  TTD ID: D0NN8N
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Antagonist	[3]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Antagonist	[3]

Molecular Expression Atlas of This Drug

• The Studied Disease: Fibromyalgia
• ICD Disease Classification: MG30.01

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017946)
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of Tonix Pharmaceuticals.