Details of the Drug

General Information of Drug (ID: DMO8PT9)

Drug Name
MLN8237
Synonyms Alisertib
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 3 [1]
Small-cell lung cancer 2C25.Y Phase 2 [2]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 518.9
Logarithm of the Partition Coefficient (xlogp) 5
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C27H20ClFN4O4
IUPAC Name
4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid
Canonical SMILES
COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
InChI
InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
InChIKey
ZLHFILGSQDJULK-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
24771867
ChEBI ID
CHEBI:125628
CAS Number
1028486-01-2
UNII
T66ES73M18
DrugBank ID
DB05220
TTD ID
D0S4JK
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aurora kinase A (AURKA) TTPS3C0 AURKA_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [4]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Gene/Protein Processing [5]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Gene/Protein Processing [4]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [4]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Gene/Protein Processing [4]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Gene/Protein Processing [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aurora kinase A (AURKA) DTT AURKA 9.41E-46 -1.78 -2.05
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 4.0808 9.5916 0.7949 13.5765
ES7 GDSC1; GDSC2 -4.0489 0.6808 -4.1848 58.8507
ES8 GDSC1; GDSC2 -3.8396 -0.5331 -3.8652 57.9906
EW-12 GDSC2 -3.5563 1.7095 -3.8137 64.4916
SK-ES-1 GDSC1; GDSC2; CTRP2 -3.4376 0.2349 -3.449 62.808
ES5 GDSC2 -3.2537 4.9918 -4.3709 52.3698
EW-18 GDSC1; GDSC2 -3.1037 7.7616 -5.2561 51.2673
SK-PN-DW GDSC1; GDSC2 -2.6877 11.1782 -6.2971 49.5082
CADO-ES1 GDSC1; GDSC2 -2.6118 4.0073 -3.3531 48.6862
EW-22 GDSC1; GDSC2 -1.9312 4.3755 -2.7298 44.2962
ES1 GDSC1; GDSC2 -1.9179 3.0802 -2.3323 52.0584
SK-N-MC CTRP2 -1.8889 2.6507 -1.9759 52.7049
MHH-ES-1 GDSC1; GDSC2; CTRP2 -0.0905 6.9436 -0.9163 42.506
EW-7 GDSC1; GDSC2 0.0847 6.8974 -1.568 32.6307
MG-63 GDSC1; GDSC2; CTRP2 0.2033 6.5247 -0.4675 40.5032
TC-71 GDSC1; GDSC2 0.3824 13.7995 -4.531 38.1016
EW-16 GDSC1; GDSC2 0.7083 11.1184 -2.9228 34.106
CAL-78 GDSC1; GDSC2; CTRP2 1.0131 7.8231 -0.0175 36.4272
EW-3 GDSC1; GDSC2 1.9341 12.1691 -2.3055 28.8577
SaOS-2 GDSC1; GDSC2; CTRP2 2.1999 10.9503 -0.0553 32.6139
EW-24 GDSC1; GDSC2 2.7512 11.0688 -1.0368 22.4011
TC71 CTRP2 3.0379 15.217 -1.2377 32.9437
H-EMC-SS GDSC2 3.0813 10.7827 -0.6109 19.8663
NY GDSC1; GDSC2 3.3056 6.0808 1.9289 7.1911
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 3.4499 10.577 1.37 24.8401
CAL-72 GDSC1; GDSC2 3.7684 11.6406 -0.4715 17.6291
CHSA0011 GDSC2 3.8853 11.1972 -0.1566 19.0574
CHSA8926 GDSC1; GDSC2 3.901 13.2066 -1.1465 20.0022
HuO-3N1 GDSC1; GDSC2 3.9406 6.1629 2.3782 3.5672
A-673 GDSC1; GDSC2; CTRP2 4.0094 14.5074 0.0167 27.5194
U-CH2 GDSC2 4.1 15.8943 -2.3282 26.7464
ES6 GDSC1; GDSC2 4.5856 9.3103 1.3043 7.7011
EW-1 GDSC1; GDSC2 5.2166 17.4173 -2.2158 20.8847
CHSA0108 GDSC2 5.2286 11.9816 0.4598 12.6303
U2OS GDSC1; GDSC2 5.5632 18.5303 -2.5048 21.1019
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.6005 19.526 -2.9684 22.3734
EW-11 GDSC2 5.6211 16.1824 -1.3074 17.0305
ES4 GDSC1; GDSC2 5.8361 16.6264 -1.3692 16.8525
Hs 822.T CTRP2 6.2244 7.9649 5.2297 3.0922
HOS GDSC1; GDSC2; CTRP2 6.3287 13.1787 2.7113 13.3176
HuO9 GDSC1; GDSC2 6.8019 26.1283 -5.327 25.8234
EW-13 GDSC1; GDSC2 7.1158 20.5255 -2.36 17.9115
SJSA-1 GDSC1; GDSC2; CTRP2 7.4717 16.0398 0.6415 10.0342
SW1353 CTRP2 7.9625 16.5639 2.2849 12.12
Hs 888.T CTRP2 11.6713 27.6117 -0.4873 15.5725
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 219 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -3.5168 -0.4391 -3.5198 63.5191
MEC1 CTRP2 2.546 8.8262 1.224 27.879
JM1 GDSC1; GDSC2; CTRP2 -4.6494 6.556 -5.7697 63.0523
CMK CTRP2 -9.3784 27.8019 -19.3612 61.3136
MOLT-3 CTRP2 -5.9884 8.2979 -7.7653 65.2534
KO52 CTRP2 -5.3649 10.3122 -7.7869 62.3085
Peer CTRP2 -5.2522 -3.8125 -5.2522 75.2446
NB4 GDSC1; GDSC2 -5.1634 -3.7006 -5.1634 84.4584
KMS-26 CTRP2 -5.1554 -4.4286 -5.1554 74.6145
CRO-AP2 GDSC2 -5.1162 1.9191 -5.5453 71.3871
ATN-1 GDSC1; GDSC2 -5.1151 1.3831 -5.438 64.2245
P32/ISH GDSC1; GDSC2 -5.0472 -3.5614 -5.0472 68.0969
OCI-Ly7 GDSC2 -5.0303 2.296 -5.5348 70.3726
Mino CTRP2 -5.0215 -3.2363 -5.0215 73.6803
A4/Fukuda GDSC2; CTRP2 -4.984 -0.792 -4.9958 72.0258
RS4;11 GDSC1; GDSC2; CTRP2 -4.7944 -1.9865 -4.7968 67.6854
SUP-M2 GDSC1; GDSC2; CTRP2 -4.7148 -1.7823 -4.7157 71.3219
SR GDSC1; GDSC2; CTRP2 -4.6748 0.04 -4.7037 69.6945
BV-173 GDSC1; GDSC2; CTRP2 -4.6544 -2.0895 -4.6547 71.0868
ALL-PO GDSC1; GDSC2 -4.571 -0.1617 -4.6481 62.8217
KMS-21-BM CTRP2 -4.4414 3.0342 -4.74 65.5546
QIMR-WIL GDSC1; GDSC2 -4.4261 0.3302 -4.5437 71.6817
MOLT-16 GDSC1; GDSC2; CTRP2 -4.4038 -2.566 -4.4038 69.5838
DoHH2 GDSC1; GDSC2 -4.3971 -2.1957 -4.398 62.7415
697 GDSC1; GDSC2; CTRP2 -4.2925 -2.2818 -4.2925 68.8291
IM-9 GDSC1; GDSC2 -4.2118 -1.0307 -4.2276 60.9457
Karpas-231 GDSC1; GDSC2 -4.1263 -2.1879 -4.1267 60.591
P12-Ichikawa GDSC1; GDSC2; CTRP2 -3.9599 -0.981 -3.9616 66.4332
SUP-B8 GDSC2 -3.9564 -2.0022 -3.9569 72.6167
NALM-6 GDSC1; GDSC2; CTRP2 -3.9505 -0.8201 -3.953 66.3191
SU-DHL-16 GDSC1; GDSC2 -3.8923 0.142 -3.9631 69.0329
MOLM-16 GDSC2; CTRP2 -3.8149 1.4429 -3.8914 64.1886
KOPN-8 GDSC1; GDSC2 -3.8006 1.3606 -4.0168 56.8565
RCH-ACV GDSC1; GDSC2; CTRP2 -3.7052 -0.9561 -3.7063 64.8334
HPB-ALL CTRP2 -3.6871 -1.8817 -3.6871 64.8237
NU-DHL-1 CTRP2 -3.6786 0.7462 -3.7106 63.945
SEM CTRP2 -3.6746 -1.4948 -3.6747 64.7176
ML-2 GDSC1; GDSC2 -3.6201 -0.1668 -3.6576 56.2332
MC116 GDSC1; GDSC2; CTRP2 -3.5836 -1.2543 -3.5838 64.0999
SIG-M5 GDSC1; GDSC2; CTRP2 -3.5725 -2.026 -3.5725 64.0673
Kasumi-2 CTRP2 -3.561 2.2156 -3.6938 62.3309
MV4-11 GDSC1; GDSC2; CTRP2 -3.4552 1.453 -3.5179 62.2859
NU-DUL-1 GDSC1; GDSC2; CTRP2 -3.3956 0.1804 -3.4054 62.575
P30/OHK GDSC1; GDSC2 -3.3821 0.3002 -3.4423 54.3303
HAL-01 GDSC1; GDSC2 -3.3683 1.2594 -3.5371 53.9887
DEL GDSC1; GDSC2; CTRP2 -3.3529 2.5872 -3.5152 61.027
BC-3 GDSC1; GDSC2 -3.3188 3.0811 -3.8609 61.3823
OCI-Ly19 GDSC1; GDSC2; CTRP2 -3.1949 0.3599 -3.2056 61.2888
OCI-Ly3 CTRP2 -3.1127 14.4021 -7.0271 54.8155
CCRF-CEM GDSC1; GDSC2 -3.1108 0.7764 -3.2016 52.2116
MOLM-6 CTRP2 -2.9588 3.754 -3.2639 58.3556
BONNA-12 GDSC2 -2.8885 1.6872 -3.0896 60.1674
CESS GDSC1; GDSC2 -2.8786 4.6747 -3.8573 50.331
SUP-B15 GDSC1; GDSC2; CTRP2 -2.7712 6.5509 -3.7193 56.1626
ST486 GDSC1; GDSC2; CTRP2 -2.7383 2.3723 -2.8425 57.8323
MOLM-13 GDSC1; GDSC2; CTRP2 -2.7371 3.4374 -2.9738 57.3717
KE-37 GDSC1; GDSC2; CTRP2 -2.7156 2.3724 -2.8187 57.7031
BE-13 GDSC1; GDSC2 -2.7092 4.1187 -3.4936 49.3078
GA-10 GDSC1; GDSC2; CTRP2 -2.7087 0.7367 -2.7205 58.1622
VAL GDSC1; GDSC2 -2.6894 6.2937 -4.2357 49.3162
SU-DHL-5 GDSC1; GDSC2 -2.5972 5.5662 -3.8646 48.7607
LC4-1 GDSC1; GDSC2 -2.5695 3.9347 -3.2847 48.4063
Ku812 GDSC1; GDSC2; CTRP2 -2.4929 3.218 -2.6806 56.1347
Karpas-45 GDSC1; GDSC2 -2.2123 3.769 -2.8455 45.987
CML-T1 GDSC1; GDSC2; CTRP2 -2.1744 3.9563 -2.4533 54.1446
Reh GDSC1; GDSC2 -2.1541 2.2205 -2.3935 45.0503
ALL-SIL GDSC1; GDSC2; CTRP2 -2.1002 3.5636 -2.3102 53.8169
OCI-AML-2 GDSC1; GDSC2 -2.0677 3.4737 -2.6021 44.8635
EoL-1 GDSC1; GDSC2; CTRP2 -1.9902 1.898 -2.0276 53.4263
BC-1 GDSC1; GDSC2 -1.975 3.6288 -2.5454 44.2631
TALL-1 [Human adult T-ALL] GDSC2; CTRP2 -1.8705 4.8351 -2.2958 52.299
PF-382 GDSC1; GDSC2; CTRP2 -1.8406 5.886 -2.518 51.9948
NCO2 CTRP2 -1.7852 0.5818 -1.7867 52.1579
Loucy GDSC1; GDSC2 -1.7598 5.7891 -3.0498 43.8596
Kasumi-1 GDSC2; CTRP2 -1.7365 3.1513 -1.8672 51.7152
OCI-AML-5 GDSC1; GDSC2; CTRP2 -1.6263 1.5727 -1.6413 51.0909
MOLT-4 GDSC1; GDSC2 -1.619 4.2718 -2.3566 42.0547
GDM-1 GDSC1; GDSC2; CTRP2 -1.5958 6.2896 -2.3618 50.7022
MY-M12 GDSC1; GDSC2 -1.5257 4.9637 -2.4928 49.0665
NKM-1 GDSC1; GDSC2 -1.4865 4.4843 -2.2835 48.7322
RPMI-8866 GDSC1; GDSC2 -1.4283 5.092 -2.4342 41.2656
AMO1 GDSC1; GDSC2; CTRP2 -1.3118 3.5237 -1.4621 49.0713
EM-2 GDSC1; GDSC2; CTRP2 -1.3077 7.4813 -2.413 49.2517
JSC-1 GDSC1; GDSC2 -1.2989 10.7213 -4.6921 43.7212
MOLT-13 GDSC1; GDSC2 -1.2477 10.6534 -4.6098 43.46
SU-DHL-6 GDSC1; GDSC2; CTRP2 -1.063 7.3797 -2.1139 48.0093
CTB-1 GDSC1; GDSC2 -0.9768 7.9802 -3.1321 46.2651
CTV-1 GDSC1; GDSC2 -0.9708 4.3951 -1.6944 37.3603
KMS-11 GDSC1; GDSC2; CTRP2 -0.8815 4.0867 -1.0836 46.4134
HuT 78 CTRP2 -0.8725 8.4896 -2.2893 47.2325
RPMI-8402 GDSC1; GDSC2; CTRP2 -0.8458 8.9908 -2.4444 47.1966
JeKo-1 GDSC2; CTRP2 -0.8028 168.0475 -80.7316 49.7861
H9 GDSC1; GDSC2 -0.7997 6.495 -2.314 38.1871
MJ CTRP2 -0.7804 18.7479 -6.615 48.1934
SUP-T1 GDSC1; GDSC2; CTRP2 -0.6904 9.992 -2.6633 46.6785
JVM-3 GDSC1; GDSC2; CTRP2 -0.6695 6.6078 -1.444 45.7268
MEG-01 GDSC1; GDSC2 -0.5721 8.8159 -3.0929 38.8779
KE-97 CTRP2 -0.5669 10.5031 -2.7372 46.2422
KMS-27 CTRP2 -0.5554 18.7229 -6.3818 47.5689
JURL-MK1 GDSC1; GDSC2; CTRP2 -0.4959 3.3129 -0.5738 43.7477
RPMI-6666 GDSC1; GDSC2; CTRP2 -0.419 7.681 -1.5155 44.6774
SKM-1 GDSC1; GDSC2; CTRP2 -0.4043 4.2721 -0.6007 43.3797
HL-60 GDSC1; GDSC2; CTRP2 -0.3503 6.1607 -0.9664 43.7115
SUP-T11 CTRP2 -0.3058 7.7226 -1.4071 44.0744
Ki-JK CTRP2 -0.2825 11.6304 -2.9069 45.3075
Ri-1 CTRP2 -0.233 8.0845 -1.4547 43.8238
BL-70 CTRP2 -0.222 4.9247 -0.5244 42.4186
BALL-1 GDSC1; GDSC2 -0.1198 10.1482 -3.2588 37.5536
LAMA-84 GDSC1; GDSC2; CTRP2 -0.1 6.5425 -0.8035 42.3694
L-540 GDSC1; GDSC2; CTRP2 0.0926 6.9584 -0.7218 41.4247
Namalwa GDSC2; CTRP2 0.0979 12.2283 -2.77 43.8861
SU-DHL-8 GDSC1; GDSC2; CTRP2 0.1342 5.5897 -0.2874 40.4204
MOTN-1 CTRP2 0.1363 10.7478 -2.0987 43.1102
M-07e CTRP2 0.2629 9.1846 -1.3333 41.701
SU-DHL-10 GDSC1; GDSC2; CTRP2 0.2977 8.5515 -1.0542 41.1516
Pfeiffer CTRP2 0.35 4.4769 0.1771 38.4386
MHH-CALL-2 GDSC2 0.3686 9.4756 -2.4643 34.1228
KY821 GDSC1; GDSC2 0.4058 6.2878 -0.9716 29.4039
OCI-M1 GDSC1; GDSC2; CTRP2 0.4281 9.4002 -1.2424 40.9484
NK-92MI GDSC1; GDSC2 0.4636 18.2981 -6.6638 43.687
OPM-2 GDSC1; GDSC2; CTRP2 0.4908 7.9027 -0.6092 39.6381
JVM-2 GDSC1; GDSC2; CTRP2 0.6719 6.9776 -0.0978 37.8738
Daudi GDSC1; GDSC2; CTRP2 0.6762 6.0342 0.1887 37.1597
KG-1 GDSC1; GDSC2 0.6876 7.3098 -1.1412 29.0167
TK [Human B-cell lymphoma] GDSC1; GDSC2 0.7251 8.7046 -1.7526 30.9223
WIL2 NS GDSC1; GDSC2 0.9286 13.3812 -3.8191 35.3119
Hs 611.T CTRP2 0.9482 8.9325 -0.5057 37.744
SCC-3 GDSC1; GDSC2 0.9925 7.2819 -0.8241 26.7966
NOMO-1 GDSC1; GDSC2; CTRP2 0.9947 7.4271 0.1023 36.2011
Sc-1 GDSC1 1.0236 12.9369 -4.7136 34.338
ME1 CTRP2 1.0805 5.7811 0.6967 34.2762
OCI-AML-3 GDSC1; GDSC2; CTRP2 1.1147 6.9585 0.3897 35.0259
P31/FUJ GDSC1; GDSC2; CTRP2 1.1492 7.2 0.3471 35.018
HH [Human lymphoma] GDSC1; GDSC2; CTRP2 1.1847 11.6198 -1.3877 38.5629
KYO-1 CTRP2 1.2246 5.119 1.0051 32.8261
Farage GDSC1; GDSC2 1.2272 2.7033 1.1703 17.2849
RPMI-8226 GDSC1; GDSC2; CTRP2 1.2506 10.1052 -0.6653 37.0229
KMS-28BM CTRP2 1.3007 7.0977 0.5458 33.9416
ARH-77 GDSC1; GDSC2 1.306 5.5563 0.2735 21.0853
CA46 GDSC1; GDSC2; CTRP2 1.3278 8.6502 0.0085 35.2603
MHH-CALL-4 GDSC2; CTRP2 1.3405 13.4147 -2.0392 39.0796
HuNS1 CTRP2 1.499 9.4616 -0.137 35.0327
Jiyoye GDSC1; GDSC2 1.5042 9.307 -1.2938 26.8895
WSU-NHL GDSC1; GDSC2 1.5406 3.9081 1.1913 16.0337
THP-1 GDSC1; GDSC2 1.5446 14.4825 -3.8009 37.4087
MHH-CALL-3 CTRP2 1.65 17.4297 -3.6257 40.1783
SU-DHL-4 GDSC1; GDSC2; CTRP2 1.6742 7.316 0.8759 31.7109
Ramos.2G6.4C10 GDSC1; GDSC2 1.883 9.9608 -1.2616 25.6393
Granta-519 GDSC1; GDSC2; CTRP2 1.919 12.4127 -1.0013 35.5749
WSU-DLCL2 GDSC1; GDSC2; CTRP2 1.9471 3.3864 1.9446 27.3052
EB1 CTRP2 2.0436 7.6234 1.1642 29.6156
KMOE-2 GDSC1; GDSC2 2.3484 12.4025 -2.0532 26.9688
HC-1 GDSC1; GDSC2 2.4169 14.0602 -2.8189 28.9724
K-562 GDSC1; GDSC2; CTRP2 2.57 6.3371 2.1688 24.5477
KM-H2 GDSC1; GDSC2; CTRP2 2.7082 11.135 0.3738 29.9781
Mono-Mac-1 CTRP2 3.0377 10.4414 1.021 27.1114
SUP-HD1 GDSC1; GDSC2; CTRP2 3.0926 13.4093 -0.3158 30.7247
VL51 GDSC1; GDSC2 3.2194 13.12 -1.6628 23.4631
Karpas-422 GDSC1; GDSC2; CTRP2 3.2605 10.9214 1.0225 26.4912
MOLP-8 GDSC1; GDSC2; CTRP2 3.2771 29.6704 -8.1472 40.5592
KMS-12-BM GDSC1; GDSC2 3.2817 10.8728 -0.4871 18.8539
JJN-3 GDSC1; GDSC2; CTRP2 3.2907 14.2363 -0.5241 30.7088
DB GDSC1; GDSC2; CTRP2 3.3021 15.1422 -0.9523 31.6614
EB2 GDSC1; GDSC2 3.3043 9.8725 0.0319 16.5375
GR-ST GDSC1; GDSC2 3.341 13.1351 -1.5687 22.8437
BL-41 GDSC1; GDSC2; CTRP2 3.4138 15.6041 -1.0725 31.6417
SU-DHL-1 GDSC1; GDSC2; CTRP2 3.4163 4.7571 3.4 17.5634
YT GDSC1; GDSC2 3.4939 4.9389 2.6519 3.7677
MN-60 GDSC1; GDSC2 3.5793 11.859 -0.7341 19.1488
Mono-Mac-6 GDSC1; GDSC2; CTRP2 3.6009 16.7844 -1.4769 32.0279
KMS-20 CTRP2 3.9335 14.9094 -0.2504 28.4112
PL21 CTRP2 3.984 9.0703 2.5961 18.9754
ME1 GDSC1; GDSC2 4.0499 9.2169 0.957 10.4566
U-937 CTRP2 4.0824 6.4775 3.771 14.1821
RC-K8 GDSC1; GDSC2 4.1528 9.348 0.9702 10.1783
DND-41 GDSC1; GDSC2; CTRP2 4.3205 18.6274 -1.7357 30.8891
MLMA GDSC1; GDSC2 4.4359 14.4001 -1.3184 19.454
KMS-18 CTRP2 4.5241 9.5304 2.9151 16.3745
L-363 GDSC1; GDSC2; CTRP2 4.5674 12.5591 1.4869 21.6322
HT GDSC1; GDSC2; CTRP2 4.8631 11.3409 2.3571 17.7611
EHEB GDSC1; CTRP2 4.9793 15.4166 0.4435 24.0451
DG-75 GDSC1; GDSC2 5.0087 15.5535 -1.4513 18.7412
Ci-1 CTRP2 5.0732 7.1209 4.5757 8.3459
PL-21 GDSC1; GDSC2 5.1296 21.5967 -4.3562 29.4013
A3/Kawakami GDSC1; GDSC2; CTRP2 5.1455 13.0327 1.7755 19.2931
SK-MM-2 GDSC1; GDSC2; CTRP2 5.1677 20.3585 -1.8558 29.3311
MHH-PREB-1 GDSC1; GDSC2 5.2074 12.4484 0.2186 11.6398
TF-1 CTRP2 5.6357 13.3291 2.0561 17.2125
L-1236 GDSC1; GDSC2 5.672 16.7504 -1.5487 17.7933
U-698-M GDSC1; GDSC2 5.7126 23.1333 -4.6687 26.3168
TUR GDSC1; GDSC2 5.8634 29.7626 -7.8447 31.4564
EJM GDSC1; GDSC2; CTRP2 6.2818 14.9491 1.7883 16.892
HD-MY-Z CTRP2 6.2921 15.6397 1.4516 18.058
SET-2 CTRP2 6.3834 15.8622 1.4151 18.0067
F-36P CTRP2 6.4623 19.6375 -0.4071 23.3844
L-428 GDSC1; GDSC2; CTRP2 6.5919 17.0283 1.0018 18.9884
Karpas-1106P GDSC2 6.676 21.1499 -2.9749 20.4607
Hs 445 GDSC1; GDSC2 6.6786 22.7862 -3.7742 22.5717
REC-1 CTRP2 6.7228 9.421 4.8826 3.7191
Toledo CTRP2 6.9446 18.8024 0.3992 20.2099
OCI-Ly10 CTRP2 7.0079 15.5974 2.0452 14.6063
ROS-50 GDSC1; GDSC2 7.1843 20.0717 -2.0936 19.2285
MOLP-2 CTRP2 7.242 18.6739 0.6978 18.7609
Karpas-620 GDSC1; GDSC2; CTRP2 7.2957 16.7403 1.7001 15.3392
HEL 92.1.7 CTRP2 7.6578 24.4872 -1.8693 24.7628
HDLM-2 GDSC1; GDSC2; CTRP2 8.0551 16.0711 2.5919 10.8328
AML-193 CTRP2 8.2277 24.6701 -1.5173 23.0379
P3HR-1 CTRP2 8.2548 20.7767 0.4295 17.8573
KMM-1 CTRP2 8.7157 10.8887 5.3262 0.4281
KCL-22 GDSC1; GDSC2; CTRP2 8.796 24.4537 -0.9798 20.8484
U266B1 GDSC1; GDSC2; CTRP2 8.8605 25.3161 -1.3571 21.665
HEL GDSC1; GDSC2; CTRP2 8.9743 21.1957 0.75 15.752
LP-1 GDSC1; GDSC2; CTRP2 9.0394 20.3661 1.2 14.2286
Raji GDSC1; GDSC2; CTRP2 9.1433 20.1255 1.3893 13.456
MM1.S GDSC2; CTRP2 9.3366 22.687 0.2817 16.6158
NCI-H929 GDSC2; CTRP2 9.88 23.3165 0.3583 15.6066
RL GDSC1; GDSC2; CTRP2 10.0924 26.2187 -0.9006 18.7298
Jurkat GDSC1; GDSC2; CTRP2 10.1272 31.6992 -3.5598 24.3973
Karpas-299 GDSC1; GDSC2; CTRP2 10.7472 23.1565 1.0185 12.456
⏷ Show the Full List of 219 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 2.6578 5.9553 1.7997 14.6984
TE15 CTRP2 3.8363 16.0011 -0.8757 30.1674
EC-GI-10 GDSC1; GDSC2; CTRP2 1.9694 13.807 -1.5973 36.5306
TE-11 GDSC1; GDSC2; CTRP2 3.1359 10.188 1.2349 26.1465
KYSE-410 GDSC1; GDSC2; CTRP2 3.1857 8.3873 2.0762 23.0772
TE-6 GDSC2; CTRP2 3.9165 11.4726 0.2515 18.3095
KYSE-140 GDSC1; GDSC2; CTRP2 3.9562 13.5131 0.4533 26.4201
KYSE-520 GDSC1; GDSC2; CTRP2 4.2569 13.1388 0.916 24.2706
KYSE-150 GDSC1; GDSC2; CTRP2 4.4222 12.5848 1.3403 22.4796
OE21 GDSC1; GDSC2; CTRP2 4.4314 14.7284 0.2944 25.7331
TE-8 GDSC1; GDSC2 4.5926 19.2301 -3.5997 25.9988
KYSE-30 CTRP2 4.6163 10.2567 2.6554 17.1784
TE-15 GDSC1; GDSC2 4.679 15.6367 -1.7443 20.4359
KYSE-510 GDSC1; GDSC2; CTRP2 4.8902 10.5456 2.7719 16.0796
KYSE-270 GDSC1; GDSC2 4.8954 11.5779 0.4204 11.3151
TE-5 GDSC1; GDSC2; CTRP2 4.925 10.5846 2.7852 15.9473
TE-10 GDSC1; GDSC2; CTRP2 5.0493 13.3213 1.5466 20.3195
TE-9 GDSC1; GDSC2; CTRP2 5.0858 19.3905 -1.4434 28.633
KYSE-450 GDSC1; GDSC2; CTRP2 5.1477 14.3345 1.1303 21.5177
COLO 680N GDSC1; GDSC2; CTRP2 5.1527 10.6946 2.94 14.8163
TE-1 GDSC1; GDSC2; CTRP2 5.3497 13.064 1.9401 18.2479
T.T GDSC1; GDSC2 5.8053 18.1893 -2.1574 22.2098
TE-4 GDSC1; GDSC2; CTRP2 5.847 12.1288 2.8362 13.7643
KYSE-70 GDSC1; GDSC2; CTRP2 7.0053 18.0462 0.8243 18.7899
KYSE-180 GDSC1; GDSC2; CTRP2 8.5163 13.9679 3.9043 5.1801
OE33 GDSC1; GDSC2; CTRP2 10.1086 20.5898 1.8158 10.7126
TE-14 CTRP2 10.6041 32.6916 -3.6965 24.0042
OE19 GDSC1; GDSC2; CTRP2 11.0437 28.4315 -1.3064 18.4315
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.0383 15.7926 1.9718 14.8199
KP-4 GDSC1; GDSC2; CTRP2 0.5944 8.1867 -0.6004 39.2275
HuP-T4 GDSC1; GDSC2; CTRP2 2.44 11.8464 -0.2208 32.3114
HPAC GDSC1; GDSC2; CTRP2 3.2235 12.3527 0.3139 28.7138
BxPC-3 GDSC1; GDSC2; CTRP2 3.4475 10.9787 1.1804 25.4765
L3.3 CTRP2 3.6382 8.1014 2.6686 19.6147
Panc 08.13 GDSC1; GDSC2; CTRP2 4.2758 13.3441 0.833 24.4865
Capan-2 GDSC1; GDSC2; CTRP2 4.3661 10.7686 2.1706 19.6418
MZ-PC-1 GDSC1; GDSC2 4.5125 14.9406 -1.5275 23.0753
SW1990 GDSC1; GDSC2; CTRP2 4.536 11.2714 2.0876 19.5439
PK-59 CTRP2 4.6238 8.8062 3.3544 14.375
Panc 03.27 GDSC1; GDSC2; CTRP2 4.7126 13.823 0.9962 22.9364
DAN-G GDSC1; GDSC2; CTRP2 5.0428 12.3104 2.042 18.5452
PL4 GDSC1; GDSC2 5.062 17.8779 -2.5616 22.2466
MIA PaCa-2 GDSC1; GDSC2; CTRP2 5.1749 14.5855 1.0292 21.7893
SU.86.86 GDSC1; GDSC2; CTRP2 5.1782 13.0444 1.7987 19.1371
KP-2 GDSC2; CTRP2 5.1869 13.3251 1.6669 19.5906
KP-1N GDSC1; GDSC2 5.6728 13.7673 -0.0951 12.1583
Capan-1 GDSC1; GDSC2; CTRP2 6.1915 12.1251 3.1257 11.9219
Panc 04.03 GDSC1; GDSC2; CTRP2 6.2468 11.309 3.5788 9.959
PSN1 GDSC1; GDSC2; CTRP2 6.2958 15.9558 1.2966 18.5806
PaTu 8988s CTRP2 6.3853 13.7609 2.4664 14.1646
Panc 10.05 GDSC1; GDSC2; CTRP2 6.5693 15.7822 1.6057 16.99
SNU-410 CTRP2 7.012 10.4064 4.6077 4.4069
HuP-T3 GDSC1; GDSC2; CTRP2 7.2514 16.5927 1.7393 15.2786
HPAF-II GDSC1; GDSC2; CTRP2 7.5441 16.6336 1.9417 14.0533
PK-45H CTRP2 7.6803 13.8086 3.4267 8.171
PaTu 8988t GDSC1; GDSC2; CTRP2 7.7624 8.8986 5.6767 0.1221
SUIT-2 GDSC1; GDSC2; CTRP2 7.8361 9.2346 5.5844 0.2467
SNU-213 CTRP2 7.9257 9.3424 5.5803 0.2261
Panc 05.04 CTRP2 8.0039 9.4319 5.5782 0.2073
TCC-Pan2 CTRP2 8.0872 9.4477 5.6039 0.1495
Panc 02.03 GDSC1; GDSC2; CTRP2 8.6147 19.166 1.4827 13.9338
QGP-1 GDSC1; GDSC2; CTRP2 8.9104 26.918 -2.1108 23.2887
YAPC GDSC1; GDSC2; CTRP2 9.1567 19.1357 1.8757 11.7934
KP-3 GDSC1; GDSC2; CTRP2 9.4055 20.3249 1.4739 12.7998
Hs 766T GDSC1; GDSC2; CTRP2 9.7039 19.0548 2.2777 9.6554
CFPAC-1 GDSC1; GDSC2; CTRP2 9.9757 21.7697 1.1675 13.0037
AsPC-1 GDSC1; GDSC2; CTRP2 10.008 20.0733 1.9941 10.2408
PaTu 8902 GDSC1; GDSC2; CTRP2 13.5963 30.2825 -0.5084 13.3961
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 76 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 10.1734 27.9291 -1.6768 20.4823
A-431 GDSC1; GDSC2 -1.1124 6.9334 -2.8239 46.7465
A-388 GDSC1; GDSC2 1.9268 9.3172 -0.9053 28.5728
RPMI-7951 GDSC1; GDSC2 2.4823 11.877 -1.674 25.3911
CHL-1 GDSC1; GDSC2 2.7599 14.5183 -2.7513 27.9205
LOX-IMVI GDSC1; GDSC2; CTRP2 3.2002 10.9866 0.9325 26.9404
Hs 852.T CTRP2 3.7437 12.2793 0.8501 25.7573
IST-MEL1 GDSC1; GDSC2 3.8814 10.2184 0.3282 16.6452
WM1552C GDSC1; GDSC2 3.942 9.9779 0.4955 12.9131
G-mel GDSC1; GDSC2 4.0127 9.7005 0.6885 11.8396
DJM-1 GDSC1; GDSC2 4.0336 17.0069 -2.9369 28.6105
VMRC-MELG GDSC2 4.0955 10.693 0.2595 16.4224
HMV-II GDSC1; GDSC2 4.2015 12.7903 -0.7007 17.5959
LB2518-MEL GDSC1; GDSC2 4.2023 6.0184 2.6176 2.4564
CP66-MEL GDSC1; GDSC2 4.3536 6.9825 2.2635 3.4293
MeWo GDSC1; GDSC2; CTRP2 4.5211 8.9733 3.1751 15.3458
Hs 944.T CTRP2 4.8502 11.6185 2.2087 18.3559
451Lu GDSC1; GDSC2 4.8629 6.8426 2.6194 1.5028
Hs 934.T CTRP2 4.9397 10.1441 3.0141 14.9988
MDA-MB-435S CTRP2 4.9555 8.1384 3.9932 10.9821
MZ-MEL-7 GDSC1; GDSC2 5.1091 12.4898 0.1286 14.5717
GAK GDSC1; GDSC2 5.1866 6.7563 2.8009 0.4125
M14 GDSC1; GDSC2 5.2618 15.4369 -2.7561 14.0244
MZ-MEL-2 GDSC1; GDSC2 5.3973 15.8208 -1.2935 20.093
WM983B CTRP2 5.4795 10.8136 3.1741 13.1593
MMAc-SF GDSC1; GDSC2 5.5344 12.7845 0.2834 12.8607
COLO 679 GDSC1; GDSC2 5.5449 17.5633 -2.0417 19.6925
COLO 783 GDSC1; GDSC2 5.5802 7.2735 2.7674 0.4022
Hs 688(A).T CTRP2 5.7933 12.184 2.7629 14.1648
WM35 GDSC2 5.9042 7.7512 2.72 0.382
HT-144 GDSC1; GDSC2; CTRP2 5.9767 17.9495 0.0353 23.1225
Mel JuSo GDSC1; GDSC2; CTRP2 6.073 9.9997 4.0905 8.1551
SK-MEL-5 GDSC1; GDSC2; CTRP2 6.1434 7.2204 5.5367 1.9504
Hs 839.T CTRP2 6.3388 9.8713 4.3705 6.4873
Hs 294T CTRP2 6.3443 15.2632 1.6825 17.1487
HMCB CTRP2 6.3886 13.6218 2.5386 13.8795
IGR-37 GDSC1; GDSC2; CTRP2 6.4076 7.8923 5.4029 2.071
SK-MEL-30 GDSC1; GDSC2; CTRP2 6.5457 8.6417 5.1361 2.9521
RVH-421 GDSC1; GDSC2; CTRP2 6.6231 9.3558 4.8427 4.0379
WM278 GDSC1; GDSC2 6.6462 14.8568 0.0337 10.0043
WM115 GDSC1; GDSC2; CTRP2 6.6626 14.3491 2.3953 13.9201
Hs 940.T GDSC2; CTRP2 6.673 12.7856 3.1823 10.8038
Hs 895.T CTRP2 6.7814 10.245 4.5222 5.1082
SK-MEL-28 GDSC1; GDSC2; CTRP2 6.9213 7.8273 5.7347 0.3094
SK-MEL-2 GDSC1; GDSC2; CTRP2 7.3261 8.3624 5.7021 0.201
CP50-MEL-B GDSC1; GDSC2 7.4573 19.1076 -1.4476 16.4787
IGR-39 CTRP2 7.5409 12.5865 3.9209 6.4058
Hs 936.T CTRP2 7.6038 8.6165 5.7172 0.1025
A2058 GDSC1; GDSC2; CTRP2 7.7649 10.3031 5.1203 1.5649
K029AX CTRP2 7.8691 9.7062 5.419 0.5952
CJM [Human melanoma] CTRP2 7.9077 24.1702 -1.5163 23.5583
WM88 CTRP2 7.9231 22.2502 -0.551 21.1598
SH-4 GDSC1; GDSC2 7.9291 18.2195 -0.7271 11.0883
COLO 741 CTRP2 8.2424 10.089 5.4317 0.3953
COLO 800 GDSC1; GDSC2; CTRP2 8.2931 19.5045 1.0841 15.7553
WM793 GDSC1; GDSC2; CTRP2 8.4289 19.4162 1.2266 15.0747
SK-MEL-31 GDSC2; CTRP2 8.4499 17.9344 1.9653 12.5182
A101D GDSC1; GDSC2; CTRP2 8.5078 9.8416 5.6184 0.0693
WM1799 CTRP2 8.6253 16.374 2.8399 9.0673
A-375 GDSC1; GDSC2; CTRP2 8.698 23.0075 -0.3401 19.3402
UACC-62 GDSC1; GDSC2; CTRP2 8.9953 15.6017 3.4439 6.3247
COLO 792 GDSC2; CTRP2 9.0017 22.7553 0.007 17.9087
IPC-298 GDSC1; GDSC2; CTRP2 9.5146 20.3562 1.5332 12.4502
LB373-MEL-D GDSC1; GDSC2 9.5195 22.1341 -1.5584 13.4999
SK-MEL-3 GDSC1; GDSC2; CTRP2 9.7121 21.1402 1.291 12.9692
Hs 938.T GDSC1; GDSC2 9.8798 24.3018 -2.3369 15.5384
G-361 GDSC1; GDSC2; CTRP2 10.305 24.5144 0.0737 15.8329
COLO 829 GDSC1; GDSC2; CTRP2 10.3918 28.8031 -1.9467 20.7883
SK-MEL-24 GDSC1; GDSC2; CTRP2 10.4153 22.1206 1.292 12.0256
WM266-4 CTRP2 10.4662 24.2505 0.3106 14.9379
IGR-1 GDSC1; GDSC2; CTRP2 10.8143 23.4554 0.9209 12.6698
UACC-257 GDSC1; GDSC2; CTRP2 10.9881 23.0818 1.209 11.5649
WT2-iPS GDSC1; GDSC2; CTRP2 11.2604 23.6323 1.1243 11.4955
SK-MEL-1 GDSC1; GDSC2; CTRP2 11.4479 24.5047 0.8351 12.1444
Mel Ho GDSC1; GDSC2; CTRP2 12.474 24.8396 1.3105 9.5603
EquiPSC Line K2 GDSC2 5.9556 18.3771 -2.1395 21.8318
⏷ Show the Full List of 76 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1; GDSC2 0.05 5.413 -0.9775 30.7592
KYSE-50 GDSC1; GDSC2 1.8754 10.5105 -1.5391 26.6295
TE-12 GDSC1; GDSC2 1.996 10.4662 -1.4076 25.8286
OACM5.1 C GDSC1; GDSC2 2.824 12.9962 -1.9362 25.3553
KYSE-220 GDSC1; GDSC2 3.2981 13.1673 -1.6206 23.1268
ESO-51 GDSC2 4.1369 12.3718 -0.543 17.095
HCE-4 GDSC1; GDSC2 4.5644 15.2491 -1.6405 23.3455
FLO-1 GDSC1; GDSC2 4.6916 17.054 -2.4387 22.6311
KYAE-1 GDSC1; GDSC2 6.0492 7.614 2.8206 0.1246
SK-GT-4 GDSC1; GDSC2 6.0538 15.9483 -0.8849 14.6655
ESO-26 GDSC1; GDSC2 8.7165 23.4879 -2.6974 16.4557
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2; CTRP2 6.4711 19.729 -0.4457 23.4695
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 -7.0156 -6.1732 -7.0156 86.9919
SJNB-14 GDSC1; GDSC2 -6.1585 4.8677 -7.4843 64.4438
MHH-NB-11 GDSC1; GDSC2; CTRP2 -5.6073 -3.2971 -5.6073 77.3439
IMR-5 GDSC1; GDSC2 -5.3242 -1.706 -5.3414 69.0447
SK-N-SH GDSC1; GDSC2; CTRP2 -5.3096 15.5106 -9.7836 59.5427
NH-12 GDSC1; GDSC2 -5.1395 16.3023 -11.0918 55.7251
CHP-212 GDSC1; GDSC2; CTRP2 -4.5681 2.9858 -4.8684 66.1011
NB69 GDSC1; GDSC2 -4.5477 4.2535 -5.5378 58.9816
KP-N-YS GDSC1; GDSC2 -3.8119 -1.0885 -3.8197 70.4164
NH-6 CTRP2 -3.8096 9.3677 -5.7706 58.6104
SJNB-6 GDSC1; GDSC2 -3.7643 4.1987 -4.6676 62.3624
SJNB-10 GDSC1; GDSC2 -3.4951 3.5419 -4.179 54.0714
CHP-134 GDSC1; GDSC2 -3.2986 4.0576 -4.6516 46.831
Kelly GDSC1; GDSC2; CTRP2 -2.9216 1.1578 -2.9511 59.3633
SiMa GDSC1; GDSC2; CTRP2 -2.9118 4.626 -3.3822 57.6755
CHP-126 GDSC2; CTRP2 -2.9103 5.0299 -3.471 57.4668
TGW GDSC1; GDSC2 -2.6443 6.8833 -4.4176 49.1207
SK-N-MC-IXC GDSC1; GDSC2 -2.5394 3.7582 -3.199 56.1548
SK-N-DZ GDSC1; GDSC2; CTRP2 -2.3379 3.7487 -2.5944 55.1042
SK-N-BE(2) CTRP2 -1.5071 10.5424 -3.7477 50.1837
SJNB-12 GDSC1; GDSC2 -1.4105 7.3477 -3.309 48.6062
SJNB-13 GDSC1; GDSC2 -0.7508 7.3921 -2.6434 38.7011
SJNB-5 GDSC1; GDSC2 -0.199 13.6639 -5.0128 44.5116
NB(TU)1 GDSC1; GDSC2 0.0719 9.7551 -3.9564 31.102
KP-N-SI9s CTRP2 0.0907 7.5553 -0.9205 41.7607
SJNB-7 GDSC1; GDSC2 0.7773 7.4079 -1.0965 28.5458
GOTO GDSC1; GDSC2 1.0227 16.0933 -5.0683 37.1324
NB1 GDSC1; GDSC2; CTRP2 1.2621 10.3743 -0.7674 37.1883
SK-N-FI GDSC1; GDSC2; CTRP2 1.5652 14.2415 -2.1986 38.6451
SK-N-BE(2)-M17 GDSC1; GDSC2 2.0974 12.4699 -2.3087 28.4143
SK-N-AS GDSC1; GDSC2; CTRP2 2.6728 13.9266 -0.9675 33.3516
SJNB-17 GDSC1; GDSC2 2.9358 10.6379 -0.6626 24.1549
KP-N-RT-BM-1 GDSC2 2.9785 19.6832 -5.1467 35.6675
LA-N-6 GDSC1; GDSC2 4.9103 14.7711 -1.1389 20.6401
KP-N-YN GDSC1; GDSC2; CTRP2 6.2311 20.133 -0.8449 24.9463
GI-ME-N GDSC1; GDSC2 7.0167 25.7846 -4.9987 24.809
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 1.4236 5.3091 1.1817 31.5848
HuH-28 CTRP2 2.6521 5.2345 2.5277 23.0249
SNU-478 CTRP2 3.5164 12.6205 0.4688 27.4947
HuCC-T1 GDSC1; GDSC2 3.7354 12.527 -0.9407 19.5985
SNU-1196 CTRP2 4.8917 8.3391 3.8364 11.7733
SNU-308 CTRP2 6.7953 15.3973 1.978 15.2358
SNU-869 CTRP2 7.9975 17.8067 1.7009 14.1577
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1187 GDSC1; GDSC2 -4.1279 15.5587 -9.74 53.503
MDA-MB-468 GDSC1; GDSC2; CTRP2 -2.5426 3.3953 -2.7591 56.3449
HCC2157 GDSC1; GDSC2 -0.6276 8.8538 -3.166 39.2208
MFM-223 GDSC1; GDSC2 -0.5139 5.4825 -1.6031 35.1087
OCUB-M GDSC1; GDSC2 0.7212 12.8265 -3.7403 35.7706
DU4475 GDSC1; GDSC2; CTRP2 1.1209 10.9534 -1.1621 38.3894
CAL-148 GDSC1; GDSC2 2.1558 12.1892 -2.1175 31.691
MDA-MB-157 GDSC1; GDSC2; CTRP2 2.4556 9.3234 0.92 29.1142
CAL-51 GDSC1; GDSC2; CTRP2 3.1697 13.4969 -0.2836 30.4392
UACC-812 GDSC1 3.35 16.8606 -4.8036 28.0092
Evsa-T GDSC1; GDSC2 3.3521 9.9952 0.0104 16.5188
COLO 824 GDSC1; GDSC2 4.0936 18.8011 -3.7844 27.4709
BT-549 GDSC1; GDSC2; CTRP2 4.1695 15.4052 -0.2776 27.9131
MDA-MB-415 GDSC1; GDSC2 4.3159 8.7949 1.3631 7.9187
AU565 GDSC1; GDSC2; CTRP2 4.3306 13.641 0.7378 24.6511
BT-20 GDSC1; GDSC2; CTRP2 4.5055 13.2491 1.091 23.1117
MRK-nu-1 GDSC1; GDSC2 4.5775 24.6091 -6.2943 31.3544
MDA-MB-436 GDSC1; GDSC2 4.6165 7.7444 2.074 3.9203
UACC-893 GDSC1; GDSC2 4.716 7.3393 2.3217 3.2332
Hs 578Bst CTRP2 4.7224 8.956 3.38 14.0319
MDA-MB-231 GDSC1; GDSC2; CTRP2 4.9313 10.1338 3.0114 15.0289
HCC1569 GDSC1; GDSC2 4.9586 17.5681 -2.4873 22.2323
HCC1599 GDSC1; GDSC2 5.1957 13.9242 -0.5103 17.3104
HDQ-P1 GDSC1; GDSC2; CTRP2 5.4358 14.1898 1.4541 19.7974
HCC202 GDSC1 5.6034 17.8323 -3.6678 19.3159
EFM-192A GDSC1; GDSC2; CTRP2 5.6535 9.087 4.1862 8.5986
HCC1937 GDSC1; GDSC2; CTRP2 5.674 12.0047 2.7502 14.4595
JIMT-1 GDSC2; CTRP2 5.7246 8.8843 4.3499 7.7646
ZR-75-30 GDSC1; GDSC2; CTRP2 6.232 11.7705 3.3361 10.9865
HCC1419 GDSC1; GDSC2; CTRP2 6.281 8.2102 5.1518 3.3193
YMB-1-E GDSC1; GDSC2 6.7848 14.6481 0.2189 10.7327
HCC1143 GDSC2; CTRP2 6.9547 18.9678 0.3248 20.4128
CAL-120 GDSC1; GDSC2; CTRP2 6.9677 14.1949 2.7107 12.157
EFM-19 GDSC1; GDSC2 7.0075 21.6547 -2.9841 19.9266
KPL-1 CTRP2 7.2435 8.1206 5.7579 0.1287
HCC38 GDSC1; GDSC2; CTRP2 7.269 17.3143 1.3946 16.4435
HCC70 GDSC1; GDSC2 7.4292 18.998 -1.4141 14.3057
ZR-75-1 CTRP2 7.5112 8.6165 5.6823 0.1768
HCC2218 GDSC1; GDSC2; CTRP2 7.5228 15.3429 2.5624 11.7887
HCC1954 GDSC1; GDSC2; CTRP2 7.742 23.5141 -1.3192 23.3762
SK-BR-3 CTRP2 8.1576 20.3803 0.5524 17.645
BT-474 GDSC1; GDSC2; CTRP2 8.1692 22.3646 -0.4197 20.4037
HCC1806 GDSC1; GDSC2; CTRP2 8.4283 15.9851 2.893 9.145
HCC1428 GDSC1; GDSC2; CTRP2 8.6954 17.5902 2.3036 10.9422
MCF-7 GDSC1; GDSC2; CTRP2 8.7026 19.358 1.4518 13.9036
MDA-MB-453 GDSC1; GDSC2; CTRP2 8.9431 21.6269 0.517 16.5103
Hs 578T GDSC1; GDSC2; CTRP2 9.0033 27.9367 -2.5443 24.0533
MDA-MB-330 GDSC1; GDSC2 9.0255 22.2172 -1.9009 13.5938
HMC-1-8 CTRP2 9.1015 18.6573 2.0679 11.2024
MDA-MB-175-VII GDSC1; GDSC2 9.2553 21.704 -1.5211 13.7358
BT-483 GDSC1; GDSC2 9.5308 23.6051 -2.2305 15.6935
CAL-85-1 GDSC1; GDSC2; CTRP2 9.6158 20.3232 1.6173 12.0303
T-47D GDSC1; GDSC2; CTRP2 9.6406 25.4382 -0.8433 19.2327
HCC1395 GDSC1; GDSC2; CTRP2 9.7372 24.8101 -0.4673 18.1155
MDA-MB-361 GDSC1; GDSC2; CTRP2 10.0138 25.4438 -0.5793 18.0155
HCC1500 GDSC1; GDSC2; CTRP2 10.3499 22.9373 0.8606 13.4578
CAMA-1 GDSC1; GDSC2; CTRP2 12.9528 29.7579 -0.6682 14.5136
BT 428 CTRP2 1.1946 17.2323 -3.9702 41.701
BT 416 CTRP2 1.6138 10.5057 -0.4597 35.3941
BT 286 CTRP2 3.357 16.0212 -1.329 32.3229
BT 440 CTRP2 3.5936 6.674 3.1747 17.8255
BT147 CTRP2 3.6939 19.3955 -2.6787 33.9928
BT 145 CTRP2 3.7163 21.3912 -3.6462 35.3924
BT 159 CTRP2 3.9932 9.3542 2.4754 19.4151
BT 112 CTRP2 4.001 50.5821 -17.9494 43.6598
BT 231 CTRP2 4.4022 20.8684 -2.777 32.6229
BT 172 CTRP2 4.7305 20.3741 -2.2428 30.9894
BT 228 CTRP2 4.8496 13.8974 1.0826 22.3416
BT 482 CTRP2 5.5967 20.4848 -1.5521 27.8278
BT 179 CTRP2 5.65 10.1314 3.6636 10.7851
BT 216 CTRP2 5.8465 9.87 3.9643 9.1292
BT 139 CTRP2 5.8501 14.6599 1.5737 18.515
BT 245 CTRP2 6.2039 15.1426 1.6275 17.6166
BT 271 CTRP2 6.3275 25.7679 -3.5825 30.2883
BT 444 CTRP2 6.3808 10.1978 4.241 6.9539
BT 422 CTRP2 6.4547 9.4216 4.6843 4.9722
BT164 CTRP2 6.614 20.8876 -0.908 24.3782
BT 224 CTRP2 6.6301 15.6052 1.7429 16.3901
BT 320 CTRP2 6.6699 7.9878 5.5313 1.2064
BT 504 CTRP2 6.7359 21.3537 -1.0419 24.4798
BT 248 CTRP2 7.0096 15.4858 2.102 14.3939
BT 239 CTRP2 7.1819 32.923 -6.4591 32.8616
BT 328 CTRP2 7.8054 14.8578 3.0051 9.6357
BT 187 CTRP2 7.8863 22.8204 -0.8623 22.0217
BT 131 CTRP2 8.1356 23.2109 -0.8644 21.6141
BT 330 CTRP2 8.1629 32.4505 -5.4373 30.1456
BT 498 CTRP2 8.2101 18.5287 1.5022 14.4998
BT 232 CTRP2 10.3587 22.9767 0.8476 13.4859
BT 333 CTRP2 11.6554 27.0804 -0.2454 14.9516
BT 359 CTRP2 12.9496 35.5625 -3.4318 20.6083
BT 340 CTRP2 13.2329 28.9125 -0.0988 12.7264
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 11.1973 24.4406 0.7045 12.8394
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC1; GDSC2; CTRP2 -1.2088 10.4135 -3.3802 48.9757
H4 GDSC1; GDSC2 -0.2859 6.8981 -1.9497 35.1773
MOG-G-CCM GDSC1; GDSC2 0.0081 9.234 -2.7055 41.1683
MOG-G-UVW GDSC1; GDSC2 0.4231 12.0844 -3.6598 40.9396
D-247MG GDSC1; GDSC2 0.544 13.2958 -4.1344 41.1341
D-336MG GDSC1; GDSC2 0.5653 11.2542 -3.124 39.6054
D-245MG GDSC2 1.5467 10.0248 -1.6037 32.3834
M059J GDSC1; GDSC2 2.0707 14.0173 -3.1012 30.5947
SF539 GDSC1; GDSC2; CTRP2 2.1703 10.0294 0.3209 31.7217
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 2.3221 12.4702 -2.11 27.2136
D-566MG GDSC1; GDSC2 2.3699 11.3459 -1.5086 29.1861
SF126 GDSC1; GDSC2; CTRP2 2.375 6.6879 1.8473 26.2815
YH-13 GDSC1; GDSC2; CTRP2 3.2931 16.205 -1.4782 32.782
GB-1 GDSC1; GDSC2; CTRP2 3.4102 7.2109 2.7841 19.8138
AM-38 GDSC1; GDSC2 3.4572 18.7356 -4.2724 29.9124
SNB-75 GDSC1; GDSC2; CTRP2 3.6761 8.7516 2.4268 20.431
SW1088 GDSC1; GDSC2; CTRP2 3.8159 10.8085 1.6212 23.0146
GI-1 GDSC1; GDSC2 3.8266 13.8452 -1.5253 21.5463
D-423MG GDSC1; GDSC2 3.8391 18.1411 -3.6612 30.8327
SK-MG-1 GDSC1; GDSC2 3.8851 9.9678 0.4558 13.2259
LNZTA3WT4 GDSC1; GDSC2 4.0093 11.5652 -0.2418 19.1179
SNU-201 CTRP2 4.177 6.207 3.9599 13.2064
SNU-738 CTRP2 4.199 6.917 3.7395 13.966
D-263MG GDSC1; GDSC2 4.5058 15.3605 -1.7414 20.7912
KNS-81 CTRP2 4.5112 6.4327 3.2465 3.2156
Daoy GDSC1; GDSC2; CTRP2 4.5258 13.9486 0.7649 24.1041
Onda 11 GDSC1; GDSC2 4.5577 8.3724 1.7376 6.9284
DK-MG GDSC1; GDSC2; CTRP2 4.5622 19.7098 -2.0597 30.9979
LN-18 GDSC1; GDSC2; CTRP2 4.5999 13.5673 1.0204 23.1198
Hs 683 GDSC1; GDSC2; CTRP2 4.7357 15.4079 0.2318 25.2096
KALS-1 GDSC1; GDSC2; CTRP2 4.7376 13.7927 1.0337 22.7573
Onda 10 GDSC1; GDSC2 4.8349 6.9768 2.5481 1.879
D-502MG GDSC1; GDSC2 5.1279 18.9938 -3.0646 26.3616
SF268 GDSC1; GDSC2; CTRP2 5.1396 15.4815 0.5521 23.3657
8-MG-BA GDSC1; GDSC2; CTRP2 5.1741 13.3368 1.6497 19.6795
GaMG GDSC1; GDSC2; CTRP2 5.226 11.8119 2.4531 16.5787
SNU-489 CTRP2 5.2896 8.1107 4.3303 8.8073
KNS-60 CTRP2 5.3382 13.4083 0.424 14.5514
LN-405 GDSC1; GDSC2 5.3579 14.405 -0.6281 14.9388
42-MG-BA GDSC1; GDSC2; CTRP2 5.4012 15.0181 1.0109 21.3583
KNS-81-FD GDSC1; GDSC2 5.5021 12.025 0.6258 11.1808
D-392MG GDSC1; GDSC2 5.5727 17.2863 -1.8848 19.1256
CCF-STTG1 CTRP2 5.9097 10.9557 3.4756 11.0367
ONS-76 GDSC1; GDSC2; CTRP2 5.9261 14.2878 1.8237 17.4694
U-251MG GDSC1; GDSC2; CTRP2 6.1101 14.5074 1.8675 16.9424
TM-31 CTRP2 6.1548 13.1084 2.604 14.0731
A-172 GDSC1; GDSC2; CTRP2 6.1739 15.5191 1.4145 18.4178
SF295 GDSC1; GDSC2; CTRP2 6.2792 14.5314 1.9949 16.1455
SNU-626 CTRP2 6.3243 9.9396 4.3249 6.7042
M059K CTRP2 6.4021 18.5165 0.1038 22.0931
T98G GDSC1; GDSC2; CTRP2 6.4509 14.0197 2.3902 14.3334
CAS-1 GDSC1; GDSC2; CTRP2 6.4756 17.3836 0.73 20.0775
KINGS-1 GDSC1; GDSC2 6.6156 20.6814 -2.7895 20.0362
Becker GDSC1; GDSC2; CTRP2 6.7646 15.2441 2.0301 15.1013
D-542MG GDSC1; GDSC2 6.8579 25.8197 -5.1333 27.6388
SNU-466 CTRP2 6.9858 8.3759 5.5382 0.8582
YKG-1 GDSC1; GDSC2; CTRP2 7.2482 20.255 -0.0843 21.0595
SNU-1105 CTRP2 7.2665 14.7804 2.6484 11.8857
SW1783 GDSC1; GDSC2; CTRP2 7.4834 17.9251 1.2566 16.5346
PFSK-1 GDSC1; GDSC2 7.5519 21.4766 -2.5179 17.6856
GMS-10 CTRP2 7.7204 13.1935 3.7518 6.8212
U-118MG GDSC1; GDSC2; CTRP2 7.7251 19.5722 0.6251 18.1449
DBTRG-05MG GDSC1; GDSC2; CTRP2 7.989 18.4163 1.3948 15.2204
NMC-G1 GDSC1; GDSC2; CTRP2 8.3053 17.1677 2.2358 11.7677
U-87MG ATCC GDSC1; GDSC2; CTRP2 8.3734 9.6961 5.6209 0.0829
KG-1-C CTRP2 8.5048 17.8597 2.0404 12.1684
LN-229 GDSC1; GDSC2; CTRP2 8.696 18.3674 1.9284 12.2782
GOS-3 CTRP2 9.0988 19.3593 1.7285 12.3814
KNS-42 GDSC1; GDSC2; CTRP2 10.2569 21.1598 1.6429 11.0952
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1; GDSC2 3.5439 5.176 2.5727 4.1358
TGBC24TKB GDSC1; GDSC2 3.7405 15.707 -2.5253 24.949
ETK-1 GDSC1; GDSC2 5.7209 16.5432 -1.4117 17.2181
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 -4.3783 1.1132 -4.4543 67.2281
AN3-CA GDSC1; GDSC2; CTRP2 0.1381 7.8197 -0.9606 41.6327
JHUEM-7 CTRP2 0.3422 5.3923 -0.0134 38.9548
MFE-280 GDSC1; GDSC2 2.3745 7.7193 0.2911 17.7653
JHUEM-3 CTRP2 2.9406 8.1261 1.9264 24.3156
RL95-2 GDSC1; GDSC2; CTRP2 2.9662 15.9631 -1.6668 33.9663
ESS-1 GDSC1; GDSC2; CTRP2 3.4129 9.2062 1.9567 22.8835
KLE GDSC1; GDSC2; CTRP2 3.5029 12.0317 0.7372 26.7313
JHUEM-1 CTRP2 3.5805 8.8863 2.2696 21.278
MFE-296 GDSC1; GDSC2; CTRP2 4.0046 14.1611 0.1819 27.0767
HEC-151 CTRP2 4.2894 6.9935 3.8065 13.4572
HEC-1-A CTRP2 4.6594 9.3188 3.1467 15.1234
HEC-59 CTRP2 4.6985 14.3185 0.7383 23.7854
EN GDSC1; GDSC2; CTRP2 4.7595 23.8336 -3.9424 33.7047
EFE-184 CTRP2 5.609 9.1588 4.1109 9.0072
MFE-319 GDSC1; GDSC2; CTRP2 6.2207 15.4923 1.4665 18.1463
HEC-6 CTRP2 6.7201 11.3151 3.9488 7.5796
HEC-265 CTRP2 7.3396 8.3325 5.7185 0.1667
HEC-1-B CTRP2 8.7053 20.261 1.0132 15.3355
HEC-251 CTRP2 8.8636 19.2129 1.6359 13.0402
HEC-50B CTRP2 10.3796 39.5034 -7.2239 29.4943
HEC-108 CTRP2 12.7283 27.5344 0.2273 12.4015
Ishikawa (Heraklio) 02 ER- CTRP2 6.802 9.3869 4.9546 3.3084
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB2241-RCC GDSC1; GDSC2 1.1375 5.5301 0.1115 27.3151
KTCTL-13 GDSC1; GDSC2 1.5635 10.0487 -1.5996 32.3067
UO-31 GDSC1; GDSC2; CTRP2 1.6428 7.0077 0.947 31.5967
KTCTL-26A GDSC1; GDSC2 2.0988 13.4631 -2.8009 33.6865
LB996-RCC GDSC1; GDSC2 2.2418 11.0929 -1.4967 25.4447
LB1047-RCC GDSC1; GDSC2 2.4166 8.5772 -0.0937 23.3185
TUHR14TKB CTRP2 2.4991 7.3571 1.7514 50.4841
KTCTL-1M GDSC1; GDSC2 2.6374 7.1112 0.8304 17.6702
KTCTL-140 GDSC1; GDSC2 2.7105 12.959 -2.0151 29.6995
A-704 GDSC1; GDSC2 3.4001 13.4835 -1.6939 23.1296
ACHN GDSC1; GDSC2; CTRP2 3.8379 8.6683 2.629 19.2304
NCC010 GDSC2 3.8608 12.4501 -0.8012 18.7612
Caki-1 GDSC1; GDSC2; CTRP2 4.0406 8.1567 3.0617 17.0195
OS-RC-2 GDSC1; GDSC2; CTRP2 4.1696 11.2803 1.737 21.7122
KTCTL-195 GDSC1; GDSC2 4.3943 14.2814 -1.2918 19.4462
NCC021 GDSC1; GDSC2 4.6179 16.6045 -2.2726 25.2866
CAL-54 GDSC1; GDSC2; CTRP2 4.6499 15.3929 0.1626 25.6018
VMRC-RCZ GDSC1; GDSC2; CTRP2 4.6882 12.1645 1.7918 20.2709
786-O GDSC1; GDSC2; CTRP2 4.6998 14.3477 0.725 23.8238
SN12C GDSC1; GDSC2 4.8474 14.3814 -0.9937 17.3792
Caki-2 CTRP2 4.9893 7.547 4.2999 9.6608
SW13 GDSC1; GDSC2 5.1353 15.6192 -1.3886 18.2636
KMRC-2 CTRP2 5.2982 9.1947 3.8111 10.9307
RXF 393L GDSC1; GDSC2 5.4758 16.0754 -1.361 17.4999
SW156 GDSC1; GDSC2 5.4882 15.2687 -0.9564 18.5666
VMRC-RCW GDSC1; GDSC2; CTRP2 5.5011 8.1112 4.5294 7.5006
TK-10 GDSC1; GDSC2 5.6033 13.9879 -0.2502 12.9357
TUHR10TKB CTRP2 5.6174 7.3745 4.9969 5.3031
KMRC-20 GDSC1; GDSC2; CTRP2 5.6947 12.6898 2.426 15.687
KMRC-3 CTRP2 6.1277 12.0041 3.1337 12.0119
BB65-RCC GDSC1; GDSC2 6.2621 17.5409 -1.5112 19.0271
A-498 GDSC1; GDSC2; CTRP2 6.3833 14.1797 2.2556 14.973
KTCTL-21 GDSC1; GDSC2 6.4886 22.7192 -3.8808 25.6052
HA7-RCC GDSC1; GDSC2 6.4939 14.2278 0.2315 9.411
TUHR4TKB CTRP2 6.8622 16.3825 1.5401 16.6741
KMRC-1 GDSC1; GDSC2; CTRP2 7.56 17.0674 1.7394 14.7471
BFTC-909 GDSC1; GDSC2; CTRP2 8.2276 19.7061 0.9367 16.3344
SNU-1272 CTRP2 8.5039 17.8325 2.053 12.1251
769-P GDSC1; GDSC2; CTRP2 9.5878 21.0446 1.2524 13.2673
RCC10RGB GDSC1; GDSC2; CTRP2 10.046 19.6437 2.2201 9.4211
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 GDSC1; GDSC2; CTRP2 -4.0385 5.1874 -4.7377 62.0611
GP2d CTRP2 -2.6418 11.1661 -5.1984 54.201
CL-34 CTRP2 -2.2161 3.8421 -2.4789 54.4056
COLO205 GDSC1; GDSC2; CTRP2 -2.1897 2.5305 -2.2808 54.5652
SW948 GDSC1; GDSC2; CTRP2 -2.152 1.0291 -2.162 54.5524
CL-11 GDSC1; GDSC2; CTRP2 -0.4419 8.4435 -1.8089 45.0598
NCI-H716 GDSC1; GDSC2; CTRP2 0.0449 4.445 -0.1459 40.4726
SNU-175 GDSC1; GDSC2; CTRP2 0.0774 7.2876 -0.845 41.6938
NCI-H508 GDSC2; CTRP2 1.1896 10.5244 -0.9066 37.6981
KM12 GDSC1; GDSC2; CTRP2 1.7859 13.1955 -1.4943 36.8856
HT115 GDSC1; GDSC2; CTRP2 2.0309 13.5386 -1.4112 36.0233
SNU-407 GDSC1; GDSC2; CTRP2 2.1063 13.7606 -1.441 35.8618
LS513 GDSC1; GDSC2; CTRP2 2.1393 11.6893 -0.4501 33.7413
DiFi GDSC2 2.1645 19.0376 -5.5202 35.0303
SW1463 GDSC1; GDSC2 2.4663 8.7673 -0.143 19.4888
HCT 116 GDSC1; GDSC2; CTRP2 2.6054 16.6384 -2.3346 36.0339
SK-CO-1 GDSC2; CTRP2 2.644 11.9483 -0.065 31.3347
SW620 GDSC1; GDSC2; CTRP2 2.9847 10.0561 1.1418 26.8731
SNU-1040 GDSC1; GDSC2 3.2607 13.7777 -3.3476 20.3577
SNU-1033 CTRP2 3.3287 15.7783 -1.2369 32.2029
COLO 320 CTRP2 3.3805 8.1686 2.3713 21.4447
T84 GDSC1; GDSC2; CTRP2 3.573 12.0581 0.7922 26.3787
SW1116 GDSC1; GDSC2 3.8231 9.7244 0.5282 13.0208
SNU-61 GDSC1; GDSC2; CTRP2 3.8998 9.678 2.233 20.5744
HCT 15 GDSC1; GDSC2; CTRP2 4.01 9.8532 2.2605 20.1887
SW837 GDSC1; GDSC2 4.117 12.0334 -0.3903 16.5014
CaR-1 GDSC1; GDSC2 4.1754 12.0881 -0.3718 16.2951
LS123 GDSC1; GDSC2 4.303 9.9793 0.7713 10.8347
GP5d GDSC1; GDSC2 4.3986 13.5995 -0.9495 18.1494
SNU-C1 GDSC1; GDSC2; CTRP2 4.5085 11.2201 2.0867 19.6128
HT-55 GDSC1; GDSC2; CTRP2 4.7978 7.4298 4.1576 10.7188
SW626 GDSC1; GDSC2 4.8117 14.7408 -1.1984 18.2237
NCI-H747 GDSC1; GDSC2; CTRP2 4.8524 13.5209 1.2715 21.7079
DLD-1 CTRP2 4.9195 10.4862 2.8282 15.7891
COLO 678 GDSC1; GDSC2; CTRP2 4.9472 10.3279 2.9314 15.3135
SNU-283 GDSC2 5.0148 7.538 2.4015 2.3754
SNU-C2A CTRP2 5.2414 16.5082 0.1291 24.3836
COLO 320HSR GDSC1; GDSC2 5.4623 12.3555 0.4405 10.19
CCK-81 GDSC1; GDSC2 5.598 14.7391 -0.6189 14.4519
SNU-C5 GDSC1; GDSC2; CTRP2 5.7231 15.5973 0.9976 20.7236
SW1417 GDSC1; GDSC2; CTRP2 5.8307 10.4865 3.6429 10.5016
LoVo GDSC1; GDSC2 5.8611 18.8424 -2.4373 20.3395
LS180 GDSC1; GDSC2; CTRP2 5.8652 17.6265 0.1033 23.1544
HCT 8 CTRP2 5.9067 7.8822 5.0083 4.6283
HCC2998 GDSC1; GDSC2 6.1606 16.5407 -1.0972 15.2753
OUMS-23 CTRP2 6.2969 7.948 5.294 2.6992
C2BBe1 GDSC2; CTRP2 6.3486 11.4601 3.5857 9.741
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP2 6.3803 9.7558 4.4607 6.0357
HCC-56 CTRP2 6.4603 7.9092 5.4317 1.8746
COLO201 CTRP2 6.7414 10.4856 4.3745 5.7821
SNU-C2B GDSC1; GDSC2 7.1545 20.8569 -2.4935 18.2541
LS411N GDSC1; GDSC2; CTRP2 7.2177 8.5086 5.5986 0.4982
SNU-503 CTRP2 7.3024 17.7746 1.1919 17.0656
HT-29 GDSC1; GDSC2; CTRP2 7.3965 19.202 0.5556 18.9261
MDST8 GDSC1; GDSC2; CTRP2 7.4982 10.7245 4.7764 3.0906
SNU-C4 CTRP2 7.7027 8.8256 5.6803 0.1301
LS1034 GDSC1; GDSC2; CTRP2 8.1572 16.8202 2.2997 11.7614
CW-2 GDSC1; GDSC2; CTRP2 8.4071 14.8007 3.4441 7.0729
RKO GDSC1; GDSC2; CTRP2 8.7786 23.2969 -0.4228 19.4367
SNU-81 GDSC1; GDSC2; CTRP2 10.6132 35.5123 -5.0769 26.2871
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 5.1314 13.8656 -0.5284 14.9725
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-878 CTRP2 0.4879 8.2823 -0.7501 39.9098
Li-7 CTRP2 0.5599 5.895 0.0991 37.8292
SNU-182 CTRP2 2.5743 6.4306 2.1453 24.6183
Huh-7 GDSC1; GDSC2 2.6569 7.3721 0.7191 14.9436
SNU-886 CTRP2 2.6978 5.1674 2.5888 22.6671
JHH-4 GDSC1; GDSC2; CTRP2 3.4292 11.7666 0.7915 26.76
SNU-475 GDSC1; CTRP2 3.8162 7.2057 3.2201 17.0182
JHH-2 GDSC1; GDSC2; CTRP2 3.8283 5.7028 3.7099 15.172
JHH-7 GDSC1; GDSC2 3.8513 14.8367 -2.0005 23.0876
HLE GDSC1; GDSC2 4.3343 17.1237 -2.7544 24.3033
JHH-5 CTRP2 4.4695 18.3193 -1.4504 29.9718
SNU-398 GDSC1; GDSC2; CTRP2 4.6301 12.729 1.4609 21.575
JHH-1 GDSC1; GDSC2; CTRP2 4.7696 11.8668 2.0127 19.2749
HuH-6 CTRP2 4.8543 7.7498 4.072 10.9153
SNU-761 CTRP2 4.8699 9.3939 2.0548 8.2001
Hep-G2/C3A GDSC1; GDSC2 5.0494 12.5401 0.0612 12.6323
SNU-449 GDSC1; GDSC2; CTRP2 5.3326 14.0303 1.4438 20.0549
Hep 3B2.1-7 GDSC1; GDSC2; CTRP2 5.4069 14.5487 1.25 20.5553
PLC/PRF/5 CTRP2 5.5147 7.1708 4.9959 5.5489
HuH-1 GDSC1; GDSC2; CTRP2 6.7777 15.5406 1.8927 15.5784
HLF CTRP2 6.826 15.9999 1.702 16.1726
JHH-6 GDSC1; GDSC2; CTRP2 7.1975 8.3506 5.6523 0.3684
Hep-G2 CTRP2 7.6678 9.0677 5.5783 0.3197
SNU-423 GDSC1; GDSC2; CTRP2 7.8466 33.4254 -6.1747 31.5583
SNU-387 GDSC1; GDSC2; CTRP2 8.6298 21.0626 0.5658 16.8473
SK-HEP-1 GDSC1; GDSC2; CTRP2 12.16 23.1579 1.8869 8.1264
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 222 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H847 GDSC1 -5.147 1.2097 -5.7015 68.0128
IST-SL2 GDSC1; GDSC2 -4.4394 -0.5683 -4.4819 62.2828
NCI-H510A GDSC1; GDSC2 -3.8886 4.9798 -5.0551 62.0627
LK-2 GDSC1; GDSC2 -3.6157 2.1812 -3.9711 55.3029
NCI-H524 GDSC1; GDSC2 -2.9872 0.4071 -3.0383 51.2982
Lu-135 GDSC1; GDSC2 -2.8553 2.0783 -3.1252 50.2413
VMRC-LCD GDSC2; CTRP2 -2.6307 19.7541 -8.9175 52.7454
NCI-H2171 GDSC1; GDSC2; CTRP2 -2.3868 4.7928 -2.8478 55.031
IST-SL1 GDSC1; GDSC2 -2.3366 4.5428 -3.2253 54.4763
NCI-H1436 GDSC1; GDSC2 -2.1949 22.7647 -11.3084 51.1564
NCI-H1963 GDSC2 -1.8674 5.8524 -3.1889 44.5533
LB647-SCLC GDSC1; GDSC2 -1.8322 4.6305 -2.7077 51.1843
NCI-H446 GDSC1; GDSC2; CTRP2 -1.6992 4.9437 -2.1333 51.3438
DV-90 CTRP2 -1.6441 15.0258 -5.7848 50.5593
NCI-H1048 GDSC1; GDSC2 -1.5664 4.5013 -2.3758 41.8274
NCI-H1770 GDSC1; GDSC2 -1.224 6.1935 -2.638 47.249
NCI-H720 GDSC1; GDSC2 -1.2101 5.2537 -2.9974 32.8459
NCI-H2081 GDSC1; GDSC2; CTRP2 -0.9419 10.0934 -2.9704 47.8118
A-427 GDSC1; GDSC2 -0.893 6.4434 -2.3905 38.7552
COR-L279 GDSC2; CTRP2 -0.684 16.5221 -5.4887 47.6959
NCI-H1341 GDSC1; GDSC2; CTRP2 -0.6529 7.8664 -1.8323 45.9823
NCI-H82 GDSC1; GDSC2 -0.6372 6.1684 -2.0087 36.7584
NCI-H211 GDSC1; GDSC2; CTRP2 -0.6315 5.8575 -1.1911 45.2911
NCI-H1184 CTRP2 -0.601 5.9491 -1.1821 45.1366
NCI-H1876 GDSC1; GDSC2 -0.579 9.8866 -3.5902 39.7571
HCC15 GDSC1; GDSC2; CTRP2 -0.5214 5.9568 -1.0973 44.6649
SBC-3 GDSC1; GDSC2 -0.4428 8.7552 -2.9351 38.0883
NCI-H1304 GDSC1 -0.3115 7.4234 -3.1589 35.4078
HCC4006 CTRP2 -0.1838 5.9394 -0.7242 42.6024
NCI-H1581 GDSC1; GDSC2; CTRP2 0.0535 7.9998 -1.1155 42.2077
PC-14 GDSC1; GDSC2; CTRP2 0.0817 6.1308 -0.4866 41.0417
LC-2/ad GDSC1; GDSC2 0.1495 10.0843 -2.9654 40.9832
NCI-H2227 GDSC2 0.238 9.5283 -2.6169 34.9445
UMC-11 GDSC1; GDSC2 0.2556 13.2242 -4.3702 38.2335
LCLC-97TM1 GDSC1; GDSC2; CTRP2 0.4787 10.326 -1.5647 41.2302
Lu-134-A GDSC1; GDSC2 0.5031 7.9974 -1.6413 36.7371
COR-L311 GDSC1; GDSC2 0.6268 12.1595 -3.504 35.5994
HCC33 GDSC1; GDSC2 0.671 7.4353 -1.2152 34.7463
SBC-1 GDSC1; GDSC2 0.708 11.6294 -3.1704 39.153
EPLC-272H GDSC1; GDSC2; CTRP2 0.8621 10.8407 -1.3816 39.6233
COR-L321 GDSC1; GDSC2 0.8889 8.6829 -1.5827 34.911
LXF 289 GDSC1; GDSC2; CTRP2 0.9329 6.5812 0.3107 35.891
NCI-H187 GDSC1 0.956 10.6754 -3.641 31.7597
NCI-H2009 GDSC1; GDSC2; CTRP2 1.011 6.3622 0.4613 35.1998
CPC-N GDSC1; GDSC2 1.0214 9.3267 -1.7617 29.9718
NCI-H810 GDSC1; GDSC2; CTRP2 1.1556 14.6137 -2.7768 40.5839
HCC44 GDSC1; GDSC2; CTRP2 1.1721 6.0838 0.7164 33.8963
NCI-H2286 CTRP2 1.2594 6.8177 0.5924 33.9528
NCI-H1975 GDSC1; GDSC2; CTRP2 1.3297 5.0477 1.1329 32.0591
NCI-H841 GDSC1; GDSC2; CTRP2 1.4536 10.8553 -0.7766 36.577
NCI-H748 GDSC2 1.5736 18.4216 -5.7302 39.9456
DMS 273 GDSC1; GDSC2; CTRP2 1.6383 9.8696 -0.1619 34.634
NCI-H1781 GDSC1; GDSC2 1.6425 9.6309 -1.3222 26.5688
NCI-H64 GDSC1; GDSC2 1.6629 4.0676 1.2644 18.8223
NCI-H1694 GDSC1; GDSC2; CTRP2 1.7574 10.5267 -0.3207 34.6223
NCI-H526 GDSC1; GDSC2; CTRP2 1.8558 12.3221 -1.0231 35.8076
NCI-H23 GDSC1; GDSC2; CTRP2 1.9647 13.1224 -1.283 35.9798
NCI-H69 GDSC1; GDSC2; CTRP2 2.0053 31.6443 -10.26 43.769
NCI-H2085 GDSC1; GDSC2 2.0171 8.784 -0.5604 22.5428
NCI-H1734 GDSC1; GDSC2; CTRP2 2.1799 9.4192 0.5926 30.9312
NCI-H2795 GDSC1; GDSC2 2.1844 10.4948 -1.2516 24.7386
EMC-BAC-2 GDSC1; GDSC2 2.2194 12.9707 -2.4495 28.4854
EBC-1 GDSC1; GDSC2; CTRP2 2.3905 8.6317 1.141 28.6151
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP2 2.3971 11.1962 0.0334 31.799
Lu-99A GDSC1; GDSC2 2.4143 13.179 -2.382 27.7742
NCI-H1155 GDSC1; GDSC2; CTRP2 2.506 14.0857 -1.2046 34.294
ABC-1 GDSC1; GDSC2 2.6221 10.0066 -0.6201 21.0984
HCC78 GDSC1; GDSC2; CTRP2 2.7353 12.8186 -0.382 31.8608
NCI-H647 GDSC1; GDSC2; CTRP2 2.7443 12.3764 -0.1654 31.3046
COR-L47 CTRP2 2.7865 13.7559 -0.7762 32.6281
IA-LM GDSC1; GDSC2; CTRP2 2.8064 6.4095 2.4047 22.9835
HCC1438 CTRP2 2.8765 9.092 1.4553 26.1431
NCI-H1650 GDSC1; GDSC2; CTRP2 2.91 6.6785 2.4317 22.5743
NCI-H1666 GDSC1; GDSC2; CTRP2 2.9118 10.1479 1.0267 27.4482
NCI-H1703 GDSC1; GDSC2; CTRP2 3.0157 9.3463 1.4885 25.6335
NCI-H1563 GDSC1; GDSC2; CTRP2 3.0423 5.9941 2.7818 20.9089
Lu-99 CTRP2 3.0682 7.8256 2.1817 23.0254
RERF-LC-KJ GDSC1; GDSC2 3.0708 11.6703 -1.0634 21.6795
HOP-62 GDSC1; GDSC2; CTRP2 3.0799 10.467 1.0517 26.8959
NCI-H889 CTRP2 3.2031 14.5414 -0.7546 31.4733
SBC-5 GDSC1; GDSC2; CTRP2 3.2754 14.9407 -0.8796 31.5686
NCI-H146 GDSC1; GDSC2; CTRP2 3.4315 11.8048 0.7757 26.8024
NCI-H1755 GDSC1; GDSC2; CTRP2 3.4394 7.0793 2.8643 19.4297
NCI-H358 GDSC1; GDSC2; CTRP2 3.4995 14.197 -0.3078 29.641
A-549 GDSC1; GDSC2; CTRP2 3.5082 11.1575 1.1561 25.395
SK-LU-1 GDSC1; GDSC2; CTRP2 3.574 7.6161 2.8011 19.2876
NCI-H838 GDSC1; GDSC2; CTRP2 3.5776 6.2522 3.2928 17.4382
NCI-H596 GDSC1; GDSC2 3.648 9.9776 0.2618 14.6691
NCI-H1437 GDSC1; GDSC2 3.6641 9.6791 0.4238 16.7484
HOP-92 GDSC2; CTRP2 3.6673 13.2634 0.3029 27.5808
DMS 53 GDSC1; GDSC2; CTRP2 3.7268 7.9777 2.8131 18.8217
NCI-H1105 GDSC1; GDSC2; CTRP2 3.7596 19.093 -2.4698 33.4982
HCC1588 CTRP2 3.7675 16.6595 -1.2625 31.1852
NCI-H250 GDSC2 3.8117 13.3564 -1.2932 20.7499
NCI-H2087 GDSC1; GDSC2; CTRP2 3.8146 10.888 1.5824 23.1535
HCC827 GDSC1; GDSC2; CTRP2 3.8264 11.0472 1.5184 23.3459
NCI-H1573 GDSC1; GDSC2; CTRP2 3.837 13.555 0.3213 27.099
Lu-165 GDSC1; GDSC2 3.9496 12.799 -0.9042 18.9647
NCI-H1385 CTRP2 4.003 6.9128 3.5311 15.3107
NCI-H513 GDSC1; GDSC2 4.0187 7.4756 1.7933 6.3479
NCI-H1355 GDSC1; GDSC2; CTRP2 4.0235 14.6234 -0.0271 27.6036
RERF-LC-MS GDSC1; GDSC2; CTRP2 4.0376 9.1015 2.6357 18.6846
LK2 CTRP2 4.069 10.6903 1.9229 21.292
NCI-H1693 GDSC2; CTRP2 4.209 9.6008 2.5744 18.4872
Lu-139 GDSC1; GDSC2 4.2121 17.8019 -3.1903 25.7498
NCI-H2369 GDSC1; GDSC2 4.2441 9.1012 1.1602 9.0606
NCI-H1568 GDSC1; GDSC2; CTRP2 4.2468 8.759 3.0019 16.7199
Calu-1 CTRP2 4.249 12.1385 1.3967 22.7057
LOU-NH91 GDSC1; GDSC2; CTRP2 4.2649 11.3088 1.8139 21.202
NCI-H209 GDSC1; GDSC2 4.2768 22.9276 -5.697 30.9325
HCC1195 CTRP2 4.301 12.6357 1.2029 23.2321
HCC2935 CTRP2 4.3148 6.988 3.8357 13.2747
NCI-H2803 GDSC1; GDSC2 4.3595 12.5924 -0.4795 16.3484
HCC1171 CTRP2 4.3982 7.6557 3.6478 13.7788
COR-L23 GDSC1; GDSC2 4.3982 13.4259 -0.8635 17.8157
NCI-H2347 GDSC1; GDSC2 4.4007 11.5821 0.0529 16.6655
NCI-H2731 GDSC1; GDSC2 4.4292 12.3194 -0.2906 15.405
NCI-H2228 GDSC1; GDSC2; CTRP2 4.4874 14.2757 -0.6774 20.5323
NCI-H2170 GDSC1; GDSC2; CTRP2 4.4892 10.8752 2.2359 19.0985
NCI-H290 GDSC1; GDSC2 4.5034 14.2463 -1.1895 21.8434
NCI-H1793 GDSC1; GDSC2; CTRP2 4.506 12.1525 1.6295 21.2788
NCI-H1648 GDSC1; GDSC2 4.5223 17.7587 -2.9221 27.3781
HCC366 GDSC2; CTRP2 4.5398 8.5592 3.3862 14.4549
Sq-1 CTRP2 4.564 7.6076 3.8397 12.5866
NCI-H2810 GDSC1; GDSC2 4.6102 13.4789 -0.727 16.8262
NCI-H661 GDSC1; GDSC2; CTRP2 4.69 14.5138 0.634 24.126
NCI-H3255 GDSC1; GDSC2 4.6915 13.0404 -0.4485 15.5234
NCI-H345 GDSC1; GDSC2 4.6989 5.6614 3.009 0.1505
NCI-H2110 GDSC1; GDSC2; CTRP2 4.7714 11.1826 2.3501 17.9989
T3M-10 CTRP2 4.8005 7.622 4.0752 11.0396
NCI-H2461 GDSC1; GDSC2 4.8277 12.1488 0.0919 12.9272
Calu-3 GDSC1; GDSC2; CTRP2 4.8304 14.6176 0.7084 23.5767
RERF-LC-A1 CTRP2 4.8507 9.0522 3.4583 13.408
PaCa-3 GDSC1; GDSC2 4.8927 14.8333 -1.1829 20.8537
EKVX GDSC1; GDSC2; CTRP2 5.0275 12.0802 2.1422 18.2052
NCI-H3122 GDSC1; GDSC2 5.0335 15.0919 -1.2046 17.7962
NCI-H1792 GDSC1; GDSC2; CTRP2 5.0707 13.7398 1.3579 20.9237
NCI-H226 GDSC1; GDSC2; CTRP2 5.0979 9.8914 3.2846 13.5434
LC-1/sq GDSC2 5.1412 12.351 0.219 11.761
SK-MES-1 GDSC1; GDSC2; CTRP2 5.1751 15.1244 0.7611 22.6448
NCI-H1339 CTRP2 5.1813 10.3449 3.1384 13.9518
NCI-H2722 GDSC1; GDSC2 5.1923 15.1657 -1.1227 17.176
DMS 114 GDSC1; GDSC2; CTRP2 5.2069 13.6808 1.5077 20.1068
Lu-65 GDSC1; GDSC2; CTRP2 5.2263 11.9708 2.3745 16.8812
NCI-H1688 GDSC1; GDSC2 5.2328 8.0826 2.2823 2.6838
NCI-H2373 GDSC1; GDSC2 5.2912 13.9137 -0.436 14.286
NCI-H1373 CTRP2 5.3256 9.6194 3.6274 11.6287
RERF-LC-Sq1 GDSC1; GDSC2 5.3378 20.4121 -3.6068 24.5564
LUDLU-1 CTRP2 5.3412 8.1786 4.3466 8.6204
COR-L32 GDSC2 5.3928 16.5652 -1.6631 21.4561
CAL-12T GDSC1; GDSC2; CTRP2 5.4426 15.7505 0.6811 22.3164
SW1271 GDSC1; GDSC2; CTRP2 5.5026 12.0641 2.5719 15.5208
COR-L105 GDSC1; GDSC2; CTRP2 5.5107 13.5432 1.8414 18.2645
HCC95 CTRP2 5.5757 15.7658 0.7878 21.702
NCI-H2106 CTRP2 5.5893 15.0182 1.1728 20.4265
COLO 668 GDSC1; GDSC2; CTRP2 5.641 9.8684 3.7866 10.2925
DMS 454 CTRP2 5.679 11.8109 2.8513 14.0466
NCI-H740 GDSC2 5.6872 15.1001 -0.7313 17.1963
NCI-H835 GDSC2 5.6969 7.7517 2.6375 0.7127
Calu-6 GDSC1; GDSC2; CTRP2 5.7188 15.5543 1.0155 20.6741
NCI-H2804 GDSC1; GDSC2 5.7392 15.3046 -0.7939 14.8815
EMC-BAC-1 GDSC1; GDSC2 5.7622 18.9185 -2.5479 23.5146
NCI-H322M GDSC1; GDSC2 5.7926 12.1782 0.7447 8.2691
NCI-H2591 GDSC1; GDSC2 5.8275 18.0729 -2.0839 19.2967
NCI-H1869 GDSC1; GDSC2; CTRP2 5.8404 10.8661 3.4615 11.2335
NCI-H2122 GDSC1; GDSC2; CTRP2 5.8638 12.1303 2.8496 13.6768
COR-L88 GDSC1; GDSC2; CTRP2 5.9069 19.4232 -0.7599 25.3687
COLO 699 CTRP2 5.9204 14.8461 1.5398 18.4903
NCI-H2023 GDSC1; GDSC2; CTRP2 5.9337 12.3078 2.82 13.6553
NCI-H2196 GDSC1; GDSC2; CTRP2 6.0475 7.8757 5.1313 3.8318
HCC2108 CTRP2 6.0833 17.7836 0.2072 22.4191
NCI-H322 CTRP2 6.1634 12.6985 2.816 13.2202
NCI-H2066 GDSC1; GDSC2 6.2205 14.7902 -0.2135 13.8065
LC-1/sq-SF CTRP2 6.2994 8.7239 4.9108 4.2949
NCI-H1944 GDSC1; GDSC2; CTRP2 6.3933 16.8469 0.9311 19.5974
NCI-H1838 GDSC1; GDSC2; CTRP2 6.5202 14.5533 2.1796 14.9999
NCI-H2818 GDSC1; GDSC2 6.538 19.1754 -2.1107 18.1068
NCI-H1092 GDSC1; GDSC2; CTRP2 6.5902 17.1458 0.9417 19.1862
COR-L95 GDSC2; CTRP2 6.694 9.3732 4.8854 3.7516
NCI-H1299 GDSC1; GDSC2; CTRP2 6.7499 16.9143 1.1856 18.0873
Ms-1 GDSC1; GDSC2 6.7827 19.1419 -1.9225 17.0784
HCC2279 CTRP2 6.8417 15.9063 1.7611 15.9337
SW1573 GDSC1; GDSC2 6.844 21.5081 -3.0292 20.327
ChaGo-K-1 GDSC1; GDSC2; CTRP2 6.8604 17.1357 1.1632 17.9569
NCI-H1993 GDSC1; GDSC2 6.9386 21.1607 -2.7926 19.496
MOR/CPR CTRP2 7.0625 8.2619 5.6253 0.5237
NCI-H1836 GDSC1; GDSC2 7.0757 21.7869 -3.0001 22.1982
NCI-H2869 GDSC1; GDSC2 7.1566 18.1674 -1.1997 13.9782
RERF-LC-Ad1 CTRP2 7.16 8.364 5.6299 0.448
NCI-H1395 CTRP2 7.3038 18.6162 0.7748 18.4106
NCI-H2135 GDSC1; GDSC2 7.3047 18.6996 -1.3547 14.2937
NCI-H522 GDSC1; GDSC2; CTRP2 7.3259 20.8383 -0.3136 21.5526
RERF-LC-Ad2 CTRP2 7.3634 15.5975 2.3176 12.9783
NCI-H727 GDSC1; GDSC2; CTRP2 7.465 15.938 2.2258 13.1488
BEN GDSC1; GDSC2; CTRP2 7.5646 8.4326 5.7664 0.0555
NCI-H460 GDSC1; GDSC2; CTRP2 7.5974 11.1004 4.6637 3.4014
DMS 79 GDSC2; CTRP2 7.6206 10.3124 5.0367 1.9906
NCI-H2595 GDSC1; GDSC2 7.6605 21.6094 -2.5075 17.483
NCI-H2342 GDSC1; GDSC2; CTRP2 7.6868 17.0415 1.8474 14.1517
COR-L303 GDSC1; GDSC2 7.9101 20.6574 -1.8849 17.2143
NCI-H1651 GDSC1; GDSC2 7.945 20.6052 -1.8372 14.9405
NCI-H2444 GDSC1; GDSC2; CTRP2 7.9481 17.7022 0.1658 11.1588
NCI-H520 GDSC1; GDSC2; CTRP2 7.9802 19.3159 0.9447 16.7132
LCLC-103H GDSC1; GDSC2; CTRP2 8.0166 9.0114 5.7277 0.0385
NCI-H2126 CTRP2 8.1643 9.4817 5.6201 0.1147
NCI-H2141 GDSC1; GDSC2; CTRP2 8.1757 20.9102 0.3043 18.358
SHP-77 GDSC1; GDSC2; CTRP2 8.181 9.602 5.5844 0.1555
NCI-H196 GDSC1; GDSC2; CTRP2 8.7304 17.7681 2.2419 11.1141
NCI-H2029 GDSC1; GDSC2; CTRP2 8.7464 19.1941 1.5626 13.4643
HCC1833 CTRP2 8.8547 20.0514 1.2223 14.4322
KNS-62 GDSC1; GDSC2; CTRP2 9.148 20.3278 1.2947 13.76
NCI-H2291 GDSC1; GDSC2; CTRP2 9.175 18.8343 2.0328 11.2223
NCI-H292 GDSC1; GDSC2; CTRP2 9.321 25.0672 -0.8936 19.832
NCI-H441 GDSC1; GDSC2; CTRP2 9.3236 21.4545 0.8715 14.855
NCI-H2405 GDSC1; GDSC2; CTRP2 9.5672 20.9525 1.2826 13.1984
NCI-H2172 GDSC1; GDSC2; CTRP2 10.0785 19.2581 2.4204 8.6899
NCI-H1623 GDSC1; GDSC2; CTRP2 10.0933 22.0586 1.1084 13.0316
NCI-H1435 GDSC1; GDSC2; CTRP2 10.8194 21.8938 1.6576 10.3472
NCI-H1915 GDSC1; GDSC2; CTRP2 10.8322 28.9371 -1.699 19.6324
NCI-H2030 GDSC1; GDSC2; CTRP2 11.3555 23.2651 1.355 10.6691
NCI-H650 GDSC1; GDSC2; CTRP2 11.9124 31.7933 -2.3286 19.6327
Hs 888.Lu CTRP2 5.2407 12.8242 1.9634 18.3991
⏷ Show the Full List of 222 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 3.5404 10.9538 -0.3135 17.4925
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 -1.2115 3.4044 -1.3404 48.431
SYO-1 CTRP2 4.7937 16.7411 -0.3789 26.7394
P-STS CTRP2 7.4057 13.1103 3.5716 8.011
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 3.1881 11.7019 0.5866 28.0254
A2780 GDSC1; GDSC2; CTRP2 -1.723 6.0273 -2.4278 51.3755
Caov-3 GDSC1; GDSC2; CTRP2 -1.7069 11.1725 -4.2112 50.9268
TOV-112D GDSC1; GDSC2; CTRP2 -0.1597 13.798 -3.726 45.4143
SNU-8 CTRP2 0.9645 4.7832 0.7869 34.4115
ES-2 GDSC1; GDSC2 1.2169 2.5583 1.1793 17.2876
OV7 CTRP2 1.7812 9.0847 0.3145 32.966
Caov-4 GDSC1; GDSC2 2.0098 10.6775 -1.4994 30.3807
JHOS-4 GDSC1; GDSC2 2.3111 7.393 0.3928 21.2299
TOV-21G GDSC1; GDSC2 2.3576 12.8889 -2.2872 27.6484
ES2 CTRP2 2.4626 2.9948 2.4626 23.8624
OVISE GDSC1; GDSC2; CTRP2 2.4797 3.8237 2.4761 23.7608
COV434 CTRP2 2.7722 19.6368 -3.6401 37.4677
IGROV-1 GDSC1; GDSC2; CTRP2 3.1617 13.7773 -0.4258 30.8099
MCAS CTRP2 3.1652 13.4917 -0.2855 30.4558
SNU-119 CTRP2 3.7233 6.4766 3.3814 16.6796
FU-OV-1 GDSC1; GDSC2; CTRP2 3.8137 10.0781 1.9619 21.8006
OVTOKO GDSC1; GDSC2; CTRP2 4.1333 9.7674 2.422 19.2636
OC 314 GDSC1; GDSC2; CTRP2 4.2163 12.5031 1.1886 23.4854
ONCO-DG-1 CTRP2 4.3118 9.1527 2.8849 17.0169
OVCAR-3 GDSC1; GDSC2 4.4216 12.2583 -0.2662 15.3166
OVCAR-5 GDSC1; GDSC2; CTRP2 4.5983 10.4894 2.5257 17.7272
OVK18 GDSC1; GDSC2; CTRP2 4.6494 12.2912 1.6939 20.7127
JHOM-1 CTRP2 4.6968 7.9796 3.8091 12.3665
OVCAR-8 GDSC1; GDSC2; CTRP2 4.7578 12.9835 1.4519 21.3097
OVCAR-4 GDSC1; GDSC2; CTRP2 4.8426 10.3793 2.8089 16.0424
RMG-I GDSC1; GDSC2; CTRP2 4.9677 9.0374 3.5773 12.6473
HEY A8 CTRP2 5.0616 11.7066 2.3576 17.3101
TYK-nu GDSC1; GDSC2; CTRP2 5.1638 11.8987 2.3544 17.0958
OVKATE GDSC1; GDSC2 5.4296 10.7636 1.1768 8.3687
SNU-840 CTRP2 5.4816 8.5164 4.3129 8.4423
OAW28 GDSC1; GDSC2; CTRP2 5.5658 13.9403 1.6909 18.6899
EFO-27 GDSC1; GDSC2; CTRP2 5.6305 10.7084 3.3591 12.0848
Kuramochi GDSC1; GDSC2; CTRP2 5.8205 10.1991 3.7776 9.9613
OV56 GDSC1; GDSC2; CTRP2 5.8699 8.8185 4.5094 6.7969
JHOS-2 GDSC1; GDSC2; CTRP2 5.9236 8.0637 4.9323 4.9129
EFO-21 GDSC1; GDSC2; CTRP2 5.9785 14.2875 1.8678 17.2037
COV362 CTRP2 6.1272 12.6434 2.8137 13.2995
OAW42 GDSC1; GDSC2; CTRP2 6.3682 13.1581 2.7537 13.0761
SK-OV-3 GDSC1; GDSC2; CTRP2 6.6064 10.9426 4.0464 7.3691
COV644 CTRP2 6.6428 10.9884 4.0516 7.2851
OV-90 GDSC1; GDSC2; CTRP2 8.1089 10.2124 5.327 0.6983
DOV13 GDSC1; GDSC2; CTRP2 8.3864 22.6815 -0.4122 20.0303
OVSAHO CTRP2 9.0946 10.3959 5.6322 0.0228
JHOC-5 CTRP2 10.0887 15.5675 4.0812 2.9862
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.4352 11.4788 4.3806 4.7188
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 7.8574 13.3972 3.7471 6.6454
Aska-SS CTRP2 9.1586 20.8622 1.0431 14.5565
EW-8 GDSC1; GDSC2 -4.5793 -2.692 -4.5795 64.2643
G-401 GDSC1; GDSC2; CTRP2 0.3859 12.4563 -2.5741 42.7425
STS-0421 GDSC2 0.5792 8.5425 -1.8195 36.8672
Hs 633.T GDSC1; GDSC2 0.7177 14.9372 -4.7769 41.324
Rh41 GDSC1; GDSC2; CTRP2 1.2418 8.9798 -0.2128 36.0792
RKN GDSC1; GDSC2; CTRP2 1.5117 3.1858 1.5078 30.2105
MES-SA GDSC1; GDSC2 1.6991 12.0518 -2.4596 29.9556
VA-ES-BJ GDSC1; GDSC2 2.6664 12.7981 -1.9729 25.8779
TTC-709 CTRP2 2.948 13.2426 -0.3758 31.261
Rh18 GDSC1; CTRP2 3.0861 5.3958 2.9671 20.1161
G-402 GDSC1; GDSC2; CTRP2 3.2481 14.5 -0.692 31.2134
A-204 GDSC1; GDSC2; CTRP2 3.5076 9.9537 1.7149 23.4942
MFH-ino GDSC1; GDSC2 3.5918 6.88 1.7624 9.1001
SW684 GDSC1; GDSC2 3.7056 8.5646 1.0131 10.9232
TE 441.T GDSC1; GDSC2; CTRP2 3.9443 15.7516 -0.654 29.3883
GCT GDSC1; GDSC2; CTRP2 4.7043 16.8107 -0.4927 27.2294
SW982 GDSC1; GDSC2; CTRP2 4.8279 20.5373 -2.2392 30.7802
Rh30 GDSC1; GDSC2 4.8298 17.2956 -2.4515 22.3858
HT-1080 GDSC1; GDSC2; CTRP2 5.1364 8.7434 3.8796 11.0162
TE 617.T CTRP2 5.4648 12.6849 2.2296 16.9203
RD GDSC1; GDSC2; CTRP2 5.5834 15.2181 1.0679 20.7857
KYM-1 GDSC1; GDSC2; CTRP2 5.97 26.8207 -4.4058 32.1632
SK-LMS-1 GDSC1; GDSC2; CTRP2 6.5711 21.3247 -1.1613 25.069
BT-12 CTRP2 6.6538 9.1667 4.9574 3.5186
SW872 GDSC1; GDSC2 7.4656 22.2385 -2.9453 19.0686
BT-16 CTRP2 7.5894 13.4652 3.5294 7.8994
Hs 729.T CTRP2 8.9517 17.5995 2.4732 9.9648
Tm87-16 CTRP2 9.1095 23.8231 -0.4378 18.9672
SK-UT-1 GDSC1; GDSC2; CTRP2 10.3336 29.4779 -2.3185 21.675
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; GDSC2; CTRP2 1.9663 7.3632 1.1749 29.8265
NCI-H28 GDSC1; GDSC2; CTRP2 2.4548 8.2426 1.3659 27.6854
NCI-H2452 GDSC1; GDSC2; CTRP2 4.3614 9.8556 1.4284 12.1647
ACC-MESO-1 CTRP2 5.0221 7.4031 4.3981 9.1846
MPP 89 GDSC1; GDSC2; CTRP2 5.1905 10.0084 3.3125 13.2222
NCI-H2052 GDSC1; GDSC2; CTRP2 5.7119 11.8116 2.8792 13.8672
IST-Mes1 GDSC1; GDSC2; CTRP2 6.0999 19.437 -0.6057 24.5998
JL-1 CTRP2 7.0131 13.1044 3.2856 9.7979
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1; GDSC2; CTRP2 4.5946 7.7411 3.8124 12.6152
LNCaP clone FGC GDSC1; GDSC2; CTRP2 5.674 15.9273 0.791 21.4863
VCaP GDSC1; GDSC2; CTRP2 5.7122 17.9112 -0.1681 24.221
PaCa-3 CTRP2 6.1335 8.9324 4.674 5.5905
NCI-H660 GDSC2; CTRP2 6.2355 12.0156 3.2165 11.4688
PC-3 GDSC1; GDSC2 7.1858 19.347 -1.7441 15.8196
22Rv1 GDSC1; GDSC2; CTRP2 10.5247 25.8927 -0.4395 16.9379
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 5.8471 18.999 -2.5246 20.6288
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 -3.2203 1.5084 -3.4169 52.8901
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1; GDSC2 -4.1598 -0.8568 -4.1804 72.5338
SNU-16 GDSC1; GDSC2; CTRP2 -2.7473 0.2906 -2.7521 58.4858
HGC-27 GDSC1; GDSC2; CTRP2 -2.3531 6.704 -3.3084 54.2805
SNU-620 CTRP2 -0.9359 3.3013 -1.0366 46.6454
ECC10 GDSC1; GDSC2; CTRP2 -0.8435 6.751 -1.6767 46.7328
GCIY GDSC1; GDSC2 0.9738 5.4973 -0.0438 23.6245
KATO III GDSC1; GDSC2; CTRP2 1.8251 7.3883 1.0136 30.7925
MKN1 GDSC1; GDSC2; CTRP2 2.2001 10.6133 0.095 32.2302
RF-48 GDSC1; GDSC2 2.2168 14.2528 -3.0897 30.1823
RERF-GC-1B GDSC1; GDSC2 3.0197 12.3951 -1.4689 23.2901
GSS CTRP2 3.1142 9.3468 1.5893 25.0104
OCUM-1 GDSC1; GDSC2 3.4532 12.9776 -1.3969 21.968
ECC12 GDSC2; CTRP2 3.9802 5.4636 3.9196 13.9583
SNU-216 CTRP2 4.1611 13.0852 0.8532 24.7021
LMSU CTRP2 4.1949 9.0474 2.8177 17.5752
23132/87 GDSC1; GDSC2; CTRP2 4.4653 7.8916 3.6137 13.7376
TMK-1 GDSC2 5.0168 19.4708 -3.3872 27.4402
SNU-1 GDSC1; GDSC2; CTRP2 5.2548 7.0063 4.812 6.9375
HuG1-N CTRP2 5.4468 11.0521 3.0267 13.8274
SNU-601 CTRP2 5.4924 8.5814 4.2909 8.5099
SK-GT-2 GDSC2 5.614 13.7836 -0.1438 12.4693
MKN7 GDSC1; GDSC2; CTRP2 5.6505 13.0521 2.2071 16.6154
MKN74 CTRP2 5.6724 10.7961 3.3518 12.0278
MKN28 GDSC1; GDSC2 5.9609 12.97 0.4801 9.177
SH-10-TC CTRP2 5.9977 9.2292 4.4129 6.9478
TGBC11TKB GDSC1; GDSC2 6.0127 7.6016 2.812 0.1408
GSU CTRP2 6.1706 7.8799 5.2296 3.1891
Fu97 GDSC1; GDSC2; CTRP2 6.7524 13.1894 3.0434 11.2211
Hs 746.T GDSC1; GDSC2; CTRP2 6.7955 17.1336 1.1126 18.2441
MKN45 GDSC1; GDSC2; CTRP2 6.9662 14.2949 2.66 12.3568
KE-39 CTRP2 7.9346 17.7609 1.6771 14.3427
SCH GDSC1; GDSC2 8.1888 26.3876 -4.4497 23.9037
SNU-5 GDSC1; GDSC2; CTRP2 8.3936 21.8193 0.0189 18.8295
IM95 GDSC1; GDSC2; CTRP2 8.4524 19.9921 0.9614 15.8961
SNU-668 CTRP2 9.532 17.8634 2.727 8.283
NCI-N87 GDSC1; GDSC2; CTRP2 9.7083 23.3743 0.2104 16.2802
NUGC-4 GDSC1; GDSC2; CTRP2 9.9347 23.9262 0.1014 16.2694
AGS GDSC1; GDSC2; CTRP2 10.0592 16.5921 3.6212 4.5318
NUGC-3 GDSC1; GDSC2; CTRP2 10.0907 21.1086 1.5587 11.5869
SNU-719 CTRP2 10.88 21.8109 1.7342 10.0264
SNU-1077 CTRP2 2.7507 4.0886 2.7453 21.9612
SNG-M GDSC1; GDSC2; CTRP2 4.8041 17.9239 -0.9582 28.1404
SNU-685 CTRP2 5.1459 12.2224 2.178 17.8071
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1; GDSC2 1.2279 7.5969 -0.7392 25.6895
FTC-238 CTRP2 1.4681 7.6875 0.5216 33.4361
CGTH-W-1 GDSC1; GDSC2; CTRP2 3.1159 5.0521 3.0546 19.7177
ASH-3 GDSC1; GDSC2 3.6864 10.5345 0.0147 15.7086
KMH-2 GDSC1; GDSC2 3.7343 13.8113 -1.5832 25.3206
IHH-4 GDSC1; GDSC2 3.7816 15.5562 -2.4165 24.5348
ML-1 [Human leukemia] GDSC1; GDSC2; CTRP2 3.989 11.4876 1.4649 23.1168
BHT-101 GDSC1; GDSC2; CTRP2 4.3222 13.9089 0.5985 25.0963
HTC-C3 GDSC1; GDSC2 4.3947 11.8035 -0.0614 14.4851
B-CPAP GDSC1; GDSC2; CTRP2 4.5132 15.6064 -0.0658 26.5475
SW579 CTRP2 4.6079 7.2354 4.0447 11.6651
FTC-133 GDSC2; CTRP2 4.8944 12.8393 1.6467 20.3158
8505C GDSC1; GDSC2; CTRP2 4.9708 12.9092 1.6808 20.0219
TT2609-C02 GDSC1; GDSC2; CTRP2 5.0577 16.898 -0.2251 25.7553
8305C GDSC1; GDSC2; CTRP2 5.2805 14.2329 1.2973 20.6684
CAL-62 GDSC1; GDSC2; CTRP2 7.3459 12.7926 3.6839 7.6513
TT GDSC1; GDSC2; CTRP2 7.4448 16.5104 1.9277 14.2717
WRO GDSC1; GDSC2 8.8689 21.1314 -1.4941 12.4807
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-06A GDSC1; GDSC2 -1.8369 1.7128 -1.9643 51.6103
HO-1-N-1 GDSC1; GDSC2 -1.2489 6.016 -2.5938 40.7364
BB30-HNC GDSC1; GDSC2 -0.6915 5.0742 -1.6361 42.8427
JHU-011 GDSC1; GDSC2 -0.1545 5.6983 -1.3087 39.0549
CAL-27 GDSC1; GDSC2; CTRP2 -0.1327 7.0491 -0.9958 42.804
DOK GDSC1; GDSC2 0.5887 10.1503 -2.5715 33.6524
CAL-33 GDSC1; GDSC2; CTRP2 0.9077 7.5519 -0.0351 36.8507
PCI-15A GDSC1; GDSC2 2.0387 10.3696 -1.3212 29.6816
UPCI-SCC-090 GDSC2 2.4294 10.379 -0.9755 23.0296
SNU-1214 CTRP2 2.5023 10.0002 0.6749 29.7147
SNU-1076 CTRP2 2.6148 9.5982 0.9662 28.4976
SAT [Human HNSCC] GDSC1; GDSC2 2.66 13.1092 -2.1337 26.3948
KOSC-2 GDSC1; GDSC2 2.8066 13.1693 -2.0376 29.4737
PE/CA-PJ34 (clone C12) CTRP2 2.8121 9.8451 1.0602 27.627
OSC-20 GDSC1; GDSC2 2.8362 16.05 -3.4513 29.5068
PCI-04B GDSC1; GDSC2 2.9264 14.0391 -2.3697 26.4273
PCI-38 GDSC1 3.0285 9.8627 -1.5968 16.1887
PE/CA-PJ49 CTRP2 3.0521 9.4166 1.4949 25.509
LB771-HNC GDSC1; GDSC2 3.1742 13.5046 -1.893 24.3391
BICR 10 GDSC1; GDSC2 3.2374 14.1025 -3.5252 21.0584
JHU-029 GDSC2 3.2522 17.0193 -3.5849 32.1498
SCC-25 GDSC1; GDSC2; CTRP2 3.2545 11.4958 0.7485 27.3602
BICR 56 CTRP2 3.3395 12.6034 0.3069 28.4233
YD-8 CTRP2 3.4149 5.0684 3.3705 17.6681
BB49-HNC GDSC1; GDSC2 3.4432 13.5057 -3.0792 18.9274
Ca9-22 GDSC1; GDSC2 3.5149 8.2872 0.9982 11.4284
BICR 18 CTRP2 3.7606 12.1325 0.9367 25.4421
HO-1-u-1 GDSC1; GDSC2 3.8658 7.3091 1.7615 8.3875
HSC-2 GDSC1; GDSC2; CTRP2 3.9271 10.9299 1.6717 22.5524
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 3.9714 10.3057 2.0103 21.2187
KON GDSC1; GDSC2 4.1899 13.3844 -1.0055 21.9351
SAS GDSC1; GDSC2 4.5899 15.7783 -1.8837 21.0899
HSC-4 GDSC1; GDSC2; CTRP2 4.6169 13.0557 1.2881 22.1955
SCC-15 GDSC1; GDSC2 5.0712 17.656 -2.4446 21.878
JHU-022 GDSC1; GDSC2 5.1865 15.9641 -1.5205 18.631
PE/CA-PJ41 (clone D2) CTRP2 5.2159 10.1344 3.2736 13.3245
SCC-4 GDSC2; CTRP2 5.295 17.5233 -0.331 25.5259
BICR 22 GDSC1; GDSC2; CTRP2 5.2964 20.2851 -1.7085 28.7651
BICR 78 GDSC1; GDSC2 5.3591 19.8595 -3.3165 23.7724
BICR 6 CTRP2 5.4219 13.9078 1.5827 19.3785
FaDu GDSC1; GDSC2; CTRP2 5.5317 10.6721 3.2905 12.5729
NCI-H3118 GDSC1; GDSC2 5.6611 16.0311 -1.2043 16.5791
Detroit 562 GDSC1; GDSC2; CTRP2 5.77 19.651 -0.9889 26.1987
OSC-19 GDSC1; GDSC2 5.9164 19.4457 -2.6931 23.6169
SCC-9 GDSC1; GDSC2; CTRP2 6.2867 20.4503 -0.9577 25.1157
BHY GDSC1; GDSC2; CTRP2 6.578 16.7106 1.1492 18.5309
BICR 31 GDSC1; GDSC2; CTRP2 6.5874 18.2976 0.3642 20.9803
SKN-3 GDSC1; GDSC2 7.5428 22.9297 -3.2261 19.7236
SNU-1066 CTRP2 7.6992 16.4886 2.129 13.116
SNU-1041 CTRP2 8.346 9.8195 5.5688 0.1421
SNU-899 CTRP2 8.5677 10.376 5.455 0.2497
PCI-30 GDSC1; GDSC2 8.794 22.2146 -2.0463 16.273
HSC-3 GDSC1; GDSC2; CTRP2 8.8222 19.8502 1.2972 14.236
SNU-46 CTRP2 9.8278 33.0052 -4.4275 26.2974
BICR 16 CTRP2 10.2595 24.8962 -0.1419 16.4962
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 GDSC1; GDSC2; CTRP2 -1.0107 4.6158 -1.3173 47.3071
RT-112 GDSC1; GDSC2; CTRP2 0.9838 7.2044 0.1663 36.0805
BFTC-905 GDSC1; GDSC2 1.2982 9.0683 -1.3732 27.809
U-BLC1 CTRP2 1.7253 11.1478 -0.6265 35.4005
JMSU-1 CTRP2 1.7846 4.3153 1.7289 28.5663
RT-4 GDSC1; GDSC2; CTRP2 2.9611 7.9096 2.0349 23.8665
SCaBER CTRP2 3.4739 13.0856 0.2048 28.3543
VM-CUB-1 CTRP2 3.6521 10.0347 1.8219 22.7295
TCCSUP GDSC1; GDSC2; CTRP2 3.7476 9.3076 2.2505 20.9051
UM-UC-1 CTRP2 4.4857 10.1365 2.5887 17.7516
SW780 GDSC1; GDSC2 4.6656 14.6557 -1.2678 18.7825
HT-1376 GDSC1; GDSC2; CTRP2 4.7079 7.7167 3.9388 11.8206
253J CTRP2 4.8743 8.5061 3.7408 12.2037
BC-3C CTRP2 5.0255 9.5904 3.3642 13.3834
253J-BV CTRP2 5.2767 8.7943 3.9869 10.2525
UM-UC-3 GDSC1; GDSC2; CTRP2 5.4811 13.5055 1.8346 18.3521
SW1710 GDSC1; GDSC2; CTRP2 5.6578 13.9857 1.7472 18.2955
647V GDSC1; GDSC2; CTRP2 5.6952 13.0225 2.2602 16.3211
639V GDSC1; GDSC2; CTRP2 5.7533 12.048 2.7967 14.112
J82 GDSC1; GDSC2; CTRP2 5.7952 10.8264 3.4427 11.4024
HT-1197 GDSC1; GDSC2; CTRP2 5.7972 9.6581 4.0276 8.9644
KMBC-2 CTRP2 5.9218 18.3057 -0.1887 23.8529
CAL-29 GDSC1; GDSC2; CTRP2 6.0673 11.4032 3.384 11.1054
T24 GDSC1; GDSC2; CTRP2 6.6096 15.0141 2.0215 15.4193
KU-19-19 GDSC1; GDSC2; CTRP2 11.0789 26.7591 -0.4771 16.3001
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TC-YIK GDSC1; GDSC2 -3.6705 -1.3361 -3.6734 56.862
PA-1 GDSC1; GDSC2 -2.9995 6.0249 -4.466 50.9178
SW954 GDSC1; GDSC2 -2.1481 1.6139 -2.283 54.3778
BPH-1 GDSC1; GDSC2 -0.49 6.8222 -2.1286 36.4619
KGN GDSC1; GDSC2 -0.3062 9.8742 -3.3141 43.3575
HEY GDSC1; GDSC2 0.6058 6.1353 -0.6993 27.6459
CAL-39 GDSC1; GDSC2 0.7329 6.7362 -0.8354 27.7268
MS751 GDSC1; GDSC2 1.1285 9.0598 -1.5311 28.8839
NT2-D1 GDSC1; GDSC2 1.2227 13.1104 -3.4157 37.7791
ACC-OV7 GDSC1; GDSC2 1.2793 7.3306 -0.5637 29.7482
PWR-1E GDSC1; GDSC2 1.4643 8.6439 -1.0106 25.982
Ca Ski GDSC1; GDSC2 1.8758 9.3762 -0.9812 24.6238
NEC8 GDSC1; GDSC2 2.1305 10.9518 -1.5264 25.8572
C-4-I GDSC1; GDSC2 2.7368 8.1224 0.4182 16.1824
JAR GDSC1; GDSC2 3.0554 6.5523 1.4796 12.4267
OV17R GDSC1; GDSC2 3.0756 9.0699 0.2402 19.4731
SiSo GDSC1; GDSC2 3.3097 11.9442 -0.9995 20.8418
C-33 A GDSC1; GDSC2 3.4326 10.0256 0.0618 16.0924
OVMIU GDSC1; GDSC2 3.4495 7.6422 1.2672 10.2309
OVCA433 GDSC1; GDSC2 3.7436 12.8306 -1.0857 23.4656
ME-180 GDSC1; GDSC2 3.8323 14.5118 -1.8536 22.6515
SKN GDSC1; GDSC2 4.004 10.478 0.2952 13.7145
JHOS-3 GDSC1; GDSC2 4.0711 7.3846 1.876 7.1801
UWB1.289 GDSC1; GDSC2 4.1744 15.9556 -2.2993 26.4692
OVCA420 GDSC1; GDSC2 4.1752 10.4924 0.4206 15.3702
DoTc2 4510 GDSC1; GDSC2 4.317 17.9746 -3.1926 25.534
SW962 GDSC1; GDSC2 4.3383 7.8621 1.8329 6.8328
DSH1 GDSC1; GDSC2 4.6324 12.2222 -0.0889 14.1133
LB831-BLC GDSC1; GDSC2 4.6836 16.3707 -2.1053 21.6139
HEC-1 GDSC1; GDSC2 4.6984 6.8546 2.5279 1.7563
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.8038 11.7663 0.262 14.6199
SKG-IIIa GDSC1; GDSC2 4.9071 18.8401 -3.159 24.237
SiHa GDSC1; GDSC2 4.9217 11.9508 0.2572 12.0057
JEG-3 GDSC1; GDSC2 5.1234 8.9074 1.8495 5.1846
PEO1 GDSC1; GDSC2 5.5253 13.1971 0.0782 11.6779
SW756 GDSC1; GDSC2 5.8277 15.4239 -0.7893 14.7021
HT-3 GDSC1; GDSC2 5.8708 15.4862 -0.7892 14.624
NCC-IT GDSC1; GDSC2 6.2934 21.6696 -3.5086 25.0684
HeLa GDSC1; GDSC2; CTRP2 8.5392 23.0434 -0.4761 19.9564
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7790).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Effect of Aurora A kinase inhibitor MLN8237 combined with rituximab on antitumor activity in preclinical B-cell non-Hodgkin's lymphoma models. Journal of Clinical Oncology, 2009:8553.
4 Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter. Toxicol Appl Pharmacol. 2022 Jan 1;434:115823. doi: 10.1016/j.taap.2021.115823. Epub 2021 Dec 9.
5 Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma. Biochem Pharmacol. 2011 Apr 1;81(7):881-90. doi: 10.1016/j.bcp.2011.01.017. Epub 2011 Feb 1.
6 A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene. 2015 Jun;34(26):3357-68. doi: 10.1038/onc.2014.269. Epub 2014 Sep 1.