Details of the Drug

General Information of Drug (ID: DMO2S6T)

Drug Name
MOXIFETIN HYDROGEN MALEATE
Synonyms VUFB-15468; 2-(3-Hydroxyphenylsulfanyl)-N,N-dimethylbenzylamine hydrogen maleate; 3-[2-(Dimethylaminomethyl)phenylsulfanyl]phenol hydrogen maleate
Indication
Disease Entry ICD 11 Status REF
Mood disorder 6A60-6E23 Terminated [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 375.4
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 5
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Chemical Identifiers
Formula
C19H21NO5S
IUPAC Name
(Z)-4-hydroxy-4-oxobut-2-enoate;[2-(3-hydroxyphenyl)sulfanylphenyl]methyl-dimethylazanium
Canonical SMILES
C[NH+](C)CC1=CC=CC=C1SC2=CC=CC(=C2)O.C(=C\\C(=O)[O-])\\C(=O)O
InChI
InChI=1S/C15H17NOS.C4H4O4/c1-16(2)11-12-6-3-4-9-15(12)18-14-8-5-7-13(17)10-14;5-3(6)1-2-4(7)8/h3-10,17H,11H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
YLZUWDVZEDYTBB-BTJKTKAUSA-N
Cross-matching ID
PubChem CID
6918142
TTD ID
D0I9UH

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Not Available [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Mood disorder
ICD Disease Classification 6A60-6E23
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serotonin transporter (SERT) DTT SLC6A4 8.76E-01 7.18E-05 6.19E-04
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001731)
2 Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models. Folia Parasitol (Praha). 2014 Dec;61(6):561-70.